locus-tag	class	description
C5B73_RS00035	COG2801	Transposase and inactivated derivatives
C5B73_RS00040	COG2826	transposase and inactivated derivatives, IS30 family
C5B73_RS00060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5B73_RS00065	COG0390	transport system, permease component
C5B73_RS00070	COG0642	Histidine kinase
C5B73_RS00075	COG0745	RESPONSE REGULATOR receiver
C5B73_RS00115	COG0300	oxidoreductase activity
C5B73_RS00120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5B73_RS00165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5B73_RS00170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5B73_RS00175	COG2226	methyltransferase
C5B73_RS00215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5B73_RS00410	COG1192	Involved in chromosome partitioning
C5B73_RS00480	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C5B73_RS00555	COG0714	Associated with various cellular activities
C5B73_RS00625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5B73_RS00660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5B73_RS00685	COG3328	transposase activity
C5B73_RS00705	COG3002	Belongs to the UPF0753 family
C5B73_RS00710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5B73_RS00720	COG0009	L-threonylcarbamoyladenylate synthase
C5B73_RS00740	COG3321	synthase
C5B73_RS00740	COG0604	alcohol dehydrogenase
C5B73_RS00825	COG1131	(ABC) transporter
C5B73_RS00840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5B73_RS00890	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B73_RS00890	COG1902	pentaerythritol trinitrate reductase activity
C5B73_RS00895	COG0300	oxidoreductase activity
C5B73_RS00905	COG0433	COG0433 Predicted ATPase
C5B73_RS00910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5B73_RS00935	COG0531	amino acid
C5B73_RS00945	COG1376	ErfK ybiS ycfS ynhG family protein
C5B73_RS00955	COG5412	phage tail tape measure protein
C5B73_RS00955	COG3953	SLT domain
C5B73_RS00970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5B73_RS00970	COG2755	lipolytic protein G-D-S-L family
C5B73_RS01015	COG0736	holo-[acyl-carrier-protein] synthase activity
C5B73_RS01180	COG5479	isomerase activity
C5B73_RS01180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS01270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B73_RS01270	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C5B73_RS01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B73_RS01325	COG1793	dna ligase
C5B73_RS01325	COG3285	dna ligase
C5B73_RS01335	COG3422	double-strand break repair
C5B73_RS01530	COG2409	Drug exporters of the RND superfamily
C5B73_RS01605	COG2985	domain, Protein
C5B73_RS01615	COG0745	RESPONSE REGULATOR receiver
C5B73_RS01620	COG2936	dipeptidyl-peptidase activity
C5B73_RS01640	COG1309	transcriptional regulator
C5B73_RS01650	COG1073	alpha beta
C5B73_RS01655	COG3835	regulator
C5B73_RS01665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5B73_RS01675	COG0129	dihydroxy-acid dehydratase activity
C5B73_RS01695	COG1959	2 iron, 2 sulfur cluster binding
C5B73_RS01715	COG5001	Diguanylate cyclase
C5B73_RS01715	COG3300	MHYT domain
C5B73_RS01745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS01750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS01810	COG1846	Transcriptional regulator
C5B73_RS01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS01865	COG0704	Plays a role in the regulation of phosphate uptake
C5B73_RS01915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5B73_RS01925	COG0583	DNA-binding transcription factor activity
C5B73_RS02030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5B73_RS02035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5B73_RS02040	COG1234	tRNA 3'-trailer cleavage
C5B73_RS02065	COG3191	aminopeptidase activity
C5B73_RS02075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5B73_RS02080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5B73_RS02085	COG1335	isochorismatase
C5B73_RS02095	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5B73_RS02120	COG2252	PERMEase
C5B73_RS02125	COG0058	SHG alpha-glucan phosphorylase activity
C5B73_RS02130	COG0366	Alpha amylase catalytic
C5B73_RS02135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C5B73_RS02150	COG2409	Drug exporters of the RND superfamily
C5B73_RS02155	COG0183	Belongs to the thiolase family
C5B73_RS02160	COG0346	lactoylglutathione lyase activity
C5B73_RS02190	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C5B73_RS02215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5B73_RS02230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5B73_RS02235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5B73_RS02240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5B73_RS02245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5B73_RS02250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5B73_RS02255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5B73_RS02260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5B73_RS02265	COG0356	it plays a direct role in the translocation of protons across the membrane
C5B73_RS02275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5B73_RS02285	COG2890	protein-(glutamine-N5) methyltransferase activity
C5B73_RS02290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5B73_RS02295	COG0254	rRNA binding
C5B73_RS02305	COG0083	homoserine kinase activity
C5B73_RS02310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5B73_RS02315	COG0460	homoserine dehydrogenase
C5B73_RS02320	COG0019	diaminopimelate decarboxylase activity
C5B73_RS02325	COG0018	arginyl-trna synthetase
C5B73_RS02370	COG0443	Heat shock 70 kDa protein
C5B73_RS02385	COG1024	Enoyl-CoA hydratase
C5B73_RS02390	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS02420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5B73_RS02445	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5B73_RS02450	COG0022	dehydrogenase e1 component
C5B73_RS02470	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS02490	COG2223	nitrite transmembrane transporter activity
C5B73_RS02515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C5B73_RS02545	COG0277	FAD linked oxidase domain protein
C5B73_RS02585	COG2205	protein histidine kinase activity
C5B73_RS02590	COG0745	RESPONSE REGULATOR receiver
C5B73_RS02610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS02620	COG0424	maF-like protein
C5B73_RS02635	COG4770	biotin carboxylase activity
C5B73_RS02660	COG1522	sequence-specific DNA binding
C5B73_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS02675	COG1201	RNA secondary structure unwinding
C5B73_RS02680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5B73_RS02690	COG1309	transcriptional regulator
C5B73_RS02705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5B73_RS02710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B73_RS02740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5B73_RS02740	COG1473	amidohydrolase
C5B73_RS02760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B73_RS02765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5B73_RS02775	COG3883	PFAM NLP P60 protein
C5B73_RS02775	COG0791	NLP P60 protein
C5B73_RS02815	COG2009	succinate dehydrogenase
C5B73_RS02825	COG1053	succinate dehydrogenase
C5B73_RS02845	COG2003	Belongs to the UPF0758 family
C5B73_RS02850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5B73_RS02855	COG1121	(ABC) transporter
C5B73_RS02865	COG1686	Belongs to the peptidase S11 family
C5B73_RS02870	COG1295	ribonuclease BN
C5B73_RS02875	COG0180	Tryptophanyl-tRNA synthetase
C5B73_RS02900	COG2267	carboxylic ester hydrolase activity
C5B73_RS02930	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS02935	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS02950	COG0183	Belongs to the thiolase family
C5B73_RS02960	COG2207	Transcriptional regulator
C5B73_RS02975	COG2873	o-acetylhomoserine
C5B73_RS02980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5B73_RS03000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5B73_RS03005	COG1872	DUF167
C5B73_RS03015	COG0587	DNA-directed DNA polymerase activity
C5B73_RS03030	COG2267	carboxylic ester hydrolase activity
C5B73_RS03075	COG0519	Catalyzes the synthesis of GMP from XMP
C5B73_RS03075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5B73_RS03080	COG2267	carboxylic ester hydrolase activity
C5B73_RS03085	COG0516	GMP reductase activity
C5B73_RS03120	COG1595	DNA-templated transcription, initiation
C5B73_RS03130	COG0459	protein refolding
C5B73_RS03135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5B73_RS03145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5B73_RS03150	COG0456	acetyltransferase
C5B73_RS03155	COG1214	PFAM Peptidase M22, glycoprotease
C5B73_RS03155	COG0456	acetyltransferase
C5B73_RS03170	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5B73_RS03190	COG2814	Major facilitator Superfamily
C5B73_RS03195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5B73_RS03225	COG1983	PspC domain protein
C5B73_RS03230	COG0488	(ABC) transporter
C5B73_RS03285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B73_RS03290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5B73_RS03295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5B73_RS03305	COG0842	Transport permease protein
C5B73_RS03305	COG1131	(ABC) transporter
C5B73_RS03305	COG1716	ATPase activity
C5B73_RS03380	COG1674	ftsk spoiiie
C5B73_RS03390	COG1404	Belongs to the peptidase S8 family
C5B73_RS03395	COG3266	domain, Protein
C5B73_RS03410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5B73_RS03415	COG1937	Protein conserved in bacteria
C5B73_RS03430	COG0745	RESPONSE REGULATOR receiver
C5B73_RS03435	COG0477	Major facilitator Superfamily
C5B73_RS03450	COG0101	tRNA pseudouridine synthase activity
C5B73_RS03455	COG0203	ribosomal protein L17
C5B73_RS03460	COG0202	RNA polymerase activity
C5B73_RS03465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5B73_RS03470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5B73_RS03475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5B73_RS03480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5B73_RS03485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5B73_RS03500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B73_RS03505	COG0454	-acetyltransferase
C5B73_RS03510	COG1674	ftsk spoiiie
C5B73_RS03515	COG1404	Belongs to the peptidase S8 family
C5B73_RS03525	COG0464	growth
C5B73_RS03530	COG3266	domain, Protein
C5B73_RS03555	COG5651	PPE family
C5B73_RS03630	COG1490	D-aminoacyl-tRNA deacylase activity
C5B73_RS03640	COG0563	adenylate kinase activity
C5B73_RS03645	COG0201	protein transport
C5B73_RS03650	COG0200	Binds to the 23S rRNA
C5B73_RS03655	COG1841	ribosomal large subunit assembly
C5B73_RS03660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5B73_RS03665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5B73_RS03670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5B73_RS03675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5B73_RS03685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5B73_RS03690	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5B73_RS03695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5B73_RS03700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5B73_RS03705	COG3590	peptidase
C5B73_RS03760	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C5B73_RS03760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS03775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS03795	COG0564	pseudouridine synthase activity
C5B73_RS03815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5B73_RS03820	COG0255	Belongs to the universal ribosomal protein uL29 family
C5B73_RS03825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5B73_RS03830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5B73_RS03835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5B73_RS03840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5B73_RS03845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5B73_RS03850	COG0089	rRNA binding
C5B73_RS03855	COG0088	Forms part of the polypeptide exit tunnel
C5B73_RS03860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5B73_RS03865	COG0051	transcription antitermination factor activity, RNA binding
C5B73_RS03905	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS03910	COG1309	transcriptional regulator
C5B73_RS03915	COG1024	Enoyl-CoA hydratase
C5B73_RS03940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS03965	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS03985	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS03990	COG2072	flavoprotein involved in K transport
C5B73_RS04005	COG4974	Belongs to the 'phage' integrase family
C5B73_RS04105	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C5B73_RS04160	COG0714	Associated with various cellular activities
C5B73_RS04245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5B73_RS04330	COG0501	Belongs to the peptidase M48B family
C5B73_RS04365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5B73_RS04385	COG2132	Multicopper oxidase
C5B73_RS04400	COG2217	Heavy metal translocating P-type atpase
C5B73_RS04410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5B73_RS04420	COG2826	transposase and inactivated derivatives, IS30 family
C5B73_RS04425	COG2801	Transposase and inactivated derivatives
C5B73_RS04430	COG2963	transposase activity
C5B73_RS04435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5B73_RS04440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5B73_RS04445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5B73_RS04450	COG0798	PFAM Bile acid sodium symporter
C5B73_RS04465	COG0492	ferredoxin-NADP+ reductase activity
C5B73_RS04500	COG0785	Cytochrome C biogenesis protein
C5B73_RS04535	COG3328	transposase activity
C5B73_RS04540	COG2226	methyltransferase
C5B73_RS04550	COG2409	Drug exporters of the RND superfamily
C5B73_RS04555	COG1937	Protein conserved in bacteria
C5B73_RS04595	COG0477	Major facilitator Superfamily
C5B73_RS04600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5B73_RS04655	COG0596	Alpha beta hydrolase
C5B73_RS04705	COG2814	Major facilitator Superfamily
C5B73_RS04715	COG0477	Major facilitator Superfamily
C5B73_RS04760	COG3123	guanosine phosphorylase activity
C5B73_RS04765	COG2409	Drug exporters of the RND superfamily
C5B73_RS04770	COG1937	Protein conserved in bacteria
C5B73_RS04790	COG0183	Belongs to the thiolase family
C5B73_RS04810	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C5B73_RS04815	COG0564	pseudouridine synthase activity
C5B73_RS04820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5B73_RS04920	COG3285	dna ligase
C5B73_RS04920	COG1793	dna ligase
C5B73_RS04935	COG1024	Enoyl-CoA hydratase
C5B73_RS04945	COG0656	L-ascorbic acid biosynthetic process
C5B73_RS04975	COG2018	Roadblock/LC7 domain
C5B73_RS05010	COG1846	Transcriptional regulator
C5B73_RS05055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5B73_RS05070	COG0259	pyridoxamine-phosphate oxidase activity
C5B73_RS05085	COG0545	Peptidyl-prolyl cis-trans isomerase
C5B73_RS05130	COG2814	Major facilitator Superfamily
C5B73_RS05140	COG1278	Cold shock
C5B73_RS05150	COG1652	LysM domain
C5B73_RS05170	COG0308	aminopeptidase N
C5B73_RS05175	COG1280	lysine exporter protein (LysE YggA)
C5B73_RS05185	COG1061	Type III restriction enzyme res subunit
C5B73_RS05205	COG1595	DNA-templated transcription, initiation
C5B73_RS05220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5B73_RS05225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B73_RS05235	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5B73_RS05240	COG1169	isochorismate synthase
C5B73_RS05250	COG0204	Acyl-transferase
C5B73_RS05255	COG1216	Glycosyl transferase, family 2
C5B73_RS05305	COG1316	TRANSCRIPTIONal
C5B73_RS05315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5B73_RS05320	COG0581	inorganic phosphate transmembrane transporter activity
C5B73_RS05335	COG0454	-acetyltransferase
C5B73_RS05335	COG0456	acetyltransferase
C5B73_RS05340	COG0745	RESPONSE REGULATOR receiver
C5B73_RS05360	COG2897	thiosulfate sulfurtransferase activity
C5B73_RS05370	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C5B73_RS05375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5B73_RS05380	COG4988	ABC transporter
C5B73_RS05385	COG1294	oxidase, subunit
C5B73_RS05390	COG1271	oxidase subunit
C5B73_RS05420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5B73_RS05455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5B73_RS05465	COG1362	aminopeptidase activity
C5B73_RS05470	COG0047	phosphoribosylformylglycinamidine synthase activity
C5B73_RS05475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5B73_RS05510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5B73_RS05520	COG0436	Aminotransferase
C5B73_RS05545	COG0537	adenosine 5'-monophosphoramidase activity
C5B73_RS05575	COG0745	RESPONSE REGULATOR receiver
C5B73_RS05580	COG2205	protein histidine kinase activity
C5B73_RS05600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5B73_RS05625	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS05630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS05645	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05650	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05660	COG1024	Enoyl-CoA hydratase
C5B73_RS05680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS05710	COG2124	cytochrome p450
C5B73_RS05715	COG0183	Belongs to the thiolase family
C5B73_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS05750	COG1024	Enoyl-CoA hydratase
C5B73_RS05775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS05780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS05785	COG0183	Belongs to the thiolase family
C5B73_RS05790	COG1309	transcriptional regulator
C5B73_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS05805	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05810	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS05815	COG1024	Enoyl-CoA hydratase
C5B73_RS05820	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05825	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05830	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05840	COG2814	Major facilitator Superfamily
C5B73_RS05870	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS05875	COG2267	carboxylic ester hydrolase activity
C5B73_RS05880	COG0346	lactoylglutathione lyase activity
C5B73_RS05885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B73_RS05900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B73_RS05905	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C5B73_RS05910	COG3971	2-oxopent-4-enoate hydratase activity
C5B73_RS05920	COG1053	succinate dehydrogenase
C5B73_RS05925	COG2030	dehydratase
C5B73_RS05935	COG1396	sequence-specific DNA binding
C5B73_RS05940	COG5522	Integral membrane protein (intg_mem_TP0381)
C5B73_RS05960	COG2264	protein methyltransferase activity
C5B73_RS06000	COG4977	sequence-specific DNA binding
C5B73_RS06000	COG1917	Cupin 2, conserved barrel domain protein
C5B73_RS06030	COG0714	Associated with various cellular activities
C5B73_RS06045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5B73_RS06070	COG2030	dehydratase
C5B73_RS06075	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS06080	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS06085	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS06090	COG1309	transcriptional regulator
C5B73_RS06095	COG3387	PFAM Glycoside hydrolase 15-related
C5B73_RS06110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5B73_RS06130	COG1733	regulation of RNA biosynthetic process
C5B73_RS06135	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS06140	COG1024	Enoyl-CoA hydratase
C5B73_RS06150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5B73_RS06155	COG0215	cysteine-tRNA ligase activity
C5B73_RS06160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5B73_RS06165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5B73_RS06180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5B73_RS06190	COG0288	reversible hydration of carbon dioxide
C5B73_RS06195	COG1194	a g-specific adenine glycosylase
C5B73_RS06235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5B73_RS06255	COG4585	Histidine kinase
C5B73_RS06260	COG2197	response regulator
C5B73_RS06295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5B73_RS06310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5B73_RS06315	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5B73_RS06320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5B73_RS06340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5B73_RS06355	COG0302	gtp cyclohydrolase
C5B73_RS06360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5B73_RS06385	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS06390	COG4221	oxidoreductase activity
C5B73_RS06395	COG0583	DNA-binding transcription factor activity
C5B73_RS06415	COG0037	tRNA processing
C5B73_RS06425	COG2027	D-alanyl-D-alanine carboxypeptidase
C5B73_RS06440	COG0442	prolyl-tRNA aminoacylation
C5B73_RS06565	COG1733	regulation of RNA biosynthetic process
C5B73_RS06575	COG0470	DNA polymerase III
C5B73_RS06585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5B73_RS06585	COG1754	DNA topoisomerase type I activity
C5B73_RS06590	COG1278	Cold shock
C5B73_RS06595	COG1111	helicase
C5B73_RS06595	COG1205	dead DEAH box helicase
C5B73_RS06650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5B73_RS06655	COG0601	transmembrane transport
C5B73_RS06660	COG4166	transmembrane transport
C5B73_RS06665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B73_RS06670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5B73_RS06680	COG0596	Alpha beta hydrolase
C5B73_RS06690	COG0494	nUDIX hydrolase
C5B73_RS06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5B73_RS06715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B73_RS06735	COG0003	Pfam Anion-transporting ATPase
C5B73_RS06745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C5B73_RS06755	COG1408	metallophosphoesterase
C5B73_RS06775	COG1910	domain protein
C5B73_RS06830	COG2186	Transcriptional regulator
C5B73_RS06835	COG0546	phosphoglycolate phosphatase activity
C5B73_RS06855	COG1802	Transcriptional regulator
C5B73_RS06915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS06955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B73_RS06985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5B73_RS07010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5B73_RS07015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5B73_RS07045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C5B73_RS07065	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5B73_RS07065	COG1024	Enoyl-CoA hydratase
C5B73_RS07070	COG0183	Belongs to the thiolase family
C5B73_RS07085	COG2409	Drug exporters of the RND superfamily
C5B73_RS07095	COG2321	neutral zinc metallopeptidase
C5B73_RS07105	COG2321	neutral zinc metallopeptidase
C5B73_RS07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B73_RS07165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5B73_RS07225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5B73_RS07245	COG0343	queuine tRNA-ribosyltransferase activity
C5B73_RS07270	COG2409	Drug exporters of the RND superfamily
C5B73_RS07285	COG0300	oxidoreductase activity
C5B73_RS07290	COG0583	DNA-binding transcription factor activity
C5B73_RS07310	COG2124	cytochrome p450
C5B73_RS07320	COG2161	toxin-antitoxin pair type II binding
C5B73_RS07325	COG4115	mRNA cleavage
C5B73_RS07345	COG0287	Prephenate dehydrogenase
C5B73_RS07355	COG1132	(ABC) transporter
C5B73_RS07370	COG0270	DNA (cytosine-5-)-methyltransferase activity
C5B73_RS07380	COG2188	Transcriptional regulator
C5B73_RS07385	COG2902	Dehydrogenase
C5B73_RS07390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C5B73_RS07395	COG0604	alcohol dehydrogenase
C5B73_RS07400	COG1733	regulation of RNA biosynthetic process
C5B73_RS07435	COG2986	histidine ammonia-lyase
C5B73_RS07445	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS07460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5B73_RS07465	COG1228	amidohydrolase
C5B73_RS07470	COG0010	Belongs to the arginase family
C5B73_RS07475	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C5B73_RS07505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5B73_RS07510	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS07535	COG3321	synthase
C5B73_RS07535	COG0604	alcohol dehydrogenase
C5B73_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS07560	COG1216	Glycosyl transferase, family 2
C5B73_RS07565	COG1162	GTPase activity
C5B73_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS07585	COG1216	Glycosyl transferase, family 2
C5B73_RS07605	COG1088	dTDP-glucose 4,6-dehydratase activity
C5B73_RS07655	COG0277	FAD linked oxidase domain protein
C5B73_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS07680	COG1403	HNH endonuclease
C5B73_RS07745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS07750	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5B73_RS07750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B73_RS07750	COG3321	synthase
C5B73_RS07755	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS07765	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C5B73_RS07775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS07775	COG5479	isomerase activity
C5B73_RS07785	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS07790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS07795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5B73_RS07800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5B73_RS07805	COG0671	phosphoesterase, PA-phosphatase related
C5B73_RS07810	COG1216	Glycosyl transferase, family 2
C5B73_RS07830	COG2385	sporulation resulting in formation of a cellular spore
C5B73_RS07840	COG0561	phosphatase activity
C5B73_RS07915	COG0204	Acyl-transferase
C5B73_RS07940	COG5001	Diguanylate cyclase
C5B73_RS07940	COG3300	MHYT domain
C5B73_RS07945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5B73_RS07980	COG0406	alpha-ribazole phosphatase activity
C5B73_RS08005	COG1316	TRANSCRIPTIONal
C5B73_RS08015	COG1528	Iron-storage protein
C5B73_RS08055	COG2119	membrane
C5B73_RS08085	COG0326	Molecular chaperone. Has ATPase activity
C5B73_RS08115	COG1276	copper resistance
C5B73_RS08130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5B73_RS08135	COG2501	S4 domain
C5B73_RS08140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5B73_RS08140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5B73_RS08155	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
C5B73_RS08220	COG0070	glutamate synthase
C5B73_RS08220	COG0069	glutamate synthase activity
C5B73_RS08220	COG0067	glutamate synthase
C5B73_RS08235	COG0477	Major facilitator Superfamily
C5B73_RS08255	COG0714	Associated with various cellular activities
C5B73_RS08300	COG1716	ATPase activity
C5B73_RS08305	COG1716	ATPase activity
C5B73_RS08320	COG0768	penicillin binding
C5B73_RS08325	COG0515	serine threonine protein kinase
C5B73_RS08330	COG0515	serine threonine protein kinase
C5B73_RS08330	COG2815	serine threonine protein kinase
C5B73_RS08345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5B73_RS08400	COG1733	regulation of RNA biosynthetic process
C5B73_RS08430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5B73_RS08435	COG0187	DNA topoisomerase II activity
C5B73_RS08445	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C5B73_RS08450	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5B73_RS08455	COG0592	DNA-directed DNA polymerase activity
C5B73_RS08460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5B73_RS08465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5B73_RS08470	COG0594	ribonuclease P activity
C5B73_RS08475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5B73_RS08480	COG0706	membrane insertase activity
C5B73_RS08490	COG0357	Ribosomal RNA small subunit methyltransferase G
C5B73_RS08495	COG1192	Involved in chromosome partitioning
C5B73_RS08510	COG3409	Peptidoglycan-binding domain 1 protein
C5B73_RS08510	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5B73_RS08530	COG1595	DNA-templated transcription, initiation
C5B73_RS08550	COG0617	tRNA 3'-terminal CCA addition
C5B73_RS08560	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5B73_RS08565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5B73_RS08570	COG1984	allophanate hydrolase subunit 2
C5B73_RS08625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS08630	COG3590	peptidase
C5B73_RS08635	COG1376	ErfK ybiS ycfS ynhG family protein
C5B73_RS08645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B73_RS08665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS08670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS08690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5B73_RS08715	COG0328	RNA-DNA hybrid ribonuclease activity
C5B73_RS08725	COG0579	oxidoreductase
C5B73_RS08770	COG3903	Transcriptional regulator
C5B73_RS08770	COG3629	intracellular signal transduction
C5B73_RS08775	COG0596	Alpha beta hydrolase
C5B73_RS08790	COG0604	alcohol dehydrogenase
C5B73_RS08795	COG1132	(ABC) transporter
C5B73_RS08800	COG0247	lactate metabolic process
C5B73_RS08800	COG0277	FAD linked oxidase domain protein
C5B73_RS08835	COG1053	succinate dehydrogenase
C5B73_RS08860	COG1716	ATPase activity
C5B73_RS08885	COG0791	NLP P60 protein
C5B73_RS08895	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS08945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5B73_RS08955	COG2070	2-Nitropropane dioxygenase
C5B73_RS08970	COG0360	Binds together with S18 to 16S ribosomal RNA
C5B73_RS08980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5B73_RS08985	COG0359	binds to the 23S rRNA
C5B73_RS08995	COG1309	transcriptional regulator
C5B73_RS09065	COG1358	cellular component organization or biogenesis
C5B73_RS09075	COG2318	DinB family
C5B73_RS09090	COG1902	pentaerythritol trinitrate reductase activity
C5B73_RS09125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5B73_RS09145	COG1695	Transcriptional regulator
C5B73_RS09165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5B73_RS09180	COG1653	transport
C5B73_RS09195	COG4948	Mandelate Racemase Muconate Lactonizing
C5B73_RS09205	COG3842	ATPase activity
C5B73_RS09220	COG0765	amino acid transport
C5B73_RS09225	COG1126	abc transporter atp-binding protein
C5B73_RS09285	COG0495	leucyl-tRNA aminoacylation
C5B73_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS09305	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
C5B73_RS09320	COG3220	belongs to the UPF0276 family
C5B73_RS09345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5B73_RS09350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5B73_RS09380	COG1678	Uncharacterized ACR, COG1678
C5B73_RS09395	COG1929	Belongs to the glycerate kinase type-1 family
C5B73_RS09400	COG1733	regulation of RNA biosynthetic process
C5B73_RS09415	COG1476	TRANSCRIPTIONal
C5B73_RS09425	COG1131	(ABC) transporter
C5B73_RS09430	COG0640	Transcriptional regulator
C5B73_RS09440	COG2860	membrane
C5B73_RS09450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5B73_RS09495	COG2197	response regulator
C5B73_RS09510	COG2409	Drug exporters of the RND superfamily
C5B73_RS09520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5B73_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS09545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C5B73_RS09565	COG0500	methyltransferase
C5B73_RS09570	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS09605	COG4981	capsule polysaccharide biosynthetic process
C5B73_RS09625	COG1472	Belongs to the glycosyl hydrolase 3 family
C5B73_RS09630	COG1309	transcriptional regulator
C5B73_RS09640	COG2030	dehydratase
C5B73_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS09660	COG1073	alpha beta
C5B73_RS09695	COG1131	(ABC) transporter
C5B73_RS09705	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C5B73_RS09730	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS09755	COG1024	Enoyl-CoA hydratase
C5B73_RS09760	COG1024	Enoyl-CoA hydratase
C5B73_RS09765	COG0596	Alpha beta hydrolase
C5B73_RS09765	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5B73_RS09800	COG1956	GAF domain-containing protein
C5B73_RS09935	COG2188	Transcriptional regulator
C5B73_RS09960	COG0717	Belongs to the dCTP deaminase family
C5B73_RS09990	COG0443	Heat shock 70 kDa protein
C5B73_RS10000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5B73_RS10015	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS10020	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS10030	COG0247	lactate metabolic process
C5B73_RS10030	COG2181	nitrate reductase activity
C5B73_RS10060	COG2197	response regulator
C5B73_RS10065	COG0443	Heat shock 70 kDa protein
C5B73_RS10090	COG1846	Transcriptional regulator
C5B73_RS10095	COG0477	Major facilitator Superfamily
C5B73_RS10100	COG0443	Heat shock 70 kDa protein
C5B73_RS10105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5B73_RS10110	COG0484	heat shock protein binding
C5B73_RS10115	COG0789	Transcriptional regulator
C5B73_RS10135	COG0542	response to heat
C5B73_RS10180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS10185	COG2197	response regulator
C5B73_RS10190	COG4585	Histidine kinase
C5B73_RS10210	COG0586	Pfam SNARE associated Golgi protein
C5B73_RS10240	COG2030	dehydratase
C5B73_RS10260	COG4129	membrane
C5B73_RS10265	COG1994	Peptidase M50
C5B73_RS10275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5B73_RS10280	COG2197	response regulator
C5B73_RS10285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5B73_RS10300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5B73_RS10350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5B73_RS10360	COG0693	protein deglycase activity
C5B73_RS10370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B73_RS10385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS10400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5B73_RS10405	COG0515	serine threonine protein kinase
C5B73_RS10410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5B73_RS10425	COG0352	thiamine-phosphate diphosphorylase activity
C5B73_RS10430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B73_RS10440	COG2022	thiamine diphosphate biosynthetic process
C5B73_RS10445	COG1131	(ABC) transporter
C5B73_RS10470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS10520	COG0351	phosphomethylpyrimidine kinase
C5B73_RS10540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B73_RS10550	COG0596	Alpha beta hydrolase
C5B73_RS10555	COG0523	cobalamin synthesis protein
C5B73_RS10560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B73_RS10565	COG1116	anion transmembrane transporter activity
C5B73_RS10570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B73_RS10590	COG0475	glutathione-regulated potassium exporter activity
C5B73_RS10600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B73_RS10630	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS10675	COG0714	Associated with various cellular activities
C5B73_RS10680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS10685	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS10695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5B73_RS10745	COG2032	superoxide dismutase activity
C5B73_RS10750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5B73_RS10775	COG0651	ATP synthesis coupled electron transport
C5B73_RS10780	COG1006	Multisubunit Na H antiporter MnhC subunit
C5B73_RS10785	COG2111	Na H antiporter
C5B73_RS10785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5B73_RS10790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5B73_RS10830	COG0688	phosphatidylethanolamine metabolic process
C5B73_RS10850	COG0459	protein refolding
C5B73_RS10880	COG1309	transcriptional regulator
C5B73_RS10900	COG1505	serine-type exopeptidase activity
C5B73_RS10925	COG2130	NADP-dependent
C5B73_RS10975	COG1802	Transcriptional regulator
C5B73_RS11000	COG0683	leucine binding
C5B73_RS11005	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS11060	COG1793	dna ligase
C5B73_RS11095	COG2224	Isocitrate lyase
C5B73_RS11115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS11120	COG0513	Belongs to the DEAD box helicase family
C5B73_RS11135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B73_RS11185	COG2326	polyphosphate kinase activity
C5B73_RS11205	COG1725	Transcriptional regulator
C5B73_RS11215	COG2226	methyltransferase
C5B73_RS11220	COG3268	Saccharopine dehydrogenase
C5B73_RS11225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5B73_RS11235	COG2733	membrane
C5B73_RS11255	COG3795	YCII-related domain
C5B73_RS11260	COG4941	Belongs to the sigma-70 factor family
C5B73_RS11270	COG0596	Alpha beta hydrolase
C5B73_RS11285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5B73_RS11315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5B73_RS11330	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS11365	COG0588	phosphoglycerate mutase activity
C5B73_RS11370	COG2936	dipeptidyl-peptidase activity
C5B73_RS11380	COG1733	regulation of RNA biosynthetic process
C5B73_RS11385	COG5002	protein histidine kinase activity
C5B73_RS11390	COG0745	RESPONSE REGULATOR receiver
C5B73_RS11425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5B73_RS11460	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5B73_RS11465	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5B73_RS11470	COG0181	hydroxymethylbilane synthase activity
C5B73_RS11510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5B73_RS11515	COG0406	alpha-ribazole phosphatase activity
C5B73_RS11530	COG0785	Cytochrome C biogenesis protein
C5B73_RS11540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5B73_RS11575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5B73_RS11600	COG1950	PFAM Membrane protein of
C5B73_RS11645	COG0431	NADPH-dependent FMN reductase
C5B73_RS11680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C5B73_RS11700	COG2226	methyltransferase
C5B73_RS11705	COG0243	molybdopterin cofactor binding
C5B73_RS11710	COG0667	Aldo Keto reductase
C5B73_RS11715	COG1309	transcriptional regulator
C5B73_RS11755	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS11785	COG0142	geranyltranstransferase activity
C5B73_RS11790	COG0501	Belongs to the peptidase M48B family
C5B73_RS11805	COG1666	GTP binding
C5B73_RS11825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5B73_RS11850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5B73_RS11855	COG0081	regulation of translation
C5B73_RS11865	COG0477	Major facilitator Superfamily
C5B73_RS11870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5B73_RS11875	COG0222	ribosome binding
C5B73_RS11885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS11890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS11935	COG0085	RNA polymerase activity
C5B73_RS11940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5B73_RS11945	COG3177	Filamentation induced by cAMP protein fic
C5B73_RS11955	COG0640	Transcriptional regulator
C5B73_RS11975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B73_RS11980	COG0667	Aldo Keto reductase
C5B73_RS12015	COG5280	Phage tail tape measure protein TP901
C5B73_RS12015	COG3953	SLT domain
C5B73_RS12040	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C5B73_RS12055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5B73_RS12060	COG0049	tRNA binding
C5B73_RS12065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5B73_RS12070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5B73_RS12085	COG1309	transcriptional regulator
C5B73_RS12110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5B73_RS12175	COG0243	molybdopterin cofactor binding
C5B73_RS12200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS12205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS12250	COG1309	transcriptional regulator
C5B73_RS12255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B73_RS12270	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS12280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS12290	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS12430	COG0596	Alpha beta hydrolase
C5B73_RS12475	COG2837	iron assimilation
C5B73_RS12490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5B73_RS12505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5B73_RS12515	COG1595	DNA-templated transcription, initiation
C5B73_RS12520	COG2272	Belongs to the type-B carboxylesterase lipase family
C5B73_RS12525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5B73_RS12535	COG0667	Aldo Keto reductase
C5B73_RS12540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B73_RS12560	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS12585	COG0166	Belongs to the GPI family
C5B73_RS12610	COG0739	heme binding
C5B73_RS12615	COG0045	succinate-CoA ligase (ADP-forming) activity
C5B73_RS12650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5B73_RS12655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5B73_RS12660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5B73_RS12665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5B73_RS12675	COG0254	rRNA binding
C5B73_RS12710	COG2018	Roadblock/LC7 domain
C5B73_RS12715	COG5002	protein histidine kinase activity
C5B73_RS12720	COG0745	RESPONSE REGULATOR receiver
C5B73_RS12725	COG2205	protein histidine kinase activity
C5B73_RS12730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B73_RS12735	COG0315	cyclic pyranopterin monophosphate synthase activity
C5B73_RS12735	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5B73_RS12765	COG1970	mechanosensitive ion channel activity
C5B73_RS12780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5B73_RS12785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5B73_RS12795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5B73_RS12890	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS12895	COG4221	oxidoreductase activity
C5B73_RS12910	COG1725	Transcriptional regulator
C5B73_RS12930	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5B73_RS12940	COG0084	hydrolase, TatD family'
C5B73_RS12945	COG3583	domain protein
C5B73_RS12955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5B73_RS12970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5B73_RS12975	COG0488	(ABC) transporter
C5B73_RS13000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5B73_RS13005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5B73_RS13010	COG0193	aminoacyl-tRNA hydrolase activity
C5B73_RS13015	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS13020	COG1234	tRNA 3'-trailer cleavage
C5B73_RS13025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5B73_RS13030	COG3572	ergothioneine biosynthetic process
C5B73_RS13035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5B73_RS13040	COG0121	glutamine amidotransferase
C5B73_RS13045	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C5B73_RS13060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C5B73_RS13085	COG3956	TIGRFAM MazG family protein
C5B73_RS13090	COG2409	Drug exporters of the RND superfamily
C5B73_RS13115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5B73_RS13120	COG0019	diaminopimelate decarboxylase activity
C5B73_RS13135	COG4166	transmembrane transport
C5B73_RS13140	COG0601	transmembrane transport
C5B73_RS13175	COG0148	phosphopyruvate hydratase activity
C5B73_RS13200	COG3104	oligopeptide transport
C5B73_RS13205	COG0531	amino acid
C5B73_RS13225	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS13275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B73_RS13290	COG2813	Specifically methylates the guanine in position
C5B73_RS13300	COG0183	Belongs to the thiolase family
C5B73_RS13305	COG2755	lipolytic protein G-D-S-L family
C5B73_RS13320	COG0668	transmembrane transport
C5B73_RS13355	COG4941	Belongs to the sigma-70 factor family
C5B73_RS13400	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS13410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5B73_RS13420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5B73_RS13430	COG0494	nUDIX hydrolase
C5B73_RS13480	COG1331	Highly conserved protein containing a thioredoxin domain
C5B73_RS13485	COG1560	Kdo2-lipid A biosynthetic process
C5B73_RS13500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5B73_RS13505	COG1072	(Pantothenic acid kinase))
C5B73_RS13515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5B73_RS13535	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
C5B73_RS13555	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS13580	COG3795	YCII-related domain
C5B73_RS13585	COG4941	Belongs to the sigma-70 factor family
C5B73_RS13595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5B73_RS13610	COG5479	isomerase activity
C5B73_RS13610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS13630	COG1722	exodeoxyribonuclease VII activity
C5B73_RS13635	COG1570	exodeoxyribonuclease VII activity
C5B73_RS13655	COG0420	3'-5' exonuclease activity
C5B73_RS13660	COG0419	ATPase involved in DNA repair
C5B73_RS13665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5B73_RS13665	COG2169	Transcriptional regulator
C5B73_RS13680	COG1966	Carbon starvation protein
C5B73_RS13690	COG1175	transmembrane transport
C5B73_RS13695	COG0395	ABC-type sugar transport system, permease component
C5B73_RS13700	COG0778	Nitroreductase
C5B73_RS13715	COG0604	alcohol dehydrogenase
C5B73_RS13720	COG0012	GTP binding
C5B73_RS13760	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C5B73_RS13855	COG1174	glycine betaine transport
C5B73_RS13875	COG2814	Major facilitator Superfamily
C5B73_RS13890	COG3757	hydrolase, family 25
C5B73_RS13905	COG1051	belongs to the nudix hydrolase family
C5B73_RS13910	COG2154	pterin-4-alpha-carbinolamine dehydratase
C5B73_RS13915	COG1217	gtp-binding protein TYPA
C5B73_RS13920	COG0747	negative chemotaxis
C5B73_RS13925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5B73_RS13945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C5B73_RS13950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5B73_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS13965	COG0506	proline dehydrogenase activity
C5B73_RS13985	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5B73_RS14000	COG1611	Belongs to the LOG family
C5B73_RS14005	COG1611	Belongs to the LOG family
C5B73_RS14010	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS14020	COG0463	Glycosyl transferase, family 2
C5B73_RS14035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5B73_RS14040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B73_RS14045	COG5662	AntiSigma factor
C5B73_RS14065	COG1309	transcriptional regulator
C5B73_RS14070	COG1131	(ABC) transporter
C5B73_RS14075	COG3559	Exporter of polyketide antibiotics
C5B73_RS14080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C5B73_RS14085	COG0297	glycogen (starch) synthase activity
C5B73_RS14100	COG0519	Catalyzes the synthesis of GMP from XMP
C5B73_RS14130	COG2239	Acts as a magnesium transporter
C5B73_RS14135	COG2301	Belongs to the HpcH HpaI aldolase family
C5B73_RS14170	COG0445	tRNA wobble uridine modification
C5B73_RS14180	COG0613	PHP domain protein
C5B73_RS14185	COG0598	Magnesium transport protein CorA
C5B73_RS14195	COG1174	glycine betaine transport
C5B73_RS14245	COG1309	transcriptional regulator
C5B73_RS14260	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5B73_RS14260	COG0567	Dehydrogenase, E1 component
C5B73_RS14275	COG1131	(ABC) transporter
C5B73_RS14285	COG0435	Glutathione S-transferase
C5B73_RS14290	COG1024	Enoyl-CoA hydratase
C5B73_RS14295	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS14300	COG2365	Tyrosine phosphatase family
C5B73_RS14360	COG0596	Alpha beta hydrolase
C5B73_RS14370	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS14375	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS14400	COG2375	cellular response to nickel ion
C5B73_RS14400	COG1132	(ABC) transporter
C5B73_RS14405	COG1132	(ABC) transporter
C5B73_RS14425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B73_RS14430	COG2124	cytochrome p450
C5B73_RS14435	COG3383	formate dehydrogenase (NAD+) activity
C5B73_RS14440	COG0748	coenzyme F420 binding
C5B73_RS14450	COG1053	succinate dehydrogenase
C5B73_RS14500	COG2124	cytochrome p450
C5B73_RS14505	COG0386	Belongs to the glutathione peroxidase family
C5B73_RS14520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B73_RS14525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5B73_RS14535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C5B73_RS14550	COG0577	efflux transmembrane transporter activity
C5B73_RS14550	COG1136	(ABC) transporter
C5B73_RS14565	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C5B73_RS14570	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C5B73_RS14575	COG0714	Associated with various cellular activities
C5B73_RS14595	COG3012	SEC-C Motif Domain Protein
C5B73_RS14610	COG2272	Belongs to the type-B carboxylesterase lipase family
C5B73_RS14625	COG1316	TRANSCRIPTIONal
C5B73_RS14630	COG1091	dTDP-4-dehydrorhamnose reductase activity
C5B73_RS14660	COG1482	cell wall glycoprotein biosynthetic process
C5B73_RS14690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5B73_RS14695	COG0778	Nitroreductase
C5B73_RS14695	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C5B73_RS14705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B73_RS14725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B73_RS14730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5B73_RS14745	COG5002	protein histidine kinase activity
C5B73_RS14750	COG5401	PFAM Sporulation and spore germination
C5B73_RS14760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5B73_RS14765	COG0183	Belongs to the thiolase family
C5B73_RS14770	COG0778	Nitroreductase
C5B73_RS14800	COG0653	protein targeting
C5B73_RS14820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5B73_RS14825	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS14835	COG2135	peptidase activity
C5B73_RS14845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5B73_RS14850	COG1595	DNA-templated transcription, initiation
C5B73_RS14855	COG5662	AntiSigma factor
C5B73_RS14860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5B73_RS14875	COG1597	lipid kinase activity
C5B73_RS14885	COG1515	deoxyribonuclease V activity
C5B73_RS14895	COG0588	phosphoglycerate mutase activity
C5B73_RS14905	COG0513	Belongs to the DEAD box helicase family
C5B73_RS14935	COG2353	YceI-like domain
C5B73_RS14965	COG2223	nitrite transmembrane transporter activity
C5B73_RS14970	COG2186	Transcriptional regulator
C5B73_RS14975	COG2807	transmembrane transport
C5B73_RS14985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B73_RS14985	COG2146	nitrite reductase [NAD(P)H] activity
C5B73_RS14990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B73_RS14990	COG2146	nitrite reductase [NAD(P)H] activity
C5B73_RS15045	COG0640	Transcriptional regulator
C5B73_RS15060	COG1140	nitrate reductase beta subunit
C5B73_RS15075	COG0303	'Molybdopterin
C5B73_RS15090	COG0596	Alpha beta hydrolase
C5B73_RS15115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5B73_RS15150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5B73_RS15165	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5B73_RS15175	COG1615	UPF0182 protein
C5B73_RS15180	COG1388	LysM domain
C5B73_RS15210	COG1120	ATPase activity
C5B73_RS15215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5B73_RS15265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5B73_RS15290	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS15295	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS15310	COG4122	O-methyltransferase activity
C5B73_RS15400	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS15410	COG2177	Part of the ABC transporter FtsEX involved in
C5B73_RS15415	COG2884	Cell division ATP-binding protein ftsE
C5B73_RS15420	COG0668	transmembrane transport
C5B73_RS15425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5B73_RS15435	COG0431	NADPH-dependent FMN reductase
C5B73_RS15440	COG0483	inositol monophosphate 1-phosphatase activity
C5B73_RS15455	COG0514	ATP-dependent DNA helicase (RecQ)
C5B73_RS15480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5B73_RS15510	COG1309	transcriptional regulator
C5B73_RS15525	COG1073	alpha beta
C5B73_RS15580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5B73_RS15615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5B73_RS15620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5B73_RS15630	COG2814	Major facilitator Superfamily
C5B73_RS15645	COG0583	DNA-binding transcription factor activity
C5B73_RS15680	COG1672	PFAM Archaeal ATPase
C5B73_RS15680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C5B73_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS15715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5B73_RS15735	COG0346	lactoylglutathione lyase activity
C5B73_RS15780	COG2815	serine threonine protein kinase
C5B73_RS15780	COG0515	serine threonine protein kinase
C5B73_RS15785	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS15820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS15830	COG0477	Major facilitator Superfamily
C5B73_RS15865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5B73_RS15870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5B73_RS15875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5B73_RS15880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5B73_RS15885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5B73_RS15890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5B73_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS15905	COG0736	holo-[acyl-carrier-protein] synthase activity
C5B73_RS15910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B73_RS15925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS15960	COG0667	Aldo Keto reductase
C5B73_RS15985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5B73_RS16005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS16010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS16015	COG1120	ATPase activity
C5B73_RS16020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS16025	COG4592	Periplasmic binding protein
C5B73_RS16045	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5B73_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS16055	COG3433	isochorismatase activity
C5B73_RS16055	COG1535	isochorismatase
C5B73_RS16065	COG5479	isomerase activity
C5B73_RS16065	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS16070	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5B73_RS16090	COG2873	o-acetylhomoserine
C5B73_RS16105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5B73_RS16110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS16115	COG0385	Bile acid
C5B73_RS16120	COG0477	Major facilitator Superfamily
C5B73_RS16125	COG2076	Multidrug Resistance protein
C5B73_RS16180	COG0314	molybdopterin synthase activity
C5B73_RS16185	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5B73_RS16185	COG0315	cyclic pyranopterin monophosphate synthase activity
C5B73_RS16195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5B73_RS16215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5B73_RS16235	COG1780	Probably involved in ribonucleotide reductase function
C5B73_RS16245	COG1674	ftsk spoiiie
C5B73_RS16250	COG2239	Acts as a magnesium transporter
C5B73_RS16300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5B73_RS16305	COG0560	Phosphoserine phosphatase
C5B73_RS16305	COG3830	Belongs to the UPF0237 family
C5B73_RS16315	COG1119	ATPase activity
C5B73_RS16330	COG2226	methyltransferase
C5B73_RS16345	COG0110	maltose O-acetyltransferase activity
C5B73_RS16350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5B73_RS16365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5B73_RS16375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5B73_RS16385	COG0583	DNA-binding transcription factor activity
C5B73_RS16425	COG0482	sulfurtransferase activity
C5B73_RS16435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5B73_RS16450	COG1053	succinate dehydrogenase
C5B73_RS16475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5B73_RS16480	COG0154	amidase activity
C5B73_RS16500	COG4585	Histidine kinase
C5B73_RS16505	COG2197	response regulator
C5B73_RS16515	COG0577	efflux transmembrane transporter activity
C5B73_RS16515	COG1136	(ABC) transporter
C5B73_RS16520	COG1136	(ABC) transporter
C5B73_RS16530	COG4585	Histidine kinase
C5B73_RS16550	COG0205	6-phosphofructokinase activity
C5B73_RS16555	COG1073	alpha beta
C5B73_RS16560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5B73_RS16575	COG0129	dihydroxy-acid dehydratase activity
C5B73_RS16590	COG0440	acetolactate synthase activity
C5B73_RS16595	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5B73_RS16620	COG2514	catechol 2,3-dioxygenase activity
C5B73_RS16625	COG1917	Cupin 2, conserved barrel domain protein
C5B73_RS16625	COG4977	sequence-specific DNA binding
C5B73_RS16630	COG0542	response to heat
C5B73_RS16690	COG1278	Cold shock
C5B73_RS16695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS16705	COG3541	Predicted nucleotidyltransferase
C5B73_RS16720	COG0473	3-isopropylmalate dehydrogenase activity
C5B73_RS16725	COG2271	Major facilitator Superfamily
C5B73_RS16730	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5B73_RS16735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5B73_RS16765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5B73_RS16770	COG0066	3-isopropylmalate dehydratase activity
C5B73_RS16785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C5B73_RS16790	COG1920	GTP binding
C5B73_RS16795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5B73_RS16800	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5B73_RS16820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5B73_RS16845	COG1024	Enoyl-CoA hydratase
C5B73_RS16855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5B73_RS16860	COG1461	Dihydroxyacetone kinase
C5B73_RS16865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5B73_RS16870	COG3800	Transcriptional regulator
C5B73_RS16870	COG1396	sequence-specific DNA binding
C5B73_RS16880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5B73_RS16890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5B73_RS16905	COG0742	ribosomal rna small subunit methyltransferase
C5B73_RS16910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5B73_RS16930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5B73_RS16935	COG0571	ribonuclease III activity
C5B73_RS16940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5B73_RS16945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS16950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5B73_RS16950	COG1796	DNA polymerase
C5B73_RS16955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5B73_RS16965	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C5B73_RS16970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5B73_RS16975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5B73_RS17010	COG1254	Belongs to the acylphosphatase family
C5B73_RS17020	COG0754	glutathionylspermidine amidase activity
C5B73_RS17025	COG3766	membrane
C5B73_RS17065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C5B73_RS17085	COG0228	four-way junction DNA binding
C5B73_RS17095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5B73_RS17100	COG0336	Belongs to the RNA methyltransferase TrmD family
C5B73_RS17105	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS17110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B73_RS17115	COG2197	response regulator
C5B73_RS17125	COG2183	response to ionizing radiation
C5B73_RS17135	COG0335	large ribosomal subunit rRNA binding
C5B73_RS17145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5B73_RS17155	COG0792	nuclease activity
C5B73_RS17175	COG4974	Belongs to the 'phage' integrase family
C5B73_RS17190	COG4762	Protein conserved in bacteria
C5B73_RS17210	COG0052	Belongs to the universal ribosomal protein uS2 family
C5B73_RS17215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5B73_RS17220	COG0528	UMP kinase activity
C5B73_RS17225	COG0233	cytoplasmic translational termination
C5B73_RS17240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5B73_RS17250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5B73_RS17260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5B73_RS17270	COG0768	penicillin binding
C5B73_RS17280	COG4044	May play a role in the intracellular transport of hydrophobic ligands
C5B73_RS17330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS17375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5B73_RS17385	COG2188	Transcriptional regulator
C5B73_RS17410	COG1492	cobalamin metabolic process
C5B73_RS17425	COG0579	oxidoreductase
C5B73_RS17480	COG1648	precorrin-2 dehydrogenase activity
C5B73_RS17480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5B73_RS17495	COG3022	response to hydroperoxide
C5B73_RS17500	COG0442	prolyl-tRNA aminoacylation
C5B73_RS17505	COG1053	succinate dehydrogenase
C5B73_RS17505	COG3976	FMN-binding domain protein
C5B73_RS17530	COG0779	Required for maturation of 30S ribosomal subunits
C5B73_RS17545	COG0481	GTPase activity
C5B73_RS17545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5B73_RS17555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5B73_RS17560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5B73_RS17570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5B73_RS17580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5B73_RS17615	COG0154	amidase activity
C5B73_RS17625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5B73_RS17650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5B73_RS17655	COG1185	polyribonucleotide nucleotidyltransferase activity
C5B73_RS17665	COG0640	Transcriptional regulator
C5B73_RS17670	COG2814	Major facilitator Superfamily
C5B73_RS17685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5B73_RS17725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B73_RS17755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5B73_RS17765	COG1546	Belongs to the CinA family
C5B73_RS17765	COG1058	Belongs to the CinA family
C5B73_RS17770	COG1396	sequence-specific DNA binding
C5B73_RS17775	COG1842	Phage shock protein A
C5B73_RS17785	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS17800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5B73_RS17840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5B73_RS17855	COG0765	amino acid transport
C5B73_RS17860	COG0765	amino acid transport
C5B73_RS17865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5B73_RS17870	COG1126	abc transporter atp-binding protein
C5B73_RS17875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5B73_RS17885	COG1196	nuclear chromosome segregation
C5B73_RS17895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5B73_RS17910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5B73_RS17920	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS17950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5B73_RS17965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5B73_RS17975	COG1643	Atp-dependent helicase
C5B73_RS18000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B73_RS18005	COG0450	alkyl hydroperoxide reductase
C5B73_RS18015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C5B73_RS18055	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5B73_RS18070	COG2890	protein-(glutamine-N5) methyltransferase activity
C5B73_RS18095	COG1309	transcriptional regulator
C5B73_RS18100	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS18110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5B73_RS18130	COG2197	response regulator
C5B73_RS18135	COG4585	Histidine kinase
C5B73_RS18145	COG0475	glutathione-regulated potassium exporter activity
C5B73_RS18185	COG0756	dUTP diphosphatase activity
C5B73_RS18220	COG0569	domain protein
C5B73_RS18225	COG0531	amino acid
C5B73_RS18230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5B73_RS18240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5B73_RS18255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5B73_RS18280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5B73_RS18305	COG2365	Tyrosine phosphatase family
C5B73_RS18350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5B73_RS18375	COG0659	secondary active sulfate transmembrane transporter activity
C5B73_RS18390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5B73_RS18405	COG1560	Kdo2-lipid A biosynthetic process
C5B73_RS18410	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS18420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C5B73_RS18430	COG1946	Acyl-CoA thioesterase
C5B73_RS18440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C5B73_RS18445	COG0217	transcriptional regulatory protein
C5B73_RS18475	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C5B73_RS18485	COG0583	DNA-binding transcription factor activity
C5B73_RS18490	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5B73_RS18495	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS18505	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C5B73_RS18510	COG0632	four-way junction helicase activity
C5B73_RS18515	COG2255	four-way junction helicase activity
C5B73_RS18535	COG1862	Preprotein translocase
C5B73_RS18545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5B73_RS18550	COG0747	negative chemotaxis
C5B73_RS18555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5B73_RS18560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5B73_RS18630	COG1196	nuclear chromosome segregation
C5B73_RS18630	COG0741	lytic transglycosylase activity
C5B73_RS18630	COG0739	heme binding
C5B73_RS18655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5B73_RS18660	COG0124	histidyl-tRNA synthetase
C5B73_RS18670	COG0039	L-malate dehydrogenase activity
C5B73_RS18675	COG1013	pyruvate-flavodoxin oxidoreductase activity
C5B73_RS18680	COG0674	pyruvate-flavodoxin oxidoreductase activity
C5B73_RS18680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C5B73_RS18690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B73_RS18710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C5B73_RS18735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5B73_RS18740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5B73_RS18750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5B73_RS18755	COG0133	tryptophan synthase activity
C5B73_RS18765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5B73_RS18770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5B73_RS18775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5B73_RS18790	COG2409	Drug exporters of the RND superfamily
C5B73_RS18800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5B73_RS18805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5B73_RS18810	COG2350	Protein conserved in bacteria
C5B73_RS18845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5B73_RS18855	COG1113	amino acid transport
C5B73_RS18865	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5B73_RS18870	COG0540	Belongs to the ATCase OTCase family
C5B73_RS18885	COG0505	Belongs to the CarA family
C5B73_RS18895	COG0284	orotidine-5'-phosphate decarboxylase activity
C5B73_RS18905	COG0194	GDP metabolic process
C5B73_RS18910	COG1758	RNA polymerase activity
C5B73_RS18920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5B73_RS18940	COG1309	transcriptional regulator
C5B73_RS18955	COG0242	peptide deformylase activity
C5B73_RS18960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5B73_RS19000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B73_RS19000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B73_RS19015	COG0405	Gamma-glutamyltransferase
C5B73_RS19025	COG3284	Transcriptional regulator
C5B73_RS19030	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS19040	COG0322	excinuclease ABC activity
C5B73_RS19045	COG1660	Displays ATPase and GTPase activities
C5B73_RS19050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5B73_RS19055	COG1481	regulation of sporulation
C5B73_RS19060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5B73_RS19065	COG0126	phosphoglycerate kinase activity
C5B73_RS19070	COG0149	triose-phosphate isomerase activity
C5B73_RS19085	COG2814	Major facilitator Superfamily
C5B73_RS19095	COG0477	Major facilitator Superfamily
C5B73_RS19105	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS19110	COG2267	carboxylic ester hydrolase activity
C5B73_RS19130	COG1309	transcriptional regulator
C5B73_RS19145	COG3757	hydrolase, family 25
C5B73_RS19155	COG0022	dehydrogenase e1 component
C5B73_RS19180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5B73_RS19185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5B73_RS19190	COG0109	protoheme IX farnesyltransferase activity
C5B73_RS19200	COG1309	transcriptional regulator
C5B73_RS19215	COG3835	regulator
C5B73_RS19220	COG1846	Transcriptional regulator
C5B73_RS19225	COG1764	response to oxidative stress
C5B73_RS19240	COG1131	(ABC) transporter
C5B73_RS19265	COG0396	ATPase activity
C5B73_RS19280	COG2151	metal-sulfur cluster biosynthetic enzyme
C5B73_RS19330	COG2124	cytochrome p450
C5B73_RS19340	COG3559	Exporter of polyketide antibiotics
C5B73_RS19345	COG1131	(ABC) transporter
C5B73_RS19360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5B73_RS19380	COG1376	ErfK ybiS ycfS ynhG family protein
C5B73_RS19390	COG0438	transferase activity, transferring glycosyl groups
C5B73_RS19405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS19415	COG2172	sigma factor antagonist activity
C5B73_RS19425	COG2172	sigma factor antagonist activity
C5B73_RS19430	COG1366	Belongs to the anti-sigma-factor antagonist family
C5B73_RS19435	COG1366	Belongs to the anti-sigma-factor antagonist family
C5B73_RS19440	COG1309	transcriptional regulator
C5B73_RS19460	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5B73_RS19460	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5B73_RS19470	COG3549	Plasmid maintenance system killer
C5B73_RS19525	COG0646	methionine synthase
C5B73_RS19525	COG1410	methionine synthase
C5B73_RS19530	COG0515	serine threonine protein kinase
C5B73_RS19535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5B73_RS19555	COG0140	phosphoribosyl-ATP diphosphatase activity
C5B73_RS19560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5B73_RS19565	COG2855	membrane
C5B73_RS19585	COG1222	aaa ATPase
C5B73_RS19635	COG1309	transcriptional regulator
C5B73_RS19640	COG3804	dihydrodipicolinate reductase
C5B73_RS19695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5B73_RS19700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5B73_RS19705	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C5B73_RS19720	COG2378	regulation of single-species biofilm formation
C5B73_RS19725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5B73_RS19770	COG0300	oxidoreductase activity
C5B73_RS19825	COG2267	carboxylic ester hydrolase activity
C5B73_RS19865	COG2130	NADP-dependent
C5B73_RS19915	COG1309	transcriptional regulator
C5B73_RS19925	COG4585	Histidine kinase
C5B73_RS19930	COG2197	response regulator
C5B73_RS19940	COG1228	amidohydrolase
C5B73_RS19980	COG0739	heme binding
C5B73_RS19985	COG0640	Transcriptional regulator
C5B73_RS20015	COG2837	iron assimilation
C5B73_RS20035	COG0745	RESPONSE REGULATOR receiver
C5B73_RS20040	COG2205	protein histidine kinase activity
C5B73_RS20050	COG4221	oxidoreductase activity
C5B73_RS20080	COG0713	ATP synthesis coupled electron transport
C5B73_RS20090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C5B73_RS20090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5B73_RS20095	COG1034	ATP synthesis coupled electron transport
C5B73_RS20110	COG0649	NAD binding
C5B73_RS20115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5B73_RS20120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5B73_RS20135	COG0583	DNA-binding transcription factor activity
C5B73_RS20140	COG1850	ribulose-bisphosphate carboxylase activity
C5B73_RS20145	COG4451	ribulose bisphosphate carboxylase, small
C5B73_RS20150	COG0464	growth
C5B73_RS20160	COG3954	Phosphoribulokinase
C5B73_RS20165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5B73_RS20175	COG0501	Belongs to the peptidase M48B family
C5B73_RS20230	COG1309	transcriptional regulator
C5B73_RS20290	COG0583	DNA-binding transcription factor activity
C5B73_RS20340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS20355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B73_RS20365	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5B73_RS20390	COG0346	lactoylglutathione lyase activity
C5B73_RS20400	COG3971	2-oxopent-4-enoate hydratase activity
C5B73_RS20405	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C5B73_RS20410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B73_RS20420	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS20450	COG0494	nUDIX hydrolase
C5B73_RS20475	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS20480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS20495	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B73_RS20515	COG0745	RESPONSE REGULATOR receiver
C5B73_RS20520	COG2205	protein histidine kinase activity
C5B73_RS20525	COG0456	acetyltransferase
C5B73_RS20530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5B73_RS20535	COG1917	Cupin 2, conserved barrel domain protein
C5B73_RS20540	COG5285	phytanoyl-CoA dioxygenase
C5B73_RS20580	COG3540	Alkaline phosphatase
C5B73_RS20600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B73_RS20610	COG0640	Transcriptional regulator
C5B73_RS20615	COG2310	stress, protein
C5B73_RS20645	COG0477	Major facilitator Superfamily
C5B73_RS20655	COG2190	(PTS) system
C5B73_RS20660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5B73_RS20665	COG1263	PTS System
C5B73_RS20670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5B73_RS20745	COG0156	8-amino-7-oxononanoate synthase activity
C5B73_RS20785	COG0583	DNA-binding transcription factor activity
C5B73_RS20795	COG2814	Major facilitator Superfamily
C5B73_RS20850	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS20855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B73_RS20870	COG2508	Transcriptional regulator
C5B73_RS20885	COG0783	Belongs to the Dps family
C5B73_RS20890	COG0028	Belongs to the TPP enzyme family
C5B73_RS20930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5B73_RS20940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5B73_RS20940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5B73_RS20955	COG0297	glycogen (starch) synthase activity
C5B73_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS20970	COG0859	PFAM glycosyl transferase family 9
C5B73_RS20975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C5B73_RS20980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C5B73_RS20985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5B73_RS20985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5B73_RS21005	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21010	COG0596	Alpha beta hydrolase
C5B73_RS21015	COG0789	Transcriptional regulator
C5B73_RS21045	COG3285	dna ligase
C5B73_RS21045	COG1793	dna ligase
C5B73_RS21065	COG0243	molybdopterin cofactor binding
C5B73_RS21080	COG3707	response regulator
C5B73_RS21090	COG3546	catalase activity
C5B73_RS21120	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C5B73_RS21125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5B73_RS21175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5B73_RS21235	COG1846	Transcriptional regulator
C5B73_RS21245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5B73_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21275	COG0702	epimerase
C5B73_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21300	COG2072	flavoprotein involved in K transport
C5B73_RS21305	COG0657	acetylesterase activity
C5B73_RS21315	COG0174	glutamine synthetase
C5B73_RS21320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5B73_RS21335	COG1024	Enoyl-CoA hydratase
C5B73_RS21345	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS21350	COG2072	flavoprotein involved in K transport
C5B73_RS21355	COG1607	acyl-coa hydrolase
C5B73_RS21405	COG0531	amino acid
C5B73_RS21430	COG1546	Belongs to the CinA family
C5B73_RS21430	COG1058	Belongs to the CinA family
C5B73_RS21450	COG0531	amino acid
C5B73_RS21455	COG4303	Ethanolamine ammonia lyase large subunit
C5B73_RS21480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5B73_RS21490	COG2205	protein histidine kinase activity
C5B73_RS21510	COG0745	RESPONSE REGULATOR receiver
C5B73_RS21515	COG2205	protein histidine kinase activity
C5B73_RS21525	COG2226	methyltransferase
C5B73_RS21530	COG0667	Aldo Keto reductase
C5B73_RS21535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS21535	COG2226	methyltransferase
C5B73_RS21535	COG3433	isochorismatase activity
C5B73_RS21555	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS21570	COG3321	synthase
C5B73_RS21570	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B73_RS21570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B73_RS21570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B73_RS21575	COG2030	dehydratase
C5B73_RS21580	COG1309	transcriptional regulator
C5B73_RS21605	COG2226	methyltransferase
C5B73_RS21620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B73_RS21630	COG0583	DNA-binding transcription factor activity
C5B73_RS21655	COG0596	Alpha beta hydrolase
C5B73_RS21680	COG1309	transcriptional regulator
C5B73_RS21700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5B73_RS21710	COG0183	Belongs to the thiolase family
C5B73_RS21715	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS21815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B73_RS21830	COG0789	Transcriptional regulator
C5B73_RS21835	COG0693	protein deglycase activity
C5B73_RS21855	COG3629	intracellular signal transduction
C5B73_RS21855	COG3903	Transcriptional regulator
C5B73_RS21870	COG0697	spore germination
C5B73_RS21910	COG0025	NhaP-type Na H and K H
C5B73_RS21945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5B73_RS21975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5B73_RS21990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B73_RS21990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B73_RS21995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5B73_RS22005	COG0167	dihydroorotate dehydrogenase activity
C5B73_RS22065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5B73_RS22070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS22080	COG0667	Aldo Keto reductase
C5B73_RS22085	COG1968	undecaprenyl-diphosphatase activity
C5B73_RS22105	COG0215	cysteine-tRNA ligase activity
C5B73_RS22150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5B73_RS22165	COG1414	Transcriptional regulator
C5B73_RS22190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5B73_RS22235	COG1595	DNA-templated transcription, initiation
C5B73_RS22245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C5B73_RS22255	COG0442	prolyl-tRNA aminoacylation
C5B73_RS22325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B73_RS22335	COG1595	DNA-templated transcription, initiation
C5B73_RS22340	COG0445	tRNA wobble uridine modification
C5B73_RS22345	COG1595	DNA-templated transcription, initiation
C5B73_RS22355	COG1595	DNA-templated transcription, initiation
C5B73_RS22375	COG0154	amidase activity
C5B73_RS22380	COG2723	6-phospho-beta-galactosidase activity
C5B73_RS22445	COG0583	DNA-binding transcription factor activity
C5B73_RS22480	COG5479	isomerase activity
C5B73_RS22480	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS22495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS22505	COG2030	dehydratase
C5B73_RS22560	COG3835	regulator
C5B73_RS22565	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C5B73_RS22575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5B73_RS22595	COG0671	phosphoesterase, PA-phosphatase related
C5B73_RS22600	COG0671	phosphoesterase, PA-phosphatase related
C5B73_RS22605	COG2409	Drug exporters of the RND superfamily
C5B73_RS22615	COG1309	transcriptional regulator
C5B73_RS22625	COG2268	Band 7 protein
C5B73_RS22630	COG1278	Cold shock
C5B73_RS22635	COG1793	dna ligase
C5B73_RS22675	COG0596	Alpha beta hydrolase
C5B73_RS22735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B73_RS22770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C5B73_RS22785	COG2304	oxidoreductase activity
C5B73_RS22795	COG0714	Associated with various cellular activities
C5B73_RS22800	COG0791	NLP P60 protein
C5B73_RS22800	COG3883	PFAM NLP P60 protein
C5B73_RS22810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5B73_RS22815	COG1309	transcriptional regulator
C5B73_RS22855	COG0488	(ABC) transporter
C5B73_RS22865	COG2409	Drug exporters of the RND superfamily
C5B73_RS22890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS22895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS22930	COG1253	flavin adenine dinucleotide binding
C5B73_RS22945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5B73_RS22955	COG1309	transcriptional regulator
C5B73_RS22980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5B73_RS22980	COG1024	Enoyl-CoA hydratase
C5B73_RS23015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5B73_RS23020	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS23025	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS23050	COG4257	antibiotic catabolic process
C5B73_RS23060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5B73_RS23060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5B73_RS23080	COG1716	ATPase activity
C5B73_RS23085	COG0509	glycine decarboxylation via glycine cleavage system
C5B73_RS23120	COG5398	heme oxygenase
C5B73_RS23135	COG1414	Transcriptional regulator
C5B73_RS23155	COG2318	DinB family
C5B73_RS23160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B73_RS23170	COG1119	ATPase activity
C5B73_RS23180	COG2124	cytochrome p450
C5B73_RS23240	COG1960	acyl-CoA dehydrogenase activity
C5B73_RS23250	COG2188	Transcriptional regulator
C5B73_RS23275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5B73_RS23290	COG1140	nitrate reductase beta subunit
C5B73_RS23325	COG3360	Dodecin
C5B73_RS23420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5B73_RS23425	COG0477	Major facilitator Superfamily
C5B73_RS23440	COG3321	synthase
C5B73_RS23440	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS23440	COG0604	alcohol dehydrogenase
C5B73_RS23445	COG2409	Drug exporters of the RND superfamily
C5B73_RS23470	COG0628	permease
C5B73_RS23500	COG2909	trisaccharide binding
C5B73_RS23500	COG2909	trisaccharide binding
C5B73_RS23515	COG0659	secondary active sulfate transmembrane transporter activity
C5B73_RS23535	COG2072	flavoprotein involved in K transport
C5B73_RS23545	COG1024	Enoyl-CoA hydratase
C5B73_RS23590	COG2072	flavoprotein involved in K transport
C5B73_RS23595	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS23640	COG2890	protein-(glutamine-N5) methyltransferase activity
C5B73_RS23665	COG1063	alcohol dehydrogenase
C5B73_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS23680	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS23700	COG0789	Transcriptional regulator
C5B73_RS23705	COG0640	Transcriptional regulator
C5B73_RS23710	COG0798	PFAM Bile acid sodium symporter
C5B73_RS23715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5B73_RS23720	COG1053	succinate dehydrogenase
C5B73_RS23740	COG4221	oxidoreductase activity
C5B73_RS23745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS23790	COG0346	lactoylglutathione lyase activity
C5B73_RS23810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B73_RS23815	COG2072	flavoprotein involved in K transport
C5B73_RS23820	COG1053	succinate dehydrogenase
C5B73_RS23825	COG3631	Ketosteroid isomerase-related protein
C5B73_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS23870	COG2814	Major facilitator Superfamily
C5B73_RS23885	COG3835	regulator
C5B73_RS23910	COG1408	metallophosphoesterase
C5B73_RS23915	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS23930	COG0477	Major facilitator Superfamily
C5B73_RS23935	COG2133	pyrroloquinoline quinone binding
C5B73_RS23965	COG0475	glutathione-regulated potassium exporter activity
C5B73_RS23985	COG0471	metal ion transport
C5B73_RS23985	COG0490	domain, Protein
C5B73_RS24010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5B73_RS24020	COG2890	protein-(glutamine-N5) methyltransferase activity
C5B73_RS24030	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS24040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5B73_RS24045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5B73_RS24050	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS24060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B73_RS24080	COG1595	DNA-templated transcription, initiation
C5B73_RS24095	COG1074	ATP-dependent DNA helicase activity
C5B73_RS24100	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5B73_RS24120	COG1252	NADH dehydrogenase
C5B73_RS24130	COG0477	Major facilitator Superfamily
C5B73_RS24145	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5B73_RS24165	COG0488	(ABC) transporter
C5B73_RS24190	COG1024	Enoyl-CoA hydratase
C5B73_RS24210	COG2364	Membrane
C5B73_RS24215	COG0110	maltose O-acetyltransferase activity
C5B73_RS24315	COG2175	clavaminate synthase activity
C5B73_RS24340	COG2149	membrane
C5B73_RS24355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5B73_RS24360	COG3119	arylsulfatase activity
C5B73_RS24370	COG1309	transcriptional regulator
C5B73_RS24415	COG1309	transcriptional regulator
C5B73_RS24430	COG0596	Alpha beta hydrolase
C5B73_RS24450	COG0657	acetylesterase activity
C5B73_RS24500	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS24550	COG4770	biotin carboxylase activity
C5B73_RS24580	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS24600	COG3795	YCII-related domain
C5B73_RS24605	COG4941	Belongs to the sigma-70 factor family
C5B73_RS24615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B73_RS24630	COG1741	Belongs to the pirin family
C5B73_RS24640	COG0723	plastoquinol--plastocyanin reductase activity
C5B73_RS24640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B73_RS24675	COG2124	cytochrome p450
C5B73_RS24685	COG0583	DNA-binding transcription factor activity
C5B73_RS24700	COG3540	Alkaline phosphatase
C5B73_RS24710	COG0542	response to heat
C5B73_RS24720	COG0436	Aminotransferase
C5B73_RS24725	COG1733	regulation of RNA biosynthetic process
C5B73_RS24750	COG4941	Belongs to the sigma-70 factor family
C5B73_RS24765	COG4106	trans-aconitate 2-methyltransferase activity
C5B73_RS24790	COG2217	Heavy metal translocating P-type atpase
C5B73_RS24820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS24835	COG1573	uracil-dna glycosylase
C5B73_RS24850	COG3707	response regulator
C5B73_RS24880	COG1982	Orn Lys Arg decarboxylase major
C5B73_RS24885	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C5B73_RS24890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5B73_RS24895	COG1349	DNA-binding transcription factor activity
C5B73_RS24905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5B73_RS24905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5B73_RS24905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5B73_RS24915	COG1160	GTP binding
C5B73_RS24920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5B73_RS24925	COG1187	pseudouridine synthase activity
C5B73_RS24930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5B73_RS24950	COG0494	nUDIX hydrolase
C5B73_RS24955	COG0504	CTP synthase activity
C5B73_RS24975	COG3265	gluconokinase activity
C5B73_RS24990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5B73_RS25005	COG0647	UMP catabolic process
C5B73_RS25040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5B73_RS25050	COG2094	Belongs to the DNA glycosylase MPG family
C5B73_RS25055	COG2132	Multicopper oxidase
C5B73_RS25060	COG1131	(ABC) transporter
C5B73_RS25065	COG0842	Transport permease protein
C5B73_RS25070	COG1309	transcriptional regulator
C5B73_RS25075	COG2835	tetraacyldisaccharide 4'-kinase activity
C5B73_RS25075	COG1663	tetraacyldisaccharide 4'-kinase activity
C5B73_RS25095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5B73_RS25105	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C5B73_RS25120	COG2076	Multidrug Resistance protein
C5B73_RS25125	COG0165	Argininosuccinate lyase
C5B73_RS25130	COG0137	argininosuccinate synthase activity
C5B73_RS25145	COG2197	response regulator
C5B73_RS25155	COG0586	Pfam SNARE associated Golgi protein
C5B73_RS25205	COG0732	type I restriction modification DNA specificity domain
C5B73_RS25210	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C5B73_RS25215	COG1438	arginine binding
C5B73_RS25230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5B73_RS25235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5B73_RS25240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5B73_RS25250	COG0475	glutathione-regulated potassium exporter activity
C5B73_RS25250	COG0569	domain protein
C5B73_RS25265	COG4941	Belongs to the sigma-70 factor family
C5B73_RS25280	COG2378	regulation of single-species biofilm formation
C5B73_RS25295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C5B73_RS25340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5B73_RS25340	COG0072	phenylalanine-tRNA ligase activity
C5B73_RS25345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5B73_RS25360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5B73_RS25365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5B73_RS25370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5B73_RS25375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5B73_RS25465	COG0237	dephospho-CoA kinase activity
C5B73_RS25465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5B73_RS25480	COG0539	negative regulation of cytoplasmic translation
C5B73_RS25485	COG2226	methyltransferase
C5B73_RS25515	COG0765	amino acid transport
C5B73_RS25525	COG0473	3-isopropylmalate dehydrogenase activity
C5B73_RS25535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5B73_RS25555	COG0410	ABC transporter
C5B73_RS25600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B73_RS25610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS25615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS25625	COG1116	anion transmembrane transporter activity
C5B73_RS25630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B73_RS25640	COG1414	Transcriptional regulator
C5B73_RS25645	COG0300	oxidoreductase activity
C5B73_RS25670	COG1946	Acyl-CoA thioesterase
C5B73_RS25680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C5B73_RS25685	COG0159	tryptophan synthase activity
C5B73_RS25705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5B73_RS25730	COG0604	alcohol dehydrogenase
C5B73_RS25730	COG3321	synthase
C5B73_RS25740	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS25745	COG0107	imidazoleglycerol-phosphate synthase activity
C5B73_RS25750	COG0483	inositol monophosphate 1-phosphatase activity
C5B73_RS25755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5B73_RS25765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5B73_RS25770	COG0131	Imidazoleglycerol-phosphate dehydratase
C5B73_RS25775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5B73_RS25780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5B73_RS25805	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C5B73_RS25825	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C5B73_RS25860	COG2755	lipolytic protein G-D-S-L family
C5B73_RS25865	COG0583	DNA-binding transcription factor activity
C5B73_RS25875	COG4681	YaeQ
C5B73_RS25905	COG1309	transcriptional regulator
C5B73_RS25910	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS25920	COG2030	dehydratase
C5B73_RS25980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5B73_RS25990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS25995	COG1116	anion transmembrane transporter activity
C5B73_RS26000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B73_RS26015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B73_RS26020	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C5B73_RS26030	COG1846	Transcriptional regulator
C5B73_RS26035	COG0477	Major facilitator Superfamily
C5B73_RS26050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C5B73_RS26055	COG0156	8-amino-7-oxononanoate synthase activity
C5B73_RS26070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5B73_RS26105	COG1309	transcriptional regulator
C5B73_RS26145	COG0488	(ABC) transporter
C5B73_RS26150	COG1309	transcriptional regulator
C5B73_RS26185	COG2226	methyltransferase
C5B73_RS26240	COG3275	phosphorelay sensor kinase activity
C5B73_RS26245	COG3279	Response regulator of the LytR AlgR family
C5B73_RS26255	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5B73_RS26265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5B73_RS26270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B73_RS26300	COG2072	flavoprotein involved in K transport
C5B73_RS26315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5B73_RS26330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5B73_RS26360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5B73_RS26365	COG3883	PFAM NLP P60 protein
C5B73_RS26365	COG0791	NLP P60 protein
C5B73_RS26370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5B73_RS26380	COG3599	regulation of cell shape
C5B73_RS26390	COG1799	cell septum assembly
C5B73_RS26405	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5B73_RS26415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5B73_RS26420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5B73_RS26430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5B73_RS26435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5B73_RS26450	COG0768	penicillin binding
C5B73_RS26460	COG0275	rRNA processing
C5B73_RS26465	COG2001	Belongs to the MraZ family
C5B73_RS26505	COG0463	Glycosyl transferase, family 2
C5B73_RS26510	COG0747	negative chemotaxis
C5B73_RS26520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5B73_RS26535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B73_RS26545	COG0142	geranyltranstransferase activity
C5B73_RS26565	COG1278	Cold shock
C5B73_RS26580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C5B73_RS26605	COG1845	cytochrome c oxidase, subunit III
C5B73_RS26610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5B73_RS26660	COG0003	Pfam Anion-transporting ATPase
C5B73_RS26670	COG1940	carbohydrate kinase activity
C5B73_RS26710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5B73_RS26720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5B73_RS26750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5B73_RS26755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C5B73_RS26765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B73_RS26770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5B73_RS26775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5B73_RS26790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5B73_RS26805	COG1090	epimerase
C5B73_RS26815	COG0321	lipoyl(octanoyl) transferase activity
C5B73_RS26820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5B73_RS26825	COG4152	abc transporter atp-binding protein
C5B73_RS26835	COG5479	isomerase activity
C5B73_RS26835	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C5B73_RS26865	COG1401	restriction endodeoxyribonuclease activity
C5B73_RS26895	COG0515	serine threonine protein kinase
C5B73_RS26990	COG2226	methyltransferase
C5B73_RS27025	COG2072	flavoprotein involved in K transport
C5B73_RS27030	COG4085	toxin activity
C5B73_RS27030	COG1525	nuclease
C5B73_RS27030	COG0737	Belongs to the 5'-nucleotidase family
C5B73_RS27065	COG0640	Transcriptional regulator
C5B73_RS27080	COG1131	(ABC) transporter
C5B73_RS27085	COG2188	Transcriptional regulator
C5B73_RS27135	COG0174	glutamine synthetase
C5B73_RS27160	COG2267	carboxylic ester hydrolase activity
C5B73_RS27185	COG1309	transcriptional regulator
C5B73_RS27190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5B73_RS27205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5B73_RS27260	COG2084	Dehydrogenase
C5B73_RS27270	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C5B73_RS27280	COG0492	ferredoxin-NADP+ reductase activity
C5B73_RS27285	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS27295	COG2267	carboxylic ester hydrolase activity
C5B73_RS27305	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5B73_RS27380	COG2197	response regulator
C5B73_RS27430	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS27445	COG1595	DNA-templated transcription, initiation
C5B73_RS27475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5B73_RS27480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B73_RS27495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5B73_RS27600	COG0512	Glutamine amidotransferase of anthranilate synthase
C5B73_RS27600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5B73_RS27635	COG0789	Transcriptional regulator
C5B73_RS27635	COG4978	Transcriptional regulator
C5B73_RS27660	COG4941	Belongs to the sigma-70 factor family
C5B73_RS27740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5B73_RS27750	COG0745	RESPONSE REGULATOR receiver
C5B73_RS27815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5B73_RS27825	COG1012	belongs to the aldehyde dehydrogenase family
C5B73_RS27860	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS27885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B73_RS27895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B73_RS27905	COG2409	Drug exporters of the RND superfamily
C5B73_RS27985	COG0477	Major facilitator Superfamily
C5B73_RS28000	COG2124	cytochrome p450
C5B73_RS28015	COG1309	transcriptional regulator
C5B73_RS28045	COG0477	Major facilitator Superfamily
C5B73_RS28055	COG0596	Alpha beta hydrolase
C5B73_RS28095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B73_RS28145	COG0358	DNA primase activity
C5B73_RS28150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C5B73_RS28160	COG1309	transcriptional regulator
C5B73_RS28185	COG0640	Transcriptional regulator
C5B73_RS28190	COG0439	Biotin carboxylase
C5B73_RS28195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B73_RS28210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5B73_RS28215	COG0423	glycine-tRNA ligase activity
C5B73_RS28235	COG1309	transcriptional regulator
C5B73_RS28245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5B73_RS28250	COG1381	Involved in DNA repair and RecF pathway recombination
C5B73_RS28275	COG0596	Alpha beta hydrolase
C5B73_RS28325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5B73_RS28340	COG1420	regulation of RNA biosynthetic process
C5B73_RS28345	COG0484	heat shock protein binding
C5B73_RS28365	COG0175	sulfate reduction
C5B73_RS28410	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS28415	COG0443	Heat shock 70 kDa protein
C5B73_RS28420	COG1028	Short-chain dehydrogenase reductase Sdr
C5B73_RS28440	COG3842	ATPase activity
C5B73_RS28445	COG4208	sulfate ABC transporter
C5B73_RS28455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5B73_RS28475	COG3387	PFAM Glycoside hydrolase 15-related
C5B73_RS28490	COG0481	GTPase activity
C5B73_RS28505	COG0268	Binds directly to 16S ribosomal RNA
C5B73_RS28520	COG0667	Aldo Keto reductase
C5B73_RS28555	COG2755	lipolytic protein G-D-S-L family
C5B73_RS28560	COG0406	alpha-ribazole phosphatase activity
C5B73_RS28565	COG0799	negative regulation of ribosome biogenesis
C5B73_RS28570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5B73_RS28580	COG0326	Molecular chaperone. Has ATPase activity
C5B73_RS28595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5B73_RS28605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5B73_RS28610	COG1690	Belongs to the RtcB family
C5B73_RS28620	COG0514	ATP-dependent DNA helicase (RecQ)
C5B73_RS28630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5B73_RS28670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B73_RS28675	COG0318	PFAM AMP-dependent synthetase and ligase
C5B73_RS28700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5B73_RS28705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5B73_RS28710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5B73_RS28720	COG1530	ribonuclease E activity
C5B73_RS28725	COG0105	UTP biosynthetic process
C5B73_RS28740	COG0285	dihydrofolate synthase activity
C5B73_RS28745	COG0525	valine-tRNA ligase activity
C5B73_RS28760	COG0277	FAD linked oxidase domain protein
C5B73_RS28800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5B73_RS28820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5B73_RS28825	COG0740	serine-type endopeptidase activity
C5B73_RS28830	COG0740	serine-type endopeptidase activity
C5B73_RS28835	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5B73_RS28845	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C5B73_RS28850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B73_RS28870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B73_RS28895	COG0515	serine threonine protein kinase
C5B73_RS28910	COG2902	Dehydrogenase
C5B73_RS28935	COG1404	Belongs to the peptidase S8 family
C5B73_RS28975	COG1674	ftsk spoiiie
C5B73_RS28985	COG0464	growth
C5B73_RS29050	COG3953	SLT domain
C5B73_RS29050	COG5280	Phage tail tape measure protein TP901
C5B73_RS29055	COG5280	Phage tail tape measure protein TP901
C5B73_RS29055	COG3953	SLT domain
C5B73_RS29120	COG5001	Diguanylate cyclase
C5B73_RS29130	COG0698	ribose 5-phosphate isomerase
C5B73_RS29140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5B73_RS29145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B73_RS29160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5B73_RS29170	COG0740	serine-type endopeptidase activity
C5B73_RS29175	COG0740	serine-type endopeptidase activity
C5B73_RS29185	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5B73_RS29195	COG0366	Alpha amylase catalytic
C5B73_RS29210	COG1396	sequence-specific DNA binding
C5B73_RS29215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5B73_RS29230	COG0824	Thioesterase
C5B73_RS29235	COG2902	Dehydrogenase
C5B73_RS29250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5B73_RS29270	COG1595	DNA-templated transcription, initiation
C5B73_RS29280	COG1733	regulation of RNA biosynthetic process
C5B73_RS29285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B73_RS29290	COG1309	transcriptional regulator
C5B73_RS29320	COG1902	pentaerythritol trinitrate reductase activity
C5B73_RS29320	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B73_RS29325	COG2050	protein possibly involved in aromatic compounds catabolism