locus-tag	class	description
DSM104443_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM104443_RS00010	COG0592	DNA-directed DNA polymerase activity
DSM104443_RS00040	COG0758	DNA mediated transformation
DSM104443_RS00050	COG0242	peptide deformylase activity
DSM104443_RS00055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104443_RS00065	COG5000	phosphorelay sensor kinase activity
DSM104443_RS00070	COG2204	response regulator
DSM104443_RS00085	COG4608	Belongs to the ABC transporter superfamily
DSM104443_RS00090	COG0444	Belongs to the ABC transporter superfamily
DSM104443_RS00100	COG0601	transmembrane transport
DSM104443_RS00105	COG0747	negative chemotaxis
DSM104443_RS00115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSM104443_RS00165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSM104443_RS00180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSM104443_RS00185	COG0352	thiamine-phosphate diphosphorylase activity
DSM104443_RS00190	COG0351	phosphomethylpyrimidine kinase
DSM104443_RS00195	COG1773	rubredoxin
DSM104443_RS00215	COG0840	transmembrane signaling receptor activity
DSM104443_RS00220	COG2198	Histidine kinase
DSM104443_RS00220	COG0784	Response regulator, receiver
DSM104443_RS00220	COG0643	Histidine kinase
DSM104443_RS00235	COG1968	undecaprenyl-diphosphatase activity
DSM104443_RS00250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DSM104443_RS00265	COG1131	(ABC) transporter
DSM104443_RS00270	COG0842	Transport permease protein
DSM104443_RS00275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104443_RS00280	COG1538	Outer membrane efflux protein
DSM104443_RS00340	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DSM104443_RS00350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DSM104443_RS00355	COG1137	ATPase activity
DSM104443_RS00360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DSM104443_RS00365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSM104443_RS00375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DSM104443_RS00380	COG1660	Displays ATPase and GTPase activities
DSM104443_RS00405	COG3275	phosphorelay sensor kinase activity
DSM104443_RS00410	COG3279	Response regulator of the LytR AlgR family
DSM104443_RS00420	COG2022	thiamine diphosphate biosynthetic process
DSM104443_RS00430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM104443_RS00440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104443_RS00445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSM104443_RS00450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSM104443_RS00455	COG0631	protein serine/threonine phosphatase activity
DSM104443_RS00460	COG2815	serine threonine protein kinase
DSM104443_RS00460	COG0515	serine threonine protein kinase
DSM104443_RS00465	COG1561	YicC-like family, N-terminal region
DSM104443_RS00470	COG0194	GDP metabolic process
DSM104443_RS00475	COG1758	RNA polymerase activity
DSM104443_RS00480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104443_RS00490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM104443_RS00495	COG3161	chorismate lyase activity
DSM104443_RS00500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM104443_RS00510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104443_RS00510	COG0475	glutathione-regulated potassium exporter activity
DSM104443_RS00540	COG1131	(ABC) transporter
DSM104443_RS00545	COG0659	secondary active sulfate transmembrane transporter activity
DSM104443_RS00565	COG0783	Belongs to the Dps family
DSM104443_RS00570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104443_RS00595	COG0762	integral membrane protein
DSM104443_RS00615	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS00620	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS00635	COG0183	Belongs to the thiolase family
DSM104443_RS00640	COG1024	Enoyl-CoA hydratase
DSM104443_RS00640	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104443_RS00650	COG1129	ABC transporter
DSM104443_RS00670	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS00675	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS00685	COG2045	Belongs to the ComB family
DSM104443_RS00690	COG1063	alcohol dehydrogenase
DSM104443_RS00695	COG1414	Transcriptional regulator
DSM104443_RS00710	COG1530	ribonuclease E activity
DSM104443_RS00715	COG0424	maF-like protein
DSM104443_RS00720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DSM104443_RS00725	COG0799	negative regulation of ribosome biogenesis
DSM104443_RS00730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM104443_RS00735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM104443_RS00750	COG0495	leucyl-tRNA aminoacylation
DSM104443_RS00765	COG0210	DNA helicase
DSM104443_RS00775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DSM104443_RS00785	COG1611	Belongs to the LOG family
DSM104443_RS00790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104443_RS00790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSM104443_RS00800	COG0009	L-threonylcarbamoyladenylate synthase
DSM104443_RS00865	COG2815	serine threonine protein kinase
DSM104443_RS00865	COG0515	serine threonine protein kinase
DSM104443_RS00885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104443_RS00915	COG0138	bifunctional purine biosynthesis protein purh
DSM104443_RS00920	COG0151	Belongs to the GarS family
DSM104443_RS00935	COG0408	coproporphyrinogen oxidase activity
DSM104443_RS00965	COG0515	serine threonine protein kinase
DSM104443_RS00965	COG2815	serine threonine protein kinase
DSM104443_RS01010	COG4654	Cytochrome c, class I
DSM104443_RS01015	COG1331	Highly conserved protein containing a thioredoxin domain
DSM104443_RS01030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104443_RS01060	COG2814	Major facilitator Superfamily
DSM104443_RS01080	COG0667	Aldo Keto reductase
DSM104443_RS01115	COG0129	dihydroxy-acid dehydratase activity
DSM104443_RS01125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSM104443_RS01130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104443_RS01175	COG2197	response regulator
DSM104443_RS01225	COG3237	CsbD-like
DSM104443_RS01230	COG0628	permease
DSM104443_RS01240	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS01245	COG2205	protein histidine kinase activity
DSM104443_RS01265	COG0626	cystathionine gamma-synthase activity
DSM104443_RS01270	COG3001	Fructosamine kinase
DSM104443_RS01410	COG3813	Protein conserved in bacteria
DSM104443_RS01555	COG5285	phytanoyl-CoA dioxygenase
DSM104443_RS01675	COG1120	ATPase activity
DSM104443_RS01690	COG2205	protein histidine kinase activity
DSM104443_RS01700	COG4771	TonB-dependent receptor
DSM104443_RS01705	COG1305	Transglutaminase-like
DSM104443_RS01720	COG0437	4 iron, 4 sulfur cluster binding
DSM104443_RS01725	COG2864	formate dehydrogenase
DSM104443_RS01740	COG0509	glycine decarboxylation via glycine cleavage system
DSM104443_RS01750	COG3276	selenocysteine insertion sequence binding
DSM104443_RS01790	COG4149	molybdate abc transporter
DSM104443_RS01795	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSM104443_RS01805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSM104443_RS01810	COG1910	domain protein
DSM104443_RS01825	COG3383	formate dehydrogenase (NAD+) activity
DSM104443_RS01830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM104443_RS01840	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM104443_RS01845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM104443_RS01850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DSM104443_RS01870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DSM104443_RS01875	COG0237	dephospho-CoA kinase activity
DSM104443_RS01880	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DSM104443_RS01885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSM104443_RS01900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSM104443_RS01905	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSM104443_RS01915	COG1845	cytochrome c oxidase, subunit III
DSM104443_RS01935	COG0109	protoheme IX farnesyltransferase activity
DSM104443_RS01940	COG1999	signal sequence binding
DSM104443_RS01950	COG2177	Part of the ABC transporter FtsEX involved in
DSM104443_RS01955	COG2884	Cell division ATP-binding protein ftsE
DSM104443_RS01965	COG0742	ribosomal rna small subunit methyltransferase
DSM104443_RS01970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM104443_RS01975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSM104443_RS01985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM104443_RS02000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DSM104443_RS02010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSM104443_RS02015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DSM104443_RS02020	COG0193	aminoacyl-tRNA hydrolase activity
DSM104443_RS02025	COG0012	GTP binding
DSM104443_RS02065	COG1702	phosphate starvation-inducible protein PhoH
DSM104443_RS02070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DSM104443_RS02075	COG4535	Mg2 and Co2 transporter CorC
DSM104443_RS02080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM104443_RS02090	COG0752	glycyl-tRNA synthetase alpha subunit
DSM104443_RS02095	COG0751	glycine-tRNA ligase activity
DSM104443_RS02100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSM104443_RS02125	COG0028	Belongs to the TPP enzyme family
DSM104443_RS02130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM104443_RS02135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM104443_RS02140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104443_RS02145	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSM104443_RS02160	COG0006	proline dipeptidase activity
DSM104443_RS02165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104443_RS02170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104443_RS02185	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DSM104443_RS02190	COG2967	ApaG domain
DSM104443_RS02195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSM104443_RS02200	COG0546	phosphoglycolate phosphatase activity
DSM104443_RS02215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM104443_RS02220	COG0134	indole-3-glycerol-phosphate synthase activity
DSM104443_RS02230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DSM104443_RS02240	COG0628	permease
DSM104443_RS02245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM104443_RS02250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM104443_RS02255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSM104443_RS02270	COG0316	Belongs to the HesB IscA family
DSM104443_RS02275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSM104443_RS02280	COG4942	peptidase
DSM104443_RS02285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM104443_RS02320	COG4941	Belongs to the sigma-70 factor family
DSM104443_RS02325	COG3795	YCII-related domain
DSM104443_RS02350	COG0308	aminopeptidase N
DSM104443_RS02355	COG0513	Belongs to the DEAD box helicase family
DSM104443_RS02365	COG3909	cytochrome
DSM104443_RS02375	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS02380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104443_RS02435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM104443_RS02445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104443_RS02445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DSM104443_RS02455	COG0793	Belongs to the peptidase S41A family
DSM104443_RS02470	COG3706	GGDEF domain
DSM104443_RS02475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104443_RS02495	COG5002	protein histidine kinase activity
DSM104443_RS02495	COG5001	Diguanylate cyclase
DSM104443_RS02495	COG3447	MASE1 domain protein
DSM104443_RS02500	COG1127	ABC transporter
DSM104443_RS02510	COG1053	succinate dehydrogenase
DSM104443_RS02530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104443_RS02545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSM104443_RS02570	COG0602	queuosine metabolic process
DSM104443_RS02580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSM104443_RS02640	COG0488	(ABC) transporter
DSM104443_RS02655	COG0673	inositol 2-dehydrogenase activity
DSM104443_RS02660	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS02680	COG0129	dihydroxy-acid dehydratase activity
DSM104443_RS02700	COG0667	Aldo Keto reductase
DSM104443_RS02720	COG0515	serine threonine protein kinase
DSM104443_RS02730	COG1295	ribonuclease BN
DSM104443_RS02780	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DSM104443_RS02785	COG2072	flavoprotein involved in K transport
DSM104443_RS02800	COG3275	phosphorelay sensor kinase activity
DSM104443_RS02805	COG2207	Transcriptional regulator
DSM104443_RS02870	COG1408	metallophosphoesterase
DSM104443_RS02905	COG1473	amidohydrolase
DSM104443_RS02960	COG4774	siderophore transport
DSM104443_RS02975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS03000	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104443_RS03005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104443_RS03025	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS03030	COG2188	Transcriptional regulator
DSM104443_RS03035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS03045	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS03060	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM104443_RS03065	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSM104443_RS03080	COG1278	Cold shock
DSM104443_RS03090	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS03145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104443_RS03185	COG0540	Belongs to the ATCase OTCase family
DSM104443_RS03195	COG1131	(ABC) transporter
DSM104443_RS03215	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS03235	COG0584	glycerophosphoryl diester phosphodiesterase
DSM104443_RS03240	COG3384	dioxygenase
DSM104443_RS03250	COG3409	Peptidoglycan-binding domain 1 protein
DSM104443_RS03250	COG0793	Belongs to the peptidase S41A family
DSM104443_RS03270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM104443_RS03290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSM104443_RS03295	COG0004	ammonium transporteR
DSM104443_RS03310	COG0277	FAD linked oxidase domain protein
DSM104443_RS03315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DSM104443_RS03335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104443_RS03355	COG0300	oxidoreductase activity
DSM104443_RS03365	COG2823	Periplasmic or secreted lipoprotein
DSM104443_RS03370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DSM104443_RS03375	COG0792	nuclease activity
DSM104443_RS03385	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM104443_RS03390	COG0418	dihydroorotase activity
DSM104443_RS03410	COG1175	transmembrane transport
DSM104443_RS03415	COG0395	ABC-type sugar transport system, permease component
DSM104443_RS03420	COG4948	Mandelate Racemase Muconate Lactonizing
DSM104443_RS03430	COG3842	ATPase activity
DSM104443_RS03435	COG3734	2-keto-3-deoxy-galactonokinase
DSM104443_RS03440	COG0800	Aldolase
DSM104443_RS03460	COG2001	Belongs to the MraZ family
DSM104443_RS03465	COG0275	rRNA processing
DSM104443_RS03480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM104443_RS03485	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DSM104443_RS03490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104443_RS03495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM104443_RS03500	COG0772	Belongs to the SEDS family
DSM104443_RS03505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSM104443_RS03510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104443_RS03515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSM104443_RS03520	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM104443_RS03525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSM104443_RS03550	COG3064	Membrane
DSM104443_RS03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM104443_RS03570	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DSM104443_RS03585	COG0739	heme binding
DSM104443_RS03590	COG0653	protein targeting
DSM104443_RS03595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DSM104443_RS03615	COG0494	nUDIX hydrolase
DSM104443_RS03620	COG1228	amidohydrolase
DSM104443_RS03625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104443_RS03630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
DSM104443_RS03635	COG1116	anion transmembrane transporter activity
DSM104443_RS03635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS03640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104443_RS03645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS03655	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DSM104443_RS03660	COG2226	methyltransferase
DSM104443_RS03665	COG2267	carboxylic ester hydrolase activity
DSM104443_RS03670	COG0156	8-amino-7-oxononanoate synthase activity
DSM104443_RS03675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DSM104443_RS03685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DSM104443_RS03690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSM104443_RS03700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DSM104443_RS03710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DSM104443_RS03725	COG0588	phosphoglycerate mutase activity
DSM104443_RS03735	COG0793	Belongs to the peptidase S41A family
DSM104443_RS03740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSM104443_RS03755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSM104443_RS03760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM104443_RS03810	COG1832	CoA-binding protein
DSM104443_RS03820	COG0330	HflC and HflK could
DSM104443_RS03835	COG0789	Transcriptional regulator
DSM104443_RS03855	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS03860	COG0183	Belongs to the thiolase family
DSM104443_RS03890	COG4269	membrane
DSM104443_RS03895	COG0501	Belongs to the peptidase M48B family
DSM104443_RS03900	COG1022	Amp-dependent synthetase and ligase
DSM104443_RS03910	COG2130	NADP-dependent
DSM104443_RS03925	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSM104443_RS03925	COG1024	Enoyl-CoA hydratase
DSM104443_RS03935	COG0183	Belongs to the thiolase family
DSM104443_RS03960	COG2363	Small membrane protein
DSM104443_RS03970	COG1404	Belongs to the peptidase S8 family
DSM104443_RS03975	COG3217	Mosc domain protein beta barrel domain protein
DSM104443_RS03975	COG0633	Ferredoxin
DSM104443_RS03980	COG4260	virion core protein, lumpy skin disease virus
DSM104443_RS03995	COG0678	peroxiredoxin activity
DSM104443_RS04000	COG1280	lysine exporter protein (LysE YggA)
DSM104443_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS04010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSM104443_RS04015	COG1956	GAF domain-containing protein
DSM104443_RS04070	COG0697	spore germination
DSM104443_RS04080	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSM104443_RS04090	COG2815	serine threonine protein kinase
DSM104443_RS04090	COG0515	serine threonine protein kinase
DSM104443_RS04105	COG5002	protein histidine kinase activity
DSM104443_RS04115	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS04120	COG0277	FAD linked oxidase domain protein
DSM104443_RS04125	COG0277	FAD linked oxidase domain protein
DSM104443_RS04130	COG0277	FAD linked oxidase domain protein
DSM104443_RS04135	COG0625	glutathione transferase activity
DSM104443_RS04140	COG0247	lactate metabolic process
DSM104443_RS04150	COG0254	rRNA binding
DSM104443_RS04155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM104443_RS04165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSM104443_RS04175	COG1294	oxidase, subunit
DSM104443_RS04180	COG1271	oxidase subunit
DSM104443_RS04190	COG1074	ATP-dependent DNA helicase activity
DSM104443_RS04210	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
DSM104443_RS04225	COG3132	Protein of unknown function, DUF480
DSM104443_RS04235	COG2267	carboxylic ester hydrolase activity
DSM104443_RS04275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DSM104443_RS04315	COG0756	dUTP diphosphatase activity
DSM104443_RS04320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSM104443_RS04325	COG2003	Belongs to the UPF0758 family
DSM104443_RS04330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM104443_RS04335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM104443_RS04355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSM104443_RS04355	COG3264	Mechanosensitive ion channel
DSM104443_RS04360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104443_RS04360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSM104443_RS04375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM104443_RS04380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM104443_RS04400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSM104443_RS04415	COG0617	tRNA 3'-terminal CCA addition
DSM104443_RS04425	COG1428	Deoxynucleoside kinase
DSM104443_RS04460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM104443_RS04465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DSM104443_RS04475	COG1380	Effector of murein hydrolase LrgA
DSM104443_RS04505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104443_RS04510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS04520	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS04530	COG4771	TonB-dependent receptor
DSM104443_RS04550	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS04555	COG1024	Enoyl-CoA hydratase
DSM104443_RS04565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104443_RS04575	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104443_RS04585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS04595	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS04600	COG0662	Cupin 2, conserved barrel domain protein
DSM104443_RS04620	COG1850	ribulose-bisphosphate carboxylase activity
DSM104443_RS04635	COG3008	intermembrane lipid transfer
DSM104443_RS04635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM104443_RS04640	COG2995	paraquat-inducible protein a
DSM104443_RS04660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104443_RS04660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSM104443_RS04690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DSM104443_RS04695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM104443_RS04700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSM104443_RS04710	COG0243	molybdopterin cofactor binding
DSM104443_RS04720	COG1116	anion transmembrane transporter activity
DSM104443_RS04725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104443_RS04730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS04735	COG3707	response regulator
DSM104443_RS04745	COG2274	protein secretion by the type I secretion system
DSM104443_RS04750	COG2274	protein secretion by the type I secretion system
DSM104443_RS04825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DSM104443_RS04840	COG0583	DNA-binding transcription factor activity
DSM104443_RS04855	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSM104443_RS04865	COG0697	spore germination
DSM104443_RS04870	COG2153	protein acetylation
DSM104443_RS04875	COG0354	folic acid binding
DSM104443_RS04885	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM104443_RS04885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104443_RS04910	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS04930	COG1595	DNA-templated transcription, initiation
DSM104443_RS04940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104443_RS04950	COG2350	Protein conserved in bacteria
DSM104443_RS04955	COG2917	probably involved in intracellular septation
DSM104443_RS04965	COG0613	PHP domain protein
DSM104443_RS04970	COG0009	L-threonylcarbamoyladenylate synthase
DSM104443_RS04975	COG1994	Peptidase M50
DSM104443_RS04980	COG0180	Tryptophanyl-tRNA synthetase
DSM104443_RS04990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DSM104443_RS04995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DSM104443_RS05015	COG0583	DNA-binding transcription factor activity
DSM104443_RS05030	COG1335	isochorismatase
DSM104443_RS05045	COG2084	Dehydrogenase
DSM104443_RS05060	COG0259	pyridoxamine-phosphate oxidase activity
DSM104443_RS05110	COG2171	N-acyltransferase activity
DSM104443_RS05125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104443_RS05140	COG2226	methyltransferase
DSM104443_RS05150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM104443_RS05155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104443_RS05175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSM104443_RS05190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM104443_RS05195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DSM104443_RS05210	COG0242	peptide deformylase activity
DSM104443_RS05245	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DSM104443_RS05250	COG0024	Methionine aminopeptidase
DSM104443_RS05255	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM104443_RS05260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DSM104443_RS05265	COG0528	UMP kinase activity
DSM104443_RS05270	COG0233	cytoplasmic translational termination
DSM104443_RS05275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSM104443_RS05280	COG0575	Belongs to the CDS family
DSM104443_RS05285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DSM104443_RS05305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104443_RS05310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104443_RS05315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104443_RS05320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104443_RS05325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSM104443_RS05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104443_RS05340	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSM104443_RS05355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DSM104443_RS05365	COG2153	protein acetylation
DSM104443_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS05380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104443_RS05385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DSM104443_RS05410	COG2815	serine threonine protein kinase
DSM104443_RS05410	COG0515	serine threonine protein kinase
DSM104443_RS05425	COG1297	OPT oligopeptide transporter protein
DSM104443_RS05475	COG2226	methyltransferase
DSM104443_RS05530	COG0601	transmembrane transport
DSM104443_RS05535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104443_RS05540	COG0444	Belongs to the ABC transporter superfamily
DSM104443_RS05545	COG4608	Belongs to the ABC transporter superfamily
DSM104443_RS05565	COG0251	oxidation-reduction process
DSM104443_RS05580	COG0640	Transcriptional regulator
DSM104443_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS05610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM104443_RS05705	COG1793	dna ligase
DSM104443_RS05705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSM104443_RS05710	COG1793	dna ligase
DSM104443_RS05715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104443_RS05740	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
DSM104443_RS05745	COG1201	RNA secondary structure unwinding
DSM104443_RS05785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSM104443_RS05790	COG0670	Belongs to the BI1 family
DSM104443_RS05830	COG0454	-acetyltransferase
DSM104443_RS05845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS05850	COG2186	Transcriptional regulator
DSM104443_RS05855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104443_RS05870	COG5001	Diguanylate cyclase
DSM104443_RS05875	COG0527	aspartate kinase activity
DSM104443_RS05880	COG1505	serine-type exopeptidase activity
DSM104443_RS05885	COG2982	Protein involved in outer membrane biogenesis
DSM104443_RS05895	COG0582	viral genome integration into host DNA
DSM104443_RS05970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DSM104443_RS05975	COG2205	protein histidine kinase activity
DSM104443_RS05975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104443_RS06015	COG0300	oxidoreductase activity
DSM104443_RS06040	COG2020	methyltransferase activity
DSM104443_RS06045	COG0596	Alpha beta hydrolase
DSM104443_RS06050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSM104443_RS06060	COG3300	MHYT domain
DSM104443_RS06060	COG5001	Diguanylate cyclase
DSM104443_RS06075	COG1612	heme a metabolic process
DSM104443_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS06095	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104443_RS06105	COG2084	Dehydrogenase
DSM104443_RS06110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104443_RS06120	COG4177	L-phenylalanine transmembrane transporter activity
DSM104443_RS06125	COG1137	ATPase activity
DSM104443_RS06135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DSM104443_RS06170	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104443_RS06200	COG0628	permease
DSM104443_RS06225	COG1012	belongs to the aldehyde dehydrogenase family
DSM104443_RS06230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DSM104443_RS06250	COG2318	DinB family
DSM104443_RS06260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSM104443_RS06280	COG1283	sodium-dependent phosphate transmembrane transporter activity
DSM104443_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
DSM104443_RS06315	COG4172	Belongs to the ABC transporter superfamily
DSM104443_RS06320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104443_RS06355	COG0583	DNA-binding transcription factor activity
DSM104443_RS06360	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104443_RS06365	COG3842	ATPase activity
DSM104443_RS06375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104443_RS06420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104443_RS06425	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DSM104443_RS06430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DSM104443_RS06430	COG0321	lipoyl(octanoyl) transferase activity
DSM104443_RS06445	COG2850	peptidyl-arginine hydroxylation
DSM104443_RS06450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104443_RS06465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSM104443_RS06485	COG1652	LysM domain
DSM104443_RS06490	COG1252	NADH dehydrogenase
DSM104443_RS06525	COG1045	serine acetyltransferase
DSM104443_RS06535	COG1104	cysteine desulfurase activity
DSM104443_RS06540	COG0822	iron-sulfur transferase activity
DSM104443_RS06545	COG0316	Belongs to the HesB IscA family
DSM104443_RS06550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM104443_RS06560	COG0443	Heat shock 70 kDa protein
DSM104443_RS06565	COG0633	Ferredoxin
DSM104443_RS06595	COG4772	TonB-dependent receptor
DSM104443_RS06600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSM104443_RS06600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104443_RS06605	COG2204	response regulator
DSM104443_RS06615	COG2205	protein histidine kinase activity
DSM104443_RS06625	COG0560	Phosphoserine phosphatase
DSM104443_RS06630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM104443_RS06655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104443_RS06665	COG5002	protein histidine kinase activity
DSM104443_RS06670	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS06695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM104443_RS06735	COG0028	Belongs to the TPP enzyme family
DSM104443_RS06745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM104443_RS06750	COG0688	phosphatidylethanolamine metabolic process
DSM104443_RS06755	COG1183	phosphatidylcholine synthase activity
DSM104443_RS06760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104443_RS06770	COG0656	L-ascorbic acid biosynthetic process
DSM104443_RS06785	COG0625	glutathione transferase activity
DSM104443_RS06790	COG0482	sulfurtransferase activity
DSM104443_RS06805	COG0538	isocitrate dehydrogenase activity
DSM104443_RS06810	COG1278	Cold shock
DSM104443_RS06815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DSM104443_RS06820	COG0542	response to heat
DSM104443_RS06830	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSM104443_RS06835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104443_RS06845	COG1309	transcriptional regulator
DSM104443_RS06850	COG0433	COG0433 Predicted ATPase
DSM104443_RS06855	COG0217	transcriptional regulatory protein
DSM104443_RS06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DSM104443_RS06865	COG0632	four-way junction helicase activity
DSM104443_RS06870	COG2255	four-way junction helicase activity
DSM104443_RS06875	COG0824	Thioesterase
DSM104443_RS06895	COG0823	Involved in the tonB-independent uptake of proteins
DSM104443_RS06905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DSM104443_RS06910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DSM104443_RS06935	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DSM104443_RS06940	COG1247	-acetyltransferase
DSM104443_RS06950	COG2205	protein histidine kinase activity
DSM104443_RS06960	COG4206	TonB-dependent receptor
DSM104443_RS06965	COG0779	Required for maturation of 30S ribosomal subunits
DSM104443_RS06970	COG2251	uridine kinase activity
DSM104443_RS06970	COG0195	Participates in both transcription termination and antitermination
DSM104443_RS06975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSM104443_RS06980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DSM104443_RS06985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSM104443_RS06990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM104443_RS06995	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM104443_RS07020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM104443_RS07025	COG2914	Belongs to the UPF0125 (RnfH) family
DSM104443_RS07055	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104443_RS07055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSM104443_RS07085	COG1393	Belongs to the ArsC family
DSM104443_RS07100	COG1254	Belongs to the acylphosphatase family
DSM104443_RS07110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104443_RS07110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104443_RS07115	COG0489	protein tyrosine kinase activity
DSM104443_RS07120	COG0717	Belongs to the dCTP deaminase family
DSM104443_RS07125	COG0019	diaminopimelate decarboxylase activity
DSM104443_RS07165	COG1476	TRANSCRIPTIONal
DSM104443_RS07195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DSM104443_RS07200	COG3104	oligopeptide transport
DSM104443_RS07235	COG1355	regulation of microtubule-based process
DSM104443_RS07240	COG2078	PFAM AMMECR1 domain protein
DSM104443_RS07255	COG1162	GTPase activity
DSM104443_RS07260	COG2154	pterin-4-alpha-carbinolamine dehydratase
DSM104443_RS07265	COG0501	Belongs to the peptidase M48B family
DSM104443_RS07270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DSM104443_RS07275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSM104443_RS07295	COG0395	ABC-type sugar transport system, permease component
DSM104443_RS07310	COG1546	Belongs to the CinA family
DSM104443_RS07315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM104443_RS07320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM104443_RS07325	COG2137	regulation of response to DNA damage stimulus
DSM104443_RS07335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM104443_RS07345	COG0438	transferase activity, transferring glycosyl groups
DSM104443_RS07350	COG2816	NAD+ diphosphatase activity
DSM104443_RS07360	COG1131	(ABC) transporter
DSM104443_RS07370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104443_RS07375	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104443_RS07380	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM104443_RS07385	COG0631	protein serine/threonine phosphatase activity
DSM104443_RS07400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104443_RS07405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DSM104443_RS07440	COG3258	Cytochrome c
DSM104443_RS07450	COG4783	chaperone-mediated protein folding
DSM104443_RS07455	COG0315	cyclic pyranopterin monophosphate synthase activity
DSM104443_RS07470	COG0425	Belongs to the sulfur carrier protein TusA family
DSM104443_RS07480	COG1024	Enoyl-CoA hydratase
DSM104443_RS07490	COG0525	valine-tRNA ligase activity
DSM104443_RS07505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104443_RS07525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSM104443_RS07545	COG0493	'glutamate synthase
DSM104443_RS07545	COG0543	2 iron, 2 sulfur cluster binding
DSM104443_RS07550	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DSM104443_RS07560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM104443_RS07585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSM104443_RS07625	COG1450	Type ii and iii secretion system protein
DSM104443_RS07630	COG3338	carbonate dehydratase activity
DSM104443_RS07635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DSM104443_RS07635	COG1672	PFAM Archaeal ATPase
DSM104443_RS07655	COG1404	Belongs to the peptidase S8 family
DSM104443_RS07690	COG0471	metal ion transport
DSM104443_RS07700	COG1301	dicarboxylic acid transport
DSM104443_RS07710	COG4566	intracellular signal transduction
DSM104443_RS07715	COG2198	Histidine kinase
DSM104443_RS07715	COG2205	protein histidine kinase activity
DSM104443_RS07715	COG0784	Response regulator, receiver
DSM104443_RS07720	COG4191	Histidine kinase
DSM104443_RS07725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSM104443_RS07735	COG3791	Glutathione-dependent formaldehyde-activating
DSM104443_RS07760	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSM104443_RS07770	COG3023	N-Acetylmuramoyl-L-alanine amidase
DSM104443_RS07775	COG4166	transmembrane transport
DSM104443_RS07780	COG0700	Nucleoside recognition
DSM104443_RS07805	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSM104443_RS07830	COG0204	Acyl-transferase
DSM104443_RS07850	COG0436	Aminotransferase
DSM104443_RS07870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSM104443_RS07895	COG0322	excinuclease ABC activity
DSM104443_RS07920	COG0640	Transcriptional regulator
DSM104443_RS07935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104443_RS07950	COG1917	Cupin 2, conserved barrel domain protein
DSM104443_RS07950	COG4977	sequence-specific DNA binding
DSM104443_RS07965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104443_RS07975	COG1566	PFAM secretion protein HlyD family protein
DSM104443_RS07980	COG2814	Major facilitator Superfamily
DSM104443_RS07985	COG0066	3-isopropylmalate dehydratase activity
DSM104443_RS07990	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS08005	COG0101	tRNA pseudouridine synthase activity
DSM104443_RS08010	COG0135	phosphoribosylanthranilate isomerase activity
DSM104443_RS08015	COG0133	tryptophan synthase activity
DSM104443_RS08020	COG0159	tryptophan synthase activity
DSM104443_RS08025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM104443_RS08030	COG0285	dihydrofolate synthase activity
DSM104443_RS08065	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104443_RS08075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSM104443_RS08090	COG0215	cysteine-tRNA ligase activity
DSM104443_RS08100	COG0484	heat shock protein binding
DSM104443_RS08105	COG0443	Heat shock 70 kDa protein
DSM104443_RS08110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM104443_RS08115	COG1950	PFAM Membrane protein of
DSM104443_RS08120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DSM104443_RS08125	COG1420	regulation of RNA biosynthetic process
DSM104443_RS08130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSM104443_RS08135	COG0497	DNA recombination
DSM104443_RS08150	COG0400	carboxylic ester hydrolase activity
DSM104443_RS08155	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM104443_RS08160	COG3028	Belongs to the UPF0307 family
DSM104443_RS08165	COG0312	modulator of DNA gyrase
DSM104443_RS08170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104443_RS08180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSM104443_RS08185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS08205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104443_RS08210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM104443_RS08215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104443_RS08215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104443_RS08235	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM104443_RS08240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104443_RS08245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DSM104443_RS08250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM104443_RS08255	COG0584	glycerophosphoryl diester phosphodiesterase
DSM104443_RS08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104443_RS08280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DSM104443_RS08280	COG0678	peroxiredoxin activity
DSM104443_RS08285	COG0583	DNA-binding transcription factor activity
DSM104443_RS08310	COG0247	lactate metabolic process
DSM104443_RS08315	COG1592	Rubrerythrin
DSM104443_RS08340	COG2264	protein methyltransferase activity
DSM104443_RS08355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DSM104443_RS08400	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSM104443_RS08415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DSM104443_RS08425	COG2329	Antibiotic biosynthesis monooxygenase
DSM104443_RS08450	COG1174	glycine betaine transport
DSM104443_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS08465	COG0129	dihydroxy-acid dehydratase activity
DSM104443_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104443_RS08475	COG3842	ATPase activity
DSM104443_RS08485	COG1175	transmembrane transport
DSM104443_RS08490	COG3833	ABC-type maltose transport systems, permease component
DSM104443_RS08510	COG0484	heat shock protein binding
DSM104443_RS08525	COG0840	transmembrane signaling receptor activity
DSM104443_RS08530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104443_RS08535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104443_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS08560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSM104443_RS08565	COG2721	sulfolactate sulfo-lyase activity
DSM104443_RS08570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104443_RS08585	COG0154	amidase activity
DSM104443_RS08590	COG0596	Alpha beta hydrolase
DSM104443_RS08610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104443_RS08630	COG0741	lytic transglycosylase activity
DSM104443_RS08635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSM104443_RS08640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS08660	COG0517	IMP dehydrogenase activity
DSM104443_RS08665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104443_RS08675	COG0187	DNA topoisomerase II activity
DSM104443_RS08685	COG2199	diguanylate cyclase activity
DSM104443_RS08685	COG2200	EAL domain
DSM104443_RS08685	COG2203	Gaf domain
DSM104443_RS08690	COG2205	protein histidine kinase activity
DSM104443_RS08690	COG0784	Response regulator, receiver
DSM104443_RS08700	COG1309	transcriptional regulator
DSM104443_RS08705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS08715	COG1538	Outer membrane efflux protein
DSM104443_RS08780	COG3128	pkhd-type hydroxylase
DSM104443_RS08795	COG2205	protein histidine kinase activity
DSM104443_RS08815	COG4251	negative regulation of phosphorylation
DSM104443_RS08825	COG4771	TonB-dependent receptor
DSM104443_RS08830	COG5002	protein histidine kinase activity
DSM104443_RS08835	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS08850	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS08865	COG0840	transmembrane signaling receptor activity
DSM104443_RS08870	COG0477	Major facilitator Superfamily
DSM104443_RS08905	COG0582	viral genome integration into host DNA
DSM104443_RS08990	COG2358	TRAP transporter, solute receptor (TAXI family
DSM104443_RS08995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM104443_RS09025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM104443_RS09125	COG1309	transcriptional regulator
DSM104443_RS09155	COG0697	spore germination
DSM104443_RS09180	COG1595	DNA-templated transcription, initiation
DSM104443_RS09200	COG1392	Phosphate transport regulator
DSM104443_RS09205	COG0306	phosphate transporter
DSM104443_RS09225	COG2828	Protein conserved in bacteria
DSM104443_RS09270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DSM104443_RS09280	COG2079	MmgE PrpD family protein
DSM104443_RS09305	COG2030	dehydratase
DSM104443_RS09310	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104443_RS09325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DSM104443_RS09330	COG1053	succinate dehydrogenase
DSM104443_RS09335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSM104443_RS09340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DSM104443_RS09345	COG0372	Belongs to the citrate synthase family
DSM104443_RS09350	COG0567	Dehydrogenase, E1 component
DSM104443_RS09355	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSM104443_RS09375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSM104443_RS09380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSM104443_RS09385	COG0604	alcohol dehydrogenase
DSM104443_RS09410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSM104443_RS09415	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS09430	COG1024	Enoyl-CoA hydratase
DSM104443_RS09475	COG0137	argininosuccinate synthase activity
DSM104443_RS09485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSM104443_RS09485	COG2022	thiamine diphosphate biosynthetic process
DSM104443_RS09505	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS09510	COG1971	Probably functions as a manganese efflux pump
DSM104443_RS09520	COG2133	pyrroloquinoline quinone binding
DSM104443_RS09545	COG5002	protein histidine kinase activity
DSM104443_RS09545	COG5001	Diguanylate cyclase
DSM104443_RS09550	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM104443_RS09555	COG1024	Enoyl-CoA hydratase
DSM104443_RS09560	COG1024	Enoyl-CoA hydratase
DSM104443_RS09575	COG2985	domain, Protein
DSM104443_RS09620	COG3119	arylsulfatase activity
DSM104443_RS09640	COG4566	intracellular signal transduction
DSM104443_RS09645	COG4191	Histidine kinase
DSM104443_RS09700	COG4770	biotin carboxylase activity
DSM104443_RS09710	COG1024	Enoyl-CoA hydratase
DSM104443_RS09715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104443_RS09730	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS09745	COG0183	Belongs to the thiolase family
DSM104443_RS09755	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS09770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104443_RS09780	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS09785	COG0066	3-isopropylmalate dehydratase activity
DSM104443_RS09795	COG0583	DNA-binding transcription factor activity
DSM104443_RS09800	COG2159	amidohydrolase
DSM104443_RS09805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM104443_RS09820	COG1022	Amp-dependent synthetase and ligase
DSM104443_RS09830	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104443_RS09855	COG3842	ATPase activity
DSM104443_RS09860	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104443_RS09880	COG0412	Dienelactone hydrolase
DSM104443_RS09900	COG4555	ABC transporter
DSM104443_RS09905	COG1668	transmembrane transport
DSM104443_RS09910	COG1199	ATP-dependent helicase activity
DSM104443_RS09930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DSM104443_RS09935	COG2205	protein histidine kinase activity
DSM104443_RS09940	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS09960	COG1214	PFAM Peptidase M22, glycoprotease
DSM104443_RS09970	COG1573	uracil-dna glycosylase
DSM104443_RS09990	COG1414	Transcriptional regulator
DSM104443_RS10000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS10010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DSM104443_RS10025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM104443_RS10030	COG4133	protoheme IX ABC transporter activity
DSM104443_RS10070	COG0492	ferredoxin-NADP+ reductase activity
DSM104443_RS10080	COG0477	Major facilitator Superfamily
DSM104443_RS10120	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS10125	COG0643	Histidine kinase
DSM104443_RS10125	COG2198	Histidine kinase
DSM104443_RS10130	COG0840	transmembrane signaling receptor activity
DSM104443_RS10135	COG0840	transmembrane signaling receptor activity
DSM104443_RS10140	COG0835	chemotaxis
DSM104443_RS10145	COG0840	transmembrane signaling receptor activity
DSM104443_RS10155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DSM104443_RS10160	COG2201	protein-glutamate methylesterase activity
DSM104443_RS10165	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSM104443_RS10165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSM104443_RS10170	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSM104443_RS10185	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DSM104443_RS10200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DSM104443_RS10205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104443_RS10215	COG0737	Belongs to the 5'-nucleotidase family
DSM104443_RS10215	COG1525	nuclease
DSM104443_RS10215	COG4085	toxin activity
DSM104443_RS10235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104443_RS10250	COG2346	COG2346, Truncated hemoglobins
DSM104443_RS10265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DSM104443_RS10270	COG1322	Protein conserved in bacteria
DSM104443_RS10275	COG0028	Belongs to the TPP enzyme family
DSM104443_RS10290	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM104443_RS10295	COG0596	Alpha beta hydrolase
DSM104443_RS10310	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS10325	COG4677	pectinesterase activity
DSM104443_RS10345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSM104443_RS10355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS10360	COG1609	Transcriptional regulator
DSM104443_RS10365	COG1763	Mo-molybdopterin cofactor biosynthetic process
DSM104443_RS10370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DSM104443_RS10375	COG0314	molybdopterin synthase activity
DSM104443_RS10380	COG0640	Transcriptional regulator
DSM104443_RS10385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM104443_RS10390	COG4654	Cytochrome c, class I
DSM104443_RS10420	COG0737	Belongs to the 5'-nucleotidase family
DSM104443_RS10520	COG0640	Transcriptional regulator
DSM104443_RS10525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSM104443_RS10540	COG0587	DNA-directed DNA polymerase activity
DSM104443_RS10555	COG4206	TonB-dependent receptor
DSM104443_RS10575	COG4771	TonB-dependent receptor
DSM104443_RS10590	COG0683	leucine binding
DSM104443_RS10595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM104443_RS10610	COG0561	phosphatase activity
DSM104443_RS10620	COG0297	glycogen (starch) synthase activity
DSM104443_RS10625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DSM104443_RS10630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DSM104443_RS10650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DSM104443_RS10675	COG0673	inositol 2-dehydrogenase activity
DSM104443_RS10690	COG5002	protein histidine kinase activity
DSM104443_RS10700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DSM104443_RS10710	COG0673	inositol 2-dehydrogenase activity
DSM104443_RS10720	COG2204	response regulator
DSM104443_RS10725	COG2204	response regulator
DSM104443_RS10730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM104443_RS10740	COG3237	CsbD-like
DSM104443_RS10770	COG0114	fumarate hydratase activity
DSM104443_RS10775	COG3038	cytochrome b561
DSM104443_RS10785	COG2353	YceI-like domain
DSM104443_RS10800	COG0823	Involved in the tonB-independent uptake of proteins
DSM104443_RS10800	COG1506	peptidase
DSM104443_RS10800	COG4946	Tricorn protease homolog
DSM104443_RS10825	COG0672	)-iron permease
DSM104443_RS10830	COG4774	siderophore transport
DSM104443_RS10855	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS10885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSM104443_RS10890	COG0277	FAD linked oxidase domain protein
DSM104443_RS10890	COG0247	lactate metabolic process
DSM104443_RS10895	COG1802	Transcriptional regulator
DSM104443_RS10900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104443_RS10930	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DSM104443_RS10935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104443_RS10940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM104443_RS10940	COG2010	Cytochrome c
DSM104443_RS10950	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS11005	COG4221	oxidoreductase activity
DSM104443_RS11010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104443_RS11025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104443_RS11030	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DSM104443_RS11040	COG0084	hydrolase, TatD family'
DSM104443_RS11045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104443_RS11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM104443_RS11065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSM104443_RS11070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104443_RS11075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104443_RS11080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM104443_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS11095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104443_RS11100	COG0416	fatty acid biosynthetic process
DSM104443_RS11105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM104443_RS11115	COG0424	maF-like protein
DSM104443_RS11120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM104443_RS11130	COG0616	signal peptide processing
DSM104443_RS11140	COG0546	phosphoglycolate phosphatase activity
DSM104443_RS11145	COG0564	pseudouridine synthase activity
DSM104443_RS11150	COG1530	ribonuclease E activity
DSM104443_RS11165	COG3209	COG3209 Rhs family protein
DSM104443_RS11185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM104443_RS11195	COG0556	nucleotide-excision repair
DSM104443_RS11200	COG0436	Aminotransferase
DSM104443_RS11245	COG0281	malic enzyme
DSM104443_RS11250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104443_RS11265	COG4585	Histidine kinase
DSM104443_RS11270	COG2197	response regulator
DSM104443_RS11275	COG2202	Pas domain
DSM104443_RS11275	COG2205	protein histidine kinase activity
DSM104443_RS11280	COG0784	Response regulator, receiver
DSM104443_RS11295	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DSM104443_RS11300	COG4251	negative regulation of phosphorylation
DSM104443_RS11330	COG0288	reversible hydration of carbon dioxide
DSM104443_RS11345	COG0667	Aldo Keto reductase
DSM104443_RS11355	COG4214	carbohydrate transport
DSM104443_RS11360	COG4213	ABC transporter substrate-binding protein
DSM104443_RS11365	COG2115	Belongs to the xylose isomerase family
DSM104443_RS11370	COG2115	Belongs to the xylose isomerase family
DSM104443_RS11375	COG1070	Carbohydrate kinase
DSM104443_RS11385	COG0395	ABC-type sugar transport system, permease component
DSM104443_RS11390	COG1175	transmembrane transport
DSM104443_RS11400	COG1609	Transcriptional regulator
DSM104443_RS11410	COG3661	Belongs to the glycosyl hydrolase 67 family
DSM104443_RS11420	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM104443_RS11565	COG3507	Belongs to the glycosyl hydrolase 43 family
DSM104443_RS11610	COG1566	PFAM secretion protein HlyD family protein
DSM104443_RS11615	COG1538	Outer membrane efflux protein
DSM104443_RS11635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104443_RS11640	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS11645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104443_RS11665	COG1187	pseudouridine synthase activity
DSM104443_RS11675	COG2264	protein methyltransferase activity
DSM104443_RS11690	COG0601	transmembrane transport
DSM104443_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104443_RS11700	COG0444	Belongs to the ABC transporter superfamily
DSM104443_RS11705	COG4608	Belongs to the ABC transporter superfamily
DSM104443_RS11720	COG3246	L-lysine catabolic process to acetate
DSM104443_RS11730	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS11735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104443_RS11785	COG1595	DNA-templated transcription, initiation
DSM104443_RS11795	COG2197	response regulator
DSM104443_RS11815	COG3781	membrane
DSM104443_RS11830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104443_RS11895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS11930	COG0596	Alpha beta hydrolase
DSM104443_RS11940	COG2197	response regulator
DSM104443_RS11945	COG4585	Histidine kinase
DSM104443_RS11950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS11965	COG0596	Alpha beta hydrolase
DSM104443_RS11970	COG0596	Alpha beta hydrolase
DSM104443_RS11980	COG4566	intracellular signal transduction
DSM104443_RS11985	COG4566	intracellular signal transduction
DSM104443_RS12015	COG0322	excinuclease ABC activity
DSM104443_RS12020	COG1472	Belongs to the glycosyl hydrolase 3 family
DSM104443_RS12025	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM104443_RS12030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSM104443_RS12035	COG1381	Involved in DNA repair and RecF pathway recombination
DSM104443_RS12040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM104443_RS12045	COG0571	ribonuclease III activity
DSM104443_RS12055	COG0681	Belongs to the peptidase S26 family
DSM104443_RS12060	COG0481	GTPase activity
DSM104443_RS12070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104443_RS12090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSM104443_RS12095	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM104443_RS12095	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM104443_RS12105	COG0617	tRNA 3'-terminal CCA addition
DSM104443_RS12105	COG0517	IMP dehydrogenase activity
DSM104443_RS12105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DSM104443_RS12115	COG1136	(ABC) transporter
DSM104443_RS12130	COG2755	lipolytic protein G-D-S-L family
DSM104443_RS12130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DSM104443_RS12135	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104443_RS12150	COG1024	Enoyl-CoA hydratase
DSM104443_RS12155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS12170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104443_RS12185	COG2205	protein histidine kinase activity
DSM104443_RS12185	COG0784	Response regulator, receiver
DSM104443_RS12240	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS12245	COG2050	protein possibly involved in aromatic compounds catabolism
DSM104443_RS12250	COG0640	Transcriptional regulator
DSM104443_RS12260	COG3964	amidohydrolase
DSM104443_RS12355	COG2205	protein histidine kinase activity
DSM104443_RS12365	COG1183	phosphatidylcholine synthase activity
DSM104443_RS12380	COG0542	response to heat
DSM104443_RS12390	COG2853	Lipoprotein
DSM104443_RS12450	COG0436	Aminotransferase
DSM104443_RS12455	COG0484	heat shock protein binding
DSM104443_RS12475	COG2902	Dehydrogenase
DSM104443_RS12485	COG0765	amino acid transport
DSM104443_RS12490	COG0765	amino acid transport
DSM104443_RS12495	COG1126	abc transporter atp-binding protein
DSM104443_RS12505	COG0123	including yeast histone deacetylase and acetoin utilization protein
DSM104443_RS12515	COG0714	Associated with various cellular activities
DSM104443_RS12530	COG0653	protein targeting
DSM104443_RS12540	COG1388	LysM domain
DSM104443_RS12540	COG4942	peptidase
DSM104443_RS12545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104443_RS12550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DSM104443_RS12555	COG3590	peptidase
DSM104443_RS12560	COG3590	peptidase
DSM104443_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS12575	COG0509	glycine decarboxylation via glycine cleavage system
DSM104443_RS12580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSM104443_RS12585	COG2205	protein histidine kinase activity
DSM104443_RS12590	COG0156	8-amino-7-oxononanoate synthase activity
DSM104443_RS12615	COG0776	regulation of translation
DSM104443_RS12620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104443_RS12620	COG0072	phenylalanine-tRNA ligase activity
DSM104443_RS12625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM104443_RS12630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM104443_RS12635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM104443_RS12640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM104443_RS12645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSM104443_RS12650	COG0683	leucine binding
DSM104443_RS12665	COG2159	amidohydrolase
DSM104443_RS12675	COG0583	DNA-binding transcription factor activity
DSM104443_RS12680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DSM104443_RS12685	COG3384	dioxygenase
DSM104443_RS12710	COG0411	ABC transporter
DSM104443_RS12725	COG0683	leucine binding
DSM104443_RS12730	COG3485	protocatechuate 3,4-dioxygenase
DSM104443_RS12735	COG3485	protocatechuate 3,4-dioxygenase
DSM104443_RS12740	COG1414	Transcriptional regulator
DSM104443_RS12745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM104443_RS12760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DSM104443_RS12765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSM104443_RS12795	COG0829	nickel cation binding
DSM104443_RS12800	COG0831	urea catabolic process
DSM104443_RS12810	COG0804	urea catabolic process
DSM104443_RS12815	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DSM104443_RS12820	COG0830	nickel cation binding
DSM104443_RS12825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DSM104443_RS12835	COG3754	Rhamnan synthesis protein F
DSM104443_RS12845	COG0456	acetyltransferase
DSM104443_RS12870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104443_RS12880	COG2308	Evidence 4 Homologs of previously reported genes of
DSM104443_RS12930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DSM104443_RS12945	COG1136	(ABC) transporter
DSM104443_RS12960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM104443_RS12985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DSM104443_RS12995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104443_RS13000	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
DSM104443_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS13015	COG3243	poly(R)-hydroxyalkanoic acid synthase
DSM104443_RS13030	COG0564	pseudouridine synthase activity
DSM104443_RS13040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM104443_RS13065	COG5285	phytanoyl-CoA dioxygenase
DSM104443_RS13080	COG2814	Major facilitator Superfamily
DSM104443_RS13085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSM104443_RS13090	COG4181	ATPase activity
DSM104443_RS13100	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DSM104443_RS13105	COG2815	serine threonine protein kinase
DSM104443_RS13105	COG0515	serine threonine protein kinase
DSM104443_RS13115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DSM104443_RS13120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSM104443_RS13125	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSM104443_RS13135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSM104443_RS13140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM104443_RS13155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104443_RS13160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104443_RS13165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104443_RS13170	COG0564	pseudouridine synthase activity
DSM104443_RS13175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DSM104443_RS13180	COG1674	ftsk spoiiie
DSM104443_RS13190	COG0492	ferredoxin-NADP+ reductase activity
DSM104443_RS13195	COG1193	negative regulation of DNA recombination
DSM104443_RS13200	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DSM104443_RS13205	COG2076	Multidrug Resistance protein
DSM104443_RS13210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM104443_RS13220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104443_RS13220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS13225	COG3548	integral membrane protein
DSM104443_RS13235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSM104443_RS13260	COG0347	Belongs to the P(II) protein family
DSM104443_RS13285	COG1555	photosystem II stabilization
DSM104443_RS13285	COG1596	polysaccharide export
DSM104443_RS13295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS13300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DSM104443_RS13310	COG0284	orotidine-5'-phosphate decarboxylase activity
DSM104443_RS13315	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DSM104443_RS13325	COG0776	regulation of translation
DSM104443_RS13335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSM104443_RS13340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSM104443_RS13345	COG0287	Prephenate dehydrogenase
DSM104443_RS13360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104443_RS13365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSM104443_RS13380	COG0402	S-adenosylhomocysteine deaminase activity
DSM104443_RS13385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104443_RS13405	COG1794	racemase activity, acting on amino acids and derivatives
DSM104443_RS13430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSM104443_RS13450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104443_RS13465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104443_RS13490	COG2032	superoxide dismutase activity
DSM104443_RS13510	COG0437	4 iron, 4 sulfur cluster binding
DSM104443_RS13515	COG0243	molybdopterin cofactor binding
DSM104443_RS13515	COG3383	formate dehydrogenase (NAD+) activity
DSM104443_RS13545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM104443_RS13550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM104443_RS13555	COG0746	molybdenum cofactor guanylyltransferase activity
DSM104443_RS13565	COG0303	'Molybdopterin
DSM104443_RS13590	COG1309	transcriptional regulator
DSM104443_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS13615	COG0583	DNA-binding transcription factor activity
DSM104443_RS13630	COG0175	sulfate reduction
DSM104443_RS13635	COG0175	sulfate reduction
DSM104443_RS13650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DSM104443_RS13660	COG4208	sulfate ABC transporter
DSM104443_RS13665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DSM104443_RS13680	COG0450	alkyl hydroperoxide reductase
DSM104443_RS13685	COG0583	DNA-binding transcription factor activity
DSM104443_RS13690	COG0431	NADPH-dependent FMN reductase
DSM104443_RS13695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS13700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DSM104443_RS13705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS13710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104443_RS13720	COG1116	anion transmembrane transporter activity
DSM104443_RS13735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM104443_RS13740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DSM104443_RS13745	COG0167	dihydroorotate dehydrogenase activity
DSM104443_RS13750	COG0686	Belongs to the AlaDH PNT family
DSM104443_RS13755	COG2878	Part of a membrane complex involved in electron transport
DSM104443_RS13760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM104443_RS13775	COG2863	cytochrome
DSM104443_RS13785	COG1595	DNA-templated transcription, initiation
DSM104443_RS13790	COG5001	Diguanylate cyclase
DSM104443_RS13790	COG5002	protein histidine kinase activity
DSM104443_RS13800	COG0328	RNA-DNA hybrid ribonuclease activity
DSM104443_RS13810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSM104443_RS13815	COG0456	acetyltransferase
DSM104443_RS13820	COG2319	Wd-40 repeat
DSM104443_RS13820	COG3903	Transcriptional regulator
DSM104443_RS13840	COG1388	LysM domain
DSM104443_RS13840	COG0741	lytic transglycosylase activity
DSM104443_RS13845	COG0339	signal peptide processing
DSM104443_RS13855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104443_RS13860	COG0601	transmembrane transport
DSM104443_RS13865	COG4166	transmembrane transport
DSM104443_RS13870	COG4166	transmembrane transport
DSM104443_RS13885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104443_RS13905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104443_RS13910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM104443_RS13915	COG0740	serine-type endopeptidase activity
DSM104443_RS13920	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSM104443_RS13930	COG1562	ergosterol biosynthetic process
DSM104443_RS13940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DSM104443_RS13960	COG0515	serine threonine protein kinase
DSM104443_RS13960	COG2815	serine threonine protein kinase
DSM104443_RS13975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM104443_RS13985	COG0359	binds to the 23S rRNA
DSM104443_RS13990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM104443_RS14000	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM104443_RS14055	COG0612	Peptidase, M16
DSM104443_RS14060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS14095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM104443_RS14115	COG1216	Glycosyl transferase, family 2
DSM104443_RS14150	COG0438	transferase activity, transferring glycosyl groups
DSM104443_RS14155	COG2226	methyltransferase
DSM104443_RS14165	COG0667	Aldo Keto reductase
DSM104443_RS14170	COG0438	transferase activity, transferring glycosyl groups
DSM104443_RS14190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104443_RS14195	COG2192	nodulation
DSM104443_RS14200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS14205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DSM104443_RS14210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104443_RS14215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM104443_RS14225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSM104443_RS14230	COG0557	exoribonuclease II activity
DSM104443_RS14245	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM104443_RS14250	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DSM104443_RS14260	COG0330	HflC and HflK could
DSM104443_RS14265	COG0330	HflC and HflK could
DSM104443_RS14270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSM104443_RS14275	COG1923	regulation of RNA biosynthetic process
DSM104443_RS14280	COG1160	GTP binding
DSM104443_RS14290	COG2976	Protein conserved in bacteria
DSM104443_RS14295	COG0124	histidyl-tRNA synthetase
DSM104443_RS14300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM104443_RS14315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DSM104443_RS14325	COG0037	tRNA processing
DSM104443_RS14330	COG0825	malonyl-CoA metabolic process
DSM104443_RS14335	COG2096	Adenosyltransferase
DSM104443_RS14340	COG1595	DNA-templated transcription, initiation
DSM104443_RS14350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSM104443_RS14360	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DSM104443_RS14370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSM104443_RS14375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSM104443_RS14395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DSM104443_RS14415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104443_RS14430	COG0463	Glycosyl transferase, family 2
DSM104443_RS14440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS14445	COG0312	modulator of DNA gyrase
DSM104443_RS14455	COG3164	Protein of unknown function
DSM104443_RS14460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSM104443_RS14480	COG0859	PFAM glycosyl transferase family 9
DSM104443_RS14495	COG5642	Protein of unknown function (DUF2384)
DSM104443_RS14500	COG5654	RES domain protein
DSM104443_RS14510	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS14585	COG2165	general secretion pathway protein
DSM104443_RS14600	COG3156	type II secretion system protein K
DSM104443_RS14620	COG0429	hydrolase of the alpha beta-hydrolase fold
DSM104443_RS14675	COG3064	Membrane
DSM104443_RS14690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DSM104443_RS14710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSM104443_RS14715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104443_RS14720	COG2188	Transcriptional regulator
DSM104443_RS14730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DSM104443_RS14735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM104443_RS14735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104443_RS14740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSM104443_RS14740	COG2190	(PTS) system
DSM104443_RS14740	COG1263	PTS System
DSM104443_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS14760	COG0625	glutathione transferase activity
DSM104443_RS14790	COG0625	glutathione transferase activity
DSM104443_RS14835	COG1132	(ABC) transporter
DSM104443_RS14850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DSM104443_RS14865	COG2353	YceI-like domain
DSM104443_RS14875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS14880	COG3647	Membrane
DSM104443_RS14885	COG1940	carbohydrate kinase activity
DSM104443_RS14905	COG0683	leucine binding
DSM104443_RS14945	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DSM104443_RS14955	COG0861	Integral membrane protein TerC family
DSM104443_RS14965	COG0625	glutathione transferase activity
DSM104443_RS14970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DSM104443_RS14975	COG3540	Alkaline phosphatase
DSM104443_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS15005	COG1733	regulation of RNA biosynthetic process
DSM104443_RS15020	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS15045	COG1228	amidohydrolase
DSM104443_RS15060	COG3158	transport of potassium into the cell
DSM104443_RS15075	COG2135	peptidase activity
DSM104443_RS15080	COG0322	excinuclease ABC activity
DSM104443_RS15085	COG0583	DNA-binding transcription factor activity
DSM104443_RS15110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DSM104443_RS15115	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DSM104443_RS15120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM104443_RS15125	COG0842	Transport permease protein
DSM104443_RS15130	COG1131	(ABC) transporter
DSM104443_RS15145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS15235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSM104443_RS15250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM104443_RS15265	COG1538	Outer membrane efflux protein
DSM104443_RS15275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS15290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS15305	COG3459	Glycosyltransferase 36 associated
DSM104443_RS15385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104443_RS15390	COG1278	Cold shock
DSM104443_RS15460	COG2755	lipolytic protein G-D-S-L family
DSM104443_RS15470	COG2197	response regulator
DSM104443_RS15490	COG4681	YaeQ
DSM104443_RS15500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DSM104443_RS15505	COG0583	DNA-binding transcription factor activity
DSM104443_RS15510	COG4941	Belongs to the sigma-70 factor family
DSM104443_RS15520	COG3795	YCII-related domain
DSM104443_RS15530	COG3795	YCII-related domain
DSM104443_RS15555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS15570	COG3275	phosphorelay sensor kinase activity
DSM104443_RS15575	COG3279	Response regulator of the LytR AlgR family
DSM104443_RS15595	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DSM104443_RS15635	COG1309	transcriptional regulator
DSM104443_RS15640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104443_RS15655	COG1538	Outer membrane efflux protein
DSM104443_RS15665	COG0583	DNA-binding transcription factor activity
DSM104443_RS15670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DSM104443_RS15690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104443_RS15710	COG1678	Uncharacterized ACR, COG1678
DSM104443_RS15725	COG3710	Transcriptional regulator
DSM104443_RS15725	COG0457	Tetratricopeptide repeat
DSM104443_RS15740	COG2301	Belongs to the HpcH HpaI aldolase family
DSM104443_RS15745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSM104443_RS15745	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS15750	COG0583	DNA-binding transcription factor activity
DSM104443_RS15765	COG1764	response to oxidative stress
DSM104443_RS15785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104443_RS15790	COG0765	amino acid transport
DSM104443_RS15795	COG0765	amino acid transport
DSM104443_RS15810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104443_RS15835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104443_RS15840	COG4771	TonB-dependent receptor
DSM104443_RS15850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DSM104443_RS15855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DSM104443_RS15860	COG2080	2 iron, 2 sulfur cluster binding
DSM104443_RS15865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104443_RS15870	COG1690	Belongs to the RtcB family
DSM104443_RS15880	COG0297	glycogen (starch) synthase activity
DSM104443_RS15885	COG0431	NADPH-dependent FMN reductase
DSM104443_RS15895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104443_RS15910	COG1522	sequence-specific DNA binding
DSM104443_RS15920	COG0165	Argininosuccinate lyase
DSM104443_RS15930	COG0583	DNA-binding transcription factor activity
DSM104443_RS15945	COG1733	regulation of RNA biosynthetic process
DSM104443_RS15960	COG1024	Enoyl-CoA hydratase
DSM104443_RS15980	COG0667	Aldo Keto reductase
DSM104443_RS16005	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS16035	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS16055	COG0559	Belongs to the binding-protein-dependent transport system permease family
DSM104443_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS16120	COG3118	belongs to the thioredoxin family
DSM104443_RS16195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSM104443_RS16195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104443_RS16200	COG1982	Orn Lys Arg decarboxylase major
DSM104443_RS16210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM104443_RS16260	COG2205	protein histidine kinase activity
DSM104443_RS16265	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS16290	COG0142	geranyltranstransferase activity
DSM104443_RS16295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM104443_RS16300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM104443_RS16305	COG1280	lysine exporter protein (LysE YggA)
DSM104443_RS16310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSM104443_RS16315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSM104443_RS16340	COG0494	nUDIX hydrolase
DSM104443_RS16345	COG0442	prolyl-tRNA aminoacylation
DSM104443_RS16350	COG0519	Catalyzes the synthesis of GMP from XMP
DSM104443_RS16355	COG0741	lytic transglycosylase activity
DSM104443_RS16360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS16370	COG1295	ribonuclease BN
DSM104443_RS16370	COG1959	2 iron, 2 sulfur cluster binding
DSM104443_RS16390	COG0586	Pfam SNARE associated Golgi protein
DSM104443_RS16395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104443_RS16400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104443_RS16405	COG1862	Preprotein translocase
DSM104443_RS16410	COG0343	queuine tRNA-ribosyltransferase activity
DSM104443_RS16420	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DSM104443_RS16425	COG0205	6-phosphofructokinase activity
DSM104443_RS16430	COG0563	adenylate kinase activity
DSM104443_RS16440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM104443_RS16445	COG2835	tetraacyldisaccharide 4'-kinase activity
DSM104443_RS16455	COG0848	biopolymer transport protein
DSM104443_RS16465	COG1570	exodeoxyribonuclease VII activity
DSM104443_RS16470	COG3360	Dodecin
DSM104443_RS16475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSM104443_RS16480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSM104443_RS16490	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSM104443_RS16495	COG0802	atpase or kinase
DSM104443_RS16500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM104443_RS16525	COG5001	Diguanylate cyclase
DSM104443_RS16525	COG3300	MHYT domain
DSM104443_RS16555	COG4149	molybdate abc transporter
DSM104443_RS16560	COG3842	ATPase activity
DSM104443_RS16580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSM104443_RS16605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSM104443_RS16620	COG0438	transferase activity, transferring glycosyl groups
DSM104443_RS16655	COG1295	ribonuclease BN
DSM104443_RS16680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DSM104443_RS16685	COG3639	organic phosphonate transmembrane transporter activity
DSM104443_RS16690	COG3639	organic phosphonate transmembrane transporter activity
DSM104443_RS16695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DSM104443_RS16700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DSM104443_RS16705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DSM104443_RS16710	COG2205	protein histidine kinase activity
DSM104443_RS16715	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS16725	COG0387	Pfam Sodium calcium exchanger
DSM104443_RS16735	COG2095	MarC family integral membrane protein
DSM104443_RS16745	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS16750	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS16770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DSM104443_RS16775	COG0148	phosphopyruvate hydratase activity
DSM104443_RS16805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104443_RS16900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSM104443_RS16905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DSM104443_RS16910	COG0504	CTP synthase activity
DSM104443_RS16925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
DSM104443_RS16930	COG2943	transferase activity, transferring hexosyl groups
DSM104443_RS16935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS16960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DSM104443_RS16970	COG2897	thiosulfate sulfurtransferase activity
DSM104443_RS17010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104443_RS17040	COG0251	oxidation-reduction process
DSM104443_RS17050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104443_RS17070	COG0166	Belongs to the GPI family
DSM104443_RS17080	COG0598	Magnesium transport protein CorA
DSM104443_RS17100	COG1007	ATP synthesis coupled electron transport
DSM104443_RS17115	COG0713	ATP synthesis coupled electron transport
DSM104443_RS17120	COG0839	Belongs to the complex I subunit 6 family
DSM104443_RS17125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104443_RS17130	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DSM104443_RS17135	COG1034	ATP synthesis coupled electron transport
DSM104443_RS17140	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DSM104443_RS17155	COG0649	NAD binding
DSM104443_RS17160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104443_RS17165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104443_RS17170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104443_RS17185	COG0149	triose-phosphate isomerase activity
DSM104443_RS17205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSM104443_RS17210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM104443_RS17215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104443_RS17220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSM104443_RS17225	COG1534	Rna-binding protein
DSM104443_RS17230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSM104443_RS17235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104443_RS17240	COG0505	Belongs to the CarA family
DSM104443_RS17245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DSM104443_RS17250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM104443_RS17255	COG0735	belongs to the Fur family
DSM104443_RS17280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS17285	COG0783	Belongs to the Dps family
DSM104443_RS17295	COG1741	Belongs to the pirin family
DSM104443_RS17300	COG2259	Doxx family
DSM104443_RS17305	COG1741	Belongs to the pirin family
DSM104443_RS17310	COG0583	DNA-binding transcription factor activity
DSM104443_RS17315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104443_RS17365	COG0473	3-isopropylmalate dehydrogenase activity
DSM104443_RS17370	COG0596	Alpha beta hydrolase
DSM104443_RS17375	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104443_RS17385	COG2815	serine threonine protein kinase
DSM104443_RS17385	COG0515	serine threonine protein kinase
DSM104443_RS17395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSM104443_RS17415	COG1881	PFAM PEBP family protein
DSM104443_RS17420	COG0545	Peptidyl-prolyl cis-trans isomerase
DSM104443_RS17425	COG0405	Gamma-glutamyltransferase
DSM104443_RS17435	COG0747	negative chemotaxis
DSM104443_RS17460	COG0546	phosphoglycolate phosphatase activity
DSM104443_RS17460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSM104443_RS17485	COG0747	negative chemotaxis
DSM104443_RS17505	COG3186	Phenylalanine-4-hydroxylase
DSM104443_RS17515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSM104443_RS17535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM104443_RS17540	COG0747	negative chemotaxis
DSM104443_RS17550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104443_RS17570	COG4608	Belongs to the ABC transporter superfamily
DSM104443_RS17600	COG3706	GGDEF domain
DSM104443_RS17600	COG2203	Gaf domain
DSM104443_RS17600	COG5001	Diguanylate cyclase
DSM104443_RS17600	COG4251	negative regulation of phosphorylation
DSM104443_RS17610	COG1643	Atp-dependent helicase
DSM104443_RS17650	COG0625	glutathione transferase activity
DSM104443_RS17655	COG2084	Dehydrogenase
DSM104443_RS17660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104443_RS17680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DSM104443_RS17700	COG0247	lactate metabolic process
DSM104443_RS17705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DSM104443_RS17715	COG1686	Belongs to the peptidase S11 family
DSM104443_RS17735	COG5265	(ABC) transporter
DSM104443_RS17750	COG3622	Belongs to the hyi family
DSM104443_RS17755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104443_RS17810	COG3383	formate dehydrogenase (NAD+) activity
DSM104443_RS17830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DSM104443_RS17835	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104443_RS17840	COG1733	regulation of RNA biosynthetic process
DSM104443_RS17885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104443_RS17900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS17935	COG0861	Integral membrane protein TerC family
DSM104443_RS17940	COG0741	lytic transglycosylase activity
DSM104443_RS17950	COG0617	tRNA 3'-terminal CCA addition
DSM104443_RS17960	COG2358	TRAP transporter, solute receptor (TAXI family
DSM104443_RS17965	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSM104443_RS17970	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSM104443_RS17985	COG0037	tRNA processing
DSM104443_RS17990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSM104443_RS18000	COG4783	chaperone-mediated protein folding
DSM104443_RS18025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSM104443_RS18030	COG0625	glutathione transferase activity
DSM104443_RS18035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM104443_RS18045	COG1560	Kdo2-lipid A biosynthetic process
DSM104443_RS18050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM104443_RS18060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DSM104443_RS18065	COG0523	cobalamin synthesis protein
DSM104443_RS18070	COG0523	cobalamin synthesis protein
DSM104443_RS18075	COG1136	(ABC) transporter
DSM104443_RS18095	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DSM104443_RS18100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM104443_RS18120	COG3220	belongs to the UPF0276 family
DSM104443_RS18145	COG0071	Belongs to the small heat shock protein (HSP20) family
DSM104443_RS18150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104443_RS18155	COG3568	Endonuclease Exonuclease Phosphatase
DSM104443_RS18165	COG1446	asparaginase
DSM104443_RS18170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DSM104443_RS18190	COG0501	Belongs to the peptidase M48B family
DSM104443_RS18215	COG0629	single-stranded DNA binding
DSM104443_RS18220	COG2814	Major facilitator Superfamily
DSM104443_RS18245	COG0203	ribosomal protein L17
DSM104443_RS18250	COG0202	RNA polymerase activity
DSM104443_RS18255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSM104443_RS18265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSM104443_RS18270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM104443_RS18275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM104443_RS18280	COG0201	protein transport
DSM104443_RS18285	COG0200	Binds to the 23S rRNA
DSM104443_RS18290	COG1841	ribosomal large subunit assembly
DSM104443_RS18295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM104443_RS18300	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM104443_RS18305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM104443_RS18310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM104443_RS18320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM104443_RS18325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM104443_RS18330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM104443_RS18335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM104443_RS18340	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM104443_RS18345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM104443_RS18355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM104443_RS18360	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM104443_RS18365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSM104443_RS18370	COG0089	rRNA binding
DSM104443_RS18375	COG0088	Forms part of the polypeptide exit tunnel
DSM104443_RS18380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM104443_RS18385	COG0051	transcription antitermination factor activity, RNA binding
DSM104443_RS18395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSM104443_RS18400	COG0049	tRNA binding
DSM104443_RS18405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM104443_RS18410	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSM104443_RS18415	COG0085	RNA polymerase activity
DSM104443_RS18420	COG0222	ribosome binding
DSM104443_RS18425	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM104443_RS18430	COG0081	regulation of translation
DSM104443_RS18435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM104443_RS18445	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSM104443_RS18480	COG2969	positive regulation of protein catabolic process
DSM104443_RS18485	COG0625	glutathione transferase activity
DSM104443_RS18490	COG2857	Cytochrome c1
DSM104443_RS18495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104443_RS18500	COG0723	plastoquinol--plastocyanin reductase activity
DSM104443_RS18505	COG1970	mechanosensitive ion channel activity
DSM104443_RS18515	COG0805	protein transport
DSM104443_RS18520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104443_RS18525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104443_RS18535	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM104443_RS18540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM104443_RS18550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSM104443_RS18555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSM104443_RS18560	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM104443_RS18565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DSM104443_RS18570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSM104443_RS18580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DSM104443_RS18585	COG0271	Belongs to the BolA IbaG family
DSM104443_RS18590	COG0842	Transport permease protein
DSM104443_RS18595	COG1131	(ABC) transporter
DSM104443_RS18605	COG2854	intermembrane phospholipid transfer
DSM104443_RS18610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM104443_RS18615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSM104443_RS18620	COG1127	ABC transporter
DSM104443_RS18630	COG3267	Type II secretory pathway component ExeA
DSM104443_RS18630	COG3409	Peptidoglycan-binding domain 1 protein
DSM104443_RS18645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104443_RS18680	COG1469	GTP cyclohydrolase I activity
DSM104443_RS18700	COG1666	GTP binding
DSM104443_RS18715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM104443_RS18720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104443_RS18725	COG0268	Binds directly to 16S ribosomal RNA
DSM104443_RS18735	COG0196	riboflavin kinase activity
DSM104443_RS18740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM104443_RS18745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM104443_RS18750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSM104443_RS18805	COG5487	UPF0391 membrane protein
DSM104443_RS18815	COG0859	PFAM glycosyl transferase family 9
DSM104443_RS18815	COG0457	Tetratricopeptide repeat
DSM104443_RS18820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104443_RS18825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSM104443_RS18830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DSM104443_RS18835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DSM104443_RS18835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104443_RS18840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSM104443_RS18850	COG0754	glutathionylspermidine amidase activity
DSM104443_RS18860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DSM104443_RS18865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DSM104443_RS18870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM104443_RS18880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSM104443_RS18895	COG0126	phosphoglycerate kinase activity
DSM104443_RS18900	COG0469	pyruvate kinase activity
DSM104443_RS18925	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM104443_RS18960	COG1253	flavin adenine dinucleotide binding
DSM104443_RS18965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSM104443_RS18970	COG0730	response to heat
DSM104443_RS19040	COG0859	PFAM glycosyl transferase family 9
DSM104443_RS19050	COG1132	(ABC) transporter
DSM104443_RS19055	COG0297	glycogen (starch) synthase activity
DSM104443_RS19140	COG1450	Type ii and iii secretion system protein
DSM104443_RS19160	COG3156	type II secretion system protein K
DSM104443_RS19170	COG2165	general secretion pathway protein
DSM104443_RS19180	COG2165	general secretion pathway protein
DSM104443_RS19185	COG1459	type II secretion system
DSM104443_RS19190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSM104443_RS19195	COG0004	ammonium transporteR
DSM104443_RS19200	COG0347	Belongs to the P(II) protein family
DSM104443_RS19215	COG0606	chelatase, subunit chli
DSM104443_RS19220	COG2814	Major facilitator Superfamily
DSM104443_RS19245	COG1473	amidohydrolase
DSM104443_RS19250	COG1280	lysine exporter protein (LysE YggA)
DSM104443_RS19285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104443_RS19350	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS19370	COG1902	pentaerythritol trinitrate reductase activity
DSM104443_RS19375	COG0625	glutathione transferase activity
DSM104443_RS19395	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS19405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM104443_RS19410	COG0142	geranyltranstransferase activity
DSM104443_RS19415	COG1722	exodeoxyribonuclease VII activity
DSM104443_RS19515	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS19520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DSM104443_RS19525	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSM104443_RS19540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DSM104443_RS19555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104443_RS19560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DSM104443_RS19605	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DSM104443_RS19630	COG2855	membrane
DSM104443_RS19635	COG2721	sulfolactate sulfo-lyase activity
DSM104443_RS19640	COG2721	sulfolactate sulfo-lyase activity
DSM104443_RS19655	COG2321	neutral zinc metallopeptidase
DSM104443_RS19665	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM104443_RS19670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM104443_RS19675	COG0228	four-way junction DNA binding
DSM104443_RS19695	COG3011	Protein conserved in bacteria
DSM104443_RS19705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM104443_RS19710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM104443_RS19715	COG4536	flavin adenine dinucleotide binding
DSM104443_RS19770	COG3483	tryptophan 2,3-dioxygenase activity
DSM104443_RS19795	COG2885	chlorophyll binding
DSM104443_RS19800	COG2208	phosphoserine phosphatase activity
DSM104443_RS19800	COG2770	Histidine kinase
DSM104443_RS19805	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM104443_RS19815	COG3180	Ammonia monooxygenase
DSM104443_RS19820	COG1609	Transcriptional regulator
DSM104443_RS19840	COG3386	PFAM SMP-30 Gluconolaconase
DSM104443_RS19855	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS19880	COG0642	Histidine kinase
DSM104443_RS19920	COG0714	Associated with various cellular activities
DSM104443_RS19960	COG1942	4-Oxalocrotonate Tautomerase
DSM104443_RS19970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSM104443_RS19985	COG0583	DNA-binding transcription factor activity
DSM104443_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS20025	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS20035	COG2079	MmgE PrpD family protein
DSM104443_RS20065	COG0583	DNA-binding transcription factor activity
DSM104443_RS20100	COG0583	DNA-binding transcription factor activity
DSM104443_RS20110	COG1764	response to oxidative stress
DSM104443_RS20135	COG2197	response regulator
DSM104443_RS20165	COG4575	ribosome binding
DSM104443_RS20180	COG0584	glycerophosphoryl diester phosphodiesterase
DSM104443_RS20200	COG3181	Tripartite tricarboxylate transporter family receptor
DSM104443_RS20220	COG0457	Tetratricopeptide repeat
DSM104443_RS20225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104443_RS20235	COG1741	Belongs to the pirin family
DSM104443_RS20240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104443_RS20245	COG4946	Tricorn protease homolog
DSM104443_RS20245	COG0793	Belongs to the peptidase S41A family
DSM104443_RS20250	COG2205	protein histidine kinase activity
DSM104443_RS20270	COG2951	lytic endotransglycosylase activity
DSM104443_RS20280	COG2081	HI0933 family
DSM104443_RS20290	COG0667	Aldo Keto reductase
DSM104443_RS20300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS20320	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DSM104443_RS20335	COG1131	(ABC) transporter
DSM104443_RS20365	COG0793	Belongs to the peptidase S41A family
DSM104443_RS20385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSM104443_RS20400	COG0459	protein refolding
DSM104443_RS20415	COG2205	protein histidine kinase activity
DSM104443_RS20420	COG2198	Histidine kinase
DSM104443_RS20420	COG2205	protein histidine kinase activity
DSM104443_RS20420	COG0784	Response regulator, receiver
DSM104443_RS20435	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM104443_RS20440	COG1366	Belongs to the anti-sigma-factor antagonist family
DSM104443_RS20445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSM104443_RS20465	COG2027	D-alanyl-D-alanine carboxypeptidase
DSM104443_RS20480	COG1960	acyl-CoA dehydrogenase activity
DSM104443_RS20485	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DSM104443_RS20510	COG4232	protein-disulfide reductase activity
DSM104443_RS20550	COG2945	thiolester hydrolase activity
DSM104443_RS20555	COG3411	Ferredoxin
DSM104443_RS20585	COG2972	Histidine kinase
DSM104443_RS20595	COG3275	phosphorelay sensor kinase activity
DSM104443_RS20605	COG3275	phosphorelay sensor kinase activity
DSM104443_RS20630	COG3842	ATPase activity
DSM104443_RS20640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DSM104443_RS20650	COG0395	ABC-type sugar transport system, permease component
DSM104443_RS20670	COG1506	peptidase
DSM104443_RS20670	COG4946	Tricorn protease homolog
DSM104443_RS20670	COG0823	Involved in the tonB-independent uptake of proteins
DSM104443_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104443_RS20685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSM104443_RS20700	COG0515	serine threonine protein kinase
DSM104443_RS20710	COG2814	Major facilitator Superfamily
DSM104443_RS20730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS20760	COG0745	RESPONSE REGULATOR receiver
DSM104443_RS20765	COG2205	protein histidine kinase activity
DSM104443_RS20775	COG2226	methyltransferase
DSM104443_RS20790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSM104443_RS20795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSM104443_RS20830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS20835	COG2813	Specifically methylates the guanine in position
DSM104443_RS20835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DSM104443_RS20840	COG2223	nitrite transmembrane transporter activity
DSM104443_RS20845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104443_RS20855	COG0488	(ABC) transporter
DSM104443_RS20860	COG0708	Exodeoxyribonuclease III
DSM104443_RS20865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSM104443_RS20875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104443_RS20880	COG0154	amidase activity
DSM104443_RS20885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSM104443_RS20890	COG1077	Cell shape determining protein MreB Mrl
DSM104443_RS20895	COG1792	Involved in formation and maintenance of cell shape
DSM104443_RS20900	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DSM104443_RS20905	COG0768	penicillin binding
DSM104443_RS20910	COG0772	Belongs to the SEDS family
DSM104443_RS20920	COG1686	Belongs to the peptidase S11 family
DSM104443_RS20925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSM104443_RS20930	COG2921	Belongs to the UPF0250 family
DSM104443_RS20935	COG0321	lipoyl(octanoyl) transferase activity
DSM104443_RS20960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSM104443_RS20980	COG3275	phosphorelay sensor kinase activity
DSM104443_RS20985	COG0165	Argininosuccinate lyase
DSM104443_RS20995	COG1965	Belongs to the frataxin family
DSM104443_RS21015	COG2239	Acts as a magnesium transporter
DSM104443_RS21020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSM104443_RS21025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM104443_RS21030	COG0174	glutamine synthetase
DSM104443_RS21040	COG3852	Histidine kinase
DSM104443_RS21045	COG2204	response regulator
DSM104443_RS21065	COG0339	signal peptide processing
DSM104443_RS21075	COG0540	Belongs to the ATCase OTCase family
DSM104443_RS21080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DSM104443_RS21085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSM104443_RS21090	COG1678	Uncharacterized ACR, COG1678
DSM104443_RS21095	COG0415	Belongs to the DNA photolyase family
DSM104443_RS21135	COG3150	esterase
DSM104443_RS21145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSM104443_RS21160	COG0189	ligase activity
DSM104443_RS21185	COG1238	metal cluster binding
DSM104443_RS21190	COG0181	hydroxymethylbilane synthase activity
DSM104443_RS21200	COG2959	enzyme of heme biosynthesis
DSM104443_RS21215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSM104443_RS21230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104443_RS21235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM104443_RS21240	COG0511	ligase activity, forming carbon-carbon bonds
DSM104443_RS21245	COG0439	Biotin carboxylase
DSM104443_RS21250	COG2264	protein methyltransferase activity
DSM104443_RS21265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSM104443_RS21280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DSM104443_RS21285	COG3245	cytochrome
DSM104443_RS21295	COG3307	-O-antigen
DSM104443_RS21310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104443_RS21330	COG0070	glutamate synthase
DSM104443_RS21330	COG0067	glutamate synthase
DSM104443_RS21330	COG0069	glutamate synthase activity
DSM104443_RS21345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DSM104443_RS21350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DSM104443_RS21355	COG0018	arginyl-trna synthetase
DSM104443_RS21370	COG0300	oxidoreductase activity
DSM104443_RS21375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSM104443_RS21385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSM104443_RS21390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSM104443_RS21395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DSM104443_RS21405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DSM104443_RS21430	COG3590	peptidase
DSM104443_RS21440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM104443_RS21450	COG2271	Major facilitator Superfamily
DSM104443_RS21455	COG1404	Belongs to the peptidase S8 family
DSM104443_RS21490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104443_RS21495	COG4597	amino acid ABC transporter
DSM104443_RS21500	COG0765	amino acid transport
DSM104443_RS21505	COG1126	abc transporter atp-binding protein
DSM104443_RS21515	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSM104443_RS21540	COG0583	DNA-binding transcription factor activity
DSM104443_RS21550	COG0477	Major facilitator Superfamily
DSM104443_RS21565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104443_RS21590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSM104443_RS21600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM104443_RS21605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM104443_RS21610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM104443_RS21615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSM104443_RS21620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DSM104443_RS21625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM104443_RS21630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM104443_RS21640	COG0356	it plays a direct role in the translocation of protons across the membrane
DSM104443_RS21650	COG1475	DNA binding
DSM104443_RS21655	COG1192	Involved in chromosome partitioning
DSM104443_RS21660	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM104443_RS21665	COG0445	tRNA wobble uridine modification
DSM104443_RS21680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM104443_RS21685	COG0706	membrane insertase activity
DSM104443_RS21690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM104443_RS21695	COG0594	ribonuclease P activity
DSM104443_RS21700	COG0230	Belongs to the bacterial ribosomal protein bL34 family