locus-tag	class	description
CRH09_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRH09_RS00010	COG0592	DNA-directed DNA polymerase activity
CRH09_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRH09_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CRH09_RS00025	COG0187	DNA topoisomerase II activity
CRH09_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRH09_RS00150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CRH09_RS00165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRH09_RS00200	COG0515	serine threonine protein kinase
CRH09_RS00200	COG2815	serine threonine protein kinase
CRH09_RS00205	COG0515	serine threonine protein kinase
CRH09_RS00210	COG0768	penicillin binding
CRH09_RS00225	COG1716	ATPase activity
CRH09_RS00230	COG1716	ATPase activity
CRH09_RS00245	COG0704	Plays a role in the regulation of phosphate uptake
CRH09_RS00270	COG0714	Associated with various cellular activities
CRH09_RS00290	COG0477	Major facilitator Superfamily
CRH09_RS00295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRH09_RS00305	COG2124	cytochrome p450
CRH09_RS00320	COG0069	glutamate synthase activity
CRH09_RS00320	COG0070	glutamate synthase
CRH09_RS00320	COG0067	glutamate synthase
CRH09_RS00330	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRH09_RS00350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRH09_RS00350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CRH09_RS00355	COG2501	S4 domain
CRH09_RS00360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CRH09_RS00370	COG1276	copper resistance
CRH09_RS00400	COG0326	Molecular chaperone. Has ATPase activity
CRH09_RS00420	COG2119	membrane
CRH09_RS00545	COG0425	Belongs to the sulfur carrier protein TusA family
CRH09_RS00545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRH09_RS00565	COG1528	Iron-storage protein
CRH09_RS00570	COG1528	Iron-storage protein
CRH09_RS00575	COG1316	TRANSCRIPTIONal
CRH09_RS00600	COG0077	Prephenate dehydratase
CRH09_RS00635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRH09_RS00640	COG3300	MHYT domain
CRH09_RS00640	COG5001	Diguanylate cyclase
CRH09_RS00650	COG0673	inositol 2-dehydrogenase activity
CRH09_RS00665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRH09_RS00665	COG2146	nitrite reductase [NAD(P)H] activity
CRH09_RS00675	COG0204	Acyl-transferase
CRH09_RS00685	COG0477	Major facilitator Superfamily
CRH09_RS00695	COG2957	Belongs to the agmatine deiminase family
CRH09_RS00725	COG0561	phosphatase activity
CRH09_RS00735	COG2385	sporulation resulting in formation of a cellular spore
CRH09_RS00740	COG1846	Transcriptional regulator
CRH09_RS00770	COG1216	Glycosyl transferase, family 2
CRH09_RS00780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CRH09_RS00785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS00790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CRH09_RS00795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CRH09_RS00820	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRH09_RS00825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS00830	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS00835	COG3321	synthase
CRH09_RS00835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS00835	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CRH09_RS00840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRH09_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS00880	COG0277	FAD linked oxidase domain protein
CRH09_RS00890	COG0243	molybdopterin cofactor binding
CRH09_RS00910	COG1846	Transcriptional regulator
CRH09_RS00965	COG1216	Glycosyl transferase, family 2
CRH09_RS00970	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS00975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRH09_RS00980	COG1162	GTPase activity
CRH09_RS00985	COG1216	Glycosyl transferase, family 2
CRH09_RS01035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CRH09_RS01045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH09_RS01090	COG0270	DNA (cytosine-5-)-methyltransferase activity
CRH09_RS01110	COG1132	(ABC) transporter
CRH09_RS01115	COG1132	(ABC) transporter
CRH09_RS01125	COG0287	Prephenate dehydrogenase
CRH09_RS01135	COG0590	tRNA wobble adenosine to inosine editing
CRH09_RS01215	COG2409	Drug exporters of the RND superfamily
CRH09_RS01240	COG0343	queuine tRNA-ribosyltransferase activity
CRH09_RS01260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRH09_RS01320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CRH09_RS01325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS01330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRH09_RS01390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS01395	COG0494	nUDIX hydrolase
CRH09_RS01400	COG3706	GGDEF domain
CRH09_RS01405	COG0667	Aldo Keto reductase
CRH09_RS01410	COG1733	regulation of RNA biosynthetic process
CRH09_RS01415	COG1733	regulation of RNA biosynthetic process
CRH09_RS01435	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS01485	COG5183	chlorophyll binding
CRH09_RS01485	COG2133	pyrroloquinoline quinone binding
CRH09_RS01530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS01930	COG0582	viral genome integration into host DNA
CRH09_RS01950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS02005	COG1116	anion transmembrane transporter activity
CRH09_RS02010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRH09_RS02075	COG1126	abc transporter atp-binding protein
CRH09_RS02090	COG0601	transmembrane transport
CRH09_RS02095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS02110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS02120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS02125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS02150	COG2321	neutral zinc metallopeptidase
CRH09_RS02165	COG2409	Drug exporters of the RND superfamily
CRH09_RS02185	COG0183	Belongs to the thiolase family
CRH09_RS02190	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRH09_RS02190	COG1024	Enoyl-CoA hydratase
CRH09_RS02200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRH09_RS02220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRH09_RS02225	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRH09_RS02230	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS02255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRH09_RS02270	COG0697	spore germination
CRH09_RS02275	COG1233	COG1233 Phytoene dehydrogenase and related
CRH09_RS02285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRH09_RS02330	COG0432	Pfam Uncharacterised protein family UPF0047
CRH09_RS02335	COG1846	Transcriptional regulator
CRH09_RS02370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRH09_RS02400	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CRH09_RS02405	COG0386	Belongs to the glutathione peroxidase family
CRH09_RS02445	COG4689	acetoacetate decarboxylase
CRH09_RS02450	COG0300	oxidoreductase activity
CRH09_RS02455	COG1024	Enoyl-CoA hydratase
CRH09_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS02515	COG1408	metallophosphoesterase
CRH09_RS02525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CRH09_RS02555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS02590	COG0596	Alpha beta hydrolase
CRH09_RS02600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRH09_RS02605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRH09_RS02615	COG0601	transmembrane transport
CRH09_RS02620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS02625	COG4172	Belongs to the ABC transporter superfamily
CRH09_RS02675	COG1111	helicase
CRH09_RS02675	COG1205	dead DEAH box helicase
CRH09_RS02685	COG1754	DNA topoisomerase type I activity
CRH09_RS02685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRH09_RS02690	COG2318	DinB family
CRH09_RS02695	COG0470	DNA polymerase III
CRH09_RS02780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRH09_RS02785	COG0442	prolyl-tRNA aminoacylation
CRH09_RS02795	COG1024	Enoyl-CoA hydratase
CRH09_RS02800	COG3903	Transcriptional regulator
CRH09_RS02800	COG3629	intracellular signal transduction
CRH09_RS02810	COG2027	D-alanyl-D-alanine carboxypeptidase
CRH09_RS02820	COG0037	tRNA processing
CRH09_RS02830	COG0583	DNA-binding transcription factor activity
CRH09_RS02845	COG2815	serine threonine protein kinase
CRH09_RS02845	COG0515	serine threonine protein kinase
CRH09_RS02870	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS02895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRH09_RS02900	COG0302	gtp cyclohydrolase
CRH09_RS02905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRH09_RS02910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CRH09_RS02935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CRH09_RS02940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CRH09_RS02945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CRH09_RS02960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRH09_RS02995	COG2197	response regulator
CRH09_RS03000	COG4585	Histidine kinase
CRH09_RS03020	COG1554	hydrolase, family 65, central catalytic
CRH09_RS03035	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03040	COG1024	Enoyl-CoA hydratase
CRH09_RS03050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRH09_RS03055	COG0215	cysteine-tRNA ligase activity
CRH09_RS03060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CRH09_RS03065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CRH09_RS03075	COG2847	Copper chaperone PCu(A)C
CRH09_RS03080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CRH09_RS03100	COG1194	a g-specific adenine glycosylase
CRH09_RS03105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRH09_RS03110	COG3842	ATPase activity
CRH09_RS03120	COG3387	PFAM Glycoside hydrolase 15-related
CRH09_RS03125	COG1309	transcriptional regulator
CRH09_RS03130	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03135	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03140	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03145	COG2030	dehydratase
CRH09_RS03170	COG0714	Associated with various cellular activities
CRH09_RS03185	COG2030	dehydratase
CRH09_RS03190	COG1053	succinate dehydrogenase
CRH09_RS03195	COG3971	2-oxopent-4-enoate hydratase activity
CRH09_RS03200	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CRH09_RS03205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRH09_RS03210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS03240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS03250	COG4829	muconolactone delta-isomerase
CRH09_RS03260	COG0300	oxidoreductase activity
CRH09_RS03290	COG1024	Enoyl-CoA hydratase
CRH09_RS03300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRH09_RS03305	COG0346	lactoylglutathione lyase activity
CRH09_RS03310	COG2267	carboxylic ester hydrolase activity
CRH09_RS03315	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03355	COG1113	amino acid transport
CRH09_RS03360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS03365	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03370	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03375	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03385	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS03390	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03405	COG1309	transcriptional regulator
CRH09_RS03410	COG0183	Belongs to the thiolase family
CRH09_RS03415	COG0243	molybdopterin cofactor binding
CRH09_RS03435	COG1024	Enoyl-CoA hydratase
CRH09_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS03470	COG0183	Belongs to the thiolase family
CRH09_RS03475	COG2124	cytochrome p450
CRH09_RS03500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS03530	COG0667	Aldo Keto reductase
CRH09_RS03535	COG0529	Catalyzes the synthesis of activated sulfate
CRH09_RS03540	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03545	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS03565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS03590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRH09_RS03610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CRH09_RS03630	COG0745	RESPONSE REGULATOR receiver
CRH09_RS03635	COG5002	protein histidine kinase activity
CRH09_RS03640	COG0537	adenosine 5'-monophosphoramidase activity
CRH09_RS03655	COG0436	Aminotransferase
CRH09_RS03665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRH09_RS03670	COG0537	adenosine 5'-monophosphoramidase activity
CRH09_RS03705	COG0076	glutamate decarboxylase activity
CRH09_RS03720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRH09_RS03725	COG0047	phosphoribosylformylglycinamidine synthase activity
CRH09_RS03740	COG1362	aminopeptidase activity
CRH09_RS03745	COG5650	phosphatidylinositol metabolic process
CRH09_RS03750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRH09_RS03780	COG4166	transmembrane transport
CRH09_RS03785	COG0601	transmembrane transport
CRH09_RS03790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS03805	COG0596	Alpha beta hydrolase
CRH09_RS03810	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRH09_RS03830	COG0354	folic acid binding
CRH09_RS03840	COG1271	oxidase subunit
CRH09_RS03845	COG1294	oxidase, subunit
CRH09_RS03850	COG4988	ABC transporter
CRH09_RS03855	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CRH09_RS03860	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CRH09_RS03870	COG2897	thiosulfate sulfurtransferase activity
CRH09_RS03880	COG0492	ferredoxin-NADP+ reductase activity
CRH09_RS03880	COG3118	belongs to the thioredoxin family
CRH09_RS03890	COG0745	RESPONSE REGULATOR receiver
CRH09_RS03895	COG0454	-acetyltransferase
CRH09_RS03895	COG0456	acetyltransferase
CRH09_RS03910	COG0581	inorganic phosphate transmembrane transporter activity
CRH09_RS03915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRH09_RS03995	COG1169	isochorismate synthase
CRH09_RS04000	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRH09_RS04005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS04005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CRH09_RS04010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CRH09_RS04025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CRH09_RS04030	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS04050	COG1129	ABC transporter
CRH09_RS04055	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS04060	COG1879	ABC-type sugar transport system periplasmic component
CRH09_RS04065	COG1595	DNA-templated transcription, initiation
CRH09_RS04120	COG1278	Cold shock
CRH09_RS04130	COG2814	Major facilitator Superfamily
CRH09_RS04160	COG1846	Transcriptional regulator
CRH09_RS04190	COG0259	pyridoxamine-phosphate oxidase activity
CRH09_RS04210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CRH09_RS04235	COG0545	Peptidyl-prolyl cis-trans isomerase
CRH09_RS04245	COG2205	protein histidine kinase activity
CRH09_RS04270	COG2018	Roadblock/LC7 domain
CRH09_RS04305	COG0656	L-ascorbic acid biosynthetic process
CRH09_RS04310	COG2072	flavoprotein involved in K transport
CRH09_RS04315	COG1024	Enoyl-CoA hydratase
CRH09_RS04370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRH09_RS04395	COG0564	pseudouridine synthase activity
CRH09_RS04405	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS04430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS04465	COG4977	sequence-specific DNA binding
CRH09_RS04470	COG0531	amino acid
CRH09_RS04535	COG1228	amidohydrolase
CRH09_RS04540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRH09_RS04585	COG0596	Alpha beta hydrolase
CRH09_RS04590	COG0519	Catalyzes the synthesis of GMP from XMP
CRH09_RS04610	COG1136	(ABC) transporter
CRH09_RS04630	COG4221	oxidoreductase activity
CRH09_RS04685	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS04690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRH09_RS04690	COG0574	Belongs to the PEP-utilizing enzyme family
CRH09_RS04735	COG3135	benzoate transporter
CRH09_RS04755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH09_RS04770	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS04785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS04810	COG4585	Histidine kinase
CRH09_RS04825	COG0300	oxidoreductase activity
CRH09_RS04860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS04875	COG0596	Alpha beta hydrolase
CRH09_RS04895	COG2072	flavoprotein involved in K transport
CRH09_RS04900	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS04905	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS04915	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS04945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS04995	COG1309	transcriptional regulator
CRH09_RS05015	COG0644	oxidoreductase
CRH09_RS05055	COG0051	transcription antitermination factor activity, RNA binding
CRH09_RS05060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRH09_RS05065	COG0088	Forms part of the polypeptide exit tunnel
CRH09_RS05070	COG0089	rRNA binding
CRH09_RS05075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CRH09_RS05085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CRH09_RS05090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRH09_RS05095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRH09_RS05100	COG0255	Belongs to the universal ribosomal protein uL29 family
CRH09_RS05105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRH09_RS05130	COG1809	phosphosulfolactate synthase activity
CRH09_RS05140	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS05170	COG0564	pseudouridine synthase activity
CRH09_RS05195	COG3321	synthase
CRH09_RS05205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS05230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRH09_RS05270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS05290	COG0028	Belongs to the TPP enzyme family
CRH09_RS05295	COG0577	efflux transmembrane transporter activity
CRH09_RS05295	COG1136	(ABC) transporter
CRH09_RS05330	COG3590	peptidase
CRH09_RS05335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRH09_RS05340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRH09_RS05345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRH09_RS05350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRH09_RS05365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRH09_RS05370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRH09_RS05375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRH09_RS05380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRH09_RS05385	COG1841	ribosomal large subunit assembly
CRH09_RS05390	COG0200	Binds to the 23S rRNA
CRH09_RS05395	COG0201	protein transport
CRH09_RS05400	COG0563	adenylate kinase activity
CRH09_RS05420	COG1490	D-aminoacyl-tRNA deacylase activity
CRH09_RS05445	COG0745	RESPONSE REGULATOR receiver
CRH09_RS05450	COG0443	Heat shock 70 kDa protein
CRH09_RS05560	COG0464	growth
CRH09_RS05570	COG1404	Belongs to the peptidase S8 family
CRH09_RS05575	COG1674	ftsk spoiiie
CRH09_RS05585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS05600	COG0477	Major facilitator Superfamily
CRH09_RS05605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRH09_RS05610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRH09_RS05615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CRH09_RS05620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRH09_RS05625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRH09_RS05630	COG0202	RNA polymerase activity
CRH09_RS05635	COG0203	ribosomal protein L17
CRH09_RS05640	COG0101	tRNA pseudouridine synthase activity
CRH09_RS05650	COG1937	Protein conserved in bacteria
CRH09_RS05655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CRH09_RS05685	COG2814	Major facilitator Superfamily
CRH09_RS05690	COG0681	Belongs to the peptidase S26 family
CRH09_RS05705	COG1404	Belongs to the peptidase S8 family
CRH09_RS05715	COG1674	ftsk spoiiie
CRH09_RS05765	COG0596	Alpha beta hydrolase
CRH09_RS05770	COG1408	metallophosphoesterase
CRH09_RS05790	COG0842	Transport permease protein
CRH09_RS05790	COG1131	(ABC) transporter
CRH09_RS05790	COG1716	ATPase activity
CRH09_RS05800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRH09_RS05805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRH09_RS05810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRH09_RS05830	COG0488	(ABC) transporter
CRH09_RS05835	COG1983	PspC domain protein
CRH09_RS05870	COG2814	Major facilitator Superfamily
CRH09_RS05910	COG1214	PFAM Peptidase M22, glycoprotease
CRH09_RS05910	COG0456	acetyltransferase
CRH09_RS05915	COG0456	acetyltransferase
CRH09_RS05920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRH09_RS05930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRH09_RS05935	COG0459	protein refolding
CRH09_RS05945	COG1595	DNA-templated transcription, initiation
CRH09_RS05975	COG0517	IMP dehydrogenase activity
CRH09_RS05975	COG0516	GMP reductase activity
CRH09_RS05980	COG0516	GMP reductase activity
CRH09_RS05990	COG0519	Catalyzes the synthesis of GMP from XMP
CRH09_RS05990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRH09_RS06010	COG4585	Histidine kinase
CRH09_RS06020	COG0515	serine threonine protein kinase
CRH09_RS06020	COG2815	serine threonine protein kinase
CRH09_RS06070	COG4221	oxidoreductase activity
CRH09_RS06075	COG0587	DNA-directed DNA polymerase activity
CRH09_RS06100	COG1872	DUF167
CRH09_RS06105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRH09_RS06115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRH09_RS06130	COG2814	Major facilitator Superfamily
CRH09_RS06140	COG0183	Belongs to the thiolase family
CRH09_RS06155	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS06160	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS06175	COG0739	heme binding
CRH09_RS06275	COG0708	Exodeoxyribonuclease III
CRH09_RS06295	COG0180	Tryptophanyl-tRNA synthetase
CRH09_RS06300	COG1295	ribonuclease BN
CRH09_RS06305	COG1686	Belongs to the peptidase S11 family
CRH09_RS06310	COG0477	Major facilitator Superfamily
CRH09_RS06315	COG1309	transcriptional regulator
CRH09_RS06330	COG1053	succinate dehydrogenase
CRH09_RS06340	COG2009	succinate dehydrogenase
CRH09_RS06375	COG0791	NLP P60 protein
CRH09_RS06375	COG3883	PFAM NLP P60 protein
CRH09_RS06385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRH09_RS06390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CRH09_RS06400	COG1234	tRNA 3'-trailer cleavage
CRH09_RS06405	COG1024	Enoyl-CoA hydratase
CRH09_RS06405	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRH09_RS06415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CRH09_RS06415	COG1473	amidohydrolase
CRH09_RS06440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS06445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRH09_RS06460	COG1309	transcriptional regulator
CRH09_RS06465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS06465	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CRH09_RS06470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRH09_RS06475	COG1201	RNA secondary structure unwinding
CRH09_RS06495	COG0300	oxidoreductase activity
CRH09_RS06500	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS06505	COG1522	sequence-specific DNA binding
CRH09_RS06520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRH09_RS06530	COG0424	maF-like protein
CRH09_RS06545	COG4770	biotin carboxylase activity
CRH09_RS06580	COG0745	RESPONSE REGULATOR receiver
CRH09_RS06585	COG2205	protein histidine kinase activity
CRH09_RS06625	COG0277	FAD linked oxidase domain protein
CRH09_RS06635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRH09_RS06640	COG0477	Major facilitator Superfamily
CRH09_RS06645	COG1309	transcriptional regulator
CRH09_RS06680	COG2706	6-phosphogluconolactonase activity
CRH09_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS06700	COG1309	transcriptional regulator
CRH09_RS06715	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH09_RS06720	COG0022	dehydrogenase e1 component
CRH09_RS06735	COG3135	benzoate transporter
CRH09_RS06755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CRH09_RS06790	COG1703	isobutyryl-CoA mutase activity
CRH09_RS06790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRH09_RS06790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CRH09_RS06820	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS06825	COG1024	Enoyl-CoA hydratase
CRH09_RS06850	COG0443	Heat shock 70 kDa protein
CRH09_RS06880	COG3842	ATPase activity
CRH09_RS06960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRH09_RS07005	COG0018	arginyl-trna synthetase
CRH09_RS07010	COG0019	diaminopimelate decarboxylase activity
CRH09_RS07015	COG0460	homoserine dehydrogenase
CRH09_RS07020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRH09_RS07025	COG0083	homoserine kinase activity
CRH09_RS07040	COG0254	rRNA binding
CRH09_RS07045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRH09_RS07050	COG2890	protein-(glutamine-N5) methyltransferase activity
CRH09_RS07060	COG1129	ABC transporter
CRH09_RS07060	COG0842	Transport permease protein
CRH09_RS07070	COG0009	L-threonylcarbamoyladenylate synthase
CRH09_RS07075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRH09_RS07085	COG0356	it plays a direct role in the translocation of protons across the membrane
CRH09_RS07090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRH09_RS07095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRH09_RS07100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRH09_RS07105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CRH09_RS07110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRH09_RS07115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRH09_RS07120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRH09_RS07135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CRH09_RS07160	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CRH09_RS07175	COG0346	lactoylglutathione lyase activity
CRH09_RS07180	COG0183	Belongs to the thiolase family
CRH09_RS07195	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CRH09_RS07200	COG0366	Alpha amylase catalytic
CRH09_RS07210	COG0058	SHG alpha-glucan phosphorylase activity
CRH09_RS07215	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS07220	COG2252	PERMEase
CRH09_RS07235	COG1335	isochorismatase
CRH09_RS07240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CRH09_RS07245	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CRH09_RS07275	COG1234	tRNA 3'-trailer cleavage
CRH09_RS07280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CRH09_RS07285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRH09_RS07325	COG2040	homocysteine
CRH09_RS07370	COG2364	Membrane
CRH09_RS07375	COG0180	Tryptophanyl-tRNA synthetase
CRH09_RS07430	COG0387	Pfam Sodium calcium exchanger
CRH09_RS07450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS07495	COG0706	membrane insertase activity
CRH09_RS07510	COG0235	Class ii aldolase
CRH09_RS07515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRH09_RS07530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRH09_RS07555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRH09_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS07615	COG2353	YceI-like domain
CRH09_RS07640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRH09_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS07765	COG1131	(ABC) transporter
CRH09_RS07775	COG3180	Ammonia monooxygenase
CRH09_RS07780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRH09_RS07800	COG1063	alcohol dehydrogenase
CRH09_RS07850	COG1309	transcriptional regulator
CRH09_RS07855	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS07865	COG1022	Amp-dependent synthetase and ligase
CRH09_RS07865	COG3320	Male sterility
CRH09_RS07895	COG0789	Transcriptional regulator
CRH09_RS07940	COG0667	Aldo Keto reductase
CRH09_RS08060	COG2079	MmgE PrpD family protein
CRH09_RS08070	COG2301	Belongs to the HpcH HpaI aldolase family
CRH09_RS08075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRH09_RS08080	COG2272	Belongs to the type-B carboxylesterase lipase family
CRH09_RS08215	COG1819	glycosyl
CRH09_RS08220	COG2124	cytochrome p450
CRH09_RS08245	COG2267	carboxylic ester hydrolase activity
CRH09_RS08250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CRH09_RS08310	COG1053	succinate dehydrogenase
CRH09_RS08315	COG0431	NADPH-dependent FMN reductase
CRH09_RS08330	COG0114	fumarate hydratase activity
CRH09_RS08340	COG0662	Cupin 2, conserved barrel domain protein
CRH09_RS08340	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CRH09_RS08400	COG1073	alpha beta
CRH09_RS08460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CRH09_RS08470	COG2226	methyltransferase
CRH09_RS08475	COG2409	Drug exporters of the RND superfamily
CRH09_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS08505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRH09_RS08520	COG0488	(ABC) transporter
CRH09_RS08555	COG0736	holo-[acyl-carrier-protein] synthase activity
CRH09_RS08590	COG0154	amidase activity
CRH09_RS08605	COG2197	response regulator
CRH09_RS08610	COG3850	Histidine kinase
CRH09_RS08640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRH09_RS08665	COG2814	Major facilitator Superfamily
CRH09_RS08675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRH09_RS08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS08760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRH09_RS08770	COG1473	amidohydrolase
CRH09_RS08795	COG0367	asparagine synthase
CRH09_RS08815	COG0456	acetyltransferase
CRH09_RS08820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS08825	COG5285	phytanoyl-CoA dioxygenase
CRH09_RS08835	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS08840	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS08850	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRH09_RS08860	COG0402	S-adenosylhomocysteine deaminase activity
CRH09_RS08865	COG3483	tryptophan 2,3-dioxygenase activity
CRH09_RS08890	COG0477	Major facilitator Superfamily
CRH09_RS08900	COG3844	kynureninase activity
CRH09_RS08940	COG2828	Protein conserved in bacteria
CRH09_RS09000	COG1376	ErfK ybiS ycfS ynhG family protein
CRH09_RS09010	COG0395	ABC-type sugar transport system, permease component
CRH09_RS09025	COG0433	COG0433 Predicted ATPase
CRH09_RS09030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CRH09_RS09040	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS09055	COG3629	intracellular signal transduction
CRH09_RS09055	COG3903	Transcriptional regulator
CRH09_RS09080	COG0667	Aldo Keto reductase
CRH09_RS09085	COG2814	Major facilitator Superfamily
CRH09_RS09090	COG0640	Transcriptional regulator
CRH09_RS09105	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS09120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CRH09_RS09125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRH09_RS09160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS09170	COG1846	Transcriptional regulator
CRH09_RS09180	COG0300	oxidoreductase activity
CRH09_RS09195	COG1902	pentaerythritol trinitrate reductase activity
CRH09_RS09195	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRH09_RS09245	COG1131	(ABC) transporter
CRH09_RS09260	COG4213	ABC transporter substrate-binding protein
CRH09_RS09270	COG4214	carbohydrate transport
CRH09_RS09275	COG1940	carbohydrate kinase activity
CRH09_RS09280	COG0583	DNA-binding transcription factor activity
CRH09_RS09285	COG0024	Methionine aminopeptidase
CRH09_RS09305	COG2814	Major facilitator Superfamily
CRH09_RS09345	COG2814	Major facilitator Superfamily
CRH09_RS09365	COG4266	Belongs to the allantoicase family
CRH09_RS09370	COG1929	Belongs to the glycerate kinase type-1 family
CRH09_RS09375	COG3960	tartronate-semialdehyde synthase activity
CRH09_RS09380	COG2084	Dehydrogenase
CRH09_RS09385	COG3622	Belongs to the hyi family
CRH09_RS09405	COG2233	PERMEase
CRH09_RS09410	COG1414	Transcriptional regulator
CRH09_RS09425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS09440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS09455	COG0583	DNA-binding transcription factor activity
CRH09_RS09465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRH09_RS09505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRH09_RS09525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRH09_RS09535	COG0475	glutathione-regulated potassium exporter activity
CRH09_RS09550	COG1231	oxidoreductase activity
CRH09_RS09560	COG2030	dehydratase
CRH09_RS09575	COG2161	toxin-antitoxin pair type II binding
CRH09_RS09580	COG2026	Addiction module toxin, RelE StbE family
CRH09_RS09585	COG0392	lysyltransferase activity
CRH09_RS09585	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CRH09_RS09590	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS09620	COG2409	Drug exporters of the RND superfamily
CRH09_RS09670	COG1021	2,3-dihydroxybenzoate-AMP ligase
CRH09_RS09675	COG1169	isochorismate synthase
CRH09_RS09715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRH09_RS09735	COG2902	Dehydrogenase
CRH09_RS09760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CRH09_RS09765	COG1396	sequence-specific DNA binding
CRH09_RS09790	COG0366	Alpha amylase catalytic
CRH09_RS09815	COG1396	sequence-specific DNA binding
CRH09_RS09820	COG0740	serine-type endopeptidase activity
CRH09_RS09825	COG0740	serine-type endopeptidase activity
CRH09_RS09835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CRH09_RS09845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRH09_RS09855	COG0698	ribose 5-phosphate isomerase
CRH09_RS09870	COG5001	Diguanylate cyclase
CRH09_RS09890	COG2205	protein histidine kinase activity
CRH09_RS09900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS09900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS09905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CRH09_RS09925	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRH09_RS09930	COG0740	serine-type endopeptidase activity
CRH09_RS09935	COG0740	serine-type endopeptidase activity
CRH09_RS09940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRH09_RS09965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRH09_RS09980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRH09_RS10015	COG1846	Transcriptional regulator
CRH09_RS10020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CRH09_RS10025	COG4221	oxidoreductase activity
CRH09_RS10045	COG0277	FAD linked oxidase domain protein
CRH09_RS10070	COG0525	valine-tRNA ligase activity
CRH09_RS10075	COG0285	dihydrofolate synthase activity
CRH09_RS10085	COG0105	UTP biosynthetic process
CRH09_RS10090	COG1530	ribonuclease E activity
CRH09_RS10100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRH09_RS10105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRH09_RS10110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CRH09_RS10135	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS10140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS10185	COG2124	cytochrome p450
CRH09_RS10195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRH09_RS10235	COG0477	Major facilitator Superfamily
CRH09_RS10240	COG4977	sequence-specific DNA binding
CRH09_RS10255	COG1070	Carbohydrate kinase
CRH09_RS10260	COG1063	alcohol dehydrogenase
CRH09_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS10275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRH09_RS10295	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS10305	COG2423	ornithine cyclodeaminase activity
CRH09_RS10315	COG2936	dipeptidyl-peptidase activity
CRH09_RS10325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRH09_RS10355	COG2318	DinB family
CRH09_RS10375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRH09_RS10385	COG1414	Transcriptional regulator
CRH09_RS10405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRH09_RS10410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRH09_RS10435	COG3344	reverse transcriptase
CRH09_RS10485	COG0542	response to heat
CRH09_RS10510	COG0799	negative regulation of ribosome biogenesis
CRH09_RS10520	COG2755	lipolytic protein G-D-S-L family
CRH09_RS10575	COG0477	Major facilitator Superfamily
CRH09_RS10580	COG4766	ethanolamine catabolic process
CRH09_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS10595	COG0268	Binds directly to 16S ribosomal RNA
CRH09_RS10600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRH09_RS10610	COG0481	GTPase activity
CRH09_RS10625	COG3387	PFAM Glycoside hydrolase 15-related
CRH09_RS10650	COG4208	sulfate ABC transporter
CRH09_RS10655	COG3842	ATPase activity
CRH09_RS10685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS10700	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS10710	COG0561	phosphatase activity
CRH09_RS10720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRH09_RS10720	COG2022	thiamine diphosphate biosynthetic process
CRH09_RS10735	COG3938	Belongs to the proline racemase family
CRH09_RS10740	COG1802	Transcriptional regulator
CRH09_RS10775	COG1420	regulation of RNA biosynthetic process
CRH09_RS10780	COG0484	heat shock protein binding
CRH09_RS10805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS10810	COG0395	ABC-type sugar transport system, permease component
CRH09_RS10815	COG1175	transmembrane transport
CRH09_RS10890	COG0187	DNA topoisomerase II activity
CRH09_RS10895	COG2814	Major facilitator Superfamily
CRH09_RS10900	COG0583	DNA-binding transcription factor activity
CRH09_RS10910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CRH09_RS10930	COG1953	Uracil, thiamine, allantoin
CRH09_RS10950	COG1309	transcriptional regulator
CRH09_RS10955	COG1381	Involved in DNA repair and RecF pathway recombination
CRH09_RS10970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CRH09_RS10990	COG0423	glycine-tRNA ligase activity
CRH09_RS11000	COG0583	DNA-binding transcription factor activity
CRH09_RS11005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRH09_RS11015	COG1131	(ABC) transporter
CRH09_RS11025	COG4585	Histidine kinase
CRH09_RS11030	COG2197	response regulator
CRH09_RS11035	COG0346	lactoylglutathione lyase activity
CRH09_RS11040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS11050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CRH09_RS11115	COG1201	RNA secondary structure unwinding
CRH09_RS11165	COG0477	Major facilitator Superfamily
CRH09_RS11175	COG0433	COG0433 Predicted ATPase
CRH09_RS11185	COG1957	nucleoside hydrolase
CRH09_RS11220	COG1309	transcriptional regulator
CRH09_RS11300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRH09_RS11310	COG1309	transcriptional regulator
CRH09_RS11315	COG3631	Ketosteroid isomerase-related protein
CRH09_RS11325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS11330	COG0542	response to heat
CRH09_RS11335	COG0693	protein deglycase activity
CRH09_RS11350	COG3201	nicotinamide mononucleotide transporter
CRH09_RS11355	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH09_RS11360	COG0022	dehydrogenase e1 component
CRH09_RS11365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CRH09_RS11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRH09_RS11390	COG3835	regulator
CRH09_RS11410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRH09_RS11415	COG2252	PERMEase
CRH09_RS11425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS11430	COG1024	Enoyl-CoA hydratase
CRH09_RS11440	COG0596	Alpha beta hydrolase
CRH09_RS11555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS11560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS11565	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS11575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRH09_RS11580	COG0596	Alpha beta hydrolase
CRH09_RS11605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS11635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS11650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CRH09_RS11705	COG1857	crispr-associated protein
CRH09_RS11720	COG1518	maintenance of DNA repeat elements
CRH09_RS11810	COG2124	cytochrome p450
CRH09_RS11835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS11845	COG1116	anion transmembrane transporter activity
CRH09_RS11865	COG3251	PFAM MbtH domain protein
CRH09_RS11885	COG1132	(ABC) transporter
CRH09_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS11955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS11955	COG4221	oxidoreductase activity
CRH09_RS11955	COG3321	synthase
CRH09_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS11960	COG3903	Transcriptional regulator
CRH09_RS11960	COG3629	intracellular signal transduction
CRH09_RS11965	COG0667	Aldo Keto reductase
CRH09_RS11980	COG0495	leucyl-tRNA aminoacylation
CRH09_RS11990	COG2124	cytochrome p450
CRH09_RS12040	COG1595	DNA-templated transcription, initiation
CRH09_RS12045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CRH09_RS12150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CRH09_RS12165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CRH09_RS12175	COG1846	Transcriptional regulator
CRH09_RS12210	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS12220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH09_RS12225	COG2936	dipeptidyl-peptidase activity
CRH09_RS12245	COG2365	Tyrosine phosphatase family
CRH09_RS12255	COG0174	glutamine synthetase
CRH09_RS12280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CRH09_RS12285	COG0321	lipoyl(octanoyl) transferase activity
CRH09_RS12310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRH09_RS12315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CRH09_RS12320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS12325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS12330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRH09_RS12360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CRH09_RS12365	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CRH09_RS12380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CRH09_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS12450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRH09_RS12455	COG1845	cytochrome c oxidase, subunit III
CRH09_RS12515	COG0003	Pfam Anion-transporting ATPase
CRH09_RS12525	COG1940	carbohydrate kinase activity
CRH09_RS12560	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CRH09_RS12580	COG0142	geranyltranstransferase activity
CRH09_RS12630	COG2001	Belongs to the MraZ family
CRH09_RS12635	COG0275	rRNA processing
CRH09_RS12645	COG0768	penicillin binding
CRH09_RS12660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRH09_RS12665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRH09_RS12675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRH09_RS12680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CRH09_RS12685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CRH09_RS12690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRH09_RS12705	COG1799	cell septum assembly
CRH09_RS12715	COG3599	regulation of cell shape
CRH09_RS12725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CRH09_RS12740	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS12745	COG0506	proline dehydrogenase activity
CRH09_RS12750	COG0477	Major facilitator Superfamily
CRH09_RS12770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRH09_RS12800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRH09_RS12820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRH09_RS12870	COG3290	protein histidine kinase activity
CRH09_RS12875	COG4565	transcriptional regulatory protein
CRH09_RS12880	COG2226	methyltransferase
CRH09_RS12890	COG2226	methyltransferase
CRH09_RS12910	COG4977	sequence-specific DNA binding
CRH09_RS12920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS12945	COG1609	Transcriptional regulator
CRH09_RS12980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CRH09_RS13015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRH09_RS13025	COG0156	8-amino-7-oxononanoate synthase activity
CRH09_RS13030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRH09_RS13050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRH09_RS13055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH09_RS13065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRH09_RS13165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRH09_RS13170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH09_RS13175	COG0131	Imidazoleglycerol-phosphate dehydratase
CRH09_RS13180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CRH09_RS13185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRH09_RS13190	COG0483	inositol monophosphate 1-phosphatase activity
CRH09_RS13195	COG0107	imidazoleglycerol-phosphate synthase activity
CRH09_RS13200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRH09_RS13225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRH09_RS13245	COG0159	tryptophan synthase activity
CRH09_RS13250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CRH09_RS13260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS13265	COG0765	amino acid transport
CRH09_RS13275	COG1946	Acyl-CoA thioesterase
CRH09_RS13285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRH09_RS13325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS13355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CRH09_RS13365	COG0473	3-isopropylmalate dehydrogenase activity
CRH09_RS13370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS13385	COG0583	DNA-binding transcription factor activity
CRH09_RS13405	COG2226	methyltransferase
CRH09_RS13410	COG0539	negative regulation of cytoplasmic translation
CRH09_RS13425	COG0237	dephospho-CoA kinase activity
CRH09_RS13425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CRH09_RS13480	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS13515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRH09_RS13520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CRH09_RS13530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRH09_RS13535	COG0072	phenylalanine-tRNA ligase activity
CRH09_RS13535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH09_RS13580	COG1414	Transcriptional regulator
CRH09_RS13595	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CRH09_RS13600	COG0800	Aldolase
CRH09_RS13605	COG2610	gluconate transmembrane transporter activity
CRH09_RS13615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CRH09_RS13620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CRH09_RS13625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRH09_RS13630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRH09_RS13640	COG1438	arginine binding
CRH09_RS13675	COG3344	reverse transcriptase
CRH09_RS13685	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRH09_RS13695	COG2186	Transcriptional regulator
CRH09_RS13705	COG3254	rhamnose metabolic process
CRH09_RS13710	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS13715	COG1129	ABC transporter
CRH09_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
CRH09_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS13740	COG3979	chitinase
CRH09_RS13745	COG0137	argininosuccinate synthase activity
CRH09_RS13755	COG0165	Argininosuccinate lyase
CRH09_RS13780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRH09_RS13790	COG1953	Uracil, thiamine, allantoin
CRH09_RS13795	COG1959	2 iron, 2 sulfur cluster binding
CRH09_RS13800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CRH09_RS13805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRH09_RS13810	COG3170	Tfp pilus assembly protein FimV
CRH09_RS13815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS13835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRH09_RS13840	COG0463	Glycosyl transferase, family 2
CRH09_RS13855	COG2835	tetraacyldisaccharide 4'-kinase activity
CRH09_RS13855	COG1663	tetraacyldisaccharide 4'-kinase activity
CRH09_RS13860	COG1309	transcriptional regulator
CRH09_RS13865	COG0842	Transport permease protein
CRH09_RS13880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRH09_RS13885	COG2094	Belongs to the DNA glycosylase MPG family
CRH09_RS13895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CRH09_RS13920	COG0647	UMP catabolic process
CRH09_RS13940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CRH09_RS13965	COG0504	CTP synthase activity
CRH09_RS13970	COG0494	nUDIX hydrolase
CRH09_RS13990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CRH09_RS13995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CRH09_RS14000	COG1187	pseudouridine synthase activity
CRH09_RS14005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CRH09_RS14010	COG1160	GTP binding
CRH09_RS14020	COG2957	Belongs to the agmatine deiminase family
CRH09_RS14030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CRH09_RS14035	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS14045	COG1228	amidohydrolase
CRH09_RS14050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CRH09_RS14055	COG2130	NADP-dependent
CRH09_RS14110	COG2175	clavaminate synthase activity
CRH09_RS14115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH09_RS14120	COG0142	geranyltranstransferase activity
CRH09_RS14135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS14170	COG3903	Transcriptional regulator
CRH09_RS14170	COG3629	intracellular signal transduction
CRH09_RS14190	COG0642	Histidine kinase
CRH09_RS14195	COG4681	YaeQ
CRH09_RS14205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS14210	COG0697	spore germination
CRH09_RS14215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CRH09_RS14220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRH09_RS14225	COG2971	BadF BadG BcrA BcrD
CRH09_RS14230	COG2814	Major facilitator Superfamily
CRH09_RS14235	COG2188	Transcriptional regulator
CRH09_RS14245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS14275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS14280	COG1846	Transcriptional regulator
CRH09_RS14350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS14360	COG1501	Belongs to the glycosyl hydrolase 31 family
CRH09_RS14365	COG0135	phosphoribosylanthranilate isomerase activity
CRH09_RS14410	COG0393	Putative heavy-metal-binding
CRH09_RS14415	COG0393	Putative heavy-metal-binding
CRH09_RS14465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS14470	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS14480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS14555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRH09_RS14630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRH09_RS14710	COG0745	RESPONSE REGULATOR receiver
CRH09_RS14715	COG2205	protein histidine kinase activity
CRH09_RS14735	COG1349	DNA-binding transcription factor activity
CRH09_RS14740	COG0149	triose-phosphate isomerase activity
CRH09_RS14745	COG2376	Dihydroxyacetone kinase
CRH09_RS14750	COG0698	ribose 5-phosphate isomerase
CRH09_RS14805	COG4585	Histidine kinase
CRH09_RS14810	COG2197	response regulator
CRH09_RS14815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS14820	COG1510	regulation of RNA biosynthetic process
CRH09_RS14830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS14880	COG0477	Major facilitator Superfamily
CRH09_RS14895	COG0631	protein serine/threonine phosphatase activity
CRH09_RS14900	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CRH09_RS14900	COG2066	Belongs to the glutaminase family
CRH09_RS14910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS14940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS14980	COG1132	(ABC) transporter
CRH09_RS15010	COG2070	2-Nitropropane dioxygenase
CRH09_RS15030	COG0640	Transcriptional regulator
CRH09_RS15045	COG1278	Cold shock
CRH09_RS15080	COG0477	Major facilitator Superfamily
CRH09_RS15135	COG3707	response regulator
CRH09_RS15170	COG3485	protocatechuate 3,4-dioxygenase
CRH09_RS15185	COG2130	NADP-dependent
CRH09_RS15195	COG1846	Transcriptional regulator
CRH09_RS15210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS15215	COG0142	geranyltranstransferase activity
CRH09_RS15270	COG2267	carboxylic ester hydrolase activity
CRH09_RS15285	COG4977	sequence-specific DNA binding
CRH09_RS15315	COG0588	phosphoglycerate mutase activity
CRH09_RS15645	COG1959	2 iron, 2 sulfur cluster binding
CRH09_RS15725	COG0477	Major facilitator Superfamily
CRH09_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS15760	COG2271	Major facilitator Superfamily
CRH09_RS15780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRH09_RS15785	COG0300	oxidoreductase activity
CRH09_RS15825	COG2124	cytochrome p450
CRH09_RS15840	COG1024	Enoyl-CoA hydratase
CRH09_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS15900	COG0739	heme binding
CRH09_RS16015	COG1309	transcriptional regulator
CRH09_RS16060	COG3511	phospholipase C
CRH09_RS16065	COG0252	asparaginase activity
CRH09_RS16075	COG0546	phosphoglycolate phosphatase activity
CRH09_RS16120	COG3265	gluconokinase activity
CRH09_RS16130	COG0004	ammonium transporteR
CRH09_RS16135	COG1846	Transcriptional regulator
CRH09_RS16145	COG1113	amino acid transport
CRH09_RS16170	COG1846	Transcriptional regulator
CRH09_RS16180	COG3835	regulator
CRH09_RS16260	COG3835	regulator
CRH09_RS16270	COG0702	epimerase
CRH09_RS16295	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS16330	COG2267	carboxylic ester hydrolase activity
CRH09_RS16340	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRH09_RS16345	COG0737	Belongs to the 5'-nucleotidase family
CRH09_RS16370	COG5398	heme oxygenase
CRH09_RS16395	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS16400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRH09_RS16475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRH09_RS16480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRH09_RS16495	COG2124	cytochrome p450
CRH09_RS16525	COG0477	Major facilitator Superfamily
CRH09_RS16550	COG0509	glycine decarboxylation via glycine cleavage system
CRH09_RS16555	COG1716	ATPase activity
CRH09_RS16575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRH09_RS16575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CRH09_RS16630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CRH09_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS16640	COG1309	transcriptional regulator
CRH09_RS16645	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS16660	COG2124	cytochrome p450
CRH09_RS16685	COG1253	flavin adenine dinucleotide binding
CRH09_RS16690	COG1253	flavin adenine dinucleotide binding
CRH09_RS16705	COG0513	Belongs to the DEAD box helicase family
CRH09_RS16725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH09_RS16730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH09_RS16745	COG0831	urea catabolic process
CRH09_RS16750	COG0832	Belongs to the urease beta subunit family
CRH09_RS16755	COG0804	urea catabolic process
CRH09_RS16760	COG4122	O-methyltransferase activity
CRH09_RS16770	COG0477	Major facilitator Superfamily
CRH09_RS16780	COG4221	oxidoreductase activity
CRH09_RS16790	COG0830	nickel cation binding
CRH09_RS16795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CRH09_RS16800	COG0829	nickel cation binding
CRH09_RS16810	COG2161	toxin-antitoxin pair type II binding
CRH09_RS16815	COG4115	mRNA cleavage
CRH09_RS16830	COG1252	NADH dehydrogenase
CRH09_RS16860	COG1074	ATP-dependent DNA helicase activity
CRH09_RS16880	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS16890	COG2890	protein-(glutamine-N5) methyltransferase activity
CRH09_RS16900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRH09_RS16905	COG1376	ErfK ybiS ycfS ynhG family protein
CRH09_RS16920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS16950	COG2172	sigma factor antagonist activity
CRH09_RS16955	COG1366	Belongs to the anti-sigma-factor antagonist family
CRH09_RS16960	COG1366	Belongs to the anti-sigma-factor antagonist family
CRH09_RS17055	COG0646	methionine synthase
CRH09_RS17055	COG1410	methionine synthase
CRH09_RS17085	COG0140	phosphoribosyl-ATP diphosphatase activity
CRH09_RS17090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CRH09_RS17110	COG1222	aaa ATPase
CRH09_RS17140	COG1309	transcriptional regulator
CRH09_RS17150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRH09_RS17165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRH09_RS17175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRH09_RS17190	COG2188	Transcriptional regulator
CRH09_RS17195	COG2814	Major facilitator Superfamily
CRH09_RS17200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CRH09_RS17210	COG1984	allophanate hydrolase subunit 2
CRH09_RS17255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CRH09_RS17255	COG2508	Transcriptional regulator
CRH09_RS17265	COG0174	glutamine synthetase
CRH09_RS17285	COG2072	flavoprotein involved in K transport
CRH09_RS17300	COG2814	Major facilitator Superfamily
CRH09_RS17320	COG0701	Predicted permease
CRH09_RS17335	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRH09_RS17340	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRH09_RS17345	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CRH09_RS17360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CRH09_RS17365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRH09_RS17440	COG1834	amidinotransferase
CRH09_RS17525	COG1309	transcriptional regulator
CRH09_RS17540	COG2197	response regulator
CRH09_RS17555	COG2140	Oxalate decarboxylase
CRH09_RS17570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS17585	COG0321	lipoyl(octanoyl) transferase activity
CRH09_RS17610	COG0739	heme binding
CRH09_RS17615	COG0640	Transcriptional regulator
CRH09_RS17665	COG1953	Uracil, thiamine, allantoin
CRH09_RS17675	COG2319	Wd-40 repeat
CRH09_RS17705	COG2223	nitrite transmembrane transporter activity
CRH09_RS17755	COG4608	Belongs to the ABC transporter superfamily
CRH09_RS17770	COG0601	transmembrane transport
CRH09_RS17780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS17785	COG1595	DNA-templated transcription, initiation
CRH09_RS17800	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS17805	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CRH09_RS17820	COG0517	IMP dehydrogenase activity
CRH09_RS17820	COG4175	Glycine betaine
CRH09_RS17825	COG2146	nitrite reductase [NAD(P)H] activity
CRH09_RS17835	COG4638	Rieske (2fe-2S)
CRH09_RS17855	COG0509	glycine decarboxylation via glycine cleavage system
CRH09_RS17880	COG1802	Transcriptional regulator
CRH09_RS17895	COG3629	intracellular signal transduction
CRH09_RS17895	COG3903	Transcriptional regulator
CRH09_RS17915	COG0784	Response regulator, receiver
CRH09_RS17915	COG2205	protein histidine kinase activity
CRH09_RS17915	COG5002	protein histidine kinase activity
CRH09_RS17925	COG2207	Transcriptional regulator
CRH09_RS17955	COG0667	Aldo Keto reductase
CRH09_RS17965	COG2814	Major facilitator Superfamily
CRH09_RS17970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS17985	COG0583	DNA-binding transcription factor activity
CRH09_RS17990	COG1850	ribulose-bisphosphate carboxylase activity
CRH09_RS17995	COG4451	ribulose bisphosphate carboxylase, small
CRH09_RS18000	COG0464	growth
CRH09_RS18005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CRH09_RS18010	COG3954	Phosphoribulokinase
CRH09_RS18030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CRH09_RS18035	COG1309	transcriptional regulator
CRH09_RS18075	COG2318	DinB family
CRH09_RS18080	COG0789	Transcriptional regulator
CRH09_RS18085	COG2070	2-Nitropropane dioxygenase
CRH09_RS18105	COG2318	DinB family
CRH09_RS18125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRH09_RS18125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRH09_RS18155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CRH09_RS18155	COG0235	Class ii aldolase
CRH09_RS18160	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CRH09_RS18165	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CRH09_RS18185	COG5000	phosphorelay sensor kinase activity
CRH09_RS18220	COG1073	alpha beta
CRH09_RS18230	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS18240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS18255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRH09_RS18320	COG1309	transcriptional regulator
CRH09_RS18330	COG2197	response regulator
CRH09_RS18340	COG3963	phosphatidate phosphatase activity
CRH09_RS18355	COG0477	Major facilitator Superfamily
CRH09_RS18375	COG0583	DNA-binding transcription factor activity
CRH09_RS18380	COG0529	Catalyzes the synthesis of activated sulfate
CRH09_RS18395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CRH09_RS18435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS18440	COG2175	clavaminate synthase activity
CRH09_RS18460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS18465	COG0596	Alpha beta hydrolase
CRH09_RS18465	COG2945	thiolester hydrolase activity
CRH09_RS18470	COG1733	regulation of RNA biosynthetic process
CRH09_RS18475	COG0018	arginyl-trna synthetase
CRH09_RS18480	COG3226	Transcriptional regulator
CRH09_RS18515	COG2259	Doxx family
CRH09_RS18535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CRH09_RS18540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CRH09_RS18545	COG0183	Belongs to the thiolase family
CRH09_RS18550	COG3485	protocatechuate 3,4-dioxygenase
CRH09_RS18555	COG3485	protocatechuate 3,4-dioxygenase
CRH09_RS18565	COG2267	carboxylic ester hydrolase activity
CRH09_RS18570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRH09_RS18615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRH09_RS18620	COG0028	Belongs to the TPP enzyme family
CRH09_RS18640	COG2814	Major facilitator Superfamily
CRH09_RS18645	COG1522	sequence-specific DNA binding
CRH09_RS18665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS18675	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS18710	COG1733	regulation of RNA biosynthetic process
CRH09_RS18715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRH09_RS18720	COG0372	Belongs to the citrate synthase family
CRH09_RS18740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRH09_RS18755	COG0640	Transcriptional regulator
CRH09_RS18780	COG0601	transmembrane transport
CRH09_RS18785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS18795	COG4608	Belongs to the ABC transporter superfamily
CRH09_RS18830	COG1309	transcriptional regulator
CRH09_RS18855	COG1309	transcriptional regulator
CRH09_RS18860	COG2837	iron assimilation
CRH09_RS18865	COG2847	Copper chaperone PCu(A)C
CRH09_RS18880	COG0745	RESPONSE REGULATOR receiver
CRH09_RS18885	COG2205	protein histidine kinase activity
CRH09_RS18905	COG2267	carboxylic ester hydrolase activity
CRH09_RS18925	COG0346	lactoylglutathione lyase activity
CRH09_RS18950	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CRH09_RS18970	COG3191	aminopeptidase activity
CRH09_RS19020	COG0477	Major facilitator Superfamily
CRH09_RS19025	COG0477	Major facilitator Superfamily
CRH09_RS19065	COG2070	2-Nitropropane dioxygenase
CRH09_RS19100	COG1024	Enoyl-CoA hydratase
CRH09_RS19105	COG1309	transcriptional regulator
CRH09_RS19110	COG0215	cysteine-tRNA ligase activity
CRH09_RS19130	COG0667	Aldo Keto reductase
CRH09_RS19135	COG4558	Periplasmic binding protein
CRH09_RS19140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH09_RS19145	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CRH09_RS19150	COG2319	Wd-40 repeat
CRH09_RS19155	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS19185	COG0167	dihydroorotate dehydrogenase activity
CRH09_RS19215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH09_RS19220	COG1733	regulation of RNA biosynthetic process
CRH09_RS19225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRH09_RS19230	COG4585	Histidine kinase
CRH09_RS19235	COG2197	response regulator
CRH09_RS19265	COG1309	transcriptional regulator
CRH09_RS19280	COG4552	Acetyltransferase involved in intracellular survival and related
CRH09_RS19300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRH09_RS19320	COG2124	cytochrome p450
CRH09_RS19360	COG2608	mercury ion transmembrane transporter activity
CRH09_RS19375	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS19385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRH09_RS19400	COG0583	DNA-binding transcription factor activity
CRH09_RS19410	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS19420	COG4941	Belongs to the sigma-70 factor family
CRH09_RS19425	COG3795	YCII-related domain
CRH09_RS19435	COG0352	thiamine-phosphate diphosphorylase activity
CRH09_RS19440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRH09_RS19445	COG1454	alcohol dehydrogenase
CRH09_RS19450	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CRH09_RS19450	COG0028	Belongs to the TPP enzyme family
CRH09_RS19465	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS19480	COG3629	intracellular signal transduction
CRH09_RS19480	COG3903	Transcriptional regulator
CRH09_RS19485	COG4585	Histidine kinase
CRH09_RS19490	COG2197	response regulator
CRH09_RS19495	COG1063	alcohol dehydrogenase
CRH09_RS19500	COG2390	Transcriptional regulator
CRH09_RS19505	COG1070	Carbohydrate kinase
CRH09_RS19535	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS19615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS19620	COG1595	DNA-templated transcription, initiation
CRH09_RS19635	COG0517	IMP dehydrogenase activity
CRH09_RS19650	COG0583	DNA-binding transcription factor activity
CRH09_RS19660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRH09_RS19665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRH09_RS19670	COG0649	NAD binding
CRH09_RS19680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CRH09_RS19685	COG1034	ATP synthesis coupled electron transport
CRH09_RS19690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRH09_RS19690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRH09_RS19700	COG0713	ATP synthesis coupled electron transport
CRH09_RS19805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS19810	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS19825	COG0596	Alpha beta hydrolase
CRH09_RS19830	COG0596	Alpha beta hydrolase
CRH09_RS19885	COG2318	DinB family
CRH09_RS19930	COG0657	acetylesterase activity
CRH09_RS19935	COG2272	Belongs to the type-B carboxylesterase lipase family
CRH09_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS19975	COG1959	2 iron, 2 sulfur cluster binding
CRH09_RS19980	COG0477	Major facilitator Superfamily
CRH09_RS19990	COG0789	Transcriptional regulator
CRH09_RS20010	COG2197	response regulator
CRH09_RS20075	COG2814	Major facilitator Superfamily
CRH09_RS20085	COG0402	S-adenosylhomocysteine deaminase activity
CRH09_RS20100	COG0596	Alpha beta hydrolase
CRH09_RS20120	COG0789	Transcriptional regulator
CRH09_RS20165	COG4585	Histidine kinase
CRH09_RS20170	COG2070	2-Nitropropane dioxygenase
CRH09_RS20175	COG1942	4-Oxalocrotonate Tautomerase
CRH09_RS20185	COG1309	transcriptional regulator
CRH09_RS20295	COG1234	tRNA 3'-trailer cleavage
CRH09_RS20315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS20320	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS20345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRH09_RS20350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRH09_RS20355	COG2192	nodulation
CRH09_RS20375	COG1335	isochorismatase
CRH09_RS20395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS20400	COG3876	Protein conserved in bacteria
CRH09_RS20405	COG0174	glutamine synthetase
CRH09_RS20410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRH09_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS20425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRH09_RS20430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRH09_RS20450	COG0531	amino acid
CRH09_RS20455	COG1233	COG1233 Phytoene dehydrogenase and related
CRH09_RS20460	COG0477	Major facilitator Superfamily
CRH09_RS20465	COG2070	2-Nitropropane dioxygenase
CRH09_RS20465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CRH09_RS20475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRH09_RS20545	COG1846	Transcriptional regulator
CRH09_RS20550	COG4166	transmembrane transport
CRH09_RS20600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CRH09_RS20605	COG3321	synthase
CRH09_RS20605	COG0604	alcohol dehydrogenase
CRH09_RS20615	COG0604	alcohol dehydrogenase
CRH09_RS20615	COG3321	synthase
CRH09_RS20635	COG1819	glycosyl
CRH09_RS20705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRH09_RS20715	COG2814	Major facilitator Superfamily
CRH09_RS20740	COG3485	protocatechuate 3,4-dioxygenase
CRH09_RS20745	COG0596	Alpha beta hydrolase
CRH09_RS20760	COG1285	pathogenesis
CRH09_RS20765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRH09_RS20765	COG1024	Enoyl-CoA hydratase
CRH09_RS20790	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CRH09_RS20810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS20850	COG1802	Transcriptional regulator
CRH09_RS20895	COG1902	pentaerythritol trinitrate reductase activity
CRH09_RS20900	COG1793	dna ligase
CRH09_RS20900	COG3285	dna ligase
CRH09_RS20910	COG2318	DinB family
CRH09_RS20915	COG0456	acetyltransferase
CRH09_RS20920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRH09_RS20925	COG1316	TRANSCRIPTIONal
CRH09_RS20930	COG1316	TRANSCRIPTIONal
CRH09_RS20980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRH09_RS20995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS21020	COG1285	pathogenesis
CRH09_RS21030	COG1116	anion transmembrane transporter activity
CRH09_RS21040	COG0477	Major facilitator Superfamily
CRH09_RS21045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CRH09_RS21065	COG0477	Major facilitator Superfamily
CRH09_RS21070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRH09_RS21080	COG1120	ATPase activity
CRH09_RS21085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRH09_RS21135	COG1733	regulation of RNA biosynthetic process
CRH09_RS21140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CRH09_RS21150	COG2364	Membrane
CRH09_RS21180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS21185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS21195	COG3706	GGDEF domain
CRH09_RS21210	COG2268	Band 7 protein
CRH09_RS21220	COG1793	dna ligase
CRH09_RS21230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CRH09_RS21240	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS21250	COG0596	Alpha beta hydrolase
CRH09_RS21265	COG4122	O-methyltransferase activity
CRH09_RS21270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CRH09_RS21320	COG3226	Transcriptional regulator
CRH09_RS21355	COG0745	RESPONSE REGULATOR receiver
CRH09_RS21360	COG2205	protein histidine kinase activity
CRH09_RS21380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS21405	COG0789	Transcriptional regulator
CRH09_RS21480	COG1388	LysM domain
CRH09_RS21500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRH09_RS21505	COG4521	taurine ABC transporter
CRH09_RS21510	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CRH09_RS21515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CRH09_RS21540	COG2378	regulation of single-species biofilm formation
CRH09_RS21595	COG2267	carboxylic ester hydrolase activity
CRH09_RS21605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CRH09_RS21610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRH09_RS21620	COG2304	oxidoreductase activity
CRH09_RS21630	COG0714	Associated with various cellular activities
CRH09_RS21635	COG3883	PFAM NLP P60 protein
CRH09_RS21635	COG0791	NLP P60 protein
CRH09_RS21645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CRH09_RS21650	COG1309	transcriptional regulator
CRH09_RS21690	COG0488	(ABC) transporter
CRH09_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS21745	COG1764	response to oxidative stress
CRH09_RS21750	COG1846	Transcriptional regulator
CRH09_RS21755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CRH09_RS21770	COG2072	flavoprotein involved in K transport
CRH09_RS21790	COG0277	FAD linked oxidase domain protein
CRH09_RS21820	COG2814	Major facilitator Superfamily
CRH09_RS21835	COG1132	(ABC) transporter
CRH09_RS21850	COG4221	oxidoreductase activity
CRH09_RS21880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRH09_RS21895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS21905	COG2030	dehydratase
CRH09_RS21910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CRH09_RS21925	COG0512	Glutamine amidotransferase of anthranilate synthase
CRH09_RS21925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRH09_RS21975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRH09_RS21980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRH09_RS21985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CRH09_RS22005	COG1464	Belongs to the NlpA lipoprotein family
CRH09_RS22015	COG2011	ABC-type metal ion transport system permease component
CRH09_RS22020	COG2151	metal-sulfur cluster biosynthetic enzyme
CRH09_RS22035	COG0396	ATPase activity
CRH09_RS22060	COG1131	(ABC) transporter
CRH09_RS22105	COG1309	transcriptional regulator
CRH09_RS22120	COG0109	protoheme IX farnesyltransferase activity
CRH09_RS22130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CRH09_RS22155	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CRH09_RS22155	COG0778	Nitroreductase
CRH09_RS22160	COG2267	carboxylic ester hydrolase activity
CRH09_RS22165	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS22180	COG0583	DNA-binding transcription factor activity
CRH09_RS22195	COG0022	dehydrogenase e1 component
CRH09_RS22210	COG0149	triose-phosphate isomerase activity
CRH09_RS22215	COG0126	phosphoglycerate kinase activity
CRH09_RS22220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRH09_RS22230	COG1481	regulation of sporulation
CRH09_RS22240	COG1660	Displays ATPase and GTPase activities
CRH09_RS22245	COG0322	excinuclease ABC activity
CRH09_RS22250	COG0583	DNA-binding transcription factor activity
CRH09_RS22270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS22275	COG3214	Protein conserved in bacteria
CRH09_RS22300	COG1119	ATPase activity
CRH09_RS22310	COG0405	Gamma-glutamyltransferase
CRH09_RS22325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRH09_RS22330	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRH09_RS22330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRH09_RS22365	COG4948	Mandelate Racemase Muconate Lactonizing
CRH09_RS22375	COG4948	Mandelate Racemase Muconate Lactonizing
CRH09_RS22380	COG1802	Transcriptional regulator
CRH09_RS22400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRH09_RS22405	COG0242	peptide deformylase activity
CRH09_RS22415	COG1695	Transcriptional regulator
CRH09_RS22430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRH09_RS22435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRH09_RS22445	COG1758	RNA polymerase activity
CRH09_RS22450	COG0194	GDP metabolic process
CRH09_RS22460	COG0284	orotidine-5'-phosphate decarboxylase activity
CRH09_RS22475	COG0505	Belongs to the CarA family
CRH09_RS22490	COG0540	Belongs to the ATCase OTCase family
CRH09_RS22495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CRH09_RS22510	COG0477	Major facilitator Superfamily
CRH09_RS22545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CRH09_RS22550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRH09_RS22565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRH09_RS22575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CRH09_RS22585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRH09_RS22595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CRH09_RS22600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRH09_RS22620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CRH09_RS22635	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRH09_RS22640	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRH09_RS22640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRH09_RS22650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRH09_RS22675	COG0039	L-malate dehydrogenase activity
CRH09_RS22685	COG0124	histidyl-tRNA synthetase
CRH09_RS22690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRH09_RS22715	COG0741	lytic transglycosylase activity
CRH09_RS22715	COG0739	heme binding
CRH09_RS22715	COG1196	nuclear chromosome segregation
CRH09_RS22780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRH09_RS22795	COG0477	Major facilitator Superfamily
CRH09_RS22795	COG2814	Major facilitator Superfamily
CRH09_RS22825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRH09_RS22830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRH09_RS22845	COG0277	FAD linked oxidase domain protein
CRH09_RS22865	COG1742	UPF0060 membrane protein
CRH09_RS22870	COG0488	(ABC) transporter
CRH09_RS22885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRH09_RS22890	COG0747	negative chemotaxis
CRH09_RS22895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRH09_RS22900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRH09_RS22905	COG1862	Preprotein translocase
CRH09_RS22920	COG3599	regulation of cell shape
CRH09_RS22930	COG2255	four-way junction helicase activity
CRH09_RS22935	COG0632	four-way junction helicase activity
CRH09_RS22940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CRH09_RS22970	COG0395	ABC-type sugar transport system, permease component
CRH09_RS22975	COG3842	ATPase activity
CRH09_RS22995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRH09_RS23030	COG3321	synthase
CRH09_RS23030	COG0604	alcohol dehydrogenase
CRH09_RS23040	COG0217	transcriptional regulatory protein
CRH09_RS23045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CRH09_RS23050	COG0531	amino acid
CRH09_RS23065	COG1946	Acyl-CoA thioesterase
CRH09_RS23085	COG0017	Asparaginyl-tRNA synthetase
CRH09_RS23115	COG1765	OsmC-like protein
CRH09_RS23120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CRH09_RS23165	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS23170	COG1560	Kdo2-lipid A biosynthetic process
CRH09_RS23215	COG1070	Carbohydrate kinase
CRH09_RS23220	COG1063	alcohol dehydrogenase
CRH09_RS23230	COG2814	Major facilitator Superfamily
CRH09_RS23265	COG1660	Displays ATPase and GTPase activities
CRH09_RS23275	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS23280	COG2226	methyltransferase
CRH09_RS23315	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS23320	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS23325	COG1309	transcriptional regulator
CRH09_RS23350	COG3226	Transcriptional regulator
CRH09_RS23365	COG0483	inositol monophosphate 1-phosphatase activity
CRH09_RS23375	COG1309	transcriptional regulator
CRH09_RS23415	COG0076	glutamate decarboxylase activity
CRH09_RS23450	COG0789	Transcriptional regulator
CRH09_RS23455	COG0748	coenzyme F420 binding
CRH09_RS23460	COG2367	Beta-lactamase
CRH09_RS23465	COG0659	secondary active sulfate transmembrane transporter activity
CRH09_RS23490	COG1940	carbohydrate kinase activity
CRH09_RS23490	COG1846	Transcriptional regulator
CRH09_RS23500	COG1175	transmembrane transport
CRH09_RS23505	COG0395	ABC-type sugar transport system, permease component
CRH09_RS23510	COG1486	melibiose metabolic process
CRH09_RS23530	COG0745	RESPONSE REGULATOR receiver
CRH09_RS23535	COG2205	protein histidine kinase activity
CRH09_RS23555	COG1620	l-lactate permease
CRH09_RS23560	COG0247	lactate metabolic process
CRH09_RS23560	COG0277	FAD linked oxidase domain protein
CRH09_RS23585	COG1175	transmembrane transport
CRH09_RS23595	COG3842	ATPase activity
CRH09_RS23600	COG2084	Dehydrogenase
CRH09_RS23610	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS23615	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS23620	COG1129	ABC transporter
CRH09_RS23625	COG1879	ABC-type sugar transport system periplasmic component
CRH09_RS23635	COG2319	Wd-40 repeat
CRH09_RS23670	COG0596	Alpha beta hydrolase
CRH09_RS23685	COG3469	chitinase activity
CRH09_RS23685	COG3325	Belongs to the glycosyl hydrolase 18 family
CRH09_RS23735	COG4221	oxidoreductase activity
CRH09_RS23745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS23750	COG0477	Major facilitator Superfamily
CRH09_RS23760	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS23775	COG0142	geranyltranstransferase activity
CRH09_RS23790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS23820	COG0789	Transcriptional regulator
CRH09_RS23840	COG4941	Belongs to the sigma-70 factor family
CRH09_RS23855	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS23875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CRH09_RS23880	COG3835	regulator
CRH09_RS23885	COG1562	ergosterol biosynthetic process
CRH09_RS23895	COG1233	COG1233 Phytoene dehydrogenase and related
CRH09_RS23905	COG1657	PFAM Prenyltransferase squalene oxidase
CRH09_RS23920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRH09_RS23930	COG0642	Histidine kinase
CRH09_RS23945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CRH09_RS23950	COG0745	RESPONSE REGULATOR receiver
CRH09_RS23965	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS23995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRH09_RS24015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS24025	COG1132	(ABC) transporter
CRH09_RS24060	COG2124	cytochrome p450
CRH09_RS24065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS24135	COG0477	Major facilitator Superfamily
CRH09_RS24185	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS24200	COG0714	Associated with various cellular activities
CRH09_RS24265	COG0028	Belongs to the TPP enzyme family
CRH09_RS24305	COG0640	Transcriptional regulator
CRH09_RS24310	COG0477	Major facilitator Superfamily
CRH09_RS24350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS24355	COG2365	Tyrosine phosphatase family
CRH09_RS24380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRH09_RS24395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CRH09_RS24415	COG2205	protein histidine kinase activity
CRH09_RS24430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRH09_RS24440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRH09_RS24445	COG0531	amino acid
CRH09_RS24450	COG0569	domain protein
CRH09_RS24490	COG0756	dUTP diphosphatase activity
CRH09_RS24540	COG4303	Ethanolamine ammonia lyase large subunit
CRH09_RS24550	COG0475	glutathione-regulated potassium exporter activity
CRH09_RS24570	COG1309	transcriptional regulator
CRH09_RS24575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CRH09_RS24595	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS24600	COG1309	transcriptional regulator
CRH09_RS24635	COG4977	sequence-specific DNA binding
CRH09_RS24640	COG2890	protein-(glutamine-N5) methyltransferase activity
CRH09_RS24660	COG0640	Transcriptional regulator
CRH09_RS24670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CRH09_RS24705	COG0142	geranyltranstransferase activity
CRH09_RS24720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRH09_RS24730	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CRH09_RS24740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CRH09_RS24750	COG2124	cytochrome p450
CRH09_RS24760	COG0384	phenazine biosynthesis protein PhzF
CRH09_RS24765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CRH09_RS24770	COG0450	alkyl hydroperoxide reductase
CRH09_RS24795	COG0454	-acetyltransferase
CRH09_RS24810	COG1643	Atp-dependent helicase
CRH09_RS24815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CRH09_RS24830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CRH09_RS24845	COG1230	cation diffusion facilitator family transporter
CRH09_RS24860	COG1335	isochorismatase
CRH09_RS24875	COG5001	Diguanylate cyclase
CRH09_RS24890	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS24935	COG0402	S-adenosylhomocysteine deaminase activity
CRH09_RS24955	COG2205	protein histidine kinase activity
CRH09_RS24960	COG0745	RESPONSE REGULATOR receiver
CRH09_RS25020	COG1309	transcriptional regulator
CRH09_RS25025	COG0667	Aldo Keto reductase
CRH09_RS25045	COG0789	Transcriptional regulator
CRH09_RS25070	COG2318	DinB family
CRH09_RS25085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRH09_RS25155	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS25165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CRH09_RS25175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CRH09_RS25185	COG1196	nuclear chromosome segregation
CRH09_RS25195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRH09_RS25200	COG1126	abc transporter atp-binding protein
CRH09_RS25205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS25210	COG0765	amino acid transport
CRH09_RS25215	COG0765	amino acid transport
CRH09_RS25225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CRH09_RS25230	COG0525	valine-tRNA ligase activity
CRH09_RS25265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRH09_RS25280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CRH09_RS25315	COG0751	glycine-tRNA ligase activity
CRH09_RS25315	COG0752	glycyl-tRNA synthetase alpha subunit
CRH09_RS25325	COG1842	Phage shock protein A
CRH09_RS25330	COG1396	sequence-specific DNA binding
CRH09_RS25335	COG1546	Belongs to the CinA family
CRH09_RS25335	COG1058	Belongs to the CinA family
CRH09_RS25345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CRH09_RS25375	COG1674	ftsk spoiiie
CRH09_RS25380	COG3629	intracellular signal transduction
CRH09_RS25380	COG3903	Transcriptional regulator
CRH09_RS25415	COG4566	intracellular signal transduction
CRH09_RS25440	COG4266	Belongs to the allantoicase family
CRH09_RS25455	COG4977	sequence-specific DNA binding
CRH09_RS25465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRH09_RS25475	COG4221	oxidoreductase activity
CRH09_RS25485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS25515	COG1335	isochorismatase
CRH09_RS25600	COG0667	Aldo Keto reductase
CRH09_RS25730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CRH09_RS25735	COG3629	intracellular signal transduction
CRH09_RS25735	COG3903	Transcriptional regulator
CRH09_RS25800	COG1185	polyribonucleotide nucleotidyltransferase activity
CRH09_RS25805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CRH09_RS25825	COG0473	3-isopropylmalate dehydrogenase activity
CRH09_RS25835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS25860	COG1668	transmembrane transport
CRH09_RS25865	COG4152	abc transporter atp-binding protein
CRH09_RS25940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CRH09_RS25950	COG2080	2 iron, 2 sulfur cluster binding
CRH09_RS25955	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CRH09_RS25960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRH09_RS25975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CRH09_RS25985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CRH09_RS25990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CRH09_RS26000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRH09_RS26000	COG0481	GTPase activity
CRH09_RS26010	COG0195	Participates in both transcription termination and antitermination
CRH09_RS26015	COG0779	Required for maturation of 30S ribosomal subunits
CRH09_RS26025	COG0442	prolyl-tRNA aminoacylation
CRH09_RS26035	COG3022	response to hydroperoxide
CRH09_RS26045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS26085	COG2375	cellular response to nickel ion
CRH09_RS26085	COG1132	(ABC) transporter
CRH09_RS26105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS26155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CRH09_RS26155	COG1648	precorrin-2 dehydrogenase activity
CRH09_RS26220	COG0579	oxidoreductase
CRH09_RS26235	COG1492	cobalamin metabolic process
CRH09_RS26250	COG2188	Transcriptional regulator
CRH09_RS26260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRH09_RS26280	COG1177	transmembrane transport
CRH09_RS26295	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CRH09_RS26350	COG1073	alpha beta
CRH09_RS26355	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CRH09_RS26370	COG3629	intracellular signal transduction
CRH09_RS26370	COG3903	Transcriptional regulator
CRH09_RS26375	COG3903	Transcriptional regulator
CRH09_RS26375	COG3629	intracellular signal transduction
CRH09_RS26380	COG2226	methyltransferase
CRH09_RS26445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CRH09_RS26450	COG0745	RESPONSE REGULATOR receiver
CRH09_RS26455	COG2205	protein histidine kinase activity
CRH09_RS26575	COG3293	Transposase
CRH09_RS26585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CRH09_RS26610	COG3548	integral membrane protein
CRH09_RS26630	COG0142	geranyltranstransferase activity
CRH09_RS26635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CRH09_RS26650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS26655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS26660	COG0142	geranyltranstransferase activity
CRH09_RS26670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS26790	COG1819	glycosyl
CRH09_RS26805	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CRH09_RS26830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRH09_RS26835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS26840	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS26870	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS26890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS26895	COG0156	8-amino-7-oxononanoate synthase activity
CRH09_RS26900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRH09_RS26905	COG3629	intracellular signal transduction
CRH09_RS26925	COG2409	Drug exporters of the RND superfamily
CRH09_RS26960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CRH09_RS26965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRH09_RS26995	COG0596	Alpha beta hydrolase
CRH09_RS27050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CRH09_RS27090	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CRH09_RS27095	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CRH09_RS27115	COG1269	ATP hydrolysis coupled proton transport
CRH09_RS27150	COG2319	Wd-40 repeat
CRH09_RS27165	COG0640	Transcriptional regulator
CRH09_RS27240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CRH09_RS27245	COG0346	lactoylglutathione lyase activity
CRH09_RS27265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRH09_RS27300	COG2124	cytochrome p450
CRH09_RS27305	COG1132	(ABC) transporter
CRH09_RS27320	COG1609	Transcriptional regulator
CRH09_RS27345	COG0366	Alpha amylase catalytic
CRH09_RS27350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRH09_RS27355	COG2423	ornithine cyclodeaminase activity
CRH09_RS27360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRH09_RS27375	COG1509	lysine 2,3-aminomutase activity
CRH09_RS27405	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CRH09_RS27410	COG0589	response to stress
CRH09_RS27480	COG0745	RESPONSE REGULATOR receiver
CRH09_RS27485	COG2205	protein histidine kinase activity
CRH09_RS27495	COG2755	lipolytic protein G-D-S-L family
CRH09_RS27495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CRH09_RS27535	COG0194	GDP metabolic process
CRH09_RS27555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CRH09_RS27570	COG4555	ABC transporter
CRH09_RS27640	COG2226	methyltransferase
CRH09_RS27685	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CRH09_RS27700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CRH09_RS27725	COG1515	deoxyribonuclease V activity
CRH09_RS27740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRH09_RS27765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRH09_RS27775	COG0747	negative chemotaxis
CRH09_RS27780	COG0405	Gamma-glutamyltransferase
CRH09_RS27785	COG0583	DNA-binding transcription factor activity
CRH09_RS27815	COG1401	restriction endodeoxyribonuclease activity
CRH09_RS27820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CRH09_RS27825	COG5416	Lipopolysaccharide assembly protein A domain
CRH09_RS27840	COG0233	cytoplasmic translational termination
CRH09_RS27845	COG0528	UMP kinase activity
CRH09_RS27850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRH09_RS27855	COG0052	Belongs to the universal ribosomal protein uS2 family
CRH09_RS27890	COG4974	Belongs to the 'phage' integrase family
CRH09_RS27930	COG0792	nuclease activity
CRH09_RS27940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRH09_RS27950	COG0335	large ribosomal subunit rRNA binding
CRH09_RS27960	COG2183	response to ionizing radiation
CRH09_RS27965	COG0336	Belongs to the RNA methyltransferase TrmD family
CRH09_RS27970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRH09_RS27980	COG0228	four-way junction DNA binding
CRH09_RS27985	COG2226	methyltransferase
CRH09_RS28010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CRH09_RS28070	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS28075	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS28080	COG5285	phytanoyl-CoA dioxygenase
CRH09_RS28085	COG1917	Cupin 2, conserved barrel domain protein
CRH09_RS28090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS28095	COG0456	acetyltransferase
CRH09_RS28100	COG2205	protein histidine kinase activity
CRH09_RS28105	COG0745	RESPONSE REGULATOR receiver
CRH09_RS28110	COG1376	ErfK ybiS ycfS ynhG family protein
CRH09_RS28115	COG2311	Membrane
CRH09_RS28125	COG1396	sequence-specific DNA binding
CRH09_RS28130	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRH09_RS28135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRH09_RS28165	COG1254	Belongs to the acylphosphatase family
CRH09_RS28175	COG0754	glutathionylspermidine amidase activity
CRH09_RS28180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CRH09_RS28180	COG1796	DNA polymerase
CRH09_RS28185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CRH09_RS28190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRH09_RS28195	COG0571	ribonuclease III activity
CRH09_RS28200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRH09_RS28225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRH09_RS28230	COG0742	ribosomal rna small subunit methyltransferase
CRH09_RS28235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CRH09_RS28255	COG1396	sequence-specific DNA binding
CRH09_RS28255	COG3800	Transcriptional regulator
CRH09_RS28260	COG5006	permease, DMT superfamily
CRH09_RS28265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRH09_RS28270	COG1461	Dihydroxyacetone kinase
CRH09_RS28285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRH09_RS28300	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRH09_RS28305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CRH09_RS28310	COG1920	GTP binding
CRH09_RS28315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRH09_RS28330	COG0066	3-isopropylmalate dehydratase activity
CRH09_RS28335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRH09_RS28360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRH09_RS28365	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRH09_RS28370	COG2271	Major facilitator Superfamily
CRH09_RS28380	COG0473	3-isopropylmalate dehydrogenase activity
CRH09_RS28395	COG1278	Cold shock
CRH09_RS28400	COG1278	Cold shock
CRH09_RS28405	COG3962	Belongs to the TPP enzyme family
CRH09_RS28410	COG3718	enzyme involved in inositol metabolism
CRH09_RS28420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CRH09_RS28430	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS28445	COG1609	Transcriptional regulator
CRH09_RS28455	COG0673	inositol 2-dehydrogenase activity
CRH09_RS28475	COG0747	negative chemotaxis
CRH09_RS28495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CRH09_RS28500	COG0440	acetolactate synthase activity
CRH09_RS28515	COG0129	dihydroxy-acid dehydratase activity
CRH09_RS28520	COG2259	Doxx family
CRH09_RS28530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRH09_RS28545	COG1136	(ABC) transporter
CRH09_RS28555	COG4585	Histidine kinase
CRH09_RS28560	COG2197	response regulator
CRH09_RS28600	COG2197	response regulator
CRH09_RS28605	COG1968	undecaprenyl-diphosphatase activity
CRH09_RS28610	COG4585	Histidine kinase
CRH09_RS28625	COG0154	amidase activity
CRH09_RS28630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CRH09_RS28645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRH09_RS28660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS28670	COG0640	Transcriptional regulator
CRH09_RS28690	COG0482	sulfurtransferase activity
CRH09_RS28725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRH09_RS28735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CRH09_RS28745	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CRH09_RS28785	COG2205	protein histidine kinase activity
CRH09_RS28790	COG0745	RESPONSE REGULATOR receiver
CRH09_RS28795	COG0583	DNA-binding transcription factor activity
CRH09_RS28800	COG0446	pyridine nucleotide-disulphide oxidoreductase
CRH09_RS28810	COG0110	maltose O-acetyltransferase activity
CRH09_RS28825	COG2226	methyltransferase
CRH09_RS28840	COG1119	ATPase activity
CRH09_RS28855	COG3830	Belongs to the UPF0237 family
CRH09_RS28855	COG0560	Phosphoserine phosphatase
CRH09_RS28860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CRH09_RS28880	COG0592	DNA-directed DNA polymerase activity
CRH09_RS28910	COG0642	Histidine kinase
CRH09_RS28930	COG1780	Probably involved in ribonucleotide reductase function
CRH09_RS28950	COG1309	transcriptional regulator
CRH09_RS28955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRH09_RS28975	COG0315	cyclic pyranopterin monophosphate synthase activity
CRH09_RS28975	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRH09_RS28980	COG0314	molybdopterin synthase activity
CRH09_RS28990	COG2233	PERMEase
CRH09_RS29000	COG3835	regulator
CRH09_RS29020	COG0723	plastoquinol--plastocyanin reductase activity
CRH09_RS29040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CRH09_RS29050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS29055	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS29110	COG5002	protein histidine kinase activity
CRH09_RS29115	COG0745	RESPONSE REGULATOR receiver
CRH09_RS29145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS29150	COG0701	Predicted permease
CRH09_RS29160	COG0702	epimerase
CRH09_RS29250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRH09_RS29255	COG1737	Transcriptional regulator
CRH09_RS29260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CRH09_RS29265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CRH09_RS29300	COG2234	aminopeptidase activity
CRH09_RS29305	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS29330	COG2124	cytochrome p450
CRH09_RS29370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRH09_RS29385	COG2124	cytochrome p450
CRH09_RS29390	COG2723	6-phospho-beta-galactosidase activity
CRH09_RS29410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CRH09_RS29430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CRH09_RS29435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS29500	COG1278	Cold shock
CRH09_RS29580	COG3511	phospholipase C
CRH09_RS29585	COG2936	dipeptidyl-peptidase activity
CRH09_RS29600	COG1902	pentaerythritol trinitrate reductase activity
CRH09_RS29605	COG1476	TRANSCRIPTIONal
CRH09_RS29650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS29655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS29710	COG1309	transcriptional regulator
CRH09_RS29725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS29745	COG1609	Transcriptional regulator
CRH09_RS29750	COG1879	ABC-type sugar transport system periplasmic component
CRH09_RS29755	COG1172	Belongs to the binding-protein-dependent transport system permease family
CRH09_RS29760	COG1129	ABC transporter
CRH09_RS29770	COG3485	protocatechuate 3,4-dioxygenase
CRH09_RS29780	COG0583	DNA-binding transcription factor activity
CRH09_RS29785	COG0688	phosphatidylethanolamine metabolic process
CRH09_RS29795	COG1132	(ABC) transporter
CRH09_RS29805	COG2957	Belongs to the agmatine deiminase family
CRH09_RS29820	COG1403	HNH endonuclease
CRH09_RS29875	COG1946	Acyl-CoA thioesterase
CRH09_RS29885	COG1278	Cold shock
CRH09_RS29920	COG0587	DNA-directed DNA polymerase activity
CRH09_RS29925	COG2211	Major facilitator Superfamily
CRH09_RS29930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRH09_RS29940	COG4974	Belongs to the 'phage' integrase family
CRH09_RS29955	COG2201	protein-glutamate methylesterase activity
CRH09_RS29965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRH09_RS30000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS30005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS30010	COG2030	dehydratase
CRH09_RS30015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS30030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS30040	COG3903	Transcriptional regulator
CRH09_RS30040	COG3629	intracellular signal transduction
CRH09_RS30080	COG0667	Aldo Keto reductase
CRH09_RS30115	COG2226	methyltransferase
CRH09_RS30115	COG3433	isochorismatase activity
CRH09_RS30115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS30120	COG0477	Major facilitator Superfamily
CRH09_RS30130	COG0477	Major facilitator Superfamily
CRH09_RS30165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS30180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRH09_RS30200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CRH09_RS30205	COG1917	Cupin 2, conserved barrel domain protein
CRH09_RS30215	COG3971	2-oxopent-4-enoate hydratase activity
CRH09_RS30220	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CRH09_RS30225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRH09_RS30260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CRH09_RS30395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CRH09_RS30470	COG0501	Belongs to the peptidase M48B family
CRH09_RS30535	COG3547	Transposase (IS116 IS110 IS902 family)
CRH09_RS30545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRH09_RS30670	COG2124	cytochrome p450
CRH09_RS30775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRH09_RS30820	COG0745	RESPONSE REGULATOR receiver
CRH09_RS30825	COG2205	protein histidine kinase activity
CRH09_RS30830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRH09_RS30835	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CRH09_RS30840	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRH09_RS30855	COG1024	Enoyl-CoA hydratase
CRH09_RS30860	COG1024	Enoyl-CoA hydratase
CRH09_RS30865	COG1024	Enoyl-CoA hydratase
CRH09_RS30875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS30880	COG0475	glutathione-regulated potassium exporter activity
CRH09_RS30920	COG2124	cytochrome p450
CRH09_RS30930	COG2124	cytochrome p450
CRH09_RS30935	COG2124	cytochrome p450
CRH09_RS30945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS30945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS30965	COG1132	(ABC) transporter
CRH09_RS31000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS31005	COG0367	asparagine synthase
CRH09_RS31140	COG1993	acr, cog1993
CRH09_RS31190	COG2271	Major facilitator Superfamily
CRH09_RS31205	COG2197	response regulator
CRH09_RS31210	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS31215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRH09_RS31235	COG1970	mechanosensitive ion channel activity
CRH09_RS31240	COG2072	flavoprotein involved in K transport
CRH09_RS31250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS31275	COG1228	amidohydrolase
CRH09_RS31290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CRH09_RS31295	COG2986	histidine ammonia-lyase
CRH09_RS31335	COG0390	transport system, permease component
CRH09_RS31340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CRH09_RS31345	COG0640	Transcriptional regulator
CRH09_RS31385	COG1121	(ABC) transporter
CRH09_RS31400	COG2814	Major facilitator Superfamily
CRH09_RS31410	COG0473	3-isopropylmalate dehydrogenase activity
CRH09_RS31410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CRH09_RS31430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CRH09_RS31445	COG0514	ATP-dependent DNA helicase (RecQ)
CRH09_RS31470	COG2133	pyrroloquinoline quinone binding
CRH09_RS31470	COG5183	chlorophyll binding
CRH09_RS31625	COG2177	Part of the ABC transporter FtsEX involved in
CRH09_RS31630	COG2884	Cell division ATP-binding protein ftsE
CRH09_RS31635	COG0668	transmembrane transport
CRH09_RS31640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRH09_RS31645	COG0483	inositol monophosphate 1-phosphatase activity
CRH09_RS31650	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS31655	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS31660	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS31665	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS31710	COG2807	transmembrane transport
CRH09_RS31720	COG0753	catalase activity
CRH09_RS31725	COG0028	Belongs to the TPP enzyme family
CRH09_RS31730	COG1024	Enoyl-CoA hydratase
CRH09_RS31735	COG1024	Enoyl-CoA hydratase
CRH09_RS31740	COG1024	Enoyl-CoA hydratase
CRH09_RS31760	COG0546	phosphoglycolate phosphatase activity
CRH09_RS31765	COG0246	Mannitol dehydrogenase
CRH09_RS31780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRH09_RS31790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CRH09_RS31795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CRH09_RS31800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CRH09_RS31810	COG0745	RESPONSE REGULATOR receiver
CRH09_RS31830	COG4106	trans-aconitate 2-methyltransferase activity
CRH09_RS31850	COG2807	transmembrane transport
CRH09_RS31855	COG0747	negative chemotaxis
CRH09_RS31860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS31870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRH09_RS31885	COG0686	Belongs to the AlaDH PNT family
CRH09_RS31905	COG1595	DNA-templated transcription, initiation
CRH09_RS31930	COG1802	Transcriptional regulator
CRH09_RS31935	COG2814	Major facilitator Superfamily
CRH09_RS31990	COG0285	dihydrofolate synthase activity
CRH09_RS32005	COG0653	protein targeting
CRH09_RS32020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CRH09_RS32025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRH09_RS32035	COG1388	LysM domain
CRH09_RS32040	COG1615	UPF0182 protein
CRH09_RS32055	COG3480	Lon protease (S16) C-terminal proteolytic domain
CRH09_RS32070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRH09_RS32100	COG1846	Transcriptional regulator
CRH09_RS32135	COG1074	ATP-dependent DNA helicase activity
CRH09_RS32140	COG0596	Alpha beta hydrolase
CRH09_RS32145	COG3695	enzyme binding
CRH09_RS32160	COG0746	molybdenum cofactor guanylyltransferase activity
CRH09_RS32200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CRH09_RS32290	COG0667	Aldo Keto reductase
CRH09_RS32315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CRH09_RS32315	COG2146	nitrite reductase [NAD(P)H] activity
CRH09_RS32325	COG2186	Transcriptional regulator
CRH09_RS32330	COG2223	nitrite transmembrane transporter activity
CRH09_RS32370	COG0513	Belongs to the DEAD box helicase family
CRH09_RS32385	COG0406	alpha-ribazole phosphatase activity
CRH09_RS32400	COG1597	lipid kinase activity
CRH09_RS32415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CRH09_RS32425	COG1595	DNA-templated transcription, initiation
CRH09_RS32430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CRH09_RS32440	COG0477	Major facilitator Superfamily
CRH09_RS32450	COG2135	peptidase activity
CRH09_RS32460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRH09_RS32495	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS32510	COG0653	protein targeting
CRH09_RS32550	COG0183	Belongs to the thiolase family
CRH09_RS32555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CRH09_RS32565	COG5401	PFAM Sporulation and spore germination
CRH09_RS32570	COG5002	protein histidine kinase activity
CRH09_RS32585	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CRH09_RS32590	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CRH09_RS32595	COG4565	transcriptional regulatory protein
CRH09_RS32600	COG3290	protein histidine kinase activity
CRH09_RS32605	COG1301	dicarboxylic acid transport
CRH09_RS32615	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CRH09_RS32615	COG0778	Nitroreductase
CRH09_RS32620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CRH09_RS32650	COG1482	cell wall glycoprotein biosynthetic process
CRH09_RS32690	COG1316	TRANSCRIPTIONal
CRH09_RS32705	COG2272	Belongs to the type-B carboxylesterase lipase family
CRH09_RS32715	COG3012	SEC-C Motif Domain Protein
CRH09_RS32725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CRH09_RS32735	COG0714	Associated with various cellular activities
CRH09_RS32740	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CRH09_RS32745	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CRH09_RS32815	COG1136	(ABC) transporter
CRH09_RS32815	COG0577	efflux transmembrane transporter activity
CRH09_RS32820	COG1136	(ABC) transporter
CRH09_RS32820	COG0577	efflux transmembrane transporter activity
CRH09_RS32825	COG0671	phosphoesterase, PA-phosphatase related
CRH09_RS32855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CRH09_RS32865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRH09_RS32870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRH09_RS32895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS32910	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS32945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CRH09_RS32950	COG3973	AAA domain
CRH09_RS32975	COG0667	Aldo Keto reductase
CRH09_RS32985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CRH09_RS33015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CRH09_RS33040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CRH09_RS33040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CRH09_RS33045	COG1024	Enoyl-CoA hydratase
CRH09_RS33050	COG0435	Glutathione S-transferase
CRH09_RS33070	COG1131	(ABC) transporter
CRH09_RS33095	COG0567	Dehydrogenase, E1 component
CRH09_RS33095	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH09_RS33115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRH09_RS33120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CRH09_RS33120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CRH09_RS33125	COG1461	Dihydroxyacetone kinase
CRH09_RS33130	COG2376	Dihydroxyacetone kinase
CRH09_RS33160	COG1309	transcriptional regulator
CRH09_RS33200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CRH09_RS33210	COG0697	spore germination
CRH09_RS33215	COG2124	cytochrome p450
CRH09_RS33220	COG2124	cytochrome p450
CRH09_RS33230	COG4585	Histidine kinase
CRH09_RS33245	COG0745	RESPONSE REGULATOR receiver
CRH09_RS33250	COG2205	protein histidine kinase activity
CRH09_RS33260	COG3345	alpha-galactosidase
CRH09_RS33270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CRH09_RS33280	COG0613	PHP domain protein
CRH09_RS33295	COG2301	Belongs to the HpcH HpaI aldolase family
CRH09_RS33300	COG2239	Acts as a magnesium transporter
CRH09_RS33345	COG0519	Catalyzes the synthesis of GMP from XMP
CRH09_RS33355	COG2226	methyltransferase
CRH09_RS33360	COG0297	glycogen (starch) synthase activity
CRH09_RS33365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CRH09_RS33375	COG3559	Exporter of polyketide antibiotics
CRH09_RS33380	COG1131	(ABC) transporter
CRH09_RS33385	COG1309	transcriptional regulator
CRH09_RS33400	COG5662	AntiSigma factor
CRH09_RS33405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRH09_RS33420	COG0463	Glycosyl transferase, family 2
CRH09_RS33425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRH09_RS33430	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS33435	COG1611	Belongs to the LOG family
CRH09_RS33440	COG1611	Belongs to the LOG family
CRH09_RS33450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRH09_RS33470	COG1012	belongs to the aldehyde dehydrogenase family
CRH09_RS33475	COG0506	proline dehydrogenase activity
CRH09_RS33495	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS33525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRH09_RS33540	COG0531	amino acid
CRH09_RS33555	COG0642	Histidine kinase
CRH09_RS33565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRH09_RS33570	COG0747	negative chemotaxis
CRH09_RS33575	COG1217	gtp-binding protein TYPA
CRH09_RS33585	COG2154	pterin-4-alpha-carbinolamine dehydratase
CRH09_RS33590	COG1051	belongs to the nudix hydrolase family
CRH09_RS33605	COG3757	hydrolase, family 25
CRH09_RS33630	COG1174	glycine betaine transport
CRH09_RS33680	COG0012	GTP binding
CRH09_RS33740	COG0395	ABC-type sugar transport system, permease component
CRH09_RS33745	COG1175	transmembrane transport
CRH09_RS33755	COG1966	Carbon starvation protein
CRH09_RS33770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRH09_RS33775	COG0419	ATPase involved in DNA repair
CRH09_RS33780	COG0420	3'-5' exonuclease activity
CRH09_RS33785	COG1322	Protein conserved in bacteria
CRH09_RS33795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CRH09_RS33805	COG1570	exodeoxyribonuclease VII activity
CRH09_RS33810	COG1722	exodeoxyribonuclease VII activity
CRH09_RS33855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CRH09_RS33860	COG3189	MarR family transcriptional regulator
CRH09_RS33935	COG4977	sequence-specific DNA binding
CRH09_RS33965	COG0339	signal peptide processing
CRH09_RS33980	COG1846	Transcriptional regulator
CRH09_RS33985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRH09_RS34000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRH09_RS34005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CRH09_RS34010	COG1073	alpha beta
CRH09_RS34030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CRH09_RS34030	COG0116	Belongs to the methyltransferase superfamily
CRH09_RS34035	COG0789	Transcriptional regulator
CRH09_RS34040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRH09_RS34050	COG1072	(Pantothenic acid kinase))
CRH09_RS34070	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS34130	COG1280	lysine exporter protein (LysE YggA)
CRH09_RS34135	COG1522	sequence-specific DNA binding
CRH09_RS34155	COG3629	intracellular signal transduction
CRH09_RS34155	COG3903	Transcriptional regulator
CRH09_RS34165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CRH09_RS34175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRH09_RS34185	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS34195	COG0668	transmembrane transport
CRH09_RS34200	COG5412	phage tail tape measure protein
CRH09_RS34200	COG3953	SLT domain
CRH09_RS34205	COG3180	Ammonia monooxygenase
CRH09_RS34220	COG2755	lipolytic protein G-D-S-L family
CRH09_RS34225	COG0183	Belongs to the thiolase family
CRH09_RS34230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CRH09_RS34240	COG2813	Specifically methylates the guanine in position
CRH09_RS34250	COG3537	Alpha-1,2-mannosidase
CRH09_RS34270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRH09_RS34275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRH09_RS34280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRH09_RS34285	COG0488	(ABC) transporter
CRH09_RS34295	COG2382	esterase
CRH09_RS34325	COG2267	carboxylic ester hydrolase activity
CRH09_RS34330	COG2226	methyltransferase
CRH09_RS34345	COG3835	regulator
CRH09_RS34350	COG3961	Belongs to the TPP enzyme family
CRH09_RS34360	COG0596	Alpha beta hydrolase
CRH09_RS34365	COG0531	amino acid
CRH09_RS34380	COG0477	Major facilitator Superfamily
CRH09_RS34415	COG1073	alpha beta
CRH09_RS34435	COG1309	transcriptional regulator
CRH09_RS34455	COG0531	amino acid
CRH09_RS34480	COG5650	phosphatidylinositol metabolic process
CRH09_RS34490	COG0586	Pfam SNARE associated Golgi protein
CRH09_RS34495	COG0671	phosphoesterase, PA-phosphatase related
CRH09_RS34500	COG2205	protein histidine kinase activity
CRH09_RS34505	COG0745	RESPONSE REGULATOR receiver
CRH09_RS34520	COG2079	MmgE PrpD family protein
CRH09_RS34525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CRH09_RS34540	COG3104	oligopeptide transport
CRH09_RS34560	COG0148	phosphopyruvate hydratase activity
CRH09_RS34570	COG4172	Belongs to the ABC transporter superfamily
CRH09_RS34585	COG0747	negative chemotaxis
CRH09_RS34600	COG0019	diaminopimelate decarboxylase activity
CRH09_RS34605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRH09_RS34620	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS34650	COG3956	TIGRFAM MazG family protein
CRH09_RS34675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRH09_RS34695	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CRH09_RS34700	COG0121	glutamine amidotransferase
CRH09_RS34705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CRH09_RS34710	COG3572	ergothioneine biosynthetic process
CRH09_RS34715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRH09_RS34720	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS34725	COG0193	aminoacyl-tRNA hydrolase activity
CRH09_RS34730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CRH09_RS34740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CRH09_RS34765	COG0488	(ABC) transporter
CRH09_RS34770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CRH09_RS34785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRH09_RS34800	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS34805	COG3583	domain protein
CRH09_RS34810	COG0084	hydrolase, TatD family'
CRH09_RS34825	COG1725	Transcriptional regulator
CRH09_RS34830	COG2235	arginine
CRH09_RS34845	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS34900	COG4974	Belongs to the 'phage' integrase family
CRH09_RS34970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS35000	COG1715	Restriction endonuclease
CRH09_RS35020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS35050	COG1309	transcriptional regulator
CRH09_RS35070	COG0531	amino acid
CRH09_RS35075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CRH09_RS35080	COG0596	Alpha beta hydrolase
CRH09_RS35085	COG3903	Transcriptional regulator
CRH09_RS35085	COG3629	intracellular signal transduction
CRH09_RS35140	COG0494	nUDIX hydrolase
CRH09_RS35155	COG0300	oxidoreductase activity
CRH09_RS35180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CRH09_RS35210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CRH09_RS35265	COG1605	Chorismate mutase
CRH09_RS35290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRH09_RS35290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRH09_RS35305	COG0356	it plays a direct role in the translocation of protons across the membrane
CRH09_RS35320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRH09_RS35330	COG3285	dna ligase
CRH09_RS35330	COG1793	dna ligase
CRH09_RS35335	COG2813	Specifically methylates the guanine in position
CRH09_RS35340	COG4214	carbohydrate transport
CRH09_RS35350	COG4213	ABC transporter substrate-binding protein
CRH09_RS35355	COG1940	carbohydrate kinase activity
CRH09_RS35365	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS35370	COG1846	Transcriptional regulator
CRH09_RS35385	COG2706	6-phosphogluconolactonase activity
CRH09_RS35390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRH09_RS35405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRH09_RS35415	COG4948	Mandelate Racemase Muconate Lactonizing
CRH09_RS35440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRH09_RS35450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CRH09_RS35455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CRH09_RS35470	COG1970	mechanosensitive ion channel activity
CRH09_RS35485	COG0315	cyclic pyranopterin monophosphate synthase activity
CRH09_RS35485	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRH09_RS35490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRH09_RS35495	COG2205	protein histidine kinase activity
CRH09_RS35500	COG0745	RESPONSE REGULATOR receiver
CRH09_RS35505	COG5002	protein histidine kinase activity
CRH09_RS35510	COG2018	Roadblock/LC7 domain
CRH09_RS35550	COG0254	rRNA binding
CRH09_RS35560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRH09_RS35565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRH09_RS35570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRH09_RS35575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRH09_RS35615	COG0045	succinate-CoA ligase (ADP-forming) activity
CRH09_RS35620	COG0739	heme binding
CRH09_RS35640	COG0166	Belongs to the GPI family
CRH09_RS35650	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS35660	COG1024	Enoyl-CoA hydratase
CRH09_RS35680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CRH09_RS35695	COG2272	Belongs to the type-B carboxylesterase lipase family
CRH09_RS35700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CRH09_RS35715	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CRH09_RS35730	COG2837	iron assimilation
CRH09_RS35760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRH09_RS35760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CRH09_RS35785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CRH09_RS35810	COG3617	BRO family, N-terminal domain
CRH09_RS35990	COG3941	tape measure
CRH09_RS36060	COG0494	nUDIX hydrolase
CRH09_RS36065	COG0477	Major facilitator Superfamily
CRH09_RS36070	COG1309	transcriptional regulator
CRH09_RS36140	COG0442	prolyl-tRNA aminoacylation
CRH09_RS36155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRH09_RS36160	COG2318	DinB family
CRH09_RS36230	COG2197	response regulator
CRH09_RS36235	COG3290	protein histidine kinase activity
CRH09_RS36245	COG1136	(ABC) transporter
CRH09_RS36260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRH09_RS36270	COG2030	dehydratase
CRH09_RS36275	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS36285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRH09_RS36295	COG1505	serine-type exopeptidase activity
CRH09_RS36320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CRH09_RS36355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRH09_RS36390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRH09_RS36395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CRH09_RS36400	COG0049	tRNA binding
CRH09_RS36405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRH09_RS36420	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CRH09_RS36445	COG3953	SLT domain
CRH09_RS36445	COG5280	Phage tail tape measure protein TP901
CRH09_RS36480	COG1846	Transcriptional regulator
CRH09_RS36485	COG3384	dioxygenase
CRH09_RS36490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRH09_RS36495	COG1846	Transcriptional regulator
CRH09_RS36520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRH09_RS36525	COG0085	RNA polymerase activity
CRH09_RS36545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRH09_RS36570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS36575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS36585	COG0222	ribosome binding
CRH09_RS36590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRH09_RS36595	COG0081	regulation of translation
CRH09_RS36600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRH09_RS36610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRH09_RS36625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRH09_RS36645	COG1666	GTP binding
CRH09_RS36650	COG0501	Belongs to the peptidase M48B family
CRH09_RS36655	COG0142	geranyltranstransferase activity
CRH09_RS36670	COG0346	lactoylglutathione lyase activity
CRH09_RS36685	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS36695	COG1309	transcriptional regulator
CRH09_RS36700	COG2226	methyltransferase
CRH09_RS36705	COG0243	molybdopterin cofactor binding
CRH09_RS36710	COG0667	Aldo Keto reductase
CRH09_RS36715	COG1309	transcriptional regulator
CRH09_RS36730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CRH09_RS36800	COG1950	PFAM Membrane protein of
CRH09_RS36805	COG0542	response to heat
CRH09_RS36830	COG0583	DNA-binding transcription factor activity
CRH09_RS36840	COG0583	DNA-binding transcription factor activity
CRH09_RS36865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRH09_RS36870	COG1333	cytochrome c biogenesis protein
CRH09_RS36875	COG0785	Cytochrome C biogenesis protein
CRH09_RS36885	COG0406	alpha-ribazole phosphatase activity
CRH09_RS36890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CRH09_RS36940	COG0181	hydroxymethylbilane synthase activity
CRH09_RS36945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRH09_RS36950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CRH09_RS37025	COG0745	RESPONSE REGULATOR receiver
CRH09_RS37030	COG5002	protein histidine kinase activity
CRH09_RS37040	COG0588	phosphoglycerate mutase activity
CRH09_RS37055	COG0438	transferase activity, transferring glycosyl groups
CRH09_RS37060	COG2267	carboxylic ester hydrolase activity
CRH09_RS37075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CRH09_RS37105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CRH09_RS37120	COG0596	Alpha beta hydrolase
CRH09_RS37145	COG2733	membrane
CRH09_RS37155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CRH09_RS37160	COG3268	Saccharopine dehydrogenase
CRH09_RS37165	COG2226	methyltransferase
CRH09_RS37185	COG2326	polyphosphate kinase activity
CRH09_RS37200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRH09_RS37240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CRH09_RS37250	COG2224	Isocitrate lyase
CRH09_RS37260	COG2080	2 iron, 2 sulfur cluster binding
CRH09_RS37260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CRH09_RS37305	COG1116	anion transmembrane transporter activity
CRH09_RS37355	COG0395	ABC-type sugar transport system, permease component
CRH09_RS37375	COG1793	dna ligase
CRH09_RS37405	COG0702	epimerase
CRH09_RS37410	COG1733	regulation of RNA biosynthetic process
CRH09_RS37420	COG1505	serine-type exopeptidase activity
CRH09_RS37435	COG1309	transcriptional regulator
CRH09_RS37455	COG0459	protein refolding
CRH09_RS37465	COG4106	trans-aconitate 2-methyltransferase activity
CRH09_RS37475	COG1252	NADH dehydrogenase
CRH09_RS37480	COG1595	DNA-templated transcription, initiation
CRH09_RS37525	COG0688	phosphatidylethanolamine metabolic process
CRH09_RS37535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRH09_RS37545	COG2111	Na H antiporter
CRH09_RS37545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRH09_RS37555	COG0651	ATP synthesis coupled electron transport
CRH09_RS37580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CRH09_RS37620	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS37645	COG1073	alpha beta
CRH09_RS37650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRH09_RS37655	COG0523	cobalamin synthesis protein
CRH09_RS37660	COG0351	phosphomethylpyrimidine kinase
CRH09_RS37695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CRH09_RS37700	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS37720	COG1131	(ABC) transporter
CRH09_RS37725	COG2022	thiamine diphosphate biosynthetic process
CRH09_RS37735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRH09_RS37735	COG2022	thiamine diphosphate biosynthetic process
CRH09_RS37740	COG0352	thiamine-phosphate diphosphorylase activity
CRH09_RS37755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRH09_RS37760	COG0515	serine threonine protein kinase
CRH09_RS37765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CRH09_RS37780	COG0583	DNA-binding transcription factor activity
CRH09_RS37790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS37805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRH09_RS37840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CRH09_RS37845	COG2197	response regulator
CRH09_RS37865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH09_RS37870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRH09_RS37880	COG1994	Peptidase M50
CRH09_RS37885	COG4129	membrane
CRH09_RS37910	COG0586	Pfam SNARE associated Golgi protein
CRH09_RS37940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRH09_RS37980	COG4585	Histidine kinase
CRH09_RS37985	COG2197	response regulator
CRH09_RS38025	COG0542	response to heat
CRH09_RS38030	COG2130	NADP-dependent
CRH09_RS38050	COG0789	Transcriptional regulator
CRH09_RS38055	COG0484	heat shock protein binding
CRH09_RS38060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRH09_RS38065	COG0443	Heat shock 70 kDa protein
CRH09_RS38075	COG1063	alcohol dehydrogenase
CRH09_RS38135	COG0247	lactate metabolic process
CRH09_RS38135	COG2181	nitrate reductase activity
CRH09_RS38185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CRH09_RS38200	COG0277	FAD linked oxidase domain protein
CRH09_RS38205	COG0717	Belongs to the dCTP deaminase family
CRH09_RS38210	COG2860	membrane
CRH09_RS38255	COG0604	alcohol dehydrogenase
CRH09_RS38285	COG0442	prolyl-tRNA aminoacylation
CRH09_RS38335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CRH09_RS38400	COG0596	Alpha beta hydrolase
CRH09_RS38405	COG1024	Enoyl-CoA hydratase
CRH09_RS38430	COG1960	acyl-CoA dehydrogenase activity
CRH09_RS38445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CRH09_RS38450	COG1472	Belongs to the glycosyl hydrolase 3 family
CRH09_RS38455	COG1309	transcriptional regulator
CRH09_RS38460	COG2030	dehydratase
CRH09_RS38465	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS38470	COG0183	Belongs to the thiolase family
CRH09_RS38500	COG4981	capsule polysaccharide biosynthetic process
CRH09_RS38525	COG0297	glycogen (starch) synthase activity
CRH09_RS38530	COG0500	methyltransferase
CRH09_RS38545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CRH09_RS38565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRH09_RS38580	COG0508	dehydrogenase complex catalyzes the overall conversion of
CRH09_RS38580	COG0596	Alpha beta hydrolase
CRH09_RS38620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CRH09_RS38635	COG1476	TRANSCRIPTIONal
CRH09_RS38640	COG2084	Dehydrogenase
CRH09_RS38645	COG1733	regulation of RNA biosynthetic process
CRH09_RS38650	COG1929	Belongs to the glycerate kinase type-1 family
CRH09_RS38665	COG1678	Uncharacterized ACR, COG1678
CRH09_RS38685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRH09_RS38690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRH09_RS38700	COG0028	Belongs to the TPP enzyme family
CRH09_RS38730	COG0495	leucyl-tRNA aminoacylation
CRH09_RS38735	COG0726	polysaccharide deacetylase
CRH09_RS38740	COG1028	Short-chain dehydrogenase reductase Sdr
CRH09_RS38745	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CRH09_RS38750	COG3757	hydrolase, family 25
CRH09_RS38765	COG0765	amino acid transport
CRH09_RS38775	COG3842	ATPase activity
CRH09_RS38785	COG0183	Belongs to the thiolase family
CRH09_RS38790	COG4948	Mandelate Racemase Muconate Lactonizing
CRH09_RS38820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRH09_RS38840	COG1695	Transcriptional regulator
CRH09_RS38850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CRH09_RS38875	COG1902	pentaerythritol trinitrate reductase activity
CRH09_RS38880	COG0789	Transcriptional regulator
CRH09_RS38900	COG0360	Binds together with S18 to 16S ribosomal RNA
CRH09_RS38910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRH09_RS38915	COG0359	binds to the 23S rRNA
CRH09_RS38960	COG0583	DNA-binding transcription factor activity
CRH09_RS38975	COG1335	isochorismatase
CRH09_RS38980	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS39000	COG0318	PFAM AMP-dependent synthetase and ligase
CRH09_RS39010	COG0475	glutathione-regulated potassium exporter activity
CRH09_RS39010	COG0569	domain protein
CRH09_RS39040	COG0596	Alpha beta hydrolase
CRH09_RS39060	COG1053	succinate dehydrogenase
CRH09_RS39120	COG1278	Cold shock
CRH09_RS39130	COG1175	transmembrane transport
CRH09_RS39135	COG0395	ABC-type sugar transport system, permease component
CRH09_RS39165	COG0277	FAD linked oxidase domain protein
CRH09_RS39165	COG0247	lactate metabolic process
CRH09_RS39175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRH09_RS39180	COG1132	(ABC) transporter
CRH09_RS39200	COG5504	Zn-dependent protease
CRH09_RS39230	COG0604	alcohol dehydrogenase
CRH09_RS39235	COG1024	Enoyl-CoA hydratase
CRH09_RS39255	COG5650	phosphatidylinositol metabolic process
CRH09_RS39280	COG1063	alcohol dehydrogenase
CRH09_RS39300	COG0579	oxidoreductase
CRH09_RS39310	COG0328	RNA-DNA hybrid ribonuclease activity
CRH09_RS39350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS39355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRH09_RS39365	COG0477	Major facilitator Superfamily
CRH09_RS39375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CRH09_RS39380	COG2124	cytochrome p450
CRH09_RS39385	COG1376	ErfK ybiS ycfS ynhG family protein
CRH09_RS39405	COG3842	ATPase activity
CRH09_RS39410	COG3590	peptidase
CRH09_RS39485	COG0617	tRNA 3'-terminal CCA addition
CRH09_RS39505	COG1595	DNA-templated transcription, initiation
CRH09_RS39525	COG3409	Peptidoglycan-binding domain 1 protein
CRH09_RS39525	COG0860	N-Acetylmuramoyl-L-alanine amidase
CRH09_RS39540	COG1192	Involved in chromosome partitioning
CRH09_RS39545	COG0357	Ribosomal RNA small subunit methyltransferase G
CRH09_RS39555	COG0706	membrane insertase activity
CRH09_RS39560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CRH09_RS39565	COG0594	ribonuclease P activity
CRH09_RS39570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRH09_RS39640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRH09_RS39910	COG1396	sequence-specific DNA binding