locus-tag	class	description
NWAT_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NWAT_RS00015	COG0592	DNA-directed DNA polymerase activity
NWAT_RS00070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NWAT_RS00075	COG0187	DNA topoisomerase II activity
NWAT_RS00090	COG3293	Transposase
NWAT_RS00100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NWAT_RS00105	COG2218	PFAM glutamate synthase alpha subunit domain protein
NWAT_RS00110	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
NWAT_RS00115	COG1229	Formylmethanofuran dehydrogenase subunit A
NWAT_RS00130	COG0018	arginyl-trna synthetase
NWAT_RS00135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NWAT_RS00140	COG0693	protein deglycase activity
NWAT_RS00145	COG0793	Belongs to the peptidase S41A family
NWAT_RS00150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NWAT_RS00155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NWAT_RS00160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NWAT_RS00165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NWAT_RS00170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NWAT_RS00185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NWAT_RS00195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NWAT_RS00200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NWAT_RS00205	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NWAT_RS00210	COG1610	YqeY-like protein
NWAT_RS00215	COG0358	DNA primase activity
NWAT_RS00265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NWAT_RS00305	COG2094	Belongs to the DNA glycosylase MPG family
NWAT_RS00345	COG3093	addiction module antidote protein HigA
NWAT_RS00355	COG1598	PFAM Uncharacterised protein family UPF0150
NWAT_RS00405	COG0297	glycogen (starch) synthase activity
NWAT_RS00450	COG2116	formate transmembrane transporter activity
NWAT_RS00460	COG0508	dehydrogenase complex catalyzes the overall conversion of
NWAT_RS00465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NWAT_RS00470	COG1132	(ABC) transporter
NWAT_RS00480	COG1253	flavin adenine dinucleotide binding
NWAT_RS00485	COG1253	flavin adenine dinucleotide binding
NWAT_RS00505	COG1566	PFAM secretion protein HlyD family protein
NWAT_RS00510	COG2814	Major facilitator Superfamily
NWAT_RS00525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NWAT_RS00535	COG2201	protein-glutamate methylesterase activity
NWAT_RS00540	COG0643	Histidine kinase
NWAT_RS00540	COG0784	Response regulator, receiver
NWAT_RS00540	COG2198	Histidine kinase
NWAT_RS00550	COG0840	transmembrane signaling receptor activity
NWAT_RS00585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NWAT_RS00595	COG0217	transcriptional regulatory protein
NWAT_RS00600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NWAT_RS00605	COG0632	four-way junction helicase activity
NWAT_RS00610	COG2255	four-way junction helicase activity
NWAT_RS00615	COG0824	Thioesterase
NWAT_RS00635	COG0823	Involved in the tonB-independent uptake of proteins
NWAT_RS00640	COG2885	chlorophyll binding
NWAT_RS00645	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
NWAT_RS00650	COG0602	queuosine metabolic process
NWAT_RS00655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NWAT_RS00690	COG2081	HI0933 family
NWAT_RS00695	COG1272	protein, Hemolysin III
NWAT_RS00720	COG3608	succinylglutamate desuccinylase aspartoacylase
NWAT_RS00725	COG0668	transmembrane transport
NWAT_RS00755	COG0672	)-iron permease
NWAT_RS00795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NWAT_RS00815	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NWAT_RS00820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NWAT_RS00825	COG0077	Prephenate dehydratase
NWAT_RS00825	COG1605	Chorismate mutase
NWAT_RS00830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NWAT_RS00835	COG0287	Prephenate dehydrogenase
NWAT_RS00840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NWAT_RS00850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NWAT_RS00860	COG0776	regulation of translation
NWAT_RS00875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NWAT_RS00885	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NWAT_RS00890	COG1393	Belongs to the ArsC family
NWAT_RS00900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NWAT_RS00900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NWAT_RS00905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NWAT_RS00930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NWAT_RS00965	COG4185	zeta toxin
NWAT_RS01000	COG4413	Urea transporter
NWAT_RS01005	COG0829	nickel cation binding
NWAT_RS01010	COG0831	urea catabolic process
NWAT_RS01015	COG0832	Belongs to the urease beta subunit family
NWAT_RS01020	COG0804	urea catabolic process
NWAT_RS01025	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NWAT_RS01030	COG0830	nickel cation binding
NWAT_RS01035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NWAT_RS01060	COG2001	Belongs to the MraZ family
NWAT_RS01065	COG0275	rRNA processing
NWAT_RS01080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NWAT_RS01085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NWAT_RS01090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NWAT_RS01095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NWAT_RS01100	COG0772	Belongs to the SEDS family
NWAT_RS01105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NWAT_RS01110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NWAT_RS01115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NWAT_RS01120	COG1181	Belongs to the D-alanine--D-alanine ligase family
NWAT_RS01140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NWAT_RS01150	COG0739	heme binding
NWAT_RS01150	COG0741	lytic transglycosylase activity
NWAT_RS01150	COG1196	nuclear chromosome segregation
NWAT_RS01155	COG0653	protein targeting
NWAT_RS01160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NWAT_RS01170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NWAT_RS01175	COG0563	adenylate kinase activity
NWAT_RS01180	COG0205	6-phosphofructokinase activity
NWAT_RS01195	COG1530	ribonuclease E activity
NWAT_RS01200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NWAT_RS01210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NWAT_RS01215	COG1611	Belongs to the LOG family
NWAT_RS01220	COG0778	Nitroreductase
NWAT_RS01230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NWAT_RS01235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NWAT_RS01240	COG1968	undecaprenyl-diphosphatase activity
NWAT_RS01250	COG0842	Transport permease protein
NWAT_RS01255	COG1131	(ABC) transporter
NWAT_RS01260	COG3066	DNA modification
NWAT_RS01270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NWAT_RS01280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NWAT_RS01290	COG3954	Phosphoribulokinase
NWAT_RS01295	COG0009	L-threonylcarbamoyladenylate synthase
NWAT_RS01300	COG0408	coproporphyrinogen oxidase activity
NWAT_RS01305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NWAT_RS01310	COG0167	dihydroorotate dehydrogenase activity
NWAT_RS01330	COG2226	methyltransferase
NWAT_RS01345	COG0328	RNA-DNA hybrid ribonuclease activity
NWAT_RS01350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NWAT_RS01355	COG1420	regulation of RNA biosynthetic process
NWAT_RS01360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NWAT_RS01365	COG0443	Heat shock 70 kDa protein
NWAT_RS01370	COG0484	heat shock protein binding
NWAT_RS01375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NWAT_RS01385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NWAT_RS01390	COG0126	phosphoglycerate kinase activity
NWAT_RS01395	COG0469	pyruvate kinase activity
NWAT_RS01400	COG0191	fructose-bisphosphate aldolase activity
NWAT_RS01405	COG2814	Major facilitator Superfamily
NWAT_RS01410	COG0039	L-malate dehydrogenase activity
NWAT_RS01415	COG2239	Acts as a magnesium transporter
NWAT_RS01420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NWAT_RS01425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NWAT_RS01435	COG1660	Displays ATPase and GTPase activities
NWAT_RS01455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NWAT_RS01460	COG1137	ATPase activity
NWAT_RS01465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NWAT_RS01475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NWAT_RS01485	COG2853	Lipoprotein
NWAT_RS01490	COG1127	ABC transporter
NWAT_RS01495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NWAT_RS01500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NWAT_RS01520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NWAT_RS01525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NWAT_RS01530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NWAT_RS01535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NWAT_RS01550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NWAT_RS01550	COG3153	acetyltransferase
NWAT_RS01560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NWAT_RS01565	COG0601	transmembrane transport
NWAT_RS01570	COG0747	negative chemotaxis
NWAT_RS01615	COG0724	RNA recognition motif
NWAT_RS01635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NWAT_RS01640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NWAT_RS01645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NWAT_RS01650	COG2003	Belongs to the UPF0758 family
NWAT_RS01655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NWAT_RS01660	COG1702	phosphate starvation-inducible protein PhoH
NWAT_RS01665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NWAT_RS01670	COG4535	Mg2 and Co2 transporter CorC
NWAT_RS01675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NWAT_RS01680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NWAT_RS01685	COG0281	malic enzyme
NWAT_RS01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NWAT_RS01730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NWAT_RS01755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NWAT_RS01775	COG0189	ligase activity
NWAT_RS01785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NWAT_RS01790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NWAT_RS01800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NWAT_RS01830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NWAT_RS01835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NWAT_RS01840	COG0671	phosphoesterase, PA-phosphatase related
NWAT_RS01845	COG1335	isochorismatase
NWAT_RS01850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NWAT_RS01855	COG2204	response regulator
NWAT_RS01860	COG3237	CsbD-like
NWAT_RS01885	COG2823	Periplasmic or secreted lipoprotein
NWAT_RS01930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NWAT_RS01935	COG2969	positive regulation of protein catabolic process
NWAT_RS01940	COG0625	glutathione transferase activity
NWAT_RS01945	COG2857	Cytochrome c1
NWAT_RS01950	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NWAT_RS01955	COG0723	plastoquinol--plastocyanin reductase activity
NWAT_RS01965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NWAT_RS01970	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NWAT_RS01985	COG0494	nUDIX hydrolase
NWAT_RS01995	COG0237	dephospho-CoA kinase activity
NWAT_RS02000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NWAT_RS02015	COG0019	diaminopimelate decarboxylase activity
NWAT_RS02020	COG4106	trans-aconitate 2-methyltransferase activity
NWAT_RS02025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NWAT_RS02035	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NWAT_RS02060	COG3588	fructose-bisphosphate aldolase
NWAT_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
NWAT_RS02105	COG0732	type I restriction modification DNA specificity domain
NWAT_RS02110	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NWAT_RS02135	COG5001	Diguanylate cyclase
NWAT_RS02135	COG5002	protein histidine kinase activity
NWAT_RS02145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NWAT_RS02150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NWAT_RS02155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NWAT_RS02160	COG2835	tetraacyldisaccharide 4'-kinase activity
NWAT_RS02165	COG1663	tetraacyldisaccharide 4'-kinase activity
NWAT_RS02170	COG1132	(ABC) transporter
NWAT_RS02175	COG0848	biopolymer transport protein
NWAT_RS02180	COG0811	peptide transport
NWAT_RS02185	COG2333	competence protein COMEC
NWAT_RS02185	COG0658	competence protein
NWAT_RS02195	COG1136	(ABC) transporter
NWAT_RS02200	COG4591	ABC-type transport system involved in lipoprotein release permease component
NWAT_RS02210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NWAT_RS02215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NWAT_RS02220	COG0495	leucyl-tRNA aminoacylation
NWAT_RS02225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NWAT_RS02230	COG1466	dna polymerase III delta subunit
NWAT_RS02235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NWAT_RS02240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NWAT_RS02250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NWAT_RS02255	COG0424	maF-like protein
NWAT_RS02280	COG0425	Belongs to the sulfur carrier protein TusA family
NWAT_RS02285	COG0174	glutamine synthetase
NWAT_RS02305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NWAT_RS02325	COG1131	(ABC) transporter
NWAT_RS02340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NWAT_RS02345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NWAT_RS02360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NWAT_RS02365	COG0154	amidase activity
NWAT_RS02370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NWAT_RS02375	COG2951	lytic endotransglycosylase activity
NWAT_RS02385	COG1686	Belongs to the peptidase S11 family
NWAT_RS02395	COG0321	lipoyl(octanoyl) transferase activity
NWAT_RS02400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NWAT_RS02415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NWAT_RS02420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NWAT_RS02430	COG0535	radical SAM domain protein
NWAT_RS02445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NWAT_RS02450	COG4783	chaperone-mediated protein folding
NWAT_RS02455	COG0425	Belongs to the sulfur carrier protein TusA family
NWAT_RS02460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NWAT_RS02465	COG1538	Outer membrane efflux protein
NWAT_RS02470	COG1519	Transferase
NWAT_RS02475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NWAT_RS02480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NWAT_RS02480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NWAT_RS02495	COG0724	RNA recognition motif
NWAT_RS02520	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS02525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NWAT_RS02550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NWAT_RS02555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NWAT_RS02560	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NWAT_RS02565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NWAT_RS02570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NWAT_RS02575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NWAT_RS02580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NWAT_RS02600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NWAT_RS02605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NWAT_RS02610	COG1923	regulation of RNA biosynthetic process
NWAT_RS02615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NWAT_RS02620	COG0330	HflC and HflK could
NWAT_RS02625	COG0330	HflC and HflK could
NWAT_RS02630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NWAT_RS02635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NWAT_RS02640	COG4520	surface antigen
NWAT_RS02650	COG0513	Belongs to the DEAD box helicase family
NWAT_RS02655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NWAT_RS02660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NWAT_RS02665	COG0006	proline dipeptidase activity
NWAT_RS02685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NWAT_RS02695	COG0505	Belongs to the CarA family
NWAT_RS02700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NWAT_RS02705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NWAT_RS02710	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NWAT_RS02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NWAT_RS02725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NWAT_RS02730	COG0149	triose-phosphate isomerase activity
NWAT_RS02745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS02750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS02755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS02760	COG0649	NAD binding
NWAT_RS02765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NWAT_RS02780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NWAT_RS02785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS02795	COG0713	ATP synthesis coupled electron transport
NWAT_RS02810	COG1007	ATP synthesis coupled electron transport
NWAT_RS02815	COG0604	alcohol dehydrogenase
NWAT_RS02825	COG1331	Highly conserved protein containing a thioredoxin domain
NWAT_RS02830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NWAT_RS02835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NWAT_RS02840	COG3293	Transposase
NWAT_RS02870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NWAT_RS02890	COG1166	arginine decarboxylase activity
NWAT_RS02895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NWAT_RS02930	COG1238	metal cluster binding
NWAT_RS02965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NWAT_RS02975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NWAT_RS02980	COG2716	regulation of RNA biosynthetic process
NWAT_RS02985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NWAT_RS02990	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
NWAT_RS02995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NWAT_RS03000	COG0418	dihydroorotase activity
NWAT_RS03005	COG0028	Belongs to the TPP enzyme family
NWAT_RS03010	COG0440	acetolactate synthase activity
NWAT_RS03015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NWAT_RS03020	COG1183	phosphatidylcholine synthase activity
NWAT_RS03025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NWAT_RS03030	COG1573	uracil-dna glycosylase
NWAT_RS03035	COG0456	acetyltransferase
NWAT_RS03040	COG3174	membrane
NWAT_RS03045	COG0494	nUDIX hydrolase
NWAT_RS03050	COG0730	response to heat
NWAT_RS03055	COG2766	serine protein kinase
NWAT_RS03060	COG2718	Belongs to the UPF0229 family
NWAT_RS03065	COG2719	SpoVR family
NWAT_RS03080	COG0560	Phosphoserine phosphatase
NWAT_RS03115	COG0134	indole-3-glycerol-phosphate synthase activity
NWAT_RS03120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NWAT_RS03125	COG0512	Glutamine amidotransferase of anthranilate synthase
NWAT_RS03135	COG0546	phosphoglycolate phosphatase activity
NWAT_RS03140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NWAT_RS03145	COG1959	2 iron, 2 sulfur cluster binding
NWAT_RS03150	COG0719	Fe-S assembly protein
NWAT_RS03155	COG0396	ATPase activity
NWAT_RS03160	COG0719	Fe-S assembly protein
NWAT_RS03165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NWAT_RS03170	COG0822	iron-sulfur transferase activity
NWAT_RS03190	COG0529	Catalyzes the synthesis of activated sulfate
NWAT_RS03200	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS03205	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS03210	COG0367	asparagine synthase
NWAT_RS03215	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS03220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NWAT_RS03225	COG0776	regulation of translation
NWAT_RS03240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NWAT_RS03245	COG1053	succinate dehydrogenase
NWAT_RS03250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NWAT_RS03255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NWAT_RS03280	COG3026	antisigma factor binding
NWAT_RS03290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NWAT_RS03295	COG0481	GTPase activity
NWAT_RS03300	COG0681	Belongs to the peptidase S26 family
NWAT_RS03310	COG0571	ribonuclease III activity
NWAT_RS03315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NWAT_RS03325	COG0436	Aminotransferase
NWAT_RS03335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NWAT_RS03340	COG4191	Histidine kinase
NWAT_RS03345	COG0784	Response regulator, receiver
NWAT_RS03350	COG4191	Histidine kinase
NWAT_RS03355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NWAT_RS03360	COG2957	Belongs to the agmatine deiminase family
NWAT_RS03365	COG0471	metal ion transport
NWAT_RS03375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NWAT_RS03385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NWAT_RS03400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NWAT_RS03405	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NWAT_RS03415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NWAT_RS03445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NWAT_RS03450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NWAT_RS03455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NWAT_RS03460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NWAT_RS03465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NWAT_RS03470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NWAT_RS03475	COG0542	response to heat
NWAT_RS03480	COG0735	belongs to the Fur family
NWAT_RS03485	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NWAT_RS03490	COG1121	(ABC) transporter
NWAT_RS03495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NWAT_RS03500	COG0494	nUDIX hydrolase
NWAT_RS03505	COG1218	3'(2'),5'-bisphosphate nucleotidase
NWAT_RS03520	COG0745	RESPONSE REGULATOR receiver
NWAT_RS03535	COG0573	inorganic phosphate transmembrane transporter activity
NWAT_RS03545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NWAT_RS03550	COG0704	Plays a role in the regulation of phosphate uptake
NWAT_RS03560	COG3025	triphosphatase activity
NWAT_RS03580	COG2863	cytochrome
NWAT_RS03585	COG3258	Cytochrome c
NWAT_RS03590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NWAT_RS03600	COG0429	hydrolase of the alpha beta-hydrolase fold
NWAT_RS03605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NWAT_RS03630	COG0450	alkyl hydroperoxide reductase
NWAT_RS03640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NWAT_RS03645	COG0436	Aminotransferase
NWAT_RS03660	COG0617	tRNA 3'-terminal CCA addition
NWAT_RS03665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NWAT_RS03670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NWAT_RS03675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NWAT_RS03680	COG1254	Belongs to the acylphosphatase family
NWAT_RS03700	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NWAT_RS03710	COG0737	Belongs to the 5'-nucleotidase family
NWAT_RS03715	COG3005	denitrification pathway
NWAT_RS03720	COG0741	lytic transglycosylase activity
NWAT_RS03725	COG0442	prolyl-tRNA aminoacylation
NWAT_RS03735	COG0105	UTP biosynthetic process
NWAT_RS03740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NWAT_RS03750	COG0124	histidyl-tRNA synthetase
NWAT_RS03755	COG0166	Belongs to the GPI family
NWAT_RS03760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NWAT_RS03765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NWAT_RS03775	COG0509	glycine decarboxylation via glycine cleavage system
NWAT_RS03780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NWAT_RS03785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NWAT_RS03790	COG0739	heme binding
NWAT_RS03795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NWAT_RS03850	COG1214	PFAM Peptidase M22, glycoprotease
NWAT_RS03860	COG2226	methyltransferase
NWAT_RS03865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NWAT_RS03880	COG1546	Belongs to the CinA family
NWAT_RS03885	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NWAT_RS03890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NWAT_RS03895	COG2137	regulation of response to DNA damage stimulus
NWAT_RS03900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NWAT_RS03910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NWAT_RS03920	COG1874	Beta-galactosidase
NWAT_RS03920	COG0366	Alpha amylase catalytic
NWAT_RS03935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NWAT_RS03940	COG0601	transmembrane transport
NWAT_RS03945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NWAT_RS03955	COG4172	Belongs to the ABC transporter superfamily
NWAT_RS03960	COG0247	lactate metabolic process
NWAT_RS03965	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NWAT_RS03985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NWAT_RS03995	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NWAT_RS04015	COG4133	protoheme IX ABC transporter activity
NWAT_RS04025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NWAT_RS04030	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NWAT_RS04040	COG1765	OsmC-like protein
NWAT_RS04110	COG3119	arylsulfatase activity
NWAT_RS04125	COG4191	Histidine kinase
NWAT_RS04160	COG3119	arylsulfatase activity
NWAT_RS04205	COG0861	Integral membrane protein TerC family
NWAT_RS04215	COG2226	methyltransferase
NWAT_RS04220	COG0142	geranyltranstransferase activity
NWAT_RS04230	COG5001	Diguanylate cyclase
NWAT_RS04230	COG5002	protein histidine kinase activity
NWAT_RS04245	COG2154	pterin-4-alpha-carbinolamine dehydratase
NWAT_RS04280	COG0714	Associated with various cellular activities
NWAT_RS04285	COG2326	polyphosphate kinase activity
NWAT_RS04295	COG1181	Belongs to the D-alanine--D-alanine ligase family
NWAT_RS04315	COG0577	efflux transmembrane transporter activity
NWAT_RS04315	COG1136	(ABC) transporter
NWAT_RS04325	COG1136	(ABC) transporter
NWAT_RS04330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NWAT_RS04345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NWAT_RS04350	COG0372	Belongs to the citrate synthase family
NWAT_RS04355	COG2079	MmgE PrpD family protein
NWAT_RS04400	COG1073	alpha beta
NWAT_RS04445	COG0601	transmembrane transport
NWAT_RS04450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NWAT_RS04455	COG1472	Belongs to the glycosyl hydrolase 3 family
NWAT_RS04480	COG1215	transferase activity, transferring glycosyl groups
NWAT_RS04490	COG1215	transferase activity, transferring glycosyl groups
NWAT_RS04495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NWAT_RS04560	COG1987	bacterial-type flagellum assembly
NWAT_RS04575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NWAT_RS04610	COG1196	nuclear chromosome segregation
NWAT_RS04610	COG3264	Mechanosensitive ion channel
NWAT_RS04660	COG1131	(ABC) transporter
NWAT_RS04700	COG1757	Na H antiporter
NWAT_RS04725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NWAT_RS04730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NWAT_RS04740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NWAT_RS04745	COG2171	N-acyltransferase activity
NWAT_RS04750	COG0436	Aminotransferase
NWAT_RS04765	COG0779	Required for maturation of 30S ribosomal subunits
NWAT_RS04770	COG0195	Participates in both transcription termination and antitermination
NWAT_RS04770	COG2251	uridine kinase activity
NWAT_RS04775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NWAT_RS04780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NWAT_RS04785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NWAT_RS04790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NWAT_RS04795	COG1185	polyribonucleotide nucleotidyltransferase activity
NWAT_RS04800	COG0058	SHG alpha-glucan phosphorylase activity
NWAT_RS04810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NWAT_RS04815	COG2833	Protein of unknown function (DUF455)
NWAT_RS04820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NWAT_RS04825	COG0508	dehydrogenase complex catalyzes the overall conversion of
NWAT_RS04825	COG0022	dehydrogenase e1 component
NWAT_RS04830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NWAT_RS04835	COG0137	argininosuccinate synthase activity
NWAT_RS04855	COG2169	Transcriptional regulator
NWAT_RS04855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NWAT_RS04865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NWAT_RS04870	COG0156	8-amino-7-oxononanoate synthase activity
NWAT_RS04875	COG2267	carboxylic ester hydrolase activity
NWAT_RS04920	COG3189	MarR family transcriptional regulator
NWAT_RS04935	COG1269	ATP hydrolysis coupled proton transport
NWAT_RS04950	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
NWAT_RS04955	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NWAT_RS04960	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NWAT_RS04965	COG1394	ATPase activity, coupled to movement of substances
NWAT_RS04985	COG2197	response regulator
NWAT_RS05005	COG1966	Carbon starvation protein
NWAT_RS05010	COG2879	small protein
NWAT_RS05015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NWAT_RS05020	COG2363	Small membrane protein
NWAT_RS05045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NWAT_RS05095	COG3240	lipase activity
NWAT_RS05110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NWAT_RS05115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NWAT_RS05140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NWAT_RS05155	COG0628	permease
NWAT_RS05170	COG3158	transport of potassium into the cell
NWAT_RS05180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NWAT_RS05190	COG3387	PFAM Glycoside hydrolase 15-related
NWAT_RS05215	COG2915	High frequency lysogenization protein hflD homolog
NWAT_RS05220	COG0482	sulfurtransferase activity
NWAT_RS05225	COG1469	GTP cyclohydrolase I activity
NWAT_RS05230	COG0720	synthase
NWAT_RS05235	COG0142	geranyltranstransferase activity
NWAT_RS05240	COG1722	exodeoxyribonuclease VII activity
NWAT_RS05245	COG0196	riboflavin kinase activity
NWAT_RS05255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NWAT_RS05265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NWAT_RS05275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NWAT_RS05280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NWAT_RS05285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NWAT_RS05285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NWAT_RS05300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NWAT_RS05305	COG5001	Diguanylate cyclase
NWAT_RS05305	COG5002	protein histidine kinase activity
NWAT_RS05310	COG4636	protein conserved in cyanobacteria
NWAT_RS05315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NWAT_RS05320	COG0494	nUDIX hydrolase
NWAT_RS05360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NWAT_RS05365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NWAT_RS05365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NWAT_RS05370	COG0646	methionine synthase
NWAT_RS05370	COG1410	methionine synthase
NWAT_RS05390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NWAT_RS05400	COG0194	GDP metabolic process
NWAT_RS05405	COG1758	RNA polymerase activity
NWAT_RS05410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NWAT_RS05425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NWAT_RS05460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NWAT_RS05520	COG1215	transferase activity, transferring glycosyl groups
NWAT_RS05525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NWAT_RS05545	COG0437	4 iron, 4 sulfur cluster binding
NWAT_RS05580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NWAT_RS05585	COG1845	cytochrome c oxidase, subunit III
NWAT_RS05590	COG3245	cytochrome
NWAT_RS05610	COG3002	Belongs to the UPF0753 family
NWAT_RS05615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS05630	COG0508	dehydrogenase complex catalyzes the overall conversion of
NWAT_RS05635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NWAT_RS05645	COG0589	response to stress
NWAT_RS05655	COG1408	metallophosphoesterase
NWAT_RS05660	COG4106	trans-aconitate 2-methyltransferase activity
NWAT_RS05665	COG0488	(ABC) transporter
NWAT_RS05680	COG0351	phosphomethylpyrimidine kinase
NWAT_RS05680	COG0352	thiamine-phosphate diphosphorylase activity
NWAT_RS05685	COG0028	Belongs to the TPP enzyme family
NWAT_RS05715	COG0577	efflux transmembrane transporter activity
NWAT_RS05725	COG0590	tRNA wobble adenosine to inosine editing
NWAT_RS05750	COG2111	Na H antiporter
NWAT_RS05750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NWAT_RS05755	COG0651	ATP synthesis coupled electron transport
NWAT_RS05780	COG1320	monovalent cation:proton antiporter activity
NWAT_RS05785	COG2212	antiporter activity
NWAT_RS05820	COG1403	HNH endonuclease
NWAT_RS05825	COG3012	SEC-C Motif Domain Protein
NWAT_RS05830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NWAT_RS05835	COG1643	Atp-dependent helicase
NWAT_RS05845	COG2183	response to ionizing radiation
NWAT_RS05855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NWAT_RS05860	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NWAT_RS05865	COG0450	alkyl hydroperoxide reductase
NWAT_RS05875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NWAT_RS05895	COG0308	aminopeptidase N
NWAT_RS05905	COG0028	Belongs to the TPP enzyme family
NWAT_RS05905	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
NWAT_RS05915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NWAT_RS05925	COG1657	PFAM Prenyltransferase squalene oxidase
NWAT_RS05945	COG0678	peroxiredoxin activity
NWAT_RS06010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NWAT_RS06015	COG2967	ApaG domain
NWAT_RS06020	COG0837	glucose binding
NWAT_RS06025	COG0363	glucosamine-6-phosphate deaminase activity
NWAT_RS06075	COG2983	Belongs to the UPF0260 family
NWAT_RS06100	COG1199	ATP-dependent helicase activity
NWAT_RS06130	COG2340	Cysteine-rich secretory protein family
NWAT_RS06135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NWAT_RS06150	COG0492	ferredoxin-NADP+ reductase activity
NWAT_RS06170	COG0628	permease
NWAT_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS06255	COG0714	Associated with various cellular activities
NWAT_RS06285	COG2239	Acts as a magnesium transporter
NWAT_RS06290	COG0483	inositol monophosphate 1-phosphatase activity
NWAT_RS06295	COG0583	DNA-binding transcription factor activity
NWAT_RS06300	COG1126	abc transporter atp-binding protein
NWAT_RS06305	COG0390	transport system, permease component
NWAT_RS06320	COG1704	LemA family
NWAT_RS06325	COG0501	Belongs to the peptidase M48B family
NWAT_RS06330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NWAT_RS06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NWAT_RS06385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NWAT_RS06400	COG4264	IucA IucC family
NWAT_RS06425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NWAT_RS06440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NWAT_RS06455	COG1902	pentaerythritol trinitrate reductase activity
NWAT_RS06460	COG1858	cytochrome C peroxidase
NWAT_RS06475	COG0753	catalase activity
NWAT_RS06485	COG0788	formyltetrahydrofolate deformylase activity
NWAT_RS06510	COG2239	Acts as a magnesium transporter
NWAT_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
NWAT_RS06530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NWAT_RS06555	COG1819	glycosyl
NWAT_RS06560	COG0842	Transport permease protein
NWAT_RS06565	COG0842	Transport permease protein
NWAT_RS06570	COG1131	(ABC) transporter
NWAT_RS06585	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NWAT_RS06620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NWAT_RS06625	COG1301	dicarboxylic acid transport
NWAT_RS06640	COG2010	Cytochrome c
NWAT_RS06640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NWAT_RS06645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NWAT_RS06685	COG0596	Alpha beta hydrolase
NWAT_RS06695	COG0745	RESPONSE REGULATOR receiver
NWAT_RS06700	COG5002	protein histidine kinase activity
NWAT_RS06705	COG0673	inositol 2-dehydrogenase activity
NWAT_RS06715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NWAT_RS06720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NWAT_RS06730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NWAT_RS06735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NWAT_RS06755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NWAT_RS06760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NWAT_RS06765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NWAT_RS06785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NWAT_RS06790	COG1032	radical SAM domain protein
NWAT_RS06800	COG2135	peptidase activity
NWAT_RS06810	COG0183	Belongs to the thiolase family
NWAT_RS06815	COG1250	3-hydroxyacyl-CoA dehydrogenase
NWAT_RS06815	COG1024	Enoyl-CoA hydratase
NWAT_RS06830	COG0033	Phosphoglucomutase
NWAT_RS06835	COG0424	maF-like protein
NWAT_RS06840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NWAT_RS06850	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NWAT_RS06855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NWAT_RS06860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NWAT_RS06880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NWAT_RS06885	COG1518	maintenance of DNA repeat elements
NWAT_RS06900	COG1857	crispr-associated protein
NWAT_RS06915	COG1203	CRISPR-associated helicase, Cas3
NWAT_RS06960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NWAT_RS06975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NWAT_RS06985	COG3360	Dodecin
NWAT_RS07000	COG0784	Response regulator, receiver
NWAT_RS07005	COG4251	negative regulation of phosphorylation
NWAT_RS07010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NWAT_RS07015	COG4566	intracellular signal transduction
NWAT_RS07035	COG1070	Carbohydrate kinase
NWAT_RS07040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NWAT_RS07045	COG1196	nuclear chromosome segregation
NWAT_RS07050	COG3115	cell septum assembly
NWAT_RS07055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NWAT_RS07060	COG0432	Pfam Uncharacterised protein family UPF0047
NWAT_RS07075	COG0488	(ABC) transporter
NWAT_RS07095	COG2855	membrane
NWAT_RS07120	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS07150	COG1104	cysteine desulfurase activity
NWAT_RS07155	COG0084	hydrolase, TatD family'
NWAT_RS07170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NWAT_RS07175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NWAT_RS07180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NWAT_RS07185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NWAT_RS07190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NWAT_RS07205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NWAT_RS07210	COG0416	fatty acid biosynthetic process
NWAT_RS07215	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NWAT_RS07230	COG1286	toxin biosynthetic process
NWAT_RS07240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NWAT_RS07245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NWAT_RS07250	COG0740	serine-type endopeptidase activity
NWAT_RS07255	COG0544	peptidyl-prolyl cis-trans isomerase activity
NWAT_RS07280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NWAT_RS07290	COG0316	Belongs to the HesB IscA family
NWAT_RS07295	COG1104	cysteine desulfurase activity
NWAT_RS07300	COG1959	2 iron, 2 sulfur cluster binding
NWAT_RS07315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NWAT_RS07325	COG0322	excinuclease ABC activity
NWAT_RS07330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NWAT_RS07345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NWAT_RS07380	COG1959	2 iron, 2 sulfur cluster binding
NWAT_RS07380	COG1295	ribonuclease BN
NWAT_RS07385	COG0330	HflC and HflK could
NWAT_RS07395	COG2104	thiamine diphosphate biosynthetic process
NWAT_RS07395	COG2022	thiamine diphosphate biosynthetic process
NWAT_RS07400	COG4566	intracellular signal transduction
NWAT_RS07415	COG0114	fumarate hydratase activity
NWAT_RS07420	COG0659	secondary active sulfate transmembrane transporter activity
NWAT_RS07430	COG3852	Histidine kinase
NWAT_RS07435	COG2204	response regulator
NWAT_RS07455	COG0215	cysteine-tRNA ligase activity
NWAT_RS07460	COG3387	PFAM Glycoside hydrolase 15-related
NWAT_RS07490	COG1858	cytochrome C peroxidase
NWAT_RS07515	COG2918	glutathione biosynthetic process
NWAT_RS07520	COG1881	PFAM PEBP family protein
NWAT_RS07535	COG0070	glutamate synthase
NWAT_RS07535	COG0069	glutamate synthase activity
NWAT_RS07535	COG0067	glutamate synthase
NWAT_RS07555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NWAT_RS07560	COG0037	tRNA processing
NWAT_RS07570	COG1295	ribonuclease BN
NWAT_RS07610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NWAT_RS07620	COG0493	'glutamate synthase
NWAT_RS07620	COG0543	2 iron, 2 sulfur cluster binding
NWAT_RS07655	COG0281	malic enzyme
NWAT_RS07655	COG0280	phosphate acetyltransferase
NWAT_RS07670	COG5433	transposase activity
NWAT_RS07675	COG1620	l-lactate permease
NWAT_RS07710	COG0071	Belongs to the small heat shock protein (HSP20) family
NWAT_RS07725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NWAT_RS07730	COG5285	phytanoyl-CoA dioxygenase
NWAT_RS07735	COG0477	Major facilitator Superfamily
NWAT_RS07740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NWAT_RS07750	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS07760	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NWAT_RS07790	COG0189	ligase activity
NWAT_RS07790	COG4067	protein conserved in archaea
NWAT_RS07795	COG0189	ligase activity
NWAT_RS07810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NWAT_RS07815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NWAT_RS07825	COG2340	Cysteine-rich secretory protein family
NWAT_RS07840	COG2132	Multicopper oxidase
NWAT_RS07875	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NWAT_RS07885	COG3218	ABC-type transport auxiliary lipoprotein component
NWAT_RS07885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NWAT_RS07890	COG1127	ABC transporter
NWAT_RS07895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NWAT_RS07905	COG2217	Heavy metal translocating P-type atpase
NWAT_RS07925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NWAT_RS07950	COG0297	glycogen (starch) synthase activity
NWAT_RS07970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NWAT_RS08000	COG2151	metal-sulfur cluster biosynthetic enzyme
NWAT_RS08055	COG0435	Glutathione S-transferase
NWAT_RS08065	COG0583	DNA-binding transcription factor activity
NWAT_RS08090	COG0823	Involved in the tonB-independent uptake of proteins
NWAT_RS08100	COG2807	transmembrane transport
NWAT_RS08125	COG0574	Belongs to the PEP-utilizing enzyme family
NWAT_RS08125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NWAT_RS08150	COG0628	permease
NWAT_RS08205	COG0598	Magnesium transport protein CorA
NWAT_RS08255	COG0588	phosphoglycerate mutase activity
NWAT_RS08260	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NWAT_RS08280	COG0302	gtp cyclohydrolase
NWAT_RS08285	COG0121	glutamine amidotransferase
NWAT_RS08295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NWAT_RS08320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NWAT_RS08330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NWAT_RS08350	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NWAT_RS08365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NWAT_RS08375	COG1193	negative regulation of DNA recombination
NWAT_RS08380	COG0047	phosphoribosylformylglycinamidine synthase activity
NWAT_RS08380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NWAT_RS08390	COG0795	lipopolysaccharide-transporting ATPase activity
NWAT_RS08395	COG0795	lipopolysaccharide-transporting ATPase activity
NWAT_RS08405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NWAT_RS08430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NWAT_RS08455	COG0277	FAD linked oxidase domain protein
NWAT_RS08455	COG0247	lactate metabolic process
NWAT_RS08480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NWAT_RS08485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NWAT_RS08490	COG0742	ribosomal rna small subunit methyltransferase
NWAT_RS08500	COG0612	Peptidase, M16
NWAT_RS08505	COG0552	protein localization to endoplasmic reticulum
NWAT_RS08585	COG0318	PFAM AMP-dependent synthetase and ligase
NWAT_RS08610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NWAT_RS08660	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NWAT_RS08665	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS08670	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS08680	COG0367	asparagine synthase
NWAT_RS08690	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS08790	COG2204	response regulator
NWAT_RS08795	COG2205	protein histidine kinase activity
NWAT_RS08800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NWAT_RS08815	COG0129	dihydroxy-acid dehydratase activity
NWAT_RS08820	COG0210	DNA helicase
NWAT_RS08825	COG0606	chelatase, subunit chli
NWAT_RS08865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NWAT_RS08885	COG1690	Belongs to the RtcB family
NWAT_RS08890	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NWAT_RS08905	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NWAT_RS08915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NWAT_RS08925	COG2867	negative regulation of translational initiation
NWAT_RS08930	COG2914	Belongs to the UPF0125 (RnfH) family
NWAT_RS08940	COG0735	belongs to the Fur family
NWAT_RS08955	COG0497	DNA recombination
NWAT_RS08960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NWAT_RS08965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NWAT_RS08975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NWAT_RS08980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NWAT_RS08990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NWAT_RS08995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NWAT_RS09000	COG0717	Belongs to the dCTP deaminase family
NWAT_RS09005	COG1862	Preprotein translocase
NWAT_RS09030	COG3273	potassium ion transport
NWAT_RS09030	COG0471	metal ion transport
NWAT_RS09045	COG2878	Part of a membrane complex involved in electron transport
NWAT_RS09065	COG4660	Part of a membrane complex involved in electron transport
NWAT_RS09070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NWAT_RS09080	COG2205	protein histidine kinase activity
NWAT_RS09080	COG0784	Response regulator, receiver
NWAT_RS09085	COG0590	tRNA wobble adenosine to inosine editing
NWAT_RS09090	COG0753	catalase activity
NWAT_RS09160	COG0776	regulation of translation
NWAT_RS09165	COG0072	phenylalanine-tRNA ligase activity
NWAT_RS09170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NWAT_RS09175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NWAT_RS09180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NWAT_RS09185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NWAT_RS09190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NWAT_RS09200	COG0556	nucleotide-excision repair
NWAT_RS09205	COG0436	Aminotransferase
NWAT_RS09230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NWAT_RS09260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NWAT_RS09315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS09320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS09325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS09325	COG0649	NAD binding
NWAT_RS09345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NWAT_RS09350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS09360	COG0713	ATP synthesis coupled electron transport
NWAT_RS09375	COG1007	ATP synthesis coupled electron transport
NWAT_RS09385	COG2832	Protein of unknown function (DUF454)
NWAT_RS09480	COG0525	valine-tRNA ligase activity
NWAT_RS09505	COG1047	Peptidyl-prolyl cis-trans
NWAT_RS09510	COG1573	uracil-dna glycosylase
NWAT_RS09515	COG0189	ligase activity
NWAT_RS09525	COG4067	protein conserved in archaea
NWAT_RS09525	COG0189	ligase activity
NWAT_RS09570	COG1295	ribonuclease BN
NWAT_RS09635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
NWAT_RS09640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NWAT_RS09655	COG0742	ribosomal rna small subunit methyltransferase
NWAT_RS09665	COG1324	tolerance protein
NWAT_RS09670	COG4232	protein-disulfide reductase activity
NWAT_RS09675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NWAT_RS09680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NWAT_RS09685	COG0511	ligase activity, forming carbon-carbon bonds
NWAT_RS09690	COG0439	Biotin carboxylase
NWAT_RS09695	COG2264	protein methyltransferase activity
NWAT_RS09700	COG3387	PFAM Glycoside hydrolase 15-related
NWAT_RS09705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NWAT_RS09710	COG0138	bifunctional purine biosynthesis protein purh
NWAT_RS09715	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NWAT_RS09730	COG0316	Belongs to the HesB IscA family
NWAT_RS09740	COG1562	ergosterol biosynthetic process
NWAT_RS09750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NWAT_RS09755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NWAT_RS09760	COG0180	Tryptophanyl-tRNA synthetase
NWAT_RS09765	COG1994	Peptidase M50
NWAT_RS09770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NWAT_RS09800	COG0527	aspartate kinase activity
NWAT_RS09805	COG1917	Cupin 2, conserved barrel domain protein
NWAT_RS09815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NWAT_RS09830	COG0285	dihydrofolate synthase activity
NWAT_RS09835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NWAT_RS09840	COG0159	tryptophan synthase activity
NWAT_RS09845	COG0133	tryptophan synthase activity
NWAT_RS09850	COG0135	phosphoribosylanthranilate isomerase activity
NWAT_RS09855	COG0101	tRNA pseudouridine synthase activity
NWAT_RS09875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NWAT_RS09885	COG0473	3-isopropylmalate dehydrogenase activity
NWAT_RS09890	COG0066	3-isopropylmalate dehydratase activity
NWAT_RS09905	COG1994	Peptidase M50
NWAT_RS09905	COG0517	IMP dehydrogenase activity
NWAT_RS09910	COG2270	Major facilitator Superfamily
NWAT_RS09935	COG1358	cellular component organization or biogenesis
NWAT_RS09965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NWAT_RS09975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NWAT_RS09985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NWAT_RS09990	COG2226	methyltransferase
NWAT_RS10005	COG0596	Alpha beta hydrolase
NWAT_RS10040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NWAT_RS10040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NWAT_RS10055	COG0644	oxidoreductase
NWAT_RS10110	COG0489	protein tyrosine kinase activity
NWAT_RS10115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NWAT_RS10115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NWAT_RS10120	COG4657	Part of a membrane complex involved in electron transport
NWAT_RS10135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NWAT_RS10140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NWAT_RS10155	COG1615	UPF0182 protein
NWAT_RS10160	COG0475	glutathione-regulated potassium exporter activity
NWAT_RS10170	COG1561	YicC-like family, N-terminal region
NWAT_RS10195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NWAT_RS10200	COG0215	cysteine-tRNA ligase activity
NWAT_RS10205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NWAT_RS10215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NWAT_RS10225	COG1666	GTP binding
NWAT_RS10240	COG0335	large ribosomal subunit rRNA binding
NWAT_RS10245	COG0336	Belongs to the RNA methyltransferase TrmD family
NWAT_RS10250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NWAT_RS10255	COG0228	four-way junction DNA binding
NWAT_RS10260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NWAT_RS10270	COG4536	flavin adenine dinucleotide binding
NWAT_RS10290	COG1194	a g-specific adenine glycosylase
NWAT_RS10295	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NWAT_RS10335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NWAT_RS10340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NWAT_RS10350	COG1489	DNA binding
NWAT_RS10355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NWAT_RS10375	COG1993	acr, cog1993
NWAT_RS10380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NWAT_RS10405	COG0175	sulfate reduction
NWAT_RS10410	COG0175	sulfate reduction
NWAT_RS10415	COG0730	response to heat
NWAT_RS10425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NWAT_RS10435	COG0402	S-adenosylhomocysteine deaminase activity
NWAT_RS10440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NWAT_RS10450	COG0203	ribosomal protein L17
NWAT_RS10455	COG0202	RNA polymerase activity
NWAT_RS10460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NWAT_RS10465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NWAT_RS10470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NWAT_RS10475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NWAT_RS10480	COG0201	protein transport
NWAT_RS10485	COG0200	Binds to the 23S rRNA
NWAT_RS10490	COG1841	ribosomal large subunit assembly
NWAT_RS10495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NWAT_RS10500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NWAT_RS10505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NWAT_RS10510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NWAT_RS10515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NWAT_RS10520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NWAT_RS10525	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NWAT_RS10530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NWAT_RS10535	COG0255	Belongs to the universal ribosomal protein uL29 family
NWAT_RS10540	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NWAT_RS10545	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NWAT_RS10550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NWAT_RS10555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NWAT_RS10560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NWAT_RS10565	COG0089	rRNA binding
NWAT_RS10570	COG0088	Forms part of the polypeptide exit tunnel
NWAT_RS10575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NWAT_RS10580	COG0051	transcription antitermination factor activity, RNA binding
NWAT_RS10585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NWAT_RS10590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NWAT_RS10595	COG0049	tRNA binding
NWAT_RS10600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NWAT_RS10605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NWAT_RS10610	COG0085	RNA polymerase activity
NWAT_RS10615	COG0222	ribosome binding
NWAT_RS10620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NWAT_RS10625	COG0081	regulation of translation
NWAT_RS10630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NWAT_RS10640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NWAT_RS10650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NWAT_RS10655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NWAT_RS10660	COG0049	tRNA binding
NWAT_RS10665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NWAT_RS10670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NWAT_RS10675	COG0085	RNA polymerase activity
NWAT_RS10680	COG0222	ribosome binding
NWAT_RS10685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NWAT_RS10690	COG0081	regulation of translation
NWAT_RS10695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NWAT_RS10705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NWAT_RS10715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NWAT_RS10740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NWAT_RS10745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NWAT_RS10765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NWAT_RS10775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NWAT_RS10785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NWAT_RS10790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NWAT_RS10795	COG1862	Preprotein translocase
NWAT_RS10800	COG0343	queuine tRNA-ribosyltransferase activity
NWAT_RS10805	COG0284	orotidine-5'-phosphate decarboxylase activity
NWAT_RS10840	COG1677	Flagellar hook-basal body complex protein FliE
NWAT_RS10870	COG1334	flagellar protein FlaG
NWAT_RS10885	COG1256	bacterial-type flagellum assembly
NWAT_RS10890	COG3951	Flagellar rod assembly protein muramidase FlgJ
NWAT_RS10890	COG1705	Flagellar rod assembly protein muramidase FlgJ
NWAT_RS10895	COG1706	bacterial-type flagellum-dependent cell motility
NWAT_RS10900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NWAT_RS10905	COG4786	Flagellar basal body rod
NWAT_RS10915	COG4786	Flagellar basal body rod
NWAT_RS10925	COG1558	bacterial-type flagellum-dependent cell motility
NWAT_RS10930	COG1815	bacterial-type flagellum-dependent cell motility
NWAT_RS10945	COG0542	response to heat
NWAT_RS10955	COG0009	L-threonylcarbamoyladenylate synthase
NWAT_RS10960	COG0613	PHP domain protein
NWAT_RS10965	COG2917	probably involved in intracellular septation
NWAT_RS10970	COG2350	Protein conserved in bacteria
NWAT_RS11000	COG2096	Adenosyltransferase
NWAT_RS11005	COG3023	N-Acetylmuramoyl-L-alanine amidase
NWAT_RS11015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NWAT_RS11020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NWAT_RS11020	COG1648	precorrin-2 dehydrogenase activity
NWAT_RS11030	COG4771	TonB-dependent receptor
NWAT_RS11045	COG0585	pseudouridine synthase activity
NWAT_RS11050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NWAT_RS11055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NWAT_RS11060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NWAT_RS11065	COG0148	phosphopyruvate hydratase activity
NWAT_RS11070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NWAT_RS11075	COG0504	CTP synthase activity
NWAT_RS11080	COG0037	tRNA processing
NWAT_RS11085	COG0825	malonyl-CoA metabolic process
NWAT_RS11090	COG5001	Diguanylate cyclase
NWAT_RS11090	COG3706	GGDEF domain
NWAT_RS11090	COG2203	Gaf domain
NWAT_RS11090	COG4251	negative regulation of phosphorylation
NWAT_RS11105	COG0277	FAD linked oxidase domain protein
NWAT_RS11110	COG0616	signal peptide processing
NWAT_RS11120	COG0247	lactate metabolic process
NWAT_RS11125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NWAT_RS11130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NWAT_RS11135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NWAT_RS11165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NWAT_RS11180	COG0366	Alpha amylase catalytic
NWAT_RS11185	COG0366	Alpha amylase catalytic
NWAT_RS11200	COG1024	Enoyl-CoA hydratase
NWAT_RS11200	COG1250	3-hydroxyacyl-CoA dehydrogenase
NWAT_RS11220	COG1160	GTP binding
NWAT_RS11230	COG2976	Protein conserved in bacteria
NWAT_RS11235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NWAT_RS11240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NWAT_RS11250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NWAT_RS11260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NWAT_RS11270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NWAT_RS11275	COG0233	cytoplasmic translational termination
NWAT_RS11280	COG0528	UMP kinase activity
NWAT_RS11285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NWAT_RS11290	COG0052	Belongs to the universal ribosomal protein uS2 family
NWAT_RS11295	COG0024	Methionine aminopeptidase
NWAT_RS11300	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NWAT_RS11305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NWAT_RS11310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NWAT_RS11315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NWAT_RS11325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NWAT_RS11350	COG0736	holo-[acyl-carrier-protein] synthase activity
NWAT_RS11355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NWAT_RS11360	COG1381	Involved in DNA repair and RecF pathway recombination
NWAT_RS11380	COG1238	metal cluster binding
NWAT_RS11385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NWAT_RS11390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NWAT_RS11395	COG2204	response regulator
NWAT_RS11405	COG2205	protein histidine kinase activity
NWAT_RS11430	COG0540	Belongs to the ATCase OTCase family
NWAT_RS11435	COG0367	asparagine synthase
NWAT_RS11455	COG1088	dTDP-glucose 4,6-dehydratase activity
NWAT_RS11460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NWAT_RS11465	COG0297	glycogen (starch) synthase activity
NWAT_RS11470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NWAT_RS11520	COG1450	Type ii and iii secretion system protein
NWAT_RS11540	COG3156	type II secretion system protein K
NWAT_RS11575	COG0463	Glycosyl transferase, family 2
NWAT_RS11585	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS11630	COG3119	arylsulfatase activity
NWAT_RS11640	COG3551	Protein conserved in bacteria
NWAT_RS11725	COG1217	gtp-binding protein TYPA
NWAT_RS11740	COG1376	ErfK ybiS ycfS ynhG family protein
NWAT_RS11755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NWAT_RS11760	COG0045	succinate-CoA ligase (ADP-forming) activity
NWAT_RS11770	COG1490	D-aminoacyl-tRNA deacylase activity
NWAT_RS11780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NWAT_RS11795	COG0419	ATPase involved in DNA repair
NWAT_RS11800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NWAT_RS11830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NWAT_RS11860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NWAT_RS11925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NWAT_RS11975	COG4691	Plasmid stability protein
NWAT_RS12010	COG4974	Belongs to the 'phage' integrase family
NWAT_RS12015	COG1475	DNA binding
NWAT_RS12085	COG2814	Major facilitator Superfamily
NWAT_RS12090	COG0402	S-adenosylhomocysteine deaminase activity
NWAT_RS12105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NWAT_RS12105	COG0519	Catalyzes the synthesis of GMP from XMP
NWAT_RS12110	COG0516	GMP reductase activity
NWAT_RS12110	COG0517	IMP dehydrogenase activity
NWAT_RS12115	COG1570	exodeoxyribonuclease VII activity
NWAT_RS12130	COG0848	biopolymer transport protein
NWAT_RS12135	COG0811	peptide transport
NWAT_RS12140	COG0811	peptide transport
NWAT_RS12150	COG1773	rubredoxin
NWAT_RS12155	COG0352	thiamine-phosphate diphosphorylase activity
NWAT_RS12165	COG0668	transmembrane transport
NWAT_RS12175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NWAT_RS12180	COG0210	DNA helicase
NWAT_RS12185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
NWAT_RS12200	COG1230	cation diffusion facilitator family transporter
NWAT_RS12215	COG4067	protein conserved in archaea
NWAT_RS12215	COG0189	ligase activity
NWAT_RS12225	COG0859	PFAM glycosyl transferase family 9
NWAT_RS12230	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS12250	COG0500	methyltransferase
NWAT_RS12270	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NWAT_RS12295	COG0419	ATPase involved in DNA repair
NWAT_RS12300	COG0420	3'-5' exonuclease activity
NWAT_RS12340	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS12345	COG0367	asparagine synthase
NWAT_RS12370	COG0463	Glycosyl transferase, family 2
NWAT_RS12385	COG3609	addiction module antidote protein, CC2985 family
NWAT_RS12400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NWAT_RS12405	COG1943	Transposase
NWAT_RS12420	COG1174	glycine betaine transport
NWAT_RS12425	COG1125	glycine betaine transport
NWAT_RS12425	COG0517	IMP dehydrogenase activity
NWAT_RS12435	COG2204	response regulator
NWAT_RS12480	COG2337	Toxic component of a toxin-antitoxin (TA) module
NWAT_RS12500	COG1598	PFAM Uncharacterised protein family UPF0150
NWAT_RS12515	COG1598	PFAM Uncharacterised protein family UPF0150
NWAT_RS12530	COG3119	arylsulfatase activity
NWAT_RS12535	COG3119	arylsulfatase activity
NWAT_RS12535	COG3119	arylsulfatase activity
NWAT_RS12540	COG3119	arylsulfatase activity
NWAT_RS12550	COG0012	GTP binding
NWAT_RS12555	COG0193	aminoacyl-tRNA hydrolase activity
NWAT_RS12560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NWAT_RS12565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NWAT_RS12575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NWAT_RS12580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NWAT_RS12590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NWAT_RS12595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NWAT_RS12600	COG0850	regulation of cytokinetic process
NWAT_RS12605	COG2894	cell division
NWAT_RS12610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NWAT_RS12640	COG0165	Argininosuccinate lyase
NWAT_RS12645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NWAT_RS12705	COG0277	FAD linked oxidase domain protein
NWAT_RS12735	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NWAT_RS12745	COG1652	LysM domain
NWAT_RS12800	COG1007	ATP synthesis coupled electron transport
NWAT_RS12820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NWAT_RS12835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NWAT_RS12840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NWAT_RS12850	COG1028	Short-chain dehydrogenase reductase Sdr
NWAT_RS12855	COG0028	Belongs to the TPP enzyme family
NWAT_RS12860	COG4948	Mandelate Racemase Muconate Lactonizing
NWAT_RS12925	COG4572	Cation transport regulator
NWAT_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
NWAT_RS12950	COG0037	tRNA processing
NWAT_RS12950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NWAT_RS12955	COG1752	Esterase of the alpha-beta hydrolase superfamily
NWAT_RS13005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NWAT_RS13010	COG1129	ABC transporter
NWAT_RS13010	COG0842	Transport permease protein
NWAT_RS13015	COG0842	Transport permease protein
NWAT_RS13030	COG4181	ATPase activity
NWAT_RS13035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NWAT_RS13050	COG3228	Belongs to the MtfA family
NWAT_RS13090	COG3093	addiction module antidote protein HigA
NWAT_RS13110	COG2801	Transposase and inactivated derivatives
NWAT_RS13145	COG3093	addiction module antidote protein HigA
NWAT_RS13220	COG2890	protein-(glutamine-N5) methyltransferase activity
NWAT_RS13230	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS13240	COG0617	tRNA 3'-terminal CCA addition
NWAT_RS13255	COG0501	Belongs to the peptidase M48B family
NWAT_RS13270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NWAT_RS13275	COG0751	glycine-tRNA ligase activity
NWAT_RS13290	COG0729	surface antigen
NWAT_RS13300	COG1678	Uncharacterized ACR, COG1678
NWAT_RS13305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NWAT_RS13310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NWAT_RS13315	COG0540	Belongs to the ATCase OTCase family
NWAT_RS13325	COG0543	2 iron, 2 sulfur cluster binding
NWAT_RS13330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NWAT_RS13360	COG3107	peptidoglycan biosynthetic process
NWAT_RS13365	COG0792	nuclease activity
NWAT_RS13370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NWAT_RS13375	COG2823	Periplasmic or secreted lipoprotein
NWAT_RS13380	COG0277	FAD linked oxidase domain protein
NWAT_RS13400	COG1674	ftsk spoiiie
NWAT_RS13405	COG0686	Belongs to the AlaDH PNT family
NWAT_RS13410	COG0492	ferredoxin-NADP+ reductase activity
NWAT_RS13415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NWAT_RS13435	COG0501	Belongs to the peptidase M48B family
NWAT_RS13440	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NWAT_RS13450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NWAT_RS13450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NWAT_RS13455	COG0802	atpase or kinase
NWAT_RS13460	COG0860	N-Acetylmuramoyl-L-alanine amidase
NWAT_RS13465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NWAT_RS13470	COG5001	Diguanylate cyclase
NWAT_RS13470	COG5002	protein histidine kinase activity
NWAT_RS13480	COG1850	ribulose-bisphosphate carboxylase activity
NWAT_RS13485	COG4451	ribulose bisphosphate carboxylase, small
NWAT_RS13540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NWAT_RS13565	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NWAT_RS13590	COG1444	tRNA N-acetyltransferase activity
NWAT_RS13595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NWAT_RS13615	COG1115	amino acid carrier protein
NWAT_RS13640	COG2873	o-acetylhomoserine
NWAT_RS13645	COG2321	neutral zinc metallopeptidase
NWAT_RS13650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NWAT_RS13655	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NWAT_RS13660	COG3100	YcgL domain-containing protein
NWAT_RS13660	COG0561	phosphatase activity
NWAT_RS13665	COG1295	ribonuclease BN
NWAT_RS13670	COG2995	paraquat-inducible protein a
NWAT_RS13675	COG3008	intermembrane lipid transfer
NWAT_RS13675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NWAT_RS13690	COG1477	protein flavinylation
NWAT_RS13695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NWAT_RS13710	COG3119	arylsulfatase activity
NWAT_RS13725	COG0488	(ABC) transporter
NWAT_RS13730	COG0071	Belongs to the small heat shock protein (HSP20) family
NWAT_RS13765	COG1215	transferase activity, transferring glycosyl groups
NWAT_RS13770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NWAT_RS13820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NWAT_RS13825	COG2244	polysaccharide biosynthetic process
NWAT_RS13835	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS13850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NWAT_RS13855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NWAT_RS13960	COG4115	mRNA cleavage
NWAT_RS13965	COG2161	toxin-antitoxin pair type II binding
NWAT_RS13970	COG4115	mRNA cleavage
NWAT_RS13975	COG1278	Cold shock
NWAT_RS14020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NWAT_RS14035	COG1981	membrane
NWAT_RS14050	COG5001	Diguanylate cyclase
NWAT_RS14050	COG5002	protein histidine kinase activity
NWAT_RS14060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NWAT_RS14070	COG0359	binds to the 23S rRNA
NWAT_RS14075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NWAT_RS14080	COG0360	Binds together with S18 to 16S ribosomal RNA
NWAT_RS14085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NWAT_RS14095	COG1515	deoxyribonuclease V activity
NWAT_RS14120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NWAT_RS14130	COG0708	Exodeoxyribonuclease III
NWAT_RS14135	COG0339	signal peptide processing
NWAT_RS14140	COG2208	phosphoserine phosphatase activity
NWAT_RS14150	COG2217	Heavy metal translocating P-type atpase
NWAT_RS14170	COG0459	protein refolding
NWAT_RS14175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NWAT_RS14205	COG2226	methyltransferase
NWAT_RS14240	COG2890	protein-(glutamine-N5) methyltransferase activity
NWAT_RS14245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NWAT_RS14265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NWAT_RS14325	COG4680	protein conserved in bacteria
NWAT_RS14340	COG1132	(ABC) transporter
NWAT_RS14345	COG0589	response to stress
NWAT_RS14365	COG1742	UPF0060 membrane protein
NWAT_RS14430	COG0297	glycogen (starch) synthase activity
NWAT_RS14440	COG2165	general secretion pathway protein
NWAT_RS14445	COG4970	Tfp pilus assembly protein FimT
NWAT_RS14450	COG2165	general secretion pathway protein
NWAT_RS14455	COG1459	type II secretion system
NWAT_RS14460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NWAT_RS14465	COG0688	phosphatidylethanolamine metabolic process
NWAT_RS14470	COG2132	Multicopper oxidase
NWAT_RS14475	COG0557	exoribonuclease II activity
NWAT_RS14490	COG1999	signal sequence binding
NWAT_RS14530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NWAT_RS14555	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS14575	COG5433	transposase activity
NWAT_RS14585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NWAT_RS14590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NWAT_RS14595	COG1309	transcriptional regulator
NWAT_RS14605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NWAT_RS14635	COG0776	regulation of translation
NWAT_RS14640	COG1959	2 iron, 2 sulfur cluster binding
NWAT_RS14655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NWAT_RS14670	COG1730	sister chromatid segregation
NWAT_RS14685	COG3854	ATPases associated with a variety of cellular activities
NWAT_RS14690	COG1366	Belongs to the anti-sigma-factor antagonist family
NWAT_RS14700	COG2902	Dehydrogenase
NWAT_RS14705	COG3920	Histidine kinase
NWAT_RS14705	COG2202	Pas domain
NWAT_RS14715	COG1260	myo-inositol-1-phosphate synthase
NWAT_RS14720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NWAT_RS14740	COG1366	Belongs to the anti-sigma-factor antagonist family
NWAT_RS14750	COG1388	LysM domain
NWAT_RS14750	COG3584	3D domain protein
NWAT_RS14755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NWAT_RS14770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NWAT_RS14775	COG0756	dUTP diphosphatase activity
NWAT_RS14785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NWAT_RS14800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NWAT_RS14805	COG2223	nitrite transmembrane transporter activity
NWAT_RS14810	COG1872	DUF167
NWAT_RS14875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NWAT_RS14880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NWAT_RS14890	COG2922	Belongs to the Smg family
NWAT_RS14895	COG0758	DNA mediated transformation
NWAT_RS14905	COG0242	peptide deformylase activity
NWAT_RS14910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NWAT_RS14925	COG5000	phosphorelay sensor kinase activity
NWAT_RS14930	COG2204	response regulator
NWAT_RS14935	COG0569	domain protein
NWAT_RS14950	COG2814	Major facilitator Superfamily
NWAT_RS14955	COG0629	single-stranded DNA binding
NWAT_RS14970	COG0142	geranyltranstransferase activity
NWAT_RS14975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NWAT_RS14980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NWAT_RS14985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NWAT_RS14990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NWAT_RS14995	COG0268	Binds directly to 16S ribosomal RNA
NWAT_RS15000	COG0728	peptidoglycan biosynthetic process
NWAT_RS15005	COG0109	protoheme IX farnesyltransferase activity
NWAT_RS15010	COG1612	heme a metabolic process
NWAT_RS15035	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
NWAT_RS15045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NWAT_RS15045	COG1565	acr, cog1565
NWAT_RS15070	COG0131	Imidazoleglycerol-phosphate dehydratase
NWAT_RS15075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NWAT_RS15080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NWAT_RS15085	COG0107	imidazoleglycerol-phosphate synthase activity
NWAT_RS15090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NWAT_RS15095	COG0140	phosphoribosyl-ATP diphosphatase activity
NWAT_RS15105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NWAT_RS15110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NWAT_RS15115	COG0805	protein transport
NWAT_RS15130	COG0531	amino acid
NWAT_RS15135	COG4651	solute:proton antiporter activity
NWAT_RS15135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NWAT_RS15165	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS15170	COG0438	transferase activity, transferring glycosyl groups
NWAT_RS15175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NWAT_RS15185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NWAT_RS15190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NWAT_RS15195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NWAT_RS15200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NWAT_RS15205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NWAT_RS15210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NWAT_RS15215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NWAT_RS15220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NWAT_RS15225	COG0356	it plays a direct role in the translocation of protons across the membrane
NWAT_RS15235	COG1475	DNA binding
NWAT_RS15240	COG1192	Involved in chromosome partitioning
NWAT_RS15245	COG0357	Ribosomal RNA small subunit methyltransferase G
NWAT_RS15250	COG0445	tRNA wobble uridine modification
NWAT_RS15255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NWAT_RS15260	COG0706	membrane insertase activity
NWAT_RS15265	COG0594	ribonuclease P activity
NWAT_RS15295	COG0592	DNA-directed DNA polymerase activity
NWAT_RS15495	COG0592	DNA-directed DNA polymerase activity
NWAT_RS15590	COG1404	Belongs to the peptidase S8 family
NWAT_RS15595	COG2197	response regulator
NWAT_RS15605	COG3551	Protein conserved in bacteria
NWAT_RS15625	COG0732	type I restriction modification DNA specificity domain
NWAT_RS15645	COG1203	CRISPR-associated helicase, Cas3
NWAT_RS15680	COG1196	nuclear chromosome segregation
NWAT_RS15705	COG0732	type I restriction modification DNA specificity domain
NWAT_RS15725	COG1012	belongs to the aldehyde dehydrogenase family
NWAT_RS15760	COG3267	Type II secretory pathway component ExeA
NWAT_RS15760	COG3409	Peptidoglycan-binding domain 1 protein