locus-tag	class	description
NHAM_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NHAM_RS00045	COG1741	Belongs to the pirin family
NHAM_RS00050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHAM_RS00055	COG0728	peptidoglycan biosynthetic process
NHAM_RS00060	COG0180	Tryptophanyl-tRNA synthetase
NHAM_RS00075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NHAM_RS00100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHAM_RS00105	COG1702	phosphate starvation-inducible protein PhoH
NHAM_RS00110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NHAM_RS00115	COG1253	flavin adenine dinucleotide binding
NHAM_RS00120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NHAM_RS00125	COG1396	sequence-specific DNA binding
NHAM_RS00130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NHAM_RS00135	COG0779	Required for maturation of 30S ribosomal subunits
NHAM_RS00150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NHAM_RS00155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NHAM_RS00160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NHAM_RS00165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NHAM_RS00170	COG1185	polyribonucleotide nucleotidyltransferase activity
NHAM_RS00180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
NHAM_RS00195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NHAM_RS00205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHAM_RS00235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NHAM_RS00240	COG2226	methyltransferase
NHAM_RS00245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NHAM_RS00250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NHAM_RS00255	COG0756	dUTP diphosphatase activity
NHAM_RS00260	COG2205	protein histidine kinase activity
NHAM_RS00265	COG3178	'Phosphotransferase
NHAM_RS00275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NHAM_RS00280	COG2887	Belongs to the helicase family. UvrD subfamily
NHAM_RS00285	COG1074	ATP-dependent DNA helicase activity
NHAM_RS00295	COG0285	dihydrofolate synthase activity
NHAM_RS00300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NHAM_RS00305	COG0159	tryptophan synthase activity
NHAM_RS00310	COG0133	tryptophan synthase activity
NHAM_RS00315	COG0135	phosphoribosylanthranilate isomerase activity
NHAM_RS00325	COG0776	regulation of translation
NHAM_RS00330	COG0616	signal peptide processing
NHAM_RS00360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHAM_RS00360	COG0072	phenylalanine-tRNA ligase activity
NHAM_RS00365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NHAM_RS00370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NHAM_RS00375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NHAM_RS00380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NHAM_RS00405	COG3118	belongs to the thioredoxin family
NHAM_RS00415	COG2835	tetraacyldisaccharide 4'-kinase activity
NHAM_RS00420	COG0004	ammonium transporteR
NHAM_RS00425	COG0347	Belongs to the P(II) protein family
NHAM_RS00430	COG0347	Belongs to the P(II) protein family
NHAM_RS00435	COG1946	Acyl-CoA thioesterase
NHAM_RS00440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHAM_RS00445	COG0436	Aminotransferase
NHAM_RS00450	COG1674	ftsk spoiiie
NHAM_RS00455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NHAM_RS00470	COG0745	RESPONSE REGULATOR receiver
NHAM_RS00480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NHAM_RS00485	COG0625	glutathione transferase activity
NHAM_RS00490	COG0495	leucyl-tRNA aminoacylation
NHAM_RS00505	COG2827	Endonuclease containing a URI domain
NHAM_RS00520	COG0357	Ribosomal RNA small subunit methyltransferase G
NHAM_RS00525	COG0445	tRNA wobble uridine modification
NHAM_RS00530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NHAM_RS00535	COG1331	Highly conserved protein containing a thioredoxin domain
NHAM_RS00540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NHAM_RS00545	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS00550	COG3328	transposase activity
NHAM_RS00555	COG1981	membrane
NHAM_RS00560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NHAM_RS00565	COG0424	maF-like protein
NHAM_RS00570	COG0237	dephospho-CoA kinase activity
NHAM_RS00575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NHAM_RS00580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NHAM_RS00590	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NHAM_RS00600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NHAM_RS00605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NHAM_RS00610	COG0131	Imidazoleglycerol-phosphate dehydratase
NHAM_RS00620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NHAM_RS00625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NHAM_RS00630	COG0107	imidazoleglycerol-phosphate synthase activity
NHAM_RS00635	COG0140	phosphoribosyl-ATP diphosphatase activity
NHAM_RS00640	COG1072	(Pantothenic acid kinase))
NHAM_RS00645	COG2205	protein histidine kinase activity
NHAM_RS00645	COG5002	protein histidine kinase activity
NHAM_RS00645	COG0784	Response regulator, receiver
NHAM_RS00660	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS00715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS00725	COG0189	ligase activity
NHAM_RS00730	COG0792	nuclease activity
NHAM_RS00735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NHAM_RS00745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NHAM_RS00750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NHAM_RS00755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NHAM_RS00760	COG1420	regulation of RNA biosynthetic process
NHAM_RS00765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NHAM_RS00775	COG0443	Heat shock 70 kDa protein
NHAM_RS00780	COG0484	heat shock protein binding
NHAM_RS00785	COG3963	phosphatidate phosphatase activity
NHAM_RS00790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NHAM_RS00795	COG0588	phosphoglycerate mutase activity
NHAM_RS00810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NHAM_RS00815	COG0539	negative regulation of cytoplasmic translation
NHAM_RS00820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NHAM_RS00825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NHAM_RS00840	COG0071	Belongs to the small heat shock protein (HSP20) family
NHAM_RS00850	COG0129	dihydroxy-acid dehydratase activity
NHAM_RS00860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHAM_RS00865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NHAM_RS00870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NHAM_RS00885	COG1137	ATPase activity
NHAM_RS00890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NHAM_RS00925	COG1968	undecaprenyl-diphosphatase activity
NHAM_RS00935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHAM_RS00940	COG0534	Mate efflux family protein
NHAM_RS00960	COG0405	Gamma-glutamyltransferase
NHAM_RS00970	COG3258	Cytochrome c
NHAM_RS00980	COG0138	bifunctional purine biosynthesis protein purh
NHAM_RS01005	COG1376	ErfK ybiS ycfS ynhG family protein
NHAM_RS01010	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
NHAM_RS01055	COG1999	signal sequence binding
NHAM_RS01070	COG1595	DNA-templated transcription, initiation
NHAM_RS01095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHAM_RS01105	COG0717	Belongs to the dCTP deaminase family
NHAM_RS01130	COG2967	ApaG domain
NHAM_RS01145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NHAM_RS01170	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NHAM_RS01180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHAM_RS01195	COG2885	chlorophyll binding
NHAM_RS01200	COG0501	Belongs to the peptidase M48B family
NHAM_RS01210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NHAM_RS01215	COG1201	RNA secondary structure unwinding
NHAM_RS01225	COG0583	DNA-binding transcription factor activity
NHAM_RS01230	COG0697	spore germination
NHAM_RS01240	COG0730	response to heat
NHAM_RS01270	COG0681	Belongs to the peptidase S26 family
NHAM_RS01275	COG0312	modulator of DNA gyrase
NHAM_RS01285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHAM_RS01290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS01295	COG0109	protoheme IX farnesyltransferase activity
NHAM_RS01305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NHAM_RS01325	COG0612	Peptidase, M16
NHAM_RS01330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHAM_RS01340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NHAM_RS01345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NHAM_RS01355	COG0356	it plays a direct role in the translocation of protons across the membrane
NHAM_RS01380	COG2205	protein histidine kinase activity
NHAM_RS01380	COG2198	Histidine kinase
NHAM_RS01380	COG0784	Response regulator, receiver
NHAM_RS01390	COG0156	8-amino-7-oxononanoate synthase activity
NHAM_RS01395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NHAM_RS01420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS01445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NHAM_RS01450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NHAM_RS01455	COG5328	Belongs to the UPF0262 family
NHAM_RS01460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NHAM_RS01480	COG0424	maF-like protein
NHAM_RS01485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NHAM_RS01495	COG0582	viral genome integration into host DNA
NHAM_RS01815	COG0330	HflC and HflK could
NHAM_RS01825	COG0784	Response regulator, receiver
NHAM_RS01825	COG4191	Histidine kinase
NHAM_RS01865	COG1024	Enoyl-CoA hydratase
NHAM_RS01865	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHAM_RS01870	COG0183	Belongs to the thiolase family
NHAM_RS01880	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NHAM_RS01890	COG3447	MASE1 domain protein
NHAM_RS01890	COG5002	protein histidine kinase activity
NHAM_RS01890	COG5001	Diguanylate cyclase
NHAM_RS01910	COG1278	Cold shock
NHAM_RS01965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NHAM_RS01970	COG3474	cytochrome
NHAM_RS01975	COG4166	transmembrane transport
NHAM_RS01980	COG4166	transmembrane transport
NHAM_RS01985	COG4174	ABC transporter (Permease)
NHAM_RS01990	COG4239	(ABC) transporter, permease
NHAM_RS01995	COG4172	Belongs to the ABC transporter superfamily
NHAM_RS02005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHAM_RS02040	COG4964	Belongs to the GSP D family
NHAM_RS02080	COG1278	Cold shock
NHAM_RS02085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NHAM_RS02090	COG0513	Belongs to the DEAD box helicase family
NHAM_RS02095	COG0564	pseudouridine synthase activity
NHAM_RS02100	COG0552	protein localization to endoplasmic reticulum
NHAM_RS02105	COG2917	probably involved in intracellular septation
NHAM_RS02130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NHAM_RS02135	COG4133	protoheme IX ABC transporter activity
NHAM_RS02140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHAM_RS02145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHAM_RS02155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHAM_RS02170	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS02175	COG1132	(ABC) transporter
NHAM_RS02200	COG0069	glutamate synthase activity
NHAM_RS02225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHAM_RS02230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHAM_RS02240	COG2003	Belongs to the UPF0758 family
NHAM_RS02245	COG0024	Methionine aminopeptidase
NHAM_RS02250	COG3263	regulation of cellular component size
NHAM_RS02255	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NHAM_RS02260	COG4149	molybdate abc transporter
NHAM_RS02265	COG0725	ABC transporter, periplasmic molybdate-binding protein
NHAM_RS02275	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NHAM_RS02280	COG0481	GTPase activity
NHAM_RS02285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHAM_RS02290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHAM_RS02290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHAM_RS02295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NHAM_RS02300	COG2205	protein histidine kinase activity
NHAM_RS02305	COG0745	RESPONSE REGULATOR receiver
NHAM_RS02315	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NHAM_RS02335	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NHAM_RS02340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NHAM_RS02345	COG1280	lysine exporter protein (LysE YggA)
NHAM_RS02350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHAM_RS02350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHAM_RS02360	COG1643	Atp-dependent helicase
NHAM_RS02365	COG1285	pathogenesis
NHAM_RS02370	COG3577	Aspartyl protease
NHAM_RS02375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHAM_RS02380	COG1522	sequence-specific DNA binding
NHAM_RS02385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NHAM_RS02385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NHAM_RS02395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NHAM_RS02400	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NHAM_RS02405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NHAM_RS02415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHAM_RS02430	COG2890	protein-(glutamine-N5) methyltransferase activity
NHAM_RS02435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NHAM_RS02455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHAM_RS02480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NHAM_RS02485	COG1040	competence protein
NHAM_RS02490	COG2226	methyltransferase
NHAM_RS02500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NHAM_RS02505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHAM_RS02510	COG0653	protein targeting
NHAM_RS02515	COG3034	peptidoglycan biosynthetic process
NHAM_RS02520	COG0825	malonyl-CoA metabolic process
NHAM_RS02525	COG4974	Belongs to the 'phage' integrase family
NHAM_RS02535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NHAM_RS02540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NHAM_RS02545	COG1253	flavin adenine dinucleotide binding
NHAM_RS02600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NHAM_RS02620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NHAM_RS02670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NHAM_RS02675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NHAM_RS02685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NHAM_RS02690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NHAM_RS02700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NHAM_RS02705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NHAM_RS02715	COG0799	negative regulation of ribosome biogenesis
NHAM_RS02720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NHAM_RS02730	COG0793	Belongs to the peptidase S41A family
NHAM_RS02740	COG0494	nUDIX hydrolase
NHAM_RS02750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NHAM_RS02755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NHAM_RS02760	COG1764	response to oxidative stress
NHAM_RS02765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NHAM_RS02770	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NHAM_RS02775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NHAM_RS02780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NHAM_RS02790	COG4974	Belongs to the 'phage' integrase family
NHAM_RS02795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHAM_RS02810	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHAM_RS02825	COG0045	succinate-CoA ligase (ADP-forming) activity
NHAM_RS02830	COG0039	L-malate dehydrogenase activity
NHAM_RS02835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NHAM_RS02840	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NHAM_RS02845	COG2755	lipolytic protein G-D-S-L family
NHAM_RS02850	COG4181	ATPase activity
NHAM_RS02855	COG0577	efflux transmembrane transporter activity
NHAM_RS02855	COG1136	(ABC) transporter
NHAM_RS02860	COG0670	Belongs to the BI1 family
NHAM_RS02870	COG1793	dna ligase
NHAM_RS02880	COG0167	dihydroorotate dehydrogenase activity
NHAM_RS02895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHAM_RS02905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NHAM_RS02910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NHAM_RS02915	COG0181	hydroxymethylbilane synthase activity
NHAM_RS02980	COG1192	Involved in chromosome partitioning
NHAM_RS02990	COG4227	nucleotidyltransferase activity
NHAM_RS03005	COG3093	addiction module antidote protein HigA
NHAM_RS03045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS03125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NHAM_RS03145	COG4221	oxidoreductase activity
NHAM_RS03160	COG1872	DUF167
NHAM_RS03165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NHAM_RS03170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NHAM_RS03175	COG1247	-acetyltransferase
NHAM_RS03190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NHAM_RS03210	COG0735	belongs to the Fur family
NHAM_RS03220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NHAM_RS03235	COG0142	geranyltranstransferase activity
NHAM_RS03240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHAM_RS03245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NHAM_RS03260	COG3300	MHYT domain
NHAM_RS03260	COG5001	Diguanylate cyclase
NHAM_RS03295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NHAM_RS03300	COG0573	inorganic phosphate transmembrane transporter activity
NHAM_RS03305	COG0581	inorganic phosphate transmembrane transporter activity
NHAM_RS03310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NHAM_RS03315	COG0704	Plays a role in the regulation of phosphate uptake
NHAM_RS03320	COG0745	RESPONSE REGULATOR receiver
NHAM_RS03330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHAM_RS03335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NHAM_RS03340	COG1217	gtp-binding protein TYPA
NHAM_RS03350	COG0784	Response regulator, receiver
NHAM_RS03365	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NHAM_RS03410	COG0739	heme binding
NHAM_RS03460	COG2204	response regulator
NHAM_RS03470	COG2884	Cell division ATP-binding protein ftsE
NHAM_RS03500	COG0287	Prephenate dehydrogenase
NHAM_RS03505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NHAM_RS03515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NHAM_RS03520	COG2813	Specifically methylates the guanine in position
NHAM_RS03520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NHAM_RS03535	COG0542	response to heat
NHAM_RS03540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NHAM_RS03545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHAM_RS03550	COG0626	cystathionine gamma-synthase activity
NHAM_RS03560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NHAM_RS03565	COG2204	response regulator
NHAM_RS03570	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHAM_RS03580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHAM_RS03585	COG1766	The M ring may be actively involved in energy transduction
NHAM_RS03595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NHAM_RS03605	COG0482	sulfurtransferase activity
NHAM_RS03680	COG1902	pentaerythritol trinitrate reductase activity
NHAM_RS03710	COG0477	Major facilitator Superfamily
NHAM_RS03725	COG1131	(ABC) transporter
NHAM_RS03730	COG0842	Transport permease protein
NHAM_RS03775	COG0811	peptide transport
NHAM_RS03780	COG0848	biopolymer transport protein
NHAM_RS03805	COG3166	PFAM Fimbrial assembly family protein
NHAM_RS03835	COG1459	type II secretion system
NHAM_RS03840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHAM_RS03845	COG1450	Type ii and iii secretion system protein
NHAM_RS03875	COG0848	biopolymer transport protein
NHAM_RS03890	COG0475	glutathione-regulated potassium exporter activity
NHAM_RS03890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NHAM_RS03895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NHAM_RS03895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NHAM_RS03900	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS03915	COG0583	DNA-binding transcription factor activity
NHAM_RS03930	COG0318	PFAM AMP-dependent synthetase and ligase
NHAM_RS03945	COG0598	Magnesium transport protein CorA
NHAM_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
NHAM_RS03960	COG0259	pyridoxamine-phosphate oxidase activity
NHAM_RS03980	COG0406	alpha-ribazole phosphatase activity
NHAM_RS03985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NHAM_RS03990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NHAM_RS03995	COG0840	transmembrane signaling receptor activity
NHAM_RS04015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NHAM_RS04020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NHAM_RS04025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NHAM_RS04030	COG1722	exodeoxyribonuclease VII activity
NHAM_RS04035	COG0123	including yeast histone deacetylase and acetoin utilization protein
NHAM_RS04040	COG1024	Enoyl-CoA hydratase
NHAM_RS04045	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS04195	COG1278	Cold shock
NHAM_RS04320	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHAM_RS04445	COG4974	Belongs to the 'phage' integrase family
NHAM_RS04465	COG0628	permease
NHAM_RS04480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NHAM_RS04485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NHAM_RS04490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NHAM_RS04495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NHAM_RS04510	COG4566	intracellular signal transduction
NHAM_RS04570	COG4191	Histidine kinase
NHAM_RS04585	COG1882	Formate acetyltransferase
NHAM_RS04590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHAM_RS04595	COG0569	domain protein
NHAM_RS04595	COG2985	domain, Protein
NHAM_RS04600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NHAM_RS04660	COG0577	efflux transmembrane transporter activity
NHAM_RS04660	COG1136	(ABC) transporter
NHAM_RS04665	COG1136	(ABC) transporter
NHAM_RS04665	COG0577	efflux transmembrane transporter activity
NHAM_RS04705	COG0783	Belongs to the Dps family
NHAM_RS04710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NHAM_RS04735	COG0625	glutathione transferase activity
NHAM_RS04740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NHAM_RS04765	COG0179	Fumarylacetoacetate (FAA) hydrolase
NHAM_RS04770	COG3396	Phenylacetate-CoA oxygenase
NHAM_RS04775	COG3460	Phenylacetate-CoA oxygenase
NHAM_RS04780	COG3396	Phenylacetate-CoA oxygenase
NHAM_RS04785	COG2151	metal-sulfur cluster biosynthetic enzyme
NHAM_RS04790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NHAM_RS04800	COG2030	dehydratase
NHAM_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
NHAM_RS04815	COG2050	protein possibly involved in aromatic compounds catabolism
NHAM_RS04820	COG1024	Enoyl-CoA hydratase
NHAM_RS04830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHAM_RS04855	COG0450	alkyl hydroperoxide reductase
NHAM_RS04880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHAM_RS04890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHAM_RS04895	COG1120	ATPase activity
NHAM_RS04910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHAM_RS04915	COG3916	Acyl-homoserine-lactone synthase
NHAM_RS04940	COG1136	(ABC) transporter
NHAM_RS04985	COG2719	SpoVR family
NHAM_RS04990	COG2718	Belongs to the UPF0229 family
NHAM_RS04995	COG2766	serine protein kinase
NHAM_RS05015	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NHAM_RS05020	COG0477	Major facilitator Superfamily
NHAM_RS05030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NHAM_RS05065	COG0084	hydrolase, TatD family'
NHAM_RS05085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NHAM_RS05090	COG0642	Histidine kinase
NHAM_RS05125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NHAM_RS05130	COG1320	monovalent cation:proton antiporter activity
NHAM_RS05135	COG2212	antiporter activity
NHAM_RS05140	COG1863	multisubunit Na H antiporter MnhE subunit
NHAM_RS05145	COG0651	ATP synthesis coupled electron transport
NHAM_RS05150	COG1006	Multisubunit Na H antiporter MnhC subunit
NHAM_RS05155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NHAM_RS05155	COG2111	Na H antiporter
NHAM_RS05220	COG0644	oxidoreductase
NHAM_RS05240	COG4774	siderophore transport
NHAM_RS05260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS05265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS05290	COG0443	Heat shock 70 kDa protein
NHAM_RS05295	COG2183	response to ionizing radiation
NHAM_RS05305	COG2080	2 iron, 2 sulfur cluster binding
NHAM_RS05310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NHAM_RS05315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NHAM_RS05320	COG0583	DNA-binding transcription factor activity
NHAM_RS05355	COG2274	protein secretion by the type I secretion system
NHAM_RS05360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS05375	COG1216	Glycosyl transferase, family 2
NHAM_RS05385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHAM_RS05410	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS05410	COG1216	Glycosyl transferase, family 2
NHAM_RS05430	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS05435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NHAM_RS05460	COG2116	formate transmembrane transporter activity
NHAM_RS05475	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NHAM_RS05475	COG1618	nucleotide phosphatase activity, acting on free nucleotides
NHAM_RS05490	COG2900	Belongs to the SlyX family
NHAM_RS05495	COG1054	Belongs to the UPF0176 family
NHAM_RS05535	COG0183	Belongs to the thiolase family
NHAM_RS05540	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHAM_RS05540	COG1024	Enoyl-CoA hydratase
NHAM_RS05595	COG2224	Isocitrate lyase
NHAM_RS05610	COG2133	pyrroloquinoline quinone binding
NHAM_RS05630	COG0436	Aminotransferase
NHAM_RS05645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NHAM_RS05655	COG0659	secondary active sulfate transmembrane transporter activity
NHAM_RS05660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NHAM_RS05675	COG1304	FMN binding
NHAM_RS05685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHAM_RS05690	COG2223	nitrite transmembrane transporter activity
NHAM_RS05705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NHAM_RS05710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NHAM_RS05730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NHAM_RS05755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHAM_RS05760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHAM_RS05770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NHAM_RS05775	COG2951	lytic endotransglycosylase activity
NHAM_RS05805	COG0069	glutamate synthase activity
NHAM_RS05805	COG0067	glutamate synthase
NHAM_RS05805	COG0070	glutamate synthase
NHAM_RS05815	COG0071	Belongs to the small heat shock protein (HSP20) family
NHAM_RS05825	COG0483	inositol monophosphate 1-phosphatase activity
NHAM_RS05875	COG1204	response to ionizing radiation
NHAM_RS05970	COG3239	Fatty acid desaturase
NHAM_RS05975	COG0459	protein refolding
NHAM_RS05980	COG0649	NAD binding
NHAM_RS05995	COG3415	Transposase
NHAM_RS06000	COG0459	protein refolding
NHAM_RS06005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NHAM_RS06010	COG5425	PFAM Usg family protein
NHAM_RS06025	COG2010	Cytochrome c
NHAM_RS06025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NHAM_RS06030	COG2080	2 iron, 2 sulfur cluster binding
NHAM_RS06035	COG2010	Cytochrome c
NHAM_RS06035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NHAM_RS06040	COG5410	chromosome segregation
NHAM_RS06055	COG3293	Transposase
NHAM_RS06090	COG1086	Polysaccharide biosynthesis protein
NHAM_RS06095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NHAM_RS06105	COG2089	acid synthase
NHAM_RS06135	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NHAM_RS06165	COG3842	ATPase activity
NHAM_RS06175	COG0395	ABC-type sugar transport system, permease component
NHAM_RS06210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NHAM_RS06225	COG0469	pyruvate kinase activity
NHAM_RS06240	COG3750	Belongs to the UPF0335 family
NHAM_RS06260	COG1164	Oligoendopeptidase f
NHAM_RS06290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NHAM_RS06295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NHAM_RS06300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NHAM_RS06310	COG5001	Diguanylate cyclase
NHAM_RS06310	COG5002	protein histidine kinase activity
NHAM_RS06310	COG3447	MASE1 domain protein
NHAM_RS06330	COG5001	Diguanylate cyclase
NHAM_RS06330	COG3300	MHYT domain
NHAM_RS06340	COG1176	ABC-type spermidine putrescine transport system, permease component I
NHAM_RS06345	COG1177	transmembrane transport
NHAM_RS06370	COG2205	protein histidine kinase activity
NHAM_RS06480	COG3023	N-Acetylmuramoyl-L-alanine amidase
NHAM_RS06485	COG0275	rRNA processing
NHAM_RS06500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NHAM_RS06510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHAM_RS06515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NHAM_RS06525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NHAM_RS06530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NHAM_RS06540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NHAM_RS06545	COG1181	Belongs to the D-alanine--D-alanine ligase family
NHAM_RS06550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NHAM_RS06555	COG0849	cell division
NHAM_RS06560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NHAM_RS06575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHAM_RS06585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NHAM_RS06595	COG1132	(ABC) transporter
NHAM_RS06605	COG0859	PFAM glycosyl transferase family 9
NHAM_RS06610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NHAM_RS06615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NHAM_RS06620	COG0859	PFAM glycosyl transferase family 9
NHAM_RS06630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NHAM_RS06630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NHAM_RS06655	COG0673	inositol 2-dehydrogenase activity
NHAM_RS06665	COG0728	peptidoglycan biosynthetic process
NHAM_RS06685	COG0351	phosphomethylpyrimidine kinase
NHAM_RS06695	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS06705	COG4948	Mandelate Racemase Muconate Lactonizing
NHAM_RS06710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NHAM_RS06715	COG1127	ABC transporter
NHAM_RS06720	COG3218	ABC-type transport auxiliary lipoprotein component
NHAM_RS06720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NHAM_RS06735	COG0633	Ferredoxin
NHAM_RS06740	COG0492	ferredoxin-NADP+ reductase activity
NHAM_RS06790	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NHAM_RS06790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHAM_RS06795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHAM_RS06800	COG1749	Flagellar hook protein flgE
NHAM_RS06820	COG5443	negative regulation of bacterial-type flagellum assembly
NHAM_RS06865	COG1706	bacterial-type flagellum-dependent cell motility
NHAM_RS06905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHAM_RS06955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHAM_RS07015	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHAM_RS07030	COG3328	transposase activity
NHAM_RS07040	COG3328	transposase activity
NHAM_RS07060	COG4786	Flagellar basal body rod
NHAM_RS07065	COG4786	Flagellar basal body rod
NHAM_RS07095	COG1338	Plays a role in the flagellum-specific transport system
NHAM_RS07110	COG1558	bacterial-type flagellum-dependent cell motility
NHAM_RS07115	COG1677	Flagellar hook-basal body complex protein FliE
NHAM_RS07120	COG1987	bacterial-type flagellum assembly
NHAM_RS07125	COG1684	flagellar biosynthetic protein fliR
NHAM_RS07130	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHAM_RS07165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NHAM_RS07170	COG2983	Belongs to the UPF0260 family
NHAM_RS07175	COG0477	Major facilitator Superfamily
NHAM_RS07205	COG4695	Portal protein
NHAM_RS07340	COG4235	cytochrome complex assembly
NHAM_RS07345	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NHAM_RS07350	COG1138	Cytochrome C-type biogenesis protein
NHAM_RS07355	COG3088	subunit of a heme lyase
NHAM_RS07365	COG0745	RESPONSE REGULATOR receiver
NHAM_RS07370	COG3474	cytochrome
NHAM_RS07395	COG2205	protein histidine kinase activity
NHAM_RS07400	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NHAM_RS07405	COG2202	Pas domain
NHAM_RS07405	COG2205	protein histidine kinase activity
NHAM_RS07455	COG2151	metal-sulfur cluster biosynthetic enzyme
NHAM_RS07460	COG0058	SHG alpha-glucan phosphorylase activity
NHAM_RS07470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NHAM_RS07480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NHAM_RS07485	COG0366	Alpha amylase catalytic
NHAM_RS07490	COG0366	Alpha amylase catalytic
NHAM_RS07495	COG1640	4-alpha-glucanotransferase
NHAM_RS07505	COG2202	Pas domain
NHAM_RS07505	COG2205	protein histidine kinase activity
NHAM_RS07510	COG2084	Dehydrogenase
NHAM_RS07530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NHAM_RS07545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NHAM_RS07555	COG0546	phosphoglycolate phosphatase activity
NHAM_RS07560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NHAM_RS07575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NHAM_RS07580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NHAM_RS07605	COG0215	cysteine-tRNA ligase activity
NHAM_RS07620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHAM_RS07630	COG5265	(ABC) transporter
NHAM_RS07635	COG0688	phosphatidylethanolamine metabolic process
NHAM_RS07645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHAM_RS07655	COG3158	transport of potassium into the cell
NHAM_RS07670	COG0436	Aminotransferase
NHAM_RS07675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NHAM_RS07685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHAM_RS07690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHAM_RS07695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHAM_RS07700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHAM_RS07745	COG4774	siderophore transport
NHAM_RS07750	COG3128	pkhd-type hydroxylase
NHAM_RS07760	COG0848	biopolymer transport protein
NHAM_RS07775	COG1994	Peptidase M50
NHAM_RS07820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NHAM_RS07825	COG0081	regulation of translation
NHAM_RS07830	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NHAM_RS07835	COG0222	ribosome binding
NHAM_RS07845	COG0085	RNA polymerase activity
NHAM_RS07850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NHAM_RS07855	COG1231	oxidoreductase activity
NHAM_RS07860	COG1132	(ABC) transporter
NHAM_RS07885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NHAM_RS07890	COG0049	tRNA binding
NHAM_RS07895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NHAM_RS07900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NHAM_RS07905	COG0051	transcription antitermination factor activity, RNA binding
NHAM_RS07910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NHAM_RS07915	COG0088	Forms part of the polypeptide exit tunnel
NHAM_RS07920	COG0089	rRNA binding
NHAM_RS07925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NHAM_RS07930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NHAM_RS07935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NHAM_RS07940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NHAM_RS07945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NHAM_RS07950	COG0255	Belongs to the universal ribosomal protein uL29 family
NHAM_RS07955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NHAM_RS07960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NHAM_RS07965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NHAM_RS07970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NHAM_RS07975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NHAM_RS07980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NHAM_RS07985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NHAM_RS07990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NHAM_RS07995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NHAM_RS08000	COG1841	ribosomal large subunit assembly
NHAM_RS08005	COG0200	Binds to the 23S rRNA
NHAM_RS08010	COG0201	protein transport
NHAM_RS08015	COG0563	adenylate kinase activity
NHAM_RS08020	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NHAM_RS08025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NHAM_RS08030	COG0202	RNA polymerase activity
NHAM_RS08035	COG0203	ribosomal protein L17
NHAM_RS08050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NHAM_RS08075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHAM_RS08080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NHAM_RS08085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHAM_RS08090	COG1252	NADH dehydrogenase
NHAM_RS08110	COG0416	fatty acid biosynthetic process
NHAM_RS08115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHAM_RS08120	COG0776	regulation of translation
NHAM_RS08220	COG4397	Mu-like prophage major head subunit gpT
NHAM_RS08265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NHAM_RS08270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHAM_RS08270	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NHAM_RS08275	COG0509	glycine decarboxylation via glycine cleavage system
NHAM_RS08280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NHAM_RS08285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHAM_RS08295	COG0538	isocitrate dehydrogenase activity
NHAM_RS08335	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NHAM_RS08345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NHAM_RS08350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHAM_RS08355	COG0047	phosphoribosylformylglycinamidine synthase activity
NHAM_RS08360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NHAM_RS08375	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NHAM_RS08380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NHAM_RS08385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NHAM_RS08395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NHAM_RS08400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NHAM_RS08425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHAM_RS08425	COG0617	tRNA 3'-terminal CCA addition
NHAM_RS08425	COG0517	IMP dehydrogenase activity
NHAM_RS08430	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHAM_RS08450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NHAM_RS08465	COG0302	gtp cyclohydrolase
NHAM_RS08470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NHAM_RS08490	COG2201	protein-glutamate methylesterase activity
NHAM_RS08495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NHAM_RS08525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHAM_RS08535	COG1393	Belongs to the ArsC family
NHAM_RS08555	COG0559	Belongs to the binding-protein-dependent transport system permease family
NHAM_RS08560	COG4214	carbohydrate transport
NHAM_RS08565	COG1392	Phosphate transport regulator
NHAM_RS08570	COG0306	phosphate transporter
NHAM_RS08595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NHAM_RS08610	COG1160	GTP binding
NHAM_RS08615	COG0300	oxidoreductase activity
NHAM_RS08620	COG0284	orotidine-5'-phosphate decarboxylase activity
NHAM_RS08650	COG0052	Belongs to the universal ribosomal protein uS2 family
NHAM_RS08655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NHAM_RS08660	COG0528	UMP kinase activity
NHAM_RS08665	COG0233	cytoplasmic translational termination
NHAM_RS08670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NHAM_RS08680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NHAM_RS08685	COG0750	zinc metalloprotease
NHAM_RS08690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NHAM_RS08695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHAM_RS08700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHAM_RS08705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHAM_RS08715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NHAM_RS08720	COG0372	Belongs to the citrate synthase family
NHAM_RS08725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHAM_RS08730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHAM_RS08840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NHAM_RS08845	COG0303	'Molybdopterin
NHAM_RS08855	COG0315	cyclic pyranopterin monophosphate synthase activity
NHAM_RS08860	COG0134	indole-3-glycerol-phosphate synthase activity
NHAM_RS08865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NHAM_RS08870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHAM_RS08875	COG0149	triose-phosphate isomerase activity
NHAM_RS08885	COG0504	CTP synthase activity
NHAM_RS08890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NHAM_RS08905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NHAM_RS08910	COG0148	phosphopyruvate hydratase activity
NHAM_RS08930	COG0431	NADPH-dependent FMN reductase
NHAM_RS08940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NHAM_RS08945	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHAM_RS08945	COG0022	dehydrogenase e1 component
NHAM_RS08950	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHAM_RS08955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHAM_RS08960	COG0129	dihydroxy-acid dehydratase activity
NHAM_RS08965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NHAM_RS08980	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NHAM_RS08985	COG0018	arginyl-trna synthetase
NHAM_RS08995	COG1472	Belongs to the glycosyl hydrolase 3 family
NHAM_RS09000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NHAM_RS09005	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NHAM_RS09010	COG2095	MarC family integral membrane protein
NHAM_RS09015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHAM_RS09025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NHAM_RS09045	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NHAM_RS09050	COG0343	queuine tRNA-ribosyltransferase activity
NHAM_RS09120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NHAM_RS09140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NHAM_RS09145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHAM_RS09150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NHAM_RS09155	COG0805	protein transport
NHAM_RS09160	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NHAM_RS09165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NHAM_RS09175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NHAM_RS09195	COG1862	Preprotein translocase
NHAM_RS09200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHAM_RS09225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NHAM_RS09280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NHAM_RS09285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHAM_RS09290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHAM_RS09290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHAM_RS09300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NHAM_RS09305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHAM_RS09310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NHAM_RS09320	COG1530	ribonuclease E activity
NHAM_RS09320	COG1530	ribonuclease E activity
NHAM_RS09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHAM_RS09330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NHAM_RS09355	COG0525	valine-tRNA ligase activity
NHAM_RS09365	COG2094	Belongs to the DNA glycosylase MPG family
NHAM_RS09370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NHAM_RS09375	COG2867	negative regulation of translational initiation
NHAM_RS09380	COG1058	Belongs to the CinA family
NHAM_RS09380	COG1546	Belongs to the CinA family
NHAM_RS09385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NHAM_RS09385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NHAM_RS09405	COG5000	phosphorelay sensor kinase activity
NHAM_RS09410	COG2204	response regulator
NHAM_RS09415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHAM_RS09420	COG1923	regulation of RNA biosynthetic process
NHAM_RS09425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NHAM_RS09435	COG3956	TIGRFAM MazG family protein
NHAM_RS09440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NHAM_RS09480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS09515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NHAM_RS09600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS09605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS09680	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NHAM_RS09695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NHAM_RS09700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NHAM_RS09705	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NHAM_RS09710	COG3174	membrane
NHAM_RS09715	COG0517	IMP dehydrogenase activity
NHAM_RS09715	COG1125	glycine betaine transport
NHAM_RS09730	COG4566	intracellular signal transduction
NHAM_RS09735	COG4191	Histidine kinase
NHAM_RS09780	COG0071	Belongs to the small heat shock protein (HSP20) family
NHAM_RS09785	COG0517	IMP dehydrogenase activity
NHAM_RS09785	COG0516	GMP reductase activity
NHAM_RS09790	COG1042	CoA-binding domain protein
NHAM_RS09790	COG0045	succinate-CoA ligase (ADP-forming) activity
NHAM_RS09790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHAM_RS09800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NHAM_RS09805	COG1127	ABC transporter
NHAM_RS09810	COG3218	ABC-type transport auxiliary lipoprotein component
NHAM_RS09810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NHAM_RS09840	COG1063	alcohol dehydrogenase
NHAM_RS09845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NHAM_RS09855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NHAM_RS09860	COG0617	tRNA 3'-terminal CCA addition
NHAM_RS09860	COG0517	IMP dehydrogenase activity
NHAM_RS09860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHAM_RS09895	COG3038	cytochrome b561
NHAM_RS09910	COG2010	Cytochrome c
NHAM_RS09920	COG0516	GMP reductase activity
NHAM_RS09920	COG0517	IMP dehydrogenase activity
NHAM_RS09965	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS09985	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS10045	COG4249	Peptidase C14 caspase catalytic subunit p20
NHAM_RS10125	COG0556	nucleotide-excision repair
NHAM_RS10135	COG0406	alpha-ribazole phosphatase activity
NHAM_RS10135	COG0494	nUDIX hydrolase
NHAM_RS10175	COG1074	ATP-dependent DNA helicase activity
NHAM_RS10180	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS10205	COG1742	UPF0060 membrane protein
NHAM_RS10210	COG0318	PFAM AMP-dependent synthetase and ligase
NHAM_RS10215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NHAM_RS10215	COG0321	lipoyl(octanoyl) transferase activity
NHAM_RS10220	COG0084	hydrolase, TatD family'
NHAM_RS10225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHAM_RS10235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NHAM_RS10240	COG1686	Belongs to the peptidase S11 family
NHAM_RS10245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NHAM_RS10260	COG0582	viral genome integration into host DNA
NHAM_RS10365	COG1278	Cold shock
NHAM_RS10400	COG1984	allophanate hydrolase subunit 2
NHAM_RS10405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NHAM_RS10415	COG1253	flavin adenine dinucleotide binding
NHAM_RS10420	COG1183	phosphatidylcholine synthase activity
NHAM_RS10425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHAM_RS10455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NHAM_RS10465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NHAM_RS10475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NHAM_RS10505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS10510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS10525	COG1126	abc transporter atp-binding protein
NHAM_RS10530	COG0765	amino acid transport
NHAM_RS10535	COG4597	amino acid ABC transporter
NHAM_RS10540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHAM_RS10545	COG0626	cystathionine gamma-synthase activity
NHAM_RS10550	COG1283	sodium-dependent phosphate transmembrane transporter activity
NHAM_RS10560	COG0463	Glycosyl transferase, family 2
NHAM_RS10565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NHAM_RS10570	COG4953	penicillin-binding protein 1C
NHAM_RS10575	COG2373	Large extracellular alpha-helical protein
NHAM_RS10585	COG0629	single-stranded DNA binding
NHAM_RS10595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NHAM_RS10605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHAM_RS10675	COG0625	glutathione transferase activity
NHAM_RS10685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHAM_RS10705	COG3045	CreA protein
NHAM_RS10730	COG0280	phosphate acetyltransferase
NHAM_RS10730	COG0281	malic enzyme
NHAM_RS10735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NHAM_RS10740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NHAM_RS10745	COG0723	plastoquinol--plastocyanin reductase activity
NHAM_RS10755	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NHAM_RS10770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NHAM_RS10775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NHAM_RS10780	COG1278	Cold shock
NHAM_RS10785	COG0861	Integral membrane protein TerC family
NHAM_RS10790	COG0105	UTP biosynthetic process
NHAM_RS10805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NHAM_RS10815	COG2192	nodulation
NHAM_RS10895	COG1278	Cold shock
NHAM_RS10930	COG1278	Cold shock
NHAM_RS11005	COG0671	phosphoesterase, PA-phosphatase related
NHAM_RS11020	COG0321	lipoyl(octanoyl) transferase activity
NHAM_RS11025	COG1254	Belongs to the acylphosphatase family
NHAM_RS11030	COG4770	biotin carboxylase activity
NHAM_RS11040	COG0450	alkyl hydroperoxide reductase
NHAM_RS11045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NHAM_RS11115	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NHAM_RS11120	COG0436	Aminotransferase
NHAM_RS11135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NHAM_RS11140	COG0511	ligase activity, forming carbon-carbon bonds
NHAM_RS11150	COG4191	Histidine kinase
NHAM_RS11155	COG0784	Response regulator, receiver
NHAM_RS11160	COG0745	RESPONSE REGULATOR receiver
NHAM_RS11165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NHAM_RS11170	COG1136	(ABC) transporter
NHAM_RS11180	COG0442	prolyl-tRNA aminoacylation
NHAM_RS11200	COG4772	TonB-dependent receptor
NHAM_RS11215	COG0346	lactoylglutathione lyase activity
NHAM_RS11230	COG1007	ATP synthesis coupled electron transport
NHAM_RS11245	COG0713	ATP synthesis coupled electron transport
NHAM_RS11255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHAM_RS11260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NHAM_RS11270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NHAM_RS11275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NHAM_RS11285	COG0649	NAD binding
NHAM_RS11290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHAM_RS11295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHAM_RS11315	COG0776	regulation of translation
NHAM_RS11320	COG2195	Cleaves the N-terminal amino acid of tripeptides
NHAM_RS11330	COG2226	methyltransferase
NHAM_RS11345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHAM_RS11350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NHAM_RS11355	COG0740	serine-type endopeptidase activity
NHAM_RS11360	COG0544	peptidyl-prolyl cis-trans isomerase activity
NHAM_RS11375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NHAM_RS11375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NHAM_RS11380	COG0347	Belongs to the P(II) protein family
NHAM_RS11385	COG0174	glutamine synthetase
NHAM_RS11415	COG0113	porphobilinogen synthase activity
NHAM_RS11425	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NHAM_RS11430	COG1914	H( )-stimulated, divalent metal cation uptake system
NHAM_RS11435	COG1393	Belongs to the ArsC family
NHAM_RS11440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NHAM_RS11450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHAM_RS11455	COG1381	Involved in DNA repair and RecF pathway recombination
NHAM_RS11465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NHAM_RS11470	COG0571	ribonuclease III activity
NHAM_RS11475	COG0681	Belongs to the peptidase S26 family
NHAM_RS11480	COG0736	holo-[acyl-carrier-protein] synthase activity
NHAM_RS11485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NHAM_RS11495	COG1758	RNA polymerase activity
NHAM_RS11505	COG1573	uracil-dna glycosylase
NHAM_RS11515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NHAM_RS11520	COG1970	mechanosensitive ion channel activity
NHAM_RS11525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHAM_RS11545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NHAM_RS11565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NHAM_RS11575	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS11590	COG0154	amidase activity
NHAM_RS11600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NHAM_RS11605	COG2070	2-Nitropropane dioxygenase
NHAM_RS11610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NHAM_RS11620	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS11625	COG0540	Belongs to the ATCase OTCase family
NHAM_RS11630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NHAM_RS11635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NHAM_RS11640	COG0758	DNA mediated transformation
NHAM_RS11655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NHAM_RS11665	COG0305	Participates in initiation and elongation during chromosome replication
NHAM_RS11670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHAM_RS11680	COG1286	toxin biosynthetic process
NHAM_RS11685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NHAM_RS11725	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NHAM_RS11730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NHAM_RS11750	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS11760	COG1494	fructose-1,6-bisphosphatase
NHAM_RS11770	COG0436	Aminotransferase
NHAM_RS11780	COG3243	poly(R)-hydroxyalkanoic acid synthase
NHAM_RS11805	COG0187	DNA topoisomerase II activity
NHAM_RS11825	COG0513	Belongs to the DEAD box helicase family
NHAM_RS11835	COG0316	Belongs to the HesB IscA family
NHAM_RS11845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NHAM_RS11850	COG0719	Fe-S assembly protein
NHAM_RS11855	COG0396	ATPase activity
NHAM_RS11860	COG0719	Fe-S assembly protein
NHAM_RS11865	COG1104	cysteine desulfurase activity
NHAM_RS11870	COG2945	thiolester hydrolase activity
NHAM_RS11875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NHAM_RS11880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHAM_RS11895	COG0739	heme binding
NHAM_RS11905	COG0488	(ABC) transporter
NHAM_RS11920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NHAM_RS11945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NHAM_RS11950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NHAM_RS11955	COG1063	alcohol dehydrogenase
NHAM_RS11965	COG0194	GDP metabolic process
NHAM_RS11970	COG1561	YicC-like family, N-terminal region
NHAM_RS11975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NHAM_RS11980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHAM_RS11985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHAM_RS11995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NHAM_RS12000	COG0360	Binds together with S18 to 16S ribosomal RNA
NHAM_RS12005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NHAM_RS12195	COG0740	serine-type endopeptidase activity
NHAM_RS12330	COG0359	binds to the 23S rRNA
NHAM_RS12340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NHAM_RS12355	COG1686	Belongs to the peptidase S11 family
NHAM_RS12370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NHAM_RS12415	COG0656	L-ascorbic acid biosynthetic process
NHAM_RS12440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHAM_RS12445	COG0557	exoribonuclease II activity
NHAM_RS12460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NHAM_RS12470	COG0784	Response regulator, receiver
NHAM_RS12480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NHAM_RS12510	COG0537	adenosine 5'-monophosphoramidase activity
NHAM_RS12515	COG1720	tRNA m6t6A37 methyltransferase activity
NHAM_RS12525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NHAM_RS12530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NHAM_RS12555	COG1612	heme a metabolic process
NHAM_RS12580	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS12595	COG3268	Saccharopine dehydrogenase
NHAM_RS12750	COG0582	viral genome integration into host DNA
NHAM_RS12810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHAM_RS12935	COG3459	Glycosyltransferase 36 associated
NHAM_RS12945	COG1278	Cold shock
NHAM_RS12960	COG1063	alcohol dehydrogenase
NHAM_RS12995	COG3239	Fatty acid desaturase
NHAM_RS13000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NHAM_RS13000	COG0519	Catalyzes the synthesis of GMP from XMP
NHAM_RS13035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NHAM_RS13050	COG1671	Belongs to the UPF0178 family
NHAM_RS13055	COG0488	(ABC) transporter
NHAM_RS13060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NHAM_RS13060	COG0493	'glutamate synthase
NHAM_RS13070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHAM_RS13080	COG1024	Enoyl-CoA hydratase
NHAM_RS13085	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS13095	COG0183	Belongs to the thiolase family
NHAM_RS13140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHAM_RS13145	COG3038	cytochrome b561
NHAM_RS13215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHAM_RS13225	COG2309	aminopeptidase activity
NHAM_RS13255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NHAM_RS13260	COG1546	Belongs to the CinA family
NHAM_RS13260	COG1058	Belongs to the CinA family
NHAM_RS13265	COG5425	PFAM Usg family protein
NHAM_RS13270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NHAM_RS13275	COG0459	protein refolding
NHAM_RS13315	COG3608	succinylglutamate desuccinylase aspartoacylase
NHAM_RS13315	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NHAM_RS13350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NHAM_RS13385	COG0785	Cytochrome C biogenesis protein
NHAM_RS13420	COG2205	protein histidine kinase activity
NHAM_RS13435	COG2166	iron-sulfur cluster assembly
NHAM_RS13445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NHAM_RS13450	COG4957	zinc ion binding
NHAM_RS13470	COG0433	COG0433 Predicted ATPase
NHAM_RS13485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NHAM_RS13490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NHAM_RS13495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NHAM_RS13520	COG1703	isobutyryl-CoA mutase activity
NHAM_RS13525	COG0644	oxidoreductase
NHAM_RS13550	COG2814	Major facilitator Superfamily
NHAM_RS13645	COG1024	Enoyl-CoA hydratase
NHAM_RS13650	COG0427	acetyl-CoA hydrolase
NHAM_RS13655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NHAM_RS13670	COG0587	DNA-directed DNA polymerase activity
NHAM_RS13685	COG3685	Protein conserved in bacteria
NHAM_RS13690	COG1473	amidohydrolase
NHAM_RS13705	COG1595	DNA-templated transcription, initiation
NHAM_RS13730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NHAM_RS13745	COG1657	PFAM Prenyltransferase squalene oxidase
NHAM_RS13750	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NHAM_RS13755	COG1562	ergosterol biosynthetic process
NHAM_RS13760	COG1562	ergosterol biosynthetic process
NHAM_RS13790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NHAM_RS13810	COG1309	transcriptional regulator
NHAM_RS13825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHAM_RS13830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS13835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS13840	COG1309	transcriptional regulator
NHAM_RS13845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NHAM_RS13860	COG2301	Belongs to the HpcH HpaI aldolase family
NHAM_RS13865	COG2030	dehydratase
NHAM_RS13875	COG1858	cytochrome C peroxidase
NHAM_RS13890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS13915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHAM_RS13920	COG2326	polyphosphate kinase activity
NHAM_RS13930	COG1125	glycine betaine transport
NHAM_RS13930	COG0517	IMP dehydrogenase activity
NHAM_RS13935	COG1174	glycine betaine transport
NHAM_RS13940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NHAM_RS13945	COG0440	acetolactate synthase activity
NHAM_RS13950	COG0028	Belongs to the TPP enzyme family
NHAM_RS13955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NHAM_RS13960	COG0560	Phosphoserine phosphatase
NHAM_RS13975	COG0330	HflC and HflK could
NHAM_RS13980	COG0330	HflC and HflK could
NHAM_RS13990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NHAM_RS14000	COG0114	fumarate hydratase activity
NHAM_RS14035	COG0210	DNA helicase
NHAM_RS14040	COG1131	(ABC) transporter
NHAM_RS14045	COG0842	Transport permease protein
NHAM_RS14070	COG2264	protein methyltransferase activity
NHAM_RS14075	COG0006	proline dipeptidase activity
NHAM_RS14075	COG0006	proline dipeptidase activity
NHAM_RS14090	COG1278	Cold shock
NHAM_RS14100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NHAM_RS14105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NHAM_RS14115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHAM_RS14175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NHAM_RS14185	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NHAM_RS14195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NHAM_RS14200	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS14205	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS14220	COG0438	transferase activity, transferring glycosyl groups
NHAM_RS14265	COG1484	DNA-dependent DNA replication
NHAM_RS14270	COG4584	PFAM Integrase catalytic
NHAM_RS14280	COG3415	Transposase
NHAM_RS14290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS14295	COG4584	PFAM Integrase catalytic
NHAM_RS14305	COG2433	Pfam Transposase IS66
NHAM_RS14320	COG3328	transposase activity
NHAM_RS14355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHAM_RS14365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NHAM_RS14380	COG0537	adenosine 5'-monophosphoramidase activity
NHAM_RS14405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NHAM_RS14415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHAM_RS14420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NHAM_RS14425	COG0156	8-amino-7-oxononanoate synthase activity
NHAM_RS14445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NHAM_RS14500	COG4717	serine-type aminopeptidase activity
NHAM_RS14505	COG0420	3'-5' exonuclease activity
NHAM_RS14515	COG3177	Filamentation induced by cAMP protein fic
NHAM_RS14535	COG3415	Transposase
NHAM_RS14545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHAM_RS14555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NHAM_RS14580	COG1278	Cold shock
NHAM_RS14635	COG0328	RNA-DNA hybrid ribonuclease activity
NHAM_RS14660	COG0564	pseudouridine synthase activity
NHAM_RS14665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHAM_RS14675	COG2951	lytic endotransglycosylase activity
NHAM_RS14700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHAM_RS14705	COG0358	DNA primase activity
NHAM_RS14720	COG0505	Belongs to the CarA family
NHAM_RS14760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NHAM_RS14765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NHAM_RS14775	COG2259	Doxx family
NHAM_RS14780	COG1522	sequence-specific DNA binding
NHAM_RS14785	COG0492	ferredoxin-NADP+ reductase activity
NHAM_RS14790	COG0583	DNA-binding transcription factor activity
NHAM_RS14795	COG1192	Involved in chromosome partitioning
NHAM_RS14815	COG3360	Dodecin
NHAM_RS14845	COG2022	thiamine diphosphate biosynthetic process
NHAM_RS14860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NHAM_RS14880	COG2391	methyltransferase activity
NHAM_RS14885	COG2204	response regulator
NHAM_RS14925	COG4106	trans-aconitate 2-methyltransferase activity
NHAM_RS14930	COG0628	permease
NHAM_RS14950	COG1376	ErfK ybiS ycfS ynhG family protein
NHAM_RS14960	COG2897	thiosulfate sulfurtransferase activity
NHAM_RS14965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHAM_RS14995	COG0556	nucleotide-excision repair
NHAM_RS15040	COG2199	diguanylate cyclase activity
NHAM_RS15040	COG2200	EAL domain
NHAM_RS15045	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS15055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NHAM_RS15060	COG0425	Belongs to the sulfur carrier protein TusA family
NHAM_RS15065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHAM_RS15090	COG2197	response regulator
NHAM_RS15120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS15130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NHAM_RS15130	COG3608	succinylglutamate desuccinylase aspartoacylase
NHAM_RS15145	COG0528	UMP kinase activity
NHAM_RS15155	COG0528	UMP kinase activity
NHAM_RS15165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NHAM_RS15175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHAM_RS15185	COG2963	transposase activity
NHAM_RS15200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHAM_RS15225	COG0488	(ABC) transporter
NHAM_RS15250	COG3119	arylsulfatase activity
NHAM_RS15255	COG1566	PFAM secretion protein HlyD family protein
NHAM_RS15280	COG3119	arylsulfatase activity
NHAM_RS15295	COG3119	arylsulfatase activity
NHAM_RS15300	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NHAM_RS15320	COG3012	SEC-C Motif Domain Protein
NHAM_RS15325	COG0745	RESPONSE REGULATOR receiver
NHAM_RS15330	COG2205	protein histidine kinase activity
NHAM_RS15335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NHAM_RS15340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NHAM_RS15345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NHAM_RS15355	COG3436	PFAM IS66 Orf2 family protein
NHAM_RS15360	COG2963	transposase activity
NHAM_RS15375	COG2197	response regulator
NHAM_RS15405	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS15410	COG2963	transposase activity
NHAM_RS15415	COG3436	PFAM IS66 Orf2 family protein
NHAM_RS15450	COG3328	transposase activity
NHAM_RS15510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NHAM_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS15520	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
NHAM_RS15565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NHAM_RS15570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHAM_RS15580	COG0110	maltose O-acetyltransferase activity
NHAM_RS15585	COG2244	polysaccharide biosynthetic process
NHAM_RS15595	COG0673	inositol 2-dehydrogenase activity
NHAM_RS15600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NHAM_RS15630	COG2274	protein secretion by the type I secretion system
NHAM_RS15655	COG1091	dTDP-4-dehydrorhamnose reductase activity
NHAM_RS15660	COG1088	dTDP-glucose 4,6-dehydratase activity
NHAM_RS15670	COG0489	protein tyrosine kinase activity
NHAM_RS15670	COG3206	protein involved in exopolysaccharide biosynthesis
NHAM_RS15680	COG3335	DDE superfamily endonuclease
NHAM_RS15685	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS15690	COG4372	Transposase
NHAM_RS15705	COG3335	DDE superfamily endonuclease
NHAM_RS15710	COG3415	Transposase
NHAM_RS15715	COG2433	Pfam Transposase IS66
NHAM_RS15790	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS15815	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS15850	COG3710	Transcriptional regulator
NHAM_RS15850	COG0457	Tetratricopeptide repeat
NHAM_RS15855	COG1525	nuclease
NHAM_RS15860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NHAM_RS15870	COG1496	oxidoreductase activity
NHAM_RS15880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NHAM_RS15900	COG2030	dehydratase
NHAM_RS15910	COG0012	GTP binding
NHAM_RS15915	COG0193	aminoacyl-tRNA hydrolase activity
NHAM_RS15920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NHAM_RS15935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHAM_RS15955	COG1012	belongs to the aldehyde dehydrogenase family
NHAM_RS15960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHAM_RS16035	COG3383	formate dehydrogenase (NAD+) activity
NHAM_RS16040	COG0437	4 iron, 4 sulfur cluster binding
NHAM_RS16050	COG0425	Belongs to the sulfur carrier protein TusA family
NHAM_RS16050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHAM_RS16055	COG0303	'Molybdopterin
NHAM_RS16060	COG1763	Mo-molybdopterin cofactor biosynthetic process
NHAM_RS16070	COG0746	molybdenum cofactor guanylyltransferase activity
NHAM_RS16075	COG0303	'Molybdopterin
NHAM_RS16090	COG0745	RESPONSE REGULATOR receiver
NHAM_RS16095	COG1846	Transcriptional regulator
NHAM_RS16100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHAM_RS16110	COG0534	Mate efflux family protein
NHAM_RS16115	COG2890	protein-(glutamine-N5) methyltransferase activity
NHAM_RS16120	COG0314	molybdopterin synthase activity
NHAM_RS16125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NHAM_RS16130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHAM_RS16135	COG0322	excinuclease ABC activity
NHAM_RS16145	COG1278	Cold shock
NHAM_RS16150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NHAM_RS16190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHAM_RS16205	COG0745	RESPONSE REGULATOR receiver
NHAM_RS16210	COG0196	riboflavin kinase activity
NHAM_RS16215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NHAM_RS16220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NHAM_RS16230	COG0612	Peptidase, M16
NHAM_RS16235	COG0612	Peptidase, M16
NHAM_RS16250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NHAM_RS16255	COG0742	ribosomal rna small subunit methyltransferase
NHAM_RS16260	COG1187	pseudouridine synthase activity
NHAM_RS16265	COG0590	tRNA wobble adenosine to inosine editing
NHAM_RS16270	COG0151	Belongs to the GarS family
NHAM_RS16275	COG1570	exodeoxyribonuclease VII activity
NHAM_RS16290	COG1663	tetraacyldisaccharide 4'-kinase activity
NHAM_RS16295	COG1519	Transferase
NHAM_RS16310	COG0483	inositol monophosphate 1-phosphatase activity
NHAM_RS16315	COG0312	modulator of DNA gyrase
NHAM_RS16325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NHAM_RS16340	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NHAM_RS16345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NHAM_RS16350	COG0463	Glycosyl transferase, family 2
NHAM_RS16360	COG3416	Protein conserved in bacteria
NHAM_RS16365	COG1388	LysM domain
NHAM_RS16365	COG1376	ErfK ybiS ycfS ynhG family protein
NHAM_RS16380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NHAM_RS16385	COG0459	protein refolding
NHAM_RS16410	COG0247	lactate metabolic process
NHAM_RS16415	COG0277	FAD linked oxidase domain protein
NHAM_RS16420	COG0277	FAD linked oxidase domain protein
NHAM_RS16430	COG1309	transcriptional regulator
NHAM_RS16445	COG0751	glycine-tRNA ligase activity
NHAM_RS16450	COG0752	glycyl-tRNA synthetase alpha subunit
NHAM_RS16475	COG0142	geranyltranstransferase activity
NHAM_RS16480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NHAM_RS16495	COG1573	uracil-dna glycosylase
NHAM_RS16505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NHAM_RS16515	COG0521	Mo-molybdopterin cofactor biosynthetic process
NHAM_RS16520	COG2321	neutral zinc metallopeptidase
NHAM_RS16525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NHAM_RS16530	COG0625	glutathione transferase activity
NHAM_RS16545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NHAM_RS16545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NHAM_RS16550	COG1196	nuclear chromosome segregation
NHAM_RS16560	COG2832	Protein of unknown function (DUF454)
NHAM_RS16565	COG1704	LemA family
NHAM_RS16585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NHAM_RS16595	COG1881	PFAM PEBP family protein
NHAM_RS16600	COG2857	Cytochrome c1
NHAM_RS16600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHAM_RS16605	COG0723	plastoquinol--plastocyanin reductase activity
NHAM_RS16610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NHAM_RS16615	COG0602	queuosine metabolic process
NHAM_RS16630	COG0408	coproporphyrinogen oxidase activity
NHAM_RS16655	COG0714	Associated with various cellular activities
NHAM_RS16680	COG3293	Transposase
NHAM_RS16725	COG0590	tRNA wobble adenosine to inosine editing
NHAM_RS16740	COG0386	Belongs to the glutathione peroxidase family
NHAM_RS16750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHAM_RS16755	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NHAM_RS16760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NHAM_RS16765	COG0363	glucosamine-6-phosphate deaminase activity
NHAM_RS16770	COG3265	gluconokinase activity
NHAM_RS16775	COG0561	phosphatase activity
NHAM_RS16780	COG3387	PFAM Glycoside hydrolase 15-related
NHAM_RS16785	COG5001	Diguanylate cyclase
NHAM_RS16790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHAM_RS16805	COG0583	DNA-binding transcription factor activity
NHAM_RS16835	COG1959	2 iron, 2 sulfur cluster binding
NHAM_RS16840	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHAM_RS16850	COG1140	nitrate reductase beta subunit
NHAM_RS16865	COG4774	siderophore transport
NHAM_RS16875	COG0642	Histidine kinase
NHAM_RS16885	COG0745	RESPONSE REGULATOR receiver
NHAM_RS16890	COG1566	PFAM secretion protein HlyD family protein
NHAM_RS16970	COG4974	Belongs to the 'phage' integrase family
NHAM_RS17285	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHAM_RS17315	COG2201	protein-glutamate methylesterase activity
NHAM_RS17320	COG0784	Response regulator, receiver
NHAM_RS17320	COG2198	Histidine kinase
NHAM_RS17320	COG0643	Histidine kinase
NHAM_RS17330	COG2198	Histidine kinase
NHAM_RS17330	COG0643	Histidine kinase
NHAM_RS17340	COG1218	3'(2'),5'-bisphosphate nucleotidase
NHAM_RS17370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NHAM_RS17375	COG0028	Belongs to the TPP enzyme family
NHAM_RS17380	COG1376	ErfK ybiS ycfS ynhG family protein
NHAM_RS17390	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS17395	COG1272	protein, Hemolysin III
NHAM_RS17400	COG3106	COG3106 Predicted ATPase
NHAM_RS17405	COG3768	UPF0283 membrane protein
NHAM_RS17435	COG1278	Cold shock
NHAM_RS17445	COG0506	proline dehydrogenase activity
NHAM_RS17445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NHAM_RS17445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NHAM_RS17460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NHAM_RS17465	COG1704	LemA family
NHAM_RS17470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NHAM_RS17485	COG1960	acyl-CoA dehydrogenase activity
NHAM_RS17490	COG1511	domain protein
NHAM_RS17490	COG3264	Mechanosensitive ion channel
NHAM_RS17495	COG3585	molybdate ion transport
NHAM_RS17495	COG2005	Transcriptional regulator
NHAM_RS17500	COG1618	nucleotide phosphatase activity, acting on free nucleotides
NHAM_RS17500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NHAM_RS17525	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NHAM_RS17535	COG0339	signal peptide processing
NHAM_RS17555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NHAM_RS17575	COG0523	cobalamin synthesis protein
NHAM_RS17580	COG0803	Belongs to the bacterial solute-binding protein 9 family
NHAM_RS17590	COG1121	(ABC) transporter
NHAM_RS17600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHAM_RS17605	COG2201	protein-glutamate methylesterase activity
NHAM_RS17610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHAM_RS17625	COG1937	Protein conserved in bacteria
NHAM_RS17630	COG1278	Cold shock
NHAM_RS17645	COG0514	ATP-dependent DNA helicase (RecQ)
NHAM_RS17675	COG2181	nitrate reductase activity
NHAM_RS17685	COG1140	nitrate reductase beta subunit
NHAM_RS17695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHAM_RS17710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS17730	COG3346	SURF1 family
NHAM_RS17745	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NHAM_RS17755	COG0109	protoheme IX farnesyltransferase activity
NHAM_RS17760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS17765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHAM_RS17790	COG0523	cobalamin synthesis protein
NHAM_RS17830	COG3474	cytochrome
NHAM_RS17845	COG0165	Argininosuccinate lyase
NHAM_RS17850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHAM_RS17855	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHAM_RS17860	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NHAM_RS17865	COG2086	electron transfer activity
NHAM_RS17890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NHAM_RS17900	COG0784	Response regulator, receiver
NHAM_RS17900	COG4191	Histidine kinase
NHAM_RS17910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS17915	COG1959	2 iron, 2 sulfur cluster binding
NHAM_RS17930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NHAM_RS17930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NHAM_RS17945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NHAM_RS17965	COG4772	TonB-dependent receptor
NHAM_RS17975	COG0604	alcohol dehydrogenase
NHAM_RS17990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NHAM_RS17990	COG0574	Belongs to the PEP-utilizing enzyme family
NHAM_RS17995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHAM_RS18000	COG0037	tRNA processing
NHAM_RS18010	COG2885	chlorophyll binding
NHAM_RS18020	COG5001	Diguanylate cyclase
NHAM_RS18025	COG0823	Involved in the tonB-independent uptake of proteins
NHAM_RS18065	COG0824	Thioesterase
NHAM_RS18070	COG2255	four-way junction helicase activity
NHAM_RS18075	COG0632	four-way junction helicase activity
NHAM_RS18080	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NHAM_RS18085	COG2239	Acts as a magnesium transporter
NHAM_RS18090	COG0217	transcriptional regulatory protein
NHAM_RS18100	COG1692	metallophosphoesterase
NHAM_RS18105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NHAM_RS18130	COG0126	phosphoglycerate kinase activity
NHAM_RS18135	COG3588	fructose-bisphosphate aldolase
NHAM_RS18150	COG0483	inositol monophosphate 1-phosphatase activity
NHAM_RS18155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS18185	COG1132	(ABC) transporter
NHAM_RS18190	COG0254	rRNA binding
NHAM_RS18205	COG0604	alcohol dehydrogenase
NHAM_RS18205	COG1028	Short-chain dehydrogenase reductase Sdr
NHAM_RS18205	COG3321	synthase
NHAM_RS18210	COG4251	negative regulation of phosphorylation
NHAM_RS18210	COG2203	Gaf domain
NHAM_RS18210	COG3706	GGDEF domain
NHAM_RS18210	COG5001	Diguanylate cyclase
NHAM_RS18215	COG1678	Uncharacterized ACR, COG1678
NHAM_RS18235	COG1028	Short-chain dehydrogenase reductase Sdr
NHAM_RS18250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NHAM_RS18255	COG4208	sulfate ABC transporter
NHAM_RS18260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NHAM_RS18265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NHAM_RS18270	COG0175	sulfate reduction
NHAM_RS18275	COG1648	precorrin-2 dehydrogenase activity
NHAM_RS18275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NHAM_RS18280	COG0175	sulfate reduction
NHAM_RS18290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NHAM_RS18310	COG0784	Response regulator, receiver
NHAM_RS18335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHAM_RS18340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NHAM_RS18355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NHAM_RS18360	COG0228	four-way junction DNA binding
NHAM_RS18365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NHAM_RS18370	COG0336	Belongs to the RNA methyltransferase TrmD family
NHAM_RS18375	COG0335	large ribosomal subunit rRNA binding
NHAM_RS18380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NHAM_RS18415	COG0066	3-isopropylmalate dehydratase activity
NHAM_RS18420	COG0288	reversible hydration of carbon dioxide
NHAM_RS18425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHAM_RS18435	COG0473	3-isopropylmalate dehydrogenase activity
NHAM_RS18440	COG0477	Major facilitator Superfamily
NHAM_RS18445	COG2032	superoxide dismutase activity
NHAM_RS18450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NHAM_RS18455	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
NHAM_RS18460	COG0318	PFAM AMP-dependent synthetase and ligase
NHAM_RS18470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS18475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHAM_RS18480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NHAM_RS18525	COG2271	Major facilitator Superfamily
NHAM_RS18530	COG1877	trehalose-phosphatase activity
NHAM_RS18535	COG3387	PFAM Glycoside hydrolase 15-related
NHAM_RS18540	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NHAM_RS18585	COG0137	argininosuccinate synthase activity
NHAM_RS18590	COG0671	phosphoesterase, PA-phosphatase related
NHAM_RS18600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NHAM_RS18620	COG2154	pterin-4-alpha-carbinolamine dehydratase
NHAM_RS18625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NHAM_RS18630	COG3189	MarR family transcriptional regulator
NHAM_RS18635	COG0326	Molecular chaperone. Has ATPase activity
NHAM_RS18655	COG1477	protein flavinylation
NHAM_RS18660	COG3128	pkhd-type hydroxylase
NHAM_RS18665	COG4774	siderophore transport
NHAM_RS18675	COG0848	biopolymer transport protein
NHAM_RS18685	COG0653	protein targeting
NHAM_RS18690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS18695	COG0583	DNA-binding transcription factor activity
NHAM_RS18730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHAM_RS18780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NHAM_RS18785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NHAM_RS18790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NHAM_RS18790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHAM_RS18800	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NHAM_RS18830	COG0737	Belongs to the 5'-nucleotidase family
NHAM_RS18840	COG3258	Cytochrome c
NHAM_RS18865	COG2514	catechol 2,3-dioxygenase activity
NHAM_RS18870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHAM_RS18880	COG1595	DNA-templated transcription, initiation
NHAM_RS18890	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS18900	COG3437	response regulator, receiver
NHAM_RS18900	COG0784	Response regulator, receiver
NHAM_RS18905	COG4191	Histidine kinase
NHAM_RS18905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHAM_RS18910	COG1653	transport
NHAM_RS18915	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
NHAM_RS18930	COG0697	spore germination
NHAM_RS18935	COG2223	nitrite transmembrane transporter activity
NHAM_RS18945	COG0242	peptide deformylase activity
NHAM_RS18950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NHAM_RS18955	COG0101	tRNA pseudouridine synthase activity
NHAM_RS18965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHAM_RS18970	COG2171	N-acyltransferase activity
NHAM_RS18980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NHAM_RS18990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NHAM_RS18995	COG0706	membrane insertase activity
NHAM_RS19005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NHAM_RS19020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NHAM_RS19040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHAM_RS19060	COG4771	TonB-dependent receptor
NHAM_RS19105	COG0671	phosphoesterase, PA-phosphatase related
NHAM_RS19125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NHAM_RS19130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHAM_RS19150	COG0318	PFAM AMP-dependent synthetase and ligase
NHAM_RS19155	COG1686	Belongs to the peptidase S11 family
NHAM_RS19160	COG1132	(ABC) transporter
NHAM_RS19175	COG1238	metal cluster binding
NHAM_RS19195	COG0328	RNA-DNA hybrid ribonuclease activity
NHAM_RS19200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NHAM_RS19205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NHAM_RS19230	COG4451	ribulose bisphosphate carboxylase, small
NHAM_RS19235	COG1850	ribulose-bisphosphate carboxylase activity
NHAM_RS19250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NHAM_RS19330	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS19385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHAM_RS19395	COG0784	Response regulator, receiver
NHAM_RS19395	COG2205	protein histidine kinase activity
NHAM_RS19430	COG5642	Protein of unknown function (DUF2384)
NHAM_RS19450	COG3685	Protein conserved in bacteria
NHAM_RS19455	COG4372	Transposase
NHAM_RS19490	COG2199	diguanylate cyclase activity
NHAM_RS19545	COG4178	(ABC) transporter
NHAM_RS19555	COG3415	Transposase
NHAM_RS19555	COG2801	Transposase and inactivated derivatives
NHAM_RS19595	COG0753	catalase activity
NHAM_RS19600	COG0753	catalase activity
NHAM_RS19620	COG3415	Transposase
NHAM_RS19620	COG2801	Transposase and inactivated derivatives
NHAM_RS19720	COG1002	Type II restriction enzyme, methylase subunits
NHAM_RS19730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS19755	COG1793	dna ligase
NHAM_RS19755	COG3285	dna ligase
NHAM_RS19795	COG1192	Involved in chromosome partitioning
NHAM_RS19825	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS19855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NHAM_RS19895	COG2261	transglycosylase associated protein
NHAM_RS19900	COG0628	permease
NHAM_RS19915	COG3344	reverse transcriptase
NHAM_RS19935	COG3039	Transposase
NHAM_RS19955	COG3038	cytochrome b561
NHAM_RS20000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHAM_RS20015	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NHAM_RS20020	COG1793	dna ligase
NHAM_RS20025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NHAM_RS20035	COG0587	DNA-directed DNA polymerase activity
NHAM_RS20070	COG0546	phosphoglycolate phosphatase activity
NHAM_RS20075	COG0723	plastoquinol--plastocyanin reductase activity
NHAM_RS20075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHAM_RS20080	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NHAM_RS20085	COG0071	Belongs to the small heat shock protein (HSP20) family
NHAM_RS20195	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS20210	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS20265	COG1525	nuclease
NHAM_RS20315	COG0517	IMP dehydrogenase activity
NHAM_RS20330	COG2860	membrane
NHAM_RS20355	COG0586	Pfam SNARE associated Golgi protein
NHAM_RS20365	COG3384	dioxygenase
NHAM_RS20400	COG1959	2 iron, 2 sulfur cluster binding
NHAM_RS20400	COG1295	ribonuclease BN
NHAM_RS20410	COG4372	Transposase
NHAM_RS20425	COG3237	CsbD-like
NHAM_RS20435	COG4178	(ABC) transporter
NHAM_RS20455	COG3547	Transposase (IS116 IS110 IS902 family)
NHAM_RS20535	COG0009	L-threonylcarbamoyladenylate synthase
NHAM_RS20540	COG0277	FAD linked oxidase domain protein
NHAM_RS20545	COG2135	peptidase activity
NHAM_RS20580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NHAM_RS20585	COG0354	folic acid binding
NHAM_RS20590	COG0519	Catalyzes the synthesis of GMP from XMP
NHAM_RS20595	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
NHAM_RS20605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NHAM_RS20645	COG4227	nucleotidyltransferase activity
NHAM_RS20710	COG0268	Binds directly to 16S ribosomal RNA
NHAM_RS21000	COG2205	protein histidine kinase activity
NHAM_RS21085	COG0285	dihydrofolate synthase activity
NHAM_RS21095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NHAM_RS21270	COG0625	glutathione transferase activity
NHAM_RS21320	COG0445	tRNA wobble uridine modification
NHAM_RS21375	COG3328	transposase activity
NHAM_RS21835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHAM_RS21835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHAM_RS22190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHAM_RS22330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NHAM_RS22335	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NHAM_RS22390	COG1185	polyribonucleotide nucleotidyltransferase activity
NHAM_RS22630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NHAM_RS22735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHAM_RS22830	COG1331	Highly conserved protein containing a thioredoxin domain
NHAM_RS23355	COG1185	polyribonucleotide nucleotidyltransferase activity
NHAM_RS23465	COG0802	atpase or kinase
NHAM_RS23530	COG0159	tryptophan synthase activity
NHAM_RS23535	COG0133	tryptophan synthase activity
NHAM_RS23725	COG0495	leucyl-tRNA aminoacylation
NHAM_RS23785	COG0445	tRNA wobble uridine modification
NHAM_RS23815	COG4712	double-strand break repair protein
NHAM_RS23900	COG2197	response regulator
NHAM_RS23925	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NHAM_RS23940	COG2089	acid synthase
NHAM_RS23945	COG1083	cytidylyl-transferase
NHAM_RS23950	COG3920	Histidine kinase
NHAM_RS23995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NHAM_RS24095	COG4372	Transposase
NHAM_RS24145	COG1047	Peptidyl-prolyl cis-trans
NHAM_RS24150	COG3293	Transposase
NHAM_RS24220	COG0815	Transfers the fatty acyl group on membrane lipoproteins