locus-tag	class	description
F822_RS00020	COG1764	response to oxidative stress
F822_RS00025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F822_RS00025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F822_RS00035	COG0604	alcohol dehydrogenase
F822_RS00045	COG1696	Membrane protein involved in D-alanine export
F822_RS00095	COG0163	prenyltransferase activity
F822_RS00115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F822_RS00160	COG0523	cobalamin synthesis protein
F822_RS00180	COG0789	Transcriptional regulator
F822_RS00240	COG0668	transmembrane transport
F822_RS00245	COG2873	o-acetylhomoserine
F822_RS00275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
F822_RS00320	COG1538	Outer membrane efflux protein
F822_RS00325	COG1301	dicarboxylic acid transport
F822_RS00330	COG0469	pyruvate kinase activity
F822_RS00345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F822_RS00385	COG0019	diaminopimelate decarboxylase activity
F822_RS00390	COG1971	Probably functions as a manganese efflux pump
F822_RS00410	COG5592	hemerythrin HHE cation binding domain
F822_RS00520	COG1783	phage Terminase large subunit
F822_RS00640	COG1216	Glycosyl transferase, family 2
F822_RS00655	COG3293	Transposase
F822_RS00670	COG3307	-O-antigen
F822_RS00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F822_RS00705	COG2304	oxidoreductase activity
F822_RS00730	COG0469	pyruvate kinase activity
F822_RS00735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F822_RS00740	COG2423	ornithine cyclodeaminase activity
F822_RS00745	COG4264	IucA IucC family
F822_RS00750	COG2814	Major facilitator Superfamily
F822_RS00755	COG4264	IucA IucC family
F822_RS00760	COG4264	IucA IucC family
F822_RS00770	COG0019	diaminopimelate decarboxylase activity
F822_RS00790	COG4774	siderophore transport
F822_RS00800	COG2879	small protein
F822_RS00805	COG1966	Carbon starvation protein
F822_RS00845	COG2094	Belongs to the DNA glycosylase MPG family
F822_RS00875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F822_RS00880	COG1573	uracil-dna glycosylase
F822_RS00890	COG0322	excinuclease ABC activity
F822_RS00940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F822_RS00975	COG1573	uracil-dna glycosylase
F822_RS00980	COG5002	protein histidine kinase activity
F822_RS00980	COG2205	protein histidine kinase activity
F822_RS00980	COG0784	Response regulator, receiver
F822_RS00985	COG0784	Response regulator, receiver
F822_RS00990	COG4251	negative regulation of phosphorylation
F822_RS01000	COG2095	MarC family integral membrane protein
F822_RS01010	COG0322	excinuclease ABC activity
F822_RS01015	COG0776	regulation of translation
F822_RS01030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F822_RS01055	COG1598	PFAM Uncharacterised protein family UPF0150
F822_RS01145	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F822_RS01150	COG1360	Flagellar Motor Protein
F822_RS01175	COG1558	bacterial-type flagellum-dependent cell motility
F822_RS01185	COG1749	Flagellar hook protein flgE
F822_RS01190	COG4787	bacterial-type flagellum-dependent cell motility
F822_RS01200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F822_RS01205	COG1706	bacterial-type flagellum-dependent cell motility
F822_RS01210	COG3951	Flagellar rod assembly protein muramidase FlgJ
F822_RS01210	COG1705	Flagellar rod assembly protein muramidase FlgJ
F822_RS01215	COG1256	bacterial-type flagellum assembly
F822_RS01225	COG0288	reversible hydration of carbon dioxide
F822_RS01235	COG0583	DNA-binding transcription factor activity
F822_RS01240	COG2201	protein-glutamate methylesterase activity
F822_RS01245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F822_RS01250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F822_RS01255	COG0840	transmembrane signaling receptor activity
F822_RS01265	COG2198	Histidine kinase
F822_RS01265	COG0643	Histidine kinase
F822_RS01270	COG0745	RESPONSE REGULATOR receiver
F822_RS01280	COG0745	RESPONSE REGULATOR receiver
F822_RS01310	COG2197	response regulator
F822_RS01345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F822_RS01350	COG5001	Diguanylate cyclase
F822_RS01350	COG5002	protein histidine kinase activity
F822_RS01400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F822_RS01405	COG3190	flagellar
F822_RS01460	COG0436	Aminotransferase
F822_RS01465	COG0556	nucleotide-excision repair
F822_RS01515	COG1309	transcriptional regulator
F822_RS01520	COG1566	PFAM secretion protein HlyD family protein
F822_RS01540	COG0604	alcohol dehydrogenase
F822_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS01540	COG3321	synthase
F822_RS01570	COG1285	pathogenesis
F822_RS01580	COG0318	PFAM AMP-dependent synthetase and ligase
F822_RS01590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F822_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS01615	COG0084	hydrolase, TatD family'
F822_RS01625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F822_RS01635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F822_RS01635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F822_RS01675	COG1643	Atp-dependent helicase
F822_RS01680	COG0676	glucose-6-phosphate 1-epimerase activity
F822_RS01690	COG0110	maltose O-acetyltransferase activity
F822_RS01710	COG1002	Type II restriction enzyme, methylase subunits
F822_RS01715	COG1061	Type III restriction enzyme res subunit
F822_RS01720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F822_RS01735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F822_RS01740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F822_RS01780	COG1199	ATP-dependent helicase activity
F822_RS01805	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F822_RS01840	COG2879	small protein
F822_RS01845	COG1966	Carbon starvation protein
F822_RS01865	COG2205	protein histidine kinase activity
F822_RS01870	COG0745	RESPONSE REGULATOR receiver
F822_RS01915	COG0842	Transport permease protein
F822_RS01920	COG0842	Transport permease protein
F822_RS01925	COG1131	(ABC) transporter
F822_RS01965	COG4772	TonB-dependent receptor
F822_RS01980	COG3145	DNA-N1-methyladenine dioxygenase activity
F822_RS01990	COG2169	Transcriptional regulator
F822_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F822_RS02005	COG1064	alcohol dehydrogenase
F822_RS02015	COG0531	amino acid
F822_RS02025	COG0366	Alpha amylase catalytic
F822_RS02035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F822_RS02040	COG1121	(ABC) transporter
F822_RS02045	COG0803	Belongs to the bacterial solute-binding protein 9 family
F822_RS02055	COG0864	Transcriptional regulator
F822_RS02065	COG3384	dioxygenase
F822_RS02090	COG2910	NAD(P)H-binding
F822_RS02095	COG0783	Belongs to the Dps family
F822_RS02100	COG1473	amidohydrolase
F822_RS02105	COG2860	membrane
F822_RS02110	COG4413	Urea transporter
F822_RS02115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F822_RS02120	COG0830	nickel cation binding
F822_RS02125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F822_RS02130	COG0804	urea catabolic process
F822_RS02135	COG0832	Belongs to the urease beta subunit family
F822_RS02140	COG0831	urea catabolic process
F822_RS02145	COG0829	nickel cation binding
F822_RS02160	COG2197	response regulator
F822_RS02170	COG4681	YaeQ
F822_RS02195	COG1999	signal sequence binding
F822_RS02205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F822_RS02210	COG0148	phosphopyruvate hydratase activity
F822_RS02215	COG0504	CTP synthase activity
F822_RS02220	COG1376	ErfK ybiS ycfS ynhG family protein
F822_RS02225	COG0590	tRNA wobble adenosine to inosine editing
F822_RS02250	COG2918	glutathione biosynthetic process
F822_RS02255	COG1131	(ABC) transporter
F822_RS02260	COG0842	Transport permease protein
F822_RS02285	COG0583	DNA-binding transcription factor activity
F822_RS02300	COG4133	protoheme IX ABC transporter activity
F822_RS02315	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F822_RS02325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F822_RS02335	COG4235	cytochrome complex assembly
F822_RS02340	COG1612	heme a metabolic process
F822_RS02345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F822_RS02350	COG2867	negative regulation of translational initiation
F822_RS02355	COG2914	Belongs to the UPF0125 (RnfH) family
F822_RS02385	COG0519	Catalyzes the synthesis of GMP from XMP
F822_RS02385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F822_RS02455	COG2823	Periplasmic or secreted lipoprotein
F822_RS02460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F822_RS02465	COG0784	Response regulator, receiver
F822_RS02465	COG2205	protein histidine kinase activity
F822_RS02475	COG3240	lipase activity
F822_RS02475	COG4625	pathogenesis
F822_RS02490	COG3459	Glycosyltransferase 36 associated
F822_RS02505	COG2982	Protein involved in outer membrane biogenesis
F822_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS02525	COG1366	Belongs to the anti-sigma-factor antagonist family
F822_RS02525	COG2202	Pas domain
F822_RS02565	COG1132	(ABC) transporter
F822_RS02580	COG1881	PFAM PEBP family protein
F822_RS02590	COG0517	IMP dehydrogenase activity
F822_RS02600	COG0071	Belongs to the small heat shock protein (HSP20) family
F822_RS02645	COG2204	response regulator
F822_RS02655	COG2205	protein histidine kinase activity
F822_RS02665	COG1393	Belongs to the ArsC family
F822_RS02670	COG4651	solute:proton antiporter activity
F822_RS02670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F822_RS02705	COG0493	'glutamate synthase
F822_RS02705	COG0543	2 iron, 2 sulfur cluster binding
F822_RS02710	COG2895	sulfate adenylyltransferase (ATP) activity
F822_RS02720	COG0175	sulfate reduction
F822_RS02725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F822_RS02735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F822_RS02740	COG2850	peptidyl-arginine hydroxylation
F822_RS02785	COG1950	PFAM Membrane protein of
F822_RS02790	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F822_RS02795	COG2226	methyltransferase
F822_RS02800	COG2267	carboxylic ester hydrolase activity
F822_RS02805	COG0156	8-amino-7-oxononanoate synthase activity
F822_RS02810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F822_RS02815	COG1040	competence protein
F822_RS02820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F822_RS02825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F822_RS02835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F822_RS02845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F822_RS02850	COG0588	phosphoglycerate mutase activity
F822_RS02855	COG4942	peptidase
F822_RS02860	COG0793	Belongs to the peptidase S41A family
F822_RS02890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F822_RS02910	COG0583	DNA-binding transcription factor activity
F822_RS02915	COG0326	Molecular chaperone. Has ATPase activity
F822_RS02935	COG1007	ATP synthesis coupled electron transport
F822_RS02950	COG0713	ATP synthesis coupled electron transport
F822_RS02965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS02970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F822_RS02975	COG1034	ATP synthesis coupled electron transport
F822_RS02980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F822_RS02985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F822_RS02990	COG0649	NAD binding
F822_RS02995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03000	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03020	COG0149	triose-phosphate isomerase activity
F822_RS03025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F822_RS03030	COG0581	inorganic phosphate transmembrane transporter activity
F822_RS03035	COG0573	inorganic phosphate transmembrane transporter activity
F822_RS03040	COG3005	denitrification pathway
F822_RS03045	COG0737	Belongs to the 5'-nucleotidase family
F822_RS03055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F822_RS03065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F822_RS03070	COG0045	succinate-CoA ligase (ADP-forming) activity
F822_RS03080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F822_RS03090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F822_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS03100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F822_RS03105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F822_RS03110	COG0416	fatty acid biosynthetic process
F822_RS03125	COG0424	maF-like protein
F822_RS03130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F822_RS03135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F822_RS03135	COG0616	signal peptide processing
F822_RS03150	COG1530	ribonuclease E activity
F822_RS03155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F822_RS03170	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F822_RS03190	COG0312	modulator of DNA gyrase
F822_RS03195	COG1714	RDD family
F822_RS03245	COG1666	GTP binding
F822_RS03250	COG0137	argininosuccinate synthase activity
F822_RS03255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F822_RS03260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F822_RS03265	COG1982	Orn Lys Arg decarboxylase major
F822_RS03275	COG0330	HflC and HflK could
F822_RS03280	COG0268	Binds directly to 16S ribosomal RNA
F822_RS03295	COG0501	Belongs to the peptidase M48B family
F822_RS03300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F822_RS03315	COG2363	Small membrane protein
F822_RS03320	COG1570	exodeoxyribonuclease VII activity
F822_RS03325	COG0811	peptide transport
F822_RS03330	COG0848	biopolymer transport protein
F822_RS03335	COG2835	tetraacyldisaccharide 4'-kinase activity
F822_RS03345	COG0425	Belongs to the sulfur carrier protein TusA family
F822_RS03350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F822_RS03365	COG0494	nUDIX hydrolase
F822_RS03370	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F822_RS03375	COG0723	plastoquinol--plastocyanin reductase activity
F822_RS03380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F822_RS03385	COG2857	Cytochrome c1
F822_RS03390	COG0625	glutathione transferase activity
F822_RS03395	COG2969	positive regulation of protein catabolic process
F822_RS03410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F822_RS03435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F822_RS03445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F822_RS03450	COG5002	protein histidine kinase activity
F822_RS03465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F822_RS03470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F822_RS03485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F822_RS03490	COG3842	ATPase activity
F822_RS03495	COG1176	ABC-type spermidine putrescine transport system, permease component I
F822_RS03500	COG1177	transmembrane transport
F822_RS03515	COG2945	thiolester hydrolase activity
F822_RS03560	COG0517	IMP dehydrogenase activity
F822_RS03590	COG1525	nuclease
F822_RS03595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F822_RS03600	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F822_RS03610	COG0439	Biotin carboxylase
F822_RS03625	COG0531	amino acid
F822_RS03640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F822_RS03650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F822_RS03665	COG0745	RESPONSE REGULATOR receiver
F822_RS03680	COG5654	RES domain protein
F822_RS03725	COG1335	isochorismatase
F822_RS03735	COG0589	response to stress
F822_RS03800	COG1007	ATP synthesis coupled electron transport
F822_RS03815	COG0713	ATP synthesis coupled electron transport
F822_RS03825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F822_RS03850	COG0649	NAD binding
F822_RS03850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03860	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F822_RS03870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F822_RS03875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F822_RS03880	COG0625	glutathione transferase activity
F822_RS03900	COG0488	(ABC) transporter
F822_RS03920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F822_RS03930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F822_RS03935	COG1120	ATPase activity
F822_RS03940	COG0617	tRNA 3'-terminal CCA addition
F822_RS03945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F822_RS03950	COG2255	four-way junction helicase activity
F822_RS03955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F822_RS03960	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F822_RS03970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F822_RS03990	COG2079	MmgE PrpD family protein
F822_RS04010	COG0039	L-malate dehydrogenase activity
F822_RS04020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F822_RS04025	COG1053	succinate dehydrogenase
F822_RS04035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F822_RS04045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F822_RS04050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F822_RS04055	COG0372	Belongs to the citrate synthase family
F822_RS04060	COG0567	Dehydrogenase, E1 component
F822_RS04065	COG0508	dehydrogenase complex catalyzes the overall conversion of
F822_RS04070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F822_RS04075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F822_RS04080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F822_RS04085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F822_RS04090	COG0131	Imidazoleglycerol-phosphate dehydratase
F822_RS04095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F822_RS04100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F822_RS04105	COG0107	imidazoleglycerol-phosphate synthase activity
F822_RS04110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F822_RS04115	COG0140	phosphoribosyl-ATP diphosphatase activity
F822_RS04125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F822_RS04130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F822_RS04140	COG0805	protein transport
F822_RS04145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F822_RS04150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F822_RS04155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F822_RS04165	COG0737	Belongs to the 5'-nucleotidase family
F822_RS04170	COG3005	denitrification pathway
F822_RS04215	COG0203	ribosomal protein L17
F822_RS04220	COG0202	RNA polymerase activity
F822_RS04225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F822_RS04230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F822_RS04235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F822_RS04240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F822_RS04245	COG0201	protein transport
F822_RS04250	COG0200	Binds to the 23S rRNA
F822_RS04255	COG1841	ribosomal large subunit assembly
F822_RS04260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F822_RS04265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F822_RS04270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F822_RS04275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F822_RS04280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F822_RS04285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F822_RS04290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F822_RS04295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F822_RS04300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F822_RS04305	COG0255	Belongs to the universal ribosomal protein uL29 family
F822_RS04310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F822_RS04315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F822_RS04320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F822_RS04325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F822_RS04330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F822_RS04335	COG0089	rRNA binding
F822_RS04340	COG0088	Forms part of the polypeptide exit tunnel
F822_RS04345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F822_RS04350	COG0051	transcription antitermination factor activity, RNA binding
F822_RS04355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F822_RS04360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F822_RS04365	COG0049	tRNA binding
F822_RS04370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F822_RS04380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F822_RS04385	COG0085	RNA polymerase activity
F822_RS04390	COG0222	ribosome binding
F822_RS04395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F822_RS04400	COG0081	regulation of translation
F822_RS04405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F822_RS04415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F822_RS04425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F822_RS04450	COG2832	Protein of unknown function (DUF454)
F822_RS04465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F822_RS04470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F822_RS04485	COG0525	valine-tRNA ligase activity
F822_RS04490	COG0563	adenylate kinase activity
F822_RS04495	COG0205	6-phosphofructokinase activity
F822_RS04500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F822_RS04505	COG3193	protein, possibly involved in utilization of glycolate and propanediol
F822_RS04510	COG0628	permease
F822_RS04515	COG4221	oxidoreductase activity
F822_RS04525	COG0393	Putative heavy-metal-binding
F822_RS04540	COG1178	ABC-type Fe3 transport system permease component
F822_RS04545	COG3842	ATPase activity
F822_RS04555	COG2197	response regulator
F822_RS04560	COG4585	Histidine kinase
F822_RS04565	COG0500	methyltransferase
F822_RS04580	COG2951	lytic endotransglycosylase activity
F822_RS04585	COG1074	ATP-dependent DNA helicase activity
F822_RS04610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F822_RS04620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F822_RS04625	COG0297	glycogen (starch) synthase activity
F822_RS04635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F822_RS04640	COG0501	Belongs to the peptidase M48B family
F822_RS04645	COG2154	pterin-4-alpha-carbinolamine dehydratase
F822_RS04650	COG1162	GTPase activity
F822_RS04660	COG0589	response to stress
F822_RS04700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F822_RS04705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F822_RS04710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F822_RS04715	COG1981	membrane
F822_RS04730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F822_RS04735	COG0719	Fe-S assembly protein
F822_RS04740	COG0396	ATPase activity
F822_RS04745	COG0719	Fe-S assembly protein
F822_RS04790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F822_RS04810	COG4451	ribulose bisphosphate carboxylase, small
F822_RS04820	COG5265	(ABC) transporter
F822_RS04825	COG0688	phosphatidylethanolamine metabolic process
F822_RS04830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F822_RS04850	COG2853	Lipoprotein
F822_RS04855	COG1104	cysteine desulfurase activity
F822_RS04860	COG1959	2 iron, 2 sulfur cluster binding
F822_RS04870	COG0483	inositol monophosphate 1-phosphatase activity
F822_RS04885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F822_RS04895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F822_RS04900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F822_RS04920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F822_RS04925	COG0575	Belongs to the CDS family
F822_RS04930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F822_RS04935	COG0233	cytoplasmic translational termination
F822_RS04940	COG0528	UMP kinase activity
F822_RS04945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F822_RS04950	COG0052	Belongs to the universal ribosomal protein uS2 family
F822_RS04975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F822_RS04980	COG0242	peptide deformylase activity
F822_RS04985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F822_RS04990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F822_RS04995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F822_RS05000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F822_RS05015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F822_RS05025	COG0741	lytic transglycosylase activity
F822_RS05025	COG1388	LysM domain
F822_RS05060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F822_RS05065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F822_RS05080	COG0560	Phosphoserine phosphatase
F822_RS05095	COG1301	dicarboxylic acid transport
F822_RS05100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F822_RS05110	COG1132	(ABC) transporter
F822_RS05120	COG4206	TonB-dependent receptor
F822_RS05170	COG0730	response to heat
F822_RS05175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F822_RS05180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F822_RS05185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F822_RS05195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F822_RS05200	COG0009	L-threonylcarbamoyladenylate synthase
F822_RS05205	COG3568	Endonuclease Exonuclease Phosphatase
F822_RS05210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F822_RS05215	COG0494	nUDIX hydrolase
F822_RS05220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F822_RS05240	COG1858	cytochrome C peroxidase
F822_RS05250	COG0012	GTP binding
F822_RS05255	COG0193	aminoacyl-tRNA hydrolase activity
F822_RS05260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F822_RS05265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F822_RS05275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F822_RS05280	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F822_RS05295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F822_RS05310	COG0762	integral membrane protein
F822_RS05315	COG1872	DUF167
F822_RS05340	COG0335	large ribosomal subunit rRNA binding
F822_RS05345	COG0336	Belongs to the RNA methyltransferase TrmD family
F822_RS05350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F822_RS05355	COG0228	four-way junction DNA binding
F822_RS05360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F822_RS05360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F822_RS05375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F822_RS05385	COG0210	DNA helicase
F822_RS05395	COG3954	Phosphoribulokinase
F822_RS05400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F822_RS05405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F822_RS05410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F822_RS05425	COG0316	Belongs to the HesB IscA family
F822_RS05430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F822_RS05435	COG0739	heme binding
F822_RS05440	COG0784	Response regulator, receiver
F822_RS05440	COG2205	protein histidine kinase activity
F822_RS05445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F822_RS05450	COG0752	glycyl-tRNA synthetase alpha subunit
F822_RS05455	COG0751	glycine-tRNA ligase activity
F822_RS05460	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F822_RS05470	COG1451	nucleotide metabolic process
F822_RS05500	COG4122	O-methyltransferase activity
F822_RS05505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F822_RS05520	COG2239	Acts as a magnesium transporter
F822_RS05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F822_RS05530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F822_RS05540	COG0557	exoribonuclease II activity
F822_RS05550	COG2010	Cytochrome c
F822_RS05570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F822_RS05575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F822_RS05580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F822_RS05585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F822_RS05590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F822_RS05595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F822_RS05595	COG2755	lipolytic protein G-D-S-L family
F822_RS05610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F822_RS05615	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F822_RS05630	COG0495	leucyl-tRNA aminoacylation
F822_RS05640	COG0037	tRNA processing
F822_RS05655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F822_RS05675	COG4208	sulfate ABC transporter
F822_RS05680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F822_RS05715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F822_RS05720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F822_RS05740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F822_RS05745	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F822_RS05760	COG0776	regulation of translation
F822_RS05765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F822_RS05765	COG0072	phenylalanine-tRNA ligase activity
F822_RS05770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F822_RS05775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F822_RS05780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F822_RS05785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F822_RS05790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F822_RS05795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F822_RS05800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F822_RS05805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F822_RS05810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F822_RS05815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F822_RS05820	COG1534	Rna-binding protein
F822_RS05825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F822_RS05830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F822_RS05835	COG0505	Belongs to the CarA family
F822_RS05840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F822_RS05845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F822_RS05850	COG0735	belongs to the Fur family
F822_RS05855	COG0028	Belongs to the TPP enzyme family
F822_RS05860	COG0440	acetolactate synthase activity
F822_RS05865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F822_RS05870	COG1183	phosphatidylcholine synthase activity
F822_RS05875	COG0166	Belongs to the GPI family
F822_RS05880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F822_RS05895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F822_RS05905	COG3338	carbonate dehydratase activity
F822_RS05935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F822_RS05940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F822_RS05975	COG1999	signal sequence binding
F822_RS05980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F822_RS05985	COG1295	ribonuclease BN
F822_RS05985	COG1959	2 iron, 2 sulfur cluster binding
F822_RS05990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F822_RS05995	COG0442	prolyl-tRNA aminoacylation
F822_RS06000	COG0494	nUDIX hydrolase
F822_RS06005	COG1858	cytochrome C peroxidase
F822_RS06015	COG1923	regulation of RNA biosynthetic process
F822_RS06020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F822_RS06025	COG0330	HflC and HflK could
F822_RS06030	COG0330	HflC and HflK could
F822_RS06040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F822_RS06045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F822_RS06070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F822_RS06075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F822_RS06080	COG0704	Plays a role in the regulation of phosphate uptake
F822_RS06085	COG0248	Ppx GppA phosphatase
F822_RS06090	COG0598	Magnesium transport protein CorA
F822_RS06095	COG5212	phosphodiesterase
F822_RS06110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F822_RS06115	COG3836	Belongs to the HpcH HpaI aldolase family
F822_RS06125	COG0702	epimerase
F822_RS06135	COG1213	nucleotidyl transferase
F822_RS06155	COG0588	phosphoglycerate mutase activity
F822_RS06160	COG0463	Glycosyl transferase, family 2
F822_RS06190	COG1083	cytidylyl-transferase
F822_RS06220	COG2089	acid synthase
F822_RS06225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F822_RS06245	COG0795	lipopolysaccharide-transporting ATPase activity
F822_RS06250	COG0795	lipopolysaccharide-transporting ATPase activity
F822_RS06260	COG0456	acetyltransferase
F822_RS06270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F822_RS06275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F822_RS06285	COG0758	DNA mediated transformation
F822_RS06290	COG0242	peptide deformylase activity
F822_RS06295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F822_RS06300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F822_RS06300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F822_RS06310	COG5000	phosphorelay sensor kinase activity
F822_RS06315	COG2204	response regulator
F822_RS06320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F822_RS06325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F822_RS06330	COG0126	phosphoglycerate kinase activity
F822_RS06335	COG0469	pyruvate kinase activity
F822_RS06350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F822_RS06355	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
F822_RS06360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F822_RS06360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F822_RS06365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F822_RS06425	COG1136	(ABC) transporter
F822_RS06440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F822_RS06460	COG0424	maF-like protein
F822_RS06465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F822_RS06470	COG0799	negative regulation of ribosome biogenesis
F822_RS06475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F822_RS06480	COG0508	dehydrogenase complex catalyzes the overall conversion of
F822_RS06485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F822_RS06490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F822_RS06505	COG0418	dihydroorotase activity
F822_RS06510	COG0514	ATP-dependent DNA helicase (RecQ)
F822_RS06535	COG3158	transport of potassium into the cell
F822_RS06555	COG1742	UPF0060 membrane protein
F822_RS06565	COG2226	methyltransferase
F822_RS06570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F822_RS06575	COG0129	dihydroxy-acid dehydratase activity
F822_RS06580	COG1331	Highly conserved protein containing a thioredoxin domain
F822_RS06585	COG4654	Cytochrome c, class I
F822_RS06600	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F822_RS06605	COG0247	lactate metabolic process
F822_RS06610	COG2119	membrane
F822_RS06615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F822_RS06615	COG0517	IMP dehydrogenase activity
F822_RS06630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F822_RS06635	COG0154	amidase activity
F822_RS06640	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F822_RS06645	COG1077	Cell shape determining protein MreB Mrl
F822_RS06650	COG1792	Involved in formation and maintenance of cell shape
F822_RS06660	COG0768	penicillin binding
F822_RS06665	COG0772	Belongs to the SEDS family
F822_RS06685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F822_RS06690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F822_RS06695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F822_RS06700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F822_RS06705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F822_RS06715	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F822_RS06720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F822_RS06725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F822_RS06730	COG0513	Belongs to the DEAD box helicase family
F822_RS06735	COG2081	HI0933 family
F822_RS06750	COG3220	belongs to the UPF0276 family
F822_RS06765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F822_RS06770	COG1185	polyribonucleotide nucleotidyltransferase activity
F822_RS06775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F822_RS06785	COG1657	PFAM Prenyltransferase squalene oxidase
F822_RS06790	COG2853	Lipoprotein
F822_RS06805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F822_RS06810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F822_RS06815	COG0134	indole-3-glycerol-phosphate synthase activity
F822_RS06820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F822_RS06855	COG0811	peptide transport
F822_RS06910	COG1450	Type ii and iii secretion system protein
F822_RS06940	COG1459	type II secretion system
F822_RS06950	COG5039	Polysaccharide pyruvyl transferase
F822_RS06960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F822_RS06975	COG0587	DNA-directed DNA polymerase activity
F822_RS07060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F822_RS07065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F822_RS07080	COG0189	ligase activity
F822_RS07090	COG0542	response to heat
F822_RS07095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F822_RS07100	COG0509	glycine decarboxylation via glycine cleavage system
F822_RS07105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F822_RS07110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F822_RS07115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F822_RS07120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F822_RS07130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F822_RS07145	COG3158	transport of potassium into the cell
F822_RS07155	COG2062	phosphohistidine phosphatase, SixA
F822_RS07165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F822_RS07170	COG0792	nuclease activity
F822_RS07175	COG2823	Periplasmic or secreted lipoprotein
F822_RS07180	COG0277	FAD linked oxidase domain protein
F822_RS07185	COG1999	signal sequence binding
F822_RS07190	COG0109	protoheme IX farnesyltransferase activity
F822_RS07220	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
F822_RS07225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F822_RS07245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F822_RS07250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F822_RS07255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F822_RS07265	COG1674	ftsk spoiiie
F822_RS07270	COG0247	lactate metabolic process
F822_RS07275	COG0277	FAD linked oxidase domain protein
F822_RS07280	COG0277	FAD linked oxidase domain protein
F822_RS07285	COG2084	Dehydrogenase
F822_RS07290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F822_RS07315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F822_RS07355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F822_RS07390	COG0385	Bile acid
F822_RS07425	COG0408	coproporphyrinogen oxidase activity
F822_RS07430	COG0151	Belongs to the GarS family
F822_RS07435	COG0138	bifunctional purine biosynthesis protein purh
F822_RS07450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F822_RS07460	COG0006	proline dipeptidase activity
F822_RS07475	COG2960	long-chain fatty acid transporting porin activity
F822_RS07480	COG0606	chelatase, subunit chli
F822_RS07520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F822_RS07525	COG1758	RNA polymerase activity
F822_RS07530	COG0194	GDP metabolic process
F822_RS07540	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS07550	COG1335	isochorismatase
F822_RS07560	COG1561	YicC-like family, N-terminal region
F822_RS07565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F822_RS07570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F822_RS07575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F822_RS07580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F822_RS07585	COG2022	thiamine diphosphate biosynthetic process
F822_RS07615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F822_RS07620	COG1660	Displays ATPase and GTPase activities
F822_RS07625	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F822_RS07635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F822_RS07640	COG1137	ATPase activity
F822_RS07645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F822_RS07655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F822_RS07660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F822_RS07670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F822_RS07675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F822_RS07685	COG1960	acyl-CoA dehydrogenase activity
F822_RS07690	COG1022	Amp-dependent synthetase and ligase
F822_RS07695	COG1607	acyl-coa hydrolase
F822_RS07705	COG1024	Enoyl-CoA hydratase
F822_RS07705	COG1250	3-hydroxyacyl-CoA dehydrogenase
F822_RS07710	COG0183	Belongs to the thiolase family
F822_RS07720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F822_RS07750	COG4572	Cation transport regulator
F822_RS07780	COG2067	long-chain fatty acid transport protein
F822_RS07805	COG1943	Transposase
F822_RS07810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F822_RS07820	COG2840	Smr protein MutS2
F822_RS07825	COG0492	ferredoxin-NADP+ reductase activity
F822_RS07830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F822_RS07840	COG2137	regulation of response to DNA damage stimulus
F822_RS07845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F822_RS07860	COG1546	Belongs to the CinA family
F822_RS07865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F822_RS07870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F822_RS07875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F822_RS07880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F822_RS07900	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F822_RS07905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F822_RS07905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F822_RS07910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F822_RS07915	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F822_RS07925	COG0592	DNA-directed DNA polymerase activity
F822_RS07930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F822_RS07935	COG0594	ribonuclease P activity
F822_RS07940	COG0706	membrane insertase activity
F822_RS07945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F822_RS07950	COG0445	tRNA wobble uridine modification
F822_RS07955	COG0357	Ribosomal RNA small subunit methyltransferase G
F822_RS07960	COG1192	Involved in chromosome partitioning
F822_RS07965	COG1475	DNA binding
F822_RS08025	COG3293	Transposase
F822_RS08060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F822_RS08065	COG0511	ligase activity, forming carbon-carbon bonds
F822_RS08070	COG0439	Biotin carboxylase
F822_RS08075	COG2264	protein methyltransferase activity
F822_RS08085	COG1127	ABC transporter
F822_RS08090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F822_RS08095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F822_RS08110	COG1131	(ABC) transporter
F822_RS08115	COG0842	Transport permease protein
F822_RS08120	COG0271	Belongs to the BolA IbaG family
F822_RS08125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F822_RS08130	COG2177	Part of the ABC transporter FtsEX involved in
F822_RS08135	COG2884	Cell division ATP-binding protein ftsE
F822_RS08145	COG0612	Peptidase, M16
F822_RS08150	COG0612	Peptidase, M16
F822_RS08155	COG0742	ribosomal rna small subunit methyltransferase
F822_RS08160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F822_RS08165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F822_RS08175	COG1487	ribonuclease activity
F822_RS08195	COG0429	hydrolase of the alpha beta-hydrolase fold
F822_RS08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F822_RS08270	COG0217	transcriptional regulatory protein
F822_RS08275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F822_RS08280	COG0632	four-way junction helicase activity
F822_RS08285	COG2255	four-way junction helicase activity
F822_RS08290	COG0824	Thioesterase
F822_RS08310	COG0823	Involved in the tonB-independent uptake of proteins
F822_RS08325	COG0602	queuosine metabolic process
F822_RS08330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F822_RS08335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F822_RS08340	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F822_RS08350	COG0167	dihydroorotate dehydrogenase activity
F822_RS08355	COG2878	Part of a membrane complex involved in electron transport
F822_RS08360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F822_RS08380	COG0488	(ABC) transporter
F822_RS08395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F822_RS08400	COG1702	phosphate starvation-inducible protein PhoH
F822_RS08405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F822_RS08410	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F822_RS08415	COG0181	hydroxymethylbilane synthase activity
F822_RS08445	COG1324	tolerance protein
F822_RS08450	COG4232	protein-disulfide reductase activity
F822_RS08455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F822_RS08460	COG0730	response to heat
F822_RS08485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F822_RS08495	COG2197	response regulator
F822_RS08500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F822_RS08515	COG2204	response regulator
F822_RS08545	COG2226	methyltransferase
F822_RS08555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F822_RS08560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F822_RS08565	COG0573	inorganic phosphate transmembrane transporter activity
F822_RS08570	COG0573	inorganic phosphate transmembrane transporter activity
F822_RS08575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F822_RS08590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F822_RS08605	COG2116	formate transmembrane transporter activity
F822_RS08610	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F822_RS08620	COG0737	Belongs to the 5'-nucleotidase family
F822_RS08625	COG3005	denitrification pathway
F822_RS08635	COG0513	Belongs to the DEAD box helicase family
F822_RS08640	COG2096	Adenosyltransferase
F822_RS08645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F822_RS08650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F822_RS08655	COG0196	riboflavin kinase activity
F822_RS08665	COG2336	PFAM SpoVT AbrB
F822_RS08700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F822_RS08705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F822_RS08715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F822_RS08720	COG1238	metal cluster binding
F822_RS08725	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
F822_RS08730	COG0583	DNA-binding transcription factor activity
F822_RS08735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F822_RS08765	COG2076	Multidrug Resistance protein
F822_RS08775	COG2827	Endonuclease containing a URI domain
F822_RS08825	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F822_RS08830	COG0024	Methionine aminopeptidase
F822_RS08845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F822_RS08850	COG0352	thiamine-phosphate diphosphorylase activity
F822_RS08860	COG1773	rubredoxin
F822_RS08890	COG0668	transmembrane transport
F822_RS08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F822_RS08900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F822_RS08900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F822_RS08910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F822_RS08915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F822_RS08930	COG4139	cobalamin transport
F822_RS08950	COG3161	chorismate lyase activity
F822_RS08955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F822_RS08960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F822_RS08965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F822_RS08970	COG2211	Major facilitator Superfamily
F822_RS08975	COG0708	Exodeoxyribonuclease III
F822_RS08980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F822_RS09005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F822_RS09015	COG0318	PFAM AMP-dependent synthetase and ligase
F822_RS09030	COG1722	exodeoxyribonuclease VII activity
F822_RS09035	COG0142	geranyltranstransferase activity
F822_RS09040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F822_RS09045	COG1469	GTP cyclohydrolase I activity
F822_RS09070	COG2197	response regulator
F822_RS09075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F822_RS09100	COG0489	protein tyrosine kinase activity
F822_RS09155	COG0297	glycogen (starch) synthase activity
F822_RS09155	COG0438	transferase activity, transferring glycosyl groups
F822_RS09185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F822_RS09205	COG1187	pseudouridine synthase activity
F822_RS09215	COG1091	dTDP-4-dehydrorhamnose reductase activity
F822_RS09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F822_RS09275	COG0463	Glycosyl transferase, family 2
F822_RS09305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F822_RS09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F822_RS09340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F822_RS09350	COG0438	transferase activity, transferring glycosyl groups
F822_RS09360	COG2755	lipolytic protein G-D-S-L family
F822_RS09360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F822_RS09400	COG1216	Glycosyl transferase, family 2
F822_RS09410	COG0529	Catalyzes the synthesis of activated sulfate
F822_RS09425	COG0500	methyltransferase
F822_RS09425	COG3615	Tellurite resistance protein tehB
F822_RS09435	COG0356	it plays a direct role in the translocation of protons across the membrane
F822_RS09445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F822_RS09450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F822_RS09455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F822_RS09460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F822_RS09465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F822_RS09470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F822_RS09475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F822_RS09505	COG4783	chaperone-mediated protein folding
F822_RS09510	COG0347	Belongs to the P(II) protein family
F822_RS09525	COG0463	Glycosyl transferase, family 2
F822_RS09530	COG1051	belongs to the nudix hydrolase family
F822_RS09530	COG1056	cytidyltransferase-related domain
F822_RS09535	COG1136	(ABC) transporter
F822_RS09535	COG0577	efflux transmembrane transporter activity
F822_RS09545	COG1136	(ABC) transporter
F822_RS09550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F822_RS09555	COG0860	N-Acetylmuramoyl-L-alanine amidase
F822_RS09560	COG0802	atpase or kinase
F822_RS09570	COG1596	polysaccharide export
F822_RS09585	COG0489	protein tyrosine kinase activity
F822_RS09595	COG3409	Peptidoglycan-binding domain 1 protein
F822_RS09595	COG3267	Type II secretory pathway component ExeA
F822_RS09620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F822_RS09620	COG0438	transferase activity, transferring glycosyl groups
F822_RS09625	COG0367	asparagine synthase
F822_RS09680	COG1136	(ABC) transporter
F822_RS09720	COG0658	competence protein
F822_RS09720	COG2333	competence protein COMEC
F822_RS09725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F822_RS09730	COG2001	Belongs to the MraZ family
F822_RS09735	COG0275	rRNA processing
F822_RS09750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F822_RS09755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F822_RS09760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F822_RS09765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F822_RS09770	COG0772	Belongs to the SEDS family
F822_RS09775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F822_RS09780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F822_RS09785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F822_RS09790	COG1181	Belongs to the D-alanine--D-alanine ligase family
F822_RS09795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F822_RS09815	COG0739	heme binding
F822_RS09820	COG0653	protein targeting
F822_RS09830	COG0339	signal peptide processing
F822_RS09835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F822_RS09840	COG0540	Belongs to the ATCase OTCase family
F822_RS09845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F822_RS09850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F822_RS09855	COG1678	Uncharacterized ACR, COG1678
F822_RS09880	COG0861	Integral membrane protein TerC family
F822_RS09890	COG0114	fumarate hydratase activity
F822_RS09905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F822_RS09910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F822_RS09910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F822_RS09925	COG0018	arginyl-trna synthetase
F822_RS09935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F822_RS09940	COG0300	oxidoreductase activity
F822_RS09945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F822_RS09950	COG0617	tRNA 3'-terminal CCA addition
F822_RS09960	COG0741	lytic transglycosylase activity
F822_RS09965	COG1012	belongs to the aldehyde dehydrogenase family
F822_RS09970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F822_RS09975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F822_RS09985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F822_RS10020	COG1285	pathogenesis
F822_RS10025	COG2823	Periplasmic or secreted lipoprotein
F822_RS10040	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F822_RS10060	COG0644	oxidoreductase
F822_RS10085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F822_RS10090	COG0343	queuine tRNA-ribosyltransferase activity
F822_RS10095	COG1862	Preprotein translocase
F822_RS10100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F822_RS10105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F822_RS10110	COG0586	Pfam SNARE associated Golgi protein
F822_RS10115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F822_RS10120	COG1420	regulation of RNA biosynthetic process
F822_RS10125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F822_RS10130	COG0497	DNA recombination
F822_RS10135	COG0708	Exodeoxyribonuclease III
F822_RS10140	COG0302	gtp cyclohydrolase
F822_RS10160	COG0312	modulator of DNA gyrase
F822_RS10165	COG3028	Belongs to the UPF0307 family
F822_RS10170	COG1305	Transglutaminase-like
F822_RS10175	COG0400	carboxylic ester hydrolase activity
F822_RS10180	COG0745	RESPONSE REGULATOR receiver
F822_RS10185	COG5002	protein histidine kinase activity
F822_RS10185	COG3850	Histidine kinase
F822_RS10200	COG1215	transferase activity, transferring glycosyl groups
F822_RS10205	COG3609	addiction module antidote protein, CC2985 family
F822_RS10215	COG0730	response to heat
F822_RS10225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F822_RS10230	COG1216	Glycosyl transferase, family 2
F822_RS10260	COG4256	Hemin uptake protein
F822_RS10320	COG0450	alkyl hydroperoxide reductase
F822_RS10350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F822_RS10350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F822_RS10355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F822_RS10355	COG0047	phosphoribosylformylglycinamidine synthase activity
F822_RS10405	COG0105	UTP biosynthetic process
F822_RS10410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F822_RS10420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F822_RS10425	COG0124	histidyl-tRNA synthetase
F822_RS10430	COG2976	Protein conserved in bacteria
F822_RS10435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F822_RS10440	COG1160	GTP binding
F822_RS10445	COG2967	ApaG domain
F822_RS10450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F822_RS10455	COG0546	phosphoglycolate phosphatase activity
F822_RS10480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F822_RS10485	COG0459	protein refolding
F822_RS10495	COG1028	Short-chain dehydrogenase reductase Sdr
F822_RS10505	COG0544	peptidyl-prolyl cis-trans isomerase activity
F822_RS10510	COG0740	serine-type endopeptidase activity
F822_RS10515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F822_RS10520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F822_RS10540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F822_RS10565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F822_RS10575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F822_RS10580	COG3001	Fructosamine kinase
F822_RS10585	COG0165	Argininosuccinate lyase
F822_RS10590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F822_RS10635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F822_RS10640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F822_RS10645	COG0180	Tryptophanyl-tRNA synthetase
F822_RS10650	COG1994	Peptidase M50
F822_RS10655	COG0009	L-threonylcarbamoyladenylate synthase
F822_RS10660	COG0613	PHP domain protein
F822_RS10670	COG1648	precorrin-2 dehydrogenase activity
F822_RS10670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F822_RS10675	COG1943	Transposase
F822_RS10685	COG0450	alkyl hydroperoxide reductase
F822_RS10690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F822_RS10700	COG3039	Transposase
F822_RS10705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F822_RS10710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F822_RS10765	COG2345	Transcriptional regulator
F822_RS10775	COG5002	protein histidine kinase activity
F822_RS10775	COG0784	Response regulator, receiver
F822_RS10775	COG2205	protein histidine kinase activity
F822_RS10790	COG0848	biopolymer transport protein
F822_RS10795	COG0811	peptide transport
F822_RS10800	COG4251	negative regulation of phosphorylation
F822_RS10805	COG0784	Response regulator, receiver
F822_RS10835	COG0174	glutamine synthetase
F822_RS10845	COG1968	undecaprenyl-diphosphatase activity
F822_RS10850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F822_RS10855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F822_RS10865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F822_RS10870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F822_RS10880	COG2010	Cytochrome c
F822_RS10880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F822_RS10890	COG1937	Protein conserved in bacteria
F822_RS10900	COG2217	Heavy metal translocating P-type atpase
F822_RS10910	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F822_RS10920	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F822_RS10925	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F822_RS10945	COG2226	methyltransferase
F822_RS10955	COG0438	transferase activity, transferring glycosyl groups
F822_RS10960	COG0438	transferase activity, transferring glycosyl groups
F822_RS10990	COG0596	Alpha beta hydrolase
F822_RS11000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F822_RS11005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F822_RS11015	COG1132	(ABC) transporter
F822_RS11025	COG0189	ligase activity
F822_RS11025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F822_RS11030	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F822_RS11030	COG1181	Belongs to the D-alanine--D-alanine ligase family
F822_RS11035	COG3360	Dodecin
F822_RS11040	COG0542	response to heat
F822_RS11045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F822_RS11050	COG1278	Cold shock
F822_RS11070	COG0482	sulfurtransferase activity
F822_RS11075	COG0625	glutathione transferase activity
F822_RS11085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F822_RS11090	COG0443	Heat shock 70 kDa protein
F822_RS11095	COG0484	heat shock protein binding
F822_RS11110	COG3012	SEC-C Motif Domain Protein
F822_RS11150	COG2814	Major facilitator Superfamily
F822_RS11155	COG0629	single-stranded DNA binding
F822_RS11205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F822_RS11210	COG0670	Belongs to the BI1 family
F822_RS11265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F822_RS11275	COG0287	Prephenate dehydrogenase
F822_RS11280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F822_RS11285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F822_RS11295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F822_RS11300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F822_RS11315	COG0402	S-adenosylhomocysteine deaminase activity
F822_RS11320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F822_RS11325	COG0546	phosphoglycolate phosphatase activity
F822_RS11360	COG2801	Transposase and inactivated derivatives
F822_RS11400	COG2738	Putative neutral zinc metallopeptidase
F822_RS11415	COG1446	asparaginase
F822_RS11425	COG1136	(ABC) transporter
F822_RS11430	COG1566	PFAM secretion protein HlyD family protein
F822_RS11480	COG2855	membrane
F822_RS11540	COG1063	alcohol dehydrogenase
F822_RS11560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F822_RS11575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F822_RS11580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F822_RS11585	COG2003	Belongs to the UPF0758 family
F822_RS11595	COG0756	dUTP diphosphatase activity
F822_RS11605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F822_RS11610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F822_RS11615	COG4536	flavin adenine dinucleotide binding
F822_RS11625	COG0237	dephospho-CoA kinase activity
F822_RS11630	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
F822_RS11635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F822_RS11640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F822_RS11645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F822_RS11655	COG1214	PFAM Peptidase M22, glycoprotease
F822_RS11660	COG0456	acetyltransferase
F822_RS11665	COG1573	uracil-dna glycosylase
F822_RS11670	COG1704	LemA family
F822_RS11675	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F822_RS11685	COG0477	Major facilitator Superfamily
F822_RS11690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F822_RS11695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F822_RS11705	COG2350	Protein conserved in bacteria
F822_RS11710	COG2917	probably involved in intracellular septation
F822_RS11715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F822_RS11785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F822_RS11800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F822_RS11805	COG1073	alpha beta
F822_RS11810	COG0584	glycerophosphoryl diester phosphodiesterase
F822_RS11820	COG0254	rRNA binding
F822_RS11825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F822_RS11840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F822_RS11850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F822_RS11855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F822_RS11880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F822_RS11895	COG1045	serine acetyltransferase
F822_RS11900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F822_RS11905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F822_RS11910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F822_RS11920	COG0776	regulation of translation
F822_RS11930	COG0284	orotidine-5'-phosphate decarboxylase activity
F822_RS11940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F822_RS11945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F822_RS11950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F822_RS11955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F822_RS12190	COG1598	PFAM Uncharacterised protein family UPF0150
F822_RS12215	COG1475	DNA binding
F822_RS12280	COG4783	chaperone-mediated protein folding
F822_RS12365	COG0631	protein serine/threonine phosphatase activity
F822_RS12370	COG0045	succinate-CoA ligase (ADP-forming) activity
F822_RS12375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F822_RS12380	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F822_RS12385	COG0433	COG0433 Predicted ATPase
F822_RS12395	COG1686	Belongs to the peptidase S11 family
F822_RS12405	COG2921	Belongs to the UPF0250 family
F822_RS12410	COG0321	lipoyl(octanoyl) transferase activity
F822_RS12415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F822_RS12435	COG1127	ABC transporter
F822_RS12440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F822_RS12450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F822_RS12465	COG0564	pseudouridine synthase activity
F822_RS12475	COG0589	response to stress
F822_RS12485	COG4181	ATPase activity
F822_RS12525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F822_RS12560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F822_RS12560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F822_RS12565	COG0489	protein tyrosine kinase activity
F822_RS12570	COG0717	Belongs to the dCTP deaminase family
F822_RS12575	COG0019	diaminopimelate decarboxylase activity
F822_RS12580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F822_RS12585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F822_RS12590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F822_RS12600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F822_RS12605	COG5001	Diguanylate cyclase
F822_RS12605	COG5002	protein histidine kinase activity
F822_RS12635	COG0557	exoribonuclease II activity
F822_RS12640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F822_RS12645	COG0360	Binds together with S18 to 16S ribosomal RNA
F822_RS12650	COG2965	DNA replication, synthesis of RNA primer
F822_RS12655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F822_RS12660	COG0359	binds to the 23S rRNA
F822_RS12670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F822_RS12675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F822_RS12680	COG0720	synthase
F822_RS12700	COG0527	aspartate kinase activity
F822_RS12730	COG3668	Plasmid stabilization system
F822_RS12755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F822_RS12755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F822_RS12765	COG0861	Integral membrane protein TerC family
F822_RS12770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
F822_RS12790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F822_RS12805	COG0473	3-isopropylmalate dehydrogenase activity
F822_RS12820	COG0101	tRNA pseudouridine synthase activity
F822_RS12825	COG0135	phosphoribosylanthranilate isomerase activity
F822_RS12830	COG0133	tryptophan synthase activity
F822_RS12835	COG0159	tryptophan synthase activity
F822_RS12840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F822_RS12845	COG0285	dihydrofolate synthase activity
F822_RS12855	COG1286	toxin biosynthetic process
F822_RS12880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F822_RS12895	COG0215	cysteine-tRNA ligase activity
F822_RS12945	COG0644	oxidoreductase
F822_RS12955	COG3228	Belongs to the MtfA family
F822_RS12960	COG0837	glucose binding
F822_RS12975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F822_RS12980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F822_RS12985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F822_RS12990	COG0779	Required for maturation of 30S ribosomal subunits
F822_RS12995	COG0195	Participates in both transcription termination and antitermination
F822_RS12995	COG2251	uridine kinase activity
F822_RS13000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F822_RS13005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F822_RS13010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F822_RS13045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F822_RS13050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F822_RS13055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F822_RS13060	COG1187	pseudouridine synthase activity
F822_RS13070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F822_RS13075	COG2171	N-acyltransferase activity
F822_RS13085	COG0697	spore germination
F822_RS13090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F822_RS13100	COG0247	lactate metabolic process
F822_RS13120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F822_RS13125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F822_RS13130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F822_RS13135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F822_RS13140	COG0142	geranyltranstransferase activity
F822_RS13155	COG3023	N-Acetylmuramoyl-L-alanine amidase
F822_RS13160	COG0488	(ABC) transporter
F822_RS13175	COG0825	malonyl-CoA metabolic process
F822_RS13180	COG0037	tRNA processing
F822_RS13185	COG1741	Belongs to the pirin family
F822_RS13195	COG2814	Major facilitator Superfamily
F822_RS13215	COG0513	Belongs to the DEAD box helicase family
F822_RS13250	COG1988	membrane-bound metal-dependent
F822_RS13260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F822_RS13275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F822_RS13280	COG1555	photosystem II stabilization
F822_RS13285	COG1217	gtp-binding protein TYPA
F822_RS13330	COG0463	Glycosyl transferase, family 2
F822_RS13340	COG0071	Belongs to the small heat shock protein (HSP20) family
F822_RS13345	COG1472	Belongs to the glycosyl hydrolase 3 family
F822_RS13350	COG0736	holo-[acyl-carrier-protein] synthase activity
F822_RS13355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F822_RS13370	COG1381	Involved in DNA repair and RecF pathway recombination
F822_RS13375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F822_RS13380	COG0571	ribonuclease III activity
F822_RS13390	COG0481	GTPase activity
F822_RS13400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F822_RS13430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F822_RS13435	COG5507	3-demethylubiquinone-9 3-methyltransferase
F822_RS13450	COG1132	(ABC) transporter
F822_RS13455	COG0583	DNA-binding transcription factor activity
F822_RS13505	COG0438	transferase activity, transferring glycosyl groups
F822_RS13515	COG2814	Major facilitator Superfamily
F822_RS13555	COG1733	regulation of RNA biosynthetic process
F822_RS13565	COG2010	Cytochrome c
F822_RS13565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F822_RS13575	COG3045	CreA protein
F822_RS13580	COG3189	MarR family transcriptional regulator
F822_RS13600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F822_RS13640	COG3485	protocatechuate 3,4-dioxygenase
F822_RS13650	COG3384	dioxygenase
F822_RS13730	COG0590	tRNA wobble adenosine to inosine editing
F822_RS13765	COG0363	glucosamine-6-phosphate deaminase activity
F822_RS13790	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
F822_RS13795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F822_RS13800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F822_RS13810	COG0328	RNA-DNA hybrid ribonuclease activity
F822_RS13825	COG1943	Transposase
F822_RS13865	COG2337	Toxic component of a toxin-antitoxin (TA) module
F822_RS13905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F822_RS13930	COG1403	HNH endonuclease
F822_RS13935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F822_RS13955	COG3724	N-succinylarginine dihydrolase activity
F822_RS13960	COG0791	NLP P60 protein
F822_RS13965	COG2183	response to ionizing radiation
F822_RS13980	COG2409	Drug exporters of the RND superfamily
F822_RS13995	COG1902	pentaerythritol trinitrate reductase activity
F822_RS14015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F822_RS14025	COG1538	Outer membrane efflux protein
F822_RS14065	COG0420	3'-5' exonuclease activity
F822_RS14070	COG4717	serine-type aminopeptidase activity
F822_RS14075	COG2853	Lipoprotein
F822_RS14125	COG3040	lipid binding
F822_RS14140	COG5634	Uncharacterized conserved protein (DUF2278)
F822_RS14165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F822_RS14205	COG2111	Na H antiporter
F822_RS14205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F822_RS14210	COG1006	Multisubunit Na H antiporter MnhC subunit
F822_RS14215	COG0651	ATP synthesis coupled electron transport
F822_RS14220	COG1863	multisubunit Na H antiporter MnhE subunit
F822_RS14225	COG2212	antiporter activity
F822_RS14230	COG1320	monovalent cation:proton antiporter activity
F822_RS14240	COG1064	alcohol dehydrogenase
F822_RS14245	COG1252	NADH dehydrogenase
F822_RS14265	COG2135	peptidase activity
F822_RS14300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F822_RS14305	COG3588	fructose-bisphosphate aldolase
F822_RS14315	COG2200	EAL domain
F822_RS14320	COG0123	including yeast histone deacetylase and acetoin utilization protein
F822_RS14365	COG0436	Aminotransferase
F822_RS14380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F822_RS14385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F822_RS14395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F822_RS14410	COG2131	deaminase
F822_RS14430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F822_RS14445	COG4771	TonB-dependent receptor
F822_RS14445	COG1629	transport
F822_RS14470	COG0069	glutamate synthase activity
F822_RS14480	COG0542	response to heat
F822_RS14495	COG1278	Cold shock
F822_RS14500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F822_RS14505	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F822_RS14525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F822_RS14545	COG0356	it plays a direct role in the translocation of protons across the membrane
F822_RS14555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F822_RS14555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F822_RS14560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F822_RS14600	COG1127	ABC transporter
F822_RS14605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F822_RS14625	COG0318	PFAM AMP-dependent synthetase and ligase