locus-tag	class	description
E3N83_RS00010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3N83_RS00075	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E3N83_RS00105	COG1793	dna ligase
E3N83_RS00105	COG3285	dna ligase
E3N83_RS00115	COG0745	RESPONSE REGULATOR receiver
E3N83_RS00145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E3N83_RS00175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3N83_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS00275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3N83_RS00285	COG1595	DNA-templated transcription, initiation
E3N83_RS00290	COG2884	Cell division ATP-binding protein ftsE
E3N83_RS00295	COG2177	Part of the ABC transporter FtsEX involved in
E3N83_RS00305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E3N83_RS00355	COG0537	adenosine 5'-monophosphoramidase activity
E3N83_RS00365	COG0542	response to heat
E3N83_RS00380	COG1470	cell adhesion involved in biofilm formation
E3N83_RS00385	COG1309	transcriptional regulator
E3N83_RS00395	COG1678	Uncharacterized ACR, COG1678
E3N83_RS00410	COG1846	Transcriptional regulator
E3N83_RS00410	COG0456	acetyltransferase
E3N83_RS00420	COG3185	4-Hydroxyphenylpyruvate dioxygenase
E3N83_RS00425	COG0737	Belongs to the 5'-nucleotidase family
E3N83_RS00440	COG1024	Enoyl-CoA hydratase
E3N83_RS00450	COG1335	isochorismatase
E3N83_RS00460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E3N83_RS00495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3N83_RS00500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E3N83_RS00505	COG1234	tRNA 3'-trailer cleavage
E3N83_RS00520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E3N83_RS00525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3N83_RS00550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3N83_RS00555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E3N83_RS00585	COG1741	Belongs to the pirin family
E3N83_RS00600	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E3N83_RS00620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3N83_RS00635	COG2205	protein histidine kinase activity
E3N83_RS00645	COG2197	response regulator
E3N83_RS00690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS00695	COG0006	proline dipeptidase activity
E3N83_RS00715	COG0629	single-stranded DNA binding
E3N83_RS00730	COG0183	Belongs to the thiolase family
E3N83_RS00770	COG0668	transmembrane transport
E3N83_RS00790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E3N83_RS00795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3N83_RS00805	COG4552	Acetyltransferase involved in intracellular survival and related
E3N83_RS00840	COG0544	peptidyl-prolyl cis-trans isomerase activity
E3N83_RS00850	COG0740	serine-type endopeptidase activity
E3N83_RS00855	COG0740	serine-type endopeptidase activity
E3N83_RS00860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E3N83_RS00870	COG0525	valine-tRNA ligase activity
E3N83_RS00885	COG0285	dihydrofolate synthase activity
E3N83_RS00905	COG0105	UTP biosynthetic process
E3N83_RS00920	COG1077	Cell shape determining protein MreB Mrl
E3N83_RS00940	COG0772	Belongs to the SEDS family
E3N83_RS00960	COG2814	Major facilitator Superfamily
E3N83_RS00995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3N83_RS01000	COG2807	transmembrane transport
E3N83_RS01015	COG1530	ribonuclease E activity
E3N83_RS01025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E3N83_RS01030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3N83_RS01035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E3N83_RS01040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3N83_RS01070	COG0482	sulfurtransferase activity
E3N83_RS01110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E3N83_RS01130	COG1595	DNA-templated transcription, initiation
E3N83_RS01135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3N83_RS01140	COG0154	amidase activity
E3N83_RS01145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E3N83_RS01175	COG3845	ABC transporter
E3N83_RS01190	COG5006	permease, DMT superfamily
E3N83_RS01220	COG0477	Major facilitator Superfamily
E3N83_RS01225	COG0129	dihydroxy-acid dehydratase activity
E3N83_RS01235	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3N83_RS01260	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3N83_RS01270	COG0440	acetolactate synthase activity
E3N83_RS01275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E3N83_RS01280	COG2226	methyltransferase
E3N83_RS01300	COG0542	response to heat
E3N83_RS01330	COG0531	amino acid
E3N83_RS01340	COG0473	3-isopropylmalate dehydrogenase activity
E3N83_RS01345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3N83_RS01360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3N83_RS01385	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3N83_RS01390	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E3N83_RS01390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E3N83_RS01425	COG0456	acetyltransferase
E3N83_RS01430	COG1414	Transcriptional regulator
E3N83_RS01435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E3N83_RS01440	COG0066	3-isopropylmalate dehydratase activity
E3N83_RS01450	COG0776	regulation of translation
E3N83_RS01465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E3N83_RS01470	COG0626	cystathionine gamma-synthase activity
E3N83_RS01475	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3N83_RS01495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E3N83_RS01500	COG1461	Dihydroxyacetone kinase
E3N83_RS01510	COG0742	ribosomal rna small subunit methyltransferase
E3N83_RS01515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E3N83_RS01520	COG1399	metal-binding, possibly nucleic acid-binding protein
E3N83_RS01525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3N83_RS01530	COG0571	ribonuclease III activity
E3N83_RS01535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3N83_RS01550	COG2814	Major facilitator Superfamily
E3N83_RS01590	COG0612	Peptidase, M16
E3N83_RS01615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E3N83_RS01640	COG1940	carbohydrate kinase activity
E3N83_RS01655	COG2890	protein-(glutamine-N5) methyltransferase activity
E3N83_RS01660	COG0228	four-way junction DNA binding
E3N83_RS01665	COG1837	Belongs to the UPF0109 family
E3N83_RS01670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E3N83_RS01675	COG0336	Belongs to the RNA methyltransferase TrmD family
E3N83_RS01685	COG0335	large ribosomal subunit rRNA binding
E3N83_RS01695	COG0681	Belongs to the peptidase S26 family
E3N83_RS01700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E3N83_RS01720	COG0792	nuclease activity
E3N83_RS01740	COG4974	Belongs to the 'phage' integrase family
E3N83_RS01755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E3N83_RS01760	COG0528	UMP kinase activity
E3N83_RS01765	COG0233	cytoplasmic translational termination
E3N83_RS01790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E3N83_RS01805	COG0308	aminopeptidase N
E3N83_RS01810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3N83_RS01825	COG3842	ATPase activity
E3N83_RS01830	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3N83_RS01835	COG1177	transmembrane transport
E3N83_RS01840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3N83_RS01845	COG0010	Belongs to the arginase family
E3N83_RS01875	COG3842	ATPase activity
E3N83_RS01880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E3N83_RS01885	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3N83_RS01890	COG1177	transmembrane transport
E3N83_RS01895	COG2207	Transcriptional regulator
E3N83_RS01905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS01915	COG0018	arginyl-trna synthetase
E3N83_RS01935	COG1834	amidinotransferase
E3N83_RS01940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E3N83_RS01945	COG0750	zinc metalloprotease
E3N83_RS01950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E3N83_RS01985	COG0442	prolyl-tRNA aminoacylation
E3N83_RS02005	COG0779	Required for maturation of 30S ribosomal subunits
E3N83_RS02010	COG0195	Participates in both transcription termination and antitermination
E3N83_RS02015	COG1794	racemase activity, acting on amino acids and derivatives
E3N83_RS02030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E3N83_RS02035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3N83_RS02040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E3N83_RS02045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E3N83_RS02050	COG0415	Belongs to the DNA photolyase family
E3N83_RS02065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3N83_RS02070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3N83_RS02070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3N83_RS02070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3N83_RS02085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3N83_RS02090	COG3383	formate dehydrogenase (NAD+) activity
E3N83_RS02100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E3N83_RS02105	COG1185	polyribonucleotide nucleotidyltransferase activity
E3N83_RS02110	COG0612	Peptidase, M16
E3N83_RS02135	COG1595	DNA-templated transcription, initiation
E3N83_RS02140	COG1063	alcohol dehydrogenase
E3N83_RS02145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3N83_RS02145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3N83_RS02170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E3N83_RS02200	COG3396	Phenylacetate-CoA oxygenase
E3N83_RS02205	COG3460	Phenylacetate-CoA oxygenase
E3N83_RS02210	COG3396	Phenylacetate-CoA oxygenase
E3N83_RS02215	COG2151	metal-sulfur cluster biosynthetic enzyme
E3N83_RS02220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3N83_RS02240	COG0501	Belongs to the peptidase M48B family
E3N83_RS02260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E3N83_RS02270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E3N83_RS02300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3N83_RS02310	COG1104	cysteine desulfurase activity
E3N83_RS02315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3N83_RS02320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3N83_RS02330	COG1376	ErfK ybiS ycfS ynhG family protein
E3N83_RS02340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3N83_RS02345	COG0723	plastoquinol--plastocyanin reductase activity
E3N83_RS02355	COG1845	cytochrome c oxidase, subunit III
E3N83_RS02370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E3N83_RS02385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3N83_RS02390	COG1420	regulation of RNA biosynthetic process
E3N83_RS02395	COG0484	heat shock protein binding
E3N83_RS02410	COG1191	sigma factor activity
E3N83_RS02415	COG0537	adenosine 5'-monophosphoramidase activity
E3N83_RS02430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E3N83_RS02440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3N83_RS02525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3N83_RS02540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3N83_RS02595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3N83_RS02610	COG0596	Alpha beta hydrolase
E3N83_RS02615	COG1381	Involved in DNA repair and RecF pathway recombination
E3N83_RS02620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3N83_RS02630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3N83_RS02635	COG1121	(ABC) transporter
E3N83_RS02640	COG3443	Belongs to the bacterial solute-binding protein 9 family
E3N83_RS02640	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3N83_RS02655	COG0423	glycine-tRNA ligase activity
E3N83_RS02675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E3N83_RS02685	COG1295	ribonuclease BN
E3N83_RS02725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS02775	COG3012	SEC-C Motif Domain Protein
E3N83_RS02785	COG1454	alcohol dehydrogenase
E3N83_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS02800	COG0515	serine threonine protein kinase
E3N83_RS02800	COG2815	serine threonine protein kinase
E3N83_RS02810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E3N83_RS02815	COG1304	FMN binding
E3N83_RS02855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3N83_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3N83_RS02865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3N83_RS02885	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E3N83_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS02935	COG3022	response to hydroperoxide
E3N83_RS02940	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
E3N83_RS02945	COG0656	L-ascorbic acid biosynthetic process
E3N83_RS02995	COG2197	response regulator
E3N83_RS03000	COG4585	Histidine kinase
E3N83_RS03005	COG0842	Transport permease protein
E3N83_RS03010	COG1131	(ABC) transporter
E3N83_RS03015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E3N83_RS03025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS03045	COG0505	Belongs to the CarA family
E3N83_RS03050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E3N83_RS03090	COG0667	Aldo Keto reductase
E3N83_RS03110	COG0298	carbon dioxide binding
E3N83_RS03115	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E3N83_RS03120	COG2318	DinB family
E3N83_RS03150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E3N83_RS03155	COG0321	lipoyl(octanoyl) transferase activity
E3N83_RS03170	COG1090	epimerase
E3N83_RS03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS03180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3N83_RS03190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3N83_RS03195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3N83_RS03255	COG1902	pentaerythritol trinitrate reductase activity
E3N83_RS03265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3N83_RS03290	COG1725	Transcriptional regulator
E3N83_RS03295	COG2313	pseudouridylate synthase activity
E3N83_RS03300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3N83_RS03310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3N83_RS03315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E3N83_RS03340	COG1674	ftsk spoiiie
E3N83_RS03350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3N83_RS03365	COG3387	PFAM Glycoside hydrolase 15-related
E3N83_RS03370	COG1058	Belongs to the CinA family
E3N83_RS03370	COG1546	Belongs to the CinA family
E3N83_RS03375	COG1396	sequence-specific DNA binding
E3N83_RS03380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3N83_RS03385	COG1201	RNA secondary structure unwinding
E3N83_RS03390	COG4941	Belongs to the sigma-70 factor family
E3N83_RS03405	COG1131	(ABC) transporter
E3N83_RS03425	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3N83_RS03430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3N83_RS03475	COG5002	protein histidine kinase activity
E3N83_RS03495	COG1280	lysine exporter protein (LysE YggA)
E3N83_RS03505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E3N83_RS03510	COG2137	regulation of response to DNA damage stimulus
E3N83_RS03515	COG2326	polyphosphate kinase activity
E3N83_RS03540	COG0175	sulfate reduction
E3N83_RS03560	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E3N83_RS03565	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS03575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3N83_RS03605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3N83_RS03615	COG2910	NAD(P)H-binding
E3N83_RS03625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3N83_RS03640	COG0483	inositol monophosphate 1-phosphatase activity
E3N83_RS03650	COG0028	Belongs to the TPP enzyme family
E3N83_RS03665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3N83_RS03670	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E3N83_RS03680	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E3N83_RS03685	COG0217	transcriptional regulatory protein
E3N83_RS03690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E3N83_RS03695	COG0632	four-way junction helicase activity
E3N83_RS03700	COG2255	four-way junction helicase activity
E3N83_RS03705	COG1862	Preprotein translocase
E3N83_RS03715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3N83_RS03720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3N83_RS03765	COG2154	pterin-4-alpha-carbinolamine dehydratase
E3N83_RS03770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3N83_RS03775	COG1196	nuclear chromosome segregation
E3N83_RS03785	COG0124	histidyl-tRNA synthetase
E3N83_RS03790	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E3N83_RS03795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3N83_RS03800	COG4166	transmembrane transport
E3N83_RS03815	COG4608	Belongs to the ABC transporter superfamily
E3N83_RS03835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E3N83_RS03840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E3N83_RS03850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3N83_RS03855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3N83_RS03860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E3N83_RS03865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3N83_RS03870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E3N83_RS03875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E3N83_RS03890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E3N83_RS03895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3N83_RS03910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3N83_RS03915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E3N83_RS03920	COG0540	Belongs to the ATCase OTCase family
E3N83_RS03925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3N83_RS03940	COG2267	carboxylic ester hydrolase activity
E3N83_RS03945	COG4106	trans-aconitate 2-methyltransferase activity
E3N83_RS03960	COG0488	(ABC) transporter
E3N83_RS03970	COG3214	Protein conserved in bacteria
E3N83_RS03985	COG0505	Belongs to the CarA family
E3N83_RS03990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3N83_RS03995	COG0167	dihydroorotate dehydrogenase activity
E3N83_RS04005	COG0167	dihydroorotate dehydrogenase activity
E3N83_RS04010	COG0284	orotidine-5'-phosphate decarboxylase activity
E3N83_RS04020	COG0194	GDP metabolic process
E3N83_RS04025	COG1758	RNA polymerase activity
E3N83_RS04035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E3N83_RS04050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3N83_RS04060	COG0242	peptide deformylase activity
E3N83_RS04065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E3N83_RS04085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3N83_RS04100	COG3201	nicotinamide mononucleotide transporter
E3N83_RS04105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3N83_RS04105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E3N83_RS04110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E3N83_RS04115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3N83_RS04125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3N83_RS04130	COG0140	phosphoribosyl-ATP diphosphatase activity
E3N83_RS04135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E3N83_RS04145	COG2017	converts alpha-aldose to the beta-anomer
E3N83_RS04170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS04175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3N83_RS04180	COG1116	anion transmembrane transporter activity
E3N83_RS04185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3N83_RS04195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3N83_RS04200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E3N83_RS04205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3N83_RS04210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3N83_RS04220	COG5002	protein histidine kinase activity
E3N83_RS04225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3N83_RS04230	COG0072	phenylalanine-tRNA ligase activity
E3N83_RS04230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3N83_RS04245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E3N83_RS04250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E3N83_RS04255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E3N83_RS04260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3N83_RS04265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3N83_RS04270	COG1438	arginine binding
E3N83_RS04275	COG0137	argininosuccinate synthase activity
E3N83_RS04285	COG0165	Argininosuccinate lyase
E3N83_RS04290	COG2094	Belongs to the DNA glycosylase MPG family
E3N83_RS04325	COG0647	UMP catabolic process
E3N83_RS04340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3N83_RS04345	COG0497	DNA recombination
E3N83_RS04360	COG0504	CTP synthase activity
E3N83_RS04370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3N83_RS04375	COG0765	amino acid transport
E3N83_RS04395	COG0686	Belongs to the AlaDH PNT family
E3N83_RS04410	COG2018	Roadblock/LC7 domain
E3N83_RS04425	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS04445	COG1940	carbohydrate kinase activity
E3N83_RS04450	COG2188	Transcriptional regulator
E3N83_RS04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3N83_RS04470	COG3718	enzyme involved in inositol metabolism
E3N83_RS04475	COG3962	Belongs to the TPP enzyme family
E3N83_RS04480	COG1879	ABC-type sugar transport system periplasmic component
E3N83_RS04500	COG0673	inositol 2-dehydrogenase activity
E3N83_RS04515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E3N83_RS04520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E3N83_RS04545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E3N83_RS04550	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS04550	COG0204	Acyl-transferase
E3N83_RS04555	COG1160	GTP binding
E3N83_RS04570	COG1764	response to oxidative stress
E3N83_RS04600	COG5607	PFAM CHAD domain containing protein
E3N83_RS04600	COG3025	triphosphatase activity
E3N83_RS04605	COG0235	Class ii aldolase
E3N83_RS04635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3N83_RS04640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS04655	COG0477	Major facilitator Superfamily
E3N83_RS04670	COG1252	NADH dehydrogenase
E3N83_RS04685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3N83_RS04690	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3N83_RS04695	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3N83_RS04700	COG0493	'glutamate synthase
E3N83_RS04720	COG0596	Alpha beta hydrolase
E3N83_RS04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS04740	COG2318	DinB family
E3N83_RS04745	COG0517	IMP dehydrogenase activity
E3N83_RS04770	COG0463	Glycosyl transferase, family 2
E3N83_RS04785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3N83_RS04790	COG2197	response regulator
E3N83_RS04815	COG0243	molybdopterin cofactor binding
E3N83_RS04820	COG3383	formate dehydrogenase (NAD+) activity
E3N83_RS04820	COG0243	molybdopterin cofactor binding
E3N83_RS04825	COG0437	4 iron, 4 sulfur cluster binding
E3N83_RS04845	COG0783	Belongs to the Dps family
E3N83_RS04895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E3N83_RS04900	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E3N83_RS04905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E3N83_RS04920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3N83_RS04935	COG1253	flavin adenine dinucleotide binding
E3N83_RS04970	COG1716	ATPase activity
E3N83_RS04990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3N83_RS04990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E3N83_RS05005	COG0419	ATPase involved in DNA repair
E3N83_RS05010	COG0420	3'-5' exonuclease activity
E3N83_RS05015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3N83_RS05045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3N83_RS05050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3N83_RS05095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E3N83_RS05120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3N83_RS05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3N83_RS05150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3N83_RS05165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3N83_RS05185	COG1216	Glycosyl transferase, family 2
E3N83_RS05195	COG1607	acyl-coa hydrolase
E3N83_RS05200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS05205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E3N83_RS05230	COG1522	sequence-specific DNA binding
E3N83_RS05235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3N83_RS05255	COG0805	protein transport
E3N83_RS05280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E3N83_RS05290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E3N83_RS05295	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E3N83_RS05305	COG4122	O-methyltransferase activity
E3N83_RS05315	COG2226	methyltransferase
E3N83_RS05320	COG1222	aaa ATPase
E3N83_RS05340	COG2197	response regulator
E3N83_RS05360	COG0444	Belongs to the ABC transporter superfamily
E3N83_RS05370	COG0601	transmembrane transport
E3N83_RS05415	COG0598	Magnesium transport protein CorA
E3N83_RS05420	COG1968	undecaprenyl-diphosphatase activity
E3N83_RS05425	COG0667	Aldo Keto reductase
E3N83_RS05435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3N83_RS05460	COG0583	DNA-binding transcription factor activity
E3N83_RS05465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3N83_RS05485	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS05490	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS05495	COG0242	peptide deformylase activity
E3N83_RS05505	COG1648	precorrin-2 dehydrogenase activity
E3N83_RS05505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3N83_RS05510	COG1881	PFAM PEBP family protein
E3N83_RS05530	COG4555	ABC transporter
E3N83_RS05540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E3N83_RS05550	COG3588	fructose-bisphosphate aldolase
E3N83_RS05580	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS05585	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS05590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3N83_RS05615	COG1119	ATPase activity
E3N83_RS05625	COG3152	Membrane
E3N83_RS05635	COG0560	Phosphoserine phosphatase
E3N83_RS05635	COG3830	Belongs to the UPF0237 family
E3N83_RS05640	COG2062	phosphohistidine phosphatase, SixA
E3N83_RS05645	COG4242	Belongs to the peptidase S51 family
E3N83_RS05650	COG0189	ligase activity
E3N83_RS05650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3N83_RS05660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3N83_RS05680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3N83_RS05680	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3N83_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS05695	COG3360	Dodecin
E3N83_RS05705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E3N83_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS05720	COG1132	(ABC) transporter
E3N83_RS05725	COG1024	Enoyl-CoA hydratase
E3N83_RS05730	COG0488	(ABC) transporter
E3N83_RS05745	COG3559	Exporter of polyketide antibiotics
E3N83_RS05750	COG1131	(ABC) transporter
E3N83_RS05775	COG2151	metal-sulfur cluster biosynthetic enzyme
E3N83_RS05780	COG0822	iron-sulfur transferase activity
E3N83_RS05785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3N83_RS05790	COG0396	ATPase activity
E3N83_RS05830	COG1131	(ABC) transporter
E3N83_RS05840	COG1612	heme a metabolic process
E3N83_RS05845	COG0109	protoheme IX farnesyltransferase activity
E3N83_RS05855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E3N83_RS05860	COG0166	Belongs to the GPI family
E3N83_RS05875	COG0363	glucosamine-6-phosphate deaminase activity
E3N83_RS05890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3N83_RS05905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3N83_RS05910	COG1481	regulation of sporulation
E3N83_RS05920	COG1660	Displays ATPase and GTPase activities
E3N83_RS05925	COG0322	excinuclease ABC activity
E3N83_RS05935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3N83_RS05955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3N83_RS05985	COG1940	carbohydrate kinase activity
E3N83_RS05990	COG4214	carbohydrate transport
E3N83_RS06000	COG4213	ABC transporter substrate-binding protein
E3N83_RS06010	COG1070	Carbohydrate kinase
E3N83_RS06030	COG0657	acetylesterase activity
E3N83_RS06045	COG2226	methyltransferase
E3N83_RS06055	COG0492	ferredoxin-NADP+ reductase activity
E3N83_RS06095	COG0556	nucleotide-excision repair
E3N83_RS06115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3N83_RS06130	COG3483	tryptophan 2,3-dioxygenase activity
E3N83_RS06135	COG1793	dna ligase
E3N83_RS06160	COG0183	Belongs to the thiolase family
E3N83_RS06175	COG1946	Acyl-CoA thioesterase
E3N83_RS06200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E3N83_RS06235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3N83_RS06240	COG2086	electron transfer activity
E3N83_RS06255	COG4176	ABC-type proline glycine betaine transport system permease component
E3N83_RS06260	COG4175	Glycine betaine
E3N83_RS06260	COG0517	IMP dehydrogenase activity
E3N83_RS06270	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS06275	COG1414	Transcriptional regulator
E3N83_RS06285	COG5598	trimethylamine methyltransferase
E3N83_RS06295	COG5012	cobalamin binding
E3N83_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS06350	COG4638	Rieske (2fe-2S)
E3N83_RS06355	COG4608	Belongs to the ABC transporter superfamily
E3N83_RS06365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3N83_RS06370	COG0601	transmembrane transport
E3N83_RS06385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3N83_RS06390	COG2755	lipolytic protein G-D-S-L family
E3N83_RS06425	COG1595	DNA-templated transcription, initiation
E3N83_RS06445	COG0432	Pfam Uncharacterised protein family UPF0047
E3N83_RS06455	COG1131	(ABC) transporter
E3N83_RS06470	COG1595	DNA-templated transcription, initiation
E3N83_RS06480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3N83_RS06500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3N83_RS06505	COG0531	amino acid
E3N83_RS06510	COG0569	domain protein
E3N83_RS06535	COG0756	dUTP diphosphatase activity
E3N83_RS06560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E3N83_RS06595	COG1435	thymidine kinase activity
E3N83_RS06640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3N83_RS06640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3N83_RS06650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3N83_RS06660	COG0477	Major facilitator Superfamily
E3N83_RS06670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS06670	COG1672	PFAM Archaeal ATPase
E3N83_RS06690	COG0187	DNA topoisomerase II activity
E3N83_RS06720	COG1366	Belongs to the anti-sigma-factor antagonist family
E3N83_RS06760	COG1131	(ABC) transporter
E3N83_RS06815	COG1136	(ABC) transporter
E3N83_RS06825	COG0745	RESPONSE REGULATOR receiver
E3N83_RS06840	COG2890	protein-(glutamine-N5) methyltransferase activity
E3N83_RS06895	COG2318	DinB family
E3N83_RS06935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3N83_RS06950	COG0589	response to stress
E3N83_RS06970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3N83_RS06975	COG1984	allophanate hydrolase subunit 2
E3N83_RS06980	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3N83_RS06985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E3N83_RS07000	COG0237	dephospho-CoA kinase activity
E3N83_RS07015	COG0539	negative regulation of cytoplasmic translation
E3N83_RS07025	COG2226	methyltransferase
E3N83_RS07045	COG4981	capsule polysaccharide biosynthetic process
E3N83_RS07060	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS07085	COG2050	protein possibly involved in aromatic compounds catabolism
E3N83_RS07105	COG0667	Aldo Keto reductase
E3N83_RS07120	COG0559	Belongs to the binding-protein-dependent transport system permease family
E3N83_RS07175	COG0067	glutamate synthase
E3N83_RS07175	COG0070	glutamate synthase
E3N83_RS07175	COG0069	glutamate synthase activity
E3N83_RS07185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E3N83_RS07195	COG0159	tryptophan synthase activity
E3N83_RS07200	COG0133	tryptophan synthase activity
E3N83_RS07205	COG0134	indole-3-glycerol-phosphate synthase activity
E3N83_RS07225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3N83_RS07235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3N83_RS07245	COG2318	DinB family
E3N83_RS07260	COG0107	imidazoleglycerol-phosphate synthase activity
E3N83_RS07265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E3N83_RS07270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3N83_RS07280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E3N83_RS07285	COG0131	Imidazoleglycerol-phosphate dehydratase
E3N83_RS07290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3N83_RS07315	COG0587	DNA-directed DNA polymerase activity
E3N83_RS07335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E3N83_RS07340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3N83_RS07350	COG1799	cell septum assembly
E3N83_RS07360	COG1496	oxidoreductase activity
E3N83_RS07365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3N83_RS07370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3N83_RS07375	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E3N83_RS07380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3N83_RS07390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3N83_RS07395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3N83_RS07400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3N83_RS07405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E3N83_RS07410	COG0768	penicillin binding
E3N83_RS07420	COG0275	rRNA processing
E3N83_RS07430	COG2001	Belongs to the MraZ family
E3N83_RS07435	COG0714	Associated with various cellular activities
E3N83_RS07455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3N83_RS07460	COG2226	methyltransferase
E3N83_RS07465	COG0587	DNA-directed DNA polymerase activity
E3N83_RS07515	COG1233	COG1233 Phytoene dehydrogenase and related
E3N83_RS07525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3N83_RS07530	COG0142	geranyltranstransferase activity
E3N83_RS07565	COG2815	serine threonine protein kinase
E3N83_RS07565	COG0515	serine threonine protein kinase
E3N83_RS07600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E3N83_RS07615	COG0205	6-phosphofructokinase activity
E3N83_RS07635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E3N83_RS07650	COG2197	response regulator
E3N83_RS07690	COG1940	carbohydrate kinase activity
E3N83_RS07700	COG0003	Pfam Anion-transporting ATPase
E3N83_RS07765	COG0501	Belongs to the peptidase M48B family
E3N83_RS07805	COG0673	inositol 2-dehydrogenase activity
E3N83_RS07835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3N83_RS07835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3N83_RS07840	COG1022	Amp-dependent synthetase and ligase
E3N83_RS07880	COG0481	GTPase activity
E3N83_RS07915	COG0028	Belongs to the TPP enzyme family
E3N83_RS07920	COG0069	glutamate synthase activity
E3N83_RS07935	COG0268	Binds directly to 16S ribosomal RNA
E3N83_RS07945	COG2333	competence protein COMEC
E3N83_RS07945	COG0658	competence protein
E3N83_RS07950	COG1555	photosystem II stabilization
E3N83_RS07955	COG1307	EDD domain protein, DegV family
E3N83_RS07960	COG0495	leucyl-tRNA aminoacylation
E3N83_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS07990	COG0702	epimerase
E3N83_RS08010	COG0799	negative regulation of ribosome biogenesis
E3N83_RS08015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E3N83_RS08020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E3N83_RS08025	COG0175	sulfate reduction
E3N83_RS08035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3N83_RS08065	COG0058	SHG alpha-glucan phosphorylase activity
E3N83_RS08070	COG0366	Alpha amylase catalytic
E3N83_RS08080	COG3281	Trehalose synthase
E3N83_RS08085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E3N83_RS08100	COG0574	Belongs to the PEP-utilizing enzyme family
E3N83_RS08100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3N83_RS08105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS08115	COG0427	acetyl-CoA hydrolase
E3N83_RS08120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS08120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS08125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3N83_RS08140	COG1846	Transcriptional regulator
E3N83_RS08150	COG0183	Belongs to the thiolase family
E3N83_RS08155	COG0346	lactoylglutathione lyase activity
E3N83_RS08170	COG0628	permease
E3N83_RS08175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3N83_RS08180	COG2169	Transcriptional regulator
E3N83_RS08180	COG1917	Cupin 2, conserved barrel domain protein
E3N83_RS08215	COG4948	Mandelate Racemase Muconate Lactonizing
E3N83_RS08235	COG3119	arylsulfatase activity
E3N83_RS08245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3N83_RS08250	COG0601	transmembrane transport
E3N83_RS08270	COG3246	L-lysine catabolic process to acetate
E3N83_RS08275	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3N83_RS08280	COG0824	Thioesterase
E3N83_RS08280	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3N83_RS08290	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS08300	COG1024	Enoyl-CoA hydratase
E3N83_RS08325	COG0596	Alpha beta hydrolase
E3N83_RS08360	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3N83_RS08375	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E3N83_RS08395	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E3N83_RS08420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS08420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS08440	COG0328	RNA-DNA hybrid ribonuclease activity
E3N83_RS08445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3N83_RS08450	COG3903	Transcriptional regulator
E3N83_RS08450	COG3629	intracellular signal transduction
E3N83_RS08460	COG0738	Major facilitator superfamily
E3N83_RS08470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E3N83_RS08475	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E3N83_RS08480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E3N83_RS08485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E3N83_RS08490	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3N83_RS08495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E3N83_RS08500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3N83_RS08505	COG0356	it plays a direct role in the translocation of protons across the membrane
E3N83_RS08530	COG2890	protein-(glutamine-N5) methyltransferase activity
E3N83_RS08535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3N83_RS08540	COG0254	rRNA binding
E3N83_RS08555	COG3794	PFAM blue (type 1) copper domain protein
E3N83_RS08565	COG0083	homoserine kinase activity
E3N83_RS08570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3N83_RS08575	COG0460	homoserine dehydrogenase
E3N83_RS08580	COG0019	diaminopimelate decarboxylase activity
E3N83_RS08585	COG0018	arginyl-trna synthetase
E3N83_RS08600	COG2366	antibiotic biosynthetic process
E3N83_RS08615	COG1316	TRANSCRIPTIONal
E3N83_RS08625	COG0567	Dehydrogenase, E1 component
E3N83_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS08645	COG0604	alcohol dehydrogenase
E3N83_RS08665	COG2172	sigma factor antagonist activity
E3N83_RS08670	COG1191	sigma factor activity
E3N83_RS08710	COG5662	AntiSigma factor
E3N83_RS08725	COG2135	peptidase activity
E3N83_RS08745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E3N83_RS08750	COG1162	GTPase activity
E3N83_RS08780	COG2501	S4 domain
E3N83_RS08785	COG2733	membrane
E3N83_RS08790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3N83_RS08805	COG0601	transmembrane transport
E3N83_RS08815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E3N83_RS08820	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E3N83_RS08830	COG4608	Belongs to the ABC transporter superfamily
E3N83_RS08845	COG0601	transmembrane transport
E3N83_RS08850	COG4166	transmembrane transport
E3N83_RS08865	COG2226	methyltransferase
E3N83_RS08875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3N83_RS08885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3N83_RS08895	COG1234	tRNA 3'-trailer cleavage
E3N83_RS08925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3N83_RS08930	COG0662	Cupin 2, conserved barrel domain protein
E3N83_RS08930	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E3N83_RS08940	COG0071	Belongs to the small heat shock protein (HSP20) family
E3N83_RS08945	COG0789	Transcriptional regulator
E3N83_RS08960	COG3383	formate dehydrogenase (NAD+) activity
E3N83_RS08970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3N83_RS09000	COG1140	nitrate reductase beta subunit
E3N83_RS09025	COG2197	response regulator
E3N83_RS09030	COG4585	Histidine kinase
E3N83_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS09085	COG0028	Belongs to the TPP enzyme family
E3N83_RS09105	COG1846	Transcriptional regulator
E3N83_RS09110	COG3387	PFAM Glycoside hydrolase 15-related
E3N83_RS09115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3N83_RS09120	COG2017	converts alpha-aldose to the beta-anomer
E3N83_RS09130	COG4585	Histidine kinase
E3N83_RS09135	COG2197	response regulator
E3N83_RS09140	COG2197	response regulator
E3N83_RS09145	COG4585	Histidine kinase
E3N83_RS09230	COG4689	acetoacetate decarboxylase
E3N83_RS09235	COG0174	glutamine synthetase
E3N83_RS09240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3N83_RS09240	COG0519	Catalyzes the synthesis of GMP from XMP
E3N83_RS09245	COG1846	Transcriptional regulator
E3N83_RS09250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3N83_RS09265	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3N83_RS09280	COG0076	glutamate decarboxylase activity
E3N83_RS09330	COG1615	UPF0182 protein
E3N83_RS09340	COG3480	Lon protease (S16) C-terminal proteolytic domain
E3N83_RS09410	COG2816	NAD+ diphosphatase activity
E3N83_RS09415	COG0463	Glycosyl transferase, family 2
E3N83_RS09420	COG0813	purine-nucleoside phosphorylase activity
E3N83_RS09430	COG0210	DNA helicase
E3N83_RS09450	COG0549	Belongs to the carbamate kinase family
E3N83_RS09480	COG0673	inositol 2-dehydrogenase activity
E3N83_RS09485	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS09485	COG0204	Acyl-transferase
E3N83_RS09495	COG0154	amidase activity
E3N83_RS09520	COG2233	PERMEase
E3N83_RS09530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3N83_RS09535	COG1304	FMN binding
E3N83_RS09555	COG0714	Associated with various cellular activities
E3N83_RS09605	COG0513	Belongs to the DEAD box helicase family
E3N83_RS09615	COG1192	Involved in chromosome partitioning
E3N83_RS09620	COG0300	oxidoreductase activity
E3N83_RS09630	COG2095	MarC family integral membrane protein
E3N83_RS09645	COG2235	arginine
E3N83_RS09660	COG0406	alpha-ribazole phosphatase activity
E3N83_RS09680	COG0393	Putative heavy-metal-binding
E3N83_RS09695	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS09740	COG3119	arylsulfatase activity
E3N83_RS09745	COG2239	Acts as a magnesium transporter
E3N83_RS09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3N83_RS09780	COG0653	protein targeting
E3N83_RS09785	COG3214	Protein conserved in bacteria
E3N83_RS09790	COG2132	Multicopper oxidase
E3N83_RS09795	COG2197	response regulator
E3N83_RS09800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3N83_RS09815	COG5002	protein histidine kinase activity
E3N83_RS09820	COG0745	RESPONSE REGULATOR receiver
E3N83_RS09825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E3N83_RS09845	COG2835	tetraacyldisaccharide 4'-kinase activity
E3N83_RS09875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3N83_RS09880	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E3N83_RS09880	COG0778	Nitroreductase
E3N83_RS09905	COG1216	Glycosyl transferase, family 2
E3N83_RS09920	COG1216	Glycosyl transferase, family 2
E3N83_RS09925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3N83_RS09930	COG1819	glycosyl
E3N83_RS09950	COG2040	homocysteine
E3N83_RS09970	COG1316	TRANSCRIPTIONal
E3N83_RS09990	COG2050	protein possibly involved in aromatic compounds catabolism
E3N83_RS09995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3N83_RS10010	COG2271	Major facilitator Superfamily
E3N83_RS10020	COG0693	protein deglycase activity
E3N83_RS10040	COG0431	NADPH-dependent FMN reductase
E3N83_RS10050	COG0583	DNA-binding transcription factor activity
E3N83_RS10055	COG1968	undecaprenyl-diphosphatase activity
E3N83_RS10095	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS10100	COG1832	CoA-binding protein
E3N83_RS10105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3N83_RS10110	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3N83_RS10115	COG4585	Histidine kinase
E3N83_RS10120	COG2197	response regulator
E3N83_RS10140	COG0745	RESPONSE REGULATOR receiver
E3N83_RS10145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS10160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3N83_RS10205	COG2226	methyltransferase
E3N83_RS10210	COG0424	maF-like protein
E3N83_RS10225	COG0477	Major facilitator Superfamily
E3N83_RS10230	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS10235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3N83_RS10245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3N83_RS10255	COG0277	FAD linked oxidase domain protein
E3N83_RS10275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3N83_RS10280	COG4770	biotin carboxylase activity
E3N83_RS10300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E3N83_RS10305	COG2247	cell wall binding repeat
E3N83_RS10305	COG2385	sporulation resulting in formation of a cellular spore
E3N83_RS10345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3N83_RS10355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E3N83_RS10360	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS10365	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS10385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3N83_RS10410	COG1079	Belongs to the binding-protein-dependent transport system permease family
E3N83_RS10415	COG4603	Belongs to the binding-protein-dependent transport system permease family
E3N83_RS10420	COG3845	ABC transporter
E3N83_RS10425	COG1744	ABC transporter substrate-binding protein PnrA-like
E3N83_RS10430	COG1473	amidohydrolase
E3N83_RS10430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E3N83_RS10460	COG1053	succinate dehydrogenase
E3N83_RS10470	COG1295	ribonuclease BN
E3N83_RS10480	COG0180	Tryptophanyl-tRNA synthetase
E3N83_RS10495	COG2814	Major facilitator Superfamily
E3N83_RS10500	COG2838	Isocitrate dehydrogenase
E3N83_RS10515	COG0039	L-malate dehydrogenase activity
E3N83_RS10525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E3N83_RS10530	COG0138	bifunctional purine biosynthesis protein purh
E3N83_RS10560	COG0045	succinate-CoA ligase (ADP-forming) activity
E3N83_RS10565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3N83_RS10570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS10570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E3N83_RS10575	COG0741	lytic transglycosylase activity
E3N83_RS10575	COG0739	heme binding
E3N83_RS10575	COG1196	nuclear chromosome segregation
E3N83_RS10590	COG2197	response regulator
E3N83_RS10630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS10650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS10650	COG1672	PFAM Archaeal ATPase
E3N83_RS10655	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS10670	COG1366	Belongs to the anti-sigma-factor antagonist family
E3N83_RS10675	COG0596	Alpha beta hydrolase
E3N83_RS10680	COG2770	Histidine kinase
E3N83_RS10680	COG2208	phosphoserine phosphatase activity
E3N83_RS10685	COG2409	Drug exporters of the RND superfamily
E3N83_RS10690	COG2124	cytochrome p450
E3N83_RS10695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3N83_RS10695	COG0617	tRNA 3'-terminal CCA addition
E3N83_RS10695	COG0517	IMP dehydrogenase activity
E3N83_RS10720	COG2072	flavoprotein involved in K transport
E3N83_RS10725	COG3321	synthase
E3N83_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS10725	COG0604	alcohol dehydrogenase
E3N83_RS10735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E3N83_RS10735	COG0519	Catalyzes the synthesis of GMP from XMP
E3N83_RS10745	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS10750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3N83_RS10760	COG3173	Aminoglycoside phosphotransferase
E3N83_RS10765	COG2197	response regulator
E3N83_RS10770	COG0516	GMP reductase activity
E3N83_RS10795	COG0459	protein refolding
E3N83_RS10800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3N83_RS10810	COG0477	Major facilitator Superfamily
E3N83_RS10830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3N83_RS10855	COG1595	DNA-templated transcription, initiation
E3N83_RS10870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3N83_RS10880	COG1214	PFAM Peptidase M22, glycoprotease
E3N83_RS10880	COG0456	acetyltransferase
E3N83_RS10885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3N83_RS10895	COG0802	atpase or kinase
E3N83_RS10905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3N83_RS10915	COG0736	holo-[acyl-carrier-protein] synthase activity
E3N83_RS10920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3N83_RS10925	COG1072	(Pantothenic acid kinase))
E3N83_RS10935	COG0366	Alpha amylase catalytic
E3N83_RS10955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3N83_RS10960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E3N83_RS10965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E3N83_RS10975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3N83_RS10980	COG0372	Belongs to the citrate synthase family
E3N83_RS10995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3N83_RS11025	COG0488	(ABC) transporter
E3N83_RS11045	COG0577	efflux transmembrane transporter activity
E3N83_RS11045	COG1136	(ABC) transporter
E3N83_RS11110	COG1793	dna ligase
E3N83_RS11130	COG1442	glycosyl transferase family 8
E3N83_RS11130	COG1216	Glycosyl transferase, family 2
E3N83_RS11135	COG1472	Belongs to the glycosyl hydrolase 3 family
E3N83_RS11160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3N83_RS11165	COG3253	May function as heme-dependent peroxidase
E3N83_RS11180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E3N83_RS11190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E3N83_RS11205	COG1643	Atp-dependent helicase
E3N83_RS11225	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3N83_RS11250	COG0745	RESPONSE REGULATOR receiver
E3N83_RS11255	COG2205	protein histidine kinase activity
E3N83_RS11260	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3N83_RS11265	COG1309	transcriptional regulator
E3N83_RS11270	COG2072	flavoprotein involved in K transport
E3N83_RS11290	COG4129	membrane
E3N83_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS11335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3N83_RS11340	COG0297	glycogen (starch) synthase activity
E3N83_RS11365	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS11370	COG1024	Enoyl-CoA hydratase
E3N83_RS11430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS11465	COG1397	ADP-ribosylglycohydrolase
E3N83_RS11510	COG0431	NADPH-dependent FMN reductase
E3N83_RS11520	COG0778	Nitroreductase
E3N83_RS11530	COG4941	Belongs to the sigma-70 factor family
E3N83_RS11535	COG3795	YCII-related domain
E3N83_RS11550	COG4733	cellulase activity
E3N83_RS11550	COG5297	Belongs to the glycosyl hydrolase family 6
E3N83_RS11570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3N83_RS11575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E3N83_RS11600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E3N83_RS11620	COG0745	RESPONSE REGULATOR receiver
E3N83_RS11625	COG2205	protein histidine kinase activity
E3N83_RS11650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E3N83_RS11665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3N83_RS11680	COG1063	alcohol dehydrogenase
E3N83_RS11710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E3N83_RS11720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E3N83_RS11750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3N83_RS11765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3N83_RS11775	COG1937	Protein conserved in bacteria
E3N83_RS11790	COG4106	trans-aconitate 2-methyltransferase activity
E3N83_RS11800	COG0488	(ABC) transporter
E3N83_RS11805	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E3N83_RS11810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3N83_RS11815	COG3583	domain protein
E3N83_RS11820	COG0084	hydrolase, TatD family'
E3N83_RS11840	COG0667	Aldo Keto reductase
E3N83_RS11845	COG0251	oxidation-reduction process
E3N83_RS11880	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3N83_RS11885	COG0315	cyclic pyranopterin monophosphate synthase activity
E3N83_RS11905	COG2827	Endonuclease containing a URI domain
E3N83_RS11925	COG1970	mechanosensitive ion channel activity
E3N83_RS11955	COG3268	Saccharopine dehydrogenase
E3N83_RS11985	COG0366	Alpha amylase catalytic
E3N83_RS11990	COG1846	Transcriptional regulator
E3N83_RS12025	COG0259	pyridoxamine-phosphate oxidase activity
E3N83_RS12035	COG2226	methyltransferase
E3N83_RS12050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3N83_RS12095	COG0644	oxidoreductase
E3N83_RS12105	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E3N83_RS12110	COG0085	RNA polymerase activity
E3N83_RS12115	COG0484	heat shock protein binding
E3N83_RS12155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3N83_RS12160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E3N83_RS12170	COG0222	ribosome binding
E3N83_RS12175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E3N83_RS12180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3N83_RS12185	COG0081	regulation of translation
E3N83_RS12190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3N83_RS12195	COG0250	Participates in transcription elongation, termination and antitermination
E3N83_RS12210	COG0436	Aminotransferase
E3N83_RS12215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E3N83_RS12225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E3N83_RS12235	COG2030	dehydratase
E3N83_RS12240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3N83_RS12265	COG0154	amidase activity
E3N83_RS12270	COG0519	Catalyzes the synthesis of GMP from XMP
E3N83_RS12285	COG1132	(ABC) transporter
E3N83_RS12290	COG1132	(ABC) transporter
E3N83_RS12305	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3N83_RS12315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3N83_RS12320	COG3842	ATPase activity
E3N83_RS12325	COG4106	trans-aconitate 2-methyltransferase activity
E3N83_RS12375	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS12375	COG1672	PFAM Archaeal ATPase
E3N83_RS12390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E3N83_RS12410	COG1666	GTP binding
E3N83_RS12435	COG3842	ATPase activity
E3N83_RS12440	COG4208	sulfate ABC transporter
E3N83_RS12450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E3N83_RS12455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E3N83_RS12455	COG0674	pyruvate-flavodoxin oxidoreductase activity
E3N83_RS12460	COG1013	pyruvate-flavodoxin oxidoreductase activity
E3N83_RS12475	COG0142	geranyltranstransferase activity
E3N83_RS12480	COG1007	ATP synthesis coupled electron transport
E3N83_RS12490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3N83_RS12495	COG0713	ATP synthesis coupled electron transport
E3N83_RS12505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3N83_RS12510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E3N83_RS12515	COG1034	ATP synthesis coupled electron transport
E3N83_RS12530	COG0649	NAD binding
E3N83_RS12535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3N83_RS12540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E3N83_RS12550	COG2226	methyltransferase
E3N83_RS12565	COG1169	isochorismate synthase
E3N83_RS12570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E3N83_RS12580	COG2207	Transcriptional regulator
E3N83_RS12585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E3N83_RS12590	COG4948	Mandelate Racemase Muconate Lactonizing
E3N83_RS12620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3N83_RS12630	COG0785	Cytochrome C biogenesis protein
E3N83_RS12640	COG0406	alpha-ribazole phosphatase activity
E3N83_RS12645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3N83_RS12655	COG0113	porphobilinogen synthase activity
E3N83_RS12660	COG1648	precorrin-2 dehydrogenase activity
E3N83_RS12660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3N83_RS12670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E3N83_RS12675	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E3N83_RS12685	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS12695	COG1595	DNA-templated transcription, initiation
E3N83_RS12725	COG0123	including yeast histone deacetylase and acetoin utilization protein
E3N83_RS12730	COG0180	Tryptophanyl-tRNA synthetase
E3N83_RS12735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3N83_RS12740	COG0506	proline dehydrogenase activity
E3N83_RS12755	COG1129	ABC transporter
E3N83_RS12755	COG0842	Transport permease protein
E3N83_RS12765	COG1082	Xylose isomerase domain protein TIM barrel
E3N83_RS12770	COG0248	Ppx GppA phosphatase
E3N83_RS12785	COG2226	methyltransferase
E3N83_RS12790	COG1609	Transcriptional regulator
E3N83_RS12795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3N83_RS12800	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E3N83_RS12820	COG2076	Multidrug Resistance protein
E3N83_RS12835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E3N83_RS12845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3N83_RS12850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E3N83_RS12890	COG0463	Glycosyl transferase, family 2
E3N83_RS12890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3N83_RS12890	COG0463	Glycosyl transferase, family 2
E3N83_RS12890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3N83_RS12900	COG1216	Glycosyl transferase, family 2
E3N83_RS12910	COG1174	glycine betaine transport
E3N83_RS12915	COG1174	glycine betaine transport
E3N83_RS12920	COG0517	IMP dehydrogenase activity
E3N83_RS12920	COG1125	glycine betaine transport
E3N83_RS12935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3N83_RS12940	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3N83_RS12945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3N83_RS12950	COG0302	gtp cyclohydrolase
E3N83_RS12995	COG0037	tRNA processing
E3N83_RS13005	COG2027	D-alanyl-D-alanine carboxypeptidase
E3N83_RS13010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E3N83_RS13045	COG3842	ATPase activity
E3N83_RS13050	COG2011	ABC-type metal ion transport system permease component
E3N83_RS13055	COG4143	(ABC) transporter
E3N83_RS13070	COG0390	transport system, permease component
E3N83_RS13080	COG0477	Major facilitator Superfamily
E3N83_RS13085	COG1309	transcriptional regulator
E3N83_RS13120	COG1672	PFAM Archaeal ATPase
E3N83_RS13120	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS13140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3N83_RS13145	COG0387	Pfam Sodium calcium exchanger
E3N83_RS13160	COG1754	DNA topoisomerase type I activity
E3N83_RS13160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3N83_RS13165	COG2890	protein-(glutamine-N5) methyltransferase activity
E3N83_RS13175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E3N83_RS13180	COG1366	Belongs to the anti-sigma-factor antagonist family
E3N83_RS13185	COG1111	helicase
E3N83_RS13185	COG1205	dead DEAH box helicase
E3N83_RS13245	COG1584	GPR1 FUN34 yaaH family protein
E3N83_RS13250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3N83_RS13255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E3N83_RS13270	COG0494	nUDIX hydrolase
E3N83_RS13275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3N83_RS13280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3N83_RS13355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3N83_RS13405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3N83_RS13410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3N83_RS13420	COG0569	domain protein
E3N83_RS13420	COG0475	glutathione-regulated potassium exporter activity
E3N83_RS13445	COG1595	DNA-templated transcription, initiation
E3N83_RS13455	COG1404	Belongs to the peptidase S8 family
E3N83_RS13495	COG1674	ftsk spoiiie
E3N83_RS13505	COG0433	COG0433 Predicted ATPase
E3N83_RS13515	COG3263	regulation of cellular component size
E3N83_RS13550	COG0542	response to heat
E3N83_RS13570	COG1024	Enoyl-CoA hydratase
E3N83_RS13585	COG0531	amino acid
E3N83_RS13595	COG0590	tRNA wobble adenosine to inosine editing
E3N83_RS13605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E3N83_RS13640	COG0277	FAD linked oxidase domain protein
E3N83_RS13675	COG0477	Major facilitator Superfamily
E3N83_RS13685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3N83_RS13695	COG3118	belongs to the thioredoxin family
E3N83_RS13715	COG1074	ATP-dependent DNA helicase activity
E3N83_RS13720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E3N83_RS13760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3N83_RS13775	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E3N83_RS13805	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E3N83_RS13815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3N83_RS13820	COG0746	molybdenum cofactor guanylyltransferase activity
E3N83_RS13845	COG0561	phosphatase activity
E3N83_RS13850	COG0561	phosphatase activity
E3N83_RS13855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E3N83_RS13885	COG0077	Prephenate dehydratase
E3N83_RS13885	COG1605	Chorismate mutase
E3N83_RS13900	COG2235	arginine
E3N83_RS13905	COG0653	protein targeting
E3N83_RS13930	COG0515	serine threonine protein kinase
E3N83_RS13945	COG2814	Major facilitator Superfamily
E3N83_RS13980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3N83_RS13985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3N83_RS13995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E3N83_RS14030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3N83_RS14050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3N83_RS14065	COG0477	Major facilitator Superfamily
E3N83_RS14070	COG3409	Peptidoglycan-binding domain 1 protein
E3N83_RS14075	COG2045	Belongs to the ComB family
E3N83_RS14080	COG3590	peptidase
E3N83_RS14095	COG0477	Major facilitator Superfamily
E3N83_RS14105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3N83_RS14115	COG0386	Belongs to the glutathione peroxidase family
E3N83_RS14145	COG0405	Gamma-glutamyltransferase
E3N83_RS14165	COG1716	ATPase activity
E3N83_RS14185	COG0768	penicillin binding
E3N83_RS14190	COG0515	serine threonine protein kinase
E3N83_RS14195	COG0515	serine threonine protein kinase
E3N83_RS14210	COG0457	Tetratricopeptide repeat
E3N83_RS14210	COG0705	Rhomboid family
E3N83_RS14215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3N83_RS14245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3N83_RS14250	COG0798	PFAM Bile acid sodium symporter
E3N83_RS14255	COG0640	Transcriptional regulator
E3N83_RS14285	COG1252	NADH dehydrogenase
E3N83_RS14320	COG1002	Type II restriction enzyme, methylase subunits
E3N83_RS14350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3N83_RS14355	COG0187	DNA topoisomerase II activity
E3N83_RS14365	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
E3N83_RS14370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E3N83_RS14375	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E3N83_RS14380	COG0592	DNA-directed DNA polymerase activity
E3N83_RS14390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E3N83_RS14395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3N83_RS14400	COG0594	ribonuclease P activity
E3N83_RS14410	COG0706	membrane insertase activity
E3N83_RS14420	COG0357	Ribosomal RNA small subunit methyltransferase G
E3N83_RS14425	COG1192	Involved in chromosome partitioning
E3N83_RS14430	COG1475	DNA binding
E3N83_RS14435	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS14435	COG0204	Acyl-transferase
E3N83_RS14450	COG3118	belongs to the thioredoxin family
E3N83_RS14455	COG0492	ferredoxin-NADP+ reductase activity
E3N83_RS14465	COG1595	DNA-templated transcription, initiation
E3N83_RS14485	COG0617	tRNA 3'-terminal CCA addition
E3N83_RS14495	COG5473	translation initiation factor activity
E3N83_RS14500	COG1260	myo-inositol-1-phosphate synthase
E3N83_RS14510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3N83_RS14520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3N83_RS14535	COG0515	serine threonine protein kinase
E3N83_RS14545	COG0360	Binds together with S18 to 16S ribosomal RNA
E3N83_RS14550	COG0629	single-stranded DNA binding
E3N83_RS14555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E3N83_RS14560	COG0359	binds to the 23S rRNA
E3N83_RS14575	COG0305	Participates in initiation and elongation during chromosome replication
E3N83_RS14595	COG0697	spore germination
E3N83_RS14600	COG0583	DNA-binding transcription factor activity
E3N83_RS14625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E3N83_RS14640	COG0702	epimerase
E3N83_RS14665	COG2267	carboxylic ester hydrolase activity
E3N83_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS14670	COG3321	synthase
E3N83_RS14670	COG0604	alcohol dehydrogenase
E3N83_RS14725	COG1937	Protein conserved in bacteria
E3N83_RS14730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E3N83_RS14745	COG0456	acetyltransferase
E3N83_RS14750	COG2353	YceI-like domain
E3N83_RS14755	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E3N83_RS14760	COG0768	penicillin binding
E3N83_RS14780	COG2197	response regulator
E3N83_RS14795	COG0277	FAD linked oxidase domain protein
E3N83_RS14815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3N83_RS14840	COG0765	amino acid transport
E3N83_RS14850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E3N83_RS14875	COG0702	epimerase
E3N83_RS14885	COG0183	Belongs to the thiolase family
E3N83_RS14890	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3N83_RS14890	COG1024	Enoyl-CoA hydratase
E3N83_RS14925	COG1131	(ABC) transporter
E3N83_RS14935	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS14975	COG0740	serine-type endopeptidase activity
E3N83_RS14980	COG0740	serine-type endopeptidase activity
E3N83_RS14995	COG1714	RDD family
E3N83_RS15005	COG1136	(ABC) transporter
E3N83_RS15005	COG0577	efflux transmembrane transporter activity
E3N83_RS15045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3N83_RS15080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3N83_RS15085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E3N83_RS15105	COG1024	Enoyl-CoA hydratase
E3N83_RS15160	COG2205	protein histidine kinase activity
E3N83_RS15165	COG0745	RESPONSE REGULATOR receiver
E3N83_RS15170	COG3001	Fructosamine kinase
E3N83_RS15180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3N83_RS15185	COG1950	PFAM Membrane protein of
E3N83_RS15190	COG2186	Transcriptional regulator
E3N83_RS15195	COG1834	amidinotransferase
E3N83_RS15210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E3N83_RS15235	COG0435	Glutathione S-transferase
E3N83_RS15245	COG0477	Major facilitator Superfamily
E3N83_RS15255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3N83_RS15270	COG1846	Transcriptional regulator
E3N83_RS15305	COG0022	dehydrogenase e1 component
E3N83_RS15310	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS15320	COG1595	DNA-templated transcription, initiation
E3N83_RS15340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E3N83_RS15345	COG2267	carboxylic ester hydrolase activity
E3N83_RS15370	COG2318	DinB family
E3N83_RS15380	COG0154	amidase activity
E3N83_RS15385	COG0513	Belongs to the DEAD box helicase family
E3N83_RS15405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E3N83_RS15430	COG1454	alcohol dehydrogenase
E3N83_RS15435	COG3485	protocatechuate 3,4-dioxygenase
E3N83_RS15455	COG3842	ATPase activity
E3N83_RS15465	COG1176	ABC-type spermidine putrescine transport system, permease component I
E3N83_RS15470	COG1177	transmembrane transport
E3N83_RS15475	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS15500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3N83_RS15540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3N83_RS15555	COG0535	radical SAM domain protein
E3N83_RS15595	COG1278	Cold shock
E3N83_RS15615	COG2815	serine threonine protein kinase
E3N83_RS15615	COG0515	serine threonine protein kinase
E3N83_RS15645	COG0531	amino acid
E3N83_RS15650	COG1414	Transcriptional regulator
E3N83_RS15655	COG0402	S-adenosylhomocysteine deaminase activity
E3N83_RS15695	COG2309	aminopeptidase activity
E3N83_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
E3N83_RS15780	COG1181	Belongs to the D-alanine--D-alanine ligase family
E3N83_RS15815	COG0513	Belongs to the DEAD box helicase family
E3N83_RS15830	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS15850	COG2755	lipolytic protein G-D-S-L family
E3N83_RS15855	COG0717	Belongs to the dCTP deaminase family
E3N83_RS15875	COG2181	nitrate reductase activity
E3N83_RS15875	COG0247	lactate metabolic process
E3N83_RS15900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E3N83_RS15915	COG0501	Belongs to the peptidase M48B family
E3N83_RS15930	COG2301	Belongs to the HpcH HpaI aldolase family
E3N83_RS15935	COG2301	Belongs to the HpcH HpaI aldolase family
E3N83_RS15980	COG0778	Nitroreductase
E3N83_RS15980	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E3N83_RS15995	COG1228	amidohydrolase
E3N83_RS16000	COG1672	PFAM Archaeal ATPase
E3N83_RS16000	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E3N83_RS16030	COG0697	spore germination
E3N83_RS16050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3N83_RS16065	COG1247	-acetyltransferase
E3N83_RS16070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E3N83_RS16085	COG0443	Heat shock 70 kDa protein
E3N83_RS16090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E3N83_RS16095	COG0484	heat shock protein binding
E3N83_RS16100	COG0789	Transcriptional regulator
E3N83_RS16105	COG1404	Belongs to the peptidase S8 family
E3N83_RS16110	COG1357	PFAM Pentapeptide repeats (8 copies)
E3N83_RS16115	COG0542	response to heat
E3N83_RS16120	COG0667	Aldo Keto reductase
E3N83_RS16140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3N83_RS16150	COG0586	Pfam SNARE associated Golgi protein
E3N83_RS16170	COG0191	fructose-bisphosphate aldolase activity
E3N83_RS16185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E3N83_RS16200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E3N83_RS16205	COG0753	catalase activity
E3N83_RS16225	COG0151	Belongs to the GarS family
E3N83_RS16235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3N83_RS16245	COG1254	Belongs to the acylphosphatase family
E3N83_RS16250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3N83_RS16265	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3N83_RS16270	COG0047	phosphoribosylformylglycinamidine synthase activity
E3N83_RS16295	COG2226	methyltransferase
E3N83_RS16305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3N83_RS16315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E3N83_RS16345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3N83_RS16360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E3N83_RS16380	COG1595	DNA-templated transcription, initiation
E3N83_RS16430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3N83_RS16465	COG0183	Belongs to the thiolase family
E3N83_RS16475	COG0673	inositol 2-dehydrogenase activity
E3N83_RS16495	COG1278	Cold shock
E3N83_RS16505	COG0494	nUDIX hydrolase
E3N83_RS16505	COG0406	alpha-ribazole phosphatase activity
E3N83_RS16525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3N83_RS16535	COG0306	phosphate transporter
E3N83_RS16545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E3N83_RS16550	COG0657	acetylesterase activity
E3N83_RS16560	COG4044	May play a role in the intracellular transport of hydrophobic ligands
E3N83_RS16570	COG0354	folic acid binding
E3N83_RS16575	COG0456	acetyltransferase
E3N83_RS16575	COG0454	-acetyltransferase
E3N83_RS16580	COG0745	RESPONSE REGULATOR receiver
E3N83_RS16595	COG0745	RESPONSE REGULATOR receiver
E3N83_RS16600	COG2205	protein histidine kinase activity
E3N83_RS16630	COG1490	D-aminoacyl-tRNA deacylase activity
E3N83_RS16635	COG3246	L-lysine catabolic process to acetate
E3N83_RS16640	COG0489	protein tyrosine kinase activity
E3N83_RS16640	COG3206	protein involved in exopolysaccharide biosynthesis
E3N83_RS16680	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E3N83_RS16685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3N83_RS16700	COG1086	Polysaccharide biosynthesis protein
E3N83_RS16705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3N83_RS16755	COG0535	radical SAM domain protein
E3N83_RS16765	COG0730	response to heat
E3N83_RS16770	COG0730	response to heat
E3N83_RS16800	COG1086	Polysaccharide biosynthesis protein
E3N83_RS16815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3N83_RS16835	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3N83_RS16865	COG1217	gtp-binding protein TYPA
E3N83_RS16875	COG1132	(ABC) transporter
E3N83_RS16885	COG1794	racemase activity, acting on amino acids and derivatives
E3N83_RS16900	COG0438	transferase activity, transferring glycosyl groups
E3N83_RS16925	COG0247	lactate metabolic process
E3N83_RS16930	COG1139	Iron-sulfur cluster binding protein
E3N83_RS16935	COG1556	Lactate utilization protein
E3N83_RS16955	COG2409	Drug exporters of the RND superfamily
E3N83_RS16960	COG0745	RESPONSE REGULATOR receiver
E3N83_RS16965	COG5002	protein histidine kinase activity
E3N83_RS16975	COG0588	phosphoglycerate mutase activity
E3N83_RS16990	COG1329	Transcriptional regulator
E3N83_RS17005	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E3N83_RS17020	COG3732	PTS system glucitol sorbitol-specific
E3N83_RS17045	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS17050	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3N83_RS17050	COG0022	dehydrogenase e1 component
E3N83_RS17055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3N83_RS17060	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E3N83_RS17080	COG0215	cysteine-tRNA ligase activity
E3N83_RS17090	COG1960	acyl-CoA dehydrogenase activity
E3N83_RS17105	COG3959	Transketolase, thiamine diphosphate binding domain
E3N83_RS17110	COG3958	Transketolase
E3N83_RS17125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E3N83_RS17135	COG0667	Aldo Keto reductase
E3N83_RS17150	COG1872	DUF167
E3N83_RS17160	COG0659	secondary active sulfate transmembrane transporter activity
E3N83_RS17165	COG3384	dioxygenase
E3N83_RS17170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E3N83_RS17190	COG3795	YCII-related domain
E3N83_RS17235	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3N83_RS17260	COG1132	(ABC) transporter
E3N83_RS17265	COG1132	(ABC) transporter
E3N83_RS17285	COG4941	Belongs to the sigma-70 factor family
E3N83_RS17295	COG3795	YCII-related domain
E3N83_RS17305	COG0156	8-amino-7-oxononanoate synthase activity
E3N83_RS17315	COG0459	protein refolding
E3N83_RS17350	COG0542	response to heat
E3N83_RS17425	COG4591	ABC-type transport system involved in lipoprotein release permease component
E3N83_RS17425	COG1136	(ABC) transporter
E3N83_RS17430	COG0577	efflux transmembrane transporter activity
E3N83_RS17480	COG1061	Type III restriction enzyme res subunit
E3N83_RS17485	COG3265	gluconokinase activity
E3N83_RS17495	COG1819	glycosyl
E3N83_RS17505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E3N83_RS17535	COG0318	PFAM AMP-dependent synthetase and ligase
E3N83_RS17550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3N83_RS17570	COG1278	Cold shock
E3N83_RS17575	COG2814	Major facilitator Superfamily
E3N83_RS17590	COG2252	PERMEase
E3N83_RS17595	COG1846	Transcriptional regulator
E3N83_RS17600	COG2814	Major facilitator Superfamily
E3N83_RS17605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E3N83_RS17610	COG0049	tRNA binding
E3N83_RS17615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E3N83_RS17620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E3N83_RS17655	COG0745	RESPONSE REGULATOR receiver
E3N83_RS17660	COG2205	protein histidine kinase activity
E3N83_RS17675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E3N83_RS17705	COG0051	transcription antitermination factor activity, RNA binding
E3N83_RS17710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E3N83_RS17715	COG0088	Forms part of the polypeptide exit tunnel
E3N83_RS17720	COG0089	rRNA binding
E3N83_RS17725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E3N83_RS17730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3N83_RS17735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3N83_RS17740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E3N83_RS17745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3N83_RS17750	COG0255	Belongs to the universal ribosomal protein uL29 family
E3N83_RS17755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E3N83_RS17760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E3N83_RS17765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E3N83_RS17770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E3N83_RS17775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E3N83_RS17780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E3N83_RS17785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E3N83_RS17790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E3N83_RS17795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E3N83_RS17800	COG1841	ribosomal large subunit assembly
E3N83_RS17805	COG0200	Binds to the 23S rRNA
E3N83_RS17815	COG0563	adenylate kinase activity
E3N83_RS17840	COG0714	Associated with various cellular activities
E3N83_RS17870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3N83_RS17875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E3N83_RS17880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E3N83_RS17885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E3N83_RS17890	COG0202	RNA polymerase activity
E3N83_RS17895	COG0203	ribosomal protein L17
E3N83_RS17910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3N83_RS17920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E3N83_RS17955	COG2226	methyltransferase
E3N83_RS17995	COG1136	(ABC) transporter
E3N83_RS18050	COG1615	UPF0182 protein
E3N83_RS18060	COG0101	tRNA pseudouridine synthase activity
E3N83_RS18115	COG3064	Membrane
E3N83_RS18115	COG4991	sh3 domain protein
E3N83_RS18115	COG0515	serine threonine protein kinase
E3N83_RS18120	COG0210	DNA helicase
E3N83_RS18125	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E3N83_RS18130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3N83_RS18140	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E3N83_RS18145	COG0193	aminoacyl-tRNA hydrolase activity
E3N83_RS18155	COG1218	3'(2'),5'-bisphosphate nucleotidase
E3N83_RS18170	COG3629	intracellular signal transduction
E3N83_RS18180	COG2205	protein histidine kinase activity
E3N83_RS18205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3N83_RS18210	COG0573	inorganic phosphate transmembrane transporter activity
E3N83_RS18245	COG0148	phosphopyruvate hydratase activity
E3N83_RS18280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3N83_RS18295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E3N83_RS18335	COG1271	oxidase subunit
E3N83_RS18340	COG1294	oxidase, subunit
E3N83_RS18345	COG4988	ABC transporter
E3N83_RS18365	COG0517	IMP dehydrogenase activity
E3N83_RS18365	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3N83_RS18365	COG0617	tRNA 3'-terminal CCA addition
E3N83_RS18385	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E3N83_RS18430	COG0745	RESPONSE REGULATOR receiver
E3N83_RS18435	COG2205	protein histidine kinase activity
E3N83_RS18445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3N83_RS18460	COG2318	DinB family
E3N83_RS18475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E3N83_RS18490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E3N83_RS18510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3N83_RS18515	COG2197	response regulator
E3N83_RS18520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E3N83_RS18530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS18565	COG2068	MobA-Related Protein
E3N83_RS18570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3N83_RS18580	COG2755	lipolytic protein G-D-S-L family
E3N83_RS18580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3N83_RS18615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3N83_RS18630	COG1331	Highly conserved protein containing a thioredoxin domain
E3N83_RS18650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3N83_RS18655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E3N83_RS18675	COG0114	fumarate hydratase activity
E3N83_RS18700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E3N83_RS18700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E3N83_RS18730	COG3842	ATPase activity
E3N83_RS18810	COG1722	exodeoxyribonuclease VII activity
E3N83_RS18815	COG1570	exodeoxyribonuclease VII activity
E3N83_RS18820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E3N83_RS18830	COG0009	L-threonylcarbamoyladenylate synthase
E3N83_RS18840	COG1322	Protein conserved in bacteria
E3N83_RS18880	COG0012	GTP binding
E3N83_RS18900	COG1316	TRANSCRIPTIONal
E3N83_RS18920	COG2149	membrane
E3N83_RS18935	COG0494	nUDIX hydrolase
E3N83_RS18940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3N83_RS18955	COG0017	Asparaginyl-tRNA synthetase
E3N83_RS19025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3N83_RS19045	COG2171	N-acyltransferase activity
E3N83_RS19050	COG2318	DinB family
E3N83_RS19060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3N83_RS19070	COG1611	Belongs to the LOG family
E3N83_RS19090	COG1024	Enoyl-CoA hydratase
E3N83_RS19105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E3N83_RS19120	COG1595	DNA-templated transcription, initiation
E3N83_RS19130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3N83_RS19155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E3N83_RS19180	COG1012	belongs to the aldehyde dehydrogenase family
E3N83_RS19195	COG2902	Dehydrogenase
E3N83_RS19205	COG2205	protein histidine kinase activity
E3N83_RS19210	COG0745	RESPONSE REGULATOR receiver
E3N83_RS19215	COG1132	(ABC) transporter
E3N83_RS19220	COG1132	(ABC) transporter
E3N83_RS19255	COG0438	transferase activity, transferring glycosyl groups
E3N83_RS19275	COG4941	Belongs to the sigma-70 factor family
E3N83_RS19280	COG1131	(ABC) transporter
E3N83_RS19325	COG1442	glycosyl transferase family 8
E3N83_RS19325	COG1216	Glycosyl transferase, family 2
E3N83_RS19335	COG0438	transferase activity, transferring glycosyl groups
E3N83_RS19395	COG2213	PTS system mannitol-specific