locus-tag	class	description
NIAKO_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NIAKO_RS00045	COG0724	RNA recognition motif
NIAKO_RS00070	COG3685	Protein conserved in bacteria
NIAKO_RS00105	COG3546	catalase activity
NIAKO_RS00125	COG0025	NhaP-type Na H and K H
NIAKO_RS00135	COG3239	Fatty acid desaturase
NIAKO_RS00170	COG2205	protein histidine kinase activity
NIAKO_RS00170	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS00170	COG3292	Two component regulator propeller
NIAKO_RS00180	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS00190	COG4206	TonB-dependent receptor
NIAKO_RS00190	COG1629	transport
NIAKO_RS00200	COG0024	Methionine aminopeptidase
NIAKO_RS00210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIAKO_RS00230	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS00235	COG0783	Belongs to the Dps family
NIAKO_RS00255	COG4771	TonB-dependent receptor
NIAKO_RS00275	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS00300	COG3959	Transketolase, thiamine diphosphate binding domain
NIAKO_RS00305	COG3958	Transketolase
NIAKO_RS00320	COG1129	ABC transporter
NIAKO_RS00325	COG1172	Belongs to the binding-protein-dependent transport system permease family
NIAKO_RS00330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIAKO_RS00370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NIAKO_RS00370	COG0662	Cupin 2, conserved barrel domain protein
NIAKO_RS00390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIAKO_RS00410	COG0297	glycogen (starch) synthase activity
NIAKO_RS00425	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIAKO_RS00480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIAKO_RS00485	COG0473	3-isopropylmalate dehydrogenase activity
NIAKO_RS00490	COG0129	dihydroxy-acid dehydratase activity
NIAKO_RS00495	COG0028	Belongs to the TPP enzyme family
NIAKO_RS00500	COG4106	trans-aconitate 2-methyltransferase activity
NIAKO_RS00510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NIAKO_RS00515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIAKO_RS00520	COG0067	glutamate synthase
NIAKO_RS00520	COG0070	glutamate synthase
NIAKO_RS00520	COG0069	glutamate synthase activity
NIAKO_RS00530	COG0004	ammonium transporteR
NIAKO_RS00540	COG0004	ammonium transporteR
NIAKO_RS00545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NIAKO_RS00550	COG0527	aspartate kinase activity
NIAKO_RS00550	COG0460	homoserine dehydrogenase
NIAKO_RS00555	COG0083	homoserine kinase activity
NIAKO_RS00565	COG0460	homoserine dehydrogenase
NIAKO_RS00570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NIAKO_RS00575	COG0626	cystathionine gamma-synthase activity
NIAKO_RS00590	COG3047	cAMP biosynthetic process
NIAKO_RS00590	COG2885	chlorophyll binding
NIAKO_RS00595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIAKO_RS00600	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
NIAKO_RS00620	COG2153	protein acetylation
NIAKO_RS00625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NIAKO_RS00635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NIAKO_RS00675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NIAKO_RS00680	COG1127	ABC transporter
NIAKO_RS00685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIAKO_RS00690	COG0280	phosphate acetyltransferase
NIAKO_RS00690	COG0281	malic enzyme
NIAKO_RS00720	COG1131	(ABC) transporter
NIAKO_RS00730	COG1725	Transcriptional regulator
NIAKO_RS00745	COG1473	amidohydrolase
NIAKO_RS00765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NIAKO_RS00775	COG1228	amidohydrolase
NIAKO_RS00795	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NIAKO_RS00800	COG3698	Phosphodiester glycosidase
NIAKO_RS00810	COG0653	protein targeting
NIAKO_RS00815	COG0758	DNA mediated transformation
NIAKO_RS00820	COG2885	chlorophyll binding
NIAKO_RS00820	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS00825	COG0602	queuosine metabolic process
NIAKO_RS00830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NIAKO_RS00845	COG4771	TonB-dependent receptor
NIAKO_RS00860	COG1629	transport
NIAKO_RS00860	COG4206	TonB-dependent receptor
NIAKO_RS00875	COG2003	Belongs to the UPF0758 family
NIAKO_RS00885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIAKO_RS00890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NIAKO_RS00900	COG0193	aminoacyl-tRNA hydrolase activity
NIAKO_RS00905	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIAKO_RS00910	COG0022	dehydrogenase e1 component
NIAKO_RS00930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NIAKO_RS00935	COG3119	arylsulfatase activity
NIAKO_RS00940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS00945	COG3537	Alpha-1,2-mannosidase
NIAKO_RS00950	COG1609	Transcriptional regulator
NIAKO_RS01005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS01010	COG0633	Ferredoxin
NIAKO_RS01010	COG3217	Mosc domain protein beta barrel domain protein
NIAKO_RS01050	COG4181	ATPase activity
NIAKO_RS01060	COG1252	NADH dehydrogenase
NIAKO_RS01070	COG0719	Fe-S assembly protein
NIAKO_RS01075	COG0396	ATPase activity
NIAKO_RS01080	COG0719	Fe-S assembly protein
NIAKO_RS01090	COG2166	iron-sulfur cluster assembly
NIAKO_RS01125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIAKO_RS01150	COG1595	DNA-templated transcription, initiation
NIAKO_RS01155	COG4206	TonB-dependent receptor
NIAKO_RS01155	COG1629	transport
NIAKO_RS01185	COG2207	Transcriptional regulator
NIAKO_RS01205	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS01210	COG2198	Histidine kinase
NIAKO_RS01210	COG0643	Histidine kinase
NIAKO_RS01215	COG0835	chemotaxis
NIAKO_RS01220	COG0840	transmembrane signaling receptor activity
NIAKO_RS01240	COG4771	TonB-dependent receptor
NIAKO_RS01285	COG0640	Transcriptional regulator
NIAKO_RS01290	COG4895	conserved protein (DUF2196)
NIAKO_RS01300	COG3527	Alpha-acetolactate decarboxylase
NIAKO_RS01330	COG2169	Transcriptional regulator
NIAKO_RS01335	COG3420	alginic acid biosynthetic process
NIAKO_RS01350	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS01355	COG0577	efflux transmembrane transporter activity
NIAKO_RS01355	COG1136	(ABC) transporter
NIAKO_RS01380	COG1309	transcriptional regulator
NIAKO_RS01385	COG4221	oxidoreductase activity
NIAKO_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS01415	COG3876	Protein conserved in bacteria
NIAKO_RS01420	COG0436	Aminotransferase
NIAKO_RS01435	COG0022	dehydrogenase e1 component
NIAKO_RS01450	COG3011	Protein conserved in bacteria
NIAKO_RS01460	COG0531	amino acid
NIAKO_RS01465	COG1301	dicarboxylic acid transport
NIAKO_RS01470	COG0586	Pfam SNARE associated Golgi protein
NIAKO_RS01475	COG2814	Major facilitator Superfamily
NIAKO_RS01480	COG0859	PFAM glycosyl transferase family 9
NIAKO_RS01505	COG0039	L-malate dehydrogenase activity
NIAKO_RS01525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NIAKO_RS01530	COG0511	ligase activity, forming carbon-carbon bonds
NIAKO_RS01535	COG0439	Biotin carboxylase
NIAKO_RS01545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NIAKO_RS01550	COG0366	Alpha amylase catalytic
NIAKO_RS01555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS01565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIAKO_RS01570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIAKO_RS01575	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIAKO_RS01590	COG2815	serine threonine protein kinase
NIAKO_RS01590	COG0515	serine threonine protein kinase
NIAKO_RS01615	COG2827	Endonuclease containing a URI domain
NIAKO_RS01625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIAKO_RS01630	COG1160	GTP binding
NIAKO_RS01640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIAKO_RS01645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NIAKO_RS01650	COG0823	Involved in the tonB-independent uptake of proteins
NIAKO_RS01650	COG1506	peptidase
NIAKO_RS01650	COG4946	Tricorn protease homolog
NIAKO_RS01655	COG2239	Acts as a magnesium transporter
NIAKO_RS01685	COG3781	membrane
NIAKO_RS01705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIAKO_RS01715	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS01745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NIAKO_RS01750	COG2388	GCN5-related N-acetyl-transferase
NIAKO_RS01760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIAKO_RS01770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIAKO_RS01775	COG0134	indole-3-glycerol-phosphate synthase activity
NIAKO_RS01780	COG0135	phosphoribosylanthranilate isomerase activity
NIAKO_RS01790	COG0133	tryptophan synthase activity
NIAKO_RS01795	COG0159	tryptophan synthase activity
NIAKO_RS01800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIAKO_RS01805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NIAKO_RS01810	COG0107	imidazoleglycerol-phosphate synthase activity
NIAKO_RS01820	COG0140	phosphoribosyl-ATP diphosphatase activity
NIAKO_RS01820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIAKO_RS01825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS01835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NIAKO_RS01865	COG0456	acetyltransferase
NIAKO_RS01875	COG0045	succinate-CoA ligase (ADP-forming) activity
NIAKO_RS01925	COG0531	amino acid
NIAKO_RS01930	COG4303	Ethanolamine ammonia lyase large subunit
NIAKO_RS01935	COG4302	ethanolamine ammonia-lyase activity
NIAKO_RS01945	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NIAKO_RS01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIAKO_RS01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIAKO_RS01995	COG0405	Gamma-glutamyltransferase
NIAKO_RS02045	COG4974	Belongs to the 'phage' integrase family
NIAKO_RS02055	COG0792	nuclease activity
NIAKO_RS02060	COG1482	cell wall glycoprotein biosynthetic process
NIAKO_RS02070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS02075	COG0328	RNA-DNA hybrid ribonuclease activity
NIAKO_RS02080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NIAKO_RS02085	COG4122	O-methyltransferase activity
NIAKO_RS02120	COG4771	TonB-dependent receptor
NIAKO_RS02155	COG3257	ureidoglycine aminohydrolase activity
NIAKO_RS02165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIAKO_RS02180	COG0829	nickel cation binding
NIAKO_RS02185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIAKO_RS02190	COG0830	nickel cation binding
NIAKO_RS02195	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NIAKO_RS02200	COG0804	urea catabolic process
NIAKO_RS02205	COG0832	Belongs to the urease beta subunit family
NIAKO_RS02210	COG0831	urea catabolic process
NIAKO_RS02215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NIAKO_RS02215	COG3608	succinylglutamate desuccinylase aspartoacylase
NIAKO_RS02220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIAKO_RS02230	COG1522	sequence-specific DNA binding
NIAKO_RS02235	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS02240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NIAKO_RS02245	COG1953	Uracil, thiamine, allantoin
NIAKO_RS02260	COG0493	'glutamate synthase
NIAKO_RS02380	COG2197	response regulator
NIAKO_RS02440	COG2239	Acts as a magnesium transporter
NIAKO_RS02455	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS02455	COG4977	sequence-specific DNA binding
NIAKO_RS02525	COG4191	Histidine kinase
NIAKO_RS02530	COG1216	Glycosyl transferase, family 2
NIAKO_RS02590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIAKO_RS02595	COG2188	Transcriptional regulator
NIAKO_RS02610	COG1482	cell wall glycoprotein biosynthetic process
NIAKO_RS02615	COG3537	Alpha-1,2-mannosidase
NIAKO_RS02620	COG2814	Major facilitator Superfamily
NIAKO_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS02655	COG1629	transport
NIAKO_RS02655	COG4206	TonB-dependent receptor
NIAKO_RS02690	COG2010	Cytochrome c
NIAKO_RS02690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIAKO_RS02700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NIAKO_RS02705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIAKO_RS02710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIAKO_RS02715	COG0303	'Molybdopterin
NIAKO_RS02730	COG0315	cyclic pyranopterin monophosphate synthase activity
NIAKO_RS02730	COG0521	Mo-molybdopterin cofactor biosynthetic process
NIAKO_RS02750	COG2186	Transcriptional regulator
NIAKO_RS02755	COG1629	transport
NIAKO_RS02765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS02775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS02780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIAKO_RS02800	COG3956	TIGRFAM MazG family protein
NIAKO_RS02810	COG1796	DNA polymerase
NIAKO_RS02810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NIAKO_RS02820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NIAKO_RS02830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NIAKO_RS02835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NIAKO_RS02845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NIAKO_RS02850	COG0750	zinc metalloprotease
NIAKO_RS02870	COG0577	efflux transmembrane transporter activity
NIAKO_RS02910	COG0667	Aldo Keto reductase
NIAKO_RS02925	COG1902	pentaerythritol trinitrate reductase activity
NIAKO_RS02955	COG0657	acetylesterase activity
NIAKO_RS02960	COG1741	Belongs to the pirin family
NIAKO_RS02990	COG0604	alcohol dehydrogenase
NIAKO_RS03030	COG2972	Histidine kinase
NIAKO_RS03030	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS03035	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS03110	COG3420	alginic acid biosynthetic process
NIAKO_RS03130	COG3275	phosphorelay sensor kinase activity
NIAKO_RS03135	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS03150	COG0346	lactoylglutathione lyase activity
NIAKO_RS03190	COG3152	Membrane
NIAKO_RS03200	COG0642	Histidine kinase
NIAKO_RS03205	COG2197	response regulator
NIAKO_RS03220	COG3158	transport of potassium into the cell
NIAKO_RS03230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIAKO_RS03290	COG0456	acetyltransferase
NIAKO_RS03290	COG1846	Transcriptional regulator
NIAKO_RS03330	COG1696	Membrane protein involved in D-alanine export
NIAKO_RS03365	COG4585	Histidine kinase
NIAKO_RS03380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIAKO_RS03395	COG0667	Aldo Keto reductase
NIAKO_RS03415	COG1649	PFAM Uncharacterised BCR, COG1649
NIAKO_RS03425	COG0366	Alpha amylase catalytic
NIAKO_RS03435	COG1881	PFAM PEBP family protein
NIAKO_RS03450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NIAKO_RS03475	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS03490	COG1349	DNA-binding transcription factor activity
NIAKO_RS03510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NIAKO_RS03515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIAKO_RS03520	COG0584	glycerophosphoryl diester phosphodiesterase
NIAKO_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS03540	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NIAKO_RS03550	COG3507	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS03565	COG1629	transport
NIAKO_RS03565	COG4206	TonB-dependent receptor
NIAKO_RS03580	COG0702	epimerase
NIAKO_RS03585	COG1629	transport
NIAKO_RS03600	COG4771	TonB-dependent receptor
NIAKO_RS03615	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS03660	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS03665	COG3661	Belongs to the glycosyl hydrolase 67 family
NIAKO_RS03670	COG1609	Transcriptional regulator
NIAKO_RS03680	COG1312	Catalyzes the dehydration of D-mannonate
NIAKO_RS03685	COG1368	sulfuric ester hydrolase activity
NIAKO_RS03690	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS03695	COG0642	Histidine kinase
NIAKO_RS03700	COG4771	TonB-dependent receptor
NIAKO_RS03705	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS03720	COG3401	FG-GAP repeat protein
NIAKO_RS03730	COG2252	PERMEase
NIAKO_RS03740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS03745	COG4206	TonB-dependent receptor
NIAKO_RS03745	COG1629	transport
NIAKO_RS03785	COG0577	efflux transmembrane transporter activity
NIAKO_RS03785	COG1136	(ABC) transporter
NIAKO_RS03790	COG2223	nitrite transmembrane transporter activity
NIAKO_RS03805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIAKO_RS03825	COG0346	lactoylglutathione lyase activity
NIAKO_RS03830	COG2353	YceI-like domain
NIAKO_RS03835	COG2353	YceI-like domain
NIAKO_RS03845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIAKO_RS03845	COG1321	iron dependent repressor
NIAKO_RS03900	COG3876	Protein conserved in bacteria
NIAKO_RS03935	COG0612	Peptidase, M16
NIAKO_RS03970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NIAKO_RS03970	COG0392	lysyltransferase activity
NIAKO_RS03975	COG0577	efflux transmembrane transporter activity
NIAKO_RS03990	COG1629	transport
NIAKO_RS03995	COG0702	epimerase
NIAKO_RS04035	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS04050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NIAKO_RS04060	COG1629	transport
NIAKO_RS04115	COG0730	response to heat
NIAKO_RS04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIAKO_RS04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS04215	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS04220	COG0778	Nitroreductase
NIAKO_RS04230	COG4221	oxidoreductase activity
NIAKO_RS04240	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIAKO_RS04300	COG0300	oxidoreductase activity
NIAKO_RS04305	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS04305	COG4977	sequence-specific DNA binding
NIAKO_RS04320	COG1119	ATPase activity
NIAKO_RS04350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NIAKO_RS04355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NIAKO_RS04365	COG1053	succinate dehydrogenase
NIAKO_RS04370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NIAKO_RS04380	COG0488	(ABC) transporter
NIAKO_RS04405	COG0196	riboflavin kinase activity
NIAKO_RS04415	COG1349	DNA-binding transcription factor activity
NIAKO_RS04420	COG1388	LysM domain
NIAKO_RS04420	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIAKO_RS04430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIAKO_RS04440	COG0492	ferredoxin-NADP+ reductase activity
NIAKO_RS04455	COG0534	Mate efflux family protein
NIAKO_RS04470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NIAKO_RS04480	COG1663	tetraacyldisaccharide 4'-kinase activity
NIAKO_RS04485	COG0557	exoribonuclease II activity
NIAKO_RS04495	COG0531	amino acid
NIAKO_RS04510	COG1193	negative regulation of DNA recombination
NIAKO_RS04530	COG2353	YceI-like domain
NIAKO_RS04545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIAKO_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIAKO_RS04555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS04605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIAKO_RS04605	COG4651	solute:proton antiporter activity
NIAKO_RS04630	COG1428	Deoxynucleoside kinase
NIAKO_RS04635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIAKO_RS04640	COG0616	signal peptide processing
NIAKO_RS04660	COG4206	TonB-dependent receptor
NIAKO_RS04660	COG1629	transport
NIAKO_RS04685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NIAKO_RS04690	COG1595	DNA-templated transcription, initiation
NIAKO_RS04710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIAKO_RS04715	COG4977	sequence-specific DNA binding
NIAKO_RS04720	COG1070	Carbohydrate kinase
NIAKO_RS04725	COG2115	Belongs to the xylose isomerase family
NIAKO_RS04775	COG0542	response to heat
NIAKO_RS04780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIAKO_RS04780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIAKO_RS04800	COG0720	synthase
NIAKO_RS04825	COG0205	6-phosphofructokinase activity
NIAKO_RS04830	COG1091	dTDP-4-dehydrorhamnose reductase activity
NIAKO_RS04840	COG2235	arginine
NIAKO_RS04845	COG1960	acyl-CoA dehydrogenase activity
NIAKO_RS04850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NIAKO_RS04860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIAKO_RS04865	COG1473	amidohydrolase
NIAKO_RS04875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS04875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS04925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIAKO_RS04935	COG0436	Aminotransferase
NIAKO_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS04950	COG0237	dephospho-CoA kinase activity
NIAKO_RS04960	COG1862	Preprotein translocase
NIAKO_RS04970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIAKO_RS04975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIAKO_RS05025	COG0545	Peptidyl-prolyl cis-trans isomerase
NIAKO_RS05030	COG1760	l-serine dehydratase
NIAKO_RS05035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIAKO_RS05045	COG2211	Major facilitator Superfamily
NIAKO_RS05085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIAKO_RS05100	COG1193	negative regulation of DNA recombination
NIAKO_RS05115	COG3848	Pyruvate phosphate dikinase
NIAKO_RS05115	COG0574	Belongs to the PEP-utilizing enzyme family
NIAKO_RS05120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIAKO_RS05215	COG4585	Histidine kinase
NIAKO_RS05255	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS05295	COG0582	viral genome integration into host DNA
NIAKO_RS05305	COG0563	adenylate kinase activity
NIAKO_RS05405	COG0582	viral genome integration into host DNA
NIAKO_RS05420	COG0667	Aldo Keto reductase
NIAKO_RS05430	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIAKO_RS05435	COG0583	DNA-binding transcription factor activity
NIAKO_RS05445	COG2818	Glycosylase
NIAKO_RS05465	COG3511	phospholipase C
NIAKO_RS05485	COG1629	transport
NIAKO_RS05485	COG4206	TonB-dependent receptor
NIAKO_RS05535	COG2197	response regulator
NIAKO_RS05545	COG2197	response regulator
NIAKO_RS05550	COG0501	Belongs to the peptidase M48B family
NIAKO_RS05560	COG4585	Histidine kinase
NIAKO_RS05600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIAKO_RS05605	COG1959	2 iron, 2 sulfur cluster binding
NIAKO_RS05615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NIAKO_RS05625	COG1475	DNA binding
NIAKO_RS05630	COG1192	Involved in chromosome partitioning
NIAKO_RS05635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NIAKO_RS05645	COG1408	metallophosphoesterase
NIAKO_RS05670	COG0166	Belongs to the GPI family
NIAKO_RS05705	COG0412	Dienelactone hydrolase
NIAKO_RS05710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NIAKO_RS05735	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS05745	COG0540	Belongs to the ATCase OTCase family
NIAKO_RS05750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NIAKO_RS05765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIAKO_RS05810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NIAKO_RS05820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIAKO_RS05840	COG1295	ribonuclease BN
NIAKO_RS05845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NIAKO_RS05865	COG2204	response regulator
NIAKO_RS05870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS05875	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NIAKO_RS05880	COG2226	methyltransferase
NIAKO_RS05885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIAKO_RS05895	COG2814	Major facilitator Superfamily
NIAKO_RS05915	COG1136	(ABC) transporter
NIAKO_RS05915	COG0577	efflux transmembrane transporter activity
NIAKO_RS05930	COG0577	efflux transmembrane transporter activity
NIAKO_RS05935	COG1136	(ABC) transporter
NIAKO_RS05935	COG0577	efflux transmembrane transporter activity
NIAKO_RS05955	COG4191	Histidine kinase
NIAKO_RS05970	COG0012	GTP binding
NIAKO_RS05975	COG2715	membrane protein required for spore maturation
NIAKO_RS05990	COG1629	transport
NIAKO_RS05995	COG1349	DNA-binding transcription factor activity
NIAKO_RS06025	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIAKO_RS06040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NIAKO_RS06055	COG4771	TonB-dependent receptor
NIAKO_RS06060	COG0702	epimerase
NIAKO_RS06100	COG0628	permease
NIAKO_RS06110	COG0702	epimerase
NIAKO_RS06120	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NIAKO_RS06155	COG0513	Belongs to the DEAD box helicase family
NIAKO_RS06165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NIAKO_RS06185	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIAKO_RS06185	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIAKO_RS06185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIAKO_RS06185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NIAKO_RS06190	COG0493	'glutamate synthase
NIAKO_RS06195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NIAKO_RS06200	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
NIAKO_RS06205	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NIAKO_RS06220	COG0375	protein maturation
NIAKO_RS06225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIAKO_RS06230	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NIAKO_RS06235	COG0298	carbon dioxide binding
NIAKO_RS06275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS06280	COG4771	TonB-dependent receptor
NIAKO_RS06305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIAKO_RS06340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NIAKO_RS06350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS06355	COG0456	acetyltransferase
NIAKO_RS06360	COG0156	8-amino-7-oxononanoate synthase activity
NIAKO_RS06385	COG3292	Two component regulator propeller
NIAKO_RS06385	COG2205	protein histidine kinase activity
NIAKO_RS06385	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS06390	COG3292	Two component regulator propeller
NIAKO_RS06390	COG3292	Two component regulator propeller
NIAKO_RS06390	COG2205	protein histidine kinase activity
NIAKO_RS06390	COG2205	protein histidine kinase activity
NIAKO_RS06390	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS06390	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS06395	COG4771	TonB-dependent receptor
NIAKO_RS06400	COG0702	epimerase
NIAKO_RS06405	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS06415	COG0411	ABC transporter
NIAKO_RS06420	COG1126	abc transporter atp-binding protein
NIAKO_RS06425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIAKO_RS06445	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIAKO_RS06480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIAKO_RS06500	COG1902	pentaerythritol trinitrate reductase activity
NIAKO_RS06505	COG0604	alcohol dehydrogenase
NIAKO_RS06515	COG1132	(ABC) transporter
NIAKO_RS06520	COG1132	(ABC) transporter
NIAKO_RS06555	COG0577	efflux transmembrane transporter activity
NIAKO_RS06555	COG1136	(ABC) transporter
NIAKO_RS06575	COG4771	TonB-dependent receptor
NIAKO_RS06595	COG2205	protein histidine kinase activity
NIAKO_RS06595	COG3292	Two component regulator propeller
NIAKO_RS06595	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS06595	COG2205	protein histidine kinase activity
NIAKO_RS06595	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS06595	COG3292	Two component regulator propeller
NIAKO_RS06600	COG1629	transport
NIAKO_RS06600	COG4206	TonB-dependent receptor
NIAKO_RS06625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NIAKO_RS06640	COG0702	epimerase
NIAKO_RS06660	COG0702	epimerase
NIAKO_RS06665	COG1629	transport
NIAKO_RS06680	COG3250	beta-galactosidase activity
NIAKO_RS06700	COG2207	Transcriptional regulator
NIAKO_RS06715	COG2885	chlorophyll binding
NIAKO_RS06745	COG1073	alpha beta
NIAKO_RS06765	COG4771	TonB-dependent receptor
NIAKO_RS06770	COG0702	epimerase
NIAKO_RS06810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS06820	COG4771	TonB-dependent receptor
NIAKO_RS06830	COG1595	DNA-templated transcription, initiation
NIAKO_RS06850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIAKO_RS06875	COG2197	response regulator
NIAKO_RS06885	COG3209	COG3209 Rhs family protein
NIAKO_RS06910	COG2197	response regulator
NIAKO_RS06930	COG2186	Transcriptional regulator
NIAKO_RS06935	COG2223	nitrite transmembrane transporter activity
NIAKO_RS06950	COG1295	ribonuclease BN
NIAKO_RS06960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NIAKO_RS06965	COG0484	heat shock protein binding
NIAKO_RS06970	COG3118	belongs to the thioredoxin family
NIAKO_RS06975	COG1278	Cold shock
NIAKO_RS06980	COG0513	Belongs to the DEAD box helicase family
NIAKO_RS06990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIAKO_RS06990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIAKO_RS07015	COG4221	oxidoreductase activity
NIAKO_RS07045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS07050	COG0038	chloride channel
NIAKO_RS07060	COG1733	regulation of RNA biosynthetic process
NIAKO_RS07090	COG0789	Transcriptional regulator
NIAKO_RS07100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIAKO_RS07115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIAKO_RS07125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIAKO_RS07130	COG0724	RNA recognition motif
NIAKO_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS07170	COG5434	Belongs to the glycosyl hydrolase 28 family
NIAKO_RS07170	COG4632	Exopolysaccharide biosynthesis protein
NIAKO_RS07205	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIAKO_RS07215	COG1629	transport
NIAKO_RS07220	COG0702	epimerase
NIAKO_RS07255	COG3384	dioxygenase
NIAKO_RS07285	COG3275	phosphorelay sensor kinase activity
NIAKO_RS07290	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS07305	COG4804	nuclease activity
NIAKO_RS07385	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS07410	COG2814	Major facilitator Superfamily
NIAKO_RS07420	COG4989	oxidoreductase activity
NIAKO_RS07425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NIAKO_RS07440	COG1404	Belongs to the peptidase S8 family
NIAKO_RS07450	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS07460	COG0010	Belongs to the arginase family
NIAKO_RS07470	COG1138	Cytochrome C-type biogenesis protein
NIAKO_RS07480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NIAKO_RS07480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NIAKO_RS07490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NIAKO_RS07495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NIAKO_RS07500	COG0297	glycogen (starch) synthase activity
NIAKO_RS07505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NIAKO_RS07515	COG0494	nUDIX hydrolase
NIAKO_RS07520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIAKO_RS07535	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS07550	COG0156	8-amino-7-oxononanoate synthase activity
NIAKO_RS07560	COG2366	antibiotic biosynthetic process
NIAKO_RS07580	COG1054	Belongs to the UPF0176 family
NIAKO_RS07585	COG2706	6-phosphogluconolactonase activity
NIAKO_RS07600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NIAKO_RS07610	COG1136	(ABC) transporter
NIAKO_RS07610	COG0577	efflux transmembrane transporter activity
NIAKO_RS07615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NIAKO_RS07625	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS07625	COG2885	chlorophyll binding
NIAKO_RS07645	COG2181	nitrate reductase activity
NIAKO_RS07645	COG0247	lactate metabolic process
NIAKO_RS07660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIAKO_RS07675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIAKO_RS07680	COG0577	efflux transmembrane transporter activity
NIAKO_RS07690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIAKO_RS07705	COG1196	nuclear chromosome segregation
NIAKO_RS07745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NIAKO_RS07775	COG2267	carboxylic ester hydrolase activity
NIAKO_RS07785	COG0183	Belongs to the thiolase family
NIAKO_RS07800	COG0629	single-stranded DNA binding
NIAKO_RS07810	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS07825	COG0022	dehydrogenase e1 component
NIAKO_RS07825	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIAKO_RS07870	COG0681	Belongs to the peptidase S26 family
NIAKO_RS07875	COG0295	cytidine deaminase activity
NIAKO_RS07885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIAKO_RS07890	COG0604	alcohol dehydrogenase
NIAKO_RS07900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIAKO_RS07905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIAKO_RS07910	COG1764	response to oxidative stress
NIAKO_RS07920	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS07940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NIAKO_RS07945	COG1984	allophanate hydrolase subunit 2
NIAKO_RS07950	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NIAKO_RS07955	COG1914	H( )-stimulated, divalent metal cation uptake system
NIAKO_RS07980	COG4399	Belongs to the UPF0754 family
NIAKO_RS07990	COG0793	Belongs to the peptidase S41A family
NIAKO_RS07995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NIAKO_RS08005	COG0424	maF-like protein
NIAKO_RS08015	COG0463	Glycosyl transferase, family 2
NIAKO_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08045	COG4771	TonB-dependent receptor
NIAKO_RS08055	COG1733	regulation of RNA biosynthetic process
NIAKO_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08075	COG0668	transmembrane transport
NIAKO_RS08080	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08085	COG1053	succinate dehydrogenase
NIAKO_RS08140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIAKO_RS08145	COG1881	PFAM PEBP family protein
NIAKO_RS08165	COG1629	transport
NIAKO_RS08170	COG0561	phosphatase activity
NIAKO_RS08175	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS08235	COG0513	Belongs to the DEAD box helicase family
NIAKO_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIAKO_RS08300	COG0724	RNA recognition motif
NIAKO_RS08320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIAKO_RS08430	COG0561	phosphatase activity
NIAKO_RS08470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIAKO_RS08475	COG2207	Transcriptional regulator
NIAKO_RS08475	COG4753	response regulator
NIAKO_RS08485	COG0667	Aldo Keto reductase
NIAKO_RS08500	COG4221	oxidoreductase activity
NIAKO_RS08505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIAKO_RS08530	COG4585	Histidine kinase
NIAKO_RS08535	COG2197	response regulator
NIAKO_RS08550	COG3604	Transcriptional regulator
NIAKO_RS08560	COG3604	Transcriptional regulator
NIAKO_RS08605	COG0702	epimerase
NIAKO_RS08610	COG1629	transport
NIAKO_RS08630	COG1764	response to oxidative stress
NIAKO_RS08635	COG3708	Transcriptional regulator
NIAKO_RS08635	COG2207	Transcriptional regulator
NIAKO_RS08665	COG2353	YceI-like domain
NIAKO_RS08675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIAKO_RS08705	COG0515	serine threonine protein kinase
NIAKO_RS08705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIAKO_RS08785	COG2207	Transcriptional regulator
NIAKO_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS08855	COG4682	membrane
NIAKO_RS08865	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS08870	COG2197	response regulator
NIAKO_RS08890	COG2824	Alkylphosphonate utilization operon protein PhnA
NIAKO_RS08900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NIAKO_RS08900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIAKO_RS08905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIAKO_RS08910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIAKO_RS08925	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS08955	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NIAKO_RS08960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIAKO_RS08970	COG0579	oxidoreductase
NIAKO_RS09010	COG4771	TonB-dependent receptor
NIAKO_RS09080	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS09115	COG2322	membrane
NIAKO_RS09145	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS09150	COG5002	protein histidine kinase activity
NIAKO_RS09165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIAKO_RS09225	COG1127	ABC transporter
NIAKO_RS09230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIAKO_RS09250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIAKO_RS09250	COG0574	Belongs to the PEP-utilizing enzyme family
NIAKO_RS09260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIAKO_RS09265	COG1127	ABC transporter
NIAKO_RS09275	COG1063	alcohol dehydrogenase
NIAKO_RS09300	COG0058	SHG alpha-glucan phosphorylase activity
NIAKO_RS09330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS09345	COG1994	Peptidase M50
NIAKO_RS09345	COG0517	IMP dehydrogenase activity
NIAKO_RS09350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIAKO_RS09365	COG4591	ABC-type transport system involved in lipoprotein release permease component
NIAKO_RS09375	COG3119	arylsulfatase activity
NIAKO_RS09375	COG3408	Glycogen debranching enzyme
NIAKO_RS09380	COG3119	arylsulfatase activity
NIAKO_RS09395	COG0726	polysaccharide deacetylase
NIAKO_RS09400	COG0463	Glycosyl transferase, family 2
NIAKO_RS09410	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS09420	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS09420	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS09470	COG4206	TonB-dependent receptor
NIAKO_RS09470	COG1629	transport
NIAKO_RS09480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS09525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIAKO_RS09540	COG2217	Heavy metal translocating P-type atpase
NIAKO_RS09545	COG3278	Belongs to the heme-copper respiratory oxidase family
NIAKO_RS09575	COG2205	protein histidine kinase activity
NIAKO_RS09610	COG1752	Esterase of the alpha-beta hydrolase superfamily
NIAKO_RS09660	COG3842	ATPase activity
NIAKO_RS09690	COG0561	phosphatase activity
NIAKO_RS09760	COG0697	spore germination
NIAKO_RS09765	COG2171	N-acyltransferase activity
NIAKO_RS09780	COG0009	L-threonylcarbamoyladenylate synthase
NIAKO_RS09790	COG0517	IMP dehydrogenase activity
NIAKO_RS09790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NIAKO_RS09790	COG0617	tRNA 3'-terminal CCA addition
NIAKO_RS09800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NIAKO_RS09820	COG4771	TonB-dependent receptor
NIAKO_RS09845	COG0442	prolyl-tRNA aminoacylation
NIAKO_RS09880	COG0714	Associated with various cellular activities
NIAKO_RS09890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NIAKO_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIAKO_RS09925	COG0105	UTP biosynthetic process
NIAKO_RS09935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NIAKO_RS09940	COG0545	Peptidyl-prolyl cis-trans isomerase
NIAKO_RS09945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIAKO_RS09955	COG0601	transmembrane transport
NIAKO_RS09965	COG0288	reversible hydration of carbon dioxide
NIAKO_RS09975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIAKO_RS09980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIAKO_RS09990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NIAKO_RS09995	COG0247	lactate metabolic process
NIAKO_RS10005	COG0330	HflC and HflK could
NIAKO_RS10015	COG1187	pseudouridine synthase activity
NIAKO_RS10020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIAKO_RS10025	COG0564	pseudouridine synthase activity
NIAKO_RS10050	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS10060	COG4221	oxidoreductase activity
NIAKO_RS10100	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIAKO_RS10110	COG2304	oxidoreductase activity
NIAKO_RS10120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NIAKO_RS10150	COG3850	Histidine kinase
NIAKO_RS10150	COG5002	protein histidine kinase activity
NIAKO_RS10160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIAKO_RS10195	COG1132	(ABC) transporter
NIAKO_RS10205	COG0837	glucose binding
NIAKO_RS10240	COG3250	beta-galactosidase activity
NIAKO_RS10260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIAKO_RS10280	COG0730	response to heat
NIAKO_RS10290	COG0285	dihydrofolate synthase activity
NIAKO_RS10295	COG0494	nUDIX hydrolase
NIAKO_RS10320	COG0527	aspartate kinase activity
NIAKO_RS10340	COG0443	Heat shock 70 kDa protein
NIAKO_RS10365	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS10365	COG2207	Transcriptional regulator
NIAKO_RS10370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIAKO_RS10370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIAKO_RS10385	COG0018	arginyl-trna synthetase
NIAKO_RS10395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIAKO_RS10425	COG1360	Flagellar Motor Protein
NIAKO_RS10470	COG0252	asparaginase activity
NIAKO_RS10520	COG1360	Flagellar Motor Protein
NIAKO_RS10540	COG0596	Alpha beta hydrolase
NIAKO_RS10585	COG0366	Alpha amylase catalytic
NIAKO_RS10595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIAKO_RS10600	COG0297	glycogen (starch) synthase activity
NIAKO_RS10610	COG1940	carbohydrate kinase activity
NIAKO_RS10620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIAKO_RS10690	COG0149	triose-phosphate isomerase activity
NIAKO_RS10695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIAKO_RS10700	COG0254	rRNA binding
NIAKO_RS10705	COG1666	GTP binding
NIAKO_RS10735	COG0071	Belongs to the small heat shock protein (HSP20) family
NIAKO_RS10750	COG1166	arginine decarboxylase activity
NIAKO_RS10755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NIAKO_RS10760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NIAKO_RS10765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NIAKO_RS10770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIAKO_RS10800	COG0488	(ABC) transporter
NIAKO_RS10810	COG1752	Esterase of the alpha-beta hydrolase superfamily
NIAKO_RS10825	COG1228	amidohydrolase
NIAKO_RS10840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NIAKO_RS10845	COG2986	histidine ammonia-lyase
NIAKO_RS10850	COG0583	DNA-binding transcription factor activity
NIAKO_RS10855	COG2211	Major facilitator Superfamily
NIAKO_RS10860	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS10870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIAKO_RS10875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NIAKO_RS10880	COG2181	nitrate reductase activity
NIAKO_RS10880	COG0247	lactate metabolic process
NIAKO_RS10915	COG3239	Fatty acid desaturase
NIAKO_RS10965	COG3685	Protein conserved in bacteria
NIAKO_RS10975	COG0859	PFAM glycosyl transferase family 9
NIAKO_RS10980	COG1216	Glycosyl transferase, family 2
NIAKO_RS10985	COG2192	nodulation
NIAKO_RS10995	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS11025	COG2217	Heavy metal translocating P-type atpase
NIAKO_RS11040	COG0488	(ABC) transporter
NIAKO_RS11060	COG4771	TonB-dependent receptor
NIAKO_RS11095	COG4977	sequence-specific DNA binding
NIAKO_RS11095	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS11155	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NIAKO_RS11165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIAKO_RS11165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIAKO_RS11170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIAKO_RS11210	COG4251	negative regulation of phosphorylation
NIAKO_RS11215	COG0071	Belongs to the small heat shock protein (HSP20) family
NIAKO_RS11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS11285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIAKO_RS11295	COG0022	dehydrogenase e1 component
NIAKO_RS11295	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIAKO_RS11300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIAKO_RS11305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIAKO_RS11310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NIAKO_RS11310	COG1796	DNA polymerase
NIAKO_RS11315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIAKO_RS11325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIAKO_RS11350	COG1131	(ABC) transporter
NIAKO_RS11355	COG1131	(ABC) transporter
NIAKO_RS11360	COG0842	Transport permease protein
NIAKO_RS11365	COG0842	Transport permease protein
NIAKO_RS11370	COG0577	efflux transmembrane transporter activity
NIAKO_RS11370	COG1136	(ABC) transporter
NIAKO_RS11380	COG0575	Belongs to the CDS family
NIAKO_RS11385	COG3383	formate dehydrogenase (NAD+) activity
NIAKO_RS11410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIAKO_RS11455	COG2197	response regulator
NIAKO_RS11470	COG2366	antibiotic biosynthetic process
NIAKO_RS11510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NIAKO_RS11550	COG1595	DNA-templated transcription, initiation
NIAKO_RS11615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS11665	COG4206	TonB-dependent receptor
NIAKO_RS11665	COG1629	transport
NIAKO_RS11680	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS11680	COG2205	protein histidine kinase activity
NIAKO_RS11680	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS11680	COG3292	Two component regulator propeller
NIAKO_RS11680	COG3292	Two component regulator propeller
NIAKO_RS11680	COG2205	protein histidine kinase activity
NIAKO_RS11685	COG0702	epimerase
NIAKO_RS11690	COG4771	TonB-dependent receptor
NIAKO_RS11700	COG3254	rhamnose metabolic process
NIAKO_RS11710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NIAKO_RS11710	COG5297	Belongs to the glycosyl hydrolase family 6
NIAKO_RS11725	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NIAKO_RS11735	COG0561	phosphatase activity
NIAKO_RS11740	COG4771	TonB-dependent receptor
NIAKO_RS11755	COG1629	transport
NIAKO_RS11760	COG1501	Belongs to the glycosyl hydrolase 31 family
NIAKO_RS11765	COG3250	beta-galactosidase activity
NIAKO_RS11775	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS11780	COG3250	beta-galactosidase activity
NIAKO_RS11785	COG3292	Two component regulator propeller
NIAKO_RS11785	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS11785	COG2205	protein histidine kinase activity
NIAKO_RS11840	COG0702	epimerase
NIAKO_RS11845	COG4771	TonB-dependent receptor
NIAKO_RS11880	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS11885	COG3275	phosphorelay sensor kinase activity
NIAKO_RS11895	COG3250	beta-galactosidase activity
NIAKO_RS11900	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS11930	COG0561	phosphatase activity
NIAKO_RS11935	COG4771	TonB-dependent receptor
NIAKO_RS11965	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS11970	COG1501	Belongs to the glycosyl hydrolase 31 family
NIAKO_RS11980	COG2382	esterase
NIAKO_RS11985	COG0702	epimerase
NIAKO_RS11990	COG1629	transport
NIAKO_RS12010	COG4771	TonB-dependent receptor
NIAKO_RS12020	COG4771	TonB-dependent receptor
NIAKO_RS12035	COG2382	esterase
NIAKO_RS12035	COG3693	PFAM glycoside hydrolase, family 10
NIAKO_RS12035	COG3507	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS12040	COG3534	alpha-L-arabinofuranosidase
NIAKO_RS12045	COG2382	esterase
NIAKO_RS12050	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS12055	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS12055	COG2205	protein histidine kinase activity
NIAKO_RS12055	COG3292	Two component regulator propeller
NIAKO_RS12135	COG0656	L-ascorbic acid biosynthetic process
NIAKO_RS12170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS12190	COG0604	alcohol dehydrogenase
NIAKO_RS12240	COG1629	transport
NIAKO_RS12240	COG4206	TonB-dependent receptor
NIAKO_RS12275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NIAKO_RS12320	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NIAKO_RS12325	COG3959	Transketolase, thiamine diphosphate binding domain
NIAKO_RS12380	COG4941	Belongs to the sigma-70 factor family
NIAKO_RS12415	COG1609	Transcriptional regulator
NIAKO_RS12440	COG0346	lactoylglutathione lyase activity
NIAKO_RS12455	COG3408	Glycogen debranching enzyme
NIAKO_RS12460	COG5634	Uncharacterized conserved protein (DUF2278)
NIAKO_RS12475	COG1733	regulation of RNA biosynthetic process
NIAKO_RS12480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NIAKO_RS12495	COG4771	TonB-dependent receptor
NIAKO_RS12520	COG1404	Belongs to the peptidase S8 family
NIAKO_RS12520	COG4412	M6 family metalloprotease domain protein
NIAKO_RS12535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIAKO_RS12540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIAKO_RS12550	COG0463	Glycosyl transferase, family 2
NIAKO_RS12575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NIAKO_RS12590	COG0481	GTPase activity
NIAKO_RS12625	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS12630	COG1640	4-alpha-glucanotransferase
NIAKO_RS12640	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NIAKO_RS12645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIAKO_RS12650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS12655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIAKO_RS12665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NIAKO_RS12675	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NIAKO_RS12685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIAKO_RS12690	COG3938	Belongs to the proline racemase family
NIAKO_RS12700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS12710	COG0552	protein localization to endoplasmic reticulum
NIAKO_RS12715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NIAKO_RS12725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIAKO_RS12730	COG0248	Ppx GppA phosphatase
NIAKO_RS12735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NIAKO_RS12750	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS12825	COG0542	response to heat
NIAKO_RS12835	COG0791	NLP P60 protein
NIAKO_RS12875	COG1280	lysine exporter protein (LysE YggA)
NIAKO_RS12890	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NIAKO_RS12895	COG0788	formyltetrahydrofolate deformylase activity
NIAKO_RS12900	COG1629	transport
NIAKO_RS12900	COG4206	TonB-dependent receptor
NIAKO_RS12950	COG0358	DNA primase activity
NIAKO_RS12970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NIAKO_RS12975	COG2264	protein methyltransferase activity
NIAKO_RS12980	COG1185	polyribonucleotide nucleotidyltransferase activity
NIAKO_RS12985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NIAKO_RS13000	COG2884	Cell division ATP-binding protein ftsE
NIAKO_RS13005	COG4773	Receptor
NIAKO_RS13020	COG0583	DNA-binding transcription factor activity
NIAKO_RS13025	COG2855	membrane
NIAKO_RS13060	COG3693	PFAM glycoside hydrolase, family 10
NIAKO_RS13070	COG0561	phosphatase activity
NIAKO_RS13075	COG4771	TonB-dependent receptor
NIAKO_RS13095	COG4771	TonB-dependent receptor
NIAKO_RS13120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NIAKO_RS13155	COG1629	transport
NIAKO_RS13175	COG2731	YhcH YjgK YiaL family protein
NIAKO_RS13190	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS13195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NIAKO_RS13200	COG0066	3-isopropylmalate dehydratase activity
NIAKO_RS13215	COG0473	3-isopropylmalate dehydrogenase activity
NIAKO_RS13225	COG2610	gluconate transmembrane transporter activity
NIAKO_RS13230	COG2084	Dehydrogenase
NIAKO_RS13235	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS13250	COG1357	PFAM Pentapeptide repeats (8 copies)
NIAKO_RS13250	COG0515	serine threonine protein kinase
NIAKO_RS13300	COG4771	TonB-dependent receptor
NIAKO_RS13315	COG1595	DNA-templated transcription, initiation
NIAKO_RS13355	COG1629	transport
NIAKO_RS13355	COG4206	TonB-dependent receptor
NIAKO_RS13365	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS13385	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS13410	COG4771	TonB-dependent receptor
NIAKO_RS13415	COG0702	epimerase
NIAKO_RS13425	COG2226	methyltransferase
NIAKO_RS13425	COG0596	Alpha beta hydrolase
NIAKO_RS13425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIAKO_RS13435	COG0784	Response regulator, receiver
NIAKO_RS13450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NIAKO_RS13455	COG0784	Response regulator, receiver
NIAKO_RS13455	COG2205	protein histidine kinase activity
NIAKO_RS13470	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS13470	COG3292	Two component regulator propeller
NIAKO_RS13470	COG2205	protein histidine kinase activity
NIAKO_RS13485	COG2949	membrane
NIAKO_RS13490	COG0784	Response regulator, receiver
NIAKO_RS13495	COG4251	negative regulation of phosphorylation
NIAKO_RS13505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NIAKO_RS13520	COG0726	polysaccharide deacetylase
NIAKO_RS13530	COG0492	ferredoxin-NADP+ reductase activity
NIAKO_RS13590	COG2175	clavaminate synthase activity
NIAKO_RS13595	COG0076	glutamate decarboxylase activity
NIAKO_RS13605	COG3486	L-lysine 6-monooxygenase (NADPH) activity
NIAKO_RS13625	COG0318	PFAM AMP-dependent synthetase and ligase
NIAKO_RS13640	COG1629	transport
NIAKO_RS13640	COG4206	TonB-dependent receptor
NIAKO_RS13655	COG4771	TonB-dependent receptor
NIAKO_RS13700	COG2885	chlorophyll binding
NIAKO_RS13735	COG1595	DNA-templated transcription, initiation
NIAKO_RS13760	COG1629	transport
NIAKO_RS13790	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS13790	COG3292	Two component regulator propeller
NIAKO_RS13790	COG2205	protein histidine kinase activity
NIAKO_RS13795	COG1629	transport
NIAKO_RS13800	COG0702	epimerase
NIAKO_RS13805	COG3250	beta-galactosidase activity
NIAKO_RS13810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS13830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS13840	COG1538	Outer membrane efflux protein
NIAKO_RS13860	COG4206	TonB-dependent receptor
NIAKO_RS13860	COG1629	transport
NIAKO_RS13885	COG4977	sequence-specific DNA binding
NIAKO_RS13910	COG2076	Multidrug Resistance protein
NIAKO_RS13915	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS13925	COG0385	Bile acid
NIAKO_RS13935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NIAKO_RS13940	COG1070	Carbohydrate kinase
NIAKO_RS13950	COG1629	transport
NIAKO_RS13950	COG4206	TonB-dependent receptor
NIAKO_RS13960	COG0129	dihydroxy-acid dehydratase activity
NIAKO_RS13975	COG2270	Major facilitator Superfamily
NIAKO_RS13985	COG3507	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS14010	COG3387	PFAM Glycoside hydrolase 15-related
NIAKO_RS14025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIAKO_RS14030	COG3511	phospholipase C
NIAKO_RS14150	COG1733	regulation of RNA biosynthetic process
NIAKO_RS14155	COG2910	NAD(P)H-binding
NIAKO_RS14165	COG1629	transport
NIAKO_RS14165	COG4206	TonB-dependent receptor
NIAKO_RS14170	COG3292	Two component regulator propeller
NIAKO_RS14170	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS14170	COG2205	protein histidine kinase activity
NIAKO_RS14175	COG0667	Aldo Keto reductase
NIAKO_RS14180	COG1741	Belongs to the pirin family
NIAKO_RS14200	COG0702	epimerase
NIAKO_RS14205	COG4771	TonB-dependent receptor
NIAKO_RS14220	COG2059	Chromate
NIAKO_RS14260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIAKO_RS14275	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS14340	COG2814	Major facilitator Superfamily
NIAKO_RS14365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NIAKO_RS14380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIAKO_RS14395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS14400	COG4585	Histidine kinase
NIAKO_RS14405	COG2201	protein-glutamate methylesterase activity
NIAKO_RS14500	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIAKO_RS14520	COG1858	cytochrome C peroxidase
NIAKO_RS14535	COG1007	ATP synthesis coupled electron transport
NIAKO_RS14550	COG0713	ATP synthesis coupled electron transport
NIAKO_RS14560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS14565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIAKO_RS14585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS14585	COG0649	NAD binding
NIAKO_RS14590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS14595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS14600	COG0517	IMP dehydrogenase activity
NIAKO_RS14615	COG4771	TonB-dependent receptor
NIAKO_RS14670	COG0702	epimerase
NIAKO_RS14675	COG4771	TonB-dependent receptor
NIAKO_RS14680	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS14680	COG3292	Two component regulator propeller
NIAKO_RS14680	COG2205	protein histidine kinase activity
NIAKO_RS14710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NIAKO_RS14720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NIAKO_RS14720	COG1199	ATP-dependent helicase activity
NIAKO_RS14725	COG0525	valine-tRNA ligase activity
NIAKO_RS14730	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS14735	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS14740	COG1366	Belongs to the anti-sigma-factor antagonist family
NIAKO_RS14745	COG1366	Belongs to the anti-sigma-factor antagonist family
NIAKO_RS14750	COG2172	sigma factor antagonist activity
NIAKO_RS14760	COG4251	negative regulation of phosphorylation
NIAKO_RS14765	COG2201	protein-glutamate methylesterase activity
NIAKO_RS14775	COG2339	peptidase activity
NIAKO_RS14780	COG0456	acetyltransferase
NIAKO_RS14785	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NIAKO_RS14810	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS14810	COG2972	Histidine kinase
NIAKO_RS14815	COG3275	phosphorelay sensor kinase activity
NIAKO_RS14850	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NIAKO_RS14865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NIAKO_RS14890	COG0577	efflux transmembrane transporter activity
NIAKO_RS14890	COG1136	(ABC) transporter
NIAKO_RS14895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NIAKO_RS14900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NIAKO_RS14920	COG1595	DNA-templated transcription, initiation
NIAKO_RS15065	COG2197	response regulator
NIAKO_RS15070	COG4585	Histidine kinase
NIAKO_RS15080	COG2205	protein histidine kinase activity
NIAKO_RS15080	COG0784	Response regulator, receiver
NIAKO_RS15110	COG4771	TonB-dependent receptor
NIAKO_RS15175	COG4771	TonB-dependent receptor
NIAKO_RS15185	COG4771	TonB-dependent receptor
NIAKO_RS15195	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS15205	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS15225	COG1858	cytochrome C peroxidase
NIAKO_RS15235	COG3537	Alpha-1,2-mannosidase
NIAKO_RS15265	COG1696	Membrane protein involved in D-alanine export
NIAKO_RS15275	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS15290	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS15305	COG4771	TonB-dependent receptor
NIAKO_RS15310	COG2205	protein histidine kinase activity
NIAKO_RS15310	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS15310	COG3292	Two component regulator propeller
NIAKO_RS15365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NIAKO_RS15375	COG1058	Belongs to the CinA family
NIAKO_RS15375	COG1546	Belongs to the CinA family
NIAKO_RS15380	COG3685	Protein conserved in bacteria
NIAKO_RS15390	COG1511	domain protein
NIAKO_RS15390	COG3264	Mechanosensitive ion channel
NIAKO_RS15400	COG4251	negative regulation of phosphorylation
NIAKO_RS15440	COG1609	Transcriptional regulator
NIAKO_RS15460	COG4771	TonB-dependent receptor
NIAKO_RS15515	COG1073	alpha beta
NIAKO_RS15555	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NIAKO_RS15615	COG1278	Cold shock
NIAKO_RS15625	COG0724	RNA recognition motif
NIAKO_RS15630	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NIAKO_RS15635	COG4251	negative regulation of phosphorylation
NIAKO_RS15645	COG4251	negative regulation of phosphorylation
NIAKO_RS15650	COG2201	protein-glutamate methylesterase activity
NIAKO_RS15675	COG0587	DNA-directed DNA polymerase activity
NIAKO_RS15685	COG0688	phosphatidylethanolamine metabolic process
NIAKO_RS15695	COG3685	Protein conserved in bacteria
NIAKO_RS15705	COG4251	negative regulation of phosphorylation
NIAKO_RS15710	COG0189	ligase activity
NIAKO_RS15710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIAKO_RS15735	COG4771	TonB-dependent receptor
NIAKO_RS15740	COG4771	TonB-dependent receptor
NIAKO_RS15750	COG0793	Belongs to the peptidase S41A family
NIAKO_RS15755	COG2226	methyltransferase
NIAKO_RS15785	COG0494	nUDIX hydrolase
NIAKO_RS15810	COG1733	regulation of RNA biosynthetic process
NIAKO_RS15845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS15850	COG4771	TonB-dependent receptor
NIAKO_RS15860	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS15860	COG3292	Two component regulator propeller
NIAKO_RS15860	COG2205	protein histidine kinase activity
NIAKO_RS15865	COG0754	glutathionylspermidine amidase activity
NIAKO_RS15885	COG0477	Major facilitator Superfamily
NIAKO_RS15920	COG2197	response regulator
NIAKO_RS15925	COG2205	protein histidine kinase activity
NIAKO_RS15940	COG0702	epimerase
NIAKO_RS15945	COG1629	transport
NIAKO_RS16030	COG0628	permease
NIAKO_RS16090	COG2205	protein histidine kinase activity
NIAKO_RS16110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIAKO_RS16200	COG1858	cytochrome C peroxidase
NIAKO_RS16260	COG2197	response regulator
NIAKO_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS16320	COG4565	transcriptional regulatory protein
NIAKO_RS16355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS16405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIAKO_RS16410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS16415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS16435	COG2192	nodulation
NIAKO_RS16480	COG2514	catechol 2,3-dioxygenase activity
NIAKO_RS16505	COG1136	(ABC) transporter
NIAKO_RS16505	COG0577	efflux transmembrane transporter activity
NIAKO_RS16520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS16525	COG1629	transport
NIAKO_RS16525	COG4206	TonB-dependent receptor
NIAKO_RS16545	COG1733	regulation of RNA biosynthetic process
NIAKO_RS16565	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS16565	COG2207	Transcriptional regulator
NIAKO_RS16575	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NIAKO_RS16580	COG0288	reversible hydration of carbon dioxide
NIAKO_RS16600	COG1752	Esterase of the alpha-beta hydrolase superfamily
NIAKO_RS16655	COG4974	Belongs to the 'phage' integrase family
NIAKO_RS16665	COG3093	addiction module antidote protein HigA
NIAKO_RS16820	COG1595	DNA-templated transcription, initiation
NIAKO_RS16865	COG4771	TonB-dependent receptor
NIAKO_RS16915	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NIAKO_RS16925	COG0640	Transcriptional regulator
NIAKO_RS16955	COG1629	transport
NIAKO_RS16980	COG1418	mRNA catabolic process
NIAKO_RS17005	COG1629	transport
NIAKO_RS17005	COG4206	TonB-dependent receptor
NIAKO_RS17015	COG0724	RNA recognition motif
NIAKO_RS17050	COG0667	Aldo Keto reductase
NIAKO_RS17065	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS17080	COG0640	Transcriptional regulator
NIAKO_RS17110	COG1733	regulation of RNA biosynthetic process
NIAKO_RS17120	COG0659	secondary active sulfate transmembrane transporter activity
NIAKO_RS17145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIAKO_RS17155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIAKO_RS17195	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS17210	COG0702	epimerase
NIAKO_RS17215	COG4771	TonB-dependent receptor
NIAKO_RS17230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIAKO_RS17240	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS17265	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS17275	COG0406	alpha-ribazole phosphatase activity
NIAKO_RS17285	COG1070	Carbohydrate kinase
NIAKO_RS17290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIAKO_RS17295	COG2814	Major facilitator Superfamily
NIAKO_RS17305	COG1349	DNA-binding transcription factor activity
NIAKO_RS17320	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NIAKO_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS17335	COG0628	permease
NIAKO_RS17415	COG1785	Belongs to the alkaline phosphatase family
NIAKO_RS17425	COG4771	TonB-dependent receptor
NIAKO_RS17435	COG1595	DNA-templated transcription, initiation
NIAKO_RS17455	COG4771	TonB-dependent receptor
NIAKO_RS17465	COG2197	response regulator
NIAKO_RS17470	COG0477	Major facilitator Superfamily
NIAKO_RS17470	COG2814	Major facilitator Superfamily
NIAKO_RS17475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS17480	COG0457	Tetratricopeptide repeat
NIAKO_RS17485	COG2814	Major facilitator Superfamily
NIAKO_RS17580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NIAKO_RS17585	COG2022	thiamine diphosphate biosynthetic process
NIAKO_RS17590	COG0352	thiamine-phosphate diphosphorylase activity
NIAKO_RS17605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NIAKO_RS17645	COG3940	Belongs to the glycosyl hydrolase 43 family
NIAKO_RS17680	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS17705	COG3395	kinase activity
NIAKO_RS17710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIAKO_RS17715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS17720	COG1454	alcohol dehydrogenase
NIAKO_RS17725	COG3250	beta-galactosidase activity
NIAKO_RS17770	COG4771	TonB-dependent receptor
NIAKO_RS17780	COG3250	beta-galactosidase activity
NIAKO_RS17795	COG3250	beta-galactosidase activity
NIAKO_RS17830	COG4771	TonB-dependent receptor
NIAKO_RS17860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NIAKO_RS17880	COG0738	Major facilitator superfamily
NIAKO_RS17885	COG1069	ribulokinase activity
NIAKO_RS17895	COG2160	L-arabinose isomerase activity
NIAKO_RS17915	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS17920	COG3401	FG-GAP repeat protein
NIAKO_RS17965	COG4251	negative regulation of phosphorylation
NIAKO_RS17970	COG3408	Glycogen debranching enzyme
NIAKO_RS17975	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS17990	COG4952	isomerase
NIAKO_RS17995	COG3254	rhamnose metabolic process
NIAKO_RS18000	COG3347	Dehydrogenase
NIAKO_RS18000	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS18045	COG2610	gluconate transmembrane transporter activity
NIAKO_RS18055	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS18085	COG1363	Peptidase, m42
NIAKO_RS18105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NIAKO_RS18110	COG2197	response regulator
NIAKO_RS18120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NIAKO_RS18130	COG1132	(ABC) transporter
NIAKO_RS18140	COG0366	Alpha amylase catalytic
NIAKO_RS18160	COG2814	Major facilitator Superfamily
NIAKO_RS18180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS18185	COG4771	TonB-dependent receptor
NIAKO_RS18225	COG1335	isochorismatase
NIAKO_RS18260	COG4206	TonB-dependent receptor
NIAKO_RS18335	COG4771	TonB-dependent receptor
NIAKO_RS18370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIAKO_RS18370	COG3321	synthase
NIAKO_RS18370	COG0604	alcohol dehydrogenase
NIAKO_RS18370	COG4221	oxidoreductase activity
NIAKO_RS18375	COG1678	Uncharacterized ACR, COG1678
NIAKO_RS18380	COG0366	Alpha amylase catalytic
NIAKO_RS18405	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS18415	COG3119	arylsulfatase activity
NIAKO_RS18480	COG3119	arylsulfatase activity
NIAKO_RS18485	COG3119	arylsulfatase activity
NIAKO_RS18510	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS18530	COG4771	TonB-dependent receptor
NIAKO_RS18535	COG0702	epimerase
NIAKO_RS18540	COG2885	chlorophyll binding
NIAKO_RS18545	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS18565	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS18575	COG2133	pyrroloquinoline quinone binding
NIAKO_RS18590	COG4771	TonB-dependent receptor
NIAKO_RS18595	COG3386	PFAM SMP-30 Gluconolaconase
NIAKO_RS18605	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS18615	COG1473	amidohydrolase
NIAKO_RS18620	COG0088	Forms part of the polypeptide exit tunnel
NIAKO_RS18655	COG2274	protein secretion by the type I secretion system
NIAKO_RS18665	COG2226	methyltransferase
NIAKO_RS18715	COG3621	Patatin-like phospholipase
NIAKO_RS18750	COG4206	TonB-dependent receptor
NIAKO_RS18750	COG1629	transport
NIAKO_RS18755	COG1523	belongs to the glycosyl hydrolase 13 family
NIAKO_RS18775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIAKO_RS18790	COG4206	TonB-dependent receptor
NIAKO_RS18790	COG1629	transport
NIAKO_RS18795	COG3590	peptidase
NIAKO_RS18835	COG1629	transport
NIAKO_RS18840	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS18840	COG2205	protein histidine kinase activity
NIAKO_RS18840	COG3292	Two component regulator propeller
NIAKO_RS18900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIAKO_RS18900	COG0574	Belongs to the PEP-utilizing enzyme family
NIAKO_RS18945	COG3119	arylsulfatase activity
NIAKO_RS18970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS18985	COG0300	oxidoreductase activity
NIAKO_RS19095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIAKO_RS19100	COG1595	DNA-templated transcription, initiation
NIAKO_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS19150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NIAKO_RS19150	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS19155	COG0667	Aldo Keto reductase
NIAKO_RS19165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIAKO_RS19180	COG0456	acetyltransferase
NIAKO_RS19190	COG4771	TonB-dependent receptor
NIAKO_RS19195	COG1349	DNA-binding transcription factor activity
NIAKO_RS19205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS19215	COG4941	Belongs to the sigma-70 factor family
NIAKO_RS19225	COG3189	MarR family transcriptional regulator
NIAKO_RS19245	COG2204	response regulator
NIAKO_RS19265	COG2885	chlorophyll binding
NIAKO_RS19365	COG1702	phosphate starvation-inducible protein PhoH
NIAKO_RS19385	COG0791	NLP P60 protein
NIAKO_RS19390	COG1595	DNA-templated transcription, initiation
NIAKO_RS19400	COG0590	tRNA wobble adenosine to inosine editing
NIAKO_RS19410	COG3142	Participates in the control of copper homeostasis
NIAKO_RS19415	COG1446	asparaginase
NIAKO_RS19425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIAKO_RS19430	COG0363	glucosamine-6-phosphate deaminase activity
NIAKO_RS19440	COG4565	transcriptional regulatory protein
NIAKO_RS19445	COG4251	negative regulation of phosphorylation
NIAKO_RS19505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NIAKO_RS19565	COG4372	Transposase
NIAKO_RS19590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS19640	COG1228	amidohydrolase
NIAKO_RS19685	COG0702	epimerase
NIAKO_RS19690	COG4771	TonB-dependent receptor
NIAKO_RS19735	COG0768	penicillin binding
NIAKO_RS19785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS19825	COG1136	(ABC) transporter
NIAKO_RS19830	COG0577	efflux transmembrane transporter activity
NIAKO_RS19830	COG1136	(ABC) transporter
NIAKO_RS19840	COG2204	response regulator
NIAKO_RS19900	COG1770	oligopeptidase
NIAKO_RS19905	COG2267	carboxylic ester hydrolase activity
NIAKO_RS19920	COG3842	ATPase activity
NIAKO_RS19965	COG4771	TonB-dependent receptor
NIAKO_RS19985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS19990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIAKO_RS20025	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS20035	COG2226	methyltransferase
NIAKO_RS20040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIAKO_RS20050	COG1595	DNA-templated transcription, initiation
NIAKO_RS20110	COG2996	Protein conserved in bacteria
NIAKO_RS20120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS20140	COG1629	transport
NIAKO_RS20140	COG4206	TonB-dependent receptor
NIAKO_RS20210	COG1629	transport
NIAKO_RS20210	COG4206	TonB-dependent receptor
NIAKO_RS20240	COG3250	beta-galactosidase activity
NIAKO_RS20245	COG2855	membrane
NIAKO_RS20270	COG5002	protein histidine kinase activity
NIAKO_RS20275	COG2205	protein histidine kinase activity
NIAKO_RS20285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NIAKO_RS20295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIAKO_RS20305	COG3158	transport of potassium into the cell
NIAKO_RS20310	COG2204	response regulator
NIAKO_RS20320	COG0037	tRNA processing
NIAKO_RS20335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NIAKO_RS20345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NIAKO_RS20350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIAKO_RS20365	COG2814	Major facilitator Superfamily
NIAKO_RS20405	COG1309	transcriptional regulator
NIAKO_RS20415	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS20420	COG4771	TonB-dependent receptor
NIAKO_RS20430	COG1595	DNA-templated transcription, initiation
NIAKO_RS20435	COG4771	TonB-dependent receptor
NIAKO_RS20440	COG0702	epimerase
NIAKO_RS20465	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS20485	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
NIAKO_RS20490	COG1959	2 iron, 2 sulfur cluster binding
NIAKO_RS20495	COG0596	Alpha beta hydrolase
NIAKO_RS20505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NIAKO_RS20515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NIAKO_RS20525	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIAKO_RS20535	COG1902	pentaerythritol trinitrate reductase activity
NIAKO_RS20540	COG1522	sequence-specific DNA binding
NIAKO_RS20545	COG1104	cysteine desulfurase activity
NIAKO_RS20560	COG1629	transport
NIAKO_RS20590	COG0730	response to heat
NIAKO_RS20600	COG1017	nitric oxide dioxygenase activity
NIAKO_RS20600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIAKO_RS20620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS20625	COG1174	glycine betaine transport
NIAKO_RS20630	COG1125	glycine betaine transport
NIAKO_RS20630	COG0517	IMP dehydrogenase activity
NIAKO_RS20635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIAKO_RS20640	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NIAKO_RS20690	COG3391	amine dehydrogenase activity
NIAKO_RS20710	COG5002	protein histidine kinase activity
NIAKO_RS20715	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS20730	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS20740	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS20765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIAKO_RS20785	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS20790	COG0028	Belongs to the TPP enzyme family
NIAKO_RS20800	COG0567	Dehydrogenase, E1 component
NIAKO_RS20805	COG3663	DNA glycosylase
NIAKO_RS20840	COG1629	transport
NIAKO_RS20855	COG0427	acetyl-CoA hydrolase
NIAKO_RS20875	COG0667	Aldo Keto reductase
NIAKO_RS20895	COG0702	epimerase
NIAKO_RS20900	COG4206	TonB-dependent receptor
NIAKO_RS20900	COG1629	transport
NIAKO_RS20920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NIAKO_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS20995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NIAKO_RS21035	COG2207	Transcriptional regulator
NIAKO_RS21050	COG4221	oxidoreductase activity
NIAKO_RS21055	COG4977	sequence-specific DNA binding
NIAKO_RS21060	COG4977	sequence-specific DNA binding
NIAKO_RS21100	COG0071	Belongs to the small heat shock protein (HSP20) family
NIAKO_RS21130	COG2132	Multicopper oxidase
NIAKO_RS21145	COG0071	Belongs to the small heat shock protein (HSP20) family
NIAKO_RS21155	COG2201	protein-glutamate methylesterase activity
NIAKO_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS21210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIAKO_RS21235	COG1132	(ABC) transporter
NIAKO_RS21255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS21260	COG2264	protein methyltransferase activity
NIAKO_RS21270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS21280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIAKO_RS21300	COG0416	fatty acid biosynthetic process
NIAKO_RS21325	COG0726	polysaccharide deacetylase
NIAKO_RS21335	COG1228	amidohydrolase
NIAKO_RS21350	COG0488	(ABC) transporter
NIAKO_RS21385	COG3118	belongs to the thioredoxin family
NIAKO_RS21390	COG0545	Peptidyl-prolyl cis-trans isomerase
NIAKO_RS21415	COG1914	H( )-stimulated, divalent metal cation uptake system
NIAKO_RS21430	COG0538	isocitrate dehydrogenase activity
NIAKO_RS21435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIAKO_RS21445	COG0583	DNA-binding transcription factor activity
NIAKO_RS21450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIAKO_RS21485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIAKO_RS21495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIAKO_RS21505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIAKO_RS21520	COG4585	Histidine kinase
NIAKO_RS21525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIAKO_RS21530	COG2942	2-epimerase
NIAKO_RS21535	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
NIAKO_RS21545	COG4124	Belongs to the glycosyl hydrolase 26 family
NIAKO_RS21560	COG4771	TonB-dependent receptor
NIAKO_RS21565	COG2207	Transcriptional regulator
NIAKO_RS21575	COG3250	beta-galactosidase activity
NIAKO_RS21580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIAKO_RS21590	COG4771	TonB-dependent receptor
NIAKO_RS21640	COG0824	Thioesterase
NIAKO_RS21650	COG1058	Belongs to the CinA family
NIAKO_RS21650	COG1546	Belongs to the CinA family
NIAKO_RS21655	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIAKO_RS21675	COG0463	Glycosyl transferase, family 2
NIAKO_RS21685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIAKO_RS21700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS21710	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NIAKO_RS21720	COG0321	lipoyl(octanoyl) transferase activity
NIAKO_RS21725	COG0564	pseudouridine synthase activity
NIAKO_RS21735	COG0242	peptide deformylase activity
NIAKO_RS21740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NIAKO_RS21745	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIAKO_RS21750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIAKO_RS21755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIAKO_RS21770	COG1070	Carbohydrate kinase
NIAKO_RS21775	COG1104	cysteine desulfurase activity
NIAKO_RS21785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIAKO_RS21795	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS21800	COG1253	flavin adenine dinucleotide binding
NIAKO_RS21835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NIAKO_RS21840	COG0505	Belongs to the CarA family
NIAKO_RS21845	COG0203	ribosomal protein L17
NIAKO_RS21850	COG0202	RNA polymerase activity
NIAKO_RS21855	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIAKO_RS21860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NIAKO_RS21865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NIAKO_RS21870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NIAKO_RS21880	COG2814	Major facilitator Superfamily
NIAKO_RS21890	COG1309	transcriptional regulator
NIAKO_RS21905	COG0842	Transport permease protein
NIAKO_RS21910	COG0842	Transport permease protein
NIAKO_RS21915	COG1131	(ABC) transporter
NIAKO_RS21920	COG1131	(ABC) transporter
NIAKO_RS21925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS21940	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NIAKO_RS21990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NIAKO_RS22000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS22015	COG1254	Belongs to the acylphosphatase family
NIAKO_RS22030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIAKO_RS22035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIAKO_RS22040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIAKO_RS22050	COG2010	Cytochrome c
NIAKO_RS22055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NIAKO_RS22055	COG0131	Imidazoleglycerol-phosphate dehydratase
NIAKO_RS22090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NIAKO_RS22095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NIAKO_RS22100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIAKO_RS22110	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NIAKO_RS22115	COG0513	Belongs to the DEAD box helicase family
NIAKO_RS22130	COG1605	Chorismate mutase
NIAKO_RS22130	COG0077	Prephenate dehydratase
NIAKO_RS22145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIAKO_RS22155	COG0793	Belongs to the peptidase S41A family
NIAKO_RS22165	COG1595	DNA-templated transcription, initiation
NIAKO_RS22180	COG2183	response to ionizing radiation
NIAKO_RS22200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIAKO_RS22210	COG1234	tRNA 3'-trailer cleavage
NIAKO_RS22220	COG1830	Aldolase
NIAKO_RS22240	COG0612	Peptidase, M16
NIAKO_RS22250	COG0156	8-amino-7-oxononanoate synthase activity
NIAKO_RS22260	COG4232	protein-disulfide reductase activity
NIAKO_RS22275	COG1674	ftsk spoiiie
NIAKO_RS22280	COG4585	Histidine kinase
NIAKO_RS22285	COG2363	Small membrane protein
NIAKO_RS22290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NIAKO_RS22300	COG1595	DNA-templated transcription, initiation
NIAKO_RS22330	COG4206	TonB-dependent receptor
NIAKO_RS22330	COG1629	transport
NIAKO_RS22355	COG0284	orotidine-5'-phosphate decarboxylase activity
NIAKO_RS22360	COG3844	kynureninase activity
NIAKO_RS22365	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS22370	COG0584	glycerophosphoryl diester phosphodiesterase
NIAKO_RS22375	COG0489	protein tyrosine kinase activity
NIAKO_RS22385	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIAKO_RS22395	COG1739	Uncharacterized protein family UPF0029
NIAKO_RS22400	COG0697	spore germination
NIAKO_RS22405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIAKO_RS22405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIAKO_RS22410	COG2890	protein-(glutamine-N5) methyltransferase activity
NIAKO_RS22430	COG0811	peptide transport
NIAKO_RS22440	COG0492	ferredoxin-NADP+ reductase activity
NIAKO_RS22455	COG2195	Cleaves the N-terminal amino acid of tripeptides
NIAKO_RS22475	COG1047	Peptidyl-prolyl cis-trans
NIAKO_RS22480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NIAKO_RS22490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIAKO_RS22490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NIAKO_RS22515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIAKO_RS22530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NIAKO_RS22600	COG2197	response regulator
NIAKO_RS22610	COG0587	DNA-directed DNA polymerase activity
NIAKO_RS22635	COG1733	regulation of RNA biosynthetic process
NIAKO_RS22655	COG1073	alpha beta
NIAKO_RS22660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS22670	COG4260	virion core protein, lumpy skin disease virus
NIAKO_RS22695	COG3292	Two component regulator propeller
NIAKO_RS22695	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS22695	COG2205	protein histidine kinase activity
NIAKO_RS22735	COG0545	Peptidyl-prolyl cis-trans isomerase
NIAKO_RS22845	COG0412	Dienelactone hydrolase
NIAKO_RS22855	COG4948	Mandelate Racemase Muconate Lactonizing
NIAKO_RS22875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIAKO_RS22880	COG0539	negative regulation of cytoplasmic translation
NIAKO_RS22890	COG2081	HI0933 family
NIAKO_RS22895	COG0024	Methionine aminopeptidase
NIAKO_RS22900	COG0201	protein transport
NIAKO_RS22905	COG0200	Binds to the 23S rRNA
NIAKO_RS22910	COG1841	ribosomal large subunit assembly
NIAKO_RS22915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NIAKO_RS22920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NIAKO_RS22925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NIAKO_RS22930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NIAKO_RS22935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NIAKO_RS22940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIAKO_RS22945	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NIAKO_RS22950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NIAKO_RS22955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NIAKO_RS22960	COG0255	Belongs to the universal ribosomal protein uL29 family
NIAKO_RS22965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NIAKO_RS22970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NIAKO_RS22980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NIAKO_RS22985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIAKO_RS22990	COG0089	rRNA binding
NIAKO_RS22995	COG0088	Forms part of the polypeptide exit tunnel
NIAKO_RS23000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NIAKO_RS23010	COG0051	transcription antitermination factor activity, RNA binding
NIAKO_RS23040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIAKO_RS23060	COG0049	tRNA binding
NIAKO_RS23065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NIAKO_RS23070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIAKO_RS23080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NIAKO_RS23100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NIAKO_RS23105	COG1809	phosphosulfolactate synthase activity
NIAKO_RS23125	COG0706	membrane insertase activity
NIAKO_RS23130	COG0504	CTP synthase activity
NIAKO_RS23135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NIAKO_RS23140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS23145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIAKO_RS23205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NIAKO_RS23210	COG0542	response to heat
NIAKO_RS23245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIAKO_RS23250	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS23270	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS23315	COG2207	Transcriptional regulator
NIAKO_RS23365	COG2433	Pfam Transposase IS66
NIAKO_RS23390	COG4771	TonB-dependent receptor
NIAKO_RS23430	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS23475	COG0432	Pfam Uncharacterised protein family UPF0047
NIAKO_RS23515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS23535	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS23555	COG2176	DNA-directed DNA polymerase activity
NIAKO_RS23565	COG0772	Belongs to the SEDS family
NIAKO_RS23575	COG0631	protein serine/threonine phosphatase activity
NIAKO_RS23620	COG2267	carboxylic ester hydrolase activity
NIAKO_RS23640	COG2072	flavoprotein involved in K transport
NIAKO_RS23645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS23655	COG1201	RNA secondary structure unwinding
NIAKO_RS23665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NIAKO_RS23710	COG0300	oxidoreductase activity
NIAKO_RS23755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS23770	COG2205	protein histidine kinase activity
NIAKO_RS23775	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS23790	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS23795	COG1733	regulation of RNA biosynthetic process
NIAKO_RS23800	COG2267	carboxylic ester hydrolase activity
NIAKO_RS23820	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS23825	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS23830	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS23835	COG1902	pentaerythritol trinitrate reductase activity
NIAKO_RS23845	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS23845	COG3292	Two component regulator propeller
NIAKO_RS23845	COG2205	protein histidine kinase activity
NIAKO_RS23875	COG0656	L-ascorbic acid biosynthetic process
NIAKO_RS23895	COG0110	maltose O-acetyltransferase activity
NIAKO_RS23920	COG1131	(ABC) transporter
NIAKO_RS24035	COG0306	phosphate transporter
NIAKO_RS24055	COG0577	efflux transmembrane transporter activity
NIAKO_RS24065	COG2207	Transcriptional regulator
NIAKO_RS24070	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS24115	COG1793	dna ligase
NIAKO_RS24115	COG3285	dna ligase
NIAKO_RS24125	COG0825	malonyl-CoA metabolic process
NIAKO_RS24130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS24140	COG3001	Fructosamine kinase
NIAKO_RS24150	COG0531	amino acid
NIAKO_RS24160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIAKO_RS24165	COG0085	RNA polymerase activity
NIAKO_RS24170	COG0702	epimerase
NIAKO_RS24175	COG1629	transport
NIAKO_RS24185	COG0222	ribosome binding
NIAKO_RS24190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NIAKO_RS24195	COG0081	regulation of translation
NIAKO_RS24200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NIAKO_RS24265	COG4974	Belongs to the 'phage' integrase family
NIAKO_RS24270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NIAKO_RS24275	COG0307	riboflavin synthase, alpha
NIAKO_RS24320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIAKO_RS24375	COG1595	DNA-templated transcription, initiation
NIAKO_RS24390	COG2133	pyrroloquinoline quinone binding
NIAKO_RS24390	COG5183	chlorophyll binding
NIAKO_RS24445	COG4771	TonB-dependent receptor
NIAKO_RS24505	COG3250	beta-galactosidase activity
NIAKO_RS24520	COG1629	transport
NIAKO_RS24520	COG4206	TonB-dependent receptor
NIAKO_RS24525	COG3292	Two component regulator propeller
NIAKO_RS24525	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS24525	COG3292	Two component regulator propeller
NIAKO_RS24525	COG2205	protein histidine kinase activity
NIAKO_RS24525	COG2205	protein histidine kinase activity
NIAKO_RS24525	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS24530	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS24530	COG2205	protein histidine kinase activity
NIAKO_RS24530	COG3292	Two component regulator propeller
NIAKO_RS24540	COG3408	Glycogen debranching enzyme
NIAKO_RS24620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIAKO_RS24625	COG1629	transport
NIAKO_RS24650	COG1595	DNA-templated transcription, initiation
NIAKO_RS24670	COG1091	dTDP-4-dehydrorhamnose reductase activity
NIAKO_RS24700	COG1519	Transferase
NIAKO_RS24710	COG1435	thymidine kinase activity
NIAKO_RS24720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NIAKO_RS24730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIAKO_RS24745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NIAKO_RS24755	COG0268	Binds directly to 16S ribosomal RNA
NIAKO_RS24760	COG0567	Dehydrogenase, E1 component
NIAKO_RS24765	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIAKO_RS24775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIAKO_RS24775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIAKO_RS24780	COG1404	Belongs to the peptidase S8 family
NIAKO_RS24790	COG0482	sulfurtransferase activity
NIAKO_RS24800	COG0629	single-stranded DNA binding
NIAKO_RS24830	COG0527	aspartate kinase activity
NIAKO_RS24835	COG0657	acetylesterase activity
NIAKO_RS24835	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS24840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIAKO_RS24855	COG4172	Belongs to the ABC transporter superfamily
NIAKO_RS24860	COG2373	Large extracellular alpha-helical protein
NIAKO_RS24865	COG4953	penicillin-binding protein 1C
NIAKO_RS24880	COG0519	Catalyzes the synthesis of GMP from XMP
NIAKO_RS24880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIAKO_RS24895	COG1793	dna ligase
NIAKO_RS24900	COG2010	Cytochrome c
NIAKO_RS24915	COG2197	response regulator
NIAKO_RS24925	COG0415	Belongs to the DNA photolyase family
NIAKO_RS24930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NIAKO_RS24940	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
NIAKO_RS24945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NIAKO_RS24960	COG0302	gtp cyclohydrolase
NIAKO_RS24965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIAKO_RS24980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NIAKO_RS24985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIAKO_RS24990	COG0632	four-way junction helicase activity
NIAKO_RS25005	COG4221	oxidoreductase activity
NIAKO_RS25015	COG2267	carboxylic ester hydrolase activity
NIAKO_RS25025	COG0516	GMP reductase activity
NIAKO_RS25025	COG0517	IMP dehydrogenase activity
NIAKO_RS25040	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIAKO_RS25055	COG2197	response regulator
NIAKO_RS25070	COG4585	Histidine kinase
NIAKO_RS25075	COG2197	response regulator
NIAKO_RS25090	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NIAKO_RS25130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIAKO_RS25130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIAKO_RS25150	COG1538	Outer membrane efflux protein
NIAKO_RS25155	COG0326	Molecular chaperone. Has ATPase activity
NIAKO_RS25175	COG0360	Binds together with S18 to 16S ribosomal RNA
NIAKO_RS25180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NIAKO_RS25185	COG0359	binds to the 23S rRNA
NIAKO_RS25190	COG0724	RNA recognition motif
NIAKO_RS25195	COG0463	Glycosyl transferase, family 2
NIAKO_RS25210	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS25215	COG1477	protein flavinylation
NIAKO_RS25245	COG0101	tRNA pseudouridine synthase activity
NIAKO_RS25255	COG0308	aminopeptidase N
NIAKO_RS25265	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NIAKO_RS25295	COG0126	phosphoglycerate kinase activity
NIAKO_RS25325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NIAKO_RS25330	COG3608	succinylglutamate desuccinylase aspartoacylase
NIAKO_RS25330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NIAKO_RS25395	COG2124	cytochrome p450
NIAKO_RS25450	COG0657	acetylesterase activity
NIAKO_RS25455	COG2345	Transcriptional regulator
NIAKO_RS25485	COG2201	protein-glutamate methylesterase activity
NIAKO_RS25550	COG4977	sequence-specific DNA binding
NIAKO_RS25585	COG0577	efflux transmembrane transporter activity
NIAKO_RS25585	COG1136	(ABC) transporter
NIAKO_RS25625	COG0702	epimerase
NIAKO_RS25630	COG1629	transport
NIAKO_RS25655	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS25660	COG2271	Major facilitator Superfamily
NIAKO_RS25690	COG2186	Transcriptional regulator
NIAKO_RS25700	COG0702	epimerase
NIAKO_RS25705	COG1629	transport
NIAKO_RS25750	COG0702	epimerase
NIAKO_RS25755	COG1629	transport
NIAKO_RS25760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIAKO_RS25780	COG1609	Transcriptional regulator
NIAKO_RS25825	COG1629	transport
NIAKO_RS25855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIAKO_RS25890	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS25895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIAKO_RS25905	COG0019	diaminopimelate decarboxylase activity
NIAKO_RS25915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NIAKO_RS25925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIAKO_RS25935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIAKO_RS25990	COG3685	Protein conserved in bacteria
NIAKO_RS26005	COG2271	Major facilitator Superfamily
NIAKO_RS26010	COG0800	Aldolase
NIAKO_RS26020	COG1904	glucuronate isomerase
NIAKO_RS26025	COG2721	sulfolactate sulfo-lyase activity
NIAKO_RS26030	COG0246	Mannitol dehydrogenase
NIAKO_RS26035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIAKO_RS26045	COG0702	epimerase
NIAKO_RS26050	COG1629	transport
NIAKO_RS26080	COG4677	pectinesterase activity
NIAKO_RS26085	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS26100	COG0702	epimerase
NIAKO_RS26105	COG4771	TonB-dependent receptor
NIAKO_RS26120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIAKO_RS26125	COG0746	molybdenum cofactor guanylyltransferase activity
NIAKO_RS26140	COG0243	molybdopterin cofactor binding
NIAKO_RS26145	COG2223	nitrite transmembrane transporter activity
NIAKO_RS26160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIAKO_RS26165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIAKO_RS26170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIAKO_RS26170	COG1648	precorrin-2 dehydrogenase activity
NIAKO_RS26200	COG1045	serine acetyltransferase
NIAKO_RS26220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIAKO_RS26225	COG0110	maltose O-acetyltransferase activity
NIAKO_RS26235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIAKO_RS26270	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS26320	COG1132	(ABC) transporter
NIAKO_RS26340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NIAKO_RS26350	COG1312	Catalyzes the dehydration of D-mannonate
NIAKO_RS26370	COG2207	Transcriptional regulator
NIAKO_RS26370	COG0662	Cupin 2, conserved barrel domain protein
NIAKO_RS26380	COG2731	YhcH YjgK YiaL family protein
NIAKO_RS26390	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NIAKO_RS26415	COG3250	beta-galactosidase activity
NIAKO_RS26425	COG0702	epimerase
NIAKO_RS26430	COG4771	TonB-dependent receptor
NIAKO_RS26450	COG2954	triphosphatase activity
NIAKO_RS26455	COG0546	phosphoglycolate phosphatase activity
NIAKO_RS26480	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS26505	COG4771	TonB-dependent receptor
NIAKO_RS26525	COG0702	epimerase
NIAKO_RS26530	COG4771	TonB-dependent receptor
NIAKO_RS26540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NIAKO_RS26570	COG0006	proline dipeptidase activity
NIAKO_RS26700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS26740	COG1794	racemase activity, acting on amino acids and derivatives
NIAKO_RS26775	COG1764	response to oxidative stress
NIAKO_RS26790	COG3275	phosphorelay sensor kinase activity
NIAKO_RS26795	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS26805	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS26850	COG0343	queuine tRNA-ribosyltransferase activity
NIAKO_RS26860	COG0357	Ribosomal RNA small subunit methyltransferase G
NIAKO_RS26865	COG2197	response regulator
NIAKO_RS26880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIAKO_RS26895	COG1183	phosphatidylcholine synthase activity
NIAKO_RS26900	COG0006	proline dipeptidase activity
NIAKO_RS26905	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NIAKO_RS26915	COG1428	Deoxynucleoside kinase
NIAKO_RS26920	COG0180	Tryptophanyl-tRNA synthetase
NIAKO_RS26925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIAKO_RS26930	COG1136	(ABC) transporter
NIAKO_RS26935	COG2096	Adenosyltransferase
NIAKO_RS26940	COG1136	(ABC) transporter
NIAKO_RS26950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIAKO_RS26955	COG0497	DNA recombination
NIAKO_RS26970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NIAKO_RS26990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIAKO_RS26995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NIAKO_RS26995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIAKO_RS27040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIAKO_RS27050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NIAKO_RS27065	COG4771	TonB-dependent receptor
NIAKO_RS27070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NIAKO_RS27075	COG0484	heat shock protein binding
NIAKO_RS27080	COG2304	oxidoreductase activity
NIAKO_RS27085	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NIAKO_RS27100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NIAKO_RS27105	COG1611	Belongs to the LOG family
NIAKO_RS27130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NIAKO_RS27160	COG1309	transcriptional regulator
NIAKO_RS27165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIAKO_RS27200	COG3424	synthase
NIAKO_RS27240	COG1090	epimerase
NIAKO_RS27265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NIAKO_RS27270	COG2226	methyltransferase
NIAKO_RS27305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIAKO_RS27310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIAKO_RS27315	COG0308	aminopeptidase N
NIAKO_RS27320	COG0606	chelatase, subunit chli
NIAKO_RS27335	COG0297	glycogen (starch) synthase activity
NIAKO_RS27335	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS27345	COG1216	Glycosyl transferase, family 2
NIAKO_RS27345	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS27350	COG3959	Transketolase, thiamine diphosphate binding domain
NIAKO_RS27355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIAKO_RS27360	COG0463	Glycosyl transferase, family 2
NIAKO_RS27365	COG2813	Specifically methylates the guanine in position
NIAKO_RS27395	COG1442	glycosyl transferase family 8
NIAKO_RS27395	COG1216	Glycosyl transferase, family 2
NIAKO_RS27405	COG1134	teichoic acid transport
NIAKO_RS27405	COG1388	LysM domain
NIAKO_RS27430	COG2244	polysaccharide biosynthetic process
NIAKO_RS27450	COG1132	(ABC) transporter
NIAKO_RS27465	COG3537	Alpha-1,2-mannosidase
NIAKO_RS27470	COG5002	protein histidine kinase activity
NIAKO_RS27495	COG0183	Belongs to the thiolase family
NIAKO_RS27500	COG0167	dihydroorotate dehydrogenase activity
NIAKO_RS27505	COG0861	Integral membrane protein TerC family
NIAKO_RS27515	COG0305	Participates in initiation and elongation during chromosome replication
NIAKO_RS27545	COG1418	mRNA catabolic process
NIAKO_RS27550	COG0335	large ribosomal subunit rRNA binding
NIAKO_RS27555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIAKO_RS27560	COG0154	amidase activity
NIAKO_RS27565	COG1196	nuclear chromosome segregation
NIAKO_RS27565	COG0739	heme binding
NIAKO_RS27565	COG0741	lytic transglycosylase activity
NIAKO_RS27570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIAKO_RS27580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIAKO_RS27585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIAKO_RS27605	COG0544	peptidyl-prolyl cis-trans isomerase activity
NIAKO_RS27615	COG1404	Belongs to the peptidase S8 family
NIAKO_RS27665	COG3239	Fatty acid desaturase
NIAKO_RS27675	COG0084	hydrolase, TatD family'
NIAKO_RS27695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIAKO_RS27710	COG1024	Enoyl-CoA hydratase
NIAKO_RS27715	COG1609	Transcriptional regulator
NIAKO_RS27725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NIAKO_RS27750	COG0316	Belongs to the HesB IscA family
NIAKO_RS27755	COG1104	cysteine desulfurase activity
NIAKO_RS27760	COG0346	lactoylglutathione lyase activity
NIAKO_RS27775	COG0571	ribonuclease III activity
NIAKO_RS27780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIAKO_RS27785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIAKO_RS27790	COG2153	protein acetylation
NIAKO_RS27795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIAKO_RS27810	COG0423	glycine-tRNA ligase activity
NIAKO_RS27820	COG1694	Mazg nucleotide pyrophosphohydrolase
NIAKO_RS27825	COG1490	D-aminoacyl-tRNA deacylase activity
NIAKO_RS27840	COG1858	cytochrome C peroxidase
NIAKO_RS27855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS27925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIAKO_RS27935	COG1162	GTPase activity
NIAKO_RS27955	COG0714	Associated with various cellular activities
NIAKO_RS27970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIAKO_RS27970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIAKO_RS28000	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NIAKO_RS28025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIAKO_RS28035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NIAKO_RS28040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NIAKO_RS28045	COG0165	Argininosuccinate lyase
NIAKO_RS28055	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS28060	COG3275	phosphorelay sensor kinase activity
NIAKO_RS28065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIAKO_RS28075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NIAKO_RS28085	COG1970	mechanosensitive ion channel activity
NIAKO_RS28090	COG2326	polyphosphate kinase activity
NIAKO_RS28095	COG0697	spore germination
NIAKO_RS28100	COG0233	cytoplasmic translational termination
NIAKO_RS28105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIAKO_RS28110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIAKO_RS28120	COG4591	ABC-type transport system involved in lipoprotein release permease component
NIAKO_RS28125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NIAKO_RS28130	COG1132	(ABC) transporter
NIAKO_RS28135	COG1506	peptidase
NIAKO_RS28135	COG0823	Involved in the tonB-independent uptake of proteins
NIAKO_RS28145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NIAKO_RS28155	COG1981	membrane
NIAKO_RS28160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIAKO_RS28165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NIAKO_RS28170	COG0181	hydroxymethylbilane synthase activity
NIAKO_RS28180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NIAKO_RS28185	COG0408	coproporphyrinogen oxidase activity
NIAKO_RS28190	COG0113	porphobilinogen synthase activity
NIAKO_RS28195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIAKO_RS28215	COG0739	heme binding
NIAKO_RS28220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIAKO_RS28225	COG2234	aminopeptidase activity
NIAKO_RS28230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS28235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIAKO_RS28245	COG0702	epimerase
NIAKO_RS28250	COG4206	TonB-dependent receptor
NIAKO_RS28250	COG1629	transport
NIAKO_RS28265	COG1629	transport
NIAKO_RS28280	COG1381	Involved in DNA repair and RecF pathway recombination
NIAKO_RS28285	COG0402	S-adenosylhomocysteine deaminase activity
NIAKO_RS28290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NIAKO_RS28310	COG0509	glycine decarboxylation via glycine cleavage system
NIAKO_RS28315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIAKO_RS28330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NIAKO_RS28370	COG0668	transmembrane transport
NIAKO_RS28380	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIAKO_RS28390	COG1556	Lactate utilization protein
NIAKO_RS28395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIAKO_RS28400	COG0799	negative regulation of ribosome biogenesis
NIAKO_RS28430	COG1940	carbohydrate kinase activity
NIAKO_RS28435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIAKO_RS28450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIAKO_RS28455	COG2197	response regulator
NIAKO_RS28460	COG4585	Histidine kinase
NIAKO_RS28475	COG0658	competence protein
NIAKO_RS28475	COG2333	competence protein COMEC
NIAKO_RS28480	COG0138	bifunctional purine biosynthesis protein purh
NIAKO_RS28510	COG0629	single-stranded DNA binding
NIAKO_RS28520	COG0776	regulation of translation
NIAKO_RS28530	COG1530	ribonuclease E activity
NIAKO_RS28540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIAKO_RS28545	COG1040	competence protein
NIAKO_RS28555	COG0386	Belongs to the glutathione peroxidase family
NIAKO_RS28560	COG0470	DNA polymerase III
NIAKO_RS28565	COG1774	PSP1 C-terminal conserved region
NIAKO_RS28580	COG0612	Peptidase, M16
NIAKO_RS28590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS28600	COG1309	transcriptional regulator
NIAKO_RS28615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NIAKO_RS28630	COG1022	Amp-dependent synthetase and ligase
NIAKO_RS28635	COG0076	glutamate decarboxylase activity
NIAKO_RS28640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIAKO_RS28660	COG2205	protein histidine kinase activity
NIAKO_RS28665	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS28670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NIAKO_RS28695	COG0784	Response regulator, receiver
NIAKO_RS28720	COG2204	response regulator
NIAKO_RS28725	COG4251	negative regulation of phosphorylation
NIAKO_RS28730	COG3852	Histidine kinase
NIAKO_RS28745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIAKO_RS28755	COG1295	ribonuclease BN
NIAKO_RS28755	COG1959	2 iron, 2 sulfur cluster binding
NIAKO_RS28790	COG3685	Protein conserved in bacteria
NIAKO_RS28850	COG1116	anion transmembrane transporter activity
NIAKO_RS28875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIAKO_RS28890	COG2080	2 iron, 2 sulfur cluster binding
NIAKO_RS28895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIAKO_RS28895	COG2010	Cytochrome c
NIAKO_RS28910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIAKO_RS28915	COG1397	ADP-ribosylglycohydrolase
NIAKO_RS28920	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NIAKO_RS28990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
NIAKO_RS28995	COG2425	protein containing a von Willebrand factor type A (vWA) domain
NIAKO_RS29000	COG0714	Associated with various cellular activities
NIAKO_RS29050	COG0783	Belongs to the Dps family
NIAKO_RS29100	COG2169	Transcriptional regulator
NIAKO_RS29110	COG0640	Transcriptional regulator
NIAKO_RS29160	COG2197	response regulator
NIAKO_RS29170	COG0511	ligase activity, forming carbon-carbon bonds
NIAKO_RS29170	COG5016	pyruvate
NIAKO_RS29175	COG0439	Biotin carboxylase
NIAKO_RS29180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NIAKO_RS29220	COG3541	Predicted nucleotidyltransferase
NIAKO_RS29255	COG0702	epimerase
NIAKO_RS29260	COG1629	transport
NIAKO_RS29300	COG4221	oxidoreductase activity
NIAKO_RS29320	COG3275	phosphorelay sensor kinase activity
NIAKO_RS29325	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS29360	COG0784	Response regulator, receiver
NIAKO_RS29370	COG4251	negative regulation of phosphorylation
NIAKO_RS29580	COG4974	Belongs to the 'phage' integrase family
NIAKO_RS29615	COG2204	response regulator
NIAKO_RS29630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NIAKO_RS29635	COG1410	methionine synthase
NIAKO_RS29635	COG0646	methionine synthase
NIAKO_RS29650	COG1611	Belongs to the LOG family
NIAKO_RS29655	COG0708	Exodeoxyribonuclease III
NIAKO_RS29670	COG0259	pyridoxamine-phosphate oxidase activity
NIAKO_RS29685	COG0528	UMP kinase activity
NIAKO_RS29690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIAKO_RS29695	COG0052	Belongs to the universal ribosomal protein uS2 family
NIAKO_RS29700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NIAKO_RS29705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NIAKO_RS29710	COG2304	oxidoreductase activity
NIAKO_RS29715	COG3344	reverse transcriptase
NIAKO_RS29755	COG4771	TonB-dependent receptor
NIAKO_RS29765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIAKO_RS29780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NIAKO_RS29795	COG1309	transcriptional regulator
NIAKO_RS29800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIAKO_RS29835	COG4942	peptidase
NIAKO_RS29865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NIAKO_RS29865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIAKO_RS29870	COG0215	cysteine-tRNA ligase activity
NIAKO_RS29890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIAKO_RS29895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIAKO_RS29900	COG0563	adenylate kinase activity
NIAKO_RS29905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS29920	COG2030	dehydratase
NIAKO_RS29920	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS29940	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS29950	COG1137	ATPase activity
NIAKO_RS29965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIAKO_RS29975	COG0436	Aminotransferase
NIAKO_RS29985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIAKO_RS30010	COG4585	Histidine kinase
NIAKO_RS30010	COG2203	Gaf domain
NIAKO_RS30015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIAKO_RS30020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NIAKO_RS30025	COG0195	Participates in both transcription termination and antitermination
NIAKO_RS30030	COG0779	Required for maturation of 30S ribosomal subunits
NIAKO_RS30040	COG1011	Hydrolase
NIAKO_RS30065	COG1629	transport
NIAKO_RS30090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NIAKO_RS30170	COG0582	viral genome integration into host DNA
NIAKO_RS30260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS30265	COG0827	DNA restriction-modification system
NIAKO_RS30280	COG0251	oxidation-reduction process
NIAKO_RS30380	COG1629	transport
NIAKO_RS30395	COG0702	epimerase
NIAKO_RS30400	COG1629	transport
NIAKO_RS30485	COG1252	NADH dehydrogenase
NIAKO_RS30495	COG3591	Belongs to the peptidase S1B family
NIAKO_RS30505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NIAKO_RS30520	COG0667	Aldo Keto reductase
NIAKO_RS30525	COG2050	protein possibly involved in aromatic compounds catabolism
NIAKO_RS30530	COG1024	Enoyl-CoA hydratase
NIAKO_RS30535	COG2151	metal-sulfur cluster biosynthetic enzyme
NIAKO_RS30540	COG3396	Phenylacetate-CoA oxygenase
NIAKO_RS30545	COG3460	Phenylacetate-CoA oxygenase
NIAKO_RS30550	COG3396	Phenylacetate-CoA oxygenase
NIAKO_RS30580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIAKO_RS30595	COG2972	Histidine kinase
NIAKO_RS30600	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS30625	COG1127	ABC transporter
NIAKO_RS30630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIAKO_RS30635	COG1404	Belongs to the peptidase S8 family
NIAKO_RS30665	COG0824	Thioesterase
NIAKO_RS30680	COG0628	permease
NIAKO_RS30710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIAKO_RS30715	COG1649	PFAM Uncharacterised BCR, COG1649
NIAKO_RS30720	COG1846	Transcriptional regulator
NIAKO_RS30735	COG3757	hydrolase, family 25
NIAKO_RS30780	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS30790	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS30800	COG4654	Cytochrome c, class I
NIAKO_RS30865	COG2972	Histidine kinase
NIAKO_RS30870	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS30895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIAKO_RS30900	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS30910	COG2321	neutral zinc metallopeptidase
NIAKO_RS30930	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NIAKO_RS30945	COG0556	nucleotide-excision repair
NIAKO_RS30950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIAKO_RS30950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIAKO_RS30995	COG3275	phosphorelay sensor kinase activity
NIAKO_RS31000	COG2204	response regulator
NIAKO_RS31030	COG1999	signal sequence binding
NIAKO_RS31040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NIAKO_RS31050	COG0300	oxidoreductase activity
NIAKO_RS31105	COG0483	inositol monophosphate 1-phosphatase activity
NIAKO_RS31110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIAKO_RS31120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NIAKO_RS31125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIAKO_RS31175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NIAKO_RS31185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NIAKO_RS31195	COG0445	tRNA wobble uridine modification
NIAKO_RS31205	COG1956	GAF domain-containing protein
NIAKO_RS31210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIAKO_RS31230	COG1271	oxidase subunit
NIAKO_RS31235	COG1294	oxidase, subunit
NIAKO_RS31245	COG0598	Magnesium transport protein CorA
NIAKO_RS31255	COG1454	alcohol dehydrogenase
NIAKO_RS31260	COG1621	beta-fructofuranosidase activity
NIAKO_RS31270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS31275	COG1940	carbohydrate kinase activity
NIAKO_RS31280	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NIAKO_RS31285	COG2308	Evidence 4 Homologs of previously reported genes of
NIAKO_RS31295	COG1305	Transglutaminase-like
NIAKO_RS31315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIAKO_RS31325	COG4251	negative regulation of phosphorylation
NIAKO_RS31335	COG1289	transmembrane transporter activity
NIAKO_RS31365	COG0697	spore germination
NIAKO_RS31370	COG1522	sequence-specific DNA binding
NIAKO_RS31415	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS31420	COG5002	protein histidine kinase activity
NIAKO_RS31430	COG3781	membrane
NIAKO_RS31435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIAKO_RS31450	COG1629	transport
NIAKO_RS31455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NIAKO_RS31460	COG1501	Belongs to the glycosyl hydrolase 31 family
NIAKO_RS31525	COG0514	ATP-dependent DNA helicase (RecQ)
NIAKO_RS31545	COG2315	Protein conserved in bacteria
NIAKO_RS31550	COG0436	Aminotransferase
NIAKO_RS31555	COG1247	-acetyltransferase
NIAKO_RS31565	COG1082	Xylose isomerase domain protein TIM barrel
NIAKO_RS31570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIAKO_RS31575	COG0017	Asparaginyl-tRNA synthetase
NIAKO_RS31625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIAKO_RS31635	COG2045	Belongs to the ComB family
NIAKO_RS31645	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NIAKO_RS31650	COG2154	pterin-4-alpha-carbinolamine dehydratase
NIAKO_RS31665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIAKO_RS31685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIAKO_RS31720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIAKO_RS31730	COG0612	Peptidase, M16
NIAKO_RS31735	COG0612	Peptidase, M16
NIAKO_RS31740	COG1950	PFAM Membrane protein of
NIAKO_RS31745	COG0022	dehydrogenase e1 component
NIAKO_RS31755	COG0793	Belongs to the peptidase S41A family
NIAKO_RS31770	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
NIAKO_RS31780	COG3237	CsbD-like
NIAKO_RS31795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIAKO_RS31820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIAKO_RS31830	COG0437	4 iron, 4 sulfur cluster binding
NIAKO_RS31860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIAKO_RS31865	COG0109	protoheme IX farnesyltransferase activity
NIAKO_RS31875	COG1845	cytochrome c oxidase, subunit III
NIAKO_RS31890	COG2322	membrane
NIAKO_RS31900	COG1063	alcohol dehydrogenase
NIAKO_RS31915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIAKO_RS31920	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS31930	COG1522	sequence-specific DNA binding
NIAKO_RS31940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIAKO_RS31945	COG1215	transferase activity, transferring glycosyl groups
NIAKO_RS31950	COG0596	Alpha beta hydrolase
NIAKO_RS31960	COG1960	acyl-CoA dehydrogenase activity
NIAKO_RS31970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NIAKO_RS31980	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
NIAKO_RS31990	COG0463	Glycosyl transferase, family 2
NIAKO_RS31995	COG0363	glucosamine-6-phosphate deaminase activity
NIAKO_RS32000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIAKO_RS32005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIAKO_RS32015	COG0724	RNA recognition motif
NIAKO_RS32035	COG0739	heme binding
NIAKO_RS32045	COG0823	Involved in the tonB-independent uptake of proteins
NIAKO_RS32050	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIAKO_RS32060	COG0009	L-threonylcarbamoyladenylate synthase
NIAKO_RS32070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NIAKO_RS32085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS32085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIAKO_RS32105	COG3258	Cytochrome c
NIAKO_RS32115	COG1612	heme a metabolic process
NIAKO_RS32145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIAKO_RS32170	COG1217	gtp-binding protein TYPA
NIAKO_RS32190	COG0463	Glycosyl transferase, family 2
NIAKO_RS32205	COG1703	isobutyryl-CoA mutase activity
NIAKO_RS32220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NIAKO_RS32230	COG0667	Aldo Keto reductase
NIAKO_RS32245	COG1309	transcriptional regulator
NIAKO_RS32260	COG2814	Major facilitator Superfamily
NIAKO_RS32265	COG0300	oxidoreductase activity
NIAKO_RS32270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NIAKO_RS32275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIAKO_RS32290	COG5297	Belongs to the glycosyl hydrolase family 6
NIAKO_RS32290	COG3250	beta-galactosidase activity
NIAKO_RS32325	COG0626	cystathionine gamma-synthase activity
NIAKO_RS32335	COG0367	asparagine synthase
NIAKO_RS32365	COG1368	sulfuric ester hydrolase activity
NIAKO_RS32370	COG0698	ribose 5-phosphate isomerase
NIAKO_RS32375	COG0805	protein transport
NIAKO_RS32385	COG0194	GDP metabolic process
NIAKO_RS32390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NIAKO_RS32405	COG1610	YqeY-like protein
NIAKO_RS32415	COG0596	Alpha beta hydrolase
NIAKO_RS32430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIAKO_RS32440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIAKO_RS32460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIAKO_RS32465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NIAKO_RS32470	COG0594	ribonuclease P activity
NIAKO_RS32505	COG1629	transport
NIAKO_RS32520	COG2610	gluconate transmembrane transporter activity
NIAKO_RS32530	COG1012	belongs to the aldehyde dehydrogenase family
NIAKO_RS32535	COG0386	Belongs to the glutathione peroxidase family
NIAKO_RS32565	COG4589	Belongs to the CDS family
NIAKO_RS32575	COG0688	phosphatidylethanolamine metabolic process
NIAKO_RS32600	COG2205	protein histidine kinase activity
NIAKO_RS32615	COG1187	pseudouridine synthase activity
NIAKO_RS32620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIAKO_RS32625	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS32630	COG3275	phosphorelay sensor kinase activity
NIAKO_RS32640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS32645	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIAKO_RS32650	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NIAKO_RS32675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NIAKO_RS32680	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS32690	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIAKO_RS32690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIAKO_RS32720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIAKO_RS32735	COG0148	phosphopyruvate hydratase activity
NIAKO_RS32745	COG1131	(ABC) transporter
NIAKO_RS32750	COG0288	reversible hydration of carbon dioxide
NIAKO_RS32755	COG0659	secondary active sulfate transmembrane transporter activity
NIAKO_RS32775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIAKO_RS32800	COG1595	DNA-templated transcription, initiation
NIAKO_RS32810	COG0156	8-amino-7-oxononanoate synthase activity
NIAKO_RS32835	COG1214	PFAM Peptidase M22, glycoprotease
NIAKO_RS32840	COG0640	Transcriptional regulator
NIAKO_RS32845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS32845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIAKO_RS32850	COG2197	response regulator
NIAKO_RS32860	COG1660	Displays ATPase and GTPase activities
NIAKO_RS32875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NIAKO_RS32890	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NIAKO_RS32900	COG2318	DinB family
NIAKO_RS32905	COG2378	regulation of single-species biofilm formation
NIAKO_RS32910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NIAKO_RS32920	COG2304	oxidoreductase activity
NIAKO_RS32960	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS32970	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS32975	COG3618	amidohydrolase
NIAKO_RS32980	COG3254	rhamnose metabolic process
NIAKO_RS32985	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIAKO_RS32990	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS32990	COG1703	isobutyryl-CoA mutase activity
NIAKO_RS32990	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS32995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS32995	COG1703	isobutyryl-CoA mutase activity
NIAKO_RS32995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
NIAKO_RS33005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIAKO_RS33010	COG1136	(ABC) transporter
NIAKO_RS33015	COG1136	(ABC) transporter
NIAKO_RS33015	COG0577	efflux transmembrane transporter activity
NIAKO_RS33030	COG0513	Belongs to the DEAD box helicase family
NIAKO_RS33065	COG1595	DNA-templated transcription, initiation
NIAKO_RS33075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIAKO_RS33120	COG2197	response regulator
NIAKO_RS33180	COG1690	Belongs to the RtcB family
NIAKO_RS33220	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS33260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS33290	COG1086	Polysaccharide biosynthesis protein
NIAKO_RS33305	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS33345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS33350	COG0667	Aldo Keto reductase
NIAKO_RS33360	COG0297	glycogen (starch) synthase activity
NIAKO_RS33370	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIAKO_RS33385	COG2192	nodulation
NIAKO_RS33395	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIAKO_RS33400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS33405	COG4464	protein tyrosine phosphatase activity
NIAKO_RS33415	COG1595	DNA-templated transcription, initiation
NIAKO_RS33420	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
NIAKO_RS33455	COG0277	FAD linked oxidase domain protein
NIAKO_RS33455	COG0247	lactate metabolic process
NIAKO_RS33465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NIAKO_RS33465	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS33470	COG3275	phosphorelay sensor kinase activity
NIAKO_RS33475	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS33495	COG1522	sequence-specific DNA binding
NIAKO_RS33505	COG0300	oxidoreductase activity
NIAKO_RS33545	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS33565	COG1942	4-Oxalocrotonate Tautomerase
NIAKO_RS33570	COG1028	Short-chain dehydrogenase reductase Sdr
NIAKO_RS33580	COG2070	2-Nitropropane dioxygenase
NIAKO_RS33585	COG4221	oxidoreductase activity
NIAKO_RS33655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NIAKO_RS33660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NIAKO_RS33690	COG4772	TonB-dependent receptor
NIAKO_RS33695	COG0531	amino acid
NIAKO_RS33700	COG0626	cystathionine gamma-synthase activity
NIAKO_RS33715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NIAKO_RS33720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIAKO_RS33740	COG1331	Highly conserved protein containing a thioredoxin domain
NIAKO_RS33745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS33765	COG0322	excinuclease ABC activity
NIAKO_RS33785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIAKO_RS33790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIAKO_RS33805	COG0023	Translation Initiation Factor
NIAKO_RS33815	COG0473	3-isopropylmalate dehydrogenase activity
NIAKO_RS33820	COG2967	ApaG domain
NIAKO_RS33825	COG3104	oligopeptide transport
NIAKO_RS33830	COG0151	Belongs to the GarS family
NIAKO_RS33835	COG3483	tryptophan 2,3-dioxygenase activity
NIAKO_RS33840	COG1077	Cell shape determining protein MreB Mrl
NIAKO_RS33860	COG0772	Belongs to the SEDS family
NIAKO_RS33880	COG1191	sigma factor activity
NIAKO_RS33895	COG3958	Transketolase
NIAKO_RS33910	COG0306	phosphate transporter
NIAKO_RS33960	COG5002	protein histidine kinase activity
NIAKO_RS33965	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS33980	COG1132	(ABC) transporter
NIAKO_RS33985	COG0356	it plays a direct role in the translocation of protons across the membrane
NIAKO_RS33990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIAKO_RS33995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NIAKO_RS34000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIAKO_RS34005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NIAKO_RS34060	COG1131	(ABC) transporter
NIAKO_RS34075	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS34080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS34085	COG3622	Belongs to the hyi family
NIAKO_RS34095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIAKO_RS34105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIAKO_RS34110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIAKO_RS34115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NIAKO_RS34125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIAKO_RS34140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIAKO_RS34145	COG2270	Major facilitator Superfamily
NIAKO_RS34150	COG1968	undecaprenyl-diphosphatase activity
NIAKO_RS34160	COG2177	Part of the ABC transporter FtsEX involved in
NIAKO_RS34165	COG0495	leucyl-tRNA aminoacylation
NIAKO_RS34200	COG2255	four-way junction helicase activity
NIAKO_RS34215	COG0433	COG0433 Predicted ATPase
NIAKO_RS34225	COG0514	ATP-dependent DNA helicase (RecQ)
NIAKO_RS34230	COG2217	Heavy metal translocating P-type atpase
NIAKO_RS34255	COG1131	(ABC) transporter
NIAKO_RS34260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIAKO_RS34265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NIAKO_RS34265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIAKO_RS34270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIAKO_RS34275	COG1078	dGTPase activity
NIAKO_RS34280	COG2204	response regulator
NIAKO_RS34290	COG1234	tRNA 3'-trailer cleavage
NIAKO_RS34295	COG0784	Response regulator, receiver
NIAKO_RS34295	COG2198	Histidine kinase
NIAKO_RS34295	COG5002	protein histidine kinase activity
NIAKO_RS34310	COG1960	acyl-CoA dehydrogenase activity
NIAKO_RS34320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIAKO_RS34330	COG0740	serine-type endopeptidase activity
NIAKO_RS34335	COG0175	sulfate reduction
NIAKO_RS34340	COG0175	sulfate reduction
NIAKO_RS34350	COG1045	serine acetyltransferase
NIAKO_RS34360	COG1648	precorrin-2 dehydrogenase activity
NIAKO_RS34360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIAKO_RS34365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIAKO_RS34375	COG1648	precorrin-2 dehydrogenase activity
NIAKO_RS34375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIAKO_RS34400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIAKO_RS34405	COG1765	OsmC-like protein
NIAKO_RS34420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIAKO_RS34425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS34440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NIAKO_RS34445	COG0756	dUTP diphosphatase activity
NIAKO_RS34465	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS34480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIAKO_RS34490	COG2094	Belongs to the DNA glycosylase MPG family
NIAKO_RS34500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NIAKO_RS34505	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NIAKO_RS34510	COG2234	aminopeptidase activity
NIAKO_RS34525	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS34530	COG3275	phosphorelay sensor kinase activity
NIAKO_RS34555	COG1233	COG1233 Phytoene dehydrogenase and related
NIAKO_RS34575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NIAKO_RS34585	COG1501	Belongs to the glycosyl hydrolase 31 family
NIAKO_RS34590	COG0336	Belongs to the RNA methyltransferase TrmD family
NIAKO_RS34595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NIAKO_RS34600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NIAKO_RS34605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NIAKO_RS34625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIAKO_RS34630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIAKO_RS34635	COG0228	four-way junction DNA binding
NIAKO_RS34640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NIAKO_RS34655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIAKO_RS34660	COG0450	alkyl hydroperoxide reductase
NIAKO_RS34675	COG0564	pseudouridine synthase activity
NIAKO_RS34680	COG1187	pseudouridine synthase activity
NIAKO_RS34690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIAKO_RS34705	COG0183	Belongs to the thiolase family
NIAKO_RS34725	COG0577	efflux transmembrane transporter activity
NIAKO_RS34725	COG1136	(ABC) transporter
NIAKO_RS34735	COG0124	histidyl-tRNA synthetase
NIAKO_RS34740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIAKO_RS34760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS34765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS34770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS34775	COG0649	NAD binding
NIAKO_RS34780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NIAKO_RS34790	COG1034	ATP synthesis coupled electron transport
NIAKO_RS34795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIAKO_RS34800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS34805	COG0839	Belongs to the complex I subunit 6 family
NIAKO_RS34810	COG0713	ATP synthesis coupled electron transport
NIAKO_RS34815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIAKO_RS34825	COG1007	ATP synthesis coupled electron transport
NIAKO_RS34830	COG0577	efflux transmembrane transporter activity
NIAKO_RS34830	COG1136	(ABC) transporter
NIAKO_RS34870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIAKO_RS34875	COG3459	Glycosyltransferase 36 associated
NIAKO_RS34880	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS34880	COG2205	protein histidine kinase activity
NIAKO_RS34880	COG3292	Two component regulator propeller
NIAKO_RS34930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIAKO_RS34955	COG0438	transferase activity, transferring glycosyl groups
NIAKO_RS34955	COG0297	glycogen (starch) synthase activity
NIAKO_RS35015	COG0598	Magnesium transport protein CorA
NIAKO_RS35020	COG1132	(ABC) transporter
NIAKO_RS35080	COG0584	glycerophosphoryl diester phosphodiesterase
NIAKO_RS35090	COG1629	transport
NIAKO_RS35110	COG1301	dicarboxylic acid transport
NIAKO_RS35130	COG1253	flavin adenine dinucleotide binding
NIAKO_RS35135	COG1595	DNA-templated transcription, initiation
NIAKO_RS35165	COG1629	transport
NIAKO_RS35170	COG0561	phosphatase activity
NIAKO_RS35215	COG0668	transmembrane transport
NIAKO_RS35270	COG0659	secondary active sulfate transmembrane transporter activity
NIAKO_RS35280	COG1629	transport
NIAKO_RS35345	COG1715	Restriction endonuclease
NIAKO_RS35360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIAKO_RS35450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIAKO_RS35460	COG2755	lipolytic protein G-D-S-L family
NIAKO_RS35460	COG0657	acetylesterase activity
NIAKO_RS35465	COG2169	Transcriptional regulator
NIAKO_RS35470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIAKO_RS35480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NIAKO_RS35485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS35490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS35495	COG0649	NAD binding
NIAKO_RS35500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS35500	COG0649	NAD binding
NIAKO_RS35505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIAKO_RS35510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS35515	COG0839	Belongs to the complex I subunit 6 family
NIAKO_RS35525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIAKO_RS35530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIAKO_RS35560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NIAKO_RS35565	COG0673	inositol 2-dehydrogenase activity
NIAKO_RS35575	COG3279	Response regulator of the LytR AlgR family
NIAKO_RS35595	COG5002	protein histidine kinase activity
NIAKO_RS35600	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS35610	COG0251	oxidation-reduction process
NIAKO_RS35615	COG1921	L-seryl-tRNASec selenium transferase activity
NIAKO_RS35620	COG3964	amidohydrolase
NIAKO_RS35635	COG1733	regulation of RNA biosynthetic process
NIAKO_RS35640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NIAKO_RS35645	COG2353	YceI-like domain
NIAKO_RS35650	COG2353	YceI-like domain
NIAKO_RS35665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIAKO_RS35695	COG1629	transport
NIAKO_RS35695	COG4206	TonB-dependent receptor
NIAKO_RS35710	COG1349	DNA-binding transcription factor activity
NIAKO_RS35715	COG1629	transport
NIAKO_RS35715	COG4206	TonB-dependent receptor
NIAKO_RS35730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NIAKO_RS35735	COG2610	gluconate transmembrane transporter activity
NIAKO_RS35765	COG1595	DNA-templated transcription, initiation
NIAKO_RS35775	COG4206	TonB-dependent receptor
NIAKO_RS35775	COG1629	transport
NIAKO_RS35800	COG1472	Belongs to the glycosyl hydrolase 3 family
NIAKO_RS35810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIAKO_RS35810	COG0515	serine threonine protein kinase
NIAKO_RS35815	COG1629	transport
NIAKO_RS35815	COG4206	TonB-dependent receptor
NIAKO_RS35855	COG1609	Transcriptional regulator
NIAKO_RS35865	COG4771	TonB-dependent receptor
NIAKO_RS35870	COG0702	epimerase
NIAKO_RS35890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NIAKO_RS35895	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIAKO_RS35910	COG0667	Aldo Keto reductase
NIAKO_RS35915	COG3250	beta-galactosidase activity
NIAKO_RS35920	COG0667	Aldo Keto reductase
NIAKO_RS35945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIAKO_RS35960	COG1678	Uncharacterized ACR, COG1678
NIAKO_RS35985	COG2001	Belongs to the MraZ family
NIAKO_RS35990	COG0275	rRNA processing
NIAKO_RS36000	COG0768	penicillin binding
NIAKO_RS36005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIAKO_RS36010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIAKO_RS36015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NIAKO_RS36025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIAKO_RS36030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIAKO_RS36045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIAKO_RS36050	COG1090	epimerase
NIAKO_RS36060	COG1131	(ABC) transporter
NIAKO_RS36070	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIAKO_RS36070	COG1024	Enoyl-CoA hydratase
NIAKO_RS36075	COG2379	hydroxypyruvate reductase
NIAKO_RS36080	COG2084	Dehydrogenase
NIAKO_RS36085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIAKO_RS36085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIAKO_RS36110	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIAKO_RS36115	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIAKO_RS36140	COG3158	transport of potassium into the cell
NIAKO_RS36155	COG0047	phosphoribosylformylglycinamidine synthase activity
NIAKO_RS36200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NIAKO_RS36230	COG4152	abc transporter atp-binding protein
NIAKO_RS36240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NIAKO_RS36275	COG4251	negative regulation of phosphorylation
NIAKO_RS36285	COG0840	transmembrane signaling receptor activity
NIAKO_RS36290	COG2972	Histidine kinase
NIAKO_RS36325	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NIAKO_RS36330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS36335	COG3291	Pkd domain containing protein
NIAKO_RS36355	COG3469	chitinase activity
NIAKO_RS36355	COG3325	Belongs to the glycosyl hydrolase 18 family
NIAKO_RS36365	COG3275	phosphorelay sensor kinase activity
NIAKO_RS36395	COG0791	NLP P60 protein
NIAKO_RS36405	COG4977	sequence-specific DNA binding
NIAKO_RS36405	COG1917	Cupin 2, conserved barrel domain protein
NIAKO_RS36415	COG3850	Histidine kinase
NIAKO_RS36415	COG4999	Histidine kinase
NIAKO_RS36415	COG2205	protein histidine kinase activity
NIAKO_RS36415	COG3437	response regulator, receiver
NIAKO_RS36440	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIAKO_RS36480	COG2885	chlorophyll binding
NIAKO_RS36525	COG0671	phosphoesterase, PA-phosphatase related
NIAKO_RS36560	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS36565	COG2201	protein-glutamate methylesterase activity
NIAKO_RS36570	COG2205	protein histidine kinase activity
NIAKO_RS36580	COG2989	Protein conserved in bacteria
NIAKO_RS36595	COG3275	phosphorelay sensor kinase activity
NIAKO_RS36615	COG2192	nodulation
NIAKO_RS36620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS36625	COG0784	Response regulator, receiver
NIAKO_RS36625	COG0835	chemotaxis
NIAKO_RS36630	COG2205	protein histidine kinase activity
NIAKO_RS36645	COG2972	Histidine kinase
NIAKO_RS36660	COG3275	phosphorelay sensor kinase activity
NIAKO_RS36665	COG3209	COG3209 Rhs family protein
NIAKO_RS36670	COG4251	negative regulation of phosphorylation
NIAKO_RS36695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS36770	COG5492	domain, Protein
NIAKO_RS36775	COG0463	Glycosyl transferase, family 2
NIAKO_RS36775	COG1216	Glycosyl transferase, family 2
NIAKO_RS36785	COG1216	Glycosyl transferase, family 2
NIAKO_RS36805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS36815	COG3275	phosphorelay sensor kinase activity
NIAKO_RS36820	COG3275	phosphorelay sensor kinase activity
NIAKO_RS36870	COG3547	Transposase (IS116 IS110 IS902 family)
NIAKO_RS36885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS36895	COG0784	Response regulator, receiver
NIAKO_RS36915	COG2267	carboxylic ester hydrolase activity
NIAKO_RS36920	COG5002	protein histidine kinase activity
NIAKO_RS36920	COG2205	protein histidine kinase activity
NIAKO_RS36920	COG0784	Response regulator, receiver
NIAKO_RS36940	COG4206	TonB-dependent receptor
NIAKO_RS36940	COG1629	transport
NIAKO_RS36950	COG0745	RESPONSE REGULATOR receiver
NIAKO_RS36970	COG5002	protein histidine kinase activity
NIAKO_RS36990	COG1733	regulation of RNA biosynthetic process
NIAKO_RS37000	COG5002	protein histidine kinase activity
NIAKO_RS37000	COG3850	Histidine kinase
NIAKO_RS37025	COG1216	Glycosyl transferase, family 2
NIAKO_RS37025	COG0463	Glycosyl transferase, family 2
NIAKO_RS37035	COG0484	heat shock protein binding
NIAKO_RS37095	COG2226	methyltransferase
NIAKO_RS37110	COG3275	phosphorelay sensor kinase activity
NIAKO_RS37115	COG2815	serine threonine protein kinase
NIAKO_RS37115	COG0515	serine threonine protein kinase
NIAKO_RS37140	COG4946	Tricorn protease homolog
NIAKO_RS37140	COG1506	peptidase
NIAKO_RS37140	COG0823	Involved in the tonB-independent uptake of proteins
NIAKO_RS37170	COG4251	negative regulation of phosphorylation
NIAKO_RS37180	COG2885	chlorophyll binding
NIAKO_RS37185	COG2205	protein histidine kinase activity
NIAKO_RS37185	COG0784	Response regulator, receiver
NIAKO_RS37195	COG1247	-acetyltransferase
NIAKO_RS37230	COG0514	ATP-dependent DNA helicase (RecQ)
NIAKO_RS37240	COG1388	LysM domain
NIAKO_RS37240	COG1705	Flagellar rod assembly protein muramidase FlgJ
NIAKO_RS37275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIAKO_RS37285	COG4251	negative regulation of phosphorylation
NIAKO_RS37295	COG2885	chlorophyll binding
NIAKO_RS37310	COG1649	PFAM Uncharacterised BCR, COG1649
NIAKO_RS37335	COG1396	sequence-specific DNA binding
NIAKO_RS37375	COG1215	transferase activity, transferring glycosyl groups
NIAKO_RS37390	COG2205	protein histidine kinase activity
NIAKO_RS37390	COG3437	response regulator, receiver
NIAKO_RS37390	COG3850	Histidine kinase
NIAKO_RS37390	COG4999	Histidine kinase
NIAKO_RS37395	COG3548	integral membrane protein
NIAKO_RS37430	COG1215	transferase activity, transferring glycosyl groups
NIAKO_RS37440	COG2972	Histidine kinase
NIAKO_RS37460	COG4251	negative regulation of phosphorylation
NIAKO_RS37480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIAKO_RS37505	COG0657	acetylesterase activity
NIAKO_RS37505	COG2755	lipolytic protein G-D-S-L family