locus-tag	class	description
JG738_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JG738_RS00010	COG0592	DNA-directed DNA polymerase activity
JG738_RS00015	COG0187	DNA topoisomerase II activity
JG738_RS00020	COG5001	Diguanylate cyclase
JG738_RS00020	COG5002	protein histidine kinase activity
JG738_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JG738_RS00035	COG1053	succinate dehydrogenase
JG738_RS00040	COG0531	amino acid
JG738_RS00075	COG0450	alkyl hydroperoxide reductase
JG738_RS00135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JG738_RS00145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JG738_RS00155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JG738_RS00170	COG0300	oxidoreductase activity
JG738_RS00175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JG738_RS00180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JG738_RS00185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JG738_RS00190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JG738_RS00195	COG0564	pseudouridine synthase activity
JG738_RS00200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JG738_RS00205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JG738_RS00215	COG0107	imidazoleglycerol-phosphate synthase activity
JG738_RS00220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JG738_RS00225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JG738_RS00230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JG738_RS00235	COG0517	IMP dehydrogenase activity
JG738_RS00235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JG738_RS00240	COG1187	pseudouridine synthase activity
JG738_RS00245	COG0432	Pfam Uncharacterised protein family UPF0047
JG738_RS00250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JG738_RS00250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JG738_RS00275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JG738_RS00290	COG1959	2 iron, 2 sulfur cluster binding
JG738_RS00300	COG0004	ammonium transporteR
JG738_RS00330	COG1490	D-aminoacyl-tRNA deacylase activity
JG738_RS00360	COG0237	dephospho-CoA kinase activity
JG738_RS00365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JG738_RS00375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JG738_RS00380	COG0268	Binds directly to 16S ribosomal RNA
JG738_RS00385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JG738_RS00390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JG738_RS00405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JG738_RS00410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JG738_RS00415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JG738_RS00440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JG738_RS00515	COG0531	amino acid
JG738_RS00535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JG738_RS00550	COG0730	response to heat
JG738_RS00585	COG1017	nitric oxide dioxygenase activity
JG738_RS00585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JG738_RS00590	COG0543	2 iron, 2 sulfur cluster binding
JG738_RS00590	COG0633	Ferredoxin
JG738_RS00605	COG4232	protein-disulfide reductase activity
JG738_RS00645	COG0179	Fumarylacetoacetate (FAA) hydrolase
JG738_RS00650	COG0840	transmembrane signaling receptor activity
JG738_RS00655	COG1162	GTPase activity
JG738_RS00660	COG0129	dihydroxy-acid dehydratase activity
JG738_RS00700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JG738_RS00710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JG738_RS00720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JG738_RS00725	COG2226	methyltransferase
JG738_RS00735	COG2132	Multicopper oxidase
JG738_RS00745	COG1704	LemA family
JG738_RS00780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JG738_RS00800	COG0667	Aldo Keto reductase
JG738_RS00810	COG0348	domain, Protein
JG738_RS00860	COG3842	ATPase activity
JG738_RS00870	COG3300	MHYT domain
JG738_RS00870	COG5001	Diguanylate cyclase
JG738_RS00885	COG0504	CTP synthase activity
JG738_RS00890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JG738_RS00930	COG0544	peptidyl-prolyl cis-trans isomerase activity
JG738_RS00935	COG0740	serine-type endopeptidase activity
JG738_RS00940	COG0242	peptide deformylase activity
JG738_RS00945	COG0606	chelatase, subunit chli
JG738_RS00950	COG0739	heme binding
JG738_RS00950	COG1196	nuclear chromosome segregation
JG738_RS00950	COG0741	lytic transglycosylase activity
JG738_RS00960	COG2855	membrane
JG738_RS00965	COG0583	DNA-binding transcription factor activity
JG738_RS00970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JG738_RS00970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JG738_RS00980	COG3174	membrane
JG738_RS00985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JG738_RS00995	COG2022	thiamine diphosphate biosynthetic process
JG738_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JG738_RS01040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
JG738_RS01045	COG1518	maintenance of DNA repeat elements
JG738_RS01090	COG0733	neurotransmitter:sodium symporter activity
JG738_RS01130	COG0546	phosphoglycolate phosphatase activity
JG738_RS01145	COG3787	Belongs to the UPF0306 family
JG738_RS01160	COG1981	membrane
JG738_RS01185	COG0582	viral genome integration into host DNA
JG738_RS01195	COG0582	viral genome integration into host DNA
JG738_RS01205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JG738_RS01210	COG0482	sulfurtransferase activity
JG738_RS01215	COG0358	DNA primase activity
JG738_RS01225	COG0328	RNA-DNA hybrid ribonuclease activity
JG738_RS01230	COG0571	ribonuclease III activity
JG738_RS01235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JG738_RS01240	COG0586	Pfam SNARE associated Golgi protein
JG738_RS01255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JG738_RS01265	COG0051	transcription antitermination factor activity, RNA binding
JG738_RS01270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JG738_RS01275	COG0088	Forms part of the polypeptide exit tunnel
JG738_RS01280	COG0089	rRNA binding
JG738_RS01285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JG738_RS01290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JG738_RS01295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JG738_RS01300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JG738_RS01305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JG738_RS01310	COG0255	Belongs to the universal ribosomal protein uL29 family
JG738_RS01315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JG738_RS01320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JG738_RS01325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JG738_RS01330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JG738_RS01335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JG738_RS01340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JG738_RS01345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JG738_RS01350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JG738_RS01355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JG738_RS01360	COG0200	Binds to the 23S rRNA
JG738_RS01365	COG0201	protein transport
JG738_RS01370	COG0024	Methionine aminopeptidase
JG738_RS01375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JG738_RS01380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JG738_RS01385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JG738_RS01390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JG738_RS01395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JG738_RS01400	COG0202	RNA polymerase activity
JG738_RS01405	COG0203	ribosomal protein L17
JG738_RS01420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JG738_RS01430	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JG738_RS01435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JG738_RS01445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JG738_RS01470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JG738_RS01475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JG738_RS01490	COG0250	Participates in transcription elongation, termination and antitermination
JG738_RS01495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JG738_RS01500	COG0081	regulation of translation
JG738_RS01505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JG738_RS01510	COG0222	ribosome binding
JG738_RS01515	COG0085	RNA polymerase activity
JG738_RS01520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JG738_RS01525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JG738_RS01530	COG0049	tRNA binding
JG738_RS01535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JG738_RS01565	COG2201	protein-glutamate methylesterase activity
JG738_RS01575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JG738_RS01590	COG0724	RNA recognition motif
JG738_RS01595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JG738_RS01605	COG3706	GGDEF domain
JG738_RS01610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JG738_RS01620	COG1086	Polysaccharide biosynthesis protein
JG738_RS01625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JG738_RS01630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JG738_RS01645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JG738_RS01655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JG738_RS01660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JG738_RS01665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JG738_RS01670	COG0649	NAD binding
JG738_RS01695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JG738_RS01700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JG738_RS01705	COG0839	Belongs to the complex I subunit 6 family
JG738_RS01710	COG0713	ATP synthesis coupled electron transport
JG738_RS01715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JG738_RS01725	COG1007	ATP synthesis coupled electron transport
JG738_RS01730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JG738_RS01750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JG738_RS01755	COG0305	Participates in initiation and elongation during chromosome replication
JG738_RS01765	COG1295	ribonuclease BN
JG738_RS01770	COG0277	FAD linked oxidase domain protein
JG738_RS01780	COG0739	heme binding
JG738_RS01785	COG2239	Acts as a magnesium transporter
JG738_RS01805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JG738_RS01810	COG1121	(ABC) transporter
JG738_RS01840	COG2801	Transposase and inactivated derivatives
JG738_RS01865	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
JG738_RS01870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JG738_RS01875	COG0745	RESPONSE REGULATOR receiver
JG738_RS01915	COG0357	Ribosomal RNA small subunit methyltransferase G
JG738_RS01920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JG738_RS01925	COG0113	porphobilinogen synthase activity
JG738_RS01930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JG738_RS01940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JG738_RS01950	COG1074	ATP-dependent DNA helicase activity
JG738_RS01955	COG0247	lactate metabolic process
JG738_RS01960	COG3338	carbonate dehydratase activity
JG738_RS01965	COG3290	protein histidine kinase activity
JG738_RS01965	COG0840	transmembrane signaling receptor activity
JG738_RS01970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JG738_RS01980	COG0754	glutathionylspermidine amidase activity
JG738_RS01990	COG0628	permease
JG738_RS01995	COG2255	four-way junction helicase activity
JG738_RS02000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JG738_RS02005	COG0159	tryptophan synthase activity
JG738_RS02035	COG2995	paraquat-inducible protein a
JG738_RS02040	COG3008	intermembrane lipid transfer
JG738_RS02050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JG738_RS02055	COG0540	Belongs to the ATCase OTCase family
JG738_RS02065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JG738_RS02070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JG738_RS02095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JG738_RS02100	COG0193	aminoacyl-tRNA hydrolase activity
JG738_RS02110	COG0019	diaminopimelate decarboxylase activity
JG738_RS02120	COG1605	Chorismate mutase
JG738_RS02120	COG0077	Prephenate dehydratase
JG738_RS02125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JG738_RS02130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JG738_RS02135	COG0450	alkyl hydroperoxide reductase
JG738_RS02140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JG738_RS02145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JG738_RS02150	COG0105	UTP biosynthetic process
JG738_RS02160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JG738_RS02165	COG0416	fatty acid biosynthetic process
JG738_RS02170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JG738_RS02210	COG0714	Associated with various cellular activities
JG738_RS02240	COG0287	Prephenate dehydrogenase
JG738_RS02245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JG738_RS02250	COG1077	Cell shape determining protein MreB Mrl
JG738_RS02260	COG0642	Histidine kinase
JG738_RS02265	COG0745	RESPONSE REGULATOR receiver
JG738_RS02275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JG738_RS02285	COG0157	Belongs to the NadC ModD family
JG738_RS02300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JG738_RS02310	COG0083	homoserine kinase activity
JG738_RS02320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JG738_RS02330	COG0779	Required for maturation of 30S ribosomal subunits
JG738_RS02335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JG738_RS02335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JG738_RS02345	COG1570	exodeoxyribonuclease VII activity
JG738_RS02355	COG0616	signal peptide processing
JG738_RS02360	COG0402	S-adenosylhomocysteine deaminase activity
JG738_RS02365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JG738_RS02370	COG0006	proline dipeptidase activity
JG738_RS02375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JG738_RS02380	COG0455	bacterial-type flagellum organization
JG738_RS02385	COG0482	sulfurtransferase activity
JG738_RS02390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JG738_RS02395	COG0481	GTPase activity
JG738_RS02405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JG738_RS02460	COG1116	anion transmembrane transporter activity
JG738_RS02465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JG738_RS02475	COG4771	TonB-dependent receptor
JG738_RS02485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JG738_RS02490	COG0811	peptide transport
JG738_RS02495	COG0848	biopolymer transport protein
JG738_RS02510	COG1528	Iron-storage protein
JG738_RS02540	COG0716	FMN binding
JG738_RS02555	COG0731	radical SAM domain protein
JG738_RS02560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JG738_RS02570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JG738_RS02590	COG0004	ammonium transporteR
JG738_RS02600	COG2814	Major facilitator Superfamily
JG738_RS02615	COG1309	transcriptional regulator
JG738_RS02630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JG738_RS02645	COG1129	ABC transporter
JG738_RS02645	COG0842	Transport permease protein
JG738_RS02655	COG0842	Transport permease protein
JG738_RS02665	COG0418	dihydroorotase activity
JG738_RS02675	COG3850	Histidine kinase
JG738_RS02675	COG5002	protein histidine kinase activity
JG738_RS02680	COG0811	peptide transport
JG738_RS02685	COG0848	biopolymer transport protein
JG738_RS02710	COG1136	(ABC) transporter
JG738_RS02730	COG0584	glycerophosphoryl diester phosphodiesterase
JG738_RS02735	COG0459	protein refolding
JG738_RS02740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JG738_RS02765	COG0133	tryptophan synthase activity
JG738_RS02770	COG1671	Belongs to the UPF0178 family
JG738_RS02810	COG0582	viral genome integration into host DNA
JG738_RS02885	COG0629	single-stranded DNA binding
JG738_RS03015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JG738_RS03015	COG0616	signal peptide processing
JG738_RS03130	COG0284	orotidine-5'-phosphate decarboxylase activity
JG738_RS03135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JG738_RS03150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JG738_RS03170	COG3162	membrane
JG738_RS03190	COG0745	RESPONSE REGULATOR receiver
JG738_RS03225	COG0339	signal peptide processing
JG738_RS03230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JG738_RS03235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JG738_RS03240	COG0318	PFAM AMP-dependent synthetase and ligase
JG738_RS03250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JG738_RS03260	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JG738_RS03265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JG738_RS03270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JG738_RS03275	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JG738_RS03280	COG1077	Cell shape determining protein MreB Mrl
JG738_RS03290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JG738_RS03300	COG1858	cytochrome C peroxidase
JG738_RS03310	COG0646	methionine synthase
JG738_RS03310	COG1410	methionine synthase
JG738_RS03325	COG1194	a g-specific adenine glycosylase
JG738_RS03340	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JG738_RS03365	COG2195	Cleaves the N-terminal amino acid of tripeptides
JG738_RS03375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JG738_RS03380	COG0217	transcriptional regulatory protein
JG738_RS03385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JG738_RS03390	COG0191	fructose-bisphosphate aldolase activity
JG738_RS03400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JG738_RS03405	COG0306	phosphate transporter
JG738_RS03415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JG738_RS03470	COG2046	Belongs to the sulfate adenylyltransferase family
JG738_RS03475	COG0745	RESPONSE REGULATOR receiver
JG738_RS03480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JG738_RS03480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JG738_RS03485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JG738_RS03490	COG0489	protein tyrosine kinase activity
JG738_RS03500	COG0840	transmembrane signaling receptor activity
JG738_RS03505	COG0840	transmembrane signaling receptor activity
JG738_RS03505	COG3290	protein histidine kinase activity
JG738_RS03510	COG0745	RESPONSE REGULATOR receiver
JG738_RS03515	COG0835	chemotaxis
JG738_RS03515	COG0784	Response regulator, receiver
JG738_RS03520	COG0835	chemotaxis
JG738_RS03525	COG2198	Histidine kinase
JG738_RS03525	COG0643	Histidine kinase
JG738_RS03535	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JG738_RS03545	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JG738_RS03545	COG1776	CheC inhibitor of MCP methylation
JG738_RS03550	COG4786	Flagellar basal body rod
JG738_RS03565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JG738_RS03570	COG1706	bacterial-type flagellum-dependent cell motility
JG738_RS03580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JG738_RS03585	COG1419	protein localization to endoplasmic reticulum
JG738_RS03590	COG0455	bacterial-type flagellum organization
JG738_RS03595	COG1191	sigma factor activity
JG738_RS03610	COG1815	bacterial-type flagellum-dependent cell motility
JG738_RS03615	COG1558	bacterial-type flagellum-dependent cell motility
JG738_RS03620	COG1677	Flagellar hook-basal body complex protein FliE
JG738_RS03625	COG1766	The M ring may be actively involved in energy transduction
JG738_RS03635	COG1157	protein secretion by the type III secretion system
JG738_RS03645	COG1749	Flagellar hook protein flgE
JG738_RS03650	COG1580	Controls the rotational direction of flagella during chemotaxis
JG738_RS03665	COG1338	Plays a role in the flagellum-specific transport system
JG738_RS03670	COG1987	bacterial-type flagellum assembly
JG738_RS03675	COG1684	flagellar biosynthetic protein fliR
JG738_RS03680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JG738_RS03700	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
JG738_RS03715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JG738_RS03720	COG1516	flagellar protein fliS
JG738_RS03730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JG738_RS03745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JG738_RS03750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JG738_RS03755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JG738_RS03760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JG738_RS03775	COG0045	succinate-CoA ligase (ADP-forming) activity
JG738_RS03815	COG0165	Argininosuccinate lyase
JG738_RS03820	COG0537	adenosine 5'-monophosphoramidase activity
JG738_RS03825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JG738_RS03830	COG0072	phenylalanine-tRNA ligase activity
JG738_RS03830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JG738_RS03835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JG738_RS03840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JG738_RS03845	COG0539	negative regulation of cytoplasmic translation
JG738_RS03845	COG1185	polyribonucleotide nucleotidyltransferase activity
JG738_RS03850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JG738_RS03860	COG1566	PFAM secretion protein HlyD family protein
JG738_RS03865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JG738_RS03870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JG738_RS03880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JG738_RS03885	COG0070	glutamate synthase
JG738_RS03885	COG0069	glutamate synthase activity
JG738_RS03885	COG0067	glutamate synthase
JG738_RS03890	COG0493	'glutamate synthase
JG738_RS03900	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JG738_RS03905	COG0352	thiamine-phosphate diphosphorylase activity
JG738_RS03910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JG738_RS03920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JG738_RS03930	COG0730	response to heat
JG738_RS03935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JG738_RS03945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JG738_RS03945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JG738_RS03950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JG738_RS03950	COG1333	cytochrome c biogenesis protein
JG738_RS03955	COG0484	heat shock protein binding
JG738_RS03960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JG738_RS03965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JG738_RS03975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JG738_RS03980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JG738_RS03990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JG738_RS03995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JG738_RS04010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JG738_RS04030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JG738_RS04035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JG738_RS04050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JG738_RS04055	COG0629	single-stranded DNA binding
JG738_RS04060	COG0360	Binds together with S18 to 16S ribosomal RNA
JG738_RS04070	COG0557	exoribonuclease II activity
JG738_RS04075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JG738_RS04085	COG0471	metal ion transport
JG738_RS04090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JG738_RS04090	COG0758	DNA mediated transformation
JG738_RS04100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JG738_RS04110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JG738_RS04145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JG738_RS04150	COG0805	protein transport
JG738_RS04195	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
JG738_RS04205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JG738_RS04210	COG0494	nUDIX hydrolase
JG738_RS04215	COG0527	aspartate kinase activity
JG738_RS04230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JG738_RS04235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JG738_RS04240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JG738_RS04250	COG0196	riboflavin kinase activity
JG738_RS04255	COG1331	Highly conserved protein containing a thioredoxin domain
JG738_RS04260	COG4106	trans-aconitate 2-methyltransferase activity
JG738_RS04270	COG2404	hydrolase activity, acting on ester bonds
JG738_RS04280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JG738_RS04285	COG1420	regulation of RNA biosynthetic process
JG738_RS04290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JG738_RS04295	COG0443	Heat shock 70 kDa protein
JG738_RS04310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JG738_RS04315	COG1331	Highly conserved protein containing a thioredoxin domain
JG738_RS04320	COG4232	protein-disulfide reductase activity
JG738_RS04330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JG738_RS04340	COG3853	Toxic anion resistance protein (TelA)
JG738_RS04345	COG4260	virion core protein, lumpy skin disease virus
JG738_RS04360	COG0463	Glycosyl transferase, family 2
JG738_RS04370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JG738_RS04375	COG1355	regulation of microtubule-based process
JG738_RS04380	COG0101	tRNA pseudouridine synthase activity
JG738_RS04395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JG738_RS04400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JG738_RS04405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JG738_RS04410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JG738_RS04415	COG0012	GTP binding
JG738_RS04420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JG738_RS04425	COG0586	Pfam SNARE associated Golgi protein
JG738_RS04430	COG0133	tryptophan synthase activity
JG738_RS04435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JG738_RS04440	COG0698	ribose 5-phosphate isomerase
JG738_RS04445	COG1994	Peptidase M50
JG738_RS04450	COG0681	Belongs to the peptidase S26 family
JG738_RS04455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JG738_RS04485	COG2199	diguanylate cyclase activity
JG738_RS04485	COG2200	EAL domain
JG738_RS04485	COG3287	FIST C domain
JG738_RS04495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JG738_RS04510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JG738_RS04515	COG0066	3-isopropylmalate dehydratase activity
JG738_RS04520	COG0473	3-isopropylmalate dehydrogenase activity
JG738_RS04525	COG0617	tRNA 3'-terminal CCA addition
JG738_RS04530	COG0788	formyltetrahydrofolate deformylase activity
JG738_RS04535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JG738_RS04545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JG738_RS04545	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JG738_RS04550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JG738_RS04580	COG2989	Protein conserved in bacteria
JG738_RS04585	COG3108	Peptidase M15
JG738_RS04655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JG738_RS04670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JG738_RS04670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JG738_RS04710	COG0367	asparagine synthase
JG738_RS04720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JG738_RS04755	COG2336	PFAM SpoVT AbrB
JG738_RS04760	COG2337	Toxic component of a toxin-antitoxin (TA) module
JG738_RS04785	COG1373	ATPase (AAA superfamily
JG738_RS04835	COG0772	Belongs to the SEDS family
JG738_RS04840	COG0564	pseudouridine synthase activity
JG738_RS04850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JG738_RS04855	COG2884	Cell division ATP-binding protein ftsE
JG738_RS04870	COG0528	UMP kinase activity
JG738_RS04875	COG1758	RNA polymerase activity
JG738_RS04880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JG738_RS04885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JG738_RS04895	COG0860	N-Acetylmuramoyl-L-alanine amidase
JG738_RS04900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JG738_RS04940	COG0563	adenylate kinase activity
JG738_RS04950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JG738_RS04955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JG738_RS04960	COG0497	DNA recombination
JG738_RS04965	COG0084	hydrolase, TatD family'
JG738_RS04970	COG1388	LysM domain
JG738_RS04970	COG3584	3D domain protein
JG738_RS04975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JG738_RS04980	COG0131	Imidazoleglycerol-phosphate dehydratase
JG738_RS04985	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JG738_RS05000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JG738_RS05005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JG738_RS05020	COG0530	calcium, potassium:sodium antiporter activity
JG738_RS05025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JG738_RS05030	COG0840	transmembrane signaling receptor activity
JG738_RS05035	COG2201	protein-glutamate methylesterase activity
JG738_RS05040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JG738_RS05045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JG738_RS05050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JG738_RS05055	COG0387	Pfam Sodium calcium exchanger
JG738_RS05065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JG738_RS05065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JG738_RS05075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JG738_RS05080	COG1763	Mo-molybdopterin cofactor biosynthetic process
JG738_RS05100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JG738_RS05105	COG0688	phosphatidylethanolamine metabolic process
JG738_RS05125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JG738_RS05130	COG0501	Belongs to the peptidase M48B family
JG738_RS05135	COG1832	CoA-binding protein
JG738_RS05140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JG738_RS05150	COG0028	Belongs to the TPP enzyme family
JG738_RS05155	COG0440	acetolactate synthase activity
JG738_RS05160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JG738_RS05170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JG738_RS05175	COG1287	oligosaccharyl transferase activity
JG738_RS05185	COG0436	Aminotransferase
JG738_RS05190	COG1045	serine acetyltransferase
JG738_RS05195	COG1166	arginine decarboxylase activity
JG738_RS05200	COG0124	histidyl-tRNA synthetase
JG738_RS05205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JG738_RS05210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JG738_RS05215	COG0163	prenyltransferase activity
JG738_RS05230	COG0776	regulation of translation
JG738_RS05235	COG1674	ftsk spoiiie
JG738_RS05235	COG1196	nuclear chromosome segregation
JG738_RS05245	COG1049	propionate catabolic process, 2-methylcitrate cycle
JG738_RS05250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JG738_RS05255	COG0653	protein targeting
JG738_RS05280	COG0039	L-malate dehydrogenase activity
JG738_RS05290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JG738_RS05295	COG0045	succinate-CoA ligase (ADP-forming) activity
JG738_RS05300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JG738_RS05315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JG738_RS05315	COG0674	pyruvate-flavodoxin oxidoreductase activity
JG738_RS05320	COG3962	Belongs to the TPP enzyme family
JG738_RS05390	COG0659	secondary active sulfate transmembrane transporter activity
JG738_RS05395	COG0525	valine-tRNA ligase activity
JG738_RS05405	COG1459	type II secretion system
JG738_RS05410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JG738_RS05455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JG738_RS05460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JG738_RS05465	COG0359	binds to the 23S rRNA
JG738_RS05470	COG0137	argininosuccinate synthase activity
JG738_RS05475	COG0742	ribosomal rna small subunit methyltransferase
JG738_RS05480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JG738_RS05495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JG738_RS05500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JG738_RS05505	COG0727	PFAM Uncharacterised protein family (UPF0153)
JG738_RS05515	COG0134	indole-3-glycerol-phosphate synthase activity
JG738_RS05535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JG738_RS05555	COG0582	viral genome integration into host DNA
JG738_RS05560	COG1309	transcriptional regulator
JG738_RS05575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JG738_RS05580	COG0789	Transcriptional regulator
JG738_RS05585	COG0484	heat shock protein binding
JG738_RS05595	COG0326	Molecular chaperone. Has ATPase activity
JG738_RS05625	COG0058	SHG alpha-glucan phosphorylase activity
JG738_RS05630	COG0033	Phosphoglucomutase
JG738_RS05635	COG0166	Belongs to the GPI family
JG738_RS05640	COG0058	SHG alpha-glucan phosphorylase activity
JG738_RS05650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JG738_RS05660	COG1449	Belongs to the glycosyl hydrolase 57 family
JG738_RS05670	COG1940	carbohydrate kinase activity
JG738_RS05675	COG0297	glycogen (starch) synthase activity
JG738_RS05680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JG738_RS05690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JG738_RS05695	COG0022	dehydrogenase e1 component
JG738_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
JG738_RS05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JG738_RS05740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JG738_RS05750	COG0574	Belongs to the PEP-utilizing enzyme family
JG738_RS05750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JG738_RS05755	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JG738_RS05760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JG738_RS05770	COG1509	lysine 2,3-aminomutase activity
JG738_RS05805	COG2010	Cytochrome c
JG738_RS05815	COG2132	Multicopper oxidase
JG738_RS05840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JG738_RS05855	COG0745	RESPONSE REGULATOR receiver
JG738_RS05860	COG0642	Histidine kinase
JG738_RS05865	COG2205	protein histidine kinase activity
JG738_RS05870	COG0205	6-phosphofructokinase activity
JG738_RS05880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JG738_RS05935	COG0501	Belongs to the peptidase M48B family
JG738_RS05940	COG2988	succinylglutamate desuccinylase activity
JG738_RS05945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JG738_RS05955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JG738_RS05960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JG738_RS05970	COG0706	membrane insertase activity
JG738_RS05975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JG738_RS05980	COG0594	ribonuclease P activity
JG738_RS05985	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JG738_RS05990	COG0517	IMP dehydrogenase activity
JG738_RS06005	COG0542	response to heat
JG738_RS06010	COG0793	Belongs to the peptidase S41A family
JG738_RS06015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JG738_RS06020	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JG738_RS06025	COG0047	phosphoribosylformylglycinamidine synthase activity
JG738_RS06035	COG0204	Acyl-transferase
JG738_RS06040	COG4608	Belongs to the ABC transporter superfamily
JG738_RS06045	COG2824	Alkylphosphonate utilization operon protein PhnA
JG738_RS06055	COG0745	RESPONSE REGULATOR receiver
JG738_RS06060	COG0704	Plays a role in the regulation of phosphate uptake
JG738_RS06065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JG738_RS06075	COG0573	inorganic phosphate transmembrane transporter activity
JG738_RS06080	COG0581	inorganic phosphate transmembrane transporter activity
JG738_RS06085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JG738_RS06090	COG1196	nuclear chromosome segregation
JG738_RS06090	COG3264	Mechanosensitive ion channel
JG738_RS06100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JG738_RS06105	COG0492	ferredoxin-NADP+ reductase activity
JG738_RS06115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JG738_RS06125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JG738_RS06130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JG738_RS06140	COG0352	thiamine-phosphate diphosphorylase activity
JG738_RS06150	COG0356	it plays a direct role in the translocation of protons across the membrane
JG738_RS06160	COG1137	ATPase activity
JG738_RS06165	COG0802	atpase or kinase
JG738_RS06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JG738_RS06175	COG0475	glutathione-regulated potassium exporter activity
JG738_RS06180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JG738_RS06185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JG738_RS06190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JG738_RS06195	COG0719	Fe-S assembly protein
JG738_RS06200	COG0396	ATPase activity
JG738_RS06210	COG2151	metal-sulfur cluster biosynthetic enzyme
JG738_RS06215	COG0375	protein maturation
JG738_RS06220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JG738_RS06220	COG1024	Enoyl-CoA hydratase
JG738_RS06225	COG0309	Hydrogenase expression formation protein (HypE)
JG738_RS06230	COG0409	Hydrogenase expression formation protein
JG738_RS06235	COG0298	carbon dioxide binding
JG738_RS06240	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JG738_RS06255	COG1252	NADH dehydrogenase
JG738_RS06260	COG3022	response to hydroperoxide
JG738_RS06265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JG738_RS06280	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
JG738_RS06285	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
JG738_RS06290	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
JG738_RS06305	COG1309	transcriptional regulator
JG738_RS06315	COG0181	hydroxymethylbilane synthase activity
JG738_RS06325	COG3030	protein affecting phage T7 exclusion by the F plasmid
JG738_RS06330	COG0442	prolyl-tRNA aminoacylation
JG738_RS06335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JG738_RS06340	COG0142	geranyltranstransferase activity
JG738_RS06360	COG0275	rRNA processing
JG738_RS06365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JG738_RS06370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JG738_RS06375	COG0849	cell division
JG738_RS06385	COG1127	ABC transporter
JG738_RS06395	COG2890	protein-(glutamine-N5) methyltransferase activity
JG738_RS06400	COG0501	Belongs to the peptidase M48B family
JG738_RS06405	COG0488	(ABC) transporter
JG738_RS06415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JG738_RS06420	COG1324	tolerance protein
JG738_RS06425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JG738_RS06430	COG1663	tetraacyldisaccharide 4'-kinase activity
JG738_RS06435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JG738_RS06440	COG2833	Protein of unknown function (DUF455)
JG738_RS06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JG738_RS06450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JG738_RS06450	COG2050	protein possibly involved in aromatic compounds catabolism
JG738_RS06460	COG1011	Hydrolase
JG738_RS06465	COG0500	methyltransferase
JG738_RS06480	COG1418	mRNA catabolic process
JG738_RS06495	COG0552	protein localization to endoplasmic reticulum
JG738_RS06500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JG738_RS06510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JG738_RS06515	COG0736	holo-[acyl-carrier-protein] synthase activity
JG738_RS06520	COG2104	thiamine diphosphate biosynthetic process
JG738_RS06550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JG738_RS06565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JG738_RS06580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JG738_RS06605	COG0521	Mo-molybdopterin cofactor biosynthetic process
JG738_RS06620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JG738_RS06625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JG738_RS06635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JG738_RS06645	COG0343	queuine tRNA-ribosyltransferase activity
JG738_RS06650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JG738_RS06655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JG738_RS06670	COG0436	Aminotransferase
JG738_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JG738_RS06700	COG1254	Belongs to the acylphosphatase family
JG738_RS06710	COG2860	membrane
JG738_RS06715	COG2081	HI0933 family
JG738_RS06720	COG1181	Belongs to the D-alanine--D-alanine ligase family
JG738_RS06725	COG0632	four-way junction helicase activity
JG738_RS06735	COG0728	peptidoglycan biosynthetic process
JG738_RS06740	COG0215	cysteine-tRNA ligase activity
JG738_RS06745	COG1132	(ABC) transporter
JG738_RS06750	COG0167	dihydroorotate dehydrogenase activity
JG738_RS06765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JG738_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
JG738_RS06775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JG738_RS06780	COG0750	zinc metalloprotease
JG738_RS06785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JG738_RS06795	COG0585	pseudouridine synthase activity
JG738_RS06815	COG2048	Heterodisulfide reductase, subunit B
JG738_RS06830	COG1573	uracil-dna glycosylase
JG738_RS06840	COG0824	Thioesterase
JG738_RS06850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JG738_RS06850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JG738_RS06885	COG0587	DNA-directed DNA polymerase activity
JG738_RS06890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JG738_RS06895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JG738_RS06895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JG738_RS06905	COG1216	Glycosyl transferase, family 2
JG738_RS06905	COG0463	Glycosyl transferase, family 2
JG738_RS06910	COG0693	protein deglycase activity
JG738_RS06935	COG0037	tRNA processing
JG738_RS06940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JG738_RS06950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JG738_RS06955	COG1047	Peptidyl-prolyl cis-trans
JG738_RS06970	COG0823	Involved in the tonB-independent uptake of proteins
JG738_RS06980	COG0848	biopolymer transport protein
JG738_RS06985	COG0811	peptide transport
JG738_RS06990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JG738_RS06995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JG738_RS07000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JG738_RS07005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JG738_RS07010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JG738_RS07015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JG738_RS07025	COG1475	DNA binding
JG738_RS07030	COG1192	Involved in chromosome partitioning
JG738_RS07040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JG738_RS07045	COG0585	pseudouridine synthase activity
JG738_RS07050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JG738_RS07055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JG738_RS07060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JG738_RS07065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JG738_RS07070	COG0251	oxidation-reduction process
JG738_RS07080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JG738_RS07085	COG3150	esterase
JG738_RS07135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JG738_RS07145	COG1215	transferase activity, transferring glycosyl groups
JG738_RS07170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JG738_RS07170	COG1213	nucleotidyl transferase
JG738_RS07180	COG2226	methyltransferase
JG738_RS07190	COG1193	negative regulation of DNA recombination
JG738_RS07210	COG0436	Aminotransferase
JG738_RS07215	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JG738_RS07230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JG738_RS07250	COG0517	IMP dehydrogenase activity
JG738_RS07250	COG0516	GMP reductase activity
JG738_RS07255	COG0154	amidase activity
JG738_RS07260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JG738_RS07265	COG1058	Belongs to the CinA family
JG738_RS07265	COG1546	Belongs to the CinA family
JG738_RS07300	COG1796	DNA polymerase
JG738_RS07300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JG738_RS07310	COG0745	RESPONSE REGULATOR receiver
JG738_RS07315	COG0642	Histidine kinase
JG738_RS07335	COG3118	belongs to the thioredoxin family
JG738_RS07365	COG1073	alpha beta
JG738_RS07420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JG738_RS07430	COG1881	PFAM PEBP family protein
JG738_RS07435	COG0560	Phosphoserine phosphatase
JG738_RS07450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JG738_RS07455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JG738_RS07460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JG738_RS07465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JG738_RS07475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JG738_RS07480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JG738_RS07485	COG0463	Glycosyl transferase, family 2
JG738_RS07515	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JG738_RS07515	COG2199	diguanylate cyclase activity
JG738_RS07635	COG0582	viral genome integration into host DNA
JG738_RS07645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JG738_RS07655	COG1185	polyribonucleotide nucleotidyltransferase activity
JG738_RS07660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JG738_RS07665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JG738_RS07685	COG0519	Catalyzes the synthesis of GMP from XMP
JG738_RS07685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JG738_RS07695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JG738_RS07705	COG0322	excinuclease ABC activity
JG738_RS07715	COG4999	Histidine kinase
JG738_RS07715	COG3850	Histidine kinase
JG738_RS07715	COG3437	response regulator, receiver
JG738_RS07715	COG2205	protein histidine kinase activity
JG738_RS07720	COG0745	RESPONSE REGULATOR receiver
JG738_RS07725	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JG738_RS07730	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JG738_RS07735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JG738_RS07760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JG738_RS07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JG738_RS07770	COG0612	Peptidase, M16
JG738_RS07775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
JG738_RS07785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JG738_RS07790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JG738_RS07795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JG738_RS07805	COG0697	spore germination
JG738_RS07815	COG0668	transmembrane transport
JG738_RS07820	COG1160	GTP binding
JG738_RS07825	COG0180	Tryptophanyl-tRNA synthetase
JG738_RS07830	COG1993	acr, cog1993
JG738_RS07835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JG738_RS07850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JG738_RS07855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JG738_RS07870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JG738_RS07875	COG1183	phosphatidylcholine synthase activity
JG738_RS07880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JG738_RS07885	COG2264	protein methyltransferase activity
JG738_RS07890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JG738_RS07895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JG738_RS07910	COG2194	sulfuric ester hydrolase activity
JG738_RS07925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JG738_RS07955	COG0367	asparagine synthase
JG738_RS07960	COG0438	transferase activity, transferring glycosyl groups
JG738_RS07980	COG0859	PFAM glycosyl transferase family 9
JG738_RS07985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JG738_RS07990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JG738_RS07990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JG738_RS08000	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JG738_RS08015	COG2217	Heavy metal translocating P-type atpase
JG738_RS08035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JG738_RS08040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JG738_RS08055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JG738_RS08070	COG1692	metallophosphoesterase
JG738_RS08075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JG738_RS08080	COG0285	dihydrofolate synthase activity
JG738_RS08090	COG0495	leucyl-tRNA aminoacylation
JG738_RS08095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JG738_RS08100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JG738_RS08110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JG738_RS08115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JG738_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JG738_RS08140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JG738_RS08145	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JG738_RS08150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JG738_RS08155	COG3706	GGDEF domain
JG738_RS08160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JG738_RS08185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JG738_RS08195	COG0195	Participates in both transcription termination and antitermination
JG738_RS08200	COG0601	transmembrane transport
JG738_RS08215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JG738_RS08220	COG0149	triose-phosphate isomerase activity
JG738_RS08225	COG0126	phosphoglycerate kinase activity
JG738_RS08235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JG738_RS08240	COG0799	negative regulation of ribosome biogenesis
JG738_RS08245	COG0018	arginyl-trna synthetase
JG738_RS08250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JG738_RS08255	COG0194	GDP metabolic process
JG738_RS08270	COG0335	large ribosomal subunit rRNA binding
JG738_RS08275	COG0336	Belongs to the RNA methyltransferase TrmD family
JG738_RS08280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JG738_RS08290	COG0228	four-way junction DNA binding
JG738_RS08295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JG738_RS08300	COG0564	pseudouridine synthase activity
JG738_RS08310	COG1519	Transferase
JG738_RS08310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JG738_RS08320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JG738_RS08325	COG0752	glycyl-tRNA synthetase alpha subunit
JG738_RS08340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JG738_RS08345	COG0826	peptidase U32
JG738_RS08355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JG738_RS08360	COG0174	glutamine synthetase
JG738_RS08380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JG738_RS08385	COG0444	Belongs to the ABC transporter superfamily
JG738_RS08390	COG0156	8-amino-7-oxononanoate synthase activity
JG738_RS08395	COG2815	serine threonine protein kinase
JG738_RS08395	COG0515	serine threonine protein kinase
JG738_RS08400	COG0424	maF-like protein
JG738_RS08405	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JG738_RS08415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JG738_RS08425	COG0772	Belongs to the SEDS family
JG738_RS08430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JG738_RS08435	COG3706	GGDEF domain
JG738_RS08440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JG738_RS08445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JG738_RS08455	COG1136	(ABC) transporter
JG738_RS08460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JG738_RS08465	COG0052	Belongs to the universal ribosomal protein uS2 family
JG738_RS08470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JG738_RS08480	COG3706	GGDEF domain
JG738_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
JG738_RS08500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JG738_RS08500	COG0140	phosphoribosyl-ATP diphosphatase activity
JG738_RS08510	COG1242	4 iron, 4 sulfur cluster binding
JG738_RS08515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JG738_RS08520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JG738_RS08525	COG0492	ferredoxin-NADP+ reductase activity
JG738_RS08530	COG3118	belongs to the thioredoxin family
JG738_RS08535	COG0792	nuclease activity
JG738_RS08540	COG3383	formate dehydrogenase (NAD+) activity
JG738_RS08545	COG0460	homoserine dehydrogenase
JG738_RS08550	COG0436	Aminotransferase
JG738_RS08565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JG738_RS08570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JG738_RS08575	COG0254	rRNA binding
JG738_RS08580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JG738_RS08595	COG2165	general secretion pathway protein
JG738_RS08610	COG0556	nucleotide-excision repair
JG738_RS08615	COG0288	reversible hydration of carbon dioxide
JG738_RS08620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JG738_RS08625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JG738_RS08635	COG0242	peptide deformylase activity
JG738_RS08640	COG1301	dicarboxylic acid transport
JG738_RS08645	COG2176	DNA-directed DNA polymerase activity
JG738_RS08650	COG0135	phosphoribosylanthranilate isomerase activity
JG738_RS08655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JG738_RS08660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JG738_RS08665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JG738_RS08680	COG0825	malonyl-CoA metabolic process
JG738_RS08685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JG738_RS08690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JG738_RS08700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JG738_RS08705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JG738_RS08745	COG1473	amidohydrolase
JG738_RS08750	COG2172	sigma factor antagonist activity
JG738_RS08805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JG738_RS08840	COG1074	ATP-dependent DNA helicase activity
JG738_RS08855	COG3328	transposase activity
JG738_RS08860	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JG738_RS08875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JG738_RS08885	COG0303	'Molybdopterin
JG738_RS08895	COG0720	synthase
JG738_RS08900	COG0602	queuosine metabolic process
JG738_RS08905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JG738_RS08915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JG738_RS08920	COG0723	plastoquinol--plastocyanin reductase activity
JG738_RS08930	COG0445	tRNA wobble uridine modification
JG738_RS08985	COG1013	pyruvate-flavodoxin oxidoreductase activity
JG738_RS08990	COG0674	pyruvate-flavodoxin oxidoreductase activity
JG738_RS08995	COG1144	Oxidoreductase
JG738_RS09000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JG738_RS09005	COG0546	phosphoglycolate phosphatase activity
JG738_RS09015	COG0745	RESPONSE REGULATOR receiver
JG738_RS09020	COG0642	Histidine kinase
JG738_RS09035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JG738_RS09040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JG738_RS09055	COG0348	domain, Protein
JG738_RS09080	COG3278	Belongs to the heme-copper respiratory oxidase family
JG738_RS09110	COG0505	Belongs to the CarA family
JG738_RS09120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JG738_RS09125	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JG738_RS09130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JG738_RS09145	COG0071	Belongs to the small heat shock protein (HSP20) family
JG738_RS09160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JG738_RS09165	COG2814	Major facilitator Superfamily
JG738_RS09175	COG0303	'Molybdopterin
JG738_RS09180	COG2902	Dehydrogenase
JG738_RS09185	COG0314	molybdopterin synthase activity
JG738_RS09195	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
JG738_RS09200	COG1858	cytochrome C peroxidase
JG738_RS09205	COG2199	diguanylate cyclase activity
JG738_RS09205	COG3287	FIST C domain
JG738_RS09205	COG2200	EAL domain
JG738_RS09210	COG0280	phosphate acetyltransferase
JG738_RS09210	COG0281	malic enzyme
JG738_RS09215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JG738_RS09220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JG738_RS09225	COG2171	N-acyltransferase activity
JG738_RS09235	COG0439	Biotin carboxylase
JG738_RS09240	COG0511	ligase activity, forming carbon-carbon bonds
JG738_RS09245	COG0717	Belongs to the dCTP deaminase family
JG738_RS09260	COG0598	Magnesium transport protein CorA
JG738_RS09270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JG738_RS09280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JG738_RS09285	COG0475	glutathione-regulated potassium exporter activity
JG738_RS09285	COG0569	domain protein
JG738_RS09300	COG0148	phosphopyruvate hydratase activity
JG738_RS09305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JG738_RS09325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JG738_RS09330	COG5001	Diguanylate cyclase
JG738_RS09335	COG1063	alcohol dehydrogenase
JG738_RS09340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JG738_RS09345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JG738_RS09360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JG738_RS09365	COG0575	Belongs to the CDS family
JG738_RS09375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JG738_RS09380	COG1489	DNA binding
JG738_RS09390	COG0577	efflux transmembrane transporter activity
JG738_RS09390	COG1136	(ABC) transporter
JG738_RS09395	COG0577	efflux transmembrane transporter activity
JG738_RS09395	COG1136	(ABC) transporter
JG738_RS09400	COG0577	efflux transmembrane transporter activity
JG738_RS09400	COG1136	(ABC) transporter
JG738_RS09405	COG2095	MarC family integral membrane protein
JG738_RS09415	COG0746	molybdenum cofactor guanylyltransferase activity
JG738_RS09435	COG0315	cyclic pyranopterin monophosphate synthase activity
JG738_RS09465	COG0513	Belongs to the DEAD box helicase family
JG738_RS09480	COG0483	inositol monophosphate 1-phosphatase activity
JG738_RS09485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JG738_RS09490	COG0745	RESPONSE REGULATOR receiver
JG738_RS09495	COG0642	Histidine kinase
JG738_RS09510	COG5001	Diguanylate cyclase
JG738_RS09510	COG5002	protein histidine kinase activity
JG738_RS09530	COG0569	domain protein
JG738_RS09535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JG738_RS09540	COG0038	chloride channel
JG738_RS09560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JG738_RS09565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JG738_RS09575	COG1283	sodium-dependent phosphate transmembrane transporter activity
JG738_RS09595	COG2326	polyphosphate kinase activity
JG738_RS09600	COG1110	DNA topoisomerase II activity
JG738_RS09625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JG738_RS09630	COG0602	queuosine metabolic process
JG738_RS09670	COG1522	sequence-specific DNA binding
JG738_RS09685	COG1648	precorrin-2 dehydrogenase activity
JG738_RS09685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JG738_RS09720	COG0348	domain, Protein
JG738_RS09735	COG0437	4 iron, 4 sulfur cluster binding
JG738_RS09750	COG4263	nitrous-oxide reductase activity
JG738_RS09755	COG1648	precorrin-2 dehydrogenase activity
JG738_RS09755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JG738_RS09765	COG0535	radical SAM domain protein
JG738_RS09770	COG2010	Cytochrome c
JG738_RS09810	COG0840	transmembrane signaling receptor activity
JG738_RS09830	COG3043	anaerobic respiration
JG738_RS09835	COG0348	domain, Protein
JG738_RS09840	COG0437	4 iron, 4 sulfur cluster binding
JG738_RS09845	COG0243	molybdopterin cofactor binding
JG738_RS09865	COG2151	metal-sulfur cluster biosynthetic enzyme
JG738_RS09890	COG0714	Associated with various cellular activities
JG738_RS09930	COG1140	nitrate reductase beta subunit
JG738_RS09935	COG0243	molybdopterin cofactor binding
JG738_RS09955	COG0489	protein tyrosine kinase activity
JG738_RS09990	COG3258	Cytochrome c
JG738_RS10010	COG5002	protein histidine kinase activity
JG738_RS10060	COG0670	Belongs to the BI1 family
JG738_RS10065	COG0352	thiamine-phosphate diphosphorylase activity
JG738_RS10080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JG738_RS10090	COG0233	cytoplasmic translational termination
JG738_RS10095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JG738_RS10115	COG0778	Nitroreductase
JG738_RS10125	COG1217	gtp-binding protein TYPA
JG738_RS10130	COG0546	phosphoglycolate phosphatase activity
JG738_RS10165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JG738_RS10180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JG738_RS10195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JG738_RS10240	COG1459	type II secretion system
JG738_RS10250	COG1192	Involved in chromosome partitioning
JG738_RS10270	COG0463	Glycosyl transferase, family 2