locus-tag	class	description
NIASO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NIASO_RS00015	COG3119	arylsulfatase activity
NIASO_RS00030	COG2204	response regulator
NIASO_RS00050	COG2204	response regulator
NIASO_RS00055	COG0339	signal peptide processing
NIASO_RS00065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NIASO_RS00070	COG2363	Small membrane protein
NIASO_RS00075	COG1674	ftsk spoiiie
NIASO_RS00085	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS00095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIASO_RS00105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NIASO_RS00115	COG0504	CTP synthase activity
NIASO_RS00120	COG0706	membrane insertase activity
NIASO_RS00125	COG1629	transport
NIASO_RS00130	COG4771	TonB-dependent receptor
NIASO_RS00145	COG0010	Belongs to the arginase family
NIASO_RS00155	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS00170	COG1193	negative regulation of DNA recombination
NIASO_RS00180	COG0387	Pfam Sodium calcium exchanger
NIASO_RS00185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NIASO_RS00190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIASO_RS00195	COG0045	succinate-CoA ligase (ADP-forming) activity
NIASO_RS00210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS00220	COG1609	Transcriptional regulator
NIASO_RS00235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIASO_RS00245	COG2226	methyltransferase
NIASO_RS00260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NIASO_RS00265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIASO_RS00270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIASO_RS00295	COG0793	Belongs to the peptidase S41A family
NIASO_RS00295	COG3409	Peptidoglycan-binding domain 1 protein
NIASO_RS00315	COG0268	Binds directly to 16S ribosomal RNA
NIASO_RS00330	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIASO_RS00335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIASO_RS00335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIASO_RS00360	COG0482	sulfurtransferase activity
NIASO_RS00365	COG0629	single-stranded DNA binding
NIASO_RS00375	COG0402	S-adenosylhomocysteine deaminase activity
NIASO_RS00380	COG0666	response to abiotic stimulus
NIASO_RS00385	COG0402	S-adenosylhomocysteine deaminase activity
NIASO_RS00395	COG0527	aspartate kinase activity
NIASO_RS00430	COG0617	tRNA 3'-terminal CCA addition
NIASO_RS00430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NIASO_RS00430	COG3620	sequence-specific DNA binding
NIASO_RS00435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIASO_RS00440	COG2211	Major facilitator Superfamily
NIASO_RS00450	COG1830	Aldolase
NIASO_RS00460	COG1609	Transcriptional regulator
NIASO_RS00475	COG1609	Transcriptional regulator
NIASO_RS00505	COG4206	TonB-dependent receptor
NIASO_RS00505	COG1629	transport
NIASO_RS00525	COG0523	cobalamin synthesis protein
NIASO_RS00545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIASO_RS00575	COG0543	2 iron, 2 sulfur cluster binding
NIASO_RS00575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIASO_RS00580	COG0673	inositol 2-dehydrogenase activity
NIASO_RS00600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIASO_RS00605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIASO_RS00610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIASO_RS00620	COG0473	3-isopropylmalate dehydrogenase activity
NIASO_RS00635	COG0066	3-isopropylmalate dehydratase activity
NIASO_RS00640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NIASO_RS00660	COG2885	chlorophyll binding
NIASO_RS00670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIASO_RS00695	COG0747	negative chemotaxis
NIASO_RS00750	COG2814	Major facilitator Superfamily
NIASO_RS00755	COG1538	Outer membrane efflux protein
NIASO_RS00775	COG0346	lactoylglutathione lyase activity
NIASO_RS00795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NIASO_RS00805	COG0247	lactate metabolic process
NIASO_RS00805	COG2181	nitrate reductase activity
NIASO_RS00810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NIASO_RS00820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NIASO_RS00825	COG0673	inositol 2-dehydrogenase activity
NIASO_RS00850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIASO_RS00860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIASO_RS00865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIASO_RS00885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIASO_RS00895	COG0740	serine-type endopeptidase activity
NIASO_RS00930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIASO_RS00975	COG2755	lipolytic protein G-D-S-L family
NIASO_RS00975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NIASO_RS01030	COG0564	pseudouridine synthase activity
NIASO_RS01035	COG0321	lipoyl(octanoyl) transferase activity
NIASO_RS01040	COG0077	Prephenate dehydratase
NIASO_RS01040	COG1605	Chorismate mutase
NIASO_RS01055	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NIASO_RS01060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIASO_RS01065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NIASO_RS01070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NIASO_RS01075	COG2261	transglycosylase associated protein
NIASO_RS01080	COG0788	formyltetrahydrofolate deformylase activity
NIASO_RS01085	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NIASO_RS01095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NIASO_RS01100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NIASO_RS01120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NIASO_RS01145	COG0488	(ABC) transporter
NIASO_RS01180	COG1525	nuclease
NIASO_RS01210	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
NIASO_RS01215	COG1943	Transposase
NIASO_RS01220	COG1518	maintenance of DNA repeat elements
NIASO_RS01225	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NIASO_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS01250	COG0484	heat shock protein binding
NIASO_RS01265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NIASO_RS01270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NIASO_RS01280	COG1166	arginine decarboxylase activity
NIASO_RS01290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIASO_RS01350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NIASO_RS01375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NIASO_RS01400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NIASO_RS01415	COG0825	malonyl-CoA metabolic process
NIASO_RS01420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIASO_RS01435	COG0018	arginyl-trna synthetase
NIASO_RS01450	COG0443	Heat shock 70 kDa protein
NIASO_RS01455	COG0363	glucosamine-6-phosphate deaminase activity
NIASO_RS01460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS01470	COG1446	asparaginase
NIASO_RS01475	COG3142	Participates in the control of copper homeostasis
NIASO_RS01500	COG0481	GTPase activity
NIASO_RS01520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NIASO_RS01535	COG0358	DNA primase activity
NIASO_RS01615	COG1012	belongs to the aldehyde dehydrogenase family
NIASO_RS01625	COG1725	Transcriptional regulator
NIASO_RS01635	COG1131	(ABC) transporter
NIASO_RS01640	COG2115	Belongs to the xylose isomerase family
NIASO_RS01645	COG1070	Carbohydrate kinase
NIASO_RS01655	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS01660	COG3250	beta-galactosidase activity
NIASO_RS01665	COG0702	epimerase
NIASO_RS01670	COG4771	TonB-dependent receptor
NIASO_RS01675	COG3661	Belongs to the glycosyl hydrolase 67 family
NIASO_RS01685	COG2211	Major facilitator Superfamily
NIASO_RS01710	COG1278	Cold shock
NIASO_RS01720	COG0724	RNA recognition motif
NIASO_RS01765	COG1609	Transcriptional regulator
NIASO_RS01780	COG1129	ABC transporter
NIASO_RS01785	COG1172	Belongs to the binding-protein-dependent transport system permease family
NIASO_RS01790	COG0246	Mannitol dehydrogenase
NIASO_RS01805	COG4771	TonB-dependent receptor
NIASO_RS01810	COG0702	epimerase
NIASO_RS01815	COG3940	Belongs to the glycosyl hydrolase 43 family
NIASO_RS01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIASO_RS01845	COG1131	(ABC) transporter
NIASO_RS01850	COG1131	(ABC) transporter
NIASO_RS01855	COG0842	Transport permease protein
NIASO_RS01875	COG4771	TonB-dependent receptor
NIASO_RS01880	COG0561	phosphatase activity
NIASO_RS01900	COG1966	Carbon starvation protein
NIASO_RS01905	COG1858	cytochrome C peroxidase
NIASO_RS01935	COG0668	transmembrane transport
NIASO_RS01950	COG0110	maltose O-acetyltransferase activity
NIASO_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS01965	COG2259	Doxx family
NIASO_RS01970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIASO_RS01975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NIASO_RS01985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIASO_RS01985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIASO_RS02020	COG1454	alcohol dehydrogenase
NIASO_RS02025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIASO_RS02030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIASO_RS02035	COG3395	kinase activity
NIASO_RS02040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIASO_RS02055	COG4413	Urea transporter
NIASO_RS02065	COG0829	nickel cation binding
NIASO_RS02070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIASO_RS02075	COG0830	nickel cation binding
NIASO_RS02080	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NIASO_RS02085	COG0804	urea catabolic process
NIASO_RS02090	COG0832	Belongs to the urease beta subunit family
NIASO_RS02095	COG0831	urea catabolic process
NIASO_RS02125	COG2885	chlorophyll binding
NIASO_RS02195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS02220	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NIASO_RS02225	COG3685	Protein conserved in bacteria
NIASO_RS02235	COG3852	Histidine kinase
NIASO_RS02240	COG0745	RESPONSE REGULATOR receiver
NIASO_RS02245	COG2204	response regulator
NIASO_RS02280	COG4651	solute:proton antiporter activity
NIASO_RS02280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIASO_RS02300	COG3250	beta-galactosidase activity
NIASO_RS02310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS02320	COG0477	Major facilitator Superfamily
NIASO_RS02325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NIASO_RS02330	COG1607	acyl-coa hydrolase
NIASO_RS02355	COG0583	DNA-binding transcription factor activity
NIASO_RS02365	COG0667	Aldo Keto reductase
NIASO_RS02370	COG0346	lactoylglutathione lyase activity
NIASO_RS02375	COG2032	superoxide dismutase activity
NIASO_RS02395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NIASO_RS02420	COG0604	alcohol dehydrogenase
NIASO_RS02420	COG3321	synthase
NIASO_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS02425	COG4941	Belongs to the sigma-70 factor family
NIASO_RS02435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIASO_RS02440	COG0673	inositol 2-dehydrogenase activity
NIASO_RS02455	COG0039	L-malate dehydrogenase activity
NIASO_RS02475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NIASO_RS02475	COG1199	ATP-dependent helicase activity
NIASO_RS02485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIASO_RS02490	COG0307	riboflavin synthase, alpha
NIASO_RS02495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NIASO_RS02500	COG4974	Belongs to the 'phage' integrase family
NIASO_RS02530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIASO_RS02535	COG1160	GTP binding
NIASO_RS02590	COG3345	alpha-galactosidase
NIASO_RS02620	COG2198	Histidine kinase
NIASO_RS02620	COG0643	Histidine kinase
NIASO_RS02620	COG0784	Response regulator, receiver
NIASO_RS02635	COG4948	Mandelate Racemase Muconate Lactonizing
NIASO_RS02640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIASO_RS02650	COG1862	Preprotein translocase
NIASO_RS02660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIASO_RS02665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIASO_RS02670	COG0459	protein refolding
NIASO_RS02680	COG0488	(ABC) transporter
NIASO_RS02700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NIASO_RS02705	COG0484	heat shock protein binding
NIASO_RS02725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NIASO_RS02730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NIASO_RS02740	COG0247	lactate metabolic process
NIASO_RS02740	COG2181	nitrate reductase activity
NIASO_RS02750	COG0456	acetyltransferase
NIASO_RS02755	COG1940	carbohydrate kinase activity
NIASO_RS02760	COG1629	transport
NIASO_RS02785	COG1183	phosphatidylcholine synthase activity
NIASO_RS02795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIASO_RS02800	COG0612	Peptidase, M16
NIASO_RS02805	COG3250	beta-galactosidase activity
NIASO_RS02820	COG0745	RESPONSE REGULATOR receiver
NIASO_RS02820	COG2205	protein histidine kinase activity
NIASO_RS02820	COG3292	Two component regulator propeller
NIASO_RS02825	COG1629	transport
NIASO_RS02840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS02850	COG0038	chloride channel
NIASO_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIASO_RS02875	COG0191	fructose-bisphosphate aldolase activity
NIASO_RS02895	COG0069	glutamate synthase activity
NIASO_RS02900	COG2003	Belongs to the UPF0758 family
NIASO_RS02905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIASO_RS02910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NIASO_RS02915	COG0193	aminoacyl-tRNA hydrolase activity
NIASO_RS02920	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIASO_RS02945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIASO_RS02955	COG0673	inositol 2-dehydrogenase activity
NIASO_RS02970	COG0693	protein deglycase activity
NIASO_RS02975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIASO_RS02990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIASO_RS03015	COG1012	belongs to the aldehyde dehydrogenase family
NIASO_RS03070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIASO_RS03095	COG1473	amidohydrolase
NIASO_RS03115	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIASO_RS03120	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS03125	COG1914	H( )-stimulated, divalent metal cation uptake system
NIASO_RS03170	COG1349	DNA-binding transcription factor activity
NIASO_RS03175	COG1595	DNA-templated transcription, initiation
NIASO_RS03185	COG1629	transport
NIASO_RS03190	COG0561	phosphatase activity
NIASO_RS03210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIASO_RS03255	COG4771	TonB-dependent receptor
NIASO_RS03260	COG0702	epimerase
NIASO_RS03310	COG1473	amidohydrolase
NIASO_RS03325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NIASO_RS03325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NIASO_RS03330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NIASO_RS03330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NIASO_RS03335	COG0859	PFAM glycosyl transferase family 9
NIASO_RS03345	COG0277	FAD linked oxidase domain protein
NIASO_RS03350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIASO_RS03355	COG2346	COG2346, Truncated hemoglobins
NIASO_RS03380	COG0302	gtp cyclohydrolase
NIASO_RS03395	COG2910	NAD(P)H-binding
NIASO_RS03405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NIASO_RS03420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIASO_RS03430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NIASO_RS03435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIASO_RS03435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NIASO_RS03500	COG1595	DNA-templated transcription, initiation
NIASO_RS03510	COG1629	transport
NIASO_RS03515	COG0702	epimerase
NIASO_RS03535	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIASO_RS03545	COG0497	DNA recombination
NIASO_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NIASO_RS03575	COG1132	(ABC) transporter
NIASO_RS03605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NIASO_RS03610	COG2086	electron transfer activity
NIASO_RS03620	COG0037	tRNA processing
NIASO_RS03625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NIASO_RS03630	COG1295	ribonuclease BN
NIASO_RS03670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIASO_RS03700	COG0540	Belongs to the ATCase OTCase family
NIASO_RS03705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NIASO_RS03715	COG1254	Belongs to the acylphosphatase family
NIASO_RS03720	COG1956	GAF domain-containing protein
NIASO_RS03730	COG0405	Gamma-glutamyltransferase
NIASO_RS03770	COG4771	TonB-dependent receptor
NIASO_RS03780	COG3940	Belongs to the glycosyl hydrolase 43 family
NIASO_RS03785	COG3408	Glycogen debranching enzyme
NIASO_RS03785	COG3119	arylsulfatase activity
NIASO_RS03790	COG0477	Major facilitator Superfamily
NIASO_RS03790	COG2814	Major facilitator Superfamily
NIASO_RS03805	COG0745	RESPONSE REGULATOR receiver
NIASO_RS03815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS03825	COG2755	lipolytic protein G-D-S-L family
NIASO_RS03825	COG0657	acetylesterase activity
NIASO_RS03835	COG2271	Major facilitator Superfamily
NIASO_RS03850	COG4771	TonB-dependent receptor
NIASO_RS03855	COG2186	Transcriptional regulator
NIASO_RS03865	COG2186	Transcriptional regulator
NIASO_RS03870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIASO_RS03880	COG2755	lipolytic protein G-D-S-L family
NIASO_RS03885	COG2988	succinylglutamate desuccinylase activity
NIASO_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS03895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIASO_RS03900	COG0251	oxidation-reduction process
NIASO_RS03910	COG3386	PFAM SMP-30 Gluconolaconase
NIASO_RS03930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIASO_RS03935	COG2814	Major facilitator Superfamily
NIASO_RS03945	COG2827	Endonuclease containing a URI domain
NIASO_RS03965	COG0531	amino acid
NIASO_RS03970	COG1301	dicarboxylic acid transport
NIASO_RS03975	COG0586	Pfam SNARE associated Golgi protein
NIASO_RS03985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NIASO_RS04005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NIASO_RS04015	COG1047	Peptidyl-prolyl cis-trans
NIASO_RS04020	COG2195	Cleaves the N-terminal amino acid of tripeptides
NIASO_RS04030	COG2890	protein-(glutamine-N5) methyltransferase activity
NIASO_RS04035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIASO_RS04035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIASO_RS04040	COG1739	Uncharacterized protein family UPF0029
NIASO_RS04090	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
NIASO_RS04150	COG0022	dehydrogenase e1 component
NIASO_RS04150	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIASO_RS04160	COG0492	ferredoxin-NADP+ reductase activity
NIASO_RS04165	COG0183	Belongs to the thiolase family
NIASO_RS04180	COG3876	Protein conserved in bacteria
NIASO_RS04195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NIASO_RS04200	COG1663	tetraacyldisaccharide 4'-kinase activity
NIASO_RS04205	COG0557	exoribonuclease II activity
NIASO_RS04220	COG0531	amino acid
NIASO_RS04225	COG1193	negative regulation of DNA recombination
NIASO_RS04270	COG1054	Belongs to the UPF0176 family
NIASO_RS04275	COG0105	UTP biosynthetic process
NIASO_RS04285	COG0545	Peptidyl-prolyl cis-trans isomerase
NIASO_RS04295	COG3118	belongs to the thioredoxin family
NIASO_RS04300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIASO_RS04315	COG0601	transmembrane transport
NIASO_RS04330	COG0739	heme binding
NIASO_RS04335	COG3657	addiction module killer protein
NIASO_RS04350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIASO_RS04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIASO_RS04365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NIASO_RS04370	COG0247	lactate metabolic process
NIASO_RS04375	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
NIASO_RS04380	COG0546	phosphoglycolate phosphatase activity
NIASO_RS04405	COG3186	Phenylalanine-4-hydroxylase
NIASO_RS04420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS04430	COG3511	phospholipase C
NIASO_RS04440	COG0196	riboflavin kinase activity
NIASO_RS04445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NIASO_RS04515	COG3119	arylsulfatase activity
NIASO_RS04545	COG3119	arylsulfatase activity
NIASO_RS04550	COG0577	efflux transmembrane transporter activity
NIASO_RS04560	COG1678	Uncharacterized ACR, COG1678
NIASO_RS04565	COG3250	beta-galactosidase activity
NIASO_RS04575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS04595	COG4948	Mandelate Racemase Muconate Lactonizing
NIASO_RS04615	COG0702	epimerase
NIASO_RS04620	COG1629	transport
NIASO_RS04715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NIASO_RS04720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIASO_RS04740	COG0513	Belongs to the DEAD box helicase family
NIASO_RS04760	COG2205	protein histidine kinase activity
NIASO_RS04760	COG2205	protein histidine kinase activity
NIASO_RS04760	COG0745	RESPONSE REGULATOR receiver
NIASO_RS04760	COG3292	Two component regulator propeller
NIASO_RS04760	COG0745	RESPONSE REGULATOR receiver
NIASO_RS04760	COG3292	Two component regulator propeller
NIASO_RS04795	COG0587	DNA-directed DNA polymerase activity
NIASO_RS04840	COG1045	serine acetyltransferase
NIASO_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS04865	COG0772	Belongs to the SEDS family
NIASO_RS04875	COG0631	protein serine/threonine phosphatase activity
NIASO_RS04895	COG0205	6-phosphofructokinase activity
NIASO_RS04910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIASO_RS04915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIASO_RS04940	COG1442	glycosyl transferase family 8
NIASO_RS04940	COG1216	Glycosyl transferase, family 2
NIASO_RS04945	COG1216	Glycosyl transferase, family 2
NIASO_RS04965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NIASO_RS04970	COG0505	Belongs to the CarA family
NIASO_RS04980	COG2318	DinB family
NIASO_RS04985	COG0545	Peptidyl-prolyl cis-trans isomerase
NIASO_RS05000	COG1131	(ABC) transporter
NIASO_RS05005	COG0527	aspartate kinase activity
NIASO_RS05020	COG0166	Belongs to the GPI family
NIASO_RS05030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NIASO_RS05040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIASO_RS05070	COG3119	arylsulfatase activity
NIASO_RS05085	COG0295	cytidine deaminase activity
NIASO_RS05110	COG0492	ferredoxin-NADP+ reductase activity
NIASO_RS05120	COG2183	response to ionizing radiation
NIASO_RS05135	COG2217	Heavy metal translocating P-type atpase
NIASO_RS05140	COG0670	Belongs to the BI1 family
NIASO_RS05155	COG4654	Cytochrome c, class I
NIASO_RS05165	COG2211	Major facilitator Superfamily
NIASO_RS05180	COG0793	Belongs to the peptidase S41A family
NIASO_RS05230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIASO_RS05250	COG0424	maF-like protein
NIASO_RS05285	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NIASO_RS05300	COG0519	Catalyzes the synthesis of GMP from XMP
NIASO_RS05340	COG0305	Participates in initiation and elongation during chromosome replication
NIASO_RS05340	COG0358	DNA primase activity
NIASO_RS05415	COG0653	protein targeting
NIASO_RS05465	COG0513	Belongs to the DEAD box helicase family
NIASO_RS05500	COG0724	RNA recognition motif
NIASO_RS05525	COG5002	protein histidine kinase activity
NIASO_RS05530	COG0745	RESPONSE REGULATOR receiver
NIASO_RS05540	COG0667	Aldo Keto reductase
NIASO_RS05555	COG1073	alpha beta
NIASO_RS05590	COG3250	beta-galactosidase activity
NIASO_RS05590	COG5297	Belongs to the glycosyl hydrolase family 6
NIASO_RS05595	COG4221	oxidoreductase activity
NIASO_RS05610	COG2239	Acts as a magnesium transporter
NIASO_RS05615	COG1349	DNA-binding transcription factor activity
NIASO_RS05620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NIASO_RS05625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIASO_RS05650	COG0488	(ABC) transporter
NIASO_RS05665	COG0149	triose-phosphate isomerase activity
NIASO_RS05670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIASO_RS05675	COG0254	rRNA binding
NIASO_RS05680	COG1666	GTP binding
NIASO_RS05685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIASO_RS05690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIASO_RS05695	COG0248	Ppx GppA phosphatase
NIASO_RS05700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NIASO_RS05715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIASO_RS05720	COG1741	Belongs to the pirin family
NIASO_RS05735	COG0657	acetylesterase activity
NIASO_RS05735	COG2755	lipolytic protein G-D-S-L family
NIASO_RS05745	COG0463	Glycosyl transferase, family 2
NIASO_RS05750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NIASO_RS05755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIASO_RS05760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIASO_RS05765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIASO_RS05770	COG0131	Imidazoleglycerol-phosphate dehydratase
NIASO_RS05775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIASO_RS05785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NIASO_RS05795	COG0107	imidazoleglycerol-phosphate synthase activity
NIASO_RS05800	COG0140	phosphoribosyl-ATP diphosphatase activity
NIASO_RS05800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIASO_RS05845	COG0545	Peptidyl-prolyl cis-trans isomerase
NIASO_RS05855	COG1522	sequence-specific DNA binding
NIASO_RS05860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIASO_RS05900	COG3682	Transcriptional regulator
NIASO_RS05910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIASO_RS05930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIASO_RS05935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS05940	COG1477	protein flavinylation
NIASO_RS05955	COG3940	Belongs to the glycosyl hydrolase 43 family
NIASO_RS05980	COG0745	RESPONSE REGULATOR receiver
NIASO_RS05980	COG2205	protein histidine kinase activity
NIASO_RS05980	COG3292	Two component regulator propeller
NIASO_RS05985	COG2081	HI0933 family
NIASO_RS05990	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NIASO_RS06000	COG2169	Transcriptional regulator
NIASO_RS06005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIASO_RS06010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIASO_RS06015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NIASO_RS06025	COG0071	Belongs to the small heat shock protein (HSP20) family
NIASO_RS06050	COG1216	Glycosyl transferase, family 2
NIASO_RS06060	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS06070	COG0438	transferase activity, transferring glycosyl groups
NIASO_RS06075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIASO_RS06205	COG1595	DNA-templated transcription, initiation
NIASO_RS06215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIASO_RS06220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NIASO_RS06230	COG0297	glycogen (starch) synthase activity
NIASO_RS06235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NIASO_RS06240	COG1765	OsmC-like protein
NIASO_RS06250	COG1466	dna polymerase III delta subunit
NIASO_RS06260	COG4772	TonB-dependent receptor
NIASO_RS06265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NIASO_RS06275	COG2706	6-phosphogluconolactonase activity
NIASO_RS06295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIASO_RS06330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NIASO_RS06345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIASO_RS06355	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIASO_RS06360	COG0436	Aminotransferase
NIASO_RS06365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NIASO_RS06370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NIASO_RS06375	COG1505	serine-type exopeptidase activity
NIASO_RS06415	COG1629	transport
NIASO_RS06425	COG0436	Aminotransferase
NIASO_RS06430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIASO_RS06450	COG1914	H( )-stimulated, divalent metal cation uptake system
NIASO_RS06460	COG3258	Cytochrome c
NIASO_RS06475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NIASO_RS06525	COG3011	Protein conserved in bacteria
NIASO_RS06545	COG2259	Doxx family
NIASO_RS06575	COG1640	4-alpha-glucanotransferase
NIASO_RS06585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NIASO_RS06595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NIASO_RS06615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIASO_RS06620	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NIASO_RS06625	COG0719	Fe-S assembly protein
NIASO_RS06635	COG0396	ATPase activity
NIASO_RS06640	COG0719	Fe-S assembly protein
NIASO_RS06645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIASO_RS06650	COG2166	iron-sulfur cluster assembly
NIASO_RS06655	COG2151	metal-sulfur cluster biosynthetic enzyme
NIASO_RS06675	COG2197	response regulator
NIASO_RS06695	COG2166	iron-sulfur cluster assembly
NIASO_RS06700	COG2226	methyltransferase
NIASO_RS06705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIASO_RS06710	COG3119	arylsulfatase activity
NIASO_RS06730	COG0714	Associated with various cellular activities
NIASO_RS06735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIASO_RS06735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIASO_RS06765	COG0473	3-isopropylmalate dehydrogenase activity
NIASO_RS06780	COG2160	L-arabinose isomerase activity
NIASO_RS06790	COG1069	ribulokinase activity
NIASO_RS06795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIASO_RS06805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIASO_RS06830	COG1136	(ABC) transporter
NIASO_RS06830	COG0577	efflux transmembrane transporter activity
NIASO_RS06840	COG0577	efflux transmembrane transporter activity
NIASO_RS06865	COG0577	efflux transmembrane transporter activity
NIASO_RS06875	COG0577	efflux transmembrane transporter activity
NIASO_RS06880	COG0577	efflux transmembrane transporter activity
NIASO_RS06880	COG1136	(ABC) transporter
NIASO_RS06900	COG0577	efflux transmembrane transporter activity
NIASO_RS06910	COG1136	(ABC) transporter
NIASO_RS06950	COG0392	lysyltransferase activity
NIASO_RS06950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NIASO_RS06965	COG0784	Response regulator, receiver
NIASO_RS06965	COG2205	protein histidine kinase activity
NIASO_RS06975	COG3279	Response regulator of the LytR AlgR family
NIASO_RS07025	COG0343	queuine tRNA-ribosyltransferase activity
NIASO_RS07060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIASO_RS07065	COG0697	spore germination
NIASO_RS07070	COG1522	sequence-specific DNA binding
NIASO_RS07080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIASO_RS07085	COG0316	Belongs to the HesB IscA family
NIASO_RS07095	COG1138	Cytochrome C-type biogenesis protein
NIASO_RS07100	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIASO_RS07110	COG3264	Mechanosensitive ion channel
NIASO_RS07110	COG1196	nuclear chromosome segregation
NIASO_RS07135	COG3179	chitinase
NIASO_RS07150	COG1607	acyl-coa hydrolase
NIASO_RS07155	COG4232	protein-disulfide reductase activity
NIASO_RS07160	COG1091	dTDP-4-dehydrorhamnose reductase activity
NIASO_RS07175	COG1519	Transferase
NIASO_RS07185	COG1435	thymidine kinase activity
NIASO_RS07205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIASO_RS07220	COG0416	fatty acid biosynthetic process
NIASO_RS07225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NIASO_RS07240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIASO_RS07245	COG0460	homoserine dehydrogenase
NIASO_RS07250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NIASO_RS07255	COG0577	efflux transmembrane transporter activity
NIASO_RS07285	COG0129	dihydroxy-acid dehydratase activity
NIASO_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS07295	COG3386	PFAM SMP-30 Gluconolaconase
NIASO_RS07320	COG3258	Cytochrome c
NIASO_RS07325	COG2326	polyphosphate kinase activity
NIASO_RS07335	COG2235	arginine
NIASO_RS07345	COG3254	rhamnose metabolic process
NIASO_RS07360	COG4771	TonB-dependent receptor
NIASO_RS07365	COG0702	epimerase
NIASO_RS07415	COG3250	beta-galactosidase activity
NIASO_RS07430	COG3250	beta-galactosidase activity
NIASO_RS07435	COG3401	FG-GAP repeat protein
NIASO_RS07445	COG4771	TonB-dependent receptor
NIASO_RS07460	COG0702	epimerase
NIASO_RS07465	COG4771	TonB-dependent receptor
NIASO_RS07480	COG4206	TonB-dependent receptor
NIASO_RS07480	COG1629	transport
NIASO_RS07500	COG2755	lipolytic protein G-D-S-L family
NIASO_RS07510	COG3250	beta-galactosidase activity
NIASO_RS07580	COG3501	Rhs element vgr protein
NIASO_RS07635	COG0629	single-stranded DNA binding
NIASO_RS07670	COG4206	TonB-dependent receptor
NIASO_RS07680	COG2095	MarC family integral membrane protein
NIASO_RS07690	COG1418	mRNA catabolic process
NIASO_RS07695	COG2814	Major facilitator Superfamily
NIASO_RS07700	COG0335	large ribosomal subunit rRNA binding
NIASO_RS07705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIASO_RS07710	COG0154	amidase activity
NIASO_RS07715	COG1388	LysM domain
NIASO_RS07715	COG0741	lytic transglycosylase activity
NIASO_RS07745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIASO_RS07750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIASO_RS07760	COG0544	peptidyl-prolyl cis-trans isomerase activity
NIASO_RS07775	COG0024	Methionine aminopeptidase
NIASO_RS07785	COG0200	Binds to the 23S rRNA
NIASO_RS07790	COG1841	ribosomal large subunit assembly
NIASO_RS07795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NIASO_RS07800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NIASO_RS07805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NIASO_RS07810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NIASO_RS07815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NIASO_RS07820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIASO_RS07825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NIASO_RS07830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NIASO_RS07835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NIASO_RS07840	COG0255	Belongs to the universal ribosomal protein uL29 family
NIASO_RS07845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NIASO_RS07850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NIASO_RS07860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NIASO_RS07865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIASO_RS07870	COG0089	rRNA binding
NIASO_RS07875	COG0088	Forms part of the polypeptide exit tunnel
NIASO_RS07880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NIASO_RS07885	COG0051	transcription antitermination factor activity, RNA binding
NIASO_RS07905	COG0242	peptide deformylase activity
NIASO_RS07915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NIASO_RS07920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIASO_RS07925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIASO_RS07940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIASO_RS07945	COG0110	maltose O-acetyltransferase activity
NIASO_RS07950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIASO_RS07955	COG3239	Fatty acid desaturase
NIASO_RS07965	COG0632	four-way junction helicase activity
NIASO_RS07970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIASO_RS08000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIASO_RS08005	COG0515	serine threonine protein kinase
NIASO_RS08005	COG2815	serine threonine protein kinase
NIASO_RS08010	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIASO_RS08015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIASO_RS08040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NIASO_RS08050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIASO_RS08075	COG0366	Alpha amylase catalytic
NIASO_RS08085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIASO_RS08090	COG0297	glycogen (starch) synthase activity
NIASO_RS08100	COG1940	carbohydrate kinase activity
NIASO_RS08120	COG0525	valine-tRNA ligase activity
NIASO_RS08150	COG1185	polyribonucleotide nucleotidyltransferase activity
NIASO_RS08155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NIASO_RS08180	COG3220	belongs to the UPF0276 family
NIASO_RS08205	COG3345	alpha-galactosidase
NIASO_RS08210	COG1960	acyl-CoA dehydrogenase activity
NIASO_RS08215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS08215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS08225	COG0552	protein localization to endoplasmic reticulum
NIASO_RS08230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NIASO_RS08235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NIASO_RS08240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIASO_RS08250	COG1301	dicarboxylic acid transport
NIASO_RS08265	COG0745	RESPONSE REGULATOR receiver
NIASO_RS08270	COG5002	protein histidine kinase activity
NIASO_RS08285	COG0596	Alpha beta hydrolase
NIASO_RS08300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIASO_RS08310	COG0463	Glycosyl transferase, family 2
NIASO_RS08335	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NIASO_RS08355	COG3590	peptidase
NIASO_RS08360	COG1528	Iron-storage protein
NIASO_RS08375	COG3209	COG3209 Rhs family protein
NIASO_RS08375	COG4104	PAAR repeat-containing protein
NIASO_RS08390	COG3209	COG3209 Rhs family protein
NIASO_RS08450	COG4221	oxidoreductase activity
NIASO_RS08550	COG3278	Belongs to the heme-copper respiratory oxidase family
NIASO_RS08570	COG2205	protein histidine kinase activity
NIASO_RS08605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NIASO_RS08605	COG2755	lipolytic protein G-D-S-L family
NIASO_RS08620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NIASO_RS08625	COG2153	protein acetylation
NIASO_RS08655	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
NIASO_RS08665	COG0705	Rhomboid family
NIASO_RS08695	COG0049	tRNA binding
NIASO_RS08700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NIASO_RS08715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NIASO_RS08720	COG1595	DNA-templated transcription, initiation
NIASO_RS08745	COG1012	belongs to the aldehyde dehydrogenase family
NIASO_RS08755	COG1271	oxidase subunit
NIASO_RS08770	COG2814	Major facilitator Superfamily
NIASO_RS08785	COG1309	transcriptional regulator
NIASO_RS08790	COG1228	amidohydrolase
NIASO_RS08800	COG0004	ammonium transporteR
NIASO_RS08815	COG0436	Aminotransferase
NIASO_RS08840	COG0284	orotidine-5'-phosphate decarboxylase activity
NIASO_RS08850	COG0792	nuclease activity
NIASO_RS08860	COG4974	Belongs to the 'phage' integrase family
NIASO_RS08890	COG0612	Peptidase, M16
NIASO_RS08915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NIASO_RS08920	COG2264	protein methyltransferase activity
NIASO_RS08925	COG2733	membrane
NIASO_RS08930	COG0534	Mate efflux family protein
NIASO_RS08950	COG0010	Belongs to the arginase family
NIASO_RS08955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NIASO_RS08960	COG1228	amidohydrolase
NIASO_RS08965	COG2986	histidine ammonia-lyase
NIASO_RS08970	COG0583	DNA-binding transcription factor activity
NIASO_RS08995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIASO_RS09000	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NIASO_RS09035	COG0305	Participates in initiation and elongation during chromosome replication
NIASO_RS09040	COG0357	Ribosomal RNA small subunit methyltransferase G
NIASO_RS09070	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
NIASO_RS09090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIASO_RS09095	COG1418	mRNA catabolic process
NIASO_RS09100	COG0436	Aminotransferase
NIASO_RS09135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NIASO_RS09150	COG4145	pantothenate transmembrane transporter activity
NIASO_RS09155	COG1611	Belongs to the LOG family
NIASO_RS09160	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NIASO_RS09165	COG3279	Response regulator of the LytR AlgR family
NIASO_RS09170	COG3275	phosphorelay sensor kinase activity
NIASO_RS09200	COG3189	MarR family transcriptional regulator
NIASO_RS09205	COG1196	nuclear chromosome segregation
NIASO_RS09220	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NIASO_RS09235	COG0640	Transcriptional regulator
NIASO_RS09245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIASO_RS09265	COG0659	secondary active sulfate transmembrane transporter activity
NIASO_RS09270	COG0288	reversible hydration of carbon dioxide
NIASO_RS09280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NIASO_RS09285	COG1024	Enoyl-CoA hydratase
NIASO_RS09295	COG1960	acyl-CoA dehydrogenase activity
NIASO_RS09315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NIASO_RS09365	COG0588	phosphoglycerate mutase activity
NIASO_RS09370	COG1070	Carbohydrate kinase
NIASO_RS09375	COG1070	Carbohydrate kinase
NIASO_RS09380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIASO_RS09385	COG2814	Major facilitator Superfamily
NIASO_RS09390	COG1349	DNA-binding transcription factor activity
NIASO_RS09405	COG0445	tRNA wobble uridine modification
NIASO_RS09410	COG2271	Major facilitator Superfamily
NIASO_RS09425	COG4771	TonB-dependent receptor
NIASO_RS09460	COG0101	tRNA pseudouridine synthase activity
NIASO_RS09490	COG1704	LemA family
NIASO_RS09500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NIASO_RS09510	COG0126	phosphoglycerate kinase activity
NIASO_RS09555	COG2194	sulfuric ester hydrolase activity
NIASO_RS09565	COG2205	protein histidine kinase activity
NIASO_RS09575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NIASO_RS09585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIASO_RS09590	COG2204	response regulator
NIASO_RS09605	COG2353	YceI-like domain
NIASO_RS09610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIASO_RS09630	COG4774	siderophore transport
NIASO_RS09650	COG2267	carboxylic ester hydrolase activity
NIASO_RS09700	COG2169	Transcriptional regulator
NIASO_RS09715	COG0673	inositol 2-dehydrogenase activity
NIASO_RS09720	COG3250	beta-galactosidase activity
NIASO_RS09725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NIASO_RS09745	COG0019	diaminopimelate decarboxylase activity
NIASO_RS09755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NIASO_RS09790	COG1629	transport
NIASO_RS09810	COG1629	transport
NIASO_RS09810	COG4206	TonB-dependent receptor
NIASO_RS09820	COG4206	TonB-dependent receptor
NIASO_RS09820	COG1629	transport
NIASO_RS09825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NIASO_RS09830	COG0602	queuosine metabolic process
NIASO_RS09835	COG1363	Peptidase, m42
NIASO_RS09845	COG4771	TonB-dependent receptor
NIASO_RS09850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIASO_RS09870	COG1678	Uncharacterized ACR, COG1678
NIASO_RS09880	COG1714	RDD family
NIASO_RS09885	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NIASO_RS09890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NIASO_RS09910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NIASO_RS09990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS10005	COG1501	Belongs to the glycosyl hydrolase 31 family
NIASO_RS10020	COG3250	beta-galactosidase activity
NIASO_RS10030	COG0702	epimerase
NIASO_RS10035	COG4771	TonB-dependent receptor
NIASO_RS10055	COG0662	Cupin 2, conserved barrel domain protein
NIASO_RS10055	COG2207	Transcriptional regulator
NIASO_RS10080	COG4771	TonB-dependent receptor
NIASO_RS10105	COG4771	TonB-dependent receptor
NIASO_RS10115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIASO_RS10130	COG1136	(ABC) transporter
NIASO_RS10140	COG2096	Adenosyltransferase
NIASO_RS10145	COG1136	(ABC) transporter
NIASO_RS10150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIASO_RS10160	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NIASO_RS10165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIASO_RS10175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIASO_RS10205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NIASO_RS10210	COG0667	Aldo Keto reductase
NIASO_RS10245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NIASO_RS10260	COG0531	amino acid
NIASO_RS10275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NIASO_RS10310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIASO_RS10315	COG0085	RNA polymerase activity
NIASO_RS10325	COG4942	peptidase
NIASO_RS10345	COG0222	ribosome binding
NIASO_RS10350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NIASO_RS10355	COG0081	regulation of translation
NIASO_RS10360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NIASO_RS10365	COG1132	(ABC) transporter
NIASO_RS10395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NIASO_RS10400	COG1809	phosphosulfolactate synthase activity
NIASO_RS10405	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NIASO_RS10410	COG0156	8-amino-7-oxononanoate synthase activity
NIASO_RS10425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NIASO_RS10450	COG0047	phosphoribosylformylglycinamidine synthase activity
NIASO_RS10465	COG3158	transport of potassium into the cell
NIASO_RS10510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIASO_RS10520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NIASO_RS10530	COG0662	Cupin 2, conserved barrel domain protein
NIASO_RS10550	COG1595	DNA-templated transcription, initiation
NIASO_RS10560	COG4771	TonB-dependent receptor
NIASO_RS10570	COG0673	inositol 2-dehydrogenase activity
NIASO_RS10595	COG1335	isochorismatase
NIASO_RS10600	COG0148	phosphopyruvate hydratase activity
NIASO_RS10625	COG1024	Enoyl-CoA hydratase
NIASO_RS10625	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIASO_RS10660	COG0811	peptide transport
NIASO_RS10665	COG0577	efflux transmembrane transporter activity
NIASO_RS10670	COG1007	ATP synthesis coupled electron transport
NIASO_RS10675	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIASO_RS10680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIASO_RS10690	COG0839	Belongs to the complex I subunit 6 family
NIASO_RS10695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIASO_RS10700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIASO_RS10705	COG1034	ATP synthesis coupled electron transport
NIASO_RS10720	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NIASO_RS10730	COG0649	NAD binding
NIASO_RS10735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIASO_RS10740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIASO_RS10745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIASO_RS10770	COG0084	hydrolase, TatD family'
NIASO_RS10780	COG2827	Endonuclease containing a URI domain
NIASO_RS10815	COG0542	response to heat
NIASO_RS10825	COG0791	NLP P60 protein
NIASO_RS10880	COG1490	D-aminoacyl-tRNA deacylase activity
NIASO_RS10885	COG1694	Mazg nucleotide pyrophosphohydrolase
NIASO_RS10890	COG1295	ribonuclease BN
NIASO_RS10895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS10905	COG0277	FAD linked oxidase domain protein
NIASO_RS10910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIASO_RS10935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIASO_RS10935	COG0519	Catalyzes the synthesis of GMP from XMP
NIASO_RS10945	COG0180	Tryptophanyl-tRNA synthetase
NIASO_RS10950	COG1428	Deoxynucleoside kinase
NIASO_RS10965	COG4771	TonB-dependent receptor
NIASO_RS10980	COG0006	proline dipeptidase activity
NIASO_RS10990	COG1053	succinate dehydrogenase
NIASO_RS11030	COG0346	lactoylglutathione lyase activity
NIASO_RS11045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIASO_RS11050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NIASO_RS11055	COG0756	dUTP diphosphatase activity
NIASO_RS11070	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIASO_RS11100	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIASO_RS11105	COG4290	ribonuclease
NIASO_RS11110	COG2732	(Barnase) inhibitor
NIASO_RS11120	COG0489	protein tyrosine kinase activity
NIASO_RS11130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NIASO_RS11140	COG1475	DNA binding
NIASO_RS11145	COG1192	Involved in chromosome partitioning
NIASO_RS11150	COG1408	metallophosphoesterase
NIASO_RS11160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NIASO_RS11175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIASO_RS11185	COG1702	phosphate starvation-inducible protein PhoH
NIASO_RS11205	COG0791	NLP P60 protein
NIASO_RS11225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIASO_RS11235	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NIASO_RS11245	COG4152	abc transporter atp-binding protein
NIASO_RS11295	COG1595	DNA-templated transcription, initiation
NIASO_RS11300	COG0772	Belongs to the SEDS family
NIASO_RS11320	COG1077	Cell shape determining protein MreB Mrl
NIASO_RS11325	COG3958	Transketolase
NIASO_RS11350	COG4993	Dehydrogenase
NIASO_RS11365	COG3408	Glycogen debranching enzyme
NIASO_RS11370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NIASO_RS11375	COG0203	ribosomal protein L17
NIASO_RS11380	COG0202	RNA polymerase activity
NIASO_RS11385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIASO_RS11390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NIASO_RS11395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NIASO_RS11400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NIASO_RS11440	COG0702	epimerase
NIASO_RS11445	COG1629	transport
NIASO_RS11465	COG1703	isobutyryl-CoA mutase activity
NIASO_RS11465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS11465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS11470	COG4804	nuclease activity
NIASO_RS11475	COG1703	isobutyryl-CoA mutase activity
NIASO_RS11475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS11475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS11480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIASO_RS11485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NIASO_RS11495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIASO_RS11500	COG1595	DNA-templated transcription, initiation
NIASO_RS11505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIASO_RS11555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS11560	COG0450	alkyl hydroperoxide reductase
NIASO_RS11565	COG0688	phosphatidylethanolamine metabolic process
NIASO_RS11590	COG0667	Aldo Keto reductase
NIASO_RS11615	COG1660	Displays ATPase and GTPase activities
NIASO_RS11620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NIASO_RS11630	COG1162	GTPase activity
NIASO_RS11635	COG2171	N-acyltransferase activity
NIASO_RS11645	COG0009	L-threonylcarbamoyladenylate synthase
NIASO_RS11650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NIASO_RS11650	COG0617	tRNA 3'-terminal CCA addition
NIASO_RS11650	COG0517	IMP dehydrogenase activity
NIASO_RS11675	COG0673	inositol 2-dehydrogenase activity
NIASO_RS11680	COG1609	Transcriptional regulator
NIASO_RS11680	COG2207	Transcriptional regulator
NIASO_RS11700	COG0667	Aldo Keto reductase
NIASO_RS11705	COG0528	UMP kinase activity
NIASO_RS11735	COG0708	Exodeoxyribonuclease III
NIASO_RS11740	COG1611	Belongs to the LOG family
NIASO_RS11765	COG4804	nuclease activity
NIASO_RS11775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NIASO_RS11805	COG1629	transport
NIASO_RS11845	COG1741	Belongs to the pirin family
NIASO_RS11850	COG2076	Multidrug Resistance protein
NIASO_RS11860	COG3279	Response regulator of the LytR AlgR family
NIASO_RS11865	COG3275	phosphorelay sensor kinase activity
NIASO_RS11875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NIASO_RS11905	COG0336	Belongs to the RNA methyltransferase TrmD family
NIASO_RS11910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NIASO_RS11915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NIASO_RS11935	COG5002	protein histidine kinase activity
NIASO_RS11940	COG0745	RESPONSE REGULATOR receiver
NIASO_RS11965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NIASO_RS12005	COG1266	CAAX protease self-immunity
NIASO_RS12020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIASO_RS12035	COG3655	Transcriptional regulator
NIASO_RS12040	COG0151	Belongs to the GarS family
NIASO_RS12045	COG3104	oligopeptide transport
NIASO_RS12050	COG1297	OPT oligopeptide transporter protein
NIASO_RS12065	COG3622	Belongs to the hyi family
NIASO_RS12070	COG0515	serine threonine protein kinase
NIASO_RS12070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIASO_RS12075	COG0673	inositol 2-dehydrogenase activity
NIASO_RS12080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NIASO_RS12100	COG0210	DNA helicase
NIASO_RS12125	COG2814	Major facilitator Superfamily
NIASO_RS12135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIASO_RS12150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS12170	COG4771	TonB-dependent receptor
NIASO_RS12180	COG5002	protein histidine kinase activity
NIASO_RS12185	COG0745	RESPONSE REGULATOR receiver
NIASO_RS12230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIASO_RS12250	COG0514	ATP-dependent DNA helicase (RecQ)
NIASO_RS12255	COG2217	Heavy metal translocating P-type atpase
NIASO_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS12295	COG0736	holo-[acyl-carrier-protein] synthase activity
NIASO_RS12300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NIASO_RS12315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NIASO_RS12325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIASO_RS12330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NIASO_RS12355	COG2133	pyrroloquinoline quinone binding
NIASO_RS12370	COG2333	competence protein COMEC
NIASO_RS12370	COG0658	competence protein
NIASO_RS12375	COG0138	bifunctional purine biosynthesis protein purh
NIASO_RS12380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NIASO_RS12395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NIASO_RS12435	COG1612	heme a metabolic process
NIASO_RS12440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NIASO_RS12445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIASO_RS12460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIASO_RS12485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIASO_RS12490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIASO_RS12515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIASO_RS12540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIASO_RS12550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIASO_RS12585	COG1595	DNA-templated transcription, initiation
NIASO_RS12615	COG3590	peptidase
NIASO_RS12630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIASO_RS12635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIASO_RS12640	COG0363	glucosamine-6-phosphate deaminase activity
NIASO_RS12655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NIASO_RS12685	COG0509	glycine decarboxylation via glycine cleavage system
NIASO_RS12700	COG1217	gtp-binding protein TYPA
NIASO_RS12710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIASO_RS12715	COG1597	lipid kinase activity
NIASO_RS12720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NIASO_RS12735	COG3119	arylsulfatase activity
NIASO_RS12740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIASO_RS12765	COG1610	YqeY-like protein
NIASO_RS12790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIASO_RS12795	COG0052	Belongs to the universal ribosomal protein uS2 family
NIASO_RS12800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NIASO_RS12805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NIASO_RS12840	COG0702	epimerase
NIASO_RS12845	COG1629	transport
NIASO_RS12895	COG0702	epimerase
NIASO_RS12900	COG4771	TonB-dependent receptor
NIASO_RS12910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIASO_RS12930	COG0702	epimerase
NIASO_RS12935	COG4771	TonB-dependent receptor
NIASO_RS12950	COG5002	protein histidine kinase activity
NIASO_RS12955	COG0745	RESPONSE REGULATOR receiver
NIASO_RS12970	COG1940	carbohydrate kinase activity
NIASO_RS12975	COG1132	(ABC) transporter
NIASO_RS13020	COG0356	it plays a direct role in the translocation of protons across the membrane
NIASO_RS13025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIASO_RS13030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NIASO_RS13035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIASO_RS13040	COG1011	Hydrolase
NIASO_RS13050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIASO_RS13060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NIASO_RS13070	COG3033	Beta-eliminating lyase
NIASO_RS13085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIASO_RS13110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIASO_RS13115	COG3511	phospholipase C
NIASO_RS13120	COG2270	Major facilitator Superfamily
NIASO_RS13135	COG0113	porphobilinogen synthase activity
NIASO_RS13155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NIASO_RS13170	COG0181	hydroxymethylbilane synthase activity
NIASO_RS13175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NIASO_RS13180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIASO_RS13195	COG2205	protein histidine kinase activity
NIASO_RS13195	COG0784	Response regulator, receiver
NIASO_RS13200	COG1981	membrane
NIASO_RS13215	COG1845	cytochrome c oxidase, subunit III
NIASO_RS13220	COG1845	cytochrome c oxidase, subunit III
NIASO_RS13225	COG0109	protoheme IX farnesyltransferase activity
NIASO_RS13230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIASO_RS13260	COG0437	4 iron, 4 sulfur cluster binding
NIASO_RS13270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIASO_RS13290	COG4771	TonB-dependent receptor
NIASO_RS13310	COG4771	TonB-dependent receptor
NIASO_RS13320	COG3511	phospholipase C
NIASO_RS13345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIASO_RS13355	COG0022	dehydrogenase e1 component
NIASO_RS13370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NIASO_RS13380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIASO_RS13405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIASO_RS13415	COG4771	TonB-dependent receptor
NIASO_RS13420	COG0702	epimerase
NIASO_RS13425	COG2273	Hydrolase Family 16
NIASO_RS13465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIASO_RS13470	COG4636	protein conserved in cyanobacteria
NIASO_RS13480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NIASO_RS13480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NIASO_RS13490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIASO_RS13495	COG1556	Lactate utilization protein
NIASO_RS13515	COG0563	adenylate kinase activity
NIASO_RS13520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIASO_RS13530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIASO_RS13535	COG1136	(ABC) transporter
NIASO_RS13540	COG1136	(ABC) transporter
NIASO_RS13540	COG0577	efflux transmembrane transporter activity
NIASO_RS13560	COG2255	four-way junction helicase activity
NIASO_RS13565	COG0156	8-amino-7-oxononanoate synthase activity
NIASO_RS13590	COG0433	COG0433 Predicted ATPase
NIASO_RS13620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS13625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIASO_RS13635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIASO_RS13640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIASO_RS13660	COG0556	nucleotide-excision repair
NIASO_RS13670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIASO_RS13670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIASO_RS13675	COG2197	response regulator
NIASO_RS13710	COG0668	transmembrane transport
NIASO_RS13715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS13730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS13735	COG1011	Hydrolase
NIASO_RS13760	COG1187	pseudouridine synthase activity
NIASO_RS13765	COG0564	pseudouridine synthase activity
NIASO_RS13790	COG1703	isobutyryl-CoA mutase activity
NIASO_RS13800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NIASO_RS13815	COG3347	Dehydrogenase
NIASO_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS13830	COG1137	ATPase activity
NIASO_RS13835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NIASO_RS13840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIASO_RS13865	COG2194	sulfuric ester hydrolase activity
NIASO_RS13880	COG3655	Transcriptional regulator
NIASO_RS13885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIASO_RS13895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIASO_RS13905	COG0673	inositol 2-dehydrogenase activity
NIASO_RS13920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIASO_RS13935	COG0673	inositol 2-dehydrogenase activity
NIASO_RS13950	COG5434	Belongs to the glycosyl hydrolase 28 family
NIASO_RS13975	COG1629	transport
NIASO_RS13990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIASO_RS13995	COG2045	Belongs to the ComB family
NIASO_RS14000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIASO_RS14015	COG1629	transport
NIASO_RS14015	COG4206	TonB-dependent receptor
NIASO_RS14040	COG4206	TonB-dependent receptor
NIASO_RS14040	COG1629	transport
NIASO_RS14070	COG0306	phosphate transporter
NIASO_RS14075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIASO_RS14080	COG4948	Mandelate Racemase Muconate Lactonizing
NIASO_RS14090	COG2197	response regulator
NIASO_RS14110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIASO_RS14115	COG1695	Transcriptional regulator
NIASO_RS14130	COG1595	DNA-templated transcription, initiation
NIASO_RS14150	COG0673	inositol 2-dehydrogenase activity
NIASO_RS14165	COG3118	belongs to the thioredoxin family
NIASO_RS14170	COG3279	Response regulator of the LytR AlgR family
NIASO_RS14185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NIASO_RS14195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIASO_RS14200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIASO_RS14210	COG0584	glycerophosphoryl diester phosphodiesterase
NIASO_RS14230	COG1629	transport
NIASO_RS14235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NIASO_RS14240	COG1349	DNA-binding transcription factor activity
NIASO_RS14250	COG3537	Alpha-1,2-mannosidase
NIASO_RS14260	COG2315	Protein conserved in bacteria
NIASO_RS14270	COG0251	oxidation-reduction process
NIASO_RS14280	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NIASO_RS14280	COG0662	Cupin 2, conserved barrel domain protein
NIASO_RS14285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NIASO_RS14285	COG0517	IMP dehydrogenase activity
NIASO_RS14290	COG0514	ATP-dependent DNA helicase (RecQ)
NIASO_RS14320	COG0445	tRNA wobble uridine modification
NIASO_RS14325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NIASO_RS14330	COG1918	ferrous iron import across plasma membrane
NIASO_RS14335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NIASO_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS14350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIASO_RS14365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NIASO_RS14370	COG2843	Capsule synthesis protein
NIASO_RS14375	COG0017	Asparaginyl-tRNA synthetase
NIASO_RS14380	COG1649	PFAM Uncharacterised BCR, COG1649
NIASO_RS14390	COG0667	Aldo Keto reductase
NIASO_RS14405	COG1690	Belongs to the RtcB family
NIASO_RS14415	COG1024	Enoyl-CoA hydratase
NIASO_RS14415	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIASO_RS14425	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS14440	COG1629	transport
NIASO_RS14460	COG3408	Glycogen debranching enzyme
NIASO_RS14465	COG3119	arylsulfatase activity
NIASO_RS14475	COG0251	oxidation-reduction process
NIASO_RS14480	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIASO_RS14485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIASO_RS14495	COG0531	amino acid
NIASO_RS14505	COG4977	sequence-specific DNA binding
NIASO_RS14515	COG5434	Belongs to the glycosyl hydrolase 28 family
NIASO_RS14520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS14525	COG1629	transport
NIASO_RS14530	COG0702	epimerase
NIASO_RS14535	COG3119	arylsulfatase activity
NIASO_RS14555	COG3119	arylsulfatase activity
NIASO_RS14560	COG5492	domain, Protein
NIASO_RS14565	COG3119	arylsulfatase activity
NIASO_RS14580	COG3292	Two component regulator propeller
NIASO_RS14580	COG2205	protein histidine kinase activity
NIASO_RS14580	COG0745	RESPONSE REGULATOR receiver
NIASO_RS14585	COG2207	Transcriptional regulator
NIASO_RS14590	COG1629	transport
NIASO_RS14590	COG4206	TonB-dependent receptor
NIASO_RS14605	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NIASO_RS14610	COG2211	Major facilitator Superfamily
NIASO_RS14635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIASO_RS14640	COG1064	alcohol dehydrogenase
NIASO_RS14655	COG0667	Aldo Keto reductase
NIASO_RS14680	COG4771	TonB-dependent receptor
NIASO_RS14690	COG5520	Belongs to the glycosyl hydrolase 30 family
NIASO_RS14695	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS14720	COG0363	glucosamine-6-phosphate deaminase activity
NIASO_RS14755	COG0702	epimerase
NIASO_RS14760	COG1629	transport
NIASO_RS14805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NIASO_RS14815	COG3279	Response regulator of the LytR AlgR family
NIASO_RS14825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS14835	COG4771	TonB-dependent receptor
NIASO_RS14840	COG0702	epimerase
NIASO_RS14855	COG0626	cystathionine gamma-synthase activity
NIASO_RS14860	COG3459	Glycosyltransferase 36 associated
NIASO_RS14885	COG1063	alcohol dehydrogenase
NIASO_RS14900	COG1629	transport
NIASO_RS14910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIASO_RS14920	COG0598	Magnesium transport protein CorA
NIASO_RS14925	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NIASO_RS14950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIASO_RS14970	COG0592	DNA-directed DNA polymerase activity
NIASO_RS15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIASO_RS15015	COG3119	arylsulfatase activity
NIASO_RS15020	COG3119	arylsulfatase activity
NIASO_RS15040	COG1595	DNA-templated transcription, initiation
NIASO_RS15050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIASO_RS15055	COG0483	inositol monophosphate 1-phosphatase activity
NIASO_RS15095	COG3279	Response regulator of the LytR AlgR family
NIASO_RS15105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NIASO_RS15110	COG2154	pterin-4-alpha-carbinolamine dehydratase
NIASO_RS15130	COG0673	inositol 2-dehydrogenase activity
NIASO_RS15135	COG0673	inositol 2-dehydrogenase activity
NIASO_RS15150	COG1349	DNA-binding transcription factor activity
NIASO_RS15155	COG1940	carbohydrate kinase activity
NIASO_RS15160	COG0477	Major facilitator Superfamily
NIASO_RS15165	COG4821	SIS domain
NIASO_RS15185	COG2610	gluconate transmembrane transporter activity
NIASO_RS15195	COG2116	formate transmembrane transporter activity
NIASO_RS15210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIASO_RS15225	COG0315	cyclic pyranopterin monophosphate synthase activity
NIASO_RS15225	COG0521	Mo-molybdopterin cofactor biosynthetic process
NIASO_RS15260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIASO_RS15270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NIASO_RS15285	COG0243	molybdopterin cofactor binding
NIASO_RS15290	COG2223	nitrite transmembrane transporter activity
NIASO_RS15300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIASO_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS15330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIASO_RS15335	COG1040	competence protein
NIASO_RS15340	COG0386	Belongs to the glutathione peroxidase family
NIASO_RS15345	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NIASO_RS15350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIASO_RS15370	COG2824	Alkylphosphonate utilization operon protein PhnA
NIASO_RS15375	COG0697	spore germination
NIASO_RS15400	COG1132	(ABC) transporter
NIASO_RS15425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIASO_RS15425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIASO_RS15435	COG1774	PSP1 C-terminal conserved region
NIASO_RS15450	COG1940	carbohydrate kinase activity
NIASO_RS15455	COG4206	TonB-dependent receptor
NIASO_RS15455	COG1629	transport
NIASO_RS15465	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS15485	COG0025	NhaP-type Na H and K H
NIASO_RS15495	COG1252	NADH dehydrogenase
NIASO_RS15500	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIASO_RS15515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NIASO_RS15525	COG3384	dioxygenase
NIASO_RS15540	COG3279	Response regulator of the LytR AlgR family
NIASO_RS15545	COG3275	phosphorelay sensor kinase activity
NIASO_RS15550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NIASO_RS15565	COG3275	phosphorelay sensor kinase activity
NIASO_RS15570	COG3279	Response regulator of the LytR AlgR family
NIASO_RS15575	COG0612	Peptidase, M16
NIASO_RS15595	COG0495	leucyl-tRNA aminoacylation
NIASO_RS15605	COG1968	undecaprenyl-diphosphatase activity
NIASO_RS15610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIASO_RS15625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NIASO_RS15640	COG2153	protein acetylation
NIASO_RS15645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIASO_RS15650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIASO_RS15655	COG0571	ribonuclease III activity
NIASO_RS15665	COG1104	cysteine desulfurase activity
NIASO_RS15670	COG0750	zinc metalloprotease
NIASO_RS15675	COG3250	beta-galactosidase activity
NIASO_RS15680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NIASO_RS15750	COG0626	cystathionine gamma-synthase activity
NIASO_RS15755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIASO_RS15785	COG1024	Enoyl-CoA hydratase
NIASO_RS15805	COG1131	(ABC) transporter
NIASO_RS15820	COG0629	single-stranded DNA binding
NIASO_RS15830	COG0776	regulation of translation
NIASO_RS15840	COG1530	ribonuclease E activity
NIASO_RS15850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIASO_RS15855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIASO_RS15860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIASO_RS15865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NIASO_RS15880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIASO_RS15885	COG0463	Glycosyl transferase, family 2
NIASO_RS15900	COG1960	acyl-CoA dehydrogenase activity
NIASO_RS15915	COG1609	Transcriptional regulator
NIASO_RS15920	COG1312	Catalyzes the dehydration of D-mannonate
NIASO_RS15950	COG0009	L-threonylcarbamoyladenylate synthase
NIASO_RS15955	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIASO_RS16000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIASO_RS16005	COG2610	gluconate transmembrane transporter activity
NIASO_RS16010	COG1929	Belongs to the glycerate kinase type-1 family
NIASO_RS16045	COG0657	acetylesterase activity
NIASO_RS16045	COG2755	lipolytic protein G-D-S-L family
NIASO_RS16050	COG2186	Transcriptional regulator
NIASO_RS16060	COG4771	TonB-dependent receptor
NIASO_RS16085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIASO_RS16120	COG3177	Filamentation induced by cAMP protein fic
NIASO_RS16125	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NIASO_RS16180	COG3645	SOS response
NIASO_RS16225	COG1846	Transcriptional regulator
NIASO_RS16280	COG1082	Xylose isomerase domain protein TIM barrel
NIASO_RS16285	COG1247	-acetyltransferase
NIASO_RS16295	COG0438	transferase activity, transferring glycosyl groups
NIASO_RS16300	COG0165	Argininosuccinate lyase
NIASO_RS16305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NIASO_RS16310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NIASO_RS16315	COG4804	nuclease activity
NIASO_RS16325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIASO_RS16340	COG1214	PFAM Peptidase M22, glycoprotease
NIASO_RS16345	COG0251	oxidation-reduction process
NIASO_RS16350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIASO_RS16350	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIASO_RS16360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIASO_RS16370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIASO_RS16375	COG1132	(ABC) transporter
NIASO_RS16380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NIASO_RS16390	COG3959	Transketolase, thiamine diphosphate binding domain
NIASO_RS16395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIASO_RS16400	COG0233	cytoplasmic translational termination
NIASO_RS16405	COG1970	mechanosensitive ion channel activity
NIASO_RS16410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NIASO_RS16415	COG1764	response to oxidative stress
NIASO_RS16430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIASO_RS16435	COG0628	permease
NIASO_RS16445	COG1136	(ABC) transporter
NIASO_RS16455	COG0124	histidyl-tRNA synthetase
NIASO_RS16460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIASO_RS16465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIASO_RS16475	COG1950	PFAM Membrane protein of
NIASO_RS16505	COG0779	Required for maturation of 30S ribosomal subunits
NIASO_RS16510	COG0195	Participates in both transcription termination and antitermination
NIASO_RS16515	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NIASO_RS16525	COG0194	GDP metabolic process
NIASO_RS16535	COG0805	protein transport
NIASO_RS16565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NIASO_RS16580	COG0442	prolyl-tRNA aminoacylation
NIASO_RS16585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS16585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIASO_RS16610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS16660	COG1215	transferase activity, transferring glycosyl groups
NIASO_RS16670	COG1472	Belongs to the glycosyl hydrolase 3 family
NIASO_RS16675	COG0745	RESPONSE REGULATOR receiver
NIASO_RS16680	COG5002	protein histidine kinase activity
NIASO_RS16695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS16730	COG1309	transcriptional regulator
NIASO_RS16740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NIASO_RS16745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIASO_RS16780	COG1381	Involved in DNA repair and RecF pathway recombination
NIASO_RS16785	COG0402	S-adenosylhomocysteine deaminase activity
NIASO_RS16790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NIASO_RS16815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIASO_RS16815	COG1648	precorrin-2 dehydrogenase activity
NIASO_RS16820	COG1045	serine acetyltransferase
NIASO_RS16830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIASO_RS16845	COG0175	sulfate reduction
NIASO_RS16850	COG0175	sulfate reduction
NIASO_RS16855	COG0450	alkyl hydroperoxide reductase
NIASO_RS16860	COG1959	2 iron, 2 sulfur cluster binding
NIASO_RS16865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NIASO_RS16885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIASO_RS16895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NIASO_RS16905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIASO_RS16910	COG4591	ABC-type transport system involved in lipoprotein release permease component
NIASO_RS16915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIASO_RS16920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIASO_RS16935	COG0228	four-way junction DNA binding
NIASO_RS16940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIASO_RS16950	COG0604	alcohol dehydrogenase
NIASO_RS16955	COG1741	Belongs to the pirin family
NIASO_RS16970	COG3621	Patatin-like phospholipase
NIASO_RS16975	COG1012	belongs to the aldehyde dehydrogenase family
NIASO_RS16980	COG4106	trans-aconitate 2-methyltransferase activity
NIASO_RS16985	COG1917	Cupin 2, conserved barrel domain protein
NIASO_RS16985	COG2169	Transcriptional regulator
NIASO_RS16990	COG0402	S-adenosylhomocysteine deaminase activity
NIASO_RS16995	COG2814	Major facilitator Superfamily
NIASO_RS17000	COG0758	DNA mediated transformation
NIASO_RS17000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIASO_RS17005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIASO_RS17010	COG0516	GMP reductase activity
NIASO_RS17010	COG0517	IMP dehydrogenase activity
NIASO_RS17020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIASO_RS17020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIASO_RS17065	COG0328	RNA-DNA hybrid ribonuclease activity
NIASO_RS17070	COG1760	l-serine dehydratase
NIASO_RS17105	COG0280	phosphate acetyltransferase
NIASO_RS17105	COG0281	malic enzyme
NIASO_RS17110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIASO_RS17115	COG1127	ABC transporter
NIASO_RS17125	COG2201	protein-glutamate methylesterase activity
NIASO_RS17130	COG0277	FAD linked oxidase domain protein
NIASO_RS17130	COG0247	lactate metabolic process
NIASO_RS17135	COG1234	tRNA 3'-trailer cleavage
NIASO_RS17145	COG0542	response to heat
NIASO_RS17180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIASO_RS17185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS17195	COG0423	glycine-tRNA ligase activity
NIASO_RS17235	COG1234	tRNA 3'-trailer cleavage
NIASO_RS17250	COG1078	dGTPase activity
NIASO_RS17255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIASO_RS17260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NIASO_RS17260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIASO_RS17305	COG4771	TonB-dependent receptor
NIASO_RS17310	COG0702	epimerase
NIASO_RS17320	COG2755	lipolytic protein G-D-S-L family
NIASO_RS17325	COG5434	Belongs to the glycosyl hydrolase 28 family
NIASO_RS17335	COG4677	pectinesterase activity
NIASO_RS17355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS17360	COG0246	Mannitol dehydrogenase
NIASO_RS17365	COG2721	sulfolactate sulfo-lyase activity
NIASO_RS17370	COG1904	glucuronate isomerase
NIASO_RS17375	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS17380	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NIASO_RS17400	COG2271	Major facilitator Superfamily
NIASO_RS17405	COG1917	Cupin 2, conserved barrel domain protein
NIASO_RS17425	COG1022	Amp-dependent synthetase and ligase
NIASO_RS17445	COG1309	transcriptional regulator
NIASO_RS17455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIASO_RS17470	COG0724	RNA recognition motif
NIASO_RS17475	COG0359	binds to the 23S rRNA
NIASO_RS17480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NIASO_RS17485	COG0360	Binds together with S18 to 16S ribosomal RNA
NIASO_RS17495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIASO_RS17495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIASO_RS17500	COG0142	geranyltranstransferase activity
NIASO_RS17515	COG0067	glutamate synthase
NIASO_RS17515	COG0069	glutamate synthase activity
NIASO_RS17515	COG0070	glutamate synthase
NIASO_RS17525	COG3408	Glycogen debranching enzyme
NIASO_RS17530	COG3265	gluconokinase activity
NIASO_RS17540	COG4771	TonB-dependent receptor
NIASO_RS17585	COG4771	TonB-dependent receptor
NIASO_RS17590	COG0702	epimerase
NIASO_RS17595	COG3119	arylsulfatase activity
NIASO_RS17605	COG3119	arylsulfatase activity
NIASO_RS17610	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIASO_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS17625	COG4948	Mandelate Racemase Muconate Lactonizing
NIASO_RS17655	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIASO_RS17660	COG0512	Glutamine amidotransferase of anthranilate synthase
NIASO_RS17665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIASO_RS17670	COG0134	indole-3-glycerol-phosphate synthase activity
NIASO_RS17675	COG0135	phosphoribosylanthranilate isomerase activity
NIASO_RS17730	COG0133	tryptophan synthase activity
NIASO_RS17735	COG0159	tryptophan synthase activity
NIASO_RS17740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS17750	COG3548	integral membrane protein
NIASO_RS17755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NIASO_RS17760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIASO_RS17760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIASO_RS17785	COG3132	Protein of unknown function, DUF480
NIASO_RS17795	COG4206	TonB-dependent receptor
NIASO_RS17805	COG0653	protein targeting
NIASO_RS17815	COG1368	sulfuric ester hydrolase activity
NIASO_RS17830	COG0730	response to heat
NIASO_RS17835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIASO_RS17840	COG0302	gtp cyclohydrolase
NIASO_RS17860	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NIASO_RS17900	COG1506	peptidase
NIASO_RS17900	COG0823	Involved in the tonB-independent uptake of proteins
NIASO_RS17905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIASO_RS17910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NIASO_RS17915	COG4221	oxidoreductase activity
NIASO_RS17920	COG0596	Alpha beta hydrolase
NIASO_RS17925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NIASO_RS17930	COG0322	excinuclease ABC activity
NIASO_RS17935	COG4804	nuclease activity
NIASO_RS17945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIASO_RS17960	COG0023	Translation Initiation Factor
NIASO_RS17970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NIASO_RS17990	COG2378	regulation of single-species biofilm formation
NIASO_RS18000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIASO_RS18020	COG1119	ATPase activity
NIASO_RS18025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NIASO_RS18050	COG0028	Belongs to the TPP enzyme family
NIASO_RS18055	COG2318	DinB family
NIASO_RS18070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIASO_RS18095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIASO_RS18095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIASO_RS18110	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIASO_RS18115	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIASO_RS18120	COG1301	dicarboxylic acid transport
NIASO_RS18125	COG0475	glutathione-regulated potassium exporter activity
NIASO_RS18125	COG0589	response to stress
NIASO_RS18135	COG2001	Belongs to the MraZ family
NIASO_RS18140	COG0275	rRNA processing
NIASO_RS18155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIASO_RS18160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIASO_RS18165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NIASO_RS18170	COG0772	Belongs to the SEDS family
NIASO_RS18175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIASO_RS18180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIASO_RS18185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NIASO_RS18195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIASO_RS18210	COG0439	Biotin carboxylase
NIASO_RS18220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NIASO_RS18270	COG0606	chelatase, subunit chli
NIASO_RS18280	COG1132	(ABC) transporter
NIASO_RS18285	COG1104	cysteine desulfurase activity
NIASO_RS18290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIASO_RS18295	COG0671	phosphoesterase, PA-phosphatase related
NIASO_RS18300	COG1253	flavin adenine dinucleotide binding
NIASO_RS18355	COG0183	Belongs to the thiolase family
NIASO_RS18360	COG1349	DNA-binding transcription factor activity
NIASO_RS18365	COG1629	transport
NIASO_RS18375	COG4206	TonB-dependent receptor
NIASO_RS18375	COG1629	transport
NIASO_RS18385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIASO_RS18390	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NIASO_RS18405	COG1331	Highly conserved protein containing a thioredoxin domain
NIASO_RS18445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIASO_RS18470	COG0012	GTP binding
NIASO_RS18475	COG2715	membrane protein required for spore maturation
NIASO_RS18500	COG0460	homoserine dehydrogenase
NIASO_RS18500	COG0527	aspartate kinase activity
NIASO_RS18505	COG0083	homoserine kinase activity
NIASO_RS18510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIASO_RS18530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NIASO_RS18545	COG0673	inositol 2-dehydrogenase activity
NIASO_RS18570	COG3250	beta-galactosidase activity
NIASO_RS18580	COG3250	beta-galactosidase activity
NIASO_RS18590	COG1629	transport
NIASO_RS18595	COG0702	epimerase
NIASO_RS18615	COG1609	Transcriptional regulator
NIASO_RS18620	COG4771	TonB-dependent receptor
NIASO_RS18650	COG3959	Transketolase, thiamine diphosphate binding domain
NIASO_RS18655	COG3958	Transketolase
NIASO_RS18670	COG1129	ABC transporter
NIASO_RS18675	COG1172	Belongs to the binding-protein-dependent transport system permease family
NIASO_RS18680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIASO_RS18695	COG3250	beta-galactosidase activity
NIASO_RS18700	COG3408	Glycogen debranching enzyme
NIASO_RS18715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIASO_RS18735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIASO_RS18790	COG0385	Bile acid
NIASO_RS18795	COG3250	beta-galactosidase activity
NIASO_RS18800	COG3940	Belongs to the glycosyl hydrolase 43 family
NIASO_RS18840	COG3119	arylsulfatase activity
NIASO_RS18860	COG0346	lactoylglutathione lyase activity
NIASO_RS18880	COG3956	TIGRFAM MazG family protein
NIASO_RS18885	COG5000	phosphorelay sensor kinase activity
NIASO_RS18890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NIASO_RS18890	COG1796	DNA polymerase
NIASO_RS18900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NIASO_RS18905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NIASO_RS18915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NIASO_RS18925	COG0326	Molecular chaperone. Has ATPase activity
NIASO_RS18950	COG4771	TonB-dependent receptor
NIASO_RS19000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NIASO_RS19030	COG0579	oxidoreductase
NIASO_RS19060	COG1028	Short-chain dehydrogenase reductase Sdr
NIASO_RS19060	COG3347	Dehydrogenase
NIASO_RS19065	COG4952	isomerase
NIASO_RS19095	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
NIASO_RS19130	COG3278	Belongs to the heme-copper respiratory oxidase family
NIASO_RS19135	COG1959	2 iron, 2 sulfur cluster binding
NIASO_RS19140	COG1621	beta-fructofuranosidase activity
NIASO_RS19165	COG2837	iron assimilation
NIASO_RS19185	COG1629	transport
NIASO_RS19200	COG2197	response regulator
NIASO_RS19265	COG1609	Transcriptional regulator
NIASO_RS19270	COG1629	transport
NIASO_RS19275	COG0702	epimerase
NIASO_RS19290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIASO_RS19295	COG4948	Mandelate Racemase Muconate Lactonizing
NIASO_RS19300	COG2814	Major facilitator Superfamily
NIASO_RS19300	COG0477	Major facilitator Superfamily
NIASO_RS19340	COG0861	Integral membrane protein TerC family
NIASO_RS19345	COG0167	dihydroorotate dehydrogenase activity
NIASO_RS19350	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NIASO_RS19385	COG0539	negative regulation of cytoplasmic translation
NIASO_RS19385	COG2183	response to ionizing radiation
NIASO_RS19390	COG2353	YceI-like domain
NIASO_RS19400	COG2132	Multicopper oxidase
NIASO_RS19415	COG0656	L-ascorbic acid biosynthetic process
NIASO_RS19420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIASO_RS19440	COG0488	(ABC) transporter
NIASO_RS19450	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIASO_RS19470	COG1428	Deoxynucleoside kinase
NIASO_RS19480	COG0616	signal peptide processing
NIASO_RS19485	COG0842	Transport permease protein
NIASO_RS19500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIASO_RS19505	COG1446	asparaginase
NIASO_RS19510	COG0542	response to heat
NIASO_RS19515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIASO_RS19515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIASO_RS19560	COG3794	PFAM blue (type 1) copper domain protein
NIASO_RS19665	COG2010	Cytochrome c
NIASO_RS19730	COG1215	transferase activity, transferring glycosyl groups
NIASO_RS19740	COG3275	phosphorelay sensor kinase activity
NIASO_RS19745	COG3275	phosphorelay sensor kinase activity
NIASO_RS19765	COG0746	molybdenum cofactor guanylyltransferase activity
NIASO_RS19830	COG1215	transferase activity, transferring glycosyl groups
NIASO_RS19835	COG3292	Two component regulator propeller
NIASO_RS19835	COG2205	protein histidine kinase activity
NIASO_RS19835	COG0745	RESPONSE REGULATOR receiver
NIASO_RS19860	COG0791	NLP P60 protein
NIASO_RS19940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NIASO_RS19955	COG0594	ribonuclease P activity