locus-tag	class	description
A8C56_RS00010	COG4804	nuclease activity
A8C56_RS00025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A8C56_RS00035	COG1214	PFAM Peptidase M22, glycoprotease
A8C56_RS00045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A8C56_RS00045	COG0674	pyruvate-flavodoxin oxidoreductase activity
A8C56_RS00065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8C56_RS00085	COG1132	(ABC) transporter
A8C56_RS00090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A8C56_RS00100	COG3959	Transketolase, thiamine diphosphate binding domain
A8C56_RS00105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8C56_RS00110	COG0233	cytoplasmic translational termination
A8C56_RS00115	COG1970	mechanosensitive ion channel activity
A8C56_RS00120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A8C56_RS00125	COG1764	response to oxidative stress
A8C56_RS00130	COG2234	aminopeptidase activity
A8C56_RS00135	COG0698	ribose 5-phosphate isomerase
A8C56_RS00140	COG0805	protein transport
A8C56_RS00145	COG1253	flavin adenine dinucleotide binding
A8C56_RS00150	COG0194	GDP metabolic process
A8C56_RS00160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A8C56_RS00165	COG0195	Participates in both transcription termination and antitermination
A8C56_RS00170	COG0779	Required for maturation of 30S ribosomal subunits
A8C56_RS00200	COG1950	PFAM Membrane protein of
A8C56_RS00225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A8C56_RS00230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A8C56_RS00235	COG0124	histidyl-tRNA synthetase
A8C56_RS00245	COG1136	(ABC) transporter
A8C56_RS00255	COG0628	permease
A8C56_RS00260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A8C56_RS00275	COG2217	Heavy metal translocating P-type atpase
A8C56_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS00325	COG0736	holo-[acyl-carrier-protein] synthase activity
A8C56_RS00330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A8C56_RS00335	COG0594	ribonuclease P activity
A8C56_RS00350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A8C56_RS00365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A8C56_RS00370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A8C56_RS00410	COG2133	pyrroloquinoline quinone binding
A8C56_RS00425	COG2333	competence protein COMEC
A8C56_RS00425	COG0658	competence protein
A8C56_RS00430	COG0138	bifunctional purine biosynthesis protein purh
A8C56_RS00440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS00455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C56_RS00460	COG0702	epimerase
A8C56_RS00465	COG1629	transport
A8C56_RS00470	COG0514	ATP-dependent DNA helicase (RecQ)
A8C56_RS00490	COG0442	prolyl-tRNA aminoacylation
A8C56_RS00500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS00525	COG1819	glycosyl
A8C56_RS00550	COG1733	regulation of RNA biosynthetic process
A8C56_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS00580	COG1472	Belongs to the glycosyl hydrolase 3 family
A8C56_RS00585	COG0745	RESPONSE REGULATOR receiver
A8C56_RS00615	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS00625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A8C56_RS00650	COG1611	Belongs to the LOG family
A8C56_RS00655	COG0708	Exodeoxyribonuclease III
A8C56_RS00690	COG0528	UMP kinase activity
A8C56_RS00695	COG0667	Aldo Keto reductase
A8C56_RS00705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C56_RS00715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A8C56_RS00715	COG0617	tRNA 3'-terminal CCA addition
A8C56_RS00715	COG0517	IMP dehydrogenase activity
A8C56_RS00720	COG0009	L-threonylcarbamoyladenylate synthase
A8C56_RS00730	COG2171	N-acyltransferase activity
A8C56_RS00735	COG1162	GTPase activity
A8C56_RS00740	COG1373	ATPase (AAA superfamily
A8C56_RS00745	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A8C56_RS00755	COG1660	Displays ATPase and GTPase activities
A8C56_RS00785	COG0667	Aldo Keto reductase
A8C56_RS00820	COG0688	phosphatidylethanolamine metabolic process
A8C56_RS00825	COG0450	alkyl hydroperoxide reductase
A8C56_RS00845	COG0791	NLP P60 protein
A8C56_RS00865	COG2304	oxidoreductase activity
A8C56_RS00910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS00915	COG4464	protein tyrosine phosphatase activity
A8C56_RS00920	COG1595	DNA-templated transcription, initiation
A8C56_RS00925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C56_RS00935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A8C56_RS00940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C56_RS00955	COG4771	TonB-dependent receptor
A8C56_RS00980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A8C56_RS00985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A8C56_RS00990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A8C56_RS00995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A8C56_RS01000	COG0202	RNA polymerase activity
A8C56_RS01005	COG0203	ribosomal protein L17
A8C56_RS01010	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A8C56_RS01015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A8C56_RS01025	COG3408	Glycogen debranching enzyme
A8C56_RS01040	COG4993	Dehydrogenase
A8C56_RS01050	COG1629	transport
A8C56_RS01095	COG2188	Transcriptional regulator
A8C56_RS01100	COG2271	Major facilitator Superfamily
A8C56_RS01110	COG4771	TonB-dependent receptor
A8C56_RS01115	COG0702	epimerase
A8C56_RS01145	COG1595	DNA-templated transcription, initiation
A8C56_RS01150	COG3958	Transketolase
A8C56_RS01165	COG1077	Cell shape determining protein MreB Mrl
A8C56_RS01185	COG0423	glycine-tRNA ligase activity
A8C56_RS01205	COG4206	TonB-dependent receptor
A8C56_RS01205	COG1629	transport
A8C56_RS01210	COG0702	epimerase
A8C56_RS01225	COG2116	formate transmembrane transporter activity
A8C56_RS01235	COG2146	nitrite reductase [NAD(P)H] activity
A8C56_RS01240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A8C56_RS01245	COG1648	precorrin-2 dehydrogenase activity
A8C56_RS01245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8C56_RS01260	COG0243	molybdopterin cofactor binding
A8C56_RS01265	COG2223	nitrite transmembrane transporter activity
A8C56_RS01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C56_RS01275	COG1073	alpha beta
A8C56_RS01300	COG1078	dGTPase activity
A8C56_RS01305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS01310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8C56_RS01310	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A8C56_RS01315	COG1760	l-serine dehydratase
A8C56_RS01355	COG0280	phosphate acetyltransferase
A8C56_RS01355	COG0281	malic enzyme
A8C56_RS01360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A8C56_RS01365	COG1127	ABC transporter
A8C56_RS01375	COG2201	protein-glutamate methylesterase activity
A8C56_RS01380	COG0277	FAD linked oxidase domain protein
A8C56_RS01380	COG0247	lactate metabolic process
A8C56_RS01385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8C56_RS01425	COG4771	TonB-dependent receptor
A8C56_RS01465	COG0730	response to heat
A8C56_RS01475	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C56_RS01480	COG4221	oxidoreductase activity
A8C56_RS01485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C56_RS01490	COG4206	TonB-dependent receptor
A8C56_RS01490	COG1629	transport
A8C56_RS01520	COG2855	membrane
A8C56_RS01545	COG0673	inositol 2-dehydrogenase activity
A8C56_RS01565	COG4771	TonB-dependent receptor
A8C56_RS01585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8C56_RS01590	COG0512	Glutamine amidotransferase of anthranilate synthase
A8C56_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A8C56_RS01600	COG0134	indole-3-glycerol-phosphate synthase activity
A8C56_RS01605	COG0135	phosphoribosylanthranilate isomerase activity
A8C56_RS01645	COG0133	tryptophan synthase activity
A8C56_RS01650	COG0159	tryptophan synthase activity
A8C56_RS01655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS01680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C56_RS01685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C56_RS01695	COG2211	Major facilitator Superfamily
A8C56_RS01700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A8C56_RS01720	COG4206	TonB-dependent receptor
A8C56_RS01740	COG2814	Major facilitator Superfamily
A8C56_RS01745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8C56_RS01755	COG0653	protein targeting
A8C56_RS01765	COG1368	sulfuric ester hydrolase activity
A8C56_RS01780	COG0730	response to heat
A8C56_RS01785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A8C56_RS01790	COG0302	gtp cyclohydrolase
A8C56_RS01805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A8C56_RS01810	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A8C56_RS01815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A8C56_RS01865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A8C56_RS01875	COG0322	excinuclease ABC activity
A8C56_RS01890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A8C56_RS01900	COG4221	oxidoreductase activity
A8C56_RS01905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A8C56_RS01915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A8C56_RS01925	COG0823	Involved in the tonB-independent uptake of proteins
A8C56_RS01925	COG1506	peptidase
A8C56_RS01935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A8C56_RS01960	COG2378	regulation of single-species biofilm formation
A8C56_RS01970	COG4771	TonB-dependent receptor
A8C56_RS01995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A8C56_RS02010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A8C56_RS02035	COG4106	trans-aconitate 2-methyltransferase activity
A8C56_RS02045	COG0028	Belongs to the TPP enzyme family
A8C56_RS02050	COG2318	DinB family
A8C56_RS02070	COG0129	dihydroxy-acid dehydratase activity
A8C56_RS02080	COG1119	ATPase activity
A8C56_RS02085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A8C56_RS02110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C56_RS02110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A8C56_RS02120	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8C56_RS02125	COG1619	proteins homologs of microcin C7 resistance protein MccF
A8C56_RS02135	COG3158	transport of potassium into the cell
A8C56_RS02150	COG0047	phosphoribosylformylglycinamidine synthase activity
A8C56_RS02160	COG0163	prenyltransferase activity
A8C56_RS02180	COG0156	8-amino-7-oxononanoate synthase activity
A8C56_RS02185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A8C56_RS02190	COG1809	phosphosulfolactate synthase activity
A8C56_RS02195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A8C56_RS02200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8C56_RS02210	COG0671	phosphoesterase, PA-phosphatase related
A8C56_RS02215	COG1253	flavin adenine dinucleotide binding
A8C56_RS02270	COG1132	(ABC) transporter
A8C56_RS02280	COG0183	Belongs to the thiolase family
A8C56_RS02285	COG1349	DNA-binding transcription factor activity
A8C56_RS02290	COG1629	transport
A8C56_RS02290	COG4206	TonB-dependent receptor
A8C56_RS02305	COG1349	DNA-binding transcription factor activity
A8C56_RS02310	COG4771	TonB-dependent receptor
A8C56_RS02325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C56_RS02330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A8C56_RS02345	COG1331	Highly conserved protein containing a thioredoxin domain
A8C56_RS02355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A8C56_RS02360	COG4585	Histidine kinase
A8C56_RS02365	COG2197	response regulator
A8C56_RS02390	COG5002	protein histidine kinase activity
A8C56_RS02395	COG3292	Two component regulator propeller
A8C56_RS02395	COG0745	RESPONSE REGULATOR receiver
A8C56_RS02395	COG2205	protein histidine kinase activity
A8C56_RS02425	COG2715	membrane protein required for spore maturation
A8C56_RS02430	COG0288	reversible hydration of carbon dioxide
A8C56_RS02435	COG0659	secondary active sulfate transmembrane transporter activity
A8C56_RS02450	COG0477	Major facilitator Superfamily
A8C56_RS02485	COG0657	acetylesterase activity
A8C56_RS02485	COG2755	lipolytic protein G-D-S-L family
A8C56_RS02515	COG1629	transport
A8C56_RS02525	COG3119	arylsulfatase activity
A8C56_RS02530	COG3119	arylsulfatase activity
A8C56_RS02535	COG3119	arylsulfatase activity
A8C56_RS02560	COG4771	TonB-dependent receptor
A8C56_RS02590	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A8C56_RS02595	COG1082	Xylose isomerase domain protein TIM barrel
A8C56_RS02600	COG1196	nuclear chromosome segregation
A8C56_RS02615	COG3537	Alpha-1,2-mannosidase
A8C56_RS02660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8C56_RS02680	COG1459	type II secretion system
A8C56_RS02760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A8C56_RS02865	COG1476	TRANSCRIPTIONal
A8C56_RS02910	COG4680	protein conserved in bacteria
A8C56_RS03045	COG4771	TonB-dependent receptor
A8C56_RS03080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A8C56_RS03090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A8C56_RS03110	COG0504	CTP synthase activity
A8C56_RS03115	COG0706	membrane insertase activity
A8C56_RS03120	COG2346	COG2346, Truncated hemoglobins
A8C56_RS03125	COG3189	MarR family transcriptional regulator
A8C56_RS03165	COG3275	phosphorelay sensor kinase activity
A8C56_RS03175	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A8C56_RS03190	COG1611	Belongs to the LOG family
A8C56_RS03205	COG4145	pantothenate transmembrane transporter activity
A8C56_RS03220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A8C56_RS03235	COG2808	Putative FMN-binding domain
A8C56_RS03255	COG0436	Aminotransferase
A8C56_RS03260	COG1418	mRNA catabolic process
A8C56_RS03265	COG1473	amidohydrolase
A8C56_RS03295	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
A8C56_RS03300	COG1546	Belongs to the CinA family
A8C56_RS03300	COG1058	Belongs to the CinA family
A8C56_RS03315	COG1428	Deoxynucleoside kinase
A8C56_RS03335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A8C56_RS03350	COG0542	response to heat
A8C56_RS03355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A8C56_RS03355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8C56_RS03360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A8C56_RS03375	COG0346	lactoylglutathione lyase activity
A8C56_RS03390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A8C56_RS03395	COG1335	isochorismatase
A8C56_RS03415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A8C56_RS03425	COG0693	protein deglycase activity
A8C56_RS03435	COG2204	response regulator
A8C56_RS03470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A8C56_RS03475	COG2363	Small membrane protein
A8C56_RS03485	COG1674	ftsk spoiiie
A8C56_RS03510	COG4771	TonB-dependent receptor
A8C56_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS03540	COG0387	Pfam Sodium calcium exchanger
A8C56_RS03545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8C56_RS03550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS03560	COG4771	TonB-dependent receptor
A8C56_RS03570	COG0045	succinate-CoA ligase (ADP-forming) activity
A8C56_RS03590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS03595	COG1609	Transcriptional regulator
A8C56_RS03605	COG0357	Ribosomal RNA small subunit methyltransferase G
A8C56_RS03610	COG0305	Participates in initiation and elongation during chromosome replication
A8C56_RS03615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A8C56_RS03640	COG4585	Histidine kinase
A8C56_RS03675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A8C56_RS03680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A8C56_RS03700	COG0583	DNA-binding transcription factor activity
A8C56_RS03715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A8C56_RS03720	COG0010	Belongs to the arginase family
A8C56_RS03730	COG0025	NhaP-type Na H and K H
A8C56_RS03775	COG0488	(ABC) transporter
A8C56_RS03795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A8C56_RS03820	COG1960	acyl-CoA dehydrogenase activity
A8C56_RS03825	COG4770	biotin carboxylase activity
A8C56_RS03830	COG1024	Enoyl-CoA hydratase
A8C56_RS03835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A8C56_RS03850	COG3511	phospholipase C
A8C56_RS03860	COG0024	Methionine aminopeptidase
A8C56_RS03910	COG1360	Flagellar Motor Protein
A8C56_RS03915	COG0527	aspartate kinase activity
A8C56_RS03915	COG0460	homoserine dehydrogenase
A8C56_RS03920	COG0083	homoserine kinase activity
A8C56_RS03925	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A8C56_RS03940	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A8C56_RS03985	COG3250	beta-galactosidase activity
A8C56_RS03990	COG3408	Glycogen debranching enzyme
A8C56_RS04000	COG3250	beta-galactosidase activity
A8C56_RS04010	COG1629	transport
A8C56_RS04015	COG0702	epimerase
A8C56_RS04050	COG0673	inositol 2-dehydrogenase activity
A8C56_RS04070	COG3250	beta-galactosidase activity
A8C56_RS04075	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS04095	COG3119	arylsulfatase activity
A8C56_RS04100	COG3119	arylsulfatase activity
A8C56_RS04140	COG0101	tRNA pseudouridine synthase activity
A8C56_RS04195	COG4771	TonB-dependent receptor
A8C56_RS04215	COG4771	TonB-dependent receptor
A8C56_RS04230	COG4771	TonB-dependent receptor
A8C56_RS04240	COG2271	Major facilitator Superfamily
A8C56_RS04245	COG2081	HI0933 family
A8C56_RS04255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A8C56_RS04260	COG1349	DNA-binding transcription factor activity
A8C56_RS04265	COG2814	Major facilitator Superfamily
A8C56_RS04270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C56_RS04275	COG1070	Carbohydrate kinase
A8C56_RS04280	COG1070	Carbohydrate kinase
A8C56_RS04285	COG0588	phosphoglycerate mutase activity
A8C56_RS04295	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS04340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C56_RS04385	COG3250	beta-galactosidase activity
A8C56_RS04395	COG3250	beta-galactosidase activity
A8C56_RS04425	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A8C56_RS04440	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A8C56_RS04455	COG0724	RNA recognition motif
A8C56_RS04485	COG1295	ribonuclease BN
A8C56_RS04490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A8C56_RS04515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A8C56_RS04520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS04530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A8C56_RS04535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8C56_RS04540	COG1285	pathogenesis
A8C56_RS04555	COG4166	transmembrane transport
A8C56_RS04575	COG1940	carbohydrate kinase activity
A8C56_RS04585	COG0297	glycogen (starch) synthase activity
A8C56_RS04590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A8C56_RS04600	COG0366	Alpha amylase catalytic
A8C56_RS04625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A8C56_RS04635	COG0058	SHG alpha-glucan phosphorylase activity
A8C56_RS04640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A8C56_RS04645	COG0366	Alpha amylase catalytic
A8C56_RS04655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C56_RS04665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A8C56_RS04670	COG1181	Belongs to the D-alanine--D-alanine ligase family
A8C56_RS04675	COG2815	serine threonine protein kinase
A8C56_RS04675	COG0515	serine threonine protein kinase
A8C56_RS04690	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C56_RS04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C56_RS04715	COG0632	four-way junction helicase activity
A8C56_RS04725	COG3239	Fatty acid desaturase
A8C56_RS04730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A8C56_RS04770	COG1222	aaa ATPase
A8C56_RS04875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8C56_RS04885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C56_RS04890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A8C56_RS04895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A8C56_RS04900	COG0242	peptide deformylase activity
A8C56_RS04915	COG0051	transcription antitermination factor activity, RNA binding
A8C56_RS04920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A8C56_RS04925	COG0088	Forms part of the polypeptide exit tunnel
A8C56_RS04930	COG0089	rRNA binding
A8C56_RS04935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A8C56_RS04940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A8C56_RS04945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A8C56_RS04950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A8C56_RS04955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A8C56_RS04960	COG0255	Belongs to the universal ribosomal protein uL29 family
A8C56_RS04965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A8C56_RS04970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A8C56_RS04975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A8C56_RS04980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A8C56_RS04985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A8C56_RS04990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A8C56_RS04995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A8C56_RS05000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A8C56_RS05005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A8C56_RS05010	COG1841	ribosomal large subunit assembly
A8C56_RS05015	COG0200	Binds to the 23S rRNA
A8C56_RS05025	COG0024	Methionine aminopeptidase
A8C56_RS05040	COG4221	oxidoreductase activity
A8C56_RS05040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A8C56_RS05040	COG3321	synthase
A8C56_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS05060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C56_RS05080	COG0110	maltose O-acetyltransferase activity
A8C56_RS05150	COG2226	methyltransferase
A8C56_RS05165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A8C56_RS05170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8C56_RS05175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8C56_RS05205	COG0793	Belongs to the peptidase S41A family
A8C56_RS05220	COG0268	Binds directly to 16S ribosomal RNA
A8C56_RS05230	COG2197	response regulator
A8C56_RS05235	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C56_RS05330	COG1228	amidohydrolase
A8C56_RS05345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C56_RS05355	COG1228	amidohydrolase
A8C56_RS05370	COG5434	Belongs to the glycosyl hydrolase 28 family
A8C56_RS05375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS05380	COG1629	transport
A8C56_RS05385	COG0702	epimerase
A8C56_RS05395	COG3119	arylsulfatase activity
A8C56_RS05400	COG1940	carbohydrate kinase activity
A8C56_RS05420	COG3119	arylsulfatase activity
A8C56_RS05430	COG3119	arylsulfatase activity
A8C56_RS05430	COG3408	Glycogen debranching enzyme
A8C56_RS05440	COG0745	RESPONSE REGULATOR receiver
A8C56_RS05440	COG3292	Two component regulator propeller
A8C56_RS05440	COG2205	protein histidine kinase activity
A8C56_RS05465	COG0484	heat shock protein binding
A8C56_RS05485	COG0314	molybdopterin synthase activity
A8C56_RS05490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A8C56_RS05520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A8C56_RS05530	COG0315	cyclic pyranopterin monophosphate synthase activity
A8C56_RS05530	COG0746	molybdenum cofactor guanylyltransferase activity
A8C56_RS05535	COG0315	cyclic pyranopterin monophosphate synthase activity
A8C56_RS05540	COG0303	'Molybdopterin
A8C56_RS05545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A8C56_RS05555	COG0443	Heat shock 70 kDa protein
A8C56_RS05575	COG1012	belongs to the aldehyde dehydrogenase family
A8C56_RS05595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A8C56_RS05605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A8C56_RS05615	COG0494	nUDIX hydrolase
A8C56_RS05645	COG0482	sulfurtransferase activity
A8C56_RS05650	COG0629	single-stranded DNA binding
A8C56_RS05675	COG0527	aspartate kinase activity
A8C56_RS05705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8C56_RS05710	COG0436	Aminotransferase
A8C56_RS05720	COG1629	transport
A8C56_RS05775	COG1505	serine-type exopeptidase activity
A8C56_RS05785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A8C56_RS05795	COG2032	superoxide dismutase activity
A8C56_RS05810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C56_RS05815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A8C56_RS05850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C56_RS05855	COG0673	inositol 2-dehydrogenase activity
A8C56_RS05870	COG2755	lipolytic protein G-D-S-L family
A8C56_RS05880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A8C56_RS05885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A8C56_RS05900	COG1166	arginine decarboxylase activity
A8C56_RS05945	COG4771	TonB-dependent receptor
A8C56_RS05950	COG0702	epimerase
A8C56_RS05975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A8C56_RS05985	COG1138	Cytochrome C-type biogenesis protein
A8C56_RS05995	COG0316	Belongs to the HesB IscA family
A8C56_RS06000	COG2226	methyltransferase
A8C56_RS06015	COG1522	sequence-specific DNA binding
A8C56_RS06020	COG0697	spore germination
A8C56_RS06025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A8C56_RS06035	COG0069	glutamate synthase activity
A8C56_RS06045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A8C56_RS06080	COG1629	transport
A8C56_RS06085	COG0702	epimerase
A8C56_RS06095	COG3250	beta-galactosidase activity
A8C56_RS06115	COG0730	response to heat
A8C56_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS06150	COG1629	transport
A8C56_RS06180	COG3206	protein involved in exopolysaccharide biosynthesis
A8C56_RS06180	COG0489	protein tyrosine kinase activity
A8C56_RS06190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS06195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A8C56_RS06200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A8C56_RS06250	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS06265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A8C56_RS06295	COG0531	amino acid
A8C56_RS06300	COG1301	dicarboxylic acid transport
A8C56_RS06305	COG0586	Pfam SNARE associated Golgi protein
A8C56_RS06315	COG1472	Belongs to the glycosyl hydrolase 3 family
A8C56_RS06320	COG0564	pseudouridine synthase activity
A8C56_RS06330	COG0321	lipoyl(octanoyl) transferase activity
A8C56_RS06340	COG0077	Prephenate dehydratase
A8C56_RS06340	COG1605	Chorismate mutase
A8C56_RS06350	COG0287	Prephenate dehydrogenase
A8C56_RS06355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A8C56_RS06360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A8C56_RS06365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A8C56_RS06370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8C56_RS06375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A8C56_RS06380	COG2261	transglycosylase associated protein
A8C56_RS06415	COG0788	formyltetrahydrofolate deformylase activity
A8C56_RS06420	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A8C56_RS06435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A8C56_RS06440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A8C56_RS06465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A8C56_RS06495	COG0488	(ABC) transporter
A8C56_RS06500	COG2312	Erythromycin esterase
A8C56_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS06530	COG3275	phosphorelay sensor kinase activity
A8C56_RS06535	COG3279	Response regulator of the LytR AlgR family
A8C56_RS06545	COG0484	heat shock protein binding
A8C56_RS06560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A8C56_RS06580	COG0307	riboflavin synthase, alpha
A8C56_RS06585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A8C56_RS06590	COG4974	Belongs to the 'phage' integrase family
A8C56_RS06625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A8C56_RS06630	COG1160	GTP binding
A8C56_RS06640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A8C56_RS06645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A8C56_RS06650	COG2239	Acts as a magnesium transporter
A8C56_RS06695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C56_RS06720	COG0540	Belongs to the ATCase OTCase family
A8C56_RS06725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A8C56_RS06730	COG0492	ferredoxin-NADP+ reductase activity
A8C56_RS06745	COG1609	Transcriptional regulator
A8C56_RS06765	COG1254	Belongs to the acylphosphatase family
A8C56_RS06770	COG1956	GAF domain-containing protein
A8C56_RS06780	COG0405	Gamma-glutamyltransferase
A8C56_RS06810	COG1660	Displays ATPase and GTPase activities
A8C56_RS06815	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A8C56_RS06820	COG2081	HI0933 family
A8C56_RS06825	COG0745	RESPONSE REGULATOR receiver
A8C56_RS06830	COG0745	RESPONSE REGULATOR receiver
A8C56_RS06830	COG2205	protein histidine kinase activity
A8C56_RS06830	COG3292	Two component regulator propeller
A8C56_RS06835	COG4771	TonB-dependent receptor
A8C56_RS06845	COG0702	epimerase
A8C56_RS06850	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS06860	COG4206	TonB-dependent receptor
A8C56_RS06860	COG1629	transport
A8C56_RS06915	COG3250	beta-galactosidase activity
A8C56_RS06925	COG0248	Ppx GppA phosphatase
A8C56_RS06930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A8C56_RS06940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C56_RS06945	COG1666	GTP binding
A8C56_RS06950	COG0254	rRNA binding
A8C56_RS06960	COG0149	triose-phosphate isomerase activity
A8C56_RS06985	COG0505	Belongs to the CarA family
A8C56_RS07015	COG1215	transferase activity, transferring glycosyl groups
A8C56_RS07080	COG0702	epimerase
A8C56_RS07085	COG4771	TonB-dependent receptor
A8C56_RS07095	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS07100	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS07160	COG4585	Histidine kinase
A8C56_RS07170	COG1959	2 iron, 2 sulfur cluster binding
A8C56_RS07175	COG2151	metal-sulfur cluster biosynthetic enzyme
A8C56_RS07180	COG2166	iron-sulfur cluster assembly
A8C56_RS07195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A8C56_RS07200	COG0719	Fe-S assembly protein
A8C56_RS07205	COG0396	ATPase activity
A8C56_RS07210	COG0719	Fe-S assembly protein
A8C56_RS07225	COG2268	Band 7 protein
A8C56_RS07240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8C56_RS07255	COG0583	DNA-binding transcription factor activity
A8C56_RS07260	COG0277	FAD linked oxidase domain protein
A8C56_RS07265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A8C56_RS07270	COG3781	membrane
A8C56_RS07280	COG1515	deoxyribonuclease V activity
A8C56_RS07290	COG5002	protein histidine kinase activity
A8C56_RS07295	COG2205	protein histidine kinase activity
A8C56_RS07305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A8C56_RS07315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A8C56_RS07330	COG2204	response regulator
A8C56_RS07370	COG4771	TonB-dependent receptor
A8C56_RS07375	COG0702	epimerase
A8C56_RS07435	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C56_RS07460	COG2205	protein histidine kinase activity
A8C56_RS07470	COG2823	Periplasmic or secreted lipoprotein
A8C56_RS07475	COG0574	Belongs to the PEP-utilizing enzyme family
A8C56_RS07475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A8C56_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS07490	COG1809	phosphosulfolactate synthase activity
A8C56_RS07500	COG4771	TonB-dependent receptor
A8C56_RS07505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A8C56_RS07520	COG0363	glucosamine-6-phosphate deaminase activity
A8C56_RS07525	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8C56_RS07535	COG1446	asparaginase
A8C56_RS07540	COG3142	Participates in the control of copper homeostasis
A8C56_RS07560	COG0488	(ABC) transporter
A8C56_RS07580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C56_RS07590	COG2814	Major facilitator Superfamily
A8C56_RS07595	COG1538	Outer membrane efflux protein
A8C56_RS07605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS07630	COG1629	transport
A8C56_RS07635	COG2271	Major facilitator Superfamily
A8C56_RS07655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A8C56_RS07680	COG0247	lactate metabolic process
A8C56_RS07680	COG2181	nitrate reductase activity
A8C56_RS07685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A8C56_RS07690	COG0412	Dienelactone hydrolase
A8C56_RS07695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A8C56_RS07700	COG0673	inositol 2-dehydrogenase activity
A8C56_RS07740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8C56_RS07750	COG0723	plastoquinol--plastocyanin reductase activity
A8C56_RS07750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C56_RS07765	COG3685	Protein conserved in bacteria
A8C56_RS07790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A8C56_RS07800	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS07805	COG0723	plastoquinol--plastocyanin reductase activity
A8C56_RS07825	COG1914	H( )-stimulated, divalent metal cation uptake system
A8C56_RS07840	COG5002	protein histidine kinase activity
A8C56_RS07845	COG0745	RESPONSE REGULATOR receiver
A8C56_RS07860	COG1858	cytochrome C peroxidase
A8C56_RS07910	COG3328	transposase activity
A8C56_RS07935	COG1876	peptidase activity
A8C56_RS07950	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS07950	COG0297	glycogen (starch) synthase activity
A8C56_RS07960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A8C56_RS07965	COG1086	Polysaccharide biosynthesis protein
A8C56_RS07970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS07995	COG1086	Polysaccharide biosynthesis protein
A8C56_RS08000	COG0463	Glycosyl transferase, family 2
A8C56_RS08000	COG1216	Glycosyl transferase, family 2
A8C56_RS08015	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS08015	COG0297	glycogen (starch) synthase activity
A8C56_RS08035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A8C56_RS08040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A8C56_RS08060	COG0825	malonyl-CoA metabolic process
A8C56_RS08065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C56_RS08070	COG2827	Endonuclease containing a URI domain
A8C56_RS08080	COG1305	Transglutaminase-like
A8C56_RS08090	COG2308	Evidence 4 Homologs of previously reported genes of
A8C56_RS08095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A8C56_RS08105	COG0740	serine-type endopeptidase activity
A8C56_RS08140	COG0784	Response regulator, receiver
A8C56_RS08140	COG2198	Histidine kinase
A8C56_RS08140	COG0643	Histidine kinase
A8C56_RS08155	COG4948	Mandelate Racemase Muconate Lactonizing
A8C56_RS08160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A8C56_RS08170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS08180	COG0038	chloride channel
A8C56_RS08190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A8C56_RS08195	COG0589	response to stress
A8C56_RS08200	COG2205	protein histidine kinase activity
A8C56_RS08200	COG3292	Two component regulator propeller
A8C56_RS08200	COG0745	RESPONSE REGULATOR receiver
A8C56_RS08205	COG1629	transport
A8C56_RS08225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS08260	COG0191	fructose-bisphosphate aldolase activity
A8C56_RS08275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A8C56_RS08305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS08370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8C56_RS08400	COG3609	addiction module antidote protein, CC2985 family
A8C56_RS08435	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A8C56_RS08440	COG2086	electron transfer activity
A8C56_RS08450	COG0037	tRNA processing
A8C56_RS08455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A8C56_RS08460	COG1295	ribonuclease BN
A8C56_RS08465	COG3511	phospholipase C
A8C56_RS08475	COG2166	iron-sulfur cluster assembly
A8C56_RS08480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A8C56_RS08485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C56_RS08490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C56_RS08520	COG0424	maF-like protein
A8C56_RS08540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A8C56_RS08590	COG0793	Belongs to the peptidase S41A family
A8C56_RS08605	COG2211	Major facilitator Superfamily
A8C56_RS08615	COG4654	Cytochrome c, class I
A8C56_RS08635	COG2814	Major facilitator Superfamily
A8C56_RS08645	COG0525	valine-tRNA ligase activity
A8C56_RS08660	COG0196	riboflavin kinase activity
A8C56_RS08670	COG4574	serine-type endopeptidase inhibitor activity
A8C56_RS08680	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A8C56_RS08685	COG0183	Belongs to the thiolase family
A8C56_RS08695	COG3876	Protein conserved in bacteria
A8C56_RS08725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A8C56_RS08730	COG1663	tetraacyldisaccharide 4'-kinase activity
A8C56_RS08735	COG0557	exoribonuclease II activity
A8C56_RS08745	COG0531	amino acid
A8C56_RS08750	COG1193	negative regulation of DNA recombination
A8C56_RS08780	COG0205	6-phosphofructokinase activity
A8C56_RS08790	COG4771	TonB-dependent receptor
A8C56_RS08810	COG3001	Fructosamine kinase
A8C56_RS08830	COG0772	Belongs to the SEDS family
A8C56_RS08855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS08890	COG1678	Uncharacterized ACR, COG1678
A8C56_RS08910	COG0640	Transcriptional regulator
A8C56_RS08940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8C56_RS08965	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A8C56_RS08970	COG2267	carboxylic ester hydrolase activity
A8C56_RS08985	COG1045	serine acetyltransferase
A8C56_RS09030	COG0484	heat shock protein binding
A8C56_RS09035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A8C56_RS09050	COG0431	NADPH-dependent FMN reductase
A8C56_RS09070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A8C56_RS09080	COG0497	DNA recombination
A8C56_RS09100	COG0628	permease
A8C56_RS09105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A8C56_RS09105	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A8C56_RS09110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A8C56_RS09120	COG0612	Peptidase, M16
A8C56_RS09130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8C56_RS09140	COG1183	phosphatidylcholine synthase activity
A8C56_RS09150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A8C56_RS09160	COG0443	Heat shock 70 kDa protein
A8C56_RS09170	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A8C56_RS09175	COG2169	Transcriptional regulator
A8C56_RS09205	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS09210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A8C56_RS09250	COG3264	Mechanosensitive ion channel
A8C56_RS09250	COG1196	nuclear chromosome segregation
A8C56_RS09265	COG1113	amino acid transport
A8C56_RS09275	COG0312	modulator of DNA gyrase
A8C56_RS09290	COG1132	(ABC) transporter
A8C56_RS09315	COG0488	(ABC) transporter
A8C56_RS09325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8C56_RS09330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A8C56_RS09340	COG1862	Preprotein translocase
A8C56_RS09345	COG0237	dephospho-CoA kinase activity
A8C56_RS09365	COG0673	inositol 2-dehydrogenase activity
A8C56_RS09370	COG1012	belongs to the aldehyde dehydrogenase family
A8C56_RS09380	COG0681	Belongs to the peptidase S26 family
A8C56_RS09395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C56_RS09450	COG0668	transmembrane transport
A8C56_RS09500	COG3328	transposase activity
A8C56_RS09565	COG0358	DNA primase activity
A8C56_RS09650	COG3408	Glycogen debranching enzyme
A8C56_RS09670	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS09700	COG0702	epimerase
A8C56_RS09705	COG4771	TonB-dependent receptor
A8C56_RS09715	COG4771	TonB-dependent receptor
A8C56_RS09720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A8C56_RS09725	COG2207	Transcriptional regulator
A8C56_RS09725	COG0662	Cupin 2, conserved barrel domain protein
A8C56_RS09735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A8C56_RS09770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A8C56_RS09775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A8C56_RS09785	COG0297	glycogen (starch) synthase activity
A8C56_RS09790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A8C56_RS09795	COG1765	OsmC-like protein
A8C56_RS09825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A8C56_RS09835	COG2706	6-phosphogluconolactonase activity
A8C56_RS09845	COG1739	Uncharacterized protein family UPF0029
A8C56_RS09850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C56_RS09850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A8C56_RS09855	COG2890	protein-(glutamine-N5) methyltransferase activity
A8C56_RS09865	COG2195	Cleaves the N-terminal amino acid of tripeptides
A8C56_RS09870	COG1047	Peptidyl-prolyl cis-trans
A8C56_RS09875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8C56_RS09885	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A8C56_RS09905	COG2814	Major facilitator Superfamily
A8C56_RS09920	COG0018	arginyl-trna synthetase
A8C56_RS09940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C56_RS09945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A8C56_RS09955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C56_RS09970	COG1090	epimerase
A8C56_RS09975	COG1959	2 iron, 2 sulfur cluster binding
A8C56_RS09995	COG0431	NADPH-dependent FMN reductase
A8C56_RS10000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A8C56_RS10005	COG2814	Major facilitator Superfamily
A8C56_RS10015	COG0859	PFAM glycosyl transferase family 9
A8C56_RS10020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8C56_RS10020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8C56_RS10040	COG1473	amidohydrolase
A8C56_RS10135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C56_RS10140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C56_RS10160	COG2197	response regulator
A8C56_RS10175	COG3254	rhamnose metabolic process
A8C56_RS10200	COG4651	solute:proton antiporter activity
A8C56_RS10200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A8C56_RS10230	COG3011	Protein conserved in bacteria
A8C56_RS10245	COG2259	Doxx family
A8C56_RS10260	COG1640	4-alpha-glucanotransferase
A8C56_RS10270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A8C56_RS10280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A8C56_RS10285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A8C56_RS10300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A8C56_RS10345	COG3278	Belongs to the heme-copper respiratory oxidase family
A8C56_RS10370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A8C56_RS10375	COG0662	Cupin 2, conserved barrel domain protein
A8C56_RS10390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A8C56_RS10395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8C56_RS10400	COG1477	protein flavinylation
A8C56_RS10435	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A8C56_RS10445	COG0247	lactate metabolic process
A8C56_RS10455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A8C56_RS10465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A8C56_RS10475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A8C56_RS10515	COG1131	(ABC) transporter
A8C56_RS10525	COG0601	transmembrane transport
A8C56_RS10540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A8C56_RS10545	COG3118	belongs to the thioredoxin family
A8C56_RS10550	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C56_RS10555	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C56_RS10565	COG0105	UTP biosynthetic process
A8C56_RS10570	COG1054	Belongs to the UPF0176 family
A8C56_RS10600	COG0456	acetyltransferase
A8C56_RS10610	COG0247	lactate metabolic process
A8C56_RS10610	COG2181	nitrate reductase activity
A8C56_RS10625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A8C56_RS10630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A8C56_RS10635	COG0492	ferredoxin-NADP+ reductase activity
A8C56_RS10645	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C56_RS10645	COG0022	dehydrogenase e1 component
A8C56_RS10655	COG0477	Major facilitator Superfamily
A8C56_RS10660	COG3250	beta-galactosidase activity
A8C56_RS10665	COG0494	nUDIX hydrolase
A8C56_RS10670	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C56_RS10675	COG1131	(ABC) transporter
A8C56_RS10680	COG0527	aspartate kinase activity
A8C56_RS10695	COG0166	Belongs to the GPI family
A8C56_RS10705	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A8C56_RS10710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A8C56_RS10735	COG4771	TonB-dependent receptor
A8C56_RS10750	COG0857	belongs to the CobB CobQ family
A8C56_RS10750	COG0280	phosphate acetyltransferase
A8C56_RS10760	COG3119	arylsulfatase activity
A8C56_RS10770	COG0295	cytidine deaminase activity
A8C56_RS10785	COG0492	ferredoxin-NADP+ reductase activity
A8C56_RS10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C56_RS10810	COG2183	response to ionizing radiation
A8C56_RS10830	COG2217	Heavy metal translocating P-type atpase
A8C56_RS10835	COG0670	Belongs to the BI1 family
A8C56_RS10845	COG0515	serine threonine protein kinase
A8C56_RS10845	COG2815	serine threonine protein kinase
A8C56_RS10865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C56_RS10870	COG3537	Alpha-1,2-mannosidase
A8C56_RS10880	COG2814	Major facilitator Superfamily
A8C56_RS10885	COG3537	Alpha-1,2-mannosidase
A8C56_RS10905	COG0702	epimerase
A8C56_RS10910	COG4771	TonB-dependent receptor
A8C56_RS10915	COG2188	Transcriptional regulator
A8C56_RS10920	COG3119	arylsulfatase activity
A8C56_RS10930	COG4771	TonB-dependent receptor
A8C56_RS10935	COG0702	epimerase
A8C56_RS10960	COG1629	transport
A8C56_RS10960	COG4206	TonB-dependent receptor
A8C56_RS10980	COG1090	epimerase
A8C56_RS10990	COG2855	membrane
A8C56_RS10995	COG5002	protein histidine kinase activity
A8C56_RS11000	COG0745	RESPONSE REGULATOR receiver
A8C56_RS11015	COG0673	inositol 2-dehydrogenase activity
A8C56_RS11070	COG0529	Catalyzes the synthesis of activated sulfate
A8C56_RS11090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A8C56_RS11110	COG1136	(ABC) transporter
A8C56_RS11110	COG0577	efflux transmembrane transporter activity
A8C56_RS11115	COG0577	efflux transmembrane transporter activity
A8C56_RS11120	COG1136	(ABC) transporter
A8C56_RS11120	COG0577	efflux transmembrane transporter activity
A8C56_RS11125	COG0577	efflux transmembrane transporter activity
A8C56_RS11135	COG0577	efflux transmembrane transporter activity
A8C56_RS11150	COG0577	efflux transmembrane transporter activity
A8C56_RS11165	COG0577	efflux transmembrane transporter activity
A8C56_RS11170	COG0577	efflux transmembrane transporter activity
A8C56_RS11175	COG0577	efflux transmembrane transporter activity
A8C56_RS11180	COG0577	efflux transmembrane transporter activity
A8C56_RS11185	COG0577	efflux transmembrane transporter activity
A8C56_RS11190	COG1136	(ABC) transporter
A8C56_RS11220	COG3852	Histidine kinase
A8C56_RS11235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A8C56_RS11235	COG0392	lysyltransferase activity
A8C56_RS11250	COG0784	Response regulator, receiver
A8C56_RS11250	COG2205	protein histidine kinase activity
A8C56_RS11260	COG3279	Response regulator of the LytR AlgR family
A8C56_RS11275	COG1472	Belongs to the glycosyl hydrolase 3 family
A8C56_RS11285	COG2211	Major facilitator Superfamily
A8C56_RS11300	COG3661	Belongs to the glycosyl hydrolase 67 family
A8C56_RS11310	COG4771	TonB-dependent receptor
A8C56_RS11315	COG0702	epimerase
A8C56_RS11320	COG3250	beta-galactosidase activity
A8C56_RS11330	COG1070	Carbohydrate kinase
A8C56_RS11400	COG0343	queuine tRNA-ribosyltransferase activity
A8C56_RS11415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS11445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8C56_RS11450	COG3119	arylsulfatase activity
A8C56_RS11470	COG0714	Associated with various cellular activities
A8C56_RS11475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C56_RS11475	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A8C56_RS11500	COG0473	3-isopropylmalate dehydrogenase activity
A8C56_RS11505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A8C56_RS11515	COG0475	glutathione-regulated potassium exporter activity
A8C56_RS11515	COG0589	response to stress
A8C56_RS11555	COG2160	L-arabinose isomerase activity
A8C56_RS11565	COG1069	ribulokinase activity
A8C56_RS11570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A8C56_RS11575	COG3507	Belongs to the glycosyl hydrolase 43 family
A8C56_RS11580	COG1607	acyl-coa hydrolase
A8C56_RS11585	COG4232	protein-disulfide reductase activity
A8C56_RS11605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8C56_RS11605	COG1519	Transferase
A8C56_RS11615	COG1435	thymidine kinase activity
A8C56_RS11635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C56_RS11650	COG0416	fatty acid biosynthetic process
A8C56_RS11660	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A8C56_RS11685	COG0179	Fumarylacetoacetate (FAA) hydrolase
A8C56_RS11690	COG0193	aminoacyl-tRNA hydrolase activity
A8C56_RS11695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A8C56_RS11700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A8C56_RS11705	COG2003	Belongs to the UPF0758 family
A8C56_RS11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
A8C56_RS11740	COG3511	phospholipase C
A8C56_RS11745	COG1185	polyribonucleotide nucleotidyltransferase activity
A8C56_RS11770	COG3015	lipoprotein NlpE involved in copper resistance
A8C56_RS11820	COG3345	alpha-galactosidase
A8C56_RS11825	COG1960	acyl-CoA dehydrogenase activity
A8C56_RS11835	COG0552	protein localization to endoplasmic reticulum
A8C56_RS11840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A8C56_RS11845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A8C56_RS11855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A8C56_RS11860	COG0789	Transcriptional regulator
A8C56_RS11870	COG0481	GTPase activity
A8C56_RS11905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A8C56_RS11905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A8C56_RS11910	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A8C56_RS11915	COG0745	RESPONSE REGULATOR receiver
A8C56_RS11915	COG2205	protein histidine kinase activity
A8C56_RS11915	COG3292	Two component regulator propeller
A8C56_RS11920	COG3250	beta-galactosidase activity
A8C56_RS11930	COG1629	transport
A8C56_RS11940	COG2382	esterase
A8C56_RS11980	COG0420	3'-5' exonuclease activity
A8C56_RS11985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS12010	COG3279	Response regulator of the LytR AlgR family
A8C56_RS12030	COG2095	MarC family integral membrane protein
A8C56_RS12060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A8C56_RS12070	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A8C56_RS12075	COG1418	mRNA catabolic process
A8C56_RS12080	COG2814	Major facilitator Superfamily
A8C56_RS12085	COG0335	large ribosomal subunit rRNA binding
A8C56_RS12105	COG4771	TonB-dependent receptor
A8C56_RS12110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A8C56_RS12115	COG0154	amidase activity
A8C56_RS12120	COG0741	lytic transglycosylase activity
A8C56_RS12120	COG1388	LysM domain
A8C56_RS12130	COG1131	(ABC) transporter
A8C56_RS12160	COG4771	TonB-dependent receptor
A8C56_RS12175	COG4771	TonB-dependent receptor
A8C56_RS12210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A8C56_RS12220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A8C56_RS12225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A8C56_RS12235	COG0544	peptidyl-prolyl cis-trans isomerase activity
A8C56_RS12240	COG1621	beta-fructofuranosidase activity
A8C56_RS12260	COG0039	L-malate dehydrogenase activity
A8C56_RS12275	COG0556	nucleotide-excision repair
A8C56_RS12310	COG0358	DNA primase activity
A8C56_RS12395	COG4993	Dehydrogenase
A8C56_RS12415	COG2814	Major facilitator Superfamily
A8C56_RS12420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS12445	COG4771	TonB-dependent receptor
A8C56_RS12460	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A8C56_RS12600	COG3250	beta-galactosidase activity
A8C56_RS12605	COG0457	Tetratricopeptide repeat
A8C56_RS12610	COG2814	Major facilitator Superfamily
A8C56_RS12615	COG3250	beta-galactosidase activity
A8C56_RS12620	COG3119	arylsulfatase activity
A8C56_RS12640	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS12650	COG5492	domain, Protein
A8C56_RS12655	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS12680	COG4771	TonB-dependent receptor
A8C56_RS12690	COG4771	TonB-dependent receptor
A8C56_RS12725	COG4221	oxidoreductase activity
A8C56_RS12740	COG1301	dicarboxylic acid transport
A8C56_RS12755	COG0745	RESPONSE REGULATOR receiver
A8C56_RS12760	COG5002	protein histidine kinase activity
A8C56_RS12775	COG1742	UPF0060 membrane protein
A8C56_RS12815	COG4680	protein conserved in bacteria
A8C56_RS12835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8C56_RS12845	COG0463	Glycosyl transferase, family 2
A8C56_RS12870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A8C56_RS12880	COG0626	cystathionine gamma-synthase activity
A8C56_RS12885	COG0667	Aldo Keto reductase
A8C56_RS12910	COG2267	carboxylic ester hydrolase activity
A8C56_RS12935	COG3590	peptidase
A8C56_RS12950	COG3209	COG3209 Rhs family protein
A8C56_RS12970	COG0673	inositol 2-dehydrogenase activity
A8C56_RS12995	COG0456	acetyltransferase
A8C56_RS13020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A8C56_RS13035	COG0523	cobalamin synthesis protein
A8C56_RS13040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8C56_RS13055	COG1629	transport
A8C56_RS13080	COG1609	Transcriptional regulator
A8C56_RS13105	COG0702	epimerase
A8C56_RS13110	COG1629	transport
A8C56_RS13115	COG1609	Transcriptional regulator
A8C56_RS13130	COG1830	Aldolase
A8C56_RS13140	COG2211	Major facilitator Superfamily
A8C56_RS13145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8C56_RS13165	COG1914	H( )-stimulated, divalent metal cation uptake system
A8C56_RS13175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A8C56_RS13200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8C56_RS13205	COG3795	YCII-related domain
A8C56_RS13210	COG4941	Belongs to the sigma-70 factor family
A8C56_RS13220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C56_RS13240	COG2207	Transcriptional regulator
A8C56_RS13245	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C56_RS13300	COG0629	single-stranded DNA binding
A8C56_RS13330	COG0673	inositol 2-dehydrogenase activity
A8C56_RS13355	COG0358	DNA primase activity
A8C56_RS13360	COG0519	Catalyzes the synthesis of GMP from XMP
A8C56_RS13400	COG1629	transport
A8C56_RS13400	COG4206	TonB-dependent receptor
A8C56_RS13425	COG4771	TonB-dependent receptor
A8C56_RS13455	COG4771	TonB-dependent receptor
A8C56_RS13470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8C56_RS13475	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS13510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A8C56_RS13520	COG4771	TonB-dependent receptor
A8C56_RS13535	COG1629	transport
A8C56_RS13540	COG1609	Transcriptional regulator
A8C56_RS13545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A8C56_RS13560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A8C56_RS13565	COG0460	homoserine dehydrogenase
A8C56_RS13570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A8C56_RS13575	COG1136	(ABC) transporter
A8C56_RS13575	COG0577	efflux transmembrane transporter activity
A8C56_RS13595	COG0300	oxidoreductase activity
A8C56_RS13605	COG2365	Tyrosine phosphatase family
A8C56_RS13610	COG0028	Belongs to the TPP enzyme family
A8C56_RS13620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C56_RS13685	COG3852	Histidine kinase
A8C56_RS13690	COG2192	nodulation
A8C56_RS13695	COG1216	Glycosyl transferase, family 2
A8C56_RS13700	COG0859	PFAM glycosyl transferase family 9
A8C56_RS13705	COG0859	PFAM glycosyl transferase family 9
A8C56_RS13710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A8C56_RS13710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A8C56_RS13720	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS13745	COG3685	Protein conserved in bacteria
A8C56_RS13755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C56_RS13755	COG0189	ligase activity
A8C56_RS13805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A8C56_RS13820	COG1966	Carbon starvation protein
A8C56_RS13825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A8C56_RS13840	COG0561	phosphatase activity
A8C56_RS13845	COG4771	TonB-dependent receptor
A8C56_RS13860	COG0129	dihydroxy-acid dehydratase activity
A8C56_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS13885	COG3258	Cytochrome c
A8C56_RS13890	COG2326	polyphosphate kinase activity
A8C56_RS13915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS13920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A8C56_RS13925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8C56_RS13935	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C56_RS13955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A8C56_RS13965	COG1216	Glycosyl transferase, family 2
A8C56_RS13970	COG1193	negative regulation of DNA recombination
A8C56_RS13980	COG0010	Belongs to the arginase family
A8C56_RS14000	COG3228	Belongs to the MtfA family
A8C56_RS14015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A8C56_RS14020	COG2264	protein methyltransferase activity
A8C56_RS14025	COG0531	amino acid
A8C56_RS14040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A8C56_RS14045	COG1012	belongs to the aldehyde dehydrogenase family
A8C56_RS14050	COG2733	membrane
A8C56_RS14060	COG0656	L-ascorbic acid biosynthetic process
A8C56_RS14115	COG2132	Multicopper oxidase
A8C56_RS14135	COG1476	TRANSCRIPTIONal
A8C56_RS14185	COG2197	response regulator
A8C56_RS14220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8C56_RS14245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A8C56_RS14250	COG0066	3-isopropylmalate dehydratase activity
A8C56_RS14295	COG2197	response regulator
A8C56_RS14300	COG0791	NLP P60 protein
A8C56_RS14320	COG2353	YceI-like domain
A8C56_RS14325	COG2076	Multidrug Resistance protein
A8C56_RS14330	COG0539	negative regulation of cytoplasmic translation
A8C56_RS14380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A8C56_RS14385	COG0167	dihydroorotate dehydrogenase activity
A8C56_RS14390	COG0861	Integral membrane protein TerC family
A8C56_RS14430	COG2824	Alkylphosphonate utilization operon protein PhnA
A8C56_RS14445	COG2198	Histidine kinase
A8C56_RS14445	COG0784	Response regulator, receiver
A8C56_RS14445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A8C56_RS14445	COG2205	protein histidine kinase activity
A8C56_RS14450	COG3132	Protein of unknown function, DUF480
A8C56_RS14455	COG1959	2 iron, 2 sulfur cluster binding
A8C56_RS14460	COG3278	Belongs to the heme-copper respiratory oxidase family
A8C56_RS14465	COG2010	Cytochrome c
A8C56_RS14490	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A8C56_RS14525	COG4952	isomerase
A8C56_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS14530	COG3347	Dehydrogenase
A8C56_RS14575	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS14580	COG1215	transferase activity, transferring glycosyl groups
A8C56_RS14620	COG4682	membrane
A8C56_RS14625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A8C56_RS14635	COG2814	Major facilitator Superfamily
A8C56_RS14640	COG2207	Transcriptional regulator
A8C56_RS14665	COG2197	response regulator
A8C56_RS14670	COG4585	Histidine kinase
A8C56_RS14730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A8C56_RS14740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A8C56_RS14745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A8C56_RS14755	COG1796	DNA polymerase
A8C56_RS14755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A8C56_RS14760	COG4191	Histidine kinase
A8C56_RS14765	COG3956	TIGRFAM MazG family protein
A8C56_RS14770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A8C56_RS14795	COG1704	LemA family
A8C56_RS14800	COG1704	LemA family
A8C56_RS14820	COG0126	phosphoglycerate kinase activity
A8C56_RS14840	COG3275	phosphorelay sensor kinase activity
A8C56_RS14845	COG3279	Response regulator of the LytR AlgR family
A8C56_RS14890	COG4948	Mandelate Racemase Muconate Lactonizing
A8C56_RS14900	COG5487	UPF0391 membrane protein
A8C56_RS14930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A8C56_RS14940	COG4774	siderophore transport
A8C56_RS14995	COG2169	Transcriptional regulator
A8C56_RS15015	COG0673	inositol 2-dehydrogenase activity
A8C56_RS15020	COG3250	beta-galactosidase activity
A8C56_RS15025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8C56_RS15040	COG0076	glutamate decarboxylase activity
A8C56_RS15055	COG2755	lipolytic protein G-D-S-L family
A8C56_RS15055	COG0657	acetylesterase activity
A8C56_RS15075	COG0463	Glycosyl transferase, family 2
A8C56_RS15085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A8C56_RS15090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A8C56_RS15095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A8C56_RS15100	COG0131	Imidazoleglycerol-phosphate dehydratase
A8C56_RS15105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A8C56_RS15115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A8C56_RS15120	COG0107	imidazoleglycerol-phosphate synthase activity
A8C56_RS15125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A8C56_RS15125	COG0140	phosphoribosyl-ATP diphosphatase activity
A8C56_RS15165	COG0545	Peptidyl-prolyl cis-trans isomerase
A8C56_RS15175	COG1522	sequence-specific DNA binding
A8C56_RS15180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A8C56_RS15195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A8C56_RS15200	COG2153	protein acetylation
A8C56_RS15205	COG4206	TonB-dependent receptor
A8C56_RS15205	COG1629	transport
A8C56_RS15225	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A8C56_RS15245	COG0049	tRNA binding
A8C56_RS15265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A8C56_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
A8C56_RS15325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A8C56_RS15330	COG1271	oxidase subunit
A8C56_RS15345	COG2814	Major facilitator Superfamily
A8C56_RS15360	COG1309	transcriptional regulator
A8C56_RS15370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A8C56_RS15375	COG0004	ammonium transporteR
A8C56_RS15380	COG0436	Aminotransferase
A8C56_RS15420	COG0792	nuclease activity
A8C56_RS15430	COG4974	Belongs to the 'phage' integrase family
A8C56_RS15460	COG0612	Peptidase, M16
A8C56_RS15470	COG0019	diaminopimelate decarboxylase activity
A8C56_RS15480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A8C56_RS15520	COG1629	transport
A8C56_RS15520	COG4206	TonB-dependent receptor
A8C56_RS15530	COG4771	TonB-dependent receptor
A8C56_RS15535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A8C56_RS15540	COG0602	queuosine metabolic process
A8C56_RS15545	COG1363	Peptidase, m42
A8C56_RS15555	COG4771	TonB-dependent receptor
A8C56_RS15565	COG4771	TonB-dependent receptor
A8C56_RS15575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A8C56_RS15590	COG3015	lipoprotein NlpE involved in copper resistance
A8C56_RS15610	COG1714	RDD family
A8C56_RS15635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8C56_RS15640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A8C56_RS15665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A8C56_RS15725	COG0702	epimerase
A8C56_RS15730	COG1629	transport
A8C56_RS15750	COG4804	nuclease activity
A8C56_RS15765	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS15780	COG1501	Belongs to the glycosyl hydrolase 31 family
A8C56_RS15790	COG3250	beta-galactosidase activity
A8C56_RS15800	COG0702	epimerase
A8C56_RS15805	COG4771	TonB-dependent receptor
A8C56_RS15810	COG0662	Cupin 2, conserved barrel domain protein
A8C56_RS15810	COG2207	Transcriptional regulator
A8C56_RS15825	COG0702	epimerase
A8C56_RS15830	COG1629	transport
A8C56_RS15845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A8C56_RS15855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A8C56_RS15865	COG1136	(ABC) transporter
A8C56_RS15880	COG1136	(ABC) transporter
A8C56_RS15885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8C56_RS15890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A8C56_RS15895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A8C56_RS15900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A8C56_RS15905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A8C56_RS15920	COG0137	argininosuccinate synthase activity
A8C56_RS15930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A8C56_RS15955	COG0667	Aldo Keto reductase
A8C56_RS15985	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A8C56_RS15990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A8C56_RS16005	COG0640	Transcriptional regulator
A8C56_RS16020	COG0531	amino acid
A8C56_RS16035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A8C56_RS16070	COG2226	methyltransferase
A8C56_RS16080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A8C56_RS16085	COG0085	RNA polymerase activity
A8C56_RS16095	COG4942	peptidase
A8C56_RS16110	COG0222	ribosome binding
A8C56_RS16115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A8C56_RS16120	COG0081	regulation of translation
A8C56_RS16125	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A8C56_RS16130	COG1132	(ABC) transporter
A8C56_RS16150	COG3754	Rhamnan synthesis protein F
A8C56_RS16155	COG1216	Glycosyl transferase, family 2
A8C56_RS16175	COG1104	cysteine desulfurase activity
A8C56_RS16185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A8C56_RS16195	COG1132	(ABC) transporter
A8C56_RS16200	COG0606	chelatase, subunit chli
A8C56_RS16230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A8C56_RS16235	COG0511	ligase activity, forming carbon-carbon bonds
A8C56_RS16240	COG0439	Biotin carboxylase
A8C56_RS16255	COG0604	alcohol dehydrogenase
A8C56_RS16260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A8C56_RS16270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A8C56_RS16275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8C56_RS16280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8C56_RS16285	COG0772	Belongs to the SEDS family
A8C56_RS16290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A8C56_RS16295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A8C56_RS16300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A8C56_RS16305	COG0768	penicillin binding
A8C56_RS16315	COG0275	rRNA processing
A8C56_RS16320	COG2001	Belongs to the MraZ family
A8C56_RS16325	COG1301	dicarboxylic acid transport
A8C56_RS16330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8C56_RS16340	COG0456	acetyltransferase
A8C56_RS16355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A8C56_RS16365	COG0025	NhaP-type Na H and K H
A8C56_RS16380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A8C56_RS16395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A8C56_RS16400	COG1595	DNA-templated transcription, initiation
A8C56_RS16405	COG1629	transport
A8C56_RS16415	COG0673	inositol 2-dehydrogenase activity
A8C56_RS16435	COG1335	isochorismatase
A8C56_RS16440	COG0148	phosphopyruvate hydratase activity
A8C56_RS16455	COG1024	Enoyl-CoA hydratase
A8C56_RS16455	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C56_RS16460	COG1131	(ABC) transporter
A8C56_RS16495	COG0811	peptide transport
A8C56_RS16500	COG0577	efflux transmembrane transporter activity
A8C56_RS16505	COG1007	ATP synthesis coupled electron transport
A8C56_RS16510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C56_RS16515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A8C56_RS16520	COG0713	ATP synthesis coupled electron transport
A8C56_RS16525	COG0839	Belongs to the complex I subunit 6 family
A8C56_RS16530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C56_RS16535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A8C56_RS16540	COG1034	ATP synthesis coupled electron transport
A8C56_RS16560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A8C56_RS16565	COG0649	NAD binding
A8C56_RS16570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C56_RS16575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C56_RS16580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A8C56_RS16605	COG0084	hydrolase, TatD family'
A8C56_RS16645	COG0542	response to heat
A8C56_RS16655	COG0791	NLP P60 protein
A8C56_RS16710	COG1490	D-aminoacyl-tRNA deacylase activity
A8C56_RS16715	COG1694	Mazg nucleotide pyrophosphohydrolase
A8C56_RS16725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS16735	COG0277	FAD linked oxidase domain protein
A8C56_RS16740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A8C56_RS16760	COG0519	Catalyzes the synthesis of GMP from XMP
A8C56_RS16760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A8C56_RS16770	COG0242	peptide deformylase activity
A8C56_RS16780	COG0180	Tryptophanyl-tRNA synthetase
A8C56_RS16785	COG1428	Deoxynucleoside kinase
A8C56_RS16795	COG0006	proline dipeptidase activity
A8C56_RS16820	COG0326	Molecular chaperone. Has ATPase activity
A8C56_RS16835	COG1053	succinate dehydrogenase
A8C56_RS16865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A8C56_RS16875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A8C56_RS16880	COG0756	dUTP diphosphatase activity
A8C56_RS16895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A8C56_RS16910	COG4172	Belongs to the ABC transporter superfamily
A8C56_RS16935	COG1250	3-hydroxyacyl-CoA dehydrogenase
A8C56_RS16940	COG4290	ribonuclease
A8C56_RS16945	COG2732	(Barnase) inhibitor
A8C56_RS16955	COG0489	protein tyrosine kinase activity
A8C56_RS16965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A8C56_RS16975	COG1475	DNA binding
A8C56_RS16980	COG1192	Involved in chromosome partitioning
A8C56_RS16985	COG1408	metallophosphoesterase
A8C56_RS16995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A8C56_RS17015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A8C56_RS17025	COG1702	phosphate starvation-inducible protein PhoH
A8C56_RS17050	COG0791	NLP P60 protein
A8C56_RS17075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A8C56_RS17090	COG2207	Transcriptional regulator
A8C56_RS17090	COG1917	Cupin 2, conserved barrel domain protein
A8C56_RS17110	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A8C56_RS17120	COG4152	abc transporter atp-binding protein
A8C56_RS17155	COG2223	nitrite transmembrane transporter activity
A8C56_RS17220	COG4804	nuclease activity
A8C56_RS17225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8C56_RS17245	COG0577	efflux transmembrane transporter activity
A8C56_RS17350	COG0772	Belongs to the SEDS family
A8C56_RS17360	COG0328	RNA-DNA hybrid ribonuclease activity
A8C56_RS17420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8C56_RS17420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A8C56_RS17430	COG0517	IMP dehydrogenase activity
A8C56_RS17430	COG0516	GMP reductase activity
A8C56_RS17435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8C56_RS17440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8C56_RS17440	COG0758	DNA mediated transformation
A8C56_RS17445	COG1012	belongs to the aldehyde dehydrogenase family
A8C56_RS17450	COG3422	double-strand break repair
A8C56_RS17455	COG3279	Response regulator of the LytR AlgR family
A8C56_RS17460	COG3275	phosphorelay sensor kinase activity
A8C56_RS17470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A8C56_RS17495	COG0336	Belongs to the RNA methyltransferase TrmD family
A8C56_RS17500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A8C56_RS17510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A8C56_RS17535	COG5002	protein histidine kinase activity
A8C56_RS17540	COG0745	RESPONSE REGULATOR receiver
A8C56_RS17560	COG0726	polysaccharide deacetylase
A8C56_RS17570	COG0542	response to heat
A8C56_RS17580	COG1234	tRNA 3'-trailer cleavage
A8C56_RS17600	COG0523	cobalamin synthesis protein
A8C56_RS17605	COG0523	cobalamin synthesis protein
A8C56_RS17610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A8C56_RS17615	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C56_RS17620	COG0297	glycogen (starch) synthase activity
A8C56_RS17625	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A8C56_RS17635	COG3119	arylsulfatase activity
A8C56_RS17640	COG1566	PFAM secretion protein HlyD family protein
A8C56_RS17665	COG2234	aminopeptidase activity
A8C56_RS17675	COG1629	transport
A8C56_RS17680	COG3265	gluconokinase activity
A8C56_RS17700	COG3408	Glycogen debranching enzyme
A8C56_RS17710	COG0069	glutamate synthase activity
A8C56_RS17710	COG0070	glutamate synthase
A8C56_RS17710	COG0067	glutamate synthase
A8C56_RS17730	COG0142	geranyltranstransferase activity
A8C56_RS17735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A8C56_RS17735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A8C56_RS17740	COG0360	Binds together with S18 to 16S ribosomal RNA
A8C56_RS17745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A8C56_RS17750	COG0359	binds to the 23S rRNA
A8C56_RS17755	COG0724	RNA recognition motif
A8C56_RS17780	COG1309	transcriptional regulator
A8C56_RS17810	COG1022	Amp-dependent synthetase and ligase
A8C56_RS17820	COG2271	Major facilitator Superfamily
A8C56_RS17830	COG2731	YhcH YjgK YiaL family protein
A8C56_RS17845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A8C56_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS17855	COG1904	glucuronate isomerase
A8C56_RS17860	COG2721	sulfolactate sulfo-lyase activity
A8C56_RS17865	COG0246	Mannitol dehydrogenase
A8C56_RS17870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A8C56_RS17945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A8C56_RS17950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS17965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A8C56_RS17985	COG1538	Outer membrane efflux protein
A8C56_RS18015	COG0714	Associated with various cellular activities
A8C56_RS18055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A8C56_RS18060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A8C56_RS18080	COG3655	Transcriptional regulator
A8C56_RS18085	COG0151	Belongs to the GarS family
A8C56_RS18090	COG3104	oligopeptide transport
A8C56_RS18095	COG1297	OPT oligopeptide transporter protein
A8C56_RS18100	COG3622	Belongs to the hyi family
A8C56_RS18105	COG0515	serine threonine protein kinase
A8C56_RS18105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8C56_RS18110	COG0673	inositol 2-dehydrogenase activity
A8C56_RS18130	COG0210	DNA helicase
A8C56_RS18140	COG3328	transposase activity
A8C56_RS18175	COG1793	dna ligase
A8C56_RS18180	COG2814	Major facilitator Superfamily
A8C56_RS18190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A8C56_RS18195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A8C56_RS18210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS18225	COG4771	TonB-dependent receptor
A8C56_RS18230	COG0642	Histidine kinase
A8C56_RS18235	COG0745	RESPONSE REGULATOR receiver
A8C56_RS18250	COG2936	dipeptidyl-peptidase activity
A8C56_RS18275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A8C56_RS18280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A8C56_RS18295	COG1309	transcriptional regulator
A8C56_RS18320	COG3757	hydrolase, family 25
A8C56_RS18330	COG3119	arylsulfatase activity
A8C56_RS18330	COG3408	Glycogen debranching enzyme
A8C56_RS18345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A8C56_RS18355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A8C56_RS18365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A8C56_RS18370	COG4591	ABC-type transport system involved in lipoprotein release permease component
A8C56_RS18380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A8C56_RS18390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C56_RS18405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A8C56_RS18410	COG0228	four-way junction DNA binding
A8C56_RS18485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS18510	COG1629	transport
A8C56_RS18515	COG1940	carbohydrate kinase activity
A8C56_RS18530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A8C56_RS18570	COG0702	epimerase
A8C56_RS18575	COG1629	transport
A8C56_RS18580	COG1629	transport
A8C56_RS18595	COG3119	arylsulfatase activity
A8C56_RS18610	COG1733	regulation of RNA biosynthetic process
A8C56_RS18620	COG0163	prenyltransferase activity
A8C56_RS18630	COG4242	Belongs to the peptidase S51 family
A8C56_RS18635	COG1446	asparaginase
A8C56_RS18650	COG1629	transport
A8C56_RS18650	COG4206	TonB-dependent receptor
A8C56_RS18660	COG1595	DNA-templated transcription, initiation
A8C56_RS18670	COG1629	transport
A8C56_RS18680	COG2814	Major facilitator Superfamily
A8C56_RS18690	COG1501	Belongs to the glycosyl hydrolase 31 family
A8C56_RS18710	COG0673	inositol 2-dehydrogenase activity
A8C56_RS18715	COG4948	Mandelate Racemase Muconate Lactonizing
A8C56_RS18755	COG0702	epimerase
A8C56_RS18760	COG4771	TonB-dependent receptor
A8C56_RS18765	COG4771	TonB-dependent receptor
A8C56_RS18770	COG2207	Transcriptional regulator
A8C56_RS18770	COG1917	Cupin 2, conserved barrel domain protein
A8C56_RS18780	COG2079	MmgE PrpD family protein
A8C56_RS18805	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS18835	COG2207	Transcriptional regulator
A8C56_RS18840	COG3795	YCII-related domain
A8C56_RS18850	COG4941	Belongs to the sigma-70 factor family
A8C56_RS18875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A8C56_RS18900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A8C56_RS18910	COG1368	sulfuric ester hydrolase activity
A8C56_RS18920	COG3621	Patatin-like phospholipase
A8C56_RS18925	COG0346	lactoylglutathione lyase activity
A8C56_RS18930	COG0346	lactoylglutathione lyase activity
A8C56_RS18970	COG1741	Belongs to the pirin family
A8C56_RS18975	COG0604	alcohol dehydrogenase
A8C56_RS18985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A8C56_RS19010	COG1959	2 iron, 2 sulfur cluster binding
A8C56_RS19015	COG0450	alkyl hydroperoxide reductase
A8C56_RS19020	COG0175	sulfate reduction
A8C56_RS19025	COG0175	sulfate reduction
A8C56_RS19035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8C56_RS19035	COG1648	precorrin-2 dehydrogenase activity
A8C56_RS19040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A8C56_RS19050	COG1045	serine acetyltransferase
A8C56_RS19055	COG1648	precorrin-2 dehydrogenase activity
A8C56_RS19055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A8C56_RS19065	COG4771	TonB-dependent receptor
A8C56_RS19080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A8C56_RS19085	COG0402	S-adenosylhomocysteine deaminase activity
A8C56_RS19090	COG1381	Involved in DNA repair and RecF pathway recombination
A8C56_RS19100	COG4676	Protein conserved in bacteria
A8C56_RS19105	COG3590	peptidase
A8C56_RS19125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8C56_RS19130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A8C56_RS19135	COG0363	glucosamine-6-phosphate deaminase activity
A8C56_RS19165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A8C56_RS19175	COG0802	atpase or kinase
A8C56_RS19190	COG0509	glycine decarboxylation via glycine cleavage system
A8C56_RS19210	COG1217	gtp-binding protein TYPA
A8C56_RS19215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A8C56_RS19220	COG1597	lipid kinase activity
A8C56_RS19225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A8C56_RS19240	COG3119	arylsulfatase activity
A8C56_RS19245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A8C56_RS19270	COG1610	YqeY-like protein
A8C56_RS19300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A8C56_RS19310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A8C56_RS19315	COG0052	Belongs to the universal ribosomal protein uS2 family
A8C56_RS19320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A8C56_RS19325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A8C56_RS19350	COG0702	epimerase
A8C56_RS19355	COG1629	transport
A8C56_RS19425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A8C56_RS19430	COG1629	transport
A8C56_RS19430	COG4206	TonB-dependent receptor
A8C56_RS19440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A8C56_RS19455	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A8C56_RS19475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A8C56_RS19510	COG4771	TonB-dependent receptor
A8C56_RS19520	COG2271	Major facilitator Superfamily
A8C56_RS19545	COG2186	Transcriptional regulator
A8C56_RS19560	COG0071	Belongs to the small heat shock protein (HSP20) family
A8C56_RS19580	COG1612	heme a metabolic process
A8C56_RS19585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A8C56_RS19605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A8C56_RS19630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS19635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C56_RS19645	COG0644	oxidoreductase
A8C56_RS19660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS19685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C56_RS19690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS19755	COG2311	Membrane
A8C56_RS19770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A8C56_RS19775	COG0702	epimerase
A8C56_RS19780	COG1629	transport
A8C56_RS19790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A8C56_RS19800	COG1530	ribonuclease E activity
A8C56_RS19810	COG0776	regulation of translation
A8C56_RS19820	COG0629	single-stranded DNA binding
A8C56_RS19825	COG4535	Mg2 and Co2 transporter CorC
A8C56_RS19835	COG1131	(ABC) transporter
A8C56_RS19870	COG1024	Enoyl-CoA hydratase
A8C56_RS19890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A8C56_RS19925	COG3275	phosphorelay sensor kinase activity
A8C56_RS19950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A8C56_RS19960	COG0316	Belongs to the HesB IscA family
A8C56_RS19965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A8C56_RS19970	COG1252	NADH dehydrogenase
A8C56_RS19980	COG0025	NhaP-type Na H and K H
A8C56_RS20065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A8C56_RS20070	COG3250	beta-galactosidase activity
A8C56_RS20075	COG0750	zinc metalloprotease
A8C56_RS20080	COG1104	cysteine desulfurase activity
A8C56_RS20090	COG0571	ribonuclease III activity
A8C56_RS20095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS20100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C56_RS20105	COG2153	protein acetylation
A8C56_RS20120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A8C56_RS20135	COG4771	TonB-dependent receptor
A8C56_RS20145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A8C56_RS20165	COG2197	response regulator
A8C56_RS20175	COG0598	Magnesium transport protein CorA
A8C56_RS20185	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A8C56_RS20200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A8C56_RS20215	COG0644	oxidoreductase
A8C56_RS20220	COG0592	DNA-directed DNA polymerase activity
A8C56_RS20230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C56_RS20255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A8C56_RS20275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A8C56_RS20280	COG0483	inositol monophosphate 1-phosphatase activity
A8C56_RS20300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A8C56_RS20310	COG3279	Response regulator of the LytR AlgR family
A8C56_RS20315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A8C56_RS20325	COG2154	pterin-4-alpha-carbinolamine dehydratase
A8C56_RS20345	COG0673	inositol 2-dehydrogenase activity
A8C56_RS20350	COG1629	transport
A8C56_RS20360	COG3291	Pkd domain containing protein
A8C56_RS20360	COG4447	cellulose binding
A8C56_RS20360	COG5520	Belongs to the glycosyl hydrolase 30 family
A8C56_RS20370	COG1349	DNA-binding transcription factor activity
A8C56_RS20375	COG1940	carbohydrate kinase activity
A8C56_RS20405	COG4771	TonB-dependent receptor
A8C56_RS20445	COG2610	gluconate transmembrane transporter activity
A8C56_RS20455	COG2755	lipolytic protein G-D-S-L family
A8C56_RS20455	COG0657	acetylesterase activity
A8C56_RS20475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A8C56_RS20490	COG4771	TonB-dependent receptor
A8C56_RS20495	COG2186	Transcriptional regulator
A8C56_RS20530	COG3345	alpha-galactosidase
A8C56_RS20540	COG4771	TonB-dependent receptor
A8C56_RS20575	COG1629	transport
A8C56_RS20580	COG0702	epimerase
A8C56_RS20585	COG4771	TonB-dependent receptor
A8C56_RS20600	COG0702	epimerase
A8C56_RS20615	COG3250	beta-galactosidase activity
A8C56_RS20630	COG3537	Alpha-1,2-mannosidase
A8C56_RS20680	COG0657	acetylesterase activity
A8C56_RS20705	COG3119	arylsulfatase activity
A8C56_RS20730	COG0702	epimerase
A8C56_RS20740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A8C56_RS20750	COG2226	methyltransferase
A8C56_RS20765	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A8C56_RS20770	COG1518	maintenance of DNA repeat elements
A8C56_RS20775	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A8C56_RS20820	COG1396	sequence-specific DNA binding
A8C56_RS20890	COG1525	nuclease
A8C56_RS20920	COG3832	glyoxalase III activity
A8C56_RS20925	COG1917	Cupin 2, conserved barrel domain protein
A8C56_RS20925	COG2207	Transcriptional regulator
A8C56_RS20940	COG1690	Belongs to the RtcB family
A8C56_RS20980	COG3152	Membrane
A8C56_RS21050	COG0778	Nitroreductase
A8C56_RS21070	COG0445	tRNA wobble uridine modification
A8C56_RS21075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A8C56_RS21080	COG1918	ferrous iron import across plasma membrane
A8C56_RS21085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A8C56_RS21100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A8C56_RS21115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A8C56_RS21120	COG2843	Capsule synthesis protein
A8C56_RS21125	COG0017	Asparaginyl-tRNA synthetase
A8C56_RS21130	COG1649	PFAM Uncharacterised BCR, COG1649
A8C56_RS21140	COG0667	Aldo Keto reductase
A8C56_RS21205	COG1396	sequence-specific DNA binding
A8C56_RS21250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A8C56_RS21290	COG1073	alpha beta
A8C56_RS21295	COG4977	sequence-specific DNA binding
A8C56_RS21295	COG1917	Cupin 2, conserved barrel domain protein
A8C56_RS21395	COG4771	TonB-dependent receptor
A8C56_RS21405	COG3940	Belongs to the glycosyl hydrolase 43 family
A8C56_RS21415	COG0513	Belongs to the DEAD box helicase family
A8C56_RS21420	COG0724	RNA recognition motif
A8C56_RS21435	COG1309	transcriptional regulator
A8C56_RS21445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS21450	COG1131	(ABC) transporter
A8C56_RS21455	COG1131	(ABC) transporter
A8C56_RS21460	COG0842	Transport permease protein
A8C56_RS21465	COG1129	ABC transporter
A8C56_RS21465	COG0842	Transport permease protein
A8C56_RS21515	COG0514	ATP-dependent DNA helicase (RecQ)
A8C56_RS21520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A8C56_RS21520	COG0517	IMP dehydrogenase activity
A8C56_RS21535	COG0251	oxidation-reduction process
A8C56_RS21540	COG2315	Protein conserved in bacteria
A8C56_RS21550	COG3537	Alpha-1,2-mannosidase
A8C56_RS21565	COG1349	DNA-binding transcription factor activity
A8C56_RS21575	COG1629	transport
A8C56_RS21590	COG0584	glycerophosphoryl diester phosphodiesterase
A8C56_RS21610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A8C56_RS21615	COG0673	inositol 2-dehydrogenase activity
A8C56_RS21630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A8C56_RS21650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A8C56_RS21655	COG3591	Belongs to the peptidase S1B family
A8C56_RS21685	COG4948	Mandelate Racemase Muconate Lactonizing
A8C56_RS21695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A8C56_RS21700	COG0306	phosphate transporter
A8C56_RS21730	COG1629	transport
A8C56_RS21745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A8C56_RS21750	COG2045	Belongs to the ComB family
A8C56_RS21755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A8C56_RS21770	COG1629	transport
A8C56_RS21785	COG0673	inositol 2-dehydrogenase activity
A8C56_RS21800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A8C56_RS21825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A8C56_RS21840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A8C56_RS21850	COG3655	Transcriptional regulator
A8C56_RS21900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A8C56_RS21910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A8C56_RS21915	COG1137	ATPase activity
A8C56_RS21925	COG0300	oxidoreductase activity
A8C56_RS21945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A8C56_RS21960	COG0564	pseudouridine synthase activity
A8C56_RS21965	COG1187	pseudouridine synthase activity
A8C56_RS21980	COG1408	metallophosphoesterase
A8C56_RS21985	COG1011	Hydrolase
A8C56_RS21990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS22020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A8C56_RS22030	COG0626	cystathionine gamma-synthase activity
A8C56_RS22055	COG1506	peptidase
A8C56_RS22075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A8C56_RS22090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A8C56_RS22100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A8C56_RS22115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A8C56_RS22120	COG4636	protein conserved in cyanobacteria
A8C56_RS22130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A8C56_RS22130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A8C56_RS22140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A8C56_RS22145	COG1556	Lactate utilization protein
A8C56_RS22210	COG0495	leucyl-tRNA aminoacylation
A8C56_RS22220	COG1968	undecaprenyl-diphosphatase activity
A8C56_RS22230	COG1895	HEPN domain
A8C56_RS22235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A8C56_RS22245	COG1063	alcohol dehydrogenase
A8C56_RS22260	COG0739	heme binding
A8C56_RS22265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A8C56_RS22280	COG0626	cystathionine gamma-synthase activity
A8C56_RS22310	COG0612	Peptidase, M16
A8C56_RS22325	COG3279	Response regulator of the LytR AlgR family
A8C56_RS22330	COG3275	phosphorelay sensor kinase activity
A8C56_RS22335	COG1289	transmembrane transporter activity
A8C56_RS22355	COG0563	adenylate kinase activity
A8C56_RS22360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A8C56_RS22370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A8C56_RS22375	COG1136	(ABC) transporter
A8C56_RS22380	COG1136	(ABC) transporter
A8C56_RS22380	COG0577	efflux transmembrane transporter activity
A8C56_RS22395	COG2255	four-way junction helicase activity
A8C56_RS22415	COG0433	COG0433 Predicted ATPase
A8C56_RS22440	COG0156	8-amino-7-oxononanoate synthase activity
A8C56_RS22455	COG2353	YceI-like domain
A8C56_RS22465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A8C56_RS22470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A8C56_RS22475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A8C56_RS22480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A8C56_RS22485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A8C56_RS22510	COG0556	nucleotide-excision repair
A8C56_RS22520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8C56_RS22520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A8C56_RS22525	COG2197	response regulator
A8C56_RS22530	COG3851	Histidine kinase
A8C56_RS22575	COG0668	transmembrane transport
A8C56_RS22585	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A8C56_RS22590	COG4774	siderophore transport
A8C56_RS22630	COG4771	TonB-dependent receptor
A8C56_RS22655	COG2161	toxin-antitoxin pair type II binding
A8C56_RS22695	COG1472	Belongs to the glycosyl hydrolase 3 family
A8C56_RS22715	COG4771	TonB-dependent receptor
A8C56_RS22720	COG0702	epimerase
A8C56_RS22735	COG1064	alcohol dehydrogenase
A8C56_RS22765	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A8C56_RS22765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A8C56_RS22785	COG1028	Short-chain dehydrogenase reductase Sdr
A8C56_RS22800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A8C56_RS22805	COG1040	competence protein
A8C56_RS22810	COG0386	Belongs to the glutathione peroxidase family
A8C56_RS22815	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A8C56_RS22835	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A8C56_RS22870	COG0110	maltose O-acetyltransferase activity
A8C56_RS22900	COG1132	(ABC) transporter
A8C56_RS22905	COG1132	(ABC) transporter
A8C56_RS22915	COG4221	oxidoreductase activity
A8C56_RS22925	COG1943	Transposase
A8C56_RS22990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C56_RS22990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A8C56_RS23010	COG1774	PSP1 C-terminal conserved region
A8C56_RS23030	COG0022	dehydrogenase e1 component
A8C56_RS23075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A8C56_RS23085	COG0437	4 iron, 4 sulfur cluster binding
A8C56_RS23110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A8C56_RS23115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A8C56_RS23120	COG0109	protoheme IX farnesyltransferase activity
A8C56_RS23125	COG1845	cytochrome c oxidase, subunit III
A8C56_RS23130	COG1845	cytochrome c oxidase, subunit III
A8C56_RS23145	COG1981	membrane
A8C56_RS23155	COG2205	protein histidine kinase activity
A8C56_RS23155	COG0784	Response regulator, receiver
A8C56_RS23170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A8C56_RS23180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A8C56_RS23185	COG0181	hydroxymethylbilane synthase activity
A8C56_RS23195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A8C56_RS23215	COG0113	porphobilinogen synthase activity
A8C56_RS23235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A8C56_RS23250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A8C56_RS23260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A8C56_RS23280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8C56_RS23290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A8C56_RS23300	COG1011	Hydrolase
A8C56_RS23305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8C56_RS23310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A8C56_RS23315	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A8C56_RS23320	COG0356	it plays a direct role in the translocation of protons across the membrane
A8C56_RS23330	COG1132	(ABC) transporter
A8C56_RS23335	COG1940	carbohydrate kinase activity
A8C56_RS23350	COG0745	RESPONSE REGULATOR receiver
A8C56_RS23355	COG5002	protein histidine kinase activity
A8C56_RS23360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A8C56_RS23365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A8C56_RS23370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A8C56_RS23385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A8C56_RS23395	COG2267	carboxylic ester hydrolase activity
A8C56_RS23405	COG1960	acyl-CoA dehydrogenase activity
A8C56_RS23425	COG2755	lipolytic protein G-D-S-L family
A8C56_RS23435	COG0702	epimerase
A8C56_RS23440	COG4771	TonB-dependent receptor
A8C56_RS23450	COG1312	Catalyzes the dehydration of D-mannonate
A8C56_RS23455	COG0009	L-threonylcarbamoyladenylate synthase
A8C56_RS23460	COG1013	pyruvate-flavodoxin oxidoreductase activity
A8C56_RS23500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A8C56_RS23505	COG2610	gluconate transmembrane transporter activity
A8C56_RS23510	COG1929	Belongs to the glycerate kinase type-1 family
A8C56_RS23590	COG1191	sigma factor activity
A8C56_RS23600	COG4771	TonB-dependent receptor
A8C56_RS23615	COG3119	arylsulfatase activity
A8C56_RS23620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A8C56_RS23660	COG1629	transport
A8C56_RS23665	COG0702	epimerase
A8C56_RS23695	COG3119	arylsulfatase activity
A8C56_RS23700	COG3119	arylsulfatase activity
A8C56_RS23710	COG3119	arylsulfatase activity
A8C56_RS23715	COG3250	beta-galactosidase activity
A8C56_RS23720	COG3119	arylsulfatase activity
A8C56_RS23735	COG3119	arylsulfatase activity
A8C56_RS23750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A8C56_RS23760	COG1247	-acetyltransferase
A8C56_RS23770	COG0438	transferase activity, transferring glycosyl groups
A8C56_RS23780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A8C56_RS23785	COG0165	Argininosuccinate lyase
A8C56_RS23790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls