locus-tag	class	description
E3U44_RS00040	COG1404	Belongs to the peptidase S8 family
E3U44_RS00050	COG1525	nuclease
E3U44_RS00100	COG4983	Phage plasmid primase, P4 family domain protein
E3U44_RS00115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3U44_RS00120	COG4172	Belongs to the ABC transporter superfamily
E3U44_RS00130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U44_RS00135	COG0601	transmembrane transport
E3U44_RS00150	COG2204	response regulator
E3U44_RS00155	COG1538	Outer membrane efflux protein
E3U44_RS00190	COG2204	response regulator
E3U44_RS00220	COG2815	serine threonine protein kinase
E3U44_RS00220	COG0515	serine threonine protein kinase
E3U44_RS00265	COG0488	(ABC) transporter
E3U44_RS00300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U44_RS00375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U44_RS00405	COG1394	ATPase activity, coupled to movement of substances
E3U44_RS00410	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E3U44_RS00415	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E3U44_RS00420	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
E3U44_RS00475	COG2226	methyltransferase
E3U44_RS00480	COG2267	carboxylic ester hydrolase activity
E3U44_RS00485	COG0156	8-amino-7-oxononanoate synthase activity
E3U44_RS00490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3U44_RS00495	COG1040	competence protein
E3U44_RS00505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E3U44_RS00510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3U44_RS00520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3U44_RS00525	COG1758	RNA polymerase activity
E3U44_RS00530	COG0194	GDP metabolic process
E3U44_RS00565	COG1561	YicC-like family, N-terminal region
E3U44_RS00570	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E3U44_RS00585	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
E3U44_RS00590	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E3U44_RS00605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3U44_RS00610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3U44_RS00615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3U44_RS00620	COG4566	intracellular signal transduction
E3U44_RS00625	COG4191	Histidine kinase
E3U44_RS00635	COG0471	metal ion transport
E3U44_RS00640	COG2957	Belongs to the agmatine deiminase family
E3U44_RS00645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U44_RS00650	COG4251	negative regulation of phosphorylation
E3U44_RS00660	COG4191	Histidine kinase
E3U44_RS00675	COG0436	Aminotransferase
E3U44_RS00685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3U44_RS00690	COG0571	ribonuclease III activity
E3U44_RS00700	COG0681	Belongs to the peptidase S26 family
E3U44_RS00705	COG0481	GTPase activity
E3U44_RS00710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U44_RS00720	COG3026	antisigma factor binding
E3U44_RS00745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E3U44_RS00755	COG1053	succinate dehydrogenase
E3U44_RS00760	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E3U44_RS00775	COG0776	regulation of translation
E3U44_RS00780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U44_RS00785	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS00790	COG0367	asparagine synthase
E3U44_RS00795	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS00810	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E3U44_RS00815	COG0529	Catalyzes the synthesis of activated sulfate
E3U44_RS00825	COG0250	Participates in transcription elongation, termination and antitermination
E3U44_RS00835	COG0822	iron-sulfur transferase activity
E3U44_RS00840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U44_RS00845	COG0719	Fe-S assembly protein
E3U44_RS00855	COG0719	Fe-S assembly protein
E3U44_RS00865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3U44_RS00870	COG0546	phosphoglycolate phosphatase activity
E3U44_RS00880	COG0512	Glutamine amidotransferase of anthranilate synthase
E3U44_RS00885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3U44_RS00890	COG0134	indole-3-glycerol-phosphate synthase activity
E3U44_RS00925	COG0560	Phosphoserine phosphatase
E3U44_RS00930	COG0516	GMP reductase activity
E3U44_RS00945	COG2719	SpoVR family
E3U44_RS00950	COG2718	Belongs to the UPF0229 family
E3U44_RS00955	COG2766	serine protein kinase
E3U44_RS00960	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS00965	COG0730	response to heat
E3U44_RS00970	COG0494	nUDIX hydrolase
E3U44_RS00975	COG3174	membrane
E3U44_RS00985	COG1573	uracil-dna glycosylase
E3U44_RS00990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3U44_RS00995	COG1183	phosphatidylcholine synthase activity
E3U44_RS01000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3U44_RS01010	COG0028	Belongs to the TPP enzyme family
E3U44_RS01015	COG0418	dihydroorotase activity
E3U44_RS01020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3U44_RS01025	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E3U44_RS01030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3U44_RS01040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3U44_RS01050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U44_RS01090	COG1238	metal cluster binding
E3U44_RS01105	COG3609	addiction module antidote protein, CC2985 family
E3U44_RS01125	COG0367	asparagine synthase
E3U44_RS01150	COG0463	Glycosyl transferase, family 2
E3U44_RS01170	COG2361	Protein of unknown function DUF86
E3U44_RS01190	COG2026	Addiction module toxin, RelE StbE family
E3U44_RS01230	COG1217	gtp-binding protein TYPA
E3U44_RS01245	COG1388	LysM domain
E3U44_RS01245	COG1376	ErfK ybiS ycfS ynhG family protein
E3U44_RS01260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3U44_RS01265	COG0045	succinate-CoA ligase (ADP-forming) activity
E3U44_RS01275	COG1490	D-aminoacyl-tRNA deacylase activity
E3U44_RS01285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E3U44_RS01295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3U44_RS01300	COG1509	lysine 2,3-aminomutase activity
E3U44_RS01310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3U44_RS01315	COG0321	lipoyl(octanoyl) transferase activity
E3U44_RS01320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U44_RS01325	COG1686	Belongs to the peptidase S11 family
E3U44_RS01335	COG2951	lytic endotransglycosylase activity
E3U44_RS01340	COG0772	Belongs to the SEDS family
E3U44_RS01345	COG0768	penicillin binding
E3U44_RS01350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3U44_RS01355	COG1792	Involved in formation and maintenance of cell shape
E3U44_RS01360	COG1077	Cell shape determining protein MreB Mrl
E3U44_RS01365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3U44_RS01370	COG0154	amidase activity
E3U44_RS01375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3U44_RS01390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3U44_RS01395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3U44_RS01410	COG1131	(ABC) transporter
E3U44_RS01430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3U44_RS01445	COG0174	glutamine synthetase
E3U44_RS01450	COG0425	Belongs to the sulfur carrier protein TusA family
E3U44_RS01455	COG0482	sulfurtransferase activity
E3U44_RS01460	COG0312	modulator of DNA gyrase
E3U44_RS01485	COG0424	maF-like protein
E3U44_RS01490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E3U44_RS01500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3U44_RS01505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3U44_RS01510	COG1466	dna polymerase III delta subunit
E3U44_RS01515	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E3U44_RS01520	COG0495	leucyl-tRNA aminoacylation
E3U44_RS01525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3U44_RS01530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E3U44_RS01540	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3U44_RS01545	COG1136	(ABC) transporter
E3U44_RS01555	COG0658	competence protein
E3U44_RS01555	COG2333	competence protein COMEC
E3U44_RS01560	COG0811	peptide transport
E3U44_RS01565	COG0848	biopolymer transport protein
E3U44_RS01570	COG1132	(ABC) transporter
E3U44_RS01575	COG1663	tetraacyldisaccharide 4'-kinase activity
E3U44_RS01580	COG2835	tetraacyldisaccharide 4'-kinase activity
E3U44_RS01585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3U44_RS01590	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3U44_RS01595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3U44_RS01600	COG5001	Diguanylate cyclase
E3U44_RS01600	COG5002	protein histidine kinase activity
E3U44_RS01605	COG0314	molybdopterin synthase activity
E3U44_RS01610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3U44_RS01615	COG0315	cyclic pyranopterin monophosphate synthase activity
E3U44_RS01675	COG5433	transposase activity
E3U44_RS01700	COG1598	PFAM Uncharacterised protein family UPF0150
E3U44_RS01730	COG3335	DDE superfamily endonuclease
E3U44_RS01765	COG0582	viral genome integration into host DNA
E3U44_RS01835	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS01840	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS01855	COG4566	intracellular signal transduction
E3U44_RS01890	COG0582	viral genome integration into host DNA
E3U44_RS01940	COG0564	pseudouridine synthase activity
E3U44_RS01950	COG0205	6-phosphofructokinase activity
E3U44_RS01955	COG0563	adenylate kinase activity
E3U44_RS01960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3U44_RS01970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3U44_RS01975	COG0653	protein targeting
E3U44_RS01980	COG0739	heme binding
E3U44_RS01990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E3U44_RS02005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3U44_RS02010	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3U44_RS02015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3U44_RS02020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3U44_RS02025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3U44_RS02030	COG0772	Belongs to the SEDS family
E3U44_RS02035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3U44_RS02040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U44_RS02045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3U44_RS02050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3U44_RS02060	COG3116	cell division
E3U44_RS02065	COG0275	rRNA processing
E3U44_RS02070	COG2001	Belongs to the MraZ family
E3U44_RS02095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3U44_RS02100	COG3107	peptidoglycan biosynthetic process
E3U44_RS02105	COG0792	nuclease activity
E3U44_RS02110	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3U44_RS02115	COG2823	Periplasmic or secreted lipoprotein
E3U44_RS02120	COG0277	FAD linked oxidase domain protein
E3U44_RS02135	COG1127	ABC transporter
E3U44_RS02145	COG3218	ABC-type transport auxiliary lipoprotein component
E3U44_RS02150	COG0647	UMP catabolic process
E3U44_RS02180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3U44_RS02190	COG0708	Exodeoxyribonuclease III
E3U44_RS02195	COG0339	signal peptide processing
E3U44_RS02200	COG5002	protein histidine kinase activity
E3U44_RS02225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3U44_RS02270	COG0742	ribosomal rna small subunit methyltransferase
E3U44_RS02280	COG1324	tolerance protein
E3U44_RS02285	COG4232	protein-disulfide reductase activity
E3U44_RS02290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U44_RS02295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3U44_RS02300	COG0511	ligase activity, forming carbon-carbon bonds
E3U44_RS02305	COG0439	Biotin carboxylase
E3U44_RS02310	COG2264	protein methyltransferase activity
E3U44_RS02315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E3U44_RS02320	COG0138	bifunctional purine biosynthesis protein purh
E3U44_RS02330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3U44_RS02345	COG0316	Belongs to the HesB IscA family
E3U44_RS02355	COG1562	ergosterol biosynthetic process
E3U44_RS02365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3U44_RS02370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3U44_RS02375	COG0180	Tryptophanyl-tRNA synthetase
E3U44_RS02380	COG1994	Peptidase M50
E3U44_RS02385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3U44_RS02400	COG2076	Multidrug Resistance protein
E3U44_RS02410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3U44_RS02420	COG2936	dipeptidyl-peptidase activity
E3U44_RS02425	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3U44_RS02440	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3U44_RS02455	COG5001	Diguanylate cyclase
E3U44_RS02455	COG5002	protein histidine kinase activity
E3U44_RS02465	COG0142	geranyltranstransferase activity
E3U44_RS02480	COG0861	Integral membrane protein TerC family
E3U44_RS02485	COG1511	domain protein
E3U44_RS02485	COG3264	Mechanosensitive ion channel
E3U44_RS02500	COG1355	regulation of microtubule-based process
E3U44_RS02525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3U44_RS02545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3U44_RS02550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3U44_RS02560	COG1987	bacterial-type flagellum assembly
E3U44_RS02595	COG0463	Glycosyl transferase, family 2
E3U44_RS02640	COG0463	Glycosyl transferase, family 2
E3U44_RS02675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U44_RS02700	COG1450	Type ii and iii secretion system protein
E3U44_RS02720	COG3156	type II secretion system protein K
E3U44_RS02770	COG1216	Glycosyl transferase, family 2
E3U44_RS02815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U44_RS02830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3U44_RS02835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3U44_RS02840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3U44_RS02845	COG1331	Highly conserved protein containing a thioredoxin domain
E3U44_RS02860	COG1007	ATP synthesis coupled electron transport
E3U44_RS02875	COG0713	ATP synthesis coupled electron transport
E3U44_RS02885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS02890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E3U44_RS02900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3U44_RS02905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E3U44_RS02910	COG0649	NAD binding
E3U44_RS02915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS02920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS02925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS02940	COG0149	triose-phosphate isomerase activity
E3U44_RS02945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3U44_RS02950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3U44_RS02960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E3U44_RS02965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3U44_RS02970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3U44_RS02975	COG0505	Belongs to the CarA family
E3U44_RS02985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3U44_RS03010	COG0006	proline dipeptidase activity
E3U44_RS03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U44_RS03020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U44_RS03025	COG0513	Belongs to the DEAD box helicase family
E3U44_RS03035	COG4520	surface antigen
E3U44_RS03045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3U44_RS03050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E3U44_RS03055	COG0330	HflC and HflK could
E3U44_RS03060	COG0330	HflC and HflK could
E3U44_RS03065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3U44_RS03070	COG1923	regulation of RNA biosynthetic process
E3U44_RS03075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3U44_RS03080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3U44_RS03100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3U44_RS03105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3U44_RS03110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E3U44_RS03115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3U44_RS03120	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E3U44_RS03125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3U44_RS03130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3U44_RS03145	COG4636	protein conserved in cyanobacteria
E3U44_RS03155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3U44_RS03155	COG0519	Catalyzes the synthesis of GMP from XMP
E3U44_RS03165	COG1570	exodeoxyribonuclease VII activity
E3U44_RS03180	COG0848	biopolymer transport protein
E3U44_RS03185	COG0811	peptide transport
E3U44_RS03190	COG0811	peptide transport
E3U44_RS03210	COG1773	rubredoxin
E3U44_RS03215	COG0352	thiamine-phosphate diphosphorylase activity
E3U44_RS03225	COG0668	transmembrane transport
E3U44_RS03230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3U44_RS03240	COG0210	DNA helicase
E3U44_RS03245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E3U44_RS03265	COG4274	PFAM GYD family protein
E3U44_RS03280	COG0189	ligase activity
E3U44_RS03280	COG4067	protein conserved in archaea
E3U44_RS03305	COG0784	Response regulator, receiver
E3U44_RS03305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U44_RS03305	COG2205	protein histidine kinase activity
E3U44_RS03305	COG2198	Histidine kinase
E3U44_RS03330	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS03360	COG1872	DUF167
E3U44_RS03365	COG2223	nitrite transmembrane transporter activity
E3U44_RS03370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3U44_RS03385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3U44_RS03395	COG0756	dUTP diphosphatase activity
E3U44_RS03405	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E3U44_RS03410	COG1073	alpha beta
E3U44_RS03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3U44_RS03460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3U44_RS03475	COG2922	Belongs to the Smg family
E3U44_RS03480	COG0758	DNA mediated transformation
E3U44_RS03485	COG1652	LysM domain
E3U44_RS03490	COG0242	peptide deformylase activity
E3U44_RS03495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3U44_RS03510	COG5000	phosphorelay sensor kinase activity
E3U44_RS03515	COG2204	response regulator
E3U44_RS03520	COG0569	domain protein
E3U44_RS03530	COG2814	Major facilitator Superfamily
E3U44_RS03535	COG0629	single-stranded DNA binding
E3U44_RS03550	COG1408	metallophosphoesterase
E3U44_RS03560	COG3237	CsbD-like
E3U44_RS03565	COG4191	Histidine kinase
E3U44_RS03610	COG1253	flavin adenine dinucleotide binding
E3U44_RS03615	COG1253	flavin adenine dinucleotide binding
E3U44_RS03630	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U44_RS03635	COG0567	Dehydrogenase, E1 component
E3U44_RS03650	COG0297	glycogen (starch) synthase activity
E3U44_RS03660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3U44_RS03665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3U44_RS03670	COG1309	transcriptional regulator
E3U44_RS03690	COG0537	adenosine 5'-monophosphoramidase activity
E3U44_RS03710	COG0142	geranyltranstransferase activity
E3U44_RS03715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3U44_RS03720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3U44_RS03725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3U44_RS03730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3U44_RS03750	COG0268	Binds directly to 16S ribosomal RNA
E3U44_RS03755	COG0728	peptidoglycan biosynthetic process
E3U44_RS03760	COG0109	protoheme IX farnesyltransferase activity
E3U44_RS03765	COG1612	heme a metabolic process
E3U44_RS03790	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E3U44_RS03795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS03800	COG1565	acr, cog1565
E3U44_RS03800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U44_RS03825	COG0131	Imidazoleglycerol-phosphate dehydratase
E3U44_RS03830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3U44_RS03835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3U44_RS03840	COG0107	imidazoleglycerol-phosphate synthase activity
E3U44_RS03845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3U44_RS03850	COG0140	phosphoribosyl-ATP diphosphatase activity
E3U44_RS03860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U44_RS03865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U44_RS03890	COG0531	amino acid
E3U44_RS03895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3U44_RS03895	COG4651	solute:proton antiporter activity
E3U44_RS03935	COG0358	DNA primase activity
E3U44_RS03945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3U44_RS03950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3U44_RS03955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E3U44_RS03960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3U44_RS03980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3U44_RS03985	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E3U44_RS03995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U44_RS04000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E3U44_RS04005	COG0793	Belongs to the peptidase S41A family
E3U44_RS04010	COG0693	protein deglycase activity
E3U44_RS04015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3U44_RS04020	COG0018	arginyl-trna synthetase
E3U44_RS04030	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3U44_RS04040	COG1229	Formylmethanofuran dehydrogenase subunit A
E3U44_RS04045	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
E3U44_RS04055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E3U44_RS04070	COG1891	lyase activity
E3U44_RS04090	COG0187	DNA topoisomerase II activity
E3U44_RS04095	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3U44_RS04100	COG0592	DNA-directed DNA polymerase activity
E3U44_RS04105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3U44_RS04110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3U44_RS04115	COG0594	ribonuclease P activity
E3U44_RS04120	COG0706	membrane insertase activity
E3U44_RS04125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3U44_RS04130	COG0445	tRNA wobble uridine modification
E3U44_RS04135	COG0357	Ribosomal RNA small subunit methyltransferase G
E3U44_RS04140	COG1192	Involved in chromosome partitioning
E3U44_RS04145	COG1475	DNA binding
E3U44_RS04155	COG0356	it plays a direct role in the translocation of protons across the membrane
E3U44_RS04160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3U44_RS04165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3U44_RS04170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3U44_RS04175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3U44_RS04180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3U44_RS04185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3U44_RS04190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3U44_RS04195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3U44_RS04210	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS04215	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS04220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U44_RS04225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3U44_RS04230	COG0165	Argininosuccinate lyase
E3U44_RS04255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E3U44_RS04260	COG2894	cell division
E3U44_RS04265	COG0850	regulation of cytokinetic process
E3U44_RS04270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3U44_RS04275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3U44_RS04285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E3U44_RS04290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3U44_RS04300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3U44_RS04305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3U44_RS04310	COG0193	aminoacyl-tRNA hydrolase activity
E3U44_RS04315	COG0012	GTP binding
E3U44_RS04325	COG0582	viral genome integration into host DNA
E3U44_RS04330	COG0443	Heat shock 70 kDa protein
E3U44_RS04405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3U44_RS04530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3U44_RS04535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3U44_RS04540	COG2003	Belongs to the UPF0758 family
E3U44_RS04550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3U44_RS04555	COG1702	phosphate starvation-inducible protein PhoH
E3U44_RS04560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3U44_RS04565	COG4535	Mg2 and Co2 transporter CorC
E3U44_RS04570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E3U44_RS04575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3U44_RS04580	COG0254	rRNA binding
E3U44_RS04585	COG0281	malic enzyme
E3U44_RS04625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3U44_RS04630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3U44_RS04655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3U44_RS04660	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
E3U44_RS04670	COG0189	ligase activity
E3U44_RS04675	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E3U44_RS04695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3U44_RS04700	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E3U44_RS04705	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E3U44_RS04720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3U44_RS04735	COG2969	positive regulation of protein catabolic process
E3U44_RS04740	COG0625	glutathione transferase activity
E3U44_RS04745	COG2857	Cytochrome c1
E3U44_RS04750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3U44_RS04755	COG0723	plastoquinol--plastocyanin reductase activity
E3U44_RS04770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3U44_RS04775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3U44_RS04790	COG0352	thiamine-phosphate diphosphorylase activity
E3U44_RS04795	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E3U44_RS04800	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E3U44_RS04805	COG0237	dephospho-CoA kinase activity
E3U44_RS04810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3U44_RS04830	COG0019	diaminopimelate decarboxylase activity
E3U44_RS04835	COG4106	trans-aconitate 2-methyltransferase activity
E3U44_RS04840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3U44_RS04850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E3U44_RS04865	COG0811	peptide transport
E3U44_RS04870	COG0811	peptide transport
E3U44_RS04875	COG0848	biopolymer transport protein
E3U44_RS04930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3U44_RS04935	COG0366	Alpha amylase catalytic
E3U44_RS04945	COG1278	Cold shock
E3U44_RS04990	COG2801	Transposase and inactivated derivatives
E3U44_RS04995	COG2801	Transposase and inactivated derivatives
E3U44_RS05040	COG3335	DDE superfamily endonuclease
E3U44_RS05045	COG2094	Belongs to the DNA glycosylase MPG family
E3U44_RS05050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3U44_RS05060	COG4636	protein conserved in cyanobacteria
E3U44_RS05110	COG0784	Response regulator, receiver
E3U44_RS05110	COG2205	protein histidine kinase activity
E3U44_RS05140	COG3153	acetyltransferase
E3U44_RS05140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U44_RS05155	COG4172	Belongs to the ABC transporter superfamily
E3U44_RS05160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U44_RS05165	COG0601	transmembrane transport
E3U44_RS05175	COG0724	RNA recognition motif
E3U44_RS05230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3U44_RS05235	COG0459	protein refolding
E3U44_RS05250	COG2217	Heavy metal translocating P-type atpase
E3U44_RS05255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3U44_RS05265	COG0217	transcriptional regulatory protein
E3U44_RS05270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3U44_RS05275	COG0632	four-way junction helicase activity
E3U44_RS05280	COG2255	four-way junction helicase activity
E3U44_RS05285	COG0824	Thioesterase
E3U44_RS05305	COG0823	Involved in the tonB-independent uptake of proteins
E3U44_RS05310	COG2885	chlorophyll binding
E3U44_RS05320	COG0602	queuosine metabolic process
E3U44_RS05325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E3U44_RS05435	COG1024	Enoyl-CoA hydratase
E3U44_RS05440	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS05510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U44_RS05520	COG3387	PFAM Glycoside hydrolase 15-related
E3U44_RS05550	COG0543	2 iron, 2 sulfur cluster binding
E3U44_RS05560	COG0540	Belongs to the ATCase OTCase family
E3U44_RS05565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E3U44_RS05570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3U44_RS05575	COG1678	Uncharacterized ACR, COG1678
E3U44_RS05585	COG0189	ligase activity
E3U44_RS05590	COG0729	surface antigen
E3U44_RS05595	COG2911	Protein conserved in bacteria
E3U44_RS05605	COG0751	glycine-tRNA ligase activity
E3U44_RS05610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E3U44_RS05635	COG0617	tRNA 3'-terminal CCA addition
E3U44_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
E3U44_RS05680	COG3093	addiction module antidote protein HigA
E3U44_RS05745	COG0312	modulator of DNA gyrase
E3U44_RS05805	COG3976	FMN-binding domain protein
E3U44_RS05805	COG1053	succinate dehydrogenase
E3U44_RS05820	COG0723	plastoquinol--plastocyanin reductase activity
E3U44_RS05820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U44_RS05840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E3U44_RS05855	COG0366	Alpha amylase catalytic
E3U44_RS05860	COG0501	Belongs to the peptidase M48B family
E3U44_RS05885	COG2323	membrane
E3U44_RS05890	COG0531	amino acid
E3U44_RS05895	COG2890	protein-(glutamine-N5) methyltransferase activity
E3U44_RS05900	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3U44_RS05915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3U44_RS05945	COG0640	Transcriptional regulator
E3U44_RS05955	COG1272	protein, Hemolysin III
E3U44_RS05960	COG2081	HI0933 family
E3U44_RS05975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3U44_RS06020	COG2132	Multicopper oxidase
E3U44_RS06040	COG1598	PFAM Uncharacterised protein family UPF0150
E3U44_RS06045	COG2814	Major facilitator Superfamily
E3U44_RS06050	COG0039	L-malate dehydrogenase activity
E3U44_RS06065	COG2239	Acts as a magnesium transporter
E3U44_RS06070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3U44_RS06075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U44_RS06085	COG1660	Displays ATPase and GTPase activities
E3U44_RS06090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E3U44_RS06105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3U44_RS06110	COG1137	ATPase activity
E3U44_RS06125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E3U44_RS06135	COG2853	Lipoprotein
E3U44_RS06140	COG1127	ABC transporter
E3U44_RS06145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3U44_RS06150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E3U44_RS06175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3U44_RS06180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3U44_RS06185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3U44_RS06190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3U44_RS06200	COG2116	formate transmembrane transporter activity
E3U44_RS06210	COG0318	PFAM AMP-dependent synthetase and ligase
E3U44_RS06215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3U44_RS06240	COG1388	LysM domain
E3U44_RS06240	COG3942	CHAP domain
E3U44_RS06250	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U44_RS06265	COG0076	glutamate decarboxylase activity
E3U44_RS06270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3U44_RS06275	COG1260	myo-inositol-1-phosphate synthase
E3U44_RS06285	COG5001	Diguanylate cyclase
E3U44_RS06290	COG2902	Dehydrogenase
E3U44_RS06305	COG3854	ATPases associated with a variety of cellular activities
E3U44_RS06320	COG0277	FAD linked oxidase domain protein
E3U44_RS06330	COG1730	sister chromatid segregation
E3U44_RS06350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS06365	COG1959	2 iron, 2 sulfur cluster binding
E3U44_RS06375	COG0776	regulation of translation
E3U44_RS06400	COG0557	exoribonuclease II activity
E3U44_RS06410	COG0688	phosphatidylethanolamine metabolic process
E3U44_RS06415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3U44_RS06420	COG1459	type II secretion system
E3U44_RS06430	COG4970	Tfp pilus assembly protein FimT
E3U44_RS06435	COG2165	general secretion pathway protein
E3U44_RS06445	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS06455	COG2204	response regulator
E3U44_RS06480	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3U44_RS06485	COG1515	deoxyribonuclease V activity
E3U44_RS06495	COG2801	Transposase and inactivated derivatives
E3U44_RS06500	COG2801	Transposase and inactivated derivatives
E3U44_RS06535	COG3848	Pyruvate phosphate dikinase
E3U44_RS06535	COG0574	Belongs to the PEP-utilizing enzyme family
E3U44_RS06555	COG4191	Histidine kinase
E3U44_RS06560	COG4191	Histidine kinase
E3U44_RS06575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3U44_RS06580	COG0360	Binds together with S18 to 16S ribosomal RNA
E3U44_RS06585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3U44_RS06590	COG0359	binds to the 23S rRNA
E3U44_RS06600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3U44_RS06615	COG1981	membrane
E3U44_RS06620	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U44_RS06625	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E3U44_RS06645	COG0535	radical SAM domain protein
E3U44_RS06660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3U44_RS06675	COG0425	Belongs to the sulfur carrier protein TusA family
E3U44_RS06680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3U44_RS06685	COG1538	Outer membrane efflux protein
E3U44_RS06690	COG1519	Transferase
E3U44_RS06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS06700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E3U44_RS06700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3U44_RS06715	COG0724	RNA recognition motif
E3U44_RS06765	COG1012	belongs to the aldehyde dehydrogenase family
E3U44_RS06770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U44_RS06780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3U44_RS06780	COG0446	pyridine nucleotide-disulphide oxidoreductase
E3U44_RS06790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3U44_RS06835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3U44_RS06840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3U44_RS06845	COG1968	undecaprenyl-diphosphatase activity
E3U44_RS06855	COG0842	Transport permease protein
E3U44_RS06860	COG1131	(ABC) transporter
E3U44_RS06875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E3U44_RS06885	COG3954	Phosphoribulokinase
E3U44_RS06890	COG0009	L-threonylcarbamoyladenylate synthase
E3U44_RS06895	COG0408	coproporphyrinogen oxidase activity
E3U44_RS06900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3U44_RS06905	COG0167	dihydroorotate dehydrogenase activity
E3U44_RS06925	COG0328	RNA-DNA hybrid ribonuclease activity
E3U44_RS06935	COG1420	regulation of RNA biosynthetic process
E3U44_RS06940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3U44_RS06945	COG0443	Heat shock 70 kDa protein
E3U44_RS06950	COG0484	heat shock protein binding
E3U44_RS06955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3U44_RS06960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3U44_RS06965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3U44_RS06970	COG0126	phosphoglycerate kinase activity
E3U44_RS06980	COG0191	fructose-bisphosphate aldolase activity
E3U44_RS06995	COG5001	Diguanylate cyclase
E3U44_RS06995	COG5002	protein histidine kinase activity
E3U44_RS07000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3U44_RS07005	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U44_RS07010	COG0802	atpase or kinase
E3U44_RS07015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3U44_RS07015	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E3U44_RS07040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3U44_RS07045	COG0492	ferredoxin-NADP+ reductase activity
E3U44_RS07050	COG0686	Belongs to the AlaDH PNT family
E3U44_RS07055	COG1674	ftsk spoiiie
E3U44_RS07060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3U44_RS07065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3U44_RS07070	COG1530	ribonuclease E activity
E3U44_RS07075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3U44_RS07085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E3U44_RS07090	COG1611	Belongs to the LOG family
E3U44_RS07105	COG0300	oxidoreductase activity
E3U44_RS07115	COG2205	protein histidine kinase activity
E3U44_RS07125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3U44_RS07130	COG0784	Response regulator, receiver
E3U44_RS07130	COG2205	protein histidine kinase activity
E3U44_RS07140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U44_RS07180	COG3387	PFAM Glycoside hydrolase 15-related
E3U44_RS07185	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS07190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U44_RS07255	COG0582	viral genome integration into host DNA
E3U44_RS07295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3U44_RS07330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E3U44_RS07335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3U44_RS07335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3U44_RS07350	COG1166	arginine decarboxylase activity
E3U44_RS07355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E3U44_RS07380	COG0859	PFAM glycosyl transferase family 9
E3U44_RS07385	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS07390	COG0859	PFAM glycosyl transferase family 9
E3U44_RS07425	COG0671	phosphoesterase, PA-phosphatase related
E3U44_RS07440	COG3431	PFAM Phosphate-starvation-inducible E
E3U44_RS07445	COG0577	efflux transmembrane transporter activity
E3U44_RS07445	COG1136	(ABC) transporter
E3U44_RS07450	COG1136	(ABC) transporter
E3U44_RS07450	COG0577	efflux transmembrane transporter activity
E3U44_RS07455	COG1136	(ABC) transporter
E3U44_RS07470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3U44_RS07480	COG2201	protein-glutamate methylesterase activity
E3U44_RS07485	COG0643	Histidine kinase
E3U44_RS07485	COG0784	Response regulator, receiver
E3U44_RS07485	COG2198	Histidine kinase
E3U44_RS07495	COG0840	transmembrane signaling receptor activity
E3U44_RS07570	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS07580	COG0463	Glycosyl transferase, family 2
E3U44_RS07585	COG0463	Glycosyl transferase, family 2
E3U44_RS07630	COG0463	Glycosyl transferase, family 2
E3U44_RS07665	COG1215	transferase activity, transferring glycosyl groups
E3U44_RS07700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS07705	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS07720	COG0367	asparagine synthase
E3U44_RS07870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3U44_RS07875	COG0494	nUDIX hydrolase
E3U44_RS07880	COG0494	nUDIX hydrolase
E3U44_RS07900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3U44_RS07905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3U44_RS07905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3U44_RS07960	COG2960	long-chain fatty acid transporting porin activity
E3U44_RS07965	COG0606	chelatase, subunit chli
E3U44_RS07970	COG0210	DNA helicase
E3U44_RS07975	COG0129	dihydroxy-acid dehydratase activity
E3U44_RS08000	COG2205	protein histidine kinase activity
E3U44_RS08010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3U44_RS08015	COG2205	protein histidine kinase activity
E3U44_RS08015	COG0784	Response regulator, receiver
E3U44_RS08020	COG2204	response regulator
E3U44_RS08055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3U44_RS08075	COG1819	glycosyl
E3U44_RS08155	COG0367	asparagine synthase
E3U44_RS08160	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS08165	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS08180	COG1216	Glycosyl transferase, family 2
E3U44_RS08185	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS08200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3U44_RS08220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3U44_RS08240	COG1216	Glycosyl transferase, family 2
E3U44_RS08250	COG1216	Glycosyl transferase, family 2
E3U44_RS08255	COG0297	glycogen (starch) synthase activity
E3U44_RS08260	COG1216	Glycosyl transferase, family 2
E3U44_RS08265	COG0463	Glycosyl transferase, family 2
E3U44_RS08275	COG3119	arylsulfatase activity
E3U44_RS08290	COG3551	Protein conserved in bacteria
E3U44_RS08295	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS08360	COG0552	protein localization to endoplasmic reticulum
E3U44_RS08365	COG0612	Peptidase, M16
E3U44_RS08370	COG0612	Peptidase, M16
E3U44_RS08375	COG0742	ribosomal rna small subunit methyltransferase
E3U44_RS08380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3U44_RS08385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E3U44_RS08390	COG0667	Aldo Keto reductase
E3U44_RS08410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E3U44_RS08415	COG0297	glycogen (starch) synthase activity
E3U44_RS08420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3U44_RS08445	COG0367	asparagine synthase
E3U44_RS08455	COG0540	Belongs to the ATCase OTCase family
E3U44_RS08480	COG2205	protein histidine kinase activity
E3U44_RS08490	COG2204	response regulator
E3U44_RS08540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E3U44_RS08620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U44_RS08625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U44_RS08655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3U44_RS08660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3U44_RS08665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3U44_RS08675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E3U44_RS08680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3U44_RS08685	COG0542	response to heat
E3U44_RS08690	COG0735	belongs to the Fur family
E3U44_RS08695	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3U44_RS08700	COG1121	(ABC) transporter
E3U44_RS08705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3U44_RS08715	COG0322	excinuclease ABC activity
E3U44_RS08720	COG0494	nUDIX hydrolase
E3U44_RS08735	COG0745	RESPONSE REGULATOR receiver
E3U44_RS08755	COG0573	inorganic phosphate transmembrane transporter activity
E3U44_RS08760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U44_RS08765	COG0704	Plays a role in the regulation of phosphate uptake
E3U44_RS08790	COG2350	Protein conserved in bacteria
E3U44_RS08795	COG2917	probably involved in intracellular septation
E3U44_RS08800	COG0613	PHP domain protein
E3U44_RS08805	COG0009	L-threonylcarbamoyladenylate synthase
E3U44_RS08815	COG0542	response to heat
E3U44_RS08840	COG0300	oxidoreductase activity
E3U44_RS08845	COG1815	bacterial-type flagellum-dependent cell motility
E3U44_RS08850	COG1558	bacterial-type flagellum-dependent cell motility
E3U44_RS08855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3U44_RS08860	COG1749	Flagellar hook protein flgE
E3U44_RS08865	COG4787	bacterial-type flagellum-dependent cell motility
E3U44_RS08870	COG4786	Flagellar basal body rod
E3U44_RS08875	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E3U44_RS08880	COG1706	bacterial-type flagellum-dependent cell motility
E3U44_RS08885	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3U44_RS08885	COG3951	Flagellar rod assembly protein muramidase FlgJ
E3U44_RS08895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3U44_RS08940	COG1677	Flagellar hook-basal body complex protein FliE
E3U44_RS08955	COG1317	bacterial-type flagellum organization
E3U44_RS08975	COG0284	orotidine-5'-phosphate decarboxylase activity
E3U44_RS09000	COG0343	queuine tRNA-ribosyltransferase activity
E3U44_RS09005	COG1862	Preprotein translocase
E3U44_RS09010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U44_RS09015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U44_RS09020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3U44_RS09030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3U44_RS09040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3U44_RS09060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E3U44_RS09065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E3U44_RS09090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3U44_RS09100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3U44_RS09110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3U44_RS09115	COG0081	regulation of translation
E3U44_RS09120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3U44_RS09125	COG0222	ribosome binding
E3U44_RS09130	COG0085	RNA polymerase activity
E3U44_RS09135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3U44_RS09140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3U44_RS09145	COG0049	tRNA binding
E3U44_RS09150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3U44_RS09155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3U44_RS09160	COG0051	transcription antitermination factor activity, RNA binding
E3U44_RS09165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3U44_RS09170	COG0088	Forms part of the polypeptide exit tunnel
E3U44_RS09175	COG0089	rRNA binding
E3U44_RS09180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3U44_RS09185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3U44_RS09190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3U44_RS09195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3U44_RS09200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3U44_RS09205	COG0255	Belongs to the universal ribosomal protein uL29 family
E3U44_RS09210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3U44_RS09215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3U44_RS09220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3U44_RS09225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3U44_RS09230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3U44_RS09235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3U44_RS09240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3U44_RS09245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3U44_RS09250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3U44_RS09255	COG1841	ribosomal large subunit assembly
E3U44_RS09260	COG0200	Binds to the 23S rRNA
E3U44_RS09265	COG0201	protein transport
E3U44_RS09270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3U44_RS09275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3U44_RS09280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3U44_RS09285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3U44_RS09290	COG0202	RNA polymerase activity
E3U44_RS09295	COG0203	ribosomal protein L17
E3U44_RS09305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3U44_RS09310	COG0402	S-adenosylhomocysteine deaminase activity
E3U44_RS09320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E3U44_RS09330	COG0730	response to heat
E3U44_RS09335	COG0175	sulfate reduction
E3U44_RS09340	COG0175	sulfate reduction
E3U44_RS09360	COG1993	acr, cog1993
E3U44_RS09365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3U44_RS09390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3U44_RS09405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E3U44_RS09410	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3U44_RS09415	COG1238	metal cluster binding
E3U44_RS09430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3U44_RS09435	COG1381	Involved in DNA repair and RecF pathway recombination
E3U44_RS09440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E3U44_RS09445	COG0736	holo-[acyl-carrier-protein] synthase activity
E3U44_RS09470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3U44_RS09480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3U44_RS09485	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3U44_RS09490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3U44_RS09495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3U44_RS09500	COG0024	Methionine aminopeptidase
E3U44_RS09505	COG0052	Belongs to the universal ribosomal protein uS2 family
E3U44_RS09510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3U44_RS09515	COG0528	UMP kinase activity
E3U44_RS09520	COG0233	cytoplasmic translational termination
E3U44_RS09525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3U44_RS09530	COG0575	Belongs to the CDS family
E3U44_RS09535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3U44_RS09545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U44_RS09555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3U44_RS09560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U44_RS09565	COG2976	Protein conserved in bacteria
E3U44_RS09575	COG1160	GTP binding
E3U44_RS09595	COG2885	chlorophyll binding
E3U44_RS09600	COG1607	acyl-coa hydrolase
E3U44_RS09605	COG1022	Amp-dependent synthetase and ligase
E3U44_RS09610	COG1024	Enoyl-CoA hydratase
E3U44_RS09610	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3U44_RS09655	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3U44_RS09660	COG0366	Alpha amylase catalytic
E3U44_RS09665	COG0366	Alpha amylase catalytic
E3U44_RS09670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3U44_RS09670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3U44_RS09670	COG1703	isobutyryl-CoA mutase activity
E3U44_RS09680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3U44_RS09730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3U44_RS09735	COG0604	alcohol dehydrogenase
E3U44_RS09750	COG0784	Response regulator, receiver
E3U44_RS09750	COG5002	protein histidine kinase activity
E3U44_RS09750	COG2205	protein histidine kinase activity
E3U44_RS09755	COG5002	protein histidine kinase activity
E3U44_RS09760	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E3U44_RS09810	COG3093	addiction module antidote protein HigA
E3U44_RS09930	COG0628	permease
E3U44_RS09935	COG1449	Belongs to the glycosyl hydrolase 57 family
E3U44_RS09955	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS09960	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS09965	COG0488	(ABC) transporter
E3U44_RS09970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U44_RS09975	COG1477	protein flavinylation
E3U44_RS09990	COG1295	ribonuclease BN
E3U44_RS09995	COG3100	YcgL domain-containing protein
E3U44_RS09995	COG0561	phosphatase activity
E3U44_RS10010	COG2204	response regulator
E3U44_RS10020	COG0517	IMP dehydrogenase activity
E3U44_RS10020	COG1125	glycine betaine transport
E3U44_RS10025	COG1174	glycine betaine transport
E3U44_RS10035	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS10040	COG0501	Belongs to the peptidase M48B family
E3U44_RS10045	COG1408	metallophosphoesterase
E3U44_RS10055	COG3228	Belongs to the MtfA family
E3U44_RS10065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E3U44_RS10070	COG4181	ATPase activity
E3U44_RS10085	COG1628	Protein of unknown function DUF99
E3U44_RS10150	COG3551	Protein conserved in bacteria
E3U44_RS10155	COG1215	transferase activity, transferring glycosyl groups
E3U44_RS10175	COG0437	4 iron, 4 sulfur cluster binding
E3U44_RS10215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS10240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E3U44_RS10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3U44_RS10275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3U44_RS10280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3U44_RS10285	COG0077	Prephenate dehydratase
E3U44_RS10285	COG1605	Chorismate mutase
E3U44_RS10290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3U44_RS10295	COG0287	Prephenate dehydrogenase
E3U44_RS10300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3U44_RS10310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3U44_RS10320	COG0776	regulation of translation
E3U44_RS10335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E3U44_RS10345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E3U44_RS10350	COG1393	Belongs to the ArsC family
E3U44_RS10360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E3U44_RS10360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E3U44_RS10365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E3U44_RS10385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3U44_RS10400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3U44_RS10440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U44_RS10450	COG1120	ATPase activity
E3U44_RS10455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U44_RS10460	COG0247	lactate metabolic process
E3U44_RS10465	COG0626	cystathionine gamma-synthase activity
E3U44_RS10470	COG0616	signal peptide processing
E3U44_RS10475	COG0277	FAD linked oxidase domain protein
E3U44_RS10490	COG4251	negative regulation of phosphorylation
E3U44_RS10490	COG5001	Diguanylate cyclase
E3U44_RS10490	COG2203	Gaf domain
E3U44_RS10490	COG3706	GGDEF domain
E3U44_RS10495	COG0825	malonyl-CoA metabolic process
E3U44_RS10500	COG0037	tRNA processing
E3U44_RS10505	COG0504	CTP synthase activity
E3U44_RS10510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E3U44_RS10515	COG0148	phosphopyruvate hydratase activity
E3U44_RS10520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3U44_RS10525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3U44_RS10530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3U44_RS10535	COG0585	pseudouridine synthase activity
E3U44_RS10545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3U44_RS10545	COG1648	precorrin-2 dehydrogenase activity
E3U44_RS10560	COG2096	Adenosyltransferase
E3U44_RS10570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3U44_RS10580	COG0429	hydrolase of the alpha beta-hydrolase fold
E3U44_RS10585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3U44_RS10590	COG0450	alkyl hydroperoxide reductase
E3U44_RS10595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3U44_RS10600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3U44_RS10605	COG0436	Aminotransferase
E3U44_RS10610	COG2226	methyltransferase
E3U44_RS10615	COG1126	abc transporter atp-binding protein
E3U44_RS10620	COG0765	amino acid transport
E3U44_RS10625	COG0765	amino acid transport
E3U44_RS10630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U44_RS10635	COG5285	phytanoyl-CoA dioxygenase
E3U44_RS10640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3U44_RS10660	COG0475	glutathione-regulated potassium exporter activity
E3U44_RS10820	COG3177	Filamentation induced by cAMP protein fic
E3U44_RS10850	COG4566	intracellular signal transduction
E3U44_RS10865	COG0842	Transport permease protein
E3U44_RS10870	COG0842	Transport permease protein
E3U44_RS10875	COG1131	(ABC) transporter
E3U44_RS10895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3U44_RS10900	COG1252	NADH dehydrogenase
E3U44_RS10905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3U44_RS10915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3U44_RS10950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3U44_RS10980	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E3U44_RS10995	COG1404	Belongs to the peptidase S8 family
E3U44_RS11015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E3U44_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS11045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3U44_RS11050	COG4660	Part of a membrane complex involved in electron transport
E3U44_RS11055	COG4659	FMN binding
E3U44_RS11060	COG4658	electron transport chain
E3U44_RS11070	COG2878	Part of a membrane complex involved in electron transport
E3U44_RS11075	COG4657	Part of a membrane complex involved in electron transport
E3U44_RS11080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U44_RS11080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U44_RS11085	COG0489	protein tyrosine kinase activity
E3U44_RS11120	COG0277	FAD linked oxidase domain protein
E3U44_RS11130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3U44_RS11140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3U44_RS11145	COG2171	N-acyltransferase activity
E3U44_RS11150	COG0436	Aminotransferase
E3U44_RS11165	COG0779	Required for maturation of 30S ribosomal subunits
E3U44_RS11170	COG2251	uridine kinase activity
E3U44_RS11170	COG0195	Participates in both transcription termination and antitermination
E3U44_RS11175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3U44_RS11180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3U44_RS11185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3U44_RS11190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3U44_RS11195	COG1185	polyribonucleotide nucleotidyltransferase activity
E3U44_RS11200	COG0058	SHG alpha-glucan phosphorylase activity
E3U44_RS11210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3U44_RS11215	COG2833	Protein of unknown function (DUF455)
E3U44_RS11220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3U44_RS11225	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U44_RS11225	COG0022	dehydrogenase e1 component
E3U44_RS11235	COG0137	argininosuccinate synthase activity
E3U44_RS11245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3U44_RS11255	COG1049	propionate catabolic process, 2-methylcitrate cycle
E3U44_RS11275	COG2915	High frequency lysogenization protein hflD homolog
E3U44_RS11280	COG0482	sulfurtransferase activity
E3U44_RS11285	COG1469	GTP cyclohydrolase I activity
E3U44_RS11290	COG0720	synthase
E3U44_RS11295	COG0142	geranyltranstransferase activity
E3U44_RS11305	COG0196	riboflavin kinase activity
E3U44_RS11310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3U44_RS11330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3U44_RS11340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3U44_RS11345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3U44_RS11350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U44_RS11350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U44_RS11365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3U44_RS11415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E3U44_RS11430	COG0366	Alpha amylase catalytic
E3U44_RS11435	COG3387	PFAM Glycoside hydrolase 15-related
E3U44_RS11440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3U44_RS11450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3U44_RS11455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3U44_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U44_RS11475	COG1472	Belongs to the glycosyl hydrolase 3 family
E3U44_RS11485	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3U44_RS11490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E3U44_RS11495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3U44_RS11535	COG0598	Magnesium transport protein CorA
E3U44_RS11540	COG2205	protein histidine kinase activity
E3U44_RS11545	COG4251	negative regulation of phosphorylation
E3U44_RS11550	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E3U44_RS11590	COG2192	nodulation
E3U44_RS11610	COG0840	transmembrane signaling receptor activity
E3U44_RS11625	COG1819	glycosyl
E3U44_RS11640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U44_RS11650	COG0589	response to stress
E3U44_RS11670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3U44_RS11675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U44_RS11685	COG0037	tRNA processing
E3U44_RS11690	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E3U44_RS11695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U44_RS11705	COG2363	Small membrane protein
E3U44_RS11710	COG2084	Dehydrogenase
E3U44_RS11730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E3U44_RS11770	COG4566	intracellular signal transduction
E3U44_RS11785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3U44_RS11790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3U44_RS11805	COG5505	Protein of unknown function (DUF819)
E3U44_RS11835	COG2983	Belongs to the UPF0260 family
E3U44_RS11840	COG0045	succinate-CoA ligase (ADP-forming) activity
E3U44_RS11840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U44_RS11840	COG1042	CoA-binding domain protein
E3U44_RS11855	COG2076	Multidrug Resistance protein
E3U44_RS11870	COG1546	Belongs to the CinA family
E3U44_RS11870	COG1058	Belongs to the CinA family
E3U44_RS11885	COG1199	ATP-dependent helicase activity
E3U44_RS11900	COG1067	ATP-dependent peptidase activity
E3U44_RS11910	COG2205	protein histidine kinase activity
E3U44_RS11940	COG1742	UPF0060 membrane protein
E3U44_RS11990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3U44_RS12000	COG2132	Multicopper oxidase
E3U44_RS12035	COG2217	Heavy metal translocating P-type atpase
E3U44_RS12040	COG3387	PFAM Glycoside hydrolase 15-related
E3U44_RS12060	COG2132	Multicopper oxidase
E3U44_RS12075	COG4191	Histidine kinase
E3U44_RS12085	COG2217	Heavy metal translocating P-type atpase
E3U44_RS12100	COG0058	SHG alpha-glucan phosphorylase activity
E3U44_RS12110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3U44_RS12115	COG0628	permease
E3U44_RS12165	COG2885	chlorophyll binding
E3U44_RS12165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E3U44_RS12215	COG3842	ATPase activity
E3U44_RS12220	COG0390	transport system, permease component
E3U44_RS12230	COG0501	Belongs to the peptidase M48B family
E3U44_RS12275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U44_RS12295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U44_RS12310	COG2226	methyltransferase
E3U44_RS12330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3U44_RS12330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U44_RS12340	COG1509	lysine 2,3-aminomutase activity
E3U44_RS12350	COG0672	)-iron permease
E3U44_RS12360	COG4615	Cyclic peptide transporter
E3U44_RS12385	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E3U44_RS12395	COG2977	Belongs to the P-Pant transferase superfamily
E3U44_RS12405	COG4774	siderophore transport
E3U44_RS12420	COG0848	biopolymer transport protein
E3U44_RS12450	COG0651	ATP synthesis coupled electron transport
E3U44_RS12455	COG0651	ATP synthesis coupled electron transport
E3U44_RS12460	COG0651	ATP synthesis coupled electron transport
E3U44_RS12480	COG1320	monovalent cation:proton antiporter activity
E3U44_RS12495	COG0589	response to stress
E3U44_RS12510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3U44_RS12535	COG0191	fructose-bisphosphate aldolase activity
E3U44_RS12560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3U44_RS12560	COG4651	solute:proton antiporter activity
E3U44_RS12565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3U44_RS12595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3U44_RS12605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3U44_RS12610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E3U44_RS12660	COG1518	maintenance of DNA repeat elements
E3U44_RS12665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E3U44_RS12705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U44_RS12715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U44_RS12745	COG0523	cobalamin synthesis protein
E3U44_RS12760	COG0443	Heat shock 70 kDa protein
E3U44_RS12765	COG0443	Heat shock 70 kDa protein
E3U44_RS12775	COG0644	oxidoreductase
E3U44_RS12780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3U44_RS12795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U44_RS12795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U44_RS12815	COG1074	ATP-dependent DNA helicase activity
E3U44_RS12835	COG0596	Alpha beta hydrolase
E3U44_RS12840	COG2267	carboxylic ester hydrolase activity
E3U44_RS12855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3U44_RS12860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U44_RS12870	COG0573	inorganic phosphate transmembrane transporter activity
E3U44_RS12875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3U44_RS12880	COG0640	Transcriptional regulator
E3U44_RS12890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS12920	COG1358	cellular component organization or biogenesis
E3U44_RS12950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3U44_RS12960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3U44_RS12975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U44_RS13005	COG1012	belongs to the aldehyde dehydrogenase family
E3U44_RS13020	COG0678	peroxiredoxin activity
E3U44_RS13035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E3U44_RS13050	COG1959	2 iron, 2 sulfur cluster binding
E3U44_RS13055	COG1104	cysteine desulfurase activity
E3U44_RS13060	COG0316	Belongs to the HesB IscA family
E3U44_RS13085	COG5002	protein histidine kinase activity
E3U44_RS13095	COG4566	intracellular signal transduction
E3U44_RS13140	COG2079	MmgE PrpD family protein
E3U44_RS13145	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E3U44_RS13160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS13180	COG0363	glucosamine-6-phosphate deaminase activity
E3U44_RS13185	COG0837	glucose binding
E3U44_RS13190	COG2967	ApaG domain
E3U44_RS13195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E3U44_RS13260	COG1704	LemA family
E3U44_RS13265	COG0501	Belongs to the peptidase M48B family
E3U44_RS13275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E3U44_RS13295	COG3485	protocatechuate 3,4-dioxygenase
E3U44_RS13300	COG3267	Type II secretory pathway component ExeA
E3U44_RS13300	COG3409	Peptidoglycan-binding domain 1 protein
E3U44_RS13315	COG3706	GGDEF domain
E3U44_RS13320	COG0318	PFAM AMP-dependent synthetase and ligase
E3U44_RS13335	COG1408	metallophosphoesterase
E3U44_RS13345	COG0322	excinuclease ABC activity
E3U44_RS13350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3U44_RS13370	COG2199	diguanylate cyclase activity
E3U44_RS13380	COG2199	diguanylate cyclase activity
E3U44_RS13380	COG2202	Pas domain
E3U44_RS13380	COG2200	EAL domain
E3U44_RS13385	COG1297	OPT oligopeptide transporter protein
E3U44_RS13400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E3U44_RS13430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3U44_RS13455	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3U44_RS13460	COG0740	serine-type endopeptidase activity
E3U44_RS13465	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3U44_RS13470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3U44_RS13480	COG1286	toxin biosynthetic process
E3U44_RS13490	COG1399	metal-binding, possibly nucleic acid-binding protein
E3U44_RS13495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3U44_RS13500	COG0416	fatty acid biosynthetic process
E3U44_RS13505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3U44_RS13520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U44_RS13525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U44_RS13535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3U44_RS13555	COG0084	hydrolase, TatD family'
E3U44_RS13560	COG1104	cysteine desulfurase activity
E3U44_RS13580	COG0114	fumarate hydratase activity
E3U44_RS13585	COG0659	secondary active sulfate transmembrane transporter activity
E3U44_RS13595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3U44_RS13600	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E3U44_RS13610	COG1999	signal sequence binding
E3U44_RS13620	COG2234	aminopeptidase activity
E3U44_RS13625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3U44_RS13640	COG2391	methyltransferase activity
E3U44_RS13645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U44_RS13675	COG1534	Rna-binding protein
E3U44_RS13680	COG1295	ribonuclease BN
E3U44_RS13685	COG0330	HflC and HflK could
E3U44_RS13700	COG2104	thiamine diphosphate biosynthetic process
E3U44_RS13700	COG2022	thiamine diphosphate biosynthetic process
E3U44_RS13760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3U44_RS13760	COG1796	DNA polymerase
E3U44_RS13775	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3U44_RS13790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3U44_RS13790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3U44_RS13810	COG0419	ATPase involved in DNA repair
E3U44_RS13815	COG0420	3'-5' exonuclease activity
E3U44_RS13820	COG2205	protein histidine kinase activity
E3U44_RS13820	COG0784	Response regulator, receiver
E3U44_RS13825	COG0527	aspartate kinase activity
E3U44_RS13830	COG1917	Cupin 2, conserved barrel domain protein
E3U44_RS13840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3U44_RS13845	COG0285	dihydrofolate synthase activity
E3U44_RS13850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E3U44_RS13855	COG0159	tryptophan synthase activity
E3U44_RS13860	COG0133	tryptophan synthase activity
E3U44_RS13865	COG0135	phosphoribosylanthranilate isomerase activity
E3U44_RS13870	COG0101	tRNA pseudouridine synthase activity
E3U44_RS13880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3U44_RS13885	COG0473	3-isopropylmalate dehydrogenase activity
E3U44_RS13890	COG0066	3-isopropylmalate dehydratase activity
E3U44_RS13905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3U44_RS13905	COG1796	DNA polymerase
E3U44_RS13925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3U44_RS13950	COG0475	glutathione-regulated potassium exporter activity
E3U44_RS13960	COG4251	negative regulation of phosphorylation
E3U44_RS13965	COG0784	Response regulator, receiver
E3U44_RS13970	COG4191	Histidine kinase
E3U44_RS13970	COG0784	Response regulator, receiver
E3U44_RS14005	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E3U44_RS14010	COG1193	negative regulation of DNA recombination
E3U44_RS14025	COG0795	lipopolysaccharide-transporting ATPase activity
E3U44_RS14030	COG0795	lipopolysaccharide-transporting ATPase activity
E3U44_RS14035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3U44_RS14085	COG2918	glutathione biosynthetic process
E3U44_RS14090	COG1397	ADP-ribosylglycohydrolase
E3U44_RS14095	COG1881	PFAM PEBP family protein
E3U44_RS14100	COG0070	glutamate synthase
E3U44_RS14100	COG0067	glutamate synthase
E3U44_RS14100	COG0069	glutamate synthase activity
E3U44_RS14110	COG0656	L-ascorbic acid biosynthetic process
E3U44_RS14120	COG2340	Cysteine-rich secretory protein family
E3U44_RS14145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3U44_RS14280	COG0776	regulation of translation
E3U44_RS14285	COG0072	phenylalanine-tRNA ligase activity
E3U44_RS14290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3U44_RS14295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3U44_RS14300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3U44_RS14310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3U44_RS14320	COG0556	nucleotide-excision repair
E3U44_RS14325	COG0436	Aminotransferase
E3U44_RS14335	COG1525	nuclease
E3U44_RS14355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3U44_RS14365	COG3338	carbonate dehydratase activity
E3U44_RS14370	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U44_RS14375	COG0022	dehydrogenase e1 component
E3U44_RS14385	COG0430	RNA-3'-phosphate cyclase activity
E3U44_RS14390	COG1294	oxidase, subunit
E3U44_RS14415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS14420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS14425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS14425	COG0649	NAD binding
E3U44_RS14445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E3U44_RS14450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3U44_RS14460	COG0713	ATP synthesis coupled electron transport
E3U44_RS14475	COG1007	ATP synthesis coupled electron transport
E3U44_RS14520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3U44_RS14525	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS14555	COG2832	Protein of unknown function (DUF454)
E3U44_RS14595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U44_RS14610	COG1959	2 iron, 2 sulfur cluster binding
E3U44_RS14625	COG0326	Molecular chaperone. Has ATPase activity
E3U44_RS14630	COG0033	Phosphoglucomutase
E3U44_RS14635	COG0439	Biotin carboxylase
E3U44_RS14640	COG0511	ligase activity, forming carbon-carbon bonds
E3U44_RS14640	COG5016	pyruvate
E3U44_RS14645	COG0424	maF-like protein
E3U44_RS14650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3U44_RS14655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E3U44_RS14660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U44_RS14665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E3U44_RS14680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U44_RS14700	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3U44_RS14700	COG1024	Enoyl-CoA hydratase
E3U44_RS14705	COG0183	Belongs to the thiolase family
E3U44_RS14715	COG0427	acetyl-CoA hydrolase
E3U44_RS14720	COG2135	peptidase activity
E3U44_RS14730	COG0525	valine-tRNA ligase activity
E3U44_RS14765	COG1573	uracil-dna glycosylase
E3U44_RS14770	COG0531	amino acid
E3U44_RS14775	COG0189	ligase activity
E3U44_RS14785	COG4067	protein conserved in archaea
E3U44_RS14785	COG0189	ligase activity
E3U44_RS14800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U44_RS14800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U44_RS14815	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS14870	COG2267	carboxylic ester hydrolase activity
E3U44_RS14875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3U44_RS14885	COG5001	Diguanylate cyclase
E3U44_RS14910	COG4279	zinc finger
E3U44_RS14915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3U44_RS14945	COG0598	Magnesium transport protein CorA
E3U44_RS14960	COG1458	PINc domain ribonuclease
E3U44_RS14980	COG1067	ATP-dependent peptidase activity
E3U44_RS14995	COG0398	Pfam SNARE associated Golgi protein
E3U44_RS15065	COG2823	Periplasmic or secreted lipoprotein
E3U44_RS15080	COG4566	intracellular signal transduction
E3U44_RS15105	COG3237	CsbD-like
E3U44_RS15120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3U44_RS15130	COG1335	isochorismatase
E3U44_RS15135	COG0671	phosphoesterase, PA-phosphatase related
E3U44_RS15140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3U44_RS15160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U44_RS15160	COG0045	succinate-CoA ligase (ADP-forming) activity
E3U44_RS15160	COG1042	CoA-binding domain protein
E3U44_RS15175	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
E3U44_RS15185	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
E3U44_RS15195	COG2823	Periplasmic or secreted lipoprotein
E3U44_RS15235	COG0366	Alpha amylase catalytic
E3U44_RS15250	COG0628	permease
E3U44_RS15265	COG2010	Cytochrome c
E3U44_RS15265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U44_RS15270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS15290	COG1652	LysM domain
E3U44_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS15300	COG0028	Belongs to the TPP enzyme family
E3U44_RS15310	COG0247	lactate metabolic process
E3U44_RS15310	COG0277	FAD linked oxidase domain protein
E3U44_RS15325	COG4572	Cation transport regulator
E3U44_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS15340	COG0596	Alpha beta hydrolase
E3U44_RS15360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3U44_RS15365	COG0406	alpha-ribazole phosphatase activity
E3U44_RS15375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS15400	COG1032	radical SAM domain protein
E3U44_RS15405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS15410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS15430	COG1295	ribonuclease BN
E3U44_RS15440	COG2010	Cytochrome c
E3U44_RS15440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E3U44_RS15450	COG2010	Cytochrome c
E3U44_RS15450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U44_RS15455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U44_RS15465	COG1295	ribonuclease BN
E3U44_RS15500	COG1597	lipid kinase activity
E3U44_RS15530	COG0574	Belongs to the PEP-utilizing enzyme family
E3U44_RS15530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3U44_RS15540	COG0714	Associated with various cellular activities
E3U44_RS15550	COG4566	intracellular signal transduction
E3U44_RS15620	COG3335	DDE superfamily endonuclease
E3U44_RS15705	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
E3U44_RS15715	COG0730	response to heat
E3U44_RS15720	COG0475	glutathione-regulated potassium exporter activity
E3U44_RS15725	COG1615	UPF0182 protein
E3U44_RS15730	COG3768	UPF0283 membrane protein
E3U44_RS15735	COG3106	COG3106 Predicted ATPase
E3U44_RS15765	COG2853	Lipoprotein
E3U44_RS15780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3U44_RS15795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E3U44_RS15810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U44_RS15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3U44_RS15845	COG1444	tRNA N-acetyltransferase activity
E3U44_RS15860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3U44_RS15870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3U44_RS15905	COG3344	reverse transcriptase
E3U44_RS15925	COG3385	transposase activity
E3U44_RS15935	COG2255	four-way junction helicase activity
E3U44_RS15950	COG2855	membrane
E3U44_RS15965	COG4251	negative regulation of phosphorylation
E3U44_RS15975	COG0488	(ABC) transporter
E3U44_RS16000	COG0432	Pfam Uncharacterised protein family UPF0047
E3U44_RS16010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3U44_RS16015	COG3115	cell septum assembly
E3U44_RS16020	COG1196	nuclear chromosome segregation
E3U44_RS16025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E3U44_RS16030	COG1070	Carbohydrate kinase
E3U44_RS16035	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
E3U44_RS16045	COG4566	intracellular signal transduction
E3U44_RS16055	COG4251	negative regulation of phosphorylation
E3U44_RS16060	COG0784	Response regulator, receiver
E3U44_RS16075	COG0506	proline dehydrogenase activity
E3U44_RS16075	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3U44_RS16075	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E3U44_RS16080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3U44_RS16090	COG3360	Dodecin
E3U44_RS16100	COG1012	belongs to the aldehyde dehydrogenase family
E3U44_RS16105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3U44_RS16210	COG0277	FAD linked oxidase domain protein
E3U44_RS16210	COG0247	lactate metabolic process
E3U44_RS16215	COG0590	tRNA wobble adenosine to inosine editing
E3U44_RS16225	COG0577	efflux transmembrane transporter activity
E3U44_RS16240	COG4771	TonB-dependent receptor
E3U44_RS16255	COG0028	Belongs to the TPP enzyme family
E3U44_RS16265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3U44_RS16270	COG0351	phosphomethylpyrimidine kinase
E3U44_RS16270	COG0352	thiamine-phosphate diphosphorylase activity
E3U44_RS16290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3U44_RS16305	COG3335	DDE superfamily endonuclease
E3U44_RS16335	COG0302	gtp cyclohydrolase
E3U44_RS16340	COG0121	glutamine amidotransferase
E3U44_RS16350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3U44_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
E3U44_RS16385	COG3706	GGDEF domain
E3U44_RS16385	COG5001	Diguanylate cyclase
E3U44_RS16385	COG2203	Gaf domain
E3U44_RS16385	COG4251	negative regulation of phosphorylation
E3U44_RS16395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E3U44_RS16420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E3U44_RS16425	COG1473	amidohydrolase
E3U44_RS16435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3U44_RS16445	COG0543	2 iron, 2 sulfur cluster binding
E3U44_RS16445	COG0493	'glutamate synthase
E3U44_RS16465	COG0588	phosphoglycerate mutase activity
E3U44_RS16485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E3U44_RS16525	COG0281	malic enzyme
E3U44_RS16525	COG0280	phosphate acetyltransferase
E3U44_RS16535	COG1830	Aldolase
E3U44_RS16560	COG1858	cytochrome C peroxidase
E3U44_RS16595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS16605	COG2852	Protein conserved in bacteria
E3U44_RS16650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U44_RS16660	COG2192	nodulation
E3U44_RS16705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U44_RS16730	COG1086	Polysaccharide biosynthesis protein
E3U44_RS16780	COG0489	protein tyrosine kinase activity
E3U44_RS16780	COG3206	protein involved in exopolysaccharide biosynthesis
E3U44_RS16785	COG4464	protein tyrosine phosphatase activity
E3U44_RS16795	COG0745	RESPONSE REGULATOR receiver
E3U44_RS16810	COG1657	PFAM Prenyltransferase squalene oxidase
E3U44_RS16820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3U44_RS16830	COG0028	Belongs to the TPP enzyme family
E3U44_RS16830	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E3U44_RS16835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3U44_RS16840	COG0724	RNA recognition motif
E3U44_RS16845	COG0308	aminopeptidase N
E3U44_RS16850	COG0501	Belongs to the peptidase M48B family
E3U44_RS16855	COG3038	cytochrome b561
E3U44_RS16865	COG0450	alkyl hydroperoxide reductase
E3U44_RS16870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3U44_RS16875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3U44_RS16885	COG2183	response to ionizing radiation
E3U44_RS16905	COG1643	Atp-dependent helicase
E3U44_RS16910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3U44_RS16945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3U44_RS16970	COG4115	mRNA cleavage
E3U44_RS16985	COG3093	addiction module antidote protein HigA
E3U44_RS16990	COG3344	reverse transcriptase
E3U44_RS17005	COG3012	SEC-C Motif Domain Protein
E3U44_RS17010	COG1403	HNH endonuclease
E3U44_RS17015	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
E3U44_RS17030	COG0693	protein deglycase activity
E3U44_RS17040	COG0702	epimerase
E3U44_RS17055	COG0583	DNA-binding transcription factor activity
E3U44_RS17060	COG0483	inositol monophosphate 1-phosphatase activity
E3U44_RS17065	COG2239	Acts as a magnesium transporter
E3U44_RS17075	COG1032	radical SAM domain protein
E3U44_RS17080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3U44_RS17100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3U44_RS17105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3U44_RS17110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3U44_RS17135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3U44_RS17140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U44_RS17150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U44_RS17155	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U44_RS17165	COG0673	inositol 2-dehydrogenase activity
E3U44_RS17175	COG0596	Alpha beta hydrolase
E3U44_RS17180	COG1716	ATPase activity
E3U44_RS17195	COG0625	glutathione transferase activity
E3U44_RS17205	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E3U44_RS17220	COG3483	tryptophan 2,3-dioxygenase activity
E3U44_RS17230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3U44_RS17255	COG0372	Belongs to the citrate synthase family
E3U44_RS17260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3U44_RS17270	COG0589	response to stress
E3U44_RS17275	COG1183	phosphatidylcholine synthase activity
E3U44_RS17285	COG1136	(ABC) transporter
E3U44_RS17295	COG0577	efflux transmembrane transporter activity
E3U44_RS17320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3U44_RS17360	COG0671	phosphoesterase, PA-phosphatase related
E3U44_RS17365	COG1757	Na H antiporter
E3U44_RS17390	COG0693	protein deglycase activity
E3U44_RS17430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U44_RS17445	COG1131	(ABC) transporter
E3U44_RS17455	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U44_RS17500	COG4185	zeta toxin
E3U44_RS17575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3U44_RS17585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3U44_RS17590	COG2137	regulation of response to DNA damage stimulus
E3U44_RS17595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3U44_RS17600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E3U44_RS17605	COG1546	Belongs to the CinA family
E3U44_RS17610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E3U44_RS17615	COG2226	methyltransferase
E3U44_RS17680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3U44_RS17685	COG0739	heme binding
E3U44_RS17690	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E3U44_RS17695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3U44_RS17700	COG0509	glycine decarboxylation via glycine cleavage system
E3U44_RS17710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3U44_RS17715	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3U44_RS17720	COG0166	Belongs to the GPI family
E3U44_RS17725	COG0124	histidyl-tRNA synthetase
E3U44_RS17740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3U44_RS17745	COG0105	UTP biosynthetic process
E3U44_RS17750	COG0442	prolyl-tRNA aminoacylation
E3U44_RS17755	COG0741	lytic transglycosylase activity
E3U44_RS17760	COG3005	denitrification pathway
E3U44_RS17765	COG0737	Belongs to the 5'-nucleotidase family
E3U44_RS17775	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E3U44_RS17810	COG1254	Belongs to the acylphosphatase family
E3U44_RS17815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E3U44_RS17820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3U44_RS17825	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3U44_RS17830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3U44_RS17835	COG0617	tRNA 3'-terminal CCA addition
E3U44_RS17870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3U44_RS17875	COG0459	protein refolding
E3U44_RS17880	COG0438	transferase activity, transferring glycosyl groups
E3U44_RS17895	COG0189	ligase activity
E3U44_RS17895	COG4067	protein conserved in archaea
E3U44_RS17900	COG0189	ligase activity
E3U44_RS17915	COG0477	Major facilitator Superfamily
E3U44_RS17925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E3U44_RS17930	COG2234	aminopeptidase activity
E3U44_RS17940	COG0432	Pfam Uncharacterised protein family UPF0047
E3U44_RS17945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3U44_RS17960	COG4206	TonB-dependent receptor
E3U44_RS17970	COG0406	alpha-ribazole phosphatase activity
E3U44_RS18060	COG1598	PFAM Uncharacterised protein family UPF0150
E3U44_RS18065	COG0668	transmembrane transport
E3U44_RS18180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3U44_RS18250	COG3335	DDE superfamily endonuclease
E3U44_RS18270	COG0582	viral genome integration into host DNA
E3U44_RS18315	COG0484	heat shock protein binding
E3U44_RS18345	COG1598	PFAM Uncharacterised protein family UPF0150
E3U44_RS18355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E3U44_RS18365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E3U44_RS18410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3U44_RS18415	COG0215	cysteine-tRNA ligase activity
E3U44_RS18420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3U44_RS18425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3U44_RS18430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E3U44_RS18435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3U44_RS18440	COG1666	GTP binding
E3U44_RS18445	COG4974	Belongs to the 'phage' integrase family
E3U44_RS18450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3U44_RS18450	COG2169	Transcriptional regulator
E3U44_RS18455	COG0335	large ribosomal subunit rRNA binding
E3U44_RS18460	COG0336	Belongs to the RNA methyltransferase TrmD family
E3U44_RS18465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3U44_RS18470	COG0228	four-way junction DNA binding
E3U44_RS18475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3U44_RS18480	COG4137	Cytochrome C assembly protein
E3U44_RS18485	COG4536	flavin adenine dinucleotide binding
E3U44_RS18505	COG1194	a g-specific adenine glycosylase
E3U44_RS18510	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E3U44_RS18560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3U44_RS18565	COG1489	DNA binding
E3U44_RS18575	COG0753	catalase activity
E3U44_RS18590	COG3549	Plasmid maintenance system killer
E3U44_RS18630	COG0004	ammonium transporteR
E3U44_RS18660	COG3335	DDE superfamily endonuclease
E3U44_RS18735	COG2361	Protein of unknown function DUF86
E3U44_RS18740	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E3U44_RS18745	COG0582	viral genome integration into host DNA
E3U44_RS18755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3U44_RS18760	COG0733	neurotransmitter:sodium symporter activity
E3U44_RS18765	COG2867	negative regulation of translational initiation
E3U44_RS18770	COG2914	Belongs to the UPF0125 (RnfH) family
E3U44_RS18780	COG0735	belongs to the Fur family
E3U44_RS18790	COG2095	MarC family integral membrane protein
E3U44_RS18795	COG0497	DNA recombination
E3U44_RS18800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3U44_RS18805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3U44_RS18820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3U44_RS18830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3U44_RS18835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3U44_RS18840	COG0717	Belongs to the dCTP deaminase family
E3U44_RS18845	COG1862	Preprotein translocase
E3U44_RS18860	COG0463	Glycosyl transferase, family 2
E3U44_RS18870	COG0471	metal ion transport
E3U44_RS18870	COG3273	potassium ion transport
E3U44_RS18880	COG1765	OsmC-like protein
E3U44_RS18890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E3U44_RS18905	COG4133	protoheme IX ABC transporter activity
E3U44_RS18925	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E3U44_RS18935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U44_RS18955	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E3U44_RS18960	COG0247	lactate metabolic process
E3U44_RS18980	COG0318	PFAM AMP-dependent synthetase and ligase
E3U44_RS19000	COG1404	Belongs to the peptidase S8 family
E3U44_RS19010	COG1525	nuclease
E3U44_RS19060	COG4983	Phage plasmid primase, P4 family domain protein
E3U44_RS19090	COG1404	Belongs to the peptidase S8 family
E3U44_RS19100	COG1525	nuclease