locus-tag	class	description
EPR_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPR_RS00010	COG0592	DNA-directed DNA polymerase activity
EPR_RS00015	COG0187	DNA topoisomerase II activity
EPR_RS00020	COG2199	diguanylate cyclase activity
EPR_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPR_RS00060	COG0129	dihydroxy-acid dehydratase activity
EPR_RS00065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPR_RS00070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPR_RS00075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EPR_RS00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPR_RS00095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPR_RS00100	COG0268	Binds directly to 16S ribosomal RNA
EPR_RS00105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPR_RS00115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPR_RS00120	COG0237	dephospho-CoA kinase activity
EPR_RS00125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EPR_RS00135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPR_RS00150	COG1490	D-aminoacyl-tRNA deacylase activity
EPR_RS00170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPR_RS00170	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EPR_RS00175	COG0432	Pfam Uncharacterised protein family UPF0047
EPR_RS00180	COG1187	pseudouridine synthase activity
EPR_RS00185	COG0517	IMP dehydrogenase activity
EPR_RS00185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPR_RS00190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EPR_RS00195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPR_RS00200	COG0107	imidazoleglycerol-phosphate synthase activity
EPR_RS00210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPR_RS00220	COG0564	pseudouridine synthase activity
EPR_RS00225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPR_RS00230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPR_RS00240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EPR_RS00245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPR_RS00260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPR_RS00265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPR_RS00270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPR_RS00275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPR_RS00325	COG0531	amino acid
EPR_RS00330	COG1053	succinate dehydrogenase
EPR_RS00340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPR_RS00350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EPR_RS00355	COG0531	amino acid
EPR_RS00360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPR_RS00365	COG0735	belongs to the Fur family
EPR_RS00380	COG0667	Aldo Keto reductase
EPR_RS00390	COG0348	domain, Protein
EPR_RS00405	COG0504	CTP synthase activity
EPR_RS00410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPR_RS00410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EPR_RS00415	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPR_RS00430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EPR_RS00435	COG3174	membrane
EPR_RS00455	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPR_RS00460	COG0740	serine-type endopeptidase activity
EPR_RS00465	COG0242	peptide deformylase activity
EPR_RS00470	COG0606	chelatase, subunit chli
EPR_RS00475	COG2855	membrane
EPR_RS00480	COG0583	DNA-binding transcription factor activity
EPR_RS00485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPR_RS00485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPR_RS00495	COG2022	thiamine diphosphate biosynthetic process
EPR_RS00500	COG0733	neurotransmitter:sodium symporter activity
EPR_RS00555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EPR_RS00580	COG0310	cobalt ion transport
EPR_RS00590	COG1122	ATPase activity
EPR_RS00610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPR_RS00615	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EPR_RS00620	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EPR_RS00640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EPR_RS00645	COG1981	membrane
EPR_RS00665	COG1269	ATP hydrolysis coupled proton transport
EPR_RS00690	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EPR_RS00705	COG3787	Belongs to the UPF0306 family
EPR_RS00710	COG1238	metal cluster binding
EPR_RS00715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPR_RS00720	COG2895	sulfate adenylyltransferase (ATP) activity
EPR_RS00725	COG0175	sulfate reduction
EPR_RS00730	COG0175	sulfate reduction
EPR_RS00740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPR_RS00755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EPR_RS00760	COG0298	carbon dioxide binding
EPR_RS00765	COG0409	Hydrogenase expression formation protein
EPR_RS00770	COG0309	Hydrogenase expression formation protein (HypE)
EPR_RS00775	COG1024	Enoyl-CoA hydratase
EPR_RS00775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPR_RS00780	COG0375	protein maturation
EPR_RS00805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPR_RS00810	COG0482	sulfurtransferase activity
EPR_RS00815	COG0358	DNA primase activity
EPR_RS00825	COG0328	RNA-DNA hybrid ribonuclease activity
EPR_RS00830	COG0571	ribonuclease III activity
EPR_RS00835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPR_RS00845	COG0579	oxidoreductase
EPR_RS00850	COG0372	Belongs to the citrate synthase family
EPR_RS00855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPR_RS00865	COG0051	transcription antitermination factor activity, RNA binding
EPR_RS00870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPR_RS00875	COG0088	Forms part of the polypeptide exit tunnel
EPR_RS00880	COG0089	rRNA binding
EPR_RS00885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPR_RS00890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPR_RS00895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPR_RS00900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPR_RS00905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPR_RS00910	COG0255	Belongs to the universal ribosomal protein uL29 family
EPR_RS00915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPR_RS00920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPR_RS00925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPR_RS00930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPR_RS00935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPR_RS00940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPR_RS00945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPR_RS00950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPR_RS00955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPR_RS00960	COG0200	Binds to the 23S rRNA
EPR_RS00965	COG0201	protein transport
EPR_RS00970	COG0024	Methionine aminopeptidase
EPR_RS00975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPR_RS00980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPR_RS00985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPR_RS00990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPR_RS00995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPR_RS01000	COG0202	RNA polymerase activity
EPR_RS01005	COG0203	ribosomal protein L17
EPR_RS01020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPR_RS01030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EPR_RS01035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPR_RS01045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPR_RS01055	COG3022	response to hydroperoxide
EPR_RS01080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPR_RS01085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPR_RS01100	COG0250	Participates in transcription elongation, termination and antitermination
EPR_RS01105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPR_RS01110	COG0081	regulation of translation
EPR_RS01115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPR_RS01120	COG0222	ribosome binding
EPR_RS01125	COG0085	RNA polymerase activity
EPR_RS01130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPR_RS01135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPR_RS01140	COG0049	tRNA binding
EPR_RS01145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPR_RS01160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPR_RS01170	COG0724	RNA recognition motif
EPR_RS01175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPR_RS01185	COG3706	GGDEF domain
EPR_RS01225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPR_RS01235	COG0438	transferase activity, transferring glycosyl groups
EPR_RS01245	COG0438	transferase activity, transferring glycosyl groups
EPR_RS01255	COG0367	asparagine synthase
EPR_RS01265	COG0438	transferase activity, transferring glycosyl groups
EPR_RS01270	COG1216	Glycosyl transferase, family 2
EPR_RS01285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPR_RS01290	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EPR_RS01305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPR_RS01315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPR_RS01325	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPR_RS01335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPR_RS01340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPR_RS01345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPR_RS01350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPR_RS01355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPR_RS01360	COG0649	NAD binding
EPR_RS01385	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPR_RS01390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPR_RS01395	COG0839	Belongs to the complex I subunit 6 family
EPR_RS01400	COG0713	ATP synthesis coupled electron transport
EPR_RS01405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPR_RS01415	COG1007	ATP synthesis coupled electron transport
EPR_RS01420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPR_RS01430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPR_RS01435	COG1858	cytochrome C peroxidase
EPR_RS01445	COG0582	viral genome integration into host DNA
EPR_RS01490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EPR_RS01495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPR_RS01500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPR_RS01505	COG0772	Belongs to the SEDS family
EPR_RS01515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPR_RS01525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EPR_RS01530	COG0424	maF-like protein
EPR_RS01535	COG0156	8-amino-7-oxononanoate synthase activity
EPR_RS01540	COG0444	Belongs to the ABC transporter superfamily
EPR_RS01555	COG0174	glutamine synthetase
EPR_RS01560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPR_RS01575	COG0826	peptidase U32
EPR_RS01585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPR_RS01600	COG0752	glycyl-tRNA synthetase alpha subunit
EPR_RS01605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPR_RS01615	COG1519	Transferase
EPR_RS01620	COG1872	DUF167
EPR_RS01625	COG0564	pseudouridine synthase activity
EPR_RS01630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPR_RS01635	COG0228	four-way junction DNA binding
EPR_RS01645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPR_RS01650	COG0336	Belongs to the RNA methyltransferase TrmD family
EPR_RS01655	COG0335	large ribosomal subunit rRNA binding
EPR_RS01665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPR_RS01670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPR_RS01675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPR_RS01695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPR_RS01705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPR_RS01710	COG1862	Preprotein translocase
EPR_RS01715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPR_RS01720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPR_RS01730	COG0495	leucyl-tRNA aminoacylation
EPR_RS01740	COG0285	dihydrofolate synthase activity
EPR_RS01745	COG0739	heme binding
EPR_RS01755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPR_RS01760	COG1692	metallophosphoesterase
EPR_RS01775	COG0488	(ABC) transporter
EPR_RS01780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPR_RS01785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPR_RS01790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPR_RS01805	COG2217	Heavy metal translocating P-type atpase
EPR_RS01815	COG2863	cytochrome
EPR_RS01830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPR_RS01830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPR_RS01835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPR_RS01840	COG0859	PFAM glycosyl transferase family 9
EPR_RS01845	COG0297	glycogen (starch) synthase activity
EPR_RS01860	COG0859	PFAM glycosyl transferase family 9
EPR_RS01865	COG1086	Polysaccharide biosynthesis protein
EPR_RS01870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPR_RS01875	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
EPR_RS01885	COG2089	acid synthase
EPR_RS01920	COG0859	PFAM glycosyl transferase family 9
EPR_RS01935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPR_RS01940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPR_RS01945	COG2264	protein methyltransferase activity
EPR_RS01950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPR_RS01955	COG0688	phosphatidylethanolamine metabolic process
EPR_RS01960	COG1183	phosphatidylcholine synthase activity
EPR_RS01965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPR_RS01975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPR_RS01980	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EPR_RS01990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPR_RS01995	COG1993	acr, cog1993
EPR_RS02000	COG0180	Tryptophanyl-tRNA synthetase
EPR_RS02005	COG1160	GTP binding
EPR_RS02010	COG0668	transmembrane transport
EPR_RS02025	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPR_RS02030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPR_RS02035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPR_RS02040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EPR_RS02045	COG0612	Peptidase, M16
EPR_RS02050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPR_RS02055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPR_RS02080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPR_RS02085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPR_RS02090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPR_RS02095	COG0745	RESPONSE REGULATOR receiver
EPR_RS02100	COG3850	Histidine kinase
EPR_RS02100	COG3437	response regulator, receiver
EPR_RS02100	COG4999	Histidine kinase
EPR_RS02100	COG2205	protein histidine kinase activity
EPR_RS02115	COG0840	transmembrane signaling receptor activity
EPR_RS02120	COG0322	excinuclease ABC activity
EPR_RS02130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPR_RS02135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EPR_RS02140	COG0519	Catalyzes the synthesis of GMP from XMP
EPR_RS02140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPR_RS02160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPR_RS02165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPR_RS02180	COG1185	polyribonucleotide nucleotidyltransferase activity
EPR_RS02185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPR_RS02235	COG0438	transferase activity, transferring glycosyl groups
EPR_RS02255	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPR_RS02260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPR_RS02280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPR_RS02285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPR_RS02295	COG2205	protein histidine kinase activity
EPR_RS02295	COG0784	Response regulator, receiver
EPR_RS02295	COG5002	protein histidine kinase activity
EPR_RS02305	COG0560	Phosphoserine phosphatase
EPR_RS02330	COG1881	PFAM PEBP family protein
EPR_RS02355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPR_RS02375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPR_RS02390	COG1073	alpha beta
EPR_RS02415	COG1649	PFAM Uncharacterised BCR, COG1649
EPR_RS02415	COG0726	polysaccharide deacetylase
EPR_RS02420	COG1215	transferase activity, transferring glycosyl groups
EPR_RS02435	COG3118	belongs to the thioredoxin family
EPR_RS02440	COG2863	cytochrome
EPR_RS02455	COG0642	Histidine kinase
EPR_RS02460	COG0745	RESPONSE REGULATOR receiver
EPR_RS02470	COG1671	Belongs to the UPF0178 family
EPR_RS02485	COG0284	orotidine-5'-phosphate decarboxylase activity
EPR_RS02490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPR_RS02505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPR_RS02520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPR_RS02525	COG3162	membrane
EPR_RS02535	COG0745	RESPONSE REGULATOR receiver
EPR_RS02550	COG0840	transmembrane signaling receptor activity
EPR_RS02555	COG0339	signal peptide processing
EPR_RS02565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPR_RS02570	COG0318	PFAM AMP-dependent synthetase and ligase
EPR_RS02580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPR_RS02590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPR_RS02595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPR_RS02600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPR_RS02605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPR_RS02610	COG1077	Cell shape determining protein MreB Mrl
EPR_RS02620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPR_RS02640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPR_RS02645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPR_RS02660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPR_RS02665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPR_RS02670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPR_RS02675	COG0840	transmembrane signaling receptor activity
EPR_RS02680	COG1410	methionine synthase
EPR_RS02680	COG0646	methionine synthase
EPR_RS02710	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPR_RS02715	COG2199	diguanylate cyclase activity
EPR_RS02715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPR_RS02725	COG0217	transcriptional regulatory protein
EPR_RS02730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPR_RS02735	COG0191	fructose-bisphosphate aldolase activity
EPR_RS02745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPR_RS02755	COG0306	phosphate transporter
EPR_RS02765	COG2814	Major facilitator Superfamily
EPR_RS02780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPR_RS02785	COG0581	inorganic phosphate transmembrane transporter activity
EPR_RS02790	COG0573	inorganic phosphate transmembrane transporter activity
EPR_RS02800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPR_RS02815	COG2205	protein histidine kinase activity
EPR_RS02890	COG2046	Belongs to the sulfate adenylyltransferase family
EPR_RS02900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPR_RS02900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPR_RS02905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPR_RS02910	COG0489	protein tyrosine kinase activity
EPR_RS02925	COG0840	transmembrane signaling receptor activity
EPR_RS02930	COG0840	transmembrane signaling receptor activity
EPR_RS02935	COG0745	RESPONSE REGULATOR receiver
EPR_RS02940	COG0784	Response regulator, receiver
EPR_RS02940	COG0835	chemotaxis
EPR_RS02945	COG0835	chemotaxis
EPR_RS02950	COG0784	Response regulator, receiver
EPR_RS02950	COG0643	Histidine kinase
EPR_RS02950	COG2198	Histidine kinase
EPR_RS02960	COG0840	transmembrane signaling receptor activity
EPR_RS02970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPR_RS02985	COG4786	Flagellar basal body rod
EPR_RS02990	COG4786	Flagellar basal body rod
EPR_RS03005	COG1706	bacterial-type flagellum-dependent cell motility
EPR_RS03015	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPR_RS03020	COG1419	protein localization to endoplasmic reticulum
EPR_RS03025	COG0455	bacterial-type flagellum organization
EPR_RS03030	COG1191	sigma factor activity
EPR_RS03045	COG1815	bacterial-type flagellum-dependent cell motility
EPR_RS03050	COG1558	bacterial-type flagellum-dependent cell motility
EPR_RS03055	COG1677	Flagellar hook-basal body complex protein FliE
EPR_RS03060	COG1766	The M ring may be actively involved in energy transduction
EPR_RS03070	COG1157	protein secretion by the type III secretion system
EPR_RS03080	COG1749	Flagellar hook protein flgE
EPR_RS03085	COG1580	Controls the rotational direction of flagella during chemotaxis
EPR_RS03100	COG1338	Plays a role in the flagellum-specific transport system
EPR_RS03105	COG1987	bacterial-type flagellum assembly
EPR_RS03110	COG1684	flagellar biosynthetic protein fliR
EPR_RS03120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPR_RS03125	COG3706	GGDEF domain
EPR_RS03140	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EPR_RS03155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPR_RS03165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPR_RS03170	COG1516	flagellar protein fliS
EPR_RS03180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPR_RS03185	COG1256	bacterial-type flagellum assembly
EPR_RS03195	COG3706	GGDEF domain
EPR_RS03200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPR_RS03205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPR_RS03210	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EPR_RS03215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPR_RS03220	COG0512	Glutamine amidotransferase of anthranilate synthase
EPR_RS03230	COG0045	succinate-CoA ligase (ADP-forming) activity
EPR_RS03275	COG0165	Argininosuccinate lyase
EPR_RS03280	COG0537	adenosine 5'-monophosphoramidase activity
EPR_RS03285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPR_RS03290	COG0072	phenylalanine-tRNA ligase activity
EPR_RS03290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPR_RS03295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPR_RS03300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPR_RS03305	COG1185	polyribonucleotide nucleotidyltransferase activity
EPR_RS03305	COG0539	negative regulation of cytoplasmic translation
EPR_RS03310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPR_RS03330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPR_RS03340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPR_RS03345	COG0693	protein deglycase activity
EPR_RS03350	COG0561	phosphatase activity
EPR_RS03365	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EPR_RS03365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPR_RS03375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPR_RS03380	COG0587	DNA-directed DNA polymerase activity
EPR_RS03405	COG0772	Belongs to the SEDS family
EPR_RS03410	COG0564	pseudouridine synthase activity
EPR_RS03420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPR_RS03425	COG1136	(ABC) transporter
EPR_RS03440	COG0528	UMP kinase activity
EPR_RS03445	COG1758	RNA polymerase activity
EPR_RS03450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPR_RS03455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPR_RS03465	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPR_RS03475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPR_RS03490	COG0563	adenylate kinase activity
EPR_RS03500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPR_RS03505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPR_RS03510	COG0497	DNA recombination
EPR_RS03515	COG0084	hydrolase, TatD family'
EPR_RS03520	COG0791	NLP P60 protein
EPR_RS03520	COG1388	LysM domain
EPR_RS03525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPR_RS03530	COG0131	Imidazoleglycerol-phosphate dehydratase
EPR_RS03535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPR_RS03550	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPR_RS03570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPR_RS03575	COG0840	transmembrane signaling receptor activity
EPR_RS03575	COG5278	phosphoserine phosphatase activity
EPR_RS03580	COG2201	protein-glutamate methylesterase activity
EPR_RS03585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPR_RS03590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPR_RS03595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPR_RS03600	COG0387	Pfam Sodium calcium exchanger
EPR_RS03610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPR_RS03610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPR_RS03620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPR_RS03645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPR_RS03660	COG0012	GTP binding
EPR_RS03665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPR_RS03670	COG0586	Pfam SNARE associated Golgi protein
EPR_RS03675	COG0133	tryptophan synthase activity
EPR_RS03680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPR_RS03685	COG0698	ribose 5-phosphate isomerase
EPR_RS03690	COG1994	Peptidase M50
EPR_RS03695	COG0681	Belongs to the peptidase S26 family
EPR_RS03700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPR_RS03735	COG3287	FIST C domain
EPR_RS03735	COG2199	diguanylate cyclase activity
EPR_RS03735	COG2200	EAL domain
EPR_RS03745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPR_RS03765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPR_RS03770	COG0066	3-isopropylmalate dehydratase activity
EPR_RS03775	COG0473	3-isopropylmalate dehydrogenase activity
EPR_RS03780	COG0617	tRNA 3'-terminal CCA addition
EPR_RS03785	COG0788	formyltetrahydrofolate deformylase activity
EPR_RS03790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPR_RS03795	COG0751	glycine-tRNA ligase activity
EPR_RS03805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPR_RS03810	COG0166	Belongs to the GPI family
EPR_RS03815	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPR_RS03820	COG1132	(ABC) transporter
EPR_RS03835	COG0189	ligase activity
EPR_RS03865	COG2151	metal-sulfur cluster biosynthetic enzyme
EPR_RS03895	COG0243	molybdopterin cofactor binding
EPR_RS03900	COG0437	4 iron, 4 sulfur cluster binding
EPR_RS03905	COG0348	domain, Protein
EPR_RS03910	COG3043	anaerobic respiration
EPR_RS03955	COG3256	nitric oxide reductase
EPR_RS03965	COG2010	Cytochrome c
EPR_RS03975	COG0535	radical SAM domain protein
EPR_RS03985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPR_RS03985	COG1648	precorrin-2 dehydrogenase activity
EPR_RS03990	COG4263	nitrous-oxide reductase activity
EPR_RS04005	COG0437	4 iron, 4 sulfur cluster binding
EPR_RS04055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPR_RS04055	COG1648	precorrin-2 dehydrogenase activity
EPR_RS04060	COG1522	sequence-specific DNA binding
EPR_RS04100	COG1518	maintenance of DNA repeat elements
EPR_RS04220	COG3621	Patatin-like phospholipase
EPR_RS04250	COG0824	Thioesterase
EPR_RS04260	COG1573	uracil-dna glycosylase
EPR_RS04270	COG2048	Heterodisulfide reductase, subunit B
EPR_RS04285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPR_RS04290	COG0585	pseudouridine synthase activity
EPR_RS04300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPR_RS04305	COG0750	zinc metalloprotease
EPR_RS04310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPR_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
EPR_RS04320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPR_RS04325	COG0612	Peptidase, M16
EPR_RS04330	COG0167	dihydroorotate dehydrogenase activity
EPR_RS04335	COG1132	(ABC) transporter
EPR_RS04340	COG0215	cysteine-tRNA ligase activity
EPR_RS04345	COG0728	peptidoglycan biosynthetic process
EPR_RS04365	COG3287	FIST C domain
EPR_RS04365	COG2200	EAL domain
EPR_RS04365	COG2199	diguanylate cyclase activity
EPR_RS04380	COG3706	GGDEF domain
EPR_RS04385	COG0632	four-way junction helicase activity
EPR_RS04390	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPR_RS04400	COG2081	HI0933 family
EPR_RS04405	COG2860	membrane
EPR_RS04415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPR_RS04415	COG0596	Alpha beta hydrolase
EPR_RS04415	COG2226	methyltransferase
EPR_RS04420	COG1254	Belongs to the acylphosphatase family
EPR_RS04425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPR_RS04460	COG0436	Aminotransferase
EPR_RS04465	COG3001	Fructosamine kinase
EPR_RS04475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPR_RS04480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPR_RS04490	COG0343	queuine tRNA-ribosyltransferase activity
EPR_RS04500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPR_RS04510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPR_RS04515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPR_RS04525	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPR_RS04550	COG0659	secondary active sulfate transmembrane transporter activity
EPR_RS04555	COG0525	valine-tRNA ligase activity
EPR_RS04560	COG0210	DNA helicase
EPR_RS04565	COG1459	type II secretion system
EPR_RS04570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPR_RS04620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPR_RS04625	COG0359	binds to the 23S rRNA
EPR_RS04640	COG0137	argininosuccinate synthase activity
EPR_RS04645	COG0742	ribosomal rna small subunit methyltransferase
EPR_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPR_RS04655	COG2988	succinylglutamate desuccinylase activity
EPR_RS04660	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPR_RS04665	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPR_RS04670	COG0727	PFAM Uncharacterised protein family (UPF0153)
EPR_RS04680	COG0134	indole-3-glycerol-phosphate synthase activity
EPR_RS04710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPR_RS04720	COG1360	Flagellar Motor Protein
EPR_RS04730	COG2217	Heavy metal translocating P-type atpase
EPR_RS04735	COG0745	RESPONSE REGULATOR receiver
EPR_RS04740	COG0642	Histidine kinase
EPR_RS04760	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPR_RS04765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPR_RS04775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EPR_RS04780	COG0077	Prephenate dehydratase
EPR_RS04780	COG1605	Chorismate mutase
EPR_RS04785	COG0582	viral genome integration into host DNA
EPR_RS04790	COG1309	transcriptional regulator
EPR_RS04795	COG1234	tRNA 3'-trailer cleavage
EPR_RS04810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPR_RS04815	COG0789	Transcriptional regulator
EPR_RS04820	COG0484	heat shock protein binding
EPR_RS04830	COG3706	GGDEF domain
EPR_RS04835	COG0326	Molecular chaperone. Has ATPase activity
EPR_RS04840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPR_RS04850	COG0138	bifunctional purine biosynthesis protein purh
EPR_RS04855	COG0205	6-phosphofructokinase activity
EPR_RS04860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPR_RS04865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPR_RS04870	COG0574	Belongs to the PEP-utilizing enzyme family
EPR_RS04870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPR_RS04875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPR_RS04890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPR_RS04900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPR_RS04905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPR_RS04915	COG0706	membrane insertase activity
EPR_RS04920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPR_RS04925	COG0594	ribonuclease P activity
EPR_RS04930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPR_RS04935	COG0439	Biotin carboxylase
EPR_RS04940	COG0542	response to heat
EPR_RS04945	COG0793	Belongs to the peptidase S41A family
EPR_RS04950	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPR_RS04955	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPR_RS04960	COG0047	phosphoribosylformylglycinamidine synthase activity
EPR_RS04970	COG0204	Acyl-transferase
EPR_RS04980	COG4895	conserved protein (DUF2196)
EPR_RS04990	COG1011	Hydrolase
EPR_RS05005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPR_RS05010	COG0492	ferredoxin-NADP+ reductase activity
EPR_RS05020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPR_RS05030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPR_RS05035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPR_RS05050	COG0356	it plays a direct role in the translocation of protons across the membrane
EPR_RS05060	COG1137	ATPase activity
EPR_RS05065	COG0802	atpase or kinase
EPR_RS05070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPR_RS05080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPR_RS05085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPR_RS05090	COG0181	hydroxymethylbilane synthase activity
EPR_RS05100	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPR_RS05105	COG0442	prolyl-tRNA aminoacylation
EPR_RS05110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPR_RS05115	COG0142	geranyltranstransferase activity
EPR_RS05135	COG0275	rRNA processing
EPR_RS05145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPR_RS05155	COG0849	cell division
EPR_RS05160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPR_RS05165	COG1127	ABC transporter
EPR_RS05175	COG2890	protein-(glutamine-N5) methyltransferase activity
EPR_RS05180	COG0501	Belongs to the peptidase M48B family
EPR_RS05185	COG0488	(ABC) transporter
EPR_RS05195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPR_RS05220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPR_RS05225	COG1324	tolerance protein
EPR_RS05230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPR_RS05235	COG1663	tetraacyldisaccharide 4'-kinase activity
EPR_RS05240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPR_RS05245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPR_RS05255	COG2050	protein possibly involved in aromatic compounds catabolism
EPR_RS05255	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EPR_RS05265	COG0500	methyltransferase
EPR_RS05275	COG2824	Alkylphosphonate utilization operon protein PhnA
EPR_RS05285	COG0642	Histidine kinase
EPR_RS05290	COG0745	RESPONSE REGULATOR receiver
EPR_RS05320	COG4221	oxidoreductase activity
EPR_RS05325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPR_RS05330	COG1418	mRNA catabolic process
EPR_RS05340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPR_RS05345	COG0552	protein localization to endoplasmic reticulum
EPR_RS05350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPR_RS05360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPR_RS05365	COG0736	holo-[acyl-carrier-protein] synthase activity
EPR_RS05390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPR_RS05395	COG0243	molybdopterin cofactor binding
EPR_RS05405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPR_RS05415	COG1335	isochorismatase
EPR_RS05420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPR_RS05430	COG0735	belongs to the Fur family
EPR_RS05445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPR_RS05445	COG0574	Belongs to the PEP-utilizing enzyme family
EPR_RS05450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPR_RS05465	COG3962	Belongs to the TPP enzyme family
EPR_RS05470	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPR_RS05470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPR_RS05485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EPR_RS05490	COG0045	succinate-CoA ligase (ADP-forming) activity
EPR_RS05505	COG0039	L-malate dehydrogenase activity
EPR_RS05525	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPR_RS05530	COG0653	protein targeting
EPR_RS05535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPR_RS05540	COG1049	propionate catabolic process, 2-methylcitrate cycle
EPR_RS05545	COG3174	membrane
EPR_RS05550	COG1674	ftsk spoiiie
EPR_RS05550	COG1196	nuclear chromosome segregation
EPR_RS05555	COG4251	negative regulation of phosphorylation
EPR_RS05555	COG3706	GGDEF domain
EPR_RS05555	COG2203	Gaf domain
EPR_RS05555	COG5001	Diguanylate cyclase
EPR_RS05580	COG0348	domain, Protein
EPR_RS05600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPR_RS05605	COG1566	PFAM secretion protein HlyD family protein
EPR_RS05635	COG0019	diaminopimelate decarboxylase activity
EPR_RS05640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPR_RS05655	COG0642	Histidine kinase
EPR_RS05665	COG0776	regulation of translation
EPR_RS05680	COG0163	prenyltransferase activity
EPR_RS05685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPR_RS05695	COG0124	histidyl-tRNA synthetase
EPR_RS05700	COG1166	arginine decarboxylase activity
EPR_RS05705	COG1045	serine acetyltransferase
EPR_RS05720	COG2337	Toxic component of a toxin-antitoxin (TA) module
EPR_RS05730	COG0436	Aminotransferase
EPR_RS05735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPR_RS05745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPR_RS05750	COG0440	acetolactate synthase activity
EPR_RS05755	COG0028	Belongs to the TPP enzyme family
EPR_RS05765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPR_RS05770	COG1832	CoA-binding protein
EPR_RS05775	COG2199	diguanylate cyclase activity
EPR_RS05775	COG2203	Gaf domain
EPR_RS05780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EPR_RS05800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPR_RS05805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPR_RS05810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPR_RS05815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPR_RS05830	COG0101	tRNA pseudouridine synthase activity
EPR_RS05835	COG1355	regulation of microtubule-based process
EPR_RS05840	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPR_RS05860	COG0463	Glycosyl transferase, family 2
EPR_RS05875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EPR_RS05890	COG4232	protein-disulfide reductase activity
EPR_RS05895	COG1331	Highly conserved protein containing a thioredoxin domain
EPR_RS05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPR_RS05905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPR_RS05920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPR_RS05930	COG0443	Heat shock 70 kDa protein
EPR_RS05935	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPR_RS05940	COG1420	regulation of RNA biosynthetic process
EPR_RS05945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPR_RS05950	COG1959	2 iron, 2 sulfur cluster binding
EPR_RS05955	COG2404	hydrolase activity, acting on ester bonds
EPR_RS05965	COG4106	trans-aconitate 2-methyltransferase activity
EPR_RS05970	COG1331	Highly conserved protein containing a thioredoxin domain
EPR_RS05975	COG0196	riboflavin kinase activity
EPR_RS05990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPR_RS06000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EPR_RS06010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPR_RS06015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPR_RS06030	COG0527	aspartate kinase activity
EPR_RS06035	COG0494	nUDIX hydrolase
EPR_RS06040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPR_RS06045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPR_RS06050	COG0805	protein transport
EPR_RS06055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPR_RS06080	COG0038	chloride channel
EPR_RS06085	COG1592	Rubrerythrin
EPR_RS06115	COG4106	trans-aconitate 2-methyltransferase activity
EPR_RS06120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPR_RS06160	COG2252	PERMEase
EPR_RS06165	COG1739	Uncharacterized protein family UPF0029
EPR_RS06175	COG0471	metal ion transport
EPR_RS06180	COG2861	carbohydrate metabolic process
EPR_RS06185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPR_RS06190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPR_RS06195	COG0557	exoribonuclease II activity
EPR_RS06210	COG0360	Binds together with S18 to 16S ribosomal RNA
EPR_RS06215	COG0629	single-stranded DNA binding
EPR_RS06220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPR_RS06230	COG2226	methyltransferase
EPR_RS06235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPR_RS06240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EPR_RS06260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EPR_RS06275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPR_RS06280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPR_RS06290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPR_RS06295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPR_RS06300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EPR_RS06305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPR_RS06310	COG0484	heat shock protein binding
EPR_RS06315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPR_RS06315	COG1333	cytochrome c biogenesis protein
EPR_RS06335	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPR_RS06340	COG0730	response to heat
EPR_RS06350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPR_RS06365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPR_RS06370	COG0352	thiamine-phosphate diphosphorylase activity
EPR_RS06375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPR_RS06385	COG0493	'glutamate synthase
EPR_RS06390	COG0069	glutamate synthase activity
EPR_RS06390	COG0070	glutamate synthase
EPR_RS06390	COG0067	glutamate synthase
EPR_RS06405	COG0517	IMP dehydrogenase activity
EPR_RS06405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPR_RS06410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPR_RS06420	COG3287	FIST C domain
EPR_RS06420	COG2200	EAL domain
EPR_RS06420	COG2199	diguanylate cyclase activity
EPR_RS06425	COG0037	tRNA processing
EPR_RS06430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPR_RS06435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPR_RS06445	COG1047	Peptidyl-prolyl cis-trans
EPR_RS06460	COG0823	Involved in the tonB-independent uptake of proteins
EPR_RS06470	COG0848	biopolymer transport protein
EPR_RS06475	COG0811	peptide transport
EPR_RS06480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPR_RS06485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPR_RS06490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPR_RS06495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPR_RS06500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPR_RS06515	COG1475	DNA binding
EPR_RS06520	COG1192	Involved in chromosome partitioning
EPR_RS06530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPR_RS06535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPR_RS06540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPR_RS06545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPR_RS06550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPR_RS06555	COG0251	oxidation-reduction process
EPR_RS06560	COG1473	amidohydrolase
EPR_RS06565	COG2172	sigma factor antagonist activity
EPR_RS06570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPR_RS06595	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EPR_RS06605	COG0531	amino acid
EPR_RS06610	COG1193	negative regulation of DNA recombination
EPR_RS06630	COG0436	Aminotransferase
EPR_RS06635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPR_RS06640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPR_RS06650	COG1722	exodeoxyribonuclease VII activity
EPR_RS06655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPR_RS06660	COG0517	IMP dehydrogenase activity
EPR_RS06660	COG0516	GMP reductase activity
EPR_RS06665	COG0154	amidase activity
EPR_RS06670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPR_RS06715	COG1067	ATP-dependent peptidase activity
EPR_RS06720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPR_RS06720	COG1796	DNA polymerase
EPR_RS06730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPR_RS06745	COG1111	helicase
EPR_RS06745	COG1205	dead DEAH box helicase
EPR_RS06755	COG4456	Virulence-associated protein
EPR_RS06760	COG1487	ribonuclease activity
EPR_RS06790	COG1397	ADP-ribosylglycohydrolase
EPR_RS06820	COG1401	restriction endodeoxyribonuclease activity
EPR_RS06845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPR_RS06850	COG0459	protein refolding
EPR_RS06870	COG1136	(ABC) transporter
EPR_RS06895	COG0848	biopolymer transport protein
EPR_RS06900	COG0811	peptide transport
EPR_RS06905	COG5002	protein histidine kinase activity
EPR_RS06915	COG0418	dihydroorotase activity
EPR_RS06925	COG0004	ammonium transporteR
EPR_RS06935	COG0004	ammonium transporteR
EPR_RS06940	COG2223	nitrite transmembrane transporter activity
EPR_RS06950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPR_RS06955	COG0243	molybdopterin cofactor binding
EPR_RS06960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPR_RS06970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPR_RS06980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPR_RS06985	COG0731	radical SAM domain protein
EPR_RS07000	COG0840	transmembrane signaling receptor activity
EPR_RS07000	COG3290	protein histidine kinase activity
EPR_RS07015	COG1040	competence protein
EPR_RS07025	COG0481	GTPase activity
EPR_RS07030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPR_RS07035	COG0482	sulfurtransferase activity
EPR_RS07045	COG0455	bacterial-type flagellum organization
EPR_RS07050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPR_RS07055	COG0006	proline dipeptidase activity
EPR_RS07060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPR_RS07065	COG0402	S-adenosylhomocysteine deaminase activity
EPR_RS07070	COG0616	signal peptide processing
EPR_RS07075	COG1570	exodeoxyribonuclease VII activity
EPR_RS07080	COG5016	pyruvate
EPR_RS07080	COG0511	ligase activity, forming carbon-carbon bonds
EPR_RS07105	COG0745	RESPONSE REGULATOR receiver
EPR_RS07110	COG5002	protein histidine kinase activity
EPR_RS07135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPR_RS07160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPR_RS07160	COG1333	cytochrome c biogenesis protein
EPR_RS07200	COG2226	methyltransferase
EPR_RS07205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPR_RS07205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPR_RS07210	COG0779	Required for maturation of 30S ribosomal subunits
EPR_RS07220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPR_RS07230	COG0083	homoserine kinase activity
EPR_RS07240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPR_RS07250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPR_RS07255	COG0157	Belongs to the NadC ModD family
EPR_RS07265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPR_RS07275	COG0745	RESPONSE REGULATOR receiver
EPR_RS07280	COG0642	Histidine kinase
EPR_RS07295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPR_RS07300	COG0287	Prephenate dehydrogenase
EPR_RS07310	COG2304	oxidoreductase activity
EPR_RS07315	COG2304	oxidoreductase activity
EPR_RS07330	COG0714	Associated with various cellular activities
EPR_RS07335	COG0673	inositol 2-dehydrogenase activity
EPR_RS07345	COG3706	GGDEF domain
EPR_RS07375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPR_RS07380	COG0416	fatty acid biosynthetic process
EPR_RS07395	COG0105	UTP biosynthetic process
EPR_RS07400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPR_RS07405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPR_RS07410	COG0450	alkyl hydroperoxide reductase
EPR_RS07420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPR_RS07425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPR_RS07430	COG1605	Chorismate mutase
EPR_RS07430	COG0077	Prephenate dehydratase
EPR_RS07435	COG0647	UMP catabolic process
EPR_RS07440	COG0019	diaminopimelate decarboxylase activity
EPR_RS07450	COG0193	aminoacyl-tRNA hydrolase activity
EPR_RS07455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPR_RS07470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPR_RS07480	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPR_RS07485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPR_RS07495	COG0540	Belongs to the ATCase OTCase family
EPR_RS07500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPR_RS07545	COG3437	response regulator, receiver
EPR_RS07545	COG4999	Histidine kinase
EPR_RS07545	COG3850	Histidine kinase
EPR_RS07545	COG2205	protein histidine kinase activity
EPR_RS07555	COG0745	RESPONSE REGULATOR receiver
EPR_RS07560	COG0745	RESPONSE REGULATOR receiver
EPR_RS07570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPR_RS07590	COG0159	tryptophan synthase activity
EPR_RS07595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPR_RS07600	COG2255	four-way junction helicase activity
EPR_RS07605	COG0628	permease
EPR_RS07610	COG0754	glutathionylspermidine amidase activity
EPR_RS07620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPR_RS07625	COG3338	carbonate dehydratase activity
EPR_RS07630	COG0247	lactate metabolic process
EPR_RS07635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPR_RS07670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPR_RS07675	COG0113	porphobilinogen synthase activity
EPR_RS07680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPR_RS07685	COG0357	Ribosomal RNA small subunit methyltransferase G
EPR_RS07700	COG0501	Belongs to the peptidase M48B family
EPR_RS07705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPR_RS07710	COG2957	Belongs to the agmatine deiminase family
EPR_RS07715	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPR_RS07715	COG3443	Belongs to the bacterial solute-binding protein 9 family
EPR_RS07725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPR_RS07740	COG3706	GGDEF domain
EPR_RS07745	COG2239	Acts as a magnesium transporter
EPR_RS07760	COG0277	FAD linked oxidase domain protein
EPR_RS07765	COG1295	ribonuclease BN
EPR_RS07775	COG0305	Participates in initiation and elongation during chromosome replication
EPR_RS07780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPR_RS07785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPR_RS07800	COG1131	(ABC) transporter
EPR_RS07825	COG0556	nucleotide-excision repair
EPR_RS07835	COG0288	reversible hydration of carbon dioxide
EPR_RS07845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPR_RS07860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPR_RS07880	COG0135	phosphoribosylanthranilate isomerase activity
EPR_RS07885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPR_RS07895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPR_RS07900	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EPR_RS07910	COG0825	malonyl-CoA metabolic process
EPR_RS07915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPR_RS07920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPR_RS07930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPR_RS07935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPR_RS07940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPR_RS07950	COG3706	GGDEF domain
EPR_RS07955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPR_RS07960	COG0037	tRNA processing
EPR_RS07980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPR_RS07990	COG0195	Participates in both transcription termination and antitermination
EPR_RS07995	COG0601	transmembrane transport
EPR_RS08010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPR_RS08015	COG0149	triose-phosphate isomerase activity
EPR_RS08020	COG0126	phosphoglycerate kinase activity
EPR_RS08030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPR_RS08040	COG0018	arginyl-trna synthetase
EPR_RS08045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPR_RS08050	COG0194	GDP metabolic process
EPR_RS08065	COG1136	(ABC) transporter
EPR_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPR_RS08075	COG0052	Belongs to the universal ribosomal protein uS2 family
EPR_RS08080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPR_RS08090	COG1012	belongs to the aldehyde dehydrogenase family
EPR_RS08105	COG0140	phosphoribosyl-ATP diphosphatase activity
EPR_RS08105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPR_RS08110	COG1242	4 iron, 4 sulfur cluster binding
EPR_RS08115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPR_RS08120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPR_RS08125	COG0492	ferredoxin-NADP+ reductase activity
EPR_RS08130	COG3118	belongs to the thioredoxin family
EPR_RS08140	COG3383	formate dehydrogenase (NAD+) activity
EPR_RS08150	COG0460	homoserine dehydrogenase
EPR_RS08155	COG0436	Aminotransferase
EPR_RS08170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPR_RS08180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPR_RS08185	COG0254	rRNA binding
EPR_RS08190	COG1459	type II secretion system
EPR_RS08195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPR_RS08230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPR_RS08240	COG0303	'Molybdopterin
EPR_RS08245	COG2863	cytochrome
EPR_RS08255	COG0602	queuosine metabolic process
EPR_RS08260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPR_RS08270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPR_RS08275	COG0723	plastoquinol--plastocyanin reductase activity
EPR_RS08285	COG0445	tRNA wobble uridine modification
EPR_RS08295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EPR_RS08305	COG2078	PFAM AMMECR1 domain protein
EPR_RS08310	COG3706	GGDEF domain
EPR_RS08330	COG1854	S-ribosylhomocysteine lyase activity
EPR_RS08335	COG1252	NADH dehydrogenase
EPR_RS08340	COG1013	pyruvate-flavodoxin oxidoreductase activity
EPR_RS08345	COG0674	pyruvate-flavodoxin oxidoreductase activity
EPR_RS08350	COG1144	Oxidoreductase
EPR_RS08355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EPR_RS08360	COG0546	phosphoglycolate phosphatase activity
EPR_RS08375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPR_RS08380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPR_RS08385	COG1074	ATP-dependent DNA helicase activity
EPR_RS08405	COG0348	domain, Protein
EPR_RS08430	COG3278	Belongs to the heme-copper respiratory oxidase family
EPR_RS08435	COG0745	RESPONSE REGULATOR receiver
EPR_RS08460	COG0505	Belongs to the CarA family
EPR_RS08470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPR_RS08475	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EPR_RS08480	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPR_RS08485	COG0071	Belongs to the small heat shock protein (HSP20) family
EPR_RS08495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPR_RS08500	COG2814	Major facilitator Superfamily
EPR_RS08510	COG0314	molybdopterin synthase activity
EPR_RS08520	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EPR_RS08525	COG1858	cytochrome C peroxidase
EPR_RS08530	COG3287	FIST C domain
EPR_RS08530	COG2199	diguanylate cyclase activity
EPR_RS08530	COG2200	EAL domain
EPR_RS08540	COG0281	malic enzyme
EPR_RS08540	COG0280	phosphate acetyltransferase
EPR_RS08545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPR_RS08550	COG2171	N-acyltransferase activity
EPR_RS08560	COG0439	Biotin carboxylase
EPR_RS08565	COG0511	ligase activity, forming carbon-carbon bonds
EPR_RS08570	COG0717	Belongs to the dCTP deaminase family
EPR_RS08580	COG0367	asparagine synthase
EPR_RS08595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPR_RS08605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPR_RS08610	COG0569	domain protein
EPR_RS08610	COG0475	glutathione-regulated potassium exporter activity
EPR_RS08625	COG0148	phosphopyruvate hydratase activity
EPR_RS08630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPR_RS08635	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EPR_RS08640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPR_RS08645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EPR_RS08650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPR_RS08660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPR_RS08665	COG0575	Belongs to the CDS family
EPR_RS08670	COG0840	transmembrane signaling receptor activity
EPR_RS08680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPR_RS08685	COG1489	DNA binding
EPR_RS08690	COG0746	molybdenum cofactor guanylyltransferase activity
EPR_RS08705	COG0315	cyclic pyranopterin monophosphate synthase activity
EPR_RS08710	COG0586	Pfam SNARE associated Golgi protein
EPR_RS08730	COG0475	glutathione-regulated potassium exporter activity
EPR_RS08740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EPR_RS08745	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EPR_RS08750	COG0145	ligase activity
EPR_RS08765	COG5002	protein histidine kinase activity
EPR_RS08765	COG5001	Diguanylate cyclase
EPR_RS08775	COG0463	Glycosyl transferase, family 2
EPR_RS08790	COG1215	transferase activity, transferring glycosyl groups
EPR_RS08795	COG2379	hydroxypyruvate reductase
EPR_RS08800	COG3769	mannosylglycerate metabolic process
EPR_RS08805	COG1914	H( )-stimulated, divalent metal cation uptake system
EPR_RS08810	COG0483	inositol monophosphate 1-phosphatase activity
EPR_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPR_RS08820	COG0745	RESPONSE REGULATOR receiver
EPR_RS08825	COG0642	Histidine kinase
EPR_RS08845	COG3300	MHYT domain
EPR_RS08845	COG5001	Diguanylate cyclase
EPR_RS08850	COG1968	undecaprenyl-diphosphatase activity
EPR_RS08865	COG2814	Major facilitator Superfamily
EPR_RS08875	COG1309	transcriptional regulator
EPR_RS08885	COG0569	domain protein
EPR_RS08890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPR_RS08900	COG0842	Transport permease protein
EPR_RS08900	COG1129	ABC transporter
EPR_RS08905	COG0842	Transport permease protein
EPR_RS08910	COG0842	Transport permease protein
EPR_RS08925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EPR_RS08930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPR_RS08935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPR_RS08970	COG1110	DNA topoisomerase II activity
EPR_RS09005	COG1140	nitrate reductase beta subunit
EPR_RS09010	COG0243	molybdopterin cofactor binding
EPR_RS09030	COG0489	protein tyrosine kinase activity
EPR_RS09070	COG0670	Belongs to the BI1 family
EPR_RS09075	COG0352	thiamine-phosphate diphosphorylase activity
EPR_RS09090	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPR_RS09100	COG0233	cytoplasmic translational termination
EPR_RS09105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPR_RS09115	COG2814	Major facilitator Superfamily
EPR_RS09140	COG0778	Nitroreductase
EPR_RS09150	COG1704	LemA family
EPR_RS09155	COG1217	gtp-binding protein TYPA
EPR_RS09160	COG0546	phosphoglycolate phosphatase activity
EPR_RS09165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPR_RS09175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group