locus-tag	class	description
G5V58_RS00020	COG1414	Transcriptional regulator
G5V58_RS00040	COG0519	Catalyzes the synthesis of GMP from XMP
G5V58_RS00045	COG2020	methyltransferase activity
G5V58_RS00060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G5V58_RS00065	COG0277	FAD linked oxidase domain protein
G5V58_RS00075	COG0154	amidase activity
G5V58_RS00090	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G5V58_RS00100	COG2030	dehydratase
G5V58_RS00110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G5V58_RS00120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G5V58_RS00125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G5V58_RS00140	COG0250	Participates in transcription elongation, termination and antitermination
G5V58_RS00145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G5V58_RS00150	COG0081	regulation of translation
G5V58_RS00155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G5V58_RS00160	COG0222	ribosome binding
G5V58_RS00165	COG1672	PFAM Archaeal ATPase
G5V58_RS00165	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G5V58_RS00195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G5V58_RS00200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G5V58_RS00240	COG0484	heat shock protein binding
G5V58_RS00245	COG0085	RNA polymerase activity
G5V58_RS00250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G5V58_RS00255	COG0583	DNA-binding transcription factor activity
G5V58_RS00270	COG2814	Major facilitator Superfamily
G5V58_RS00290	COG0644	oxidoreductase
G5V58_RS00300	COG0494	nUDIX hydrolase
G5V58_RS00310	COG0247	lactate metabolic process
G5V58_RS00310	COG0277	FAD linked oxidase domain protein
G5V58_RS00330	COG0702	epimerase
G5V58_RS00350	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G5V58_RS00360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G5V58_RS00375	COG0222	ribosome binding
G5V58_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS00405	COG0259	pyridoxamine-phosphate oxidase activity
G5V58_RS00435	COG2197	response regulator
G5V58_RS00440	COG4181	ATPase activity
G5V58_RS00455	COG0477	Major facilitator Superfamily
G5V58_RS00465	COG0366	Alpha amylase catalytic
G5V58_RS00480	COG0415	Belongs to the DNA photolyase family
G5V58_RS00500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G5V58_RS00515	COG3268	Saccharopine dehydrogenase
G5V58_RS00535	COG1595	DNA-templated transcription, initiation
G5V58_RS00555	COG0745	RESPONSE REGULATOR receiver
G5V58_RS00575	COG4221	oxidoreductase activity
G5V58_RS00610	COG1316	TRANSCRIPTIONal
G5V58_RS00620	COG1970	mechanosensitive ion channel activity
G5V58_RS00635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G5V58_RS00650	COG0315	cyclic pyranopterin monophosphate synthase activity
G5V58_RS00705	COG2197	response regulator
G5V58_RS00730	COG0596	Alpha beta hydrolase
G5V58_RS00735	COG0084	hydrolase, TatD family'
G5V58_RS00740	COG3583	domain protein
G5V58_RS00745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G5V58_RS00750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G5V58_RS00755	COG0488	(ABC) transporter
G5V58_RS00800	COG0494	nUDIX hydrolase
G5V58_RS00810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G5V58_RS00840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G5V58_RS00850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G5V58_RS00855	COG4221	oxidoreductase activity
G5V58_RS00860	COG0405	Gamma-glutamyltransferase
G5V58_RS00870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G5V58_RS00900	COG1072	(Pantothenic acid kinase))
G5V58_RS00910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G5V58_RS00925	COG2205	protein histidine kinase activity
G5V58_RS00925	COG0784	Response regulator, receiver
G5V58_RS00925	COG5002	protein histidine kinase activity
G5V58_RS00950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G5V58_RS00975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G5V58_RS00990	COG4585	Histidine kinase
G5V58_RS00995	COG2197	response regulator
G5V58_RS01005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G5V58_RS01010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G5V58_RS01015	COG3291	Pkd domain containing protein
G5V58_RS01120	COG3265	gluconokinase activity
G5V58_RS01140	COG0297	glycogen (starch) synthase activity
G5V58_RS01150	COG3663	DNA glycosylase
G5V58_RS01195	COG4129	membrane
G5V58_RS01205	COG4585	Histidine kinase
G5V58_RS01210	COG2197	response regulator
G5V58_RS01215	COG1136	(ABC) transporter
G5V58_RS01215	COG0577	efflux transmembrane transporter activity
G5V58_RS01240	COG1136	(ABC) transporter
G5V58_RS01245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G5V58_RS01250	COG3557	Belongs to the UPF0374 family
G5V58_RS01265	COG2072	flavoprotein involved in K transport
G5V58_RS01270	COG1309	transcriptional regulator
G5V58_RS01275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G5V58_RS01290	COG2205	protein histidine kinase activity
G5V58_RS01295	COG0745	RESPONSE REGULATOR receiver
G5V58_RS01300	COG1595	DNA-templated transcription, initiation
G5V58_RS01310	COG2205	protein histidine kinase activity
G5V58_RS01315	COG0745	RESPONSE REGULATOR receiver
G5V58_RS01330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G5V58_RS01340	COG1643	Atp-dependent helicase
G5V58_RS01365	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G5V58_RS01375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G5V58_RS01395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS01410	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G5V58_RS01425	COG4585	Histidine kinase
G5V58_RS01430	COG2197	response regulator
G5V58_RS01450	COG3253	May function as heme-dependent peroxidase
G5V58_RS01460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G5V58_RS01480	COG1061	Type III restriction enzyme res subunit
G5V58_RS01490	COG0477	Major facilitator Superfamily
G5V58_RS01505	COG0631	protein serine/threonine phosphatase activity
G5V58_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS01590	COG1278	Cold shock
G5V58_RS01595	COG2814	Major facilitator Superfamily
G5V58_RS01610	COG2252	PERMEase
G5V58_RS01625	COG2211	Major facilitator Superfamily
G5V58_RS01630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G5V58_RS01635	COG0049	tRNA binding
G5V58_RS01640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G5V58_RS01645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G5V58_RS01665	COG1136	(ABC) transporter
G5V58_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS01690	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS01745	COG1940	carbohydrate kinase activity
G5V58_RS01750	COG1472	Belongs to the glycosyl hydrolase 3 family
G5V58_RS01755	COG0443	Heat shock 70 kDa protein
G5V58_RS01760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G5V58_RS01765	COG0484	heat shock protein binding
G5V58_RS01780	COG3118	belongs to the thioredoxin family
G5V58_RS01805	COG3119	arylsulfatase activity
G5V58_RS01810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G5V58_RS01885	COG1309	transcriptional regulator
G5V58_RS01890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G5V58_RS01920	COG5002	protein histidine kinase activity
G5V58_RS01940	COG2815	serine threonine protein kinase
G5V58_RS01940	COG0515	serine threonine protein kinase
G5V58_RS01945	COG1132	(ABC) transporter
G5V58_RS01955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G5V58_RS02020	COG0714	Associated with various cellular activities
G5V58_RS02050	COG0051	transcription antitermination factor activity, RNA binding
G5V58_RS02055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G5V58_RS02060	COG0088	Forms part of the polypeptide exit tunnel
G5V58_RS02065	COG0089	rRNA binding
G5V58_RS02070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G5V58_RS02075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G5V58_RS02080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G5V58_RS02085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G5V58_RS02090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G5V58_RS02095	COG0255	Belongs to the universal ribosomal protein uL29 family
G5V58_RS02100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G5V58_RS02105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G5V58_RS02110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G5V58_RS02115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G5V58_RS02120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G5V58_RS02125	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G5V58_RS02130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G5V58_RS02135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G5V58_RS02140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G5V58_RS02145	COG1841	ribosomal large subunit assembly
G5V58_RS02150	COG0200	Binds to the 23S rRNA
G5V58_RS02160	COG0563	adenylate kinase activity
G5V58_RS02170	COG1309	transcriptional regulator
G5V58_RS02175	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS02220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS02225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G5V58_RS02230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G5V58_RS02235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G5V58_RS02240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G5V58_RS02245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G5V58_RS02250	COG0202	RNA polymerase activity
G5V58_RS02255	COG0203	ribosomal protein L17
G5V58_RS02280	COG0101	tRNA pseudouridine synthase activity
G5V58_RS02285	COG2813	Specifically methylates the guanine in position
G5V58_RS02325	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS02345	COG0542	response to heat
G5V58_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS02365	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS02370	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS02375	COG1595	DNA-templated transcription, initiation
G5V58_RS02400	COG1175	transmembrane transport
G5V58_RS02405	COG0395	ABC-type sugar transport system, permease component
G5V58_RS02410	COG0488	(ABC) transporter
G5V58_RS02420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5V58_RS02435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5V58_RS02445	COG3511	phospholipase C
G5V58_RS02485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G5V58_RS02490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G5V58_RS02550	COG1072	(Pantothenic acid kinase))
G5V58_RS02555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G5V58_RS02560	COG0736	holo-[acyl-carrier-protein] synthase activity
G5V58_RS02575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G5V58_RS02585	COG0802	atpase or kinase
G5V58_RS02590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G5V58_RS02595	COG1214	PFAM Peptidase M22, glycoprotease
G5V58_RS02595	COG0456	acetyltransferase
G5V58_RS02605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G5V58_RS02620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G5V58_RS02635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G5V58_RS02640	COG0459	protein refolding
G5V58_RS02665	COG0516	GMP reductase activity
G5V58_RS02685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G5V58_RS02715	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS02745	COG3842	ATPase activity
G5V58_RS02800	COG1309	transcriptional regulator
G5V58_RS02805	COG2050	protein possibly involved in aromatic compounds catabolism
G5V58_RS02810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G5V58_RS02815	COG2151	metal-sulfur cluster biosynthetic enzyme
G5V58_RS02820	COG3396	Phenylacetate-CoA oxygenase
G5V58_RS02825	COG3460	Phenylacetate-CoA oxygenase
G5V58_RS02830	COG3396	Phenylacetate-CoA oxygenase
G5V58_RS02835	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS02835	COG2030	dehydratase
G5V58_RS02850	COG0477	Major facilitator Superfamily
G5V58_RS02865	COG0519	Catalyzes the synthesis of GMP from XMP
G5V58_RS02865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G5V58_RS02900	COG3629	intracellular signal transduction
G5V58_RS02900	COG3903	Transcriptional regulator
G5V58_RS02925	COG1136	(ABC) transporter
G5V58_RS02925	COG0577	efflux transmembrane transporter activity
G5V58_RS02930	COG1136	(ABC) transporter
G5V58_RS02945	COG2197	response regulator
G5V58_RS02955	COG2226	methyltransferase
G5V58_RS02955	COG0596	Alpha beta hydrolase
G5V58_RS02955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G5V58_RS02985	COG1573	uracil-dna glycosylase
G5V58_RS03000	COG1070	Carbohydrate kinase
G5V58_RS03020	COG4214	carbohydrate transport
G5V58_RS03030	COG4213	ABC transporter substrate-binding protein
G5V58_RS03040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G5V58_RS03045	COG2409	Drug exporters of the RND superfamily
G5V58_RS03050	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS03110	COG2340	Cysteine-rich secretory protein family
G5V58_RS03120	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G5V58_RS03140	COG2884	Cell division ATP-binding protein ftsE
G5V58_RS03145	COG2177	Part of the ABC transporter FtsEX involved in
G5V58_RS03155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G5V58_RS03185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G5V58_RS03205	COG4638	Rieske (2fe-2S)
G5V58_RS03210	COG1024	Enoyl-CoA hydratase
G5V58_RS03215	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS03235	COG1176	ABC-type spermidine putrescine transport system, permease component I
G5V58_RS03240	COG1177	transmembrane transport
G5V58_RS03245	COG3842	ATPase activity
G5V58_RS03295	COG0537	adenosine 5'-monophosphoramidase activity
G5V58_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS03310	COG1470	cell adhesion involved in biofilm formation
G5V58_RS03315	COG1309	transcriptional regulator
G5V58_RS03325	COG1678	Uncharacterized ACR, COG1678
G5V58_RS03365	COG3185	4-Hydroxyphenylpyruvate dioxygenase
G5V58_RS03385	COG0737	Belongs to the 5'-nucleotidase family
G5V58_RS03400	COG1024	Enoyl-CoA hydratase
G5V58_RS03405	COG1335	isochorismatase
G5V58_RS03420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G5V58_RS03465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G5V58_RS03475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G5V58_RS03480	COG1234	tRNA 3'-trailer cleavage
G5V58_RS03485	COG2197	response regulator
G5V58_RS03525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G5V58_RS03530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G5V58_RS03565	COG1122	ATPase activity
G5V58_RS03575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G5V58_RS03580	COG0723	plastoquinol--plastocyanin reductase activity
G5V58_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G5V58_RS03585	COG1295	ribonuclease BN
G5V58_RS03600	COG3467	pyridoxamine 5'-phosphate
G5V58_RS03635	COG2226	methyltransferase
G5V58_RS03690	COG0747	negative chemotaxis
G5V58_RS03700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G5V58_RS03705	COG0601	transmembrane transport
G5V58_RS03730	COG1414	Transcriptional regulator
G5V58_RS03735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G5V58_RS03745	COG1414	Transcriptional regulator
G5V58_RS03750	COG0747	negative chemotaxis
G5V58_RS03755	COG0601	transmembrane transport
G5V58_RS03760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G5V58_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS03805	COG1414	Transcriptional regulator
G5V58_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS03830	COG1126	abc transporter atp-binding protein
G5V58_RS03835	COG0765	amino acid transport
G5V58_RS03850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G5V58_RS03870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G5V58_RS03880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G5V58_RS03885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G5V58_RS03890	COG1250	3-hydroxyacyl-CoA dehydrogenase
G5V58_RS03895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G5V58_RS03905	COG0686	Belongs to the AlaDH PNT family
G5V58_RS03915	COG0583	DNA-binding transcription factor activity
G5V58_RS03920	COG0183	Belongs to the thiolase family
G5V58_RS03930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G5V58_RS03935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G5V58_RS04005	COG1053	succinate dehydrogenase
G5V58_RS04030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G5V58_RS04055	COG2197	response regulator
G5V58_RS04060	COG1595	DNA-templated transcription, initiation
G5V58_RS04070	COG0596	Alpha beta hydrolase
G5V58_RS04090	COG0582	viral genome integration into host DNA
G5V58_RS04190	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G5V58_RS04205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G5V58_RS04230	COG2890	protein-(glutamine-N5) methyltransferase activity
G5V58_RS04260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS04290	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS04295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G5V58_RS04310	COG3387	PFAM Glycoside hydrolase 15-related
G5V58_RS04315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G5V58_RS04355	COG1940	carbohydrate kinase activity
G5V58_RS04360	COG1129	ABC transporter
G5V58_RS04365	COG1172	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS04370	COG1879	ABC-type sugar transport system periplasmic component
G5V58_RS04375	COG0673	inositol 2-dehydrogenase activity
G5V58_RS04435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G5V58_RS04460	COG2326	polyphosphate kinase activity
G5V58_RS04480	COG3263	regulation of cellular component size
G5V58_RS04515	COG0006	proline dipeptidase activity
G5V58_RS04555	COG0183	Belongs to the thiolase family
G5V58_RS04560	COG1309	transcriptional regulator
G5V58_RS04570	COG0824	Thioesterase
G5V58_RS04585	COG2346	COG2346, Truncated hemoglobins
G5V58_RS04590	COG1764	response to oxidative stress
G5V58_RS04595	COG0668	transmembrane transport
G5V58_RS04620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G5V58_RS04630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G5V58_RS04635	COG0504	CTP synthase activity
G5V58_RS04640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
G5V58_RS04660	COG1280	lysine exporter protein (LysE YggA)
G5V58_RS04675	COG1595	DNA-templated transcription, initiation
G5V58_RS04680	COG1302	Protein conserved in bacteria
G5V58_RS04730	COG0657	acetylesterase activity
G5V58_RS04735	COG0698	ribose 5-phosphate isomerase
G5V58_RS04770	COG0515	serine threonine protein kinase
G5V58_RS04770	COG2815	serine threonine protein kinase
G5V58_RS04785	COG0714	Associated with various cellular activities
G5V58_RS04795	COG1674	ftsk spoiiie
G5V58_RS04830	COG0740	serine-type endopeptidase activity
G5V58_RS04835	COG0740	serine-type endopeptidase activity
G5V58_RS04840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G5V58_RS04865	COG0525	valine-tRNA ligase activity
G5V58_RS04870	COG0736	holo-[acyl-carrier-protein] synthase activity
G5V58_RS04875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G5V58_RS04885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G5V58_RS04915	COG0285	dihydrofolate synthase activity
G5V58_RS04930	COG0105	UTP biosynthetic process
G5V58_RS04940	COG1077	Cell shape determining protein MreB Mrl
G5V58_RS04955	COG0768	penicillin binding
G5V58_RS04960	COG0772	Belongs to the SEDS family
G5V58_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS04980	COG0387	Pfam Sodium calcium exchanger
G5V58_RS04990	COG0251	oxidation-reduction process
G5V58_RS05025	COG2807	transmembrane transport
G5V58_RS05040	COG1530	ribonuclease E activity
G5V58_RS05045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G5V58_RS05050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G5V58_RS05055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G5V58_RS05060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G5V58_RS05080	COG0482	sulfurtransferase activity
G5V58_RS05090	COG4948	Mandelate Racemase Muconate Lactonizing
G5V58_RS05105	COG0693	protein deglycase activity
G5V58_RS05135	COG3813	Protein conserved in bacteria
G5V58_RS05145	COG4941	Belongs to the sigma-70 factor family
G5V58_RS05165	COG0655	NAD(P)H dehydrogenase (quinone) activity
G5V58_RS05170	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G5V58_RS05175	COG0154	amidase activity
G5V58_RS05180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G5V58_RS05205	COG3845	ABC transporter
G5V58_RS05225	COG5006	permease, DMT superfamily
G5V58_RS05230	COG0531	amino acid
G5V58_RS05235	COG0129	dihydroxy-acid dehydratase activity
G5V58_RS05285	COG1271	oxidase subunit
G5V58_RS05290	COG1294	oxidase, subunit
G5V58_RS05295	COG4988	ABC transporter
G5V58_RS05300	COG2154	pterin-4-alpha-carbinolamine dehydratase
G5V58_RS05315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G5V58_RS05335	COG1131	(ABC) transporter
G5V58_RS05340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G5V58_RS05345	COG0672	)-iron permease
G5V58_RS05355	COG2837	iron assimilation
G5V58_RS05365	COG0488	(ABC) transporter
G5V58_RS05370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G5V58_RS05380	COG2186	Transcriptional regulator
G5V58_RS05385	COG2364	Membrane
G5V58_RS05400	COG0473	3-isopropylmalate dehydrogenase activity
G5V58_RS05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G5V58_RS05430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5V58_RS05440	COG0154	amidase activity
G5V58_RS05470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G5V58_RS05475	COG0156	8-amino-7-oxononanoate synthase activity
G5V58_RS05480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G5V58_RS05485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G5V58_RS05515	COG1876	peptidase activity
G5V58_RS05520	COG0179	Fumarylacetoacetate (FAA) hydrolase
G5V58_RS05525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G5V58_RS05525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G5V58_RS05545	COG0596	Alpha beta hydrolase
G5V58_RS05550	COG2770	Histidine kinase
G5V58_RS05550	COG2208	phosphoserine phosphatase activity
G5V58_RS05570	COG1316	TRANSCRIPTIONal
G5V58_RS05580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G5V58_RS05590	COG1414	Transcriptional regulator
G5V58_RS05595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G5V58_RS05600	COG0066	3-isopropylmalate dehydratase activity
G5V58_RS05610	COG2267	carboxylic ester hydrolase activity
G5V58_RS05615	COG0776	regulation of translation
G5V58_RS05620	COG1920	GTP binding
G5V58_RS05630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G5V58_RS05635	COG0626	cystathionine gamma-synthase activity
G5V58_RS05640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G5V58_RS05645	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS05650	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS05665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G5V58_RS05670	COG1461	Dihydroxyacetone kinase
G5V58_RS05680	COG0742	ribosomal rna small subunit methyltransferase
G5V58_RS05685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G5V58_RS05695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G5V58_RS05700	COG0571	ribonuclease III activity
G5V58_RS05705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G5V58_RS05730	COG0477	Major facilitator Superfamily
G5V58_RS05785	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G5V58_RS05825	COG1472	Belongs to the glycosyl hydrolase 3 family
G5V58_RS05835	COG2720	vancomycin resistance protein
G5V58_RS05840	COG0228	four-way junction DNA binding
G5V58_RS05845	COG1837	Belongs to the UPF0109 family
G5V58_RS05850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G5V58_RS05855	COG0336	Belongs to the RNA methyltransferase TrmD family
G5V58_RS05860	COG0335	large ribosomal subunit rRNA binding
G5V58_RS05865	COG0681	Belongs to the peptidase S26 family
G5V58_RS05870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G5V58_RS05895	COG4974	Belongs to the 'phage' integrase family
G5V58_RS05900	COG0758	DNA mediated transformation
G5V58_RS05910	COG0792	nuclease activity
G5V58_RS05930	COG0052	Belongs to the universal ribosomal protein uS2 family
G5V58_RS05935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G5V58_RS05940	COG0528	UMP kinase activity
G5V58_RS05945	COG0233	cytoplasmic translational termination
G5V58_RS05960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G5V58_RS06005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G5V58_RS06020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G5V58_RS06025	COG0010	Belongs to the arginase family
G5V58_RS06035	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS06075	COG0750	zinc metalloprotease
G5V58_RS06095	COG0693	protein deglycase activity
G5V58_RS06135	COG2197	response regulator
G5V58_RS06145	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS06165	COG4106	trans-aconitate 2-methyltransferase activity
G5V58_RS06175	COG0596	Alpha beta hydrolase
G5V58_RS06175	COG0508	dehydrogenase complex catalyzes the overall conversion of
G5V58_RS06210	COG0442	prolyl-tRNA aminoacylation
G5V58_RS06220	COG1309	transcriptional regulator
G5V58_RS06225	COG0596	Alpha beta hydrolase
G5V58_RS06230	COG0667	Aldo Keto reductase
G5V58_RS06250	COG0779	Required for maturation of 30S ribosomal subunits
G5V58_RS06290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G5V58_RS06295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G5V58_RS06300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G5V58_RS06305	COG0196	riboflavin kinase activity
G5V58_RS06310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G5V58_RS06310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G5V58_RS06310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G5V58_RS06325	COG2197	response regulator
G5V58_RS06345	COG1349	DNA-binding transcription factor activity
G5V58_RS06350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G5V58_RS06355	COG1063	alcohol dehydrogenase
G5V58_RS06365	COG0243	molybdopterin cofactor binding
G5V58_RS06380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G5V58_RS06385	COG1185	polyribonucleotide nucleotidyltransferase activity
G5V58_RS06390	COG0612	Peptidase, M16
G5V58_RS06395	COG5002	protein histidine kinase activity
G5V58_RS06405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G5V58_RS06410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G5V58_RS06420	COG1987	bacterial-type flagellum assembly
G5V58_RS06425	COG1338	Plays a role in the flagellum-specific transport system
G5V58_RS06435	COG1776	CheC inhibitor of MCP methylation
G5V58_RS06435	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5V58_RS06455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G5V58_RS06460	COG1582	Flagellar protein (FlbD)
G5V58_RS06480	COG1196	nuclear chromosome segregation
G5V58_RS06480	COG0739	heme binding
G5V58_RS06480	COG0741	lytic transglycosylase activity
G5V58_RS06500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5V58_RS06505	COG1766	The M ring may be actively involved in energy transduction
G5V58_RS06510	COG1677	Flagellar hook-basal body complex protein FliE
G5V58_RS06520	COG1815	bacterial-type flagellum-dependent cell motility
G5V58_RS06535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G5V58_RS06535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G5V58_RS06540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G5V58_RS06545	COG1191	sigma factor activity
G5V58_RS06555	COG1256	bacterial-type flagellum assembly
G5V58_RS06555	COG4786	Flagellar basal body rod
G5V58_RS06570	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G5V58_RS06590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G5V58_RS06650	COG0501	Belongs to the peptidase M48B family
G5V58_RS06660	COG2205	protein histidine kinase activity
G5V58_RS06675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G5V58_RS06695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G5V58_RS06705	COG1104	cysteine desulfurase activity
G5V58_RS06710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G5V58_RS06740	COG2205	protein histidine kinase activity
G5V58_RS06745	COG0745	RESPONSE REGULATOR receiver
G5V58_RS06765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G5V58_RS06770	COG0723	plastoquinol--plastocyanin reductase activity
G5V58_RS06775	COG2010	Cytochrome c
G5V58_RS06780	COG1845	cytochrome c oxidase, subunit III
G5V58_RS06795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G5V58_RS06825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G5V58_RS06855	COG0501	Belongs to the peptidase M48B family
G5V58_RS06870	COG2197	response regulator
G5V58_RS06875	COG4585	Histidine kinase
G5V58_RS06895	COG0489	protein tyrosine kinase activity
G5V58_RS06905	COG1022	Amp-dependent synthetase and ligase
G5V58_RS06915	COG0003	Pfam Anion-transporting ATPase
G5V58_RS06925	COG1940	carbohydrate kinase activity
G5V58_RS06930	COG1940	carbohydrate kinase activity
G5V58_RS06985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G5V58_RS07000	COG1113	amino acid transport
G5V58_RS07005	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G5V58_RS07030	COG2815	serine threonine protein kinase
G5V58_RS07030	COG0515	serine threonine protein kinase
G5V58_RS07050	COG0142	geranyltranstransferase activity
G5V58_RS07065	COG1233	COG1233 Phytoene dehydrogenase and related
G5V58_RS07085	COG1595	DNA-templated transcription, initiation
G5V58_RS07110	COG0587	DNA-directed DNA polymerase activity
G5V58_RS07120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G5V58_RS07140	COG0714	Associated with various cellular activities
G5V58_RS07145	COG2001	Belongs to the MraZ family
G5V58_RS07155	COG0275	rRNA processing
G5V58_RS07165	COG0768	penicillin binding
G5V58_RS07170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G5V58_RS07175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G5V58_RS07180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G5V58_RS07190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G5V58_RS07195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G5V58_RS07200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G5V58_RS07205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G5V58_RS07220	COG1799	cell septum assembly
G5V58_RS07240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G5V58_RS07255	COG0587	DNA-directed DNA polymerase activity
G5V58_RS07270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G5V58_RS07275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G5V58_RS07280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G5V58_RS07285	COG0131	Imidazoleglycerol-phosphate dehydratase
G5V58_RS07290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G5V58_RS07300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G5V58_RS07305	COG0107	imidazoleglycerol-phosphate synthase activity
G5V58_RS07320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G5V58_RS07335	COG1132	(ABC) transporter
G5V58_RS07345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G5V58_RS07370	COG0134	indole-3-glycerol-phosphate synthase activity
G5V58_RS07375	COG0133	tryptophan synthase activity
G5V58_RS07380	COG0159	tryptophan synthase activity
G5V58_RS07385	COG1999	signal sequence binding
G5V58_RS07390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G5V58_RS07395	COG0069	glutamate synthase activity
G5V58_RS07395	COG0067	glutamate synthase
G5V58_RS07395	COG0070	glutamate synthase
G5V58_RS07440	COG0410	ABC transporter
G5V58_RS07460	COG1811	Na channel or pump
G5V58_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS07505	COG0500	methyltransferase
G5V58_RS07510	COG4981	capsule polysaccharide biosynthetic process
G5V58_RS07540	COG2226	methyltransferase
G5V58_RS07550	COG0584	glycerophosphoryl diester phosphodiesterase
G5V58_RS07560	COG0539	negative regulation of cytoplasmic translation
G5V58_RS07585	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS07610	COG0237	dephospho-CoA kinase activity
G5V58_RS07630	COG4221	oxidoreductase activity
G5V58_RS07640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G5V58_RS07650	COG1984	allophanate hydrolase subunit 2
G5V58_RS07660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G5V58_RS07670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G5V58_RS07685	COG0589	response to stress
G5V58_RS07750	COG0187	DNA topoisomerase II activity
G5V58_RS07775	COG0477	Major facilitator Superfamily
G5V58_RS07785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G5V58_RS07805	COG0495	leucyl-tRNA aminoacylation
G5V58_RS07810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G5V58_RS07820	COG1307	EDD domain protein, DegV family
G5V58_RS07840	COG0268	Binds directly to 16S ribosomal RNA
G5V58_RS07860	COG4585	Histidine kinase
G5V58_RS07865	COG2197	response regulator
G5V58_RS07875	COG0481	GTPase activity
G5V58_RS07895	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS07905	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
G5V58_RS07910	COG2258	MOSC domain
G5V58_RS07945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G5V58_RS07955	COG1420	regulation of RNA biosynthetic process
G5V58_RS07960	COG0484	heat shock protein binding
G5V58_RS07985	COG0537	adenosine 5'-monophosphoramidase activity
G5V58_RS08010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G5V58_RS08035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G5V58_RS08045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G5V58_RS08060	COG0583	DNA-binding transcription factor activity
G5V58_RS08085	COG1914	H( )-stimulated, divalent metal cation uptake system
G5V58_RS08105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5V58_RS08120	COG0596	Alpha beta hydrolase
G5V58_RS08125	COG1381	Involved in DNA repair and RecF pathway recombination
G5V58_RS08130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G5V58_RS08135	COG5002	protein histidine kinase activity
G5V58_RS08145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G5V58_RS08150	COG1121	(ABC) transporter
G5V58_RS08155	COG0803	Belongs to the bacterial solute-binding protein 9 family
G5V58_RS08155	COG3443	Belongs to the bacterial solute-binding protein 9 family
G5V58_RS08165	COG0423	glycine-tRNA ligase activity
G5V58_RS08190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G5V58_RS08200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G5V58_RS08205	COG0358	DNA primase activity
G5V58_RS08230	COG0300	oxidoreductase activity
G5V58_RS08250	COG0515	serine threonine protein kinase
G5V58_RS08255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G5V58_RS08300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G5V58_RS08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G5V58_RS08310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G5V58_RS08335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G5V58_RS08345	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS08375	COG1063	alcohol dehydrogenase
G5V58_RS08410	COG0745	RESPONSE REGULATOR receiver
G5V58_RS08420	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS08465	COG3022	response to hydroperoxide
G5V58_RS08470	COG0557	exoribonuclease II activity
G5V58_RS08485	COG2080	2 iron, 2 sulfur cluster binding
G5V58_RS08490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G5V58_RS08495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G5V58_RS08540	COG1921	L-seryl-tRNASec selenium transferase activity
G5V58_RS08560	COG0243	molybdopterin cofactor binding
G5V58_RS08560	COG3383	formate dehydrogenase (NAD+) activity
G5V58_RS08565	COG0437	4 iron, 4 sulfur cluster binding
G5V58_RS08575	COG0709	Synthesizes selenophosphate from selenide and ATP
G5V58_RS08595	COG0765	amino acid transport
G5V58_RS08600	COG1126	abc transporter atp-binding protein
G5V58_RS08605	COG4221	oxidoreductase activity
G5V58_RS08635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G5V58_RS08695	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS08700	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS08740	COG1305	Transglutaminase-like
G5V58_RS08775	COG4585	Histidine kinase
G5V58_RS08785	COG1131	(ABC) transporter
G5V58_RS08795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G5V58_RS08825	COG1435	thymidine kinase activity
G5V58_RS08845	COG2130	NADP-dependent
G5V58_RS08850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G5V58_RS08885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G5V58_RS08910	COG0756	dUTP diphosphatase activity
G5V58_RS08935	COG0569	domain protein
G5V58_RS08940	COG0531	amino acid
G5V58_RS08945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G5V58_RS08950	COG3340	Belongs to the peptidase S51 family
G5V58_RS08960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G5V58_RS08985	COG1595	DNA-templated transcription, initiation
G5V58_RS09030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G5V58_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS09075	COG0667	Aldo Keto reductase
G5V58_RS09115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G5V58_RS09130	COG1946	Acyl-CoA thioesterase
G5V58_RS09165	COG2030	dehydratase
G5V58_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS09175	COG0183	Belongs to the thiolase family
G5V58_RS09195	COG1793	dna ligase
G5V58_RS09200	COG3795	YCII-related domain
G5V58_RS09205	COG4941	Belongs to the sigma-70 factor family
G5V58_RS09275	COG0730	response to heat
G5V58_RS09285	COG1024	Enoyl-CoA hydratase
G5V58_RS09295	COG3795	YCII-related domain
G5V58_RS09300	COG4941	Belongs to the sigma-70 factor family
G5V58_RS09325	COG2205	protein histidine kinase activity
G5V58_RS09330	COG0745	RESPONSE REGULATOR receiver
G5V58_RS09340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G5V58_RS09340	COG1017	nitric oxide dioxygenase activity
G5V58_RS09370	COG0444	Belongs to the ABC transporter superfamily
G5V58_RS09395	COG4948	Mandelate Racemase Muconate Lactonizing
G5V58_RS09400	COG2508	Transcriptional regulator
G5V58_RS09400	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G5V58_RS09405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G5V58_RS09420	COG0556	nucleotide-excision repair
G5V58_RS09430	COG0667	Aldo Keto reductase
G5V58_RS09440	COG2986	histidine ammonia-lyase
G5V58_RS09460	COG3180	Ammonia monooxygenase
G5V58_RS09475	COG0784	Response regulator, receiver
G5V58_RS09475	COG2205	protein histidine kinase activity
G5V58_RS09475	COG5002	protein histidine kinase activity
G5V58_RS09495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G5V58_RS09515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G5V58_RS09545	COG0492	ferredoxin-NADP+ reductase activity
G5V58_RS09555	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS09585	COG1309	transcriptional regulator
G5V58_RS09610	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09615	COG0657	acetylesterase activity
G5V58_RS09645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G5V58_RS09655	COG2149	membrane
G5V58_RS09660	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09675	COG0183	Belongs to the thiolase family
G5V58_RS09685	COG0789	Transcriptional regulator
G5V58_RS09695	COG3046	protein related to deoxyribodipyrimidine photolyase
G5V58_RS09705	COG1216	Glycosyl transferase, family 2
G5V58_RS09710	COG3132	Protein of unknown function, DUF480
G5V58_RS09720	COG2267	carboxylic ester hydrolase activity
G5V58_RS09725	COG2030	dehydratase
G5V58_RS09730	COG1053	succinate dehydrogenase
G5V58_RS09735	COG3971	2-oxopent-4-enoate hydratase activity
G5V58_RS09740	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G5V58_RS09745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5V58_RS09755	COG2318	DinB family
G5V58_RS09760	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09765	COG2267	carboxylic ester hydrolase activity
G5V58_RS09770	COG0346	lactoylglutathione lyase activity
G5V58_RS09775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G5V58_RS09795	COG2409	Drug exporters of the RND superfamily
G5V58_RS09805	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09810	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09815	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09820	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS09825	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS09835	COG1309	transcriptional regulator
G5V58_RS09840	COG0183	Belongs to the thiolase family
G5V58_RS09855	COG0656	L-ascorbic acid biosynthetic process
G5V58_RS09860	COG2814	Major facilitator Superfamily
G5V58_RS09870	COG0456	acetyltransferase
G5V58_RS09870	COG0454	-acetyltransferase
G5V58_RS09890	COG1024	Enoyl-CoA hydratase
G5V58_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS09910	COG0183	Belongs to the thiolase family
G5V58_RS09915	COG2124	cytochrome p450
G5V58_RS09920	COG2124	cytochrome p450
G5V58_RS09935	COG0740	serine-type endopeptidase activity
G5V58_RS09940	COG0740	serine-type endopeptidase activity
G5V58_RS09955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G5V58_RS09995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS10005	COG3618	amidohydrolase
G5V58_RS10030	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS10045	COG1024	Enoyl-CoA hydratase
G5V58_RS10055	COG2070	2-Nitropropane dioxygenase
G5V58_RS10060	COG0596	Alpha beta hydrolase
G5V58_RS10090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G5V58_RS10100	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS10105	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS10110	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS10150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G5V58_RS10165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G5V58_RS10185	COG0322	excinuclease ABC activity
G5V58_RS10190	COG1660	Displays ATPase and GTPase activities
G5V58_RS10200	COG1481	regulation of sporulation
G5V58_RS10205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G5V58_RS10210	COG0126	phosphoglycerate kinase activity
G5V58_RS10215	COG0149	triose-phosphate isomerase activity
G5V58_RS10220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G5V58_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS10245	COG0583	DNA-binding transcription factor activity
G5V58_RS10255	COG0363	glucosamine-6-phosphate deaminase activity
G5V58_RS10270	COG0166	Belongs to the GPI family
G5V58_RS10275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G5V58_RS10285	COG0109	protoheme IX farnesyltransferase activity
G5V58_RS10295	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS10325	COG1414	Transcriptional regulator
G5V58_RS10340	COG1131	(ABC) transporter
G5V58_RS10370	COG2146	nitrite reductase [NAD(P)H] activity
G5V58_RS10375	COG0396	ATPase activity
G5V58_RS10380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G5V58_RS10385	COG0822	iron-sulfur transferase activity
G5V58_RS10390	COG2151	metal-sulfur cluster biosynthetic enzyme
G5V58_RS10415	COG0346	lactoylglutathione lyase activity
G5V58_RS10440	COG0488	(ABC) transporter
G5V58_RS10445	COG1024	Enoyl-CoA hydratase
G5V58_RS10445	COG1250	3-hydroxyacyl-CoA dehydrogenase
G5V58_RS10450	COG1132	(ABC) transporter
G5V58_RS10465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G5V58_RS10480	COG3360	Dodecin
G5V58_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS10495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G5V58_RS10495	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS10500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G5V58_RS10500	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS10505	COG4242	Belongs to the peptidase S51 family
G5V58_RS10520	COG0560	Phosphoserine phosphatase
G5V58_RS10520	COG3830	Belongs to the UPF0237 family
G5V58_RS10540	COG1119	ATPase activity
G5V58_RS10570	COG0483	inositol monophosphate 1-phosphatase activity
G5V58_RS10595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G5V58_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS10605	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS10670	COG1881	PFAM PEBP family protein
G5V58_RS10675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G5V58_RS10675	COG1648	precorrin-2 dehydrogenase activity
G5V58_RS10685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G5V58_RS10690	COG0242	peptide deformylase activity
G5V58_RS10700	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS10715	COG3979	chitinase
G5V58_RS10735	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G5V58_RS10745	COG0583	DNA-binding transcription factor activity
G5V58_RS10750	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G5V58_RS10770	COG0587	DNA-directed DNA polymerase activity
G5V58_RS10775	COG2814	Major facilitator Superfamily
G5V58_RS10790	COG0252	asparaginase activity
G5V58_RS10795	COG0604	alcohol dehydrogenase
G5V58_RS10795	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS10795	COG3321	synthase
G5V58_RS10805	COG1116	anion transmembrane transporter activity
G5V58_RS10810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G5V58_RS10815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G5V58_RS10815	COG1116	anion transmembrane transporter activity
G5V58_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS10845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5V58_RS10855	COG0667	Aldo Keto reductase
G5V58_RS10860	COG1968	undecaprenyl-diphosphatase activity
G5V58_RS10865	COG0598	Magnesium transport protein CorA
G5V58_RS10885	COG0215	cysteine-tRNA ligase activity
G5V58_RS10900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G5V58_RS10915	COG0517	IMP dehydrogenase activity
G5V58_RS10915	COG1994	Peptidase M50
G5V58_RS10925	COG1222	aaa ATPase
G5V58_RS10950	COG2226	methyltransferase
G5V58_RS10955	COG4122	O-methyltransferase activity
G5V58_RS10965	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G5V58_RS10970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G5V58_RS10975	COG1051	belongs to the nudix hydrolase family
G5V58_RS10980	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G5V58_RS10985	COG0545	Peptidyl-prolyl cis-trans isomerase
G5V58_RS11005	COG0805	protein transport
G5V58_RS11015	COG2200	EAL domain
G5V58_RS11030	COG0829	nickel cation binding
G5V58_RS11035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G5V58_RS11045	COG0804	urea catabolic process
G5V58_RS11050	COG0831	urea catabolic process
G5V58_RS11050	COG0832	Belongs to the urease beta subunit family
G5V58_RS11055	COG0702	epimerase
G5V58_RS11060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G5V58_RS11080	COG0604	alcohol dehydrogenase
G5V58_RS11085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G5V58_RS11090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G5V58_RS11095	COG1607	acyl-coa hydrolase
G5V58_RS11105	COG1216	Glycosyl transferase, family 2
G5V58_RS11110	COG3030	protein affecting phage T7 exclusion by the F plasmid
G5V58_RS11140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G5V58_RS11170	COG1846	Transcriptional regulator
G5V58_RS11185	COG0346	lactoylglutathione lyase activity
G5V58_RS11195	COG1316	TRANSCRIPTIONal
G5V58_RS11230	COG2119	membrane
G5V58_RS11255	COG1132	(ABC) transporter
G5V58_RS11270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS11285	COG1357	PFAM Pentapeptide repeats (8 copies)
G5V58_RS11320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G5V58_RS11345	COG0420	3'-5' exonuclease activity
G5V58_RS11350	COG0419	ATPase involved in DNA repair
G5V58_RS11355	COG4106	trans-aconitate 2-methyltransferase activity
G5V58_RS11400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G5V58_RS11400	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G5V58_RS11420	COG1716	ATPase activity
G5V58_RS11485	COG0737	Belongs to the 5'-nucleotidase family
G5V58_RS11485	COG4085	toxin activity
G5V58_RS11485	COG1525	nuclease
G5V58_RS11495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G5V58_RS11500	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G5V58_RS11505	COG1120	ATPase activity
G5V58_RS11510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G5V58_RS11520	COG0110	maltose O-acetyltransferase activity
G5V58_RS11530	COG1366	Belongs to the anti-sigma-factor antagonist family
G5V58_RS11580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G5V58_RS11585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G5V58_RS11600	COG3485	protocatechuate 3,4-dioxygenase
G5V58_RS11650	COG0395	ABC-type sugar transport system, permease component
G5V58_RS11655	COG1175	transmembrane transport
G5V58_RS11665	COG2207	Transcriptional regulator
G5V58_RS11670	COG1609	Transcriptional regulator
G5V58_RS11680	COG1063	alcohol dehydrogenase
G5V58_RS11700	COG0673	inositol 2-dehydrogenase activity
G5V58_RS11705	COG0673	inositol 2-dehydrogenase activity
G5V58_RS11735	COG0667	Aldo Keto reductase
G5V58_RS11740	COG1063	alcohol dehydrogenase
G5V58_RS11760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G5V58_RS11865	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS11900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G5V58_RS11905	COG1414	Transcriptional regulator
G5V58_RS11915	COG1175	transmembrane transport
G5V58_RS11920	COG0395	ABC-type sugar transport system, permease component
G5V58_RS11940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G5V58_RS11945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G5V58_RS12020	COG1160	GTP binding
G5V58_RS12030	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G5V58_RS12060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G5V58_RS12065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G5V58_RS12100	COG0686	Belongs to the AlaDH PNT family
G5V58_RS12105	COG0494	nUDIX hydrolase
G5V58_RS12115	COG0504	CTP synthase activity
G5V58_RS12130	COG0497	DNA recombination
G5V58_RS12135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G5V58_RS12150	COG0647	UMP catabolic process
G5V58_RS12180	COG2094	Belongs to the DNA glycosylase MPG family
G5V58_RS12185	COG0165	Argininosuccinate lyase
G5V58_RS12195	COG0137	argininosuccinate synthase activity
G5V58_RS12200	COG1438	arginine binding
G5V58_RS12205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G5V58_RS12210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G5V58_RS12215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G5V58_RS12220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G5V58_RS12230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G5V58_RS12240	COG2318	DinB family
G5V58_RS12245	COG0667	Aldo Keto reductase
G5V58_RS12275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G5V58_RS12280	COG2205	protein histidine kinase activity
G5V58_RS12285	COG0745	RESPONSE REGULATOR receiver
G5V58_RS12290	COG5002	protein histidine kinase activity
G5V58_RS12305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G5V58_RS12310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G5V58_RS12315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G5V58_RS12320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G5V58_RS12330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G5V58_RS12335	COG1116	anion transmembrane transporter activity
G5V58_RS12340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G5V58_RS12345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS12360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G5V58_RS12365	COG2017	converts alpha-aldose to the beta-anomer
G5V58_RS12375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G5V58_RS12380	COG0140	phosphoribosyl-ATP diphosphatase activity
G5V58_RS12385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G5V58_RS12390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G5V58_RS12390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G5V58_RS12395	COG3201	nicotinamide mononucleotide transporter
G5V58_RS12415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G5V58_RS12420	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS12455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G5V58_RS12460	COG0242	peptide deformylase activity
G5V58_RS12465	COG4221	oxidoreductase activity
G5V58_RS12490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G5V58_RS12500	COG1758	RNA polymerase activity
G5V58_RS12505	COG0194	GDP metabolic process
G5V58_RS12520	COG0284	orotidine-5'-phosphate decarboxylase activity
G5V58_RS12525	COG0167	dihydroorotate dehydrogenase activity
G5V58_RS12530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G5V58_RS12535	COG0505	Belongs to the CarA family
G5V58_RS12540	COG2267	carboxylic ester hydrolase activity
G5V58_RS12545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G5V58_RS12550	COG0540	Belongs to the ATCase OTCase family
G5V58_RS12555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G5V58_RS12560	COG3804	dihydrodipicolinate reductase
G5V58_RS12580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G5V58_RS12600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G5V58_RS12605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G5V58_RS12615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G5V58_RS12620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G5V58_RS12625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G5V58_RS12630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G5V58_RS12640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G5V58_RS12650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G5V58_RS12655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G5V58_RS12675	COG4608	Belongs to the ABC transporter superfamily
G5V58_RS12680	COG0444	Belongs to the ABC transporter superfamily
G5V58_RS12685	COG0601	transmembrane transport
G5V58_RS12695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G5V58_RS12700	COG4608	Belongs to the ABC transporter superfamily
G5V58_RS12710	COG0601	transmembrane transport
G5V58_RS12715	COG4166	transmembrane transport
G5V58_RS12720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G5V58_RS12725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G5V58_RS12730	COG0124	histidyl-tRNA synthetase
G5V58_RS12740	COG1196	nuclear chromosome segregation
G5V58_RS12745	COG4565	transcriptional regulatory protein
G5V58_RS12750	COG3290	protein histidine kinase activity
G5V58_RS12770	COG0589	response to stress
G5V58_RS12785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G5V58_RS12790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G5V58_RS12795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G5V58_RS12800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G5V58_RS12810	COG2255	four-way junction helicase activity
G5V58_RS12815	COG0632	four-way junction helicase activity
G5V58_RS12820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G5V58_RS12840	COG0217	transcriptional regulatory protein
G5V58_RS12845	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G5V58_RS12865	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G5V58_RS12870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G5V58_RS12910	COG2226	methyltransferase
G5V58_RS12915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G5V58_RS12975	COG1216	Glycosyl transferase, family 2
G5V58_RS13000	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS13005	COG1301	dicarboxylic acid transport
G5V58_RS13010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G5V58_RS13015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G5V58_RS13025	COG0175	sulfate reduction
G5V58_RS13050	COG2326	polyphosphate kinase activity
G5V58_RS13070	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G5V58_RS13080	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G5V58_RS13125	COG0402	S-adenosylhomocysteine deaminase activity
G5V58_RS13135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G5V58_RS13145	COG3257	ureidoglycine aminohydrolase activity
G5V58_RS13150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G5V58_RS13155	COG2351	hydroxyisourate hydrolase activity
G5V58_RS13180	COG1201	RNA secondary structure unwinding
G5V58_RS13185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G5V58_RS13200	COG1546	Belongs to the CinA family
G5V58_RS13200	COG1058	Belongs to the CinA family
G5V58_RS13215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G5V58_RS13225	COG1674	ftsk spoiiie
G5V58_RS13230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G5V58_RS13250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G5V58_RS13255	COG0384	phenazine biosynthesis protein PhzF
G5V58_RS13275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G5V58_RS13280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G5V58_RS13290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G5V58_RS13325	COG0640	Transcriptional regulator
G5V58_RS13330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G5V58_RS13355	COG1366	Belongs to the anti-sigma-factor antagonist family
G5V58_RS13360	COG2202	Pas domain
G5V58_RS13360	COG3920	Histidine kinase
G5V58_RS13390	COG1492	cobalamin metabolic process
G5V58_RS13410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G5V58_RS13415	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G5V58_RS13470	COG0588	phosphoglycerate mutase activity
G5V58_RS13485	COG0640	Transcriptional regulator
G5V58_RS13505	COG0463	Glycosyl transferase, family 2
G5V58_RS13510	COG0672	)-iron permease
G5V58_RS13520	COG2205	protein histidine kinase activity
G5V58_RS13525	COG0745	RESPONSE REGULATOR receiver
G5V58_RS13535	COG0586	Pfam SNARE associated Golgi protein
G5V58_RS13545	COG0726	polysaccharide deacetylase
G5V58_RS13555	COG0745	RESPONSE REGULATOR receiver
G5V58_RS13565	COG1968	undecaprenyl-diphosphatase activity
G5V58_RS13580	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS13585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G5V58_RS13590	COG0463	Glycosyl transferase, family 2
G5V58_RS13600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G5V58_RS13605	COG0671	phosphoesterase, PA-phosphatase related
G5V58_RS13620	COG1131	(ABC) transporter
G5V58_RS13630	COG0174	glutamine synthetase
G5V58_RS13645	COG1280	lysine exporter protein (LysE YggA)
G5V58_RS13660	COG5002	protein histidine kinase activity
G5V58_RS13665	COG2264	protein methyltransferase activity
G5V58_RS13670	COG5001	Diguanylate cyclase
G5V58_RS13670	COG3300	MHYT domain
G5V58_RS13675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G5V58_RS13680	COG1017	nitric oxide dioxygenase activity
G5V58_RS13680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G5V58_RS13695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G5V58_RS13705	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G5V58_RS13725	COG1131	(ABC) transporter
G5V58_RS13740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS13750	COG0431	NADPH-dependent FMN reductase
G5V58_RS13765	COG0789	Transcriptional regulator
G5V58_RS13790	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G5V58_RS13810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G5V58_RS13825	COG0174	glutamine synthetase
G5V58_RS13855	COG0463	Glycosyl transferase, family 2
G5V58_RS13860	COG2124	cytochrome p450
G5V58_RS13875	COG0667	Aldo Keto reductase
G5V58_RS13885	COG0745	RESPONSE REGULATOR receiver
G5V58_RS13910	COG2072	flavoprotein involved in K transport
G5V58_RS13925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G5V58_RS13945	COG2318	DinB family
G5V58_RS13950	COG5002	protein histidine kinase activity
G5V58_RS13960	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS13970	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS13975	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS13980	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5V58_RS14015	COG1129	ABC transporter
G5V58_RS14020	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS14035	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS14040	COG1024	Enoyl-CoA hydratase
G5V58_RS14055	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS14060	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS14080	COG1802	Transcriptional regulator
G5V58_RS14085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G5V58_RS14100	COG1832	CoA-binding protein
G5V58_RS14110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G5V58_RS14165	COG0799	negative regulation of ribosome biogenesis
G5V58_RS14170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G5V58_RS14180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G5V58_RS14215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G5V58_RS14245	COG0706	membrane insertase activity
G5V58_RS14260	COG0058	SHG alpha-glucan phosphorylase activity
G5V58_RS14265	COG0366	Alpha amylase catalytic
G5V58_RS14280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G5V58_RS14320	COG4978	Transcriptional regulator
G5V58_RS14320	COG0789	Transcriptional regulator
G5V58_RS14325	COG0477	Major facilitator Superfamily
G5V58_RS14335	COG0183	Belongs to the thiolase family
G5V58_RS14355	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS14405	COG1902	pentaerythritol trinitrate reductase activity
G5V58_RS14410	COG0596	Alpha beta hydrolase
G5V58_RS14430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS14435	COG0667	Aldo Keto reductase
G5V58_RS14440	COG0477	Major facilitator Superfamily
G5V58_RS14460	COG1250	3-hydroxyacyl-CoA dehydrogenase
G5V58_RS14475	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
G5V58_RS14490	COG3119	arylsulfatase activity
G5V58_RS14500	COG1528	Iron-storage protein
G5V58_RS14510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G5V58_RS14510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G5V58_RS14535	COG0738	Major facilitator superfamily
G5V58_RS14545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G5V58_RS14550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G5V58_RS14555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G5V58_RS14560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G5V58_RS14565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G5V58_RS14570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G5V58_RS14575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G5V58_RS14580	COG0356	it plays a direct role in the translocation of protons across the membrane
G5V58_RS14595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G5V58_RS14600	COG0009	L-threonylcarbamoyladenylate synthase
G5V58_RS14605	COG2890	protein-(glutamine-N5) methyltransferase activity
G5V58_RS14610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G5V58_RS14615	COG0254	rRNA binding
G5V58_RS14620	COG0745	RESPONSE REGULATOR receiver
G5V58_RS14630	COG0083	homoserine kinase activity
G5V58_RS14635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G5V58_RS14640	COG0460	homoserine dehydrogenase
G5V58_RS14650	COG0018	arginyl-trna synthetase
G5V58_RS14695	COG2755	lipolytic protein G-D-S-L family
G5V58_RS14695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G5V58_RS14700	COG2755	lipolytic protein G-D-S-L family
G5V58_RS14700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G5V58_RS14715	COG1309	transcriptional regulator
G5V58_RS14720	COG1316	TRANSCRIPTIONal
G5V58_RS14730	COG0567	Dehydrogenase, E1 component
G5V58_RS14730	COG0508	dehydrogenase complex catalyzes the overall conversion of
G5V58_RS14795	COG0604	alcohol dehydrogenase
G5V58_RS14830	COG1191	sigma factor activity
G5V58_RS14875	COG1595	DNA-templated transcription, initiation
G5V58_RS14885	COG2135	peptidase activity
G5V58_RS14900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G5V58_RS14905	COG1162	GTPase activity
G5V58_RS14915	COG0483	inositol monophosphate 1-phosphatase activity
G5V58_RS14920	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G5V58_RS14930	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS14945	COG2501	S4 domain
G5V58_RS14950	COG2733	membrane
G5V58_RS14955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G5V58_RS14960	COG0531	amino acid
G5V58_RS15000	COG2018	Roadblock/LC7 domain
G5V58_RS15010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS15035	COG2050	protein possibly involved in aromatic compounds catabolism
G5V58_RS15050	COG4221	oxidoreductase activity
G5V58_RS15055	COG1280	lysine exporter protein (LysE YggA)
G5V58_RS15065	COG2267	carboxylic ester hydrolase activity
G5V58_RS15070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G5V58_RS15090	COG2860	membrane
G5V58_RS15100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS15115	COG1615	UPF0182 protein
G5V58_RS15125	COG3480	Lon protease (S16) C-terminal proteolytic domain
G5V58_RS15155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G5V58_RS15155	COG1796	DNA polymerase
G5V58_RS15160	COG1024	Enoyl-CoA hydratase
G5V58_RS15205	COG2816	NAD+ diphosphatase activity
G5V58_RS15270	COG0714	Associated with various cellular activities
G5V58_RS15300	COG0549	Belongs to the carbamate kinase family
G5V58_RS15305	COG5002	protein histidine kinase activity
G5V58_RS15310	COG0745	RESPONSE REGULATOR receiver
G5V58_RS15350	COG0604	alcohol dehydrogenase
G5V58_RS15390	COG2233	PERMEase
G5V58_RS15400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G5V58_RS15405	COG1304	FMN binding
G5V58_RS15420	COG1309	transcriptional regulator
G5V58_RS15440	COG0513	Belongs to the DEAD box helicase family
G5V58_RS15445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G5V58_RS15455	COG1192	Involved in chromosome partitioning
G5V58_RS15460	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS15470	COG0613	PHP domain protein
G5V58_RS15480	COG0406	alpha-ribazole phosphatase activity
G5V58_RS15500	COG3104	oligopeptide transport
G5V58_RS15600	COG2239	Acts as a magnesium transporter
G5V58_RS15615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G5V58_RS15640	COG1136	(ABC) transporter
G5V58_RS15645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G5V58_RS15655	COG0653	protein targeting
G5V58_RS15660	COG1309	transcriptional regulator
G5V58_RS15665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G5V58_RS15675	COG2197	response regulator
G5V58_RS15680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G5V58_RS15685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G5V58_RS15690	COG5401	PFAM Sporulation and spore germination
G5V58_RS15695	COG5002	protein histidine kinase activity
G5V58_RS15695	COG5000	phosphorelay sensor kinase activity
G5V58_RS15700	COG0745	RESPONSE REGULATOR receiver
G5V58_RS15705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G5V58_RS15710	COG2354	Protein conserved in bacteria
G5V58_RS15725	COG2835	tetraacyldisaccharide 4'-kinase activity
G5V58_RS15745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G5V58_RS15765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G5V58_RS15770	COG0778	Nitroreductase
G5V58_RS15770	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G5V58_RS15780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G5V58_RS15780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G5V58_RS15800	COG0545	Peptidyl-prolyl cis-trans isomerase
G5V58_RS15810	COG1819	glycosyl
G5V58_RS15815	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS15835	COG1216	Glycosyl transferase, family 2
G5V58_RS15855	COG1216	Glycosyl transferase, family 2
G5V58_RS15860	COG1216	Glycosyl transferase, family 2
G5V58_RS15870	COG1316	TRANSCRIPTIONal
G5V58_RS15885	COG1316	TRANSCRIPTIONal
G5V58_RS15890	COG1024	Enoyl-CoA hydratase
G5V58_RS15895	COG1136	(ABC) transporter
G5V58_RS15900	COG0783	Belongs to the Dps family
G5V58_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS15915	COG1366	Belongs to the anti-sigma-factor antagonist family
G5V58_RS15920	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS15935	COG2197	response regulator
G5V58_RS15955	COG2205	protein histidine kinase activity
G5V58_RS15975	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G5V58_RS15990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G5V58_RS16010	COG0424	maF-like protein
G5V58_RS16025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G5V58_RS16030	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS16035	COG4770	biotin carboxylase activity
G5V58_RS16040	COG3135	benzoate transporter
G5V58_RS16080	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G5V58_RS16090	COG2385	sporulation resulting in formation of a cellular spore
G5V58_RS16105	COG2197	response regulator
G5V58_RS16140	COG0789	Transcriptional regulator
G5V58_RS16145	COG0667	Aldo Keto reductase
G5V58_RS16150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5V58_RS16160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G5V58_RS16170	COG1309	transcriptional regulator
G5V58_RS16185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G5V58_RS16190	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS16225	COG2197	response regulator
G5V58_RS16230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G5V58_RS16260	COG1079	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS16265	COG4603	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS16270	COG3845	ABC transporter
G5V58_RS16275	COG1744	ABC transporter substrate-binding protein PnrA-like
G5V58_RS16280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G5V58_RS16280	COG1473	amidohydrolase
G5V58_RS16330	COG1053	succinate dehydrogenase
G5V58_RS16345	COG1053	succinate dehydrogenase
G5V58_RS16350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G5V58_RS16385	COG0596	Alpha beta hydrolase
G5V58_RS16400	COG0180	Tryptophanyl-tRNA synthetase
G5V58_RS16405	COG5002	protein histidine kinase activity
G5V58_RS16415	COG2814	Major facilitator Superfamily
G5V58_RS16425	COG2838	Isocitrate dehydrogenase
G5V58_RS16430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G5V58_RS16440	COG0039	L-malate dehydrogenase activity
G5V58_RS16450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G5V58_RS16455	COG0138	bifunctional purine biosynthesis protein purh
G5V58_RS16495	COG0045	succinate-CoA ligase (ADP-forming) activity
G5V58_RS16510	COG0395	ABC-type sugar transport system, permease component
G5V58_RS16530	COG1733	regulation of RNA biosynthetic process
G5V58_RS16565	COG0582	viral genome integration into host DNA
G5V58_RS16605	COG2197	response regulator
G5V58_RS16655	COG1132	(ABC) transporter
G5V58_RS16660	COG2197	response regulator
G5V58_RS16670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G5V58_RS16670	COG2755	lipolytic protein G-D-S-L family
G5V58_RS16675	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS16685	COG2197	response regulator
G5V58_RS16695	COG0745	RESPONSE REGULATOR receiver
G5V58_RS16705	COG3285	dna ligase
G5V58_RS16705	COG1793	dna ligase
G5V58_RS16710	COG3285	dna ligase
G5V58_RS16710	COG1793	dna ligase
G5V58_RS16715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G5V58_RS16730	COG0142	geranyltranstransferase activity
G5V58_RS16755	COG0596	Alpha beta hydrolase
G5V58_RS16765	COG1132	(ABC) transporter
G5V58_RS16770	COG1132	(ABC) transporter
G5V58_RS16780	COG2902	Dehydrogenase
G5V58_RS16785	COG1522	sequence-specific DNA binding
G5V58_RS16795	COG3483	tryptophan 2,3-dioxygenase activity
G5V58_RS16830	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS16865	COG1910	domain protein
G5V58_RS16875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5V58_RS16900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G5V58_RS16910	COG1024	Enoyl-CoA hydratase
G5V58_RS16955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5V58_RS16970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G5V58_RS16985	COG2318	DinB family
G5V58_RS16995	COG3214	Protein conserved in bacteria
G5V58_RS17005	COG2171	N-acyltransferase activity
G5V58_RS17025	COG3706	GGDEF domain
G5V58_RS17045	COG0017	Asparaginyl-tRNA synthetase
G5V58_RS17065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G5V58_RS17070	COG0494	nUDIX hydrolase
G5V58_RS17100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G5V58_RS17175	COG0012	GTP binding
G5V58_RS17195	COG1183	phosphatidylcholine synthase activity
G5V58_RS17200	COG0708	Exodeoxyribonuclease III
G5V58_RS17220	COG1322	Protein conserved in bacteria
G5V58_RS17235	COG0009	L-threonylcarbamoyladenylate synthase
G5V58_RS17250	COG1570	exodeoxyribonuclease VII activity
G5V58_RS17255	COG1722	exodeoxyribonuclease VII activity
G5V58_RS17265	COG3540	Alkaline phosphatase
G5V58_RS17275	COG2319	Wd-40 repeat
G5V58_RS17275	COG4249	Peptidase C14 caspase catalytic subunit p20
G5V58_RS17280	COG0471	metal ion transport
G5V58_RS17280	COG0490	domain, Protein
G5V58_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS17380	COG0114	fumarate hydratase activity
G5V58_RS17385	COG2226	methyltransferase
G5V58_RS17400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G5V58_RS17405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G5V58_RS17415	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS17430	COG1331	Highly conserved protein containing a thioredoxin domain
G5V58_RS17475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G5V58_RS17480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G5V58_RS17490	COG2072	flavoprotein involved in K transport
G5V58_RS17510	COG0596	Alpha beta hydrolase
G5V58_RS17525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G5V58_RS17535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G5V58_RS17545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G5V58_RS17575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G5V58_RS17600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G5V58_RS17630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G5V58_RS17655	COG1247	-acetyltransferase
G5V58_RS17660	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G5V58_RS17670	COG3012	SEC-C Motif Domain Protein
G5V58_RS17695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G5V58_RS17715	COG2318	DinB family
G5V58_RS17735	COG2197	response regulator
G5V58_RS17790	COG0148	phosphopyruvate hydratase activity
G5V58_RS17835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G5V58_RS17895	COG3291	Pkd domain containing protein
G5V58_RS17900	COG0730	response to heat
G5V58_RS17915	COG5002	protein histidine kinase activity
G5V58_RS17930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G5V58_RS17940	COG1218	3'(2'),5'-bisphosphate nucleotidase
G5V58_RS17945	COG3852	Histidine kinase
G5V58_RS17955	COG0193	aminoacyl-tRNA hydrolase activity
G5V58_RS17970	COG0778	Nitroreductase
G5V58_RS17990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G5V58_RS17995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G5V58_RS18025	COG1793	dna ligase
G5V58_RS18040	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS18045	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS18070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G5V58_RS18085	COG0747	negative chemotaxis
G5V58_RS18090	COG0601	transmembrane transport
G5V58_RS18105	COG4608	Belongs to the ABC transporter superfamily
G5V58_RS18110	COG4638	Rieske (2fe-2S)
G5V58_RS18125	COG4638	Rieske (2fe-2S)
G5V58_RS18170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G5V58_RS18180	COG3631	Ketosteroid isomerase-related protein
G5V58_RS18190	COG1902	pentaerythritol trinitrate reductase activity
G5V58_RS18220	COG2197	response regulator
G5V58_RS18225	COG2188	Transcriptional regulator
G5V58_RS18230	COG0577	efflux transmembrane transporter activity
G5V58_RS18230	COG1136	(ABC) transporter
G5V58_RS18235	COG1136	(ABC) transporter
G5V58_RS18235	COG0577	efflux transmembrane transporter activity
G5V58_RS18250	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G5V58_RS18255	COG0667	Aldo Keto reductase
G5V58_RS18265	COG1704	LemA family
G5V58_RS18310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G5V58_RS18355	COG1401	restriction endodeoxyribonuclease activity
G5V58_RS18380	COG1111	helicase
G5V58_RS18380	COG1205	dead DEAH box helicase
G5V58_RS18400	COG0789	Transcriptional regulator
G5V58_RS18430	COG3621	Patatin-like phospholipase
G5V58_RS18435	COG0346	lactoylglutathione lyase activity
G5V58_RS18465	COG0459	protein refolding
G5V58_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS18485	COG2723	6-phospho-beta-galactosidase activity
G5V58_RS18490	COG0395	ABC-type sugar transport system, permease component
G5V58_RS18510	COG1595	DNA-templated transcription, initiation
G5V58_RS18515	COG0531	amino acid
G5V58_RS18525	COG3795	YCII-related domain
G5V58_RS18530	COG3795	YCII-related domain
G5V58_RS18535	COG3795	YCII-related domain
G5V58_RS18540	COG4941	Belongs to the sigma-70 factor family
G5V58_RS18555	COG2755	lipolytic protein G-D-S-L family
G5V58_RS18595	COG0673	inositol 2-dehydrogenase activity
G5V58_RS18615	COG4585	Histidine kinase
G5V58_RS18620	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G5V58_RS18655	COG1063	alcohol dehydrogenase
G5V58_RS18665	COG0235	Class ii aldolase
G5V58_RS18675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G5V58_RS18680	COG3384	dioxygenase
G5V58_RS18685	COG0784	Response regulator, receiver
G5V58_RS18685	COG2205	protein histidine kinase activity
G5V58_RS18690	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS18695	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G5V58_RS18700	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G5V58_RS18705	COG2860	membrane
G5V58_RS18730	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS18785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G5V58_RS18790	COG0215	cysteine-tRNA ligase activity
G5V58_RS18805	COG0784	Response regulator, receiver
G5V58_RS18810	COG4251	negative regulation of phosphorylation
G5V58_RS18840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G5V58_RS18855	COG3227	Zinc metalloprotease (Elastase)
G5V58_RS18895	COG1329	Transcriptional regulator
G5V58_RS18910	COG0588	phosphoglycerate mutase activity
G5V58_RS18920	COG5002	protein histidine kinase activity
G5V58_RS18925	COG0745	RESPONSE REGULATOR receiver
G5V58_RS18930	COG1309	transcriptional regulator
G5V58_RS18935	COG0477	Major facilitator Superfamily
G5V58_RS18955	COG0438	transferase activity, transferring glycosyl groups
G5V58_RS18970	COG1794	racemase activity, acting on amino acids and derivatives
G5V58_RS18990	COG1217	gtp-binding protein TYPA
G5V58_RS18995	COG3386	PFAM SMP-30 Gluconolaconase
G5V58_RS19005	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS19020	COG2030	dehydratase
G5V58_RS19035	COG0446	pyridine nucleotide-disulphide oxidoreductase
G5V58_RS19035	COG1902	pentaerythritol trinitrate reductase activity
G5V58_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS19050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS19085	COG1024	Enoyl-CoA hydratase
G5V58_RS19110	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS19130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G5V58_RS19135	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS19145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS19155	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS19170	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS19185	COG0183	Belongs to the thiolase family
G5V58_RS19195	COG1024	Enoyl-CoA hydratase
G5V58_RS19215	COG1024	Enoyl-CoA hydratase
G5V58_RS19220	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS19225	COG2186	Transcriptional regulator
G5V58_RS19245	COG0559	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS19260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G5V58_RS19300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G5V58_RS19315	COG0674	pyruvate-flavodoxin oxidoreductase activity
G5V58_RS19315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G5V58_RS19320	COG1013	pyruvate-flavodoxin oxidoreductase activity
G5V58_RS19330	COG1764	response to oxidative stress
G5V58_RS19335	COG1846	Transcriptional regulator
G5V58_RS19375	COG1846	Transcriptional regulator
G5V58_RS19395	COG1703	isobutyryl-CoA mutase activity
G5V58_RS19395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G5V58_RS19395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G5V58_RS19405	COG5002	protein histidine kinase activity
G5V58_RS19450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G5V58_RS19455	COG1088	dTDP-glucose 4,6-dehydratase activity
G5V58_RS19490	COG0730	response to heat
G5V58_RS19495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G5V58_RS19500	COG0175	sulfate reduction
G5V58_RS19525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G5V58_RS19550	COG5002	protein histidine kinase activity
G5V58_RS19560	COG0745	RESPONSE REGULATOR receiver
G5V58_RS19565	COG0454	-acetyltransferase
G5V58_RS19565	COG0456	acetyltransferase
G5V58_RS19575	COG0354	folic acid binding
G5V58_RS19585	COG4044	May play a role in the intracellular transport of hydrophobic ligands
G5V58_RS19590	COG1490	D-aminoacyl-tRNA deacylase activity
G5V58_RS19600	COG3246	L-lysine catabolic process to acetate
G5V58_RS19625	COG0657	acetylesterase activity
G5V58_RS19640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G5V58_RS19650	COG0306	phosphate transporter
G5V58_RS19660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G5V58_RS19680	COG0406	alpha-ribazole phosphatase activity
G5V58_RS19680	COG0494	nUDIX hydrolase
G5V58_RS19705	COG1937	Protein conserved in bacteria
G5V58_RS19715	COG1278	Cold shock
G5V58_RS19730	COG3485	protocatechuate 3,4-dioxygenase
G5V58_RS19735	COG1454	alcohol dehydrogenase
G5V58_RS19750	COG4177	L-phenylalanine transmembrane transporter activity
G5V58_RS19760	COG0410	ABC transporter
G5V58_RS19765	COG1137	ATPase activity
G5V58_RS19780	COG4251	negative regulation of phosphorylation
G5V58_RS19800	COG0477	Major facilitator Superfamily
G5V58_RS19805	COG2267	carboxylic ester hydrolase activity
G5V58_RS19820	COG0747	negative chemotaxis
G5V58_RS19825	COG0601	transmembrane transport
G5V58_RS19830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G5V58_RS19845	COG3246	L-lysine catabolic process to acetate
G5V58_RS19850	COG1250	3-hydroxyacyl-CoA dehydrogenase
G5V58_RS19875	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS19880	COG0515	serine threonine protein kinase
G5V58_RS19900	COG1333	cytochrome c biogenesis protein
G5V58_RS19905	COG0785	Cytochrome C biogenesis protein
G5V58_RS19915	COG0406	alpha-ribazole phosphatase activity
G5V58_RS19920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G5V58_RS19930	COG0113	porphobilinogen synthase activity
G5V58_RS19935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G5V58_RS19935	COG1648	precorrin-2 dehydrogenase activity
G5V58_RS19940	COG0181	hydroxymethylbilane synthase activity
G5V58_RS19950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G5V58_RS19960	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS19970	COG1595	DNA-templated transcription, initiation
G5V58_RS20000	COG0123	including yeast histone deacetylase and acetoin utilization protein
G5V58_RS20005	COG0180	Tryptophanyl-tRNA synthetase
G5V58_RS20015	COG0596	Alpha beta hydrolase
G5V58_RS20025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G5V58_RS20030	COG0506	proline dehydrogenase activity
G5V58_RS20040	COG1131	(ABC) transporter
G5V58_RS20050	COG2409	Drug exporters of the RND superfamily
G5V58_RS20055	COG4585	Histidine kinase
G5V58_RS20060	COG2197	response regulator
G5V58_RS20065	COG1082	Xylose isomerase domain protein TIM barrel
G5V58_RS20070	COG0248	Ppx GppA phosphatase
G5V58_RS20085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G5V58_RS20090	COG1609	Transcriptional regulator
G5V58_RS20095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G5V58_RS20100	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G5V58_RS20155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G5V58_RS20160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G5V58_RS20165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G5V58_RS20175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G5V58_RS20190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G5V58_RS20200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G5V58_RS20205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G5V58_RS20210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G5V58_RS20230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G5V58_RS20230	COG2755	lipolytic protein G-D-S-L family
G5V58_RS20285	COG1174	glycine betaine transport
G5V58_RS20290	COG1174	glycine betaine transport
G5V58_RS20295	COG0517	IMP dehydrogenase activity
G5V58_RS20295	COG1125	glycine betaine transport
G5V58_RS20335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G5V58_RS20340	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G5V58_RS20345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G5V58_RS20375	COG0302	gtp cyclohydrolase
G5V58_RS20390	COG0037	tRNA processing
G5V58_RS20410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G5V58_RS20425	COG0151	Belongs to the GarS family
G5V58_RS20430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G5V58_RS20440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G5V58_RS20460	COG0191	fructose-bisphosphate aldolase activity
G5V58_RS20485	COG0586	Pfam SNARE associated Golgi protein
G5V58_RS20490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G5V58_RS20505	COG0542	response to heat
G5V58_RS20520	COG2201	protein-glutamate methylesterase activity
G5V58_RS20525	COG0789	Transcriptional regulator
G5V58_RS20530	COG0484	heat shock protein binding
G5V58_RS20535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G5V58_RS20540	COG0443	Heat shock 70 kDa protein
G5V58_RS20545	COG2234	aminopeptidase activity
G5V58_RS20600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G5V58_RS20605	COG4214	carbohydrate transport
G5V58_RS20640	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS20715	COG0583	DNA-binding transcription factor activity
G5V58_RS20725	COG0596	Alpha beta hydrolase
G5V58_RS20730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G5V58_RS20735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G5V58_RS20740	COG0387	Pfam Sodium calcium exchanger
G5V58_RS20745	COG1846	Transcriptional regulator
G5V58_RS20745	COG1940	carbohydrate kinase activity
G5V58_RS20755	COG1175	transmembrane transport
G5V58_RS20760	COG0395	ABC-type sugar transport system, permease component
G5V58_RS20765	COG1063	alcohol dehydrogenase
G5V58_RS20780	COG0366	Alpha amylase catalytic
G5V58_RS20795	COG1754	DNA topoisomerase type I activity
G5V58_RS20795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G5V58_RS20800	COG2890	protein-(glutamine-N5) methyltransferase activity
G5V58_RS20810	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G5V58_RS20815	COG1366	Belongs to the anti-sigma-factor antagonist family
G5V58_RS20820	COG1205	dead DEAH box helicase
G5V58_RS20820	COG1111	helicase
G5V58_RS20900	COG3275	phosphorelay sensor kinase activity
G5V58_RS20905	COG3279	Response regulator of the LytR AlgR family
G5V58_RS20925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G5V58_RS20945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G5V58_RS20965	COG1304	FMN binding
G5V58_RS20970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G5V58_RS20980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5V58_RS20985	COG0494	nUDIX hydrolase
G5V58_RS21005	COG1595	DNA-templated transcription, initiation
G5V58_RS21015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G5V58_RS21025	COG0251	oxidation-reduction process
G5V58_RS21075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G5V58_RS21120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G5V58_RS21125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G5V58_RS21150	COG2197	response regulator
G5V58_RS21160	COG0328	RNA-DNA hybrid ribonuclease activity
G5V58_RS21195	COG1674	ftsk spoiiie
G5V58_RS21210	COG1404	Belongs to the peptidase S8 family
G5V58_RS21215	COG0433	COG0433 Predicted ATPase
G5V58_RS21230	COG3263	regulation of cellular component size
G5V58_RS21255	COG0436	Aminotransferase
G5V58_RS21270	COG0667	Aldo Keto reductase
G5V58_RS21295	COG0542	response to heat
G5V58_RS21305	COG1024	Enoyl-CoA hydratase
G5V58_RS21335	COG2814	Major facilitator Superfamily
G5V58_RS21355	COG0590	tRNA wobble adenosine to inosine editing
G5V58_RS21355	COG0037	tRNA processing
G5V58_RS21370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G5V58_RS21400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G5V58_RS21410	COG0477	Major facilitator Superfamily
G5V58_RS21455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G5V58_RS21465	COG2226	methyltransferase
G5V58_RS21490	COG1653	transport
G5V58_RS21495	COG1175	transmembrane transport
G5V58_RS21505	COG1472	Belongs to the glycosyl hydrolase 3 family
G5V58_RS21510	COG1609	Transcriptional regulator
G5V58_RS21530	COG1074	ATP-dependent DNA helicase activity
G5V58_RS21535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
G5V58_RS21565	COG3552	Protein containing von Willebrand factor type A (VWA) domain
G5V58_RS21575	COG0714	Associated with various cellular activities
G5V58_RS21620	COG2133	pyrroloquinoline quinone binding
G5V58_RS21625	COG2409	Drug exporters of the RND superfamily
G5V58_RS21655	COG1595	DNA-templated transcription, initiation
G5V58_RS21680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G5V58_RS21740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G5V58_RS21745	COG0746	molybdenum cofactor guanylyltransferase activity
G5V58_RS21770	COG0561	phosphatase activity
G5V58_RS21780	COG0561	phosphatase activity
G5V58_RS21785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G5V58_RS21800	COG1595	DNA-templated transcription, initiation
G5V58_RS21815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G5V58_RS21820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G5V58_RS21860	COG0488	(ABC) transporter
G5V58_RS21875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G5V58_RS21885	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS21925	COG1136	(ABC) transporter
G5V58_RS21930	COG1695	Transcriptional regulator
G5V58_RS21945	COG0402	S-adenosylhomocysteine deaminase activity
G5V58_RS21950	COG1414	Transcriptional regulator
G5V58_RS21955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G5V58_RS21965	COG3485	protocatechuate 3,4-dioxygenase
G5V58_RS21985	COG1129	ABC transporter
G5V58_RS21985	COG0842	Transport permease protein
G5V58_RS22005	COG1802	Transcriptional regulator
G5V58_RS22030	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS22045	COG1137	ATPase activity
G5V58_RS22055	COG1172	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS22070	COG1309	transcriptional regulator
G5V58_RS22080	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS22090	COG0183	Belongs to the thiolase family
G5V58_RS22105	COG0702	epimerase
G5V58_RS22115	COG0513	Belongs to the DEAD box helicase family
G5V58_RS22140	COG0519	Catalyzes the synthesis of GMP from XMP
G5V58_RS22140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G5V58_RS22145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G5V58_RS22160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G5V58_RS22165	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS22175	COG2197	response regulator
G5V58_RS22180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G5V58_RS22190	COG1126	abc transporter atp-binding protein
G5V58_RS22195	COG0765	amino acid transport
G5V58_RS22200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G5V58_RS22225	COG2723	6-phospho-beta-galactosidase activity
G5V58_RS22240	COG1597	lipid kinase activity
G5V58_RS22245	COG0277	FAD linked oxidase domain protein
G5V58_RS22295	COG0604	alcohol dehydrogenase
G5V58_RS22310	COG2268	Band 7 protein
G5V58_RS22325	COG2755	lipolytic protein G-D-S-L family
G5V58_RS22335	COG0644	oxidoreductase
G5V58_RS22350	COG0531	amino acid
G5V58_RS22370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G5V58_RS22390	COG0454	-acetyltransferase
G5V58_RS22390	COG0456	acetyltransferase
G5V58_RS22405	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS22450	COG0339	signal peptide processing
G5V58_RS22455	COG4941	Belongs to the sigma-70 factor family
G5V58_RS22490	COG1929	Belongs to the glycerate kinase type-1 family
G5V58_RS22505	COG5564	TIM-barrel signal transduction protein
G5V58_RS22510	COG1063	alcohol dehydrogenase
G5V58_RS22535	COG3246	L-lysine catabolic process to acetate
G5V58_RS22575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5V58_RS22625	COG0305	Participates in initiation and elongation during chromosome replication
G5V58_RS22635	COG0183	Belongs to the thiolase family
G5V58_RS22650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G5V58_RS22660	COG0640	Transcriptional regulator
G5V58_RS22680	COG0359	binds to the 23S rRNA
G5V58_RS22685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G5V58_RS22690	COG0629	single-stranded DNA binding
G5V58_RS22695	COG0360	Binds together with S18 to 16S ribosomal RNA
G5V58_RS22700	COG0515	serine threonine protein kinase
G5V58_RS22720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G5V58_RS22770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G5V58_RS22780	COG1260	myo-inositol-1-phosphate synthase
G5V58_RS22795	COG0617	tRNA 3'-terminal CCA addition
G5V58_RS22815	COG1595	DNA-templated transcription, initiation
G5V58_RS22825	COG0492	ferredoxin-NADP+ reductase activity
G5V58_RS22830	COG3118	belongs to the thioredoxin family
G5V58_RS22840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G5V58_RS22850	COG1475	DNA binding
G5V58_RS22855	COG1192	Involved in chromosome partitioning
G5V58_RS22860	COG0357	Ribosomal RNA small subunit methyltransferase G
G5V58_RS22870	COG0706	membrane insertase activity
G5V58_RS22875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G5V58_RS22880	COG0594	ribonuclease P activity
G5V58_RS22885	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G5V58_RS22890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G5V58_RS22895	COG0592	DNA-directed DNA polymerase activity
G5V58_RS22900	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G5V58_RS22905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G5V58_RS22910	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
G5V58_RS22920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G5V58_RS22950	COG1595	DNA-templated transcription, initiation
G5V58_RS22990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G5V58_RS22995	COG0705	Rhomboid family
G5V58_RS22995	COG0457	Tetratricopeptide repeat
G5V58_RS23010	COG0515	serine threonine protein kinase
G5V58_RS23015	COG0515	serine threonine protein kinase
G5V58_RS23020	COG0768	penicillin binding
G5V58_RS23040	COG1716	ATPase activity
G5V58_RS23095	COG0386	Belongs to the glutathione peroxidase family
G5V58_RS23115	COG1940	carbohydrate kinase activity
G5V58_RS23145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G5V58_RS23165	COG0477	Major facilitator Superfamily
G5V58_RS23200	COG5012	cobalamin binding
G5V58_RS23230	COG2409	Drug exporters of the RND superfamily
G5V58_RS23240	COG1414	Transcriptional regulator
G5V58_RS23245	COG1012	belongs to the aldehyde dehydrogenase family
G5V58_RS23250	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G5V58_RS23255	COG0517	IMP dehydrogenase activity
G5V58_RS23255	COG4175	Glycine betaine
G5V58_RS23270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G5V58_RS23275	COG1902	pentaerythritol trinitrate reductase activity
G5V58_RS23285	COG2086	electron transfer activity
G5V58_RS23290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G5V58_RS23300	COG1660	Displays ATPase and GTPase activities
G5V58_RS23325	COG1846	Transcriptional regulator
G5V58_RS23340	COG3590	peptidase
G5V58_RS23350	COG4566	intracellular signal transduction
G5V58_RS23375	COG0514	ATP-dependent DNA helicase (RecQ)
G5V58_RS23380	COG2084	Dehydrogenase
G5V58_RS23390	COG0386	Belongs to the glutathione peroxidase family
G5V58_RS23395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G5V58_RS23415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G5V58_RS23425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G5V58_RS23435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5V58_RS23460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G5V58_RS23475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G5V58_RS23475	COG0425	Belongs to the sulfur carrier protein TusA family
G5V58_RS23485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G5V58_RS23510	COG0653	protein targeting
G5V58_RS23515	COG2267	carboxylic ester hydrolase activity
G5V58_RS23520	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G5V58_RS23540	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
G5V58_RS23545	COG1691	(AIR) carboxylase
G5V58_RS23550	COG0077	Prephenate dehydratase
G5V58_RS23550	COG1605	Chorismate mutase
G5V58_RS23570	COG0477	Major facilitator Superfamily
G5V58_RS23590	COG1024	Enoyl-CoA hydratase
G5V58_RS23620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G5V58_RS23630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G5V58_RS23630	COG0512	Glutamine amidotransferase of anthranilate synthase
G5V58_RS23635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G5V58_RS23640	COG2205	protein histidine kinase activity
G5V58_RS23645	COG0745	RESPONSE REGULATOR receiver
G5V58_RS23665	COG3001	Fructosamine kinase
G5V58_RS23675	COG1950	PFAM Membrane protein of
G5V58_RS23680	COG1802	Transcriptional regulator
G5V58_RS23690	COG1113	amino acid transport
G5V58_RS23700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G5V58_RS23710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G5V58_RS23720	COG0667	Aldo Keto reductase
G5V58_RS23740	COG2308	Evidence 4 Homologs of previously reported genes of
G5V58_RS23740	COG2307	Protein conserved in bacteria
G5V58_RS23750	COG0454	-acetyltransferase
G5V58_RS23765	COG0435	Glutathione S-transferase
G5V58_RS23790	COG1366	Belongs to the anti-sigma-factor antagonist family
G5V58_RS23795	COG1215	transferase activity, transferring glycosyl groups
G5V58_RS23810	COG0022	dehydrogenase e1 component
G5V58_RS23815	COG0508	dehydrogenase complex catalyzes the overall conversion of
G5V58_RS23905	COG4941	Belongs to the sigma-70 factor family
G5V58_RS23910	COG3795	YCII-related domain
G5V58_RS23920	COG1940	carbohydrate kinase activity
G5V58_RS23925	COG1653	transport
G5V58_RS23930	COG1175	transmembrane transport
G5V58_RS23935	COG0395	ABC-type sugar transport system, permease component
G5V58_RS23940	COG1472	Belongs to the glycosyl hydrolase 3 family
G5V58_RS23945	COG1940	carbohydrate kinase activity
G5V58_RS23995	COG0154	amidase activity
G5V58_RS24025	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5V58_RS24070	COG0300	oxidoreductase activity
G5V58_RS24100	COG0583	DNA-binding transcription factor activity
G5V58_RS24105	COG1960	acyl-CoA dehydrogenase activity
G5V58_RS24110	COG0730	response to heat
G5V58_RS24150	COG0717	Belongs to the dCTP deaminase family
G5V58_RS24175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G5V58_RS24190	COG0247	lactate metabolic process
G5V58_RS24190	COG2181	nitrate reductase activity
G5V58_RS24215	COG3973	AAA domain
G5V58_RS24245	COG0531	amino acid
G5V58_RS24265	COG4585	Histidine kinase
G5V58_RS24270	COG2197	response regulator
G5V58_RS24280	COG2271	Major facilitator Superfamily
G5V58_RS24305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G5V58_RS24320	COG0501	Belongs to the peptidase M48B family
G5V58_RS24330	COG2301	Belongs to the HpcH HpaI aldolase family
G5V58_RS24335	COG2301	Belongs to the HpcH HpaI aldolase family
G5V58_RS24350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5V58_RS24360	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G5V58_RS24360	COG0778	Nitroreductase
G5V58_RS24370	COG0402	S-adenosylhomocysteine deaminase activity
G5V58_RS24375	COG1228	amidohydrolase
G5V58_RS24385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G5V58_RS24385	COG1672	PFAM Archaeal ATPase
G5V58_RS24415	COG0644	oxidoreductase
G5V58_RS24425	COG1755	Isoprenylcysteine carboxyl methyltransferase
G5V58_RS24435	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G5V58_RS24450	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS24460	COG2072	flavoprotein involved in K transport
G5V58_RS24480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G5V58_RS24505	COG1309	transcriptional regulator
G5V58_RS24515	COG1959	2 iron, 2 sulfur cluster binding
G5V58_RS24530	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS24560	COG2313	pseudouridylate synthase activity
G5V58_RS24565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G5V58_RS24570	COG0514	ATP-dependent DNA helicase (RecQ)
G5V58_RS24575	COG0596	Alpha beta hydrolase
G5V58_RS24590	COG2890	protein-(glutamine-N5) methyltransferase activity
G5V58_RS24605	COG2409	Drug exporters of the RND superfamily
G5V58_RS24660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G5V58_RS24675	COG4143	(ABC) transporter
G5V58_RS24685	COG3842	ATPase activity
G5V58_RS24715	COG2027	D-alanyl-D-alanine carboxypeptidase
G5V58_RS24740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G5V58_RS24750	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS24780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G5V58_RS24785	COG0047	phosphoribosylformylglycinamidine synthase activity
G5V58_RS24810	COG1309	transcriptional regulator
G5V58_RS24820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G5V58_RS24865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G5V58_RS24885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5V58_RS24900	COG0784	Response regulator, receiver
G5V58_RS24900	COG2205	protein histidine kinase activity
G5V58_RS24910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G5V58_RS24935	COG1595	DNA-templated transcription, initiation
G5V58_RS24950	COG1595	DNA-templated transcription, initiation
G5V58_RS24965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G5V58_RS25040	COG1802	Transcriptional regulator
G5V58_RS25060	COG1175	transmembrane transport
G5V58_RS25065	COG0395	ABC-type sugar transport system, permease component
G5V58_RS25070	COG3842	ATPase activity
G5V58_RS25095	COG1028	Short-chain dehydrogenase reductase Sdr
G5V58_RS25130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G5V58_RS25135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G5V58_RS25145	COG1252	NADH dehydrogenase
G5V58_RS25200	COG4948	Mandelate Racemase Muconate Lactonizing
G5V58_RS25290	COG1169	isochorismate synthase
G5V58_RS25305	COG2226	methyltransferase
G5V58_RS25315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5V58_RS25320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5V58_RS25325	COG0649	NAD binding
G5V58_RS25335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G5V58_RS25340	COG1034	ATP synthesis coupled electron transport
G5V58_RS25345	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G5V58_RS25350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5V58_RS25360	COG0713	ATP synthesis coupled electron transport
G5V58_RS25375	COG1007	ATP synthesis coupled electron transport
G5V58_RS25380	COG0142	geranyltranstransferase activity
G5V58_RS25400	COG1013	pyruvate-flavodoxin oxidoreductase activity
G5V58_RS25405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G5V58_RS25405	COG0674	pyruvate-flavodoxin oxidoreductase activity
G5V58_RS25420	COG4208	sulfate ABC transporter
G5V58_RS25430	COG0644	oxidoreductase
G5V58_RS25440	COG1666	GTP binding
G5V58_RS25475	COG1129	ABC transporter
G5V58_RS25480	COG1172	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS25485	COG1172	Belongs to the binding-protein-dependent transport system permease family
G5V58_RS25495	COG0318	PFAM AMP-dependent synthetase and ligase
G5V58_RS25505	COG0463	Glycosyl transferase, family 2
G5V58_RS25515	COG0346	lactoylglutathione lyase activity
G5V58_RS25545	COG2197	response regulator
G5V58_RS25550	COG0596	Alpha beta hydrolase
G5V58_RS25555	COG1295	ribonuclease BN