locus-tag	class	description
E2C04_RS00010	COG0592	DNA-directed DNA polymerase activity
E2C04_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
E2C04_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E2C04_RS00030	COG0187	DNA topoisomerase II activity
E2C04_RS00110	COG0515	serine threonine protein kinase
E2C04_RS00115	COG0515	serine threonine protein kinase
E2C04_RS00150	COG0582	viral genome integration into host DNA
E2C04_RS00260	COG0785	Cytochrome C biogenesis protein
E2C04_RS00285	COG3336	cytochrome c oxidase
E2C04_RS00425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2C04_RS00610	COG2124	cytochrome p450
E2C04_RS00620	COG2409	Drug exporters of the RND superfamily
E2C04_RS00625	COG2409	Drug exporters of the RND superfamily
E2C04_RS00645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2C04_RS00655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2C04_RS00655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2C04_RS00665	COG0785	Cytochrome C biogenesis protein
E2C04_RS00690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2C04_RS00695	COG3336	cytochrome c oxidase
E2C04_RS00760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2C04_RS00820	COG0488	(ABC) transporter
E2C04_RS00835	COG0386	Belongs to the glutathione peroxidase family
E2C04_RS00865	COG0733	neurotransmitter:sodium symporter activity
E2C04_RS00885	COG2211	Major facilitator Superfamily
E2C04_RS00890	COG0300	oxidoreductase activity
E2C04_RS00895	COG0492	ferredoxin-NADP+ reductase activity
E2C04_RS00910	COG3590	peptidase
E2C04_RS00920	COG0514	ATP-dependent DNA helicase (RecQ)
E2C04_RS00935	COG0477	Major facilitator Superfamily
E2C04_RS00940	COG0386	Belongs to the glutathione peroxidase family
E2C04_RS00965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2C04_RS01000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2C04_RS01030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2C04_RS01035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2C04_RS01170	COG4585	Histidine kinase
E2C04_RS01175	COG2197	response regulator
E2C04_RS01180	COG1136	(ABC) transporter
E2C04_RS01180	COG0577	efflux transmembrane transporter activity
E2C04_RS01185	COG2814	Major facilitator Superfamily
E2C04_RS01215	COG1741	Belongs to the pirin family
E2C04_RS01245	COG1902	pentaerythritol trinitrate reductase activity
E2C04_RS01245	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2C04_RS01255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2C04_RS01265	COG0513	Belongs to the DEAD box helicase family
E2C04_RS01280	COG0702	epimerase
E2C04_RS01290	COG1695	Transcriptional regulator
E2C04_RS01295	COG0577	efflux transmembrane transporter activity
E2C04_RS01295	COG1136	(ABC) transporter
E2C04_RS01310	COG0183	Belongs to the thiolase family
E2C04_RS01335	COG1129	ABC transporter
E2C04_RS01335	COG0842	Transport permease protein
E2C04_RS01355	COG0765	amino acid transport
E2C04_RS01440	COG1595	DNA-templated transcription, initiation
E2C04_RS01445	COG0488	(ABC) transporter
E2C04_RS01455	COG1595	DNA-templated transcription, initiation
E2C04_RS01510	COG1595	DNA-templated transcription, initiation
E2C04_RS01525	COG3119	arylsulfatase activity
E2C04_RS01540	COG2205	protein histidine kinase activity
E2C04_RS01555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2C04_RS01560	COG1950	PFAM Membrane protein of
E2C04_RS01580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2C04_RS01585	COG0435	Glutathione S-transferase
E2C04_RS01595	COG0477	Major facilitator Superfamily
E2C04_RS01610	COG0022	dehydrogenase e1 component
E2C04_RS01645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2C04_RS01650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS01770	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS01775	COG0730	response to heat
E2C04_RS01810	COG0717	Belongs to the dCTP deaminase family
E2C04_RS01835	COG0247	lactate metabolic process
E2C04_RS01835	COG2181	nitrate reductase activity
E2C04_RS01850	COG2986	histidine ammonia-lyase
E2C04_RS01885	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2C04_RS01895	COG2301	Belongs to the HpcH HpaI aldolase family
E2C04_RS01915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2C04_RS01920	COG2111	Na H antiporter
E2C04_RS01920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2C04_RS01925	COG1006	Multisubunit Na H antiporter MnhC subunit
E2C04_RS01945	COG1320	monovalent cation:proton antiporter activity
E2C04_RS01950	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
E2C04_RS01950	COG0778	Nitroreductase
E2C04_RS01965	COG1228	amidohydrolase
E2C04_RS01985	COG2197	response regulator
E2C04_RS02010	COG0443	Heat shock 70 kDa protein
E2C04_RS02015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2C04_RS02020	COG0484	heat shock protein binding
E2C04_RS02025	COG0789	Transcriptional regulator
E2C04_RS02030	COG1357	PFAM Pentapeptide repeats (8 copies)
E2C04_RS02035	COG2201	protein-glutamate methylesterase activity
E2C04_RS02055	COG0542	response to heat
E2C04_RS02075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2C04_RS02080	COG0586	Pfam SNARE associated Golgi protein
E2C04_RS02110	COG0191	fructose-bisphosphate aldolase activity
E2C04_RS02140	COG2197	response regulator
E2C04_RS02145	COG1597	lipid kinase activity
E2C04_RS02150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2C04_RS02155	COG4221	oxidoreductase activity
E2C04_RS02220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2C04_RS02315	COG5002	protein histidine kinase activity
E2C04_RS02325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2C04_RS02340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2C04_RS02380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2C04_RS02425	COG1252	NADH dehydrogenase
E2C04_RS02455	COG3123	guanosine phosphorylase activity
E2C04_RS02515	COG1278	Cold shock
E2C04_RS02520	COG1937	Protein conserved in bacteria
E2C04_RS02525	COG2608	mercury ion transmembrane transporter activity
E2C04_RS02545	COG3559	Exporter of polyketide antibiotics
E2C04_RS02570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2C04_RS02580	COG0306	phosphate transporter
E2C04_RS02595	COG1490	D-aminoacyl-tRNA deacylase activity
E2C04_RS02600	COG3246	L-lysine catabolic process to acetate
E2C04_RS02615	COG4044	May play a role in the intracellular transport of hydrophobic ligands
E2C04_RS02620	COG0735	belongs to the Fur family
E2C04_RS02625	COG0354	folic acid binding
E2C04_RS02630	COG0454	-acetyltransferase
E2C04_RS02630	COG0456	acetyltransferase
E2C04_RS02635	COG0745	RESPONSE REGULATOR receiver
E2C04_RS02700	COG0584	glycerophosphoryl diester phosphodiesterase
E2C04_RS02725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E2C04_RS02730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2C04_RS02735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2C04_RS02740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E2C04_RS02750	COG1086	Polysaccharide biosynthesis protein
E2C04_RS02760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2C04_RS02805	COG0529	Catalyzes the synthesis of activated sulfate
E2C04_RS02825	COG1086	Polysaccharide biosynthesis protein
E2C04_RS02830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E2C04_RS02830	COG0662	Cupin 2, conserved barrel domain protein
E2C04_RS02840	COG1088	dTDP-glucose 4,6-dehydratase activity
E2C04_RS02850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E2C04_RS02870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2C04_RS02920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2C04_RS02925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2C04_RS02945	COG2409	Drug exporters of the RND superfamily
E2C04_RS02970	COG1013	pyruvate-flavodoxin oxidoreductase activity
E2C04_RS02980	COG1012	belongs to the aldehyde dehydrogenase family
E2C04_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
E2C04_RS02990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS03010	COG2030	dehydratase
E2C04_RS03060	COG1053	succinate dehydrogenase
E2C04_RS03095	COG1053	succinate dehydrogenase
E2C04_RS03095	COG3976	FMN-binding domain protein
E2C04_RS03110	COG1079	Belongs to the binding-protein-dependent transport system permease family
E2C04_RS03115	COG1126	abc transporter atp-binding protein
E2C04_RS03130	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS03135	COG1024	Enoyl-CoA hydratase
E2C04_RS03140	COG1024	Enoyl-CoA hydratase
E2C04_RS03145	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS03195	COG0535	radical SAM domain protein
E2C04_RS03225	COG0657	acetylesterase activity
E2C04_RS03240	COG1024	Enoyl-CoA hydratase
E2C04_RS03250	COG0183	Belongs to the thiolase family
E2C04_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
E2C04_RS03275	COG2186	Transcriptional regulator
E2C04_RS03280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2C04_RS03315	COG0183	Belongs to the thiolase family
E2C04_RS03320	COG1024	Enoyl-CoA hydratase
E2C04_RS03345	COG0601	transmembrane transport
E2C04_RS03350	COG0789	Transcriptional regulator
E2C04_RS03360	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS03380	COG0300	oxidoreductase activity
E2C04_RS03400	COG1966	Carbon starvation protein
E2C04_RS03485	COG1794	racemase activity, acting on amino acids and derivatives
E2C04_RS03495	COG0328	RNA-DNA hybrid ribonuclease activity
E2C04_RS03515	COG0697	spore germination
E2C04_RS03525	COG5002	protein histidine kinase activity
E2C04_RS03530	COG0704	Plays a role in the regulation of phosphate uptake
E2C04_RS03555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2C04_RS03555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2C04_RS03565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2C04_RS03580	COG0215	cysteine-tRNA ligase activity
E2C04_RS03595	COG3663	DNA glycosylase
E2C04_RS03670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2C04_RS03690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS03695	COG0431	NADPH-dependent FMN reductase
E2C04_RS03700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2C04_RS03710	COG3253	May function as heme-dependent peroxidase
E2C04_RS03720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2C04_RS03755	COG0438	transferase activity, transferring glycosyl groups
E2C04_RS03765	COG1793	dna ligase
E2C04_RS03780	COG3842	ATPase activity
E2C04_RS03795	COG0395	ABC-type sugar transport system, permease component
E2C04_RS03800	COG2723	6-phospho-beta-galactosidase activity
E2C04_RS03820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2C04_RS03840	COG0193	aminoacyl-tRNA hydrolase activity
E2C04_RS03845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2C04_RS03850	COG1215	transferase activity, transferring glycosyl groups
E2C04_RS03935	COG3956	TIGRFAM MazG family protein
E2C04_RS03940	COG0148	phosphopyruvate hydratase activity
E2C04_RS04020	COG1739	Uncharacterized protein family UPF0029
E2C04_RS04035	COG3012	SEC-C Motif Domain Protein
E2C04_RS04075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2C04_RS04090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2C04_RS04095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2C04_RS04105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E2C04_RS04125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2C04_RS04130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2C04_RS04170	COG2409	Drug exporters of the RND superfamily
E2C04_RS04180	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS04190	COG0431	NADPH-dependent FMN reductase
E2C04_RS04195	COG0693	protein deglycase activity
E2C04_RS04200	COG2267	carboxylic ester hydrolase activity
E2C04_RS04235	COG0352	thiamine-phosphate diphosphorylase activity
E2C04_RS04235	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E2C04_RS04240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2C04_RS04240	COG2022	thiamine diphosphate biosynthetic process
E2C04_RS04250	COG2022	thiamine diphosphate biosynthetic process
E2C04_RS04255	COG0351	phosphomethylpyrimidine kinase
E2C04_RS04310	COG1722	exodeoxyribonuclease VII activity
E2C04_RS04320	COG2890	protein-(glutamine-N5) methyltransferase activity
E2C04_RS04325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2C04_RS04375	COG0012	GTP binding
E2C04_RS04380	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
E2C04_RS04410	COG2226	methyltransferase
E2C04_RS04415	COG0640	Transcriptional regulator
E2C04_RS04465	COG1289	transmembrane transporter activity
E2C04_RS04475	COG2235	arginine
E2C04_RS04480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E2C04_RS04495	COG0489	protein tyrosine kinase activity
E2C04_RS04495	COG3206	protein involved in exopolysaccharide biosynthesis
E2C04_RS04515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E2C04_RS04545	COG4604	ABC transporter, ATP-binding protein
E2C04_RS04555	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2C04_RS04560	COG4607	ABC-type enterochelin transport system periplasmic component
E2C04_RS04570	COG2171	N-acyltransferase activity
E2C04_RS04590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2C04_RS04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2C04_RS04620	COG1611	Belongs to the LOG family
E2C04_RS04670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2C04_RS04715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E2C04_RS04720	COG3285	dna ligase
E2C04_RS04720	COG1793	dna ligase
E2C04_RS04735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2C04_RS04850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E2C04_RS04900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2C04_RS04910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E2C04_RS04915	COG2884	Cell division ATP-binding protein ftsE
E2C04_RS04925	COG0741	lytic transglycosylase activity
E2C04_RS04925	COG0739	heme binding
E2C04_RS04925	COG1196	nuclear chromosome segregation
E2C04_RS04930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2C04_RS04960	COG0668	transmembrane transport
E2C04_RS04965	COG1764	response to oxidative stress
E2C04_RS05010	COG1678	Uncharacterized ACR, COG1678
E2C04_RS05030	COG1414	Transcriptional regulator
E2C04_RS05060	COG1126	abc transporter atp-binding protein
E2C04_RS05065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2C04_RS05070	COG1024	Enoyl-CoA hydratase
E2C04_RS05075	COG1335	isochorismatase
E2C04_RS05090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2C04_RS05125	COG1234	tRNA 3'-trailer cleavage
E2C04_RS05130	COG1131	(ABC) transporter
E2C04_RS05140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2C04_RS05145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2C04_RS05160	COG1131	(ABC) transporter
E2C04_RS05180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2C04_RS05185	COG2205	protein histidine kinase activity
E2C04_RS05225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2C04_RS05245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2C04_RS05250	COG0110	maltose O-acetyltransferase activity
E2C04_RS05260	COG1742	UPF0060 membrane protein
E2C04_RS05285	COG0589	response to stress
E2C04_RS05315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2C04_RS05325	COG0006	proline dipeptidase activity
E2C04_RS05330	COG2339	peptidase activity
E2C04_RS05360	COG0824	Thioesterase
E2C04_RS05370	COG0668	transmembrane transport
E2C04_RS05395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E2C04_RS05415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2C04_RS05430	COG0698	ribose 5-phosphate isomerase
E2C04_RS05455	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2C04_RS05460	COG0740	serine-type endopeptidase activity
E2C04_RS05465	COG0740	serine-type endopeptidase activity
E2C04_RS05470	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2C04_RS05520	COG0105	UTP biosynthetic process
E2C04_RS05540	COG0768	penicillin binding
E2C04_RS05545	COG0772	Belongs to the SEDS family
E2C04_RS05550	COG0387	Pfam Sodium calcium exchanger
E2C04_RS05585	COG1530	ribonuclease E activity
E2C04_RS05590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2C04_RS05595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2C04_RS05600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2C04_RS05665	COG2226	methyltransferase
E2C04_RS05705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2C04_RS05715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2C04_RS05720	COG0154	amidase activity
E2C04_RS05725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2C04_RS05745	COG3845	ABC transporter
E2C04_RS05750	COG3845	ABC transporter
E2C04_RS05780	COG0129	dihydroxy-acid dehydratase activity
E2C04_RS05840	COG0440	acetolactate synthase activity
E2C04_RS05865	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E2C04_RS05895	COG0473	3-isopropylmalate dehydrogenase activity
E2C04_RS05900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2C04_RS05915	COG0154	amidase activity
E2C04_RS05925	COG1122	ATPase activity
E2C04_RS05930	COG1268	BioY protein
E2C04_RS05950	COG2340	Cysteine-rich secretory protein family
E2C04_RS05965	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2C04_RS05970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2C04_RS05970	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E2C04_RS06000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2C04_RS06010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2C04_RS06015	COG0066	3-isopropylmalate dehydratase activity
E2C04_RS06020	COG1920	GTP binding
E2C04_RS06060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2C04_RS06065	COG1461	Dihydroxyacetone kinase
E2C04_RS06075	COG0742	ribosomal rna small subunit methyltransferase
E2C04_RS06080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2C04_RS06090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2C04_RS06095	COG0571	ribonuclease III activity
E2C04_RS06100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2C04_RS06155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2C04_RS06190	COG0228	four-way junction DNA binding
E2C04_RS06195	COG1837	Belongs to the UPF0109 family
E2C04_RS06210	COG0336	Belongs to the RNA methyltransferase TrmD family
E2C04_RS06215	COG0335	large ribosomal subunit rRNA binding
E2C04_RS06220	COG0681	Belongs to the peptidase S26 family
E2C04_RS06225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E2C04_RS06250	COG4974	Belongs to the 'phage' integrase family
E2C04_RS06260	COG0052	Belongs to the universal ribosomal protein uS2 family
E2C04_RS06265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2C04_RS06270	COG0528	UMP kinase activity
E2C04_RS06290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2C04_RS06335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E2C04_RS06355	COG0779	Required for maturation of 30S ribosomal subunits
E2C04_RS06380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2C04_RS06385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2C04_RS06410	COG1349	DNA-binding transcription factor activity
E2C04_RS06415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2C04_RS06420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E2C04_RS06425	COG1185	polyribonucleotide nucleotidyltransferase activity
E2C04_RS06430	COG0612	Peptidase, M16
E2C04_RS06530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2C04_RS06565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2C04_RS06570	COG0723	plastoquinol--plastocyanin reductase activity
E2C04_RS06575	COG2010	Cytochrome c
E2C04_RS06580	COG1845	cytochrome c oxidase, subunit III
E2C04_RS06590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2C04_RS06605	COG1368	sulfuric ester hydrolase activity
E2C04_RS06650	COG0463	Glycosyl transferase, family 2
E2C04_RS06680	COG0501	Belongs to the peptidase M48B family
E2C04_RS06725	COG2894	cell division
E2C04_RS06745	COG0003	Pfam Anion-transporting ATPase
E2C04_RS06755	COG1940	carbohydrate kinase activity
E2C04_RS06805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E2C04_RS06855	COG0142	geranyltranstransferase activity
E2C04_RS06930	COG0714	Associated with various cellular activities
E2C04_RS06935	COG2001	Belongs to the MraZ family
E2C04_RS06950	COG0768	penicillin binding
E2C04_RS06955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2C04_RS06960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2C04_RS06965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2C04_RS06970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2C04_RS06980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2C04_RS06990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2C04_RS07005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E2C04_RS07010	COG1799	cell septum assembly
E2C04_RS07025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E2C04_RS07030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2C04_RS07055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2C04_RS07060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2C04_RS07065	COG0131	Imidazoleglycerol-phosphate dehydratase
E2C04_RS07070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2C04_RS07075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2C04_RS07080	COG0107	imidazoleglycerol-phosphate synthase activity
E2C04_RS07085	COG1132	(ABC) transporter
E2C04_RS07090	COG1132	(ABC) transporter
E2C04_RS07095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E2C04_RS07120	COG0133	tryptophan synthase activity
E2C04_RS07125	COG0159	tryptophan synthase activity
E2C04_RS07130	COG1999	signal sequence binding
E2C04_RS07135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E2C04_RS07140	COG0069	glutamate synthase activity
E2C04_RS07140	COG0067	glutamate synthase
E2C04_RS07140	COG0070	glutamate synthase
E2C04_RS07150	COG0469	pyruvate kinase activity
E2C04_RS07165	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2C04_RS07210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2C04_RS07210	COG2755	lipolytic protein G-D-S-L family
E2C04_RS07225	COG4981	capsule polysaccharide biosynthetic process
E2C04_RS07230	COG4981	capsule polysaccharide biosynthetic process
E2C04_RS07245	COG0438	transferase activity, transferring glycosyl groups
E2C04_RS07260	COG2226	methyltransferase
E2C04_RS07270	COG0539	negative regulation of cytoplasmic translation
E2C04_RS07275	COG0237	dephospho-CoA kinase activity
E2C04_RS07305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2C04_RS07325	COG0589	response to stress
E2C04_RS07365	COG0187	DNA topoisomerase II activity
E2C04_RS07380	COG0477	Major facilitator Superfamily
E2C04_RS07490	COG0756	dUTP diphosphatase activity
E2C04_RS07515	COG0569	domain protein
E2C04_RS07525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2C04_RS07540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2C04_RS07590	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2C04_RS07600	COG0531	amino acid
E2C04_RS07615	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2C04_RS07615	COG1024	Enoyl-CoA hydratase
E2C04_RS07630	COG1946	Acyl-CoA thioesterase
E2C04_RS07635	COG1196	nuclear chromosome segregation
E2C04_RS07635	COG0741	lytic transglycosylase activity
E2C04_RS07635	COG0739	heme binding
E2C04_RS07660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E2C04_RS07665	COG0540	Belongs to the ATCase OTCase family
E2C04_RS07670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2C04_RS07695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2C04_RS07700	COG0167	dihydroorotate dehydrogenase activity
E2C04_RS07710	COG0543	2 iron, 2 sulfur cluster binding
E2C04_RS07715	COG0167	dihydroorotate dehydrogenase activity
E2C04_RS07720	COG0284	orotidine-5'-phosphate decarboxylase activity
E2C04_RS07725	COG0194	GDP metabolic process
E2C04_RS07730	COG1758	RNA polymerase activity
E2C04_RS07740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2C04_RS07745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2C04_RS07750	COG0242	peptide deformylase activity
E2C04_RS07755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2C04_RS07795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2C04_RS07795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2C04_RS07800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2C04_RS07805	COG0140	phosphoribosyl-ATP diphosphatase activity
E2C04_RS07810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E2C04_RS07850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2C04_RS07855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2C04_RS07860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2C04_RS07880	COG5002	protein histidine kinase activity
E2C04_RS07885	COG0745	RESPONSE REGULATOR receiver
E2C04_RS07895	COG5002	protein histidine kinase activity
E2C04_RS07905	COG0072	phenylalanine-tRNA ligase activity
E2C04_RS07905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2C04_RS07915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2C04_RS07930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E2C04_RS07935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2C04_RS07940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2C04_RS07945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2C04_RS07950	COG1438	arginine binding
E2C04_RS07990	COG0647	UMP catabolic process
E2C04_RS08010	COG0497	DNA recombination
E2C04_RS08030	COG0504	CTP synthase activity
E2C04_RS08065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2C04_RS08080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2C04_RS08085	COG0204	Acyl-transferase
E2C04_RS08090	COG1160	GTP binding
E2C04_RS08175	COG1414	Transcriptional regulator
E2C04_RS08190	COG0783	Belongs to the Dps family
E2C04_RS08265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS08275	COG2860	membrane
E2C04_RS08280	COG0420	3'-5' exonuclease activity
E2C04_RS08285	COG0419	ATPase involved in DNA repair
E2C04_RS08290	COG0419	ATPase involved in DNA repair
E2C04_RS08325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2C04_RS08335	COG0483	inositol monophosphate 1-phosphatase activity
E2C04_RS08340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2C04_RS08350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
E2C04_RS08365	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E2C04_RS08370	COG0217	transcriptional regulatory protein
E2C04_RS08385	COG0632	four-way junction helicase activity
E2C04_RS08390	COG2255	four-way junction helicase activity
E2C04_RS08410	COG1196	nuclear chromosome segregation
E2C04_RS08420	COG0124	histidyl-tRNA synthetase
E2C04_RS08430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2C04_RS08445	COG0444	Belongs to the ABC transporter superfamily
E2C04_RS08470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2C04_RS08475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2C04_RS08480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2C04_RS08485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2C04_RS08495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2C04_RS08500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2C04_RS08505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2C04_RS08510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2C04_RS08515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2C04_RS08520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2C04_RS08555	COG2018	Roadblock/LC7 domain
E2C04_RS08575	COG0492	ferredoxin-NADP+ reductase activity
E2C04_RS08600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2C04_RS08620	COG0723	plastoquinol--plastocyanin reductase activity
E2C04_RS08630	COG0322	excinuclease ABC activity
E2C04_RS08645	COG1481	regulation of sporulation
E2C04_RS08650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2C04_RS08655	COG0126	phosphoglycerate kinase activity
E2C04_RS08660	COG0149	triose-phosphate isomerase activity
E2C04_RS08665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2C04_RS08675	COG0363	glucosamine-6-phosphate deaminase activity
E2C04_RS08690	COG0166	Belongs to the GPI family
E2C04_RS08695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2C04_RS08705	COG0109	protoheme IX farnesyltransferase activity
E2C04_RS08715	COG1612	heme a metabolic process
E2C04_RS08740	COG0719	Fe-S assembly protein
E2C04_RS08750	COG0396	ATPase activity
E2C04_RS08765	COG2151	metal-sulfur cluster biosynthetic enzyme
E2C04_RS08800	COG1024	Enoyl-CoA hydratase
E2C04_RS08805	COG1132	(ABC) transporter
E2C04_RS08820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2C04_RS08850	COG3830	Belongs to the UPF0237 family
E2C04_RS08850	COG0560	Phosphoserine phosphatase
E2C04_RS08855	COG1119	ATPase activity
E2C04_RS08870	COG0730	response to heat
E2C04_RS08885	COG0431	NADPH-dependent FMN reductase
E2C04_RS08915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E2C04_RS08950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2C04_RS08995	COG0215	cysteine-tRNA ligase activity
E2C04_RS09020	COG2323	membrane
E2C04_RS09040	COG1222	aaa ATPase
E2C04_RS09055	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E2C04_RS09060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E2C04_RS09065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
E2C04_RS09090	COG0805	protein transport
E2C04_RS09110	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E2C04_RS09125	COG0604	alcohol dehydrogenase
E2C04_RS09130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E2C04_RS09135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E2C04_RS09140	COG1607	acyl-coa hydrolase
E2C04_RS09150	COG1216	Glycosyl transferase, family 2
E2C04_RS09195	COG0667	Aldo Keto reductase
E2C04_RS09200	COG2234	aminopeptidase activity
E2C04_RS09275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E2C04_RS09290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2C04_RS09295	COG1765	OsmC-like protein
E2C04_RS09315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2C04_RS09340	COG1716	ATPase activity
E2C04_RS09345	COG0509	glycine decarboxylation via glycine cleavage system
E2C04_RS09370	COG1253	flavin adenine dinucleotide binding
E2C04_RS09380	COG0110	maltose O-acetyltransferase activity
E2C04_RS09400	COG2188	Transcriptional regulator
E2C04_RS09410	COG1802	Transcriptional regulator
E2C04_RS09440	COG1335	isochorismatase
E2C04_RS09470	COG2205	protein histidine kinase activity
E2C04_RS09540	COG0406	alpha-ribazole phosphatase activity
E2C04_RS09555	COG1492	cobalamin metabolic process
E2C04_RS09585	COG1120	ATPase activity
E2C04_RS09600	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E2C04_RS09615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2C04_RS09615	COG1648	precorrin-2 dehydrogenase activity
E2C04_RS09670	COG0577	efflux transmembrane transporter activity
E2C04_RS09675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2C04_RS09700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E2C04_RS09730	COG1185	polyribonucleotide nucleotidyltransferase activity
E2C04_RS09780	COG1201	RNA secondary structure unwinding
E2C04_RS09830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2C04_RS10170	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E2C04_RS10180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2C04_RS10190	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS10200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2C04_RS10210	COG0175	sulfate reduction
E2C04_RS10240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2C04_RS10245	COG0477	Major facilitator Superfamily
E2C04_RS10260	COG1201	RNA secondary structure unwinding
E2C04_RS10265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2C04_RS10270	COG1396	sequence-specific DNA binding
E2C04_RS10275	COG1058	Belongs to the CinA family
E2C04_RS10275	COG1546	Belongs to the CinA family
E2C04_RS10285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2C04_RS10295	COG1674	ftsk spoiiie
E2C04_RS10305	COG3227	Zinc metalloprotease (Elastase)
E2C04_RS10330	COG1294	oxidase, subunit
E2C04_RS10345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E2C04_RS10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2C04_RS10360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2C04_RS10370	COG2188	Transcriptional regulator
E2C04_RS10380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2C04_RS10385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2C04_RS10420	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2C04_RS10430	COG1090	epimerase
E2C04_RS10440	COG0321	lipoyl(octanoyl) transferase activity
E2C04_RS10465	COG0174	glutamine synthetase
E2C04_RS10495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E2C04_RS10525	COG0693	protein deglycase activity
E2C04_RS10580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2C04_RS10580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2C04_RS10590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2C04_RS10620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS10660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2C04_RS10675	COG1278	Cold shock
E2C04_RS10690	COG0723	plastoquinol--plastocyanin reductase activity
E2C04_RS10690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2C04_RS10740	COG0135	phosphoribosylanthranilate isomerase activity
E2C04_RS10770	COG1064	alcohol dehydrogenase
E2C04_RS10805	COG1216	Glycosyl transferase, family 2
E2C04_RS10830	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E2C04_RS10865	COG1160	GTP binding
E2C04_RS10875	COG2011	ABC-type metal ion transport system permease component
E2C04_RS10880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2C04_RS10885	COG1464	Belongs to the NlpA lipoprotein family
E2C04_RS10895	COG1054	Belongs to the UPF0176 family
E2C04_RS10910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2C04_RS10950	COG3135	benzoate transporter
E2C04_RS11030	COG0142	geranyltranstransferase activity
E2C04_RS11125	COG1643	Atp-dependent helicase
E2C04_RS11145	COG0121	glutamine amidotransferase
E2C04_RS11150	COG0579	oxidoreductase
E2C04_RS11195	COG1917	Cupin 2, conserved barrel domain protein
E2C04_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
E2C04_RS11205	COG0778	Nitroreductase
E2C04_RS11220	COG2409	Drug exporters of the RND superfamily
E2C04_RS11250	COG0557	exoribonuclease II activity
E2C04_RS11275	COG3022	response to hydroperoxide
E2C04_RS11300	COG5002	protein histidine kinase activity
E2C04_RS11305	COG0745	RESPONSE REGULATOR receiver
E2C04_RS11330	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS11340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2C04_RS11360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2C04_RS11365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2C04_RS11405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2C04_RS11410	COG2815	serine threonine protein kinase
E2C04_RS11410	COG0515	serine threonine protein kinase
E2C04_RS11415	COG0438	transferase activity, transferring glycosyl groups
E2C04_RS11450	COG0358	DNA primase activity
E2C04_RS11465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2C04_RS11470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2C04_RS11495	COG0423	glycine-tRNA ligase activity
E2C04_RS11525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2C04_RS11540	COG1381	Involved in DNA repair and RecF pathway recombination
E2C04_RS11555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2C04_RS11570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2C04_RS11590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E2C04_RS11600	COG0537	adenosine 5'-monophosphoramidase activity
E2C04_RS11620	COG1420	regulation of RNA biosynthetic process
E2C04_RS11645	COG1022	Amp-dependent synthetase and ligase
E2C04_RS11660	COG0268	Binds directly to 16S ribosomal RNA
E2C04_RS11670	COG0840	transmembrane signaling receptor activity
E2C04_RS11670	COG5278	phosphoserine phosphatase activity
E2C04_RS11690	COG1307	EDD domain protein, DegV family
E2C04_RS11695	COG0495	leucyl-tRNA aminoacylation
E2C04_RS11720	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2C04_RS11725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2C04_RS11730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E2C04_RS11770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2C04_RS11770	COG0574	Belongs to the PEP-utilizing enzyme family
E2C04_RS11790	COG2205	protein histidine kinase activity
E2C04_RS11810	COG0183	Belongs to the thiolase family
E2C04_RS11815	COG0346	lactoylglutathione lyase activity
E2C04_RS11830	COG0596	Alpha beta hydrolase
E2C04_RS11845	COG2197	response regulator
E2C04_RS11850	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2C04_RS11855	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
E2C04_RS11890	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2C04_RS11895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2C04_RS11900	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E2C04_RS11905	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2C04_RS11910	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2C04_RS11915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2C04_RS11920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2C04_RS11950	COG2890	protein-(glutamine-N5) methyltransferase activity
E2C04_RS11955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2C04_RS11960	COG0254	rRNA binding
E2C04_RS11975	COG0083	homoserine kinase activity
E2C04_RS11980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2C04_RS11985	COG0460	homoserine dehydrogenase
E2C04_RS11990	COG0019	diaminopimelate decarboxylase activity
E2C04_RS12030	COG3220	belongs to the UPF0276 family
E2C04_RS12035	COG2208	phosphoserine phosphatase activity
E2C04_RS12040	COG1215	transferase activity, transferring glycosyl groups
E2C04_RS12045	COG1366	Belongs to the anti-sigma-factor antagonist family
E2C04_RS12080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E2C04_RS12110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2C04_RS12120	COG0604	alcohol dehydrogenase
E2C04_RS12185	COG1595	DNA-templated transcription, initiation
E2C04_RS12195	COG2135	peptidase activity
E2C04_RS12220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2C04_RS12230	COG0483	inositol monophosphate 1-phosphatase activity
E2C04_RS12240	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E2C04_RS12250	COG2501	S4 domain
E2C04_RS12255	COG2733	membrane
E2C04_RS12260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2C04_RS12270	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS12290	COG0287	Prephenate dehydrogenase
E2C04_RS12290	COG1605	Chorismate mutase
E2C04_RS12315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2C04_RS12350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2C04_RS12370	COG2357	RelA SpoT domain protein
E2C04_RS12375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2C04_RS12395	COG2193	ferroxidase activity
E2C04_RS12420	COG2824	Alkylphosphonate utilization operon protein PhnA
E2C04_RS12445	COG1937	Protein conserved in bacteria
E2C04_RS12470	COG2072	flavoprotein involved in K transport
E2C04_RS12485	COG1615	UPF0182 protein
E2C04_RS12525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E2C04_RS12525	COG1796	DNA polymerase
E2C04_RS12575	COG2816	NAD+ diphosphatase activity
E2C04_RS12580	COG0813	purine-nucleoside phosphorylase activity
E2C04_RS12645	COG1192	Involved in chromosome partitioning
E2C04_RS12675	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS12715	COG2239	Acts as a magnesium transporter
E2C04_RS12730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2C04_RS12755	COG0653	protein targeting
E2C04_RS12760	COG3214	Protein conserved in bacteria
E2C04_RS12770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2C04_RS12780	COG5401	PFAM Sporulation and spore germination
E2C04_RS12795	COG5000	phosphorelay sensor kinase activity
E2C04_RS12795	COG5002	protein histidine kinase activity
E2C04_RS12800	COG0745	RESPONSE REGULATOR receiver
E2C04_RS12810	COG2354	Protein conserved in bacteria
E2C04_RS12820	COG2835	tetraacyldisaccharide 4'-kinase activity
E2C04_RS12875	COG0662	Cupin 2, conserved barrel domain protein
E2C04_RS12875	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E2C04_RS12930	COG1316	TRANSCRIPTIONal
E2C04_RS12970	COG1832	CoA-binding protein
E2C04_RS13000	COG0745	RESPONSE REGULATOR receiver
E2C04_RS13020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2C04_RS13035	COG0424	maF-like protein
E2C04_RS13045	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS13060	COG3842	ATPase activity
E2C04_RS13075	COG4770	biotin carboxylase activity
E2C04_RS13090	COG2385	sporulation resulting in formation of a cellular spore
E2C04_RS13115	COG4129	membrane
E2C04_RS13150	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2C04_RS13160	COG4558	Periplasmic binding protein
E2C04_RS13190	COG1012	belongs to the aldehyde dehydrogenase family
E2C04_RS13195	COG1012	belongs to the aldehyde dehydrogenase family
E2C04_RS13235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2C04_RS13255	COG1744	ABC transporter substrate-binding protein PnrA-like
E2C04_RS13265	COG4603	Belongs to the binding-protein-dependent transport system permease family
E2C04_RS13270	COG1079	Belongs to the binding-protein-dependent transport system permease family
E2C04_RS13275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E2C04_RS13275	COG1473	amidohydrolase
E2C04_RS13350	COG1674	ftsk spoiiie
E2C04_RS13405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2C04_RS13420	COG2814	Major facilitator Superfamily
E2C04_RS13445	COG0039	L-malate dehydrogenase activity
E2C04_RS13455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2C04_RS13460	COG0138	bifunctional purine biosynthesis protein purh
E2C04_RS13485	COG0045	succinate-CoA ligase (ADP-forming) activity
E2C04_RS13490	COG0739	heme binding
E2C04_RS13490	COG0741	lytic transglycosylase activity
E2C04_RS13490	COG1196	nuclear chromosome segregation
E2C04_RS13505	COG2207	Transcriptional regulator
E2C04_RS13560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS13575	COG4213	ABC transporter substrate-binding protein
E2C04_RS13585	COG0519	Catalyzes the synthesis of GMP from XMP
E2C04_RS13585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2C04_RS13620	COG0516	GMP reductase activity
E2C04_RS13640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2C04_RS13700	COG1214	PFAM Peptidase M22, glycoprotease
E2C04_RS13700	COG0456	acetyltransferase
E2C04_RS13705	COG0802	atpase or kinase
E2C04_RS13715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2C04_RS13730	COG0736	holo-[acyl-carrier-protein] synthase activity
E2C04_RS13735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2C04_RS13740	COG1072	(Pantothenic acid kinase))
E2C04_RS13745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2C04_RS13750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2C04_RS13770	COG1309	transcriptional regulator
E2C04_RS13805	COG2813	Specifically methylates the guanine in position
E2C04_RS13815	COG0640	Transcriptional regulator
E2C04_RS13835	COG0203	ribosomal protein L17
E2C04_RS13850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2C04_RS13855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2C04_RS13860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2C04_RS13865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2C04_RS13875	COG0563	adenylate kinase activity
E2C04_RS13885	COG0200	Binds to the 23S rRNA
E2C04_RS13890	COG1841	ribosomal large subunit assembly
E2C04_RS13895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2C04_RS13900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2C04_RS13905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2C04_RS13910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2C04_RS13915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2C04_RS13920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2C04_RS13930	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2C04_RS13935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2C04_RS13945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2C04_RS13950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2C04_RS13955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2C04_RS13960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2C04_RS13965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2C04_RS13970	COG0089	rRNA binding
E2C04_RS13975	COG0088	Forms part of the polypeptide exit tunnel
E2C04_RS13980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2C04_RS13985	COG0051	transcription antitermination factor activity, RNA binding
E2C04_RS14005	COG0714	Associated with various cellular activities
E2C04_RS14025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2C04_RS14035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2C04_RS14040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2C04_RS14045	COG0049	tRNA binding
E2C04_RS14050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2C04_RS14055	COG2814	Major facilitator Superfamily
E2C04_RS14105	COG1061	Type III restriction enzyme res subunit
E2C04_RS14110	COG2188	Transcriptional regulator
E2C04_RS14120	COG4591	ABC-type transport system involved in lipoprotein release permease component
E2C04_RS14120	COG1136	(ABC) transporter
E2C04_RS14145	COG1140	nitrate reductase beta subunit
E2C04_RS14165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2C04_RS14175	COG0459	protein refolding
E2C04_RS14235	COG0069	glutamate synthase activity
E2C04_RS14255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2C04_RS14285	COG3265	gluconokinase activity
E2C04_RS14290	COG2610	gluconate transmembrane transporter activity
E2C04_RS14295	COG2409	Drug exporters of the RND superfamily
E2C04_RS14305	COG0300	oxidoreductase activity
E2C04_RS14325	COG0842	Transport permease protein
E2C04_RS14335	COG1131	(ABC) transporter
E2C04_RS14340	COG2409	Drug exporters of the RND superfamily
E2C04_RS14375	COG1823	symporter activity
E2C04_RS14420	COG5002	protein histidine kinase activity
E2C04_RS14445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2C04_RS14465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2C04_RS14495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2C04_RS14530	COG1126	abc transporter atp-binding protein
E2C04_RS14535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2C04_RS14545	COG0765	amino acid transport
E2C04_RS14555	COG1846	Transcriptional regulator
E2C04_RS14565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2C04_RS14570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2C04_RS14575	COG3583	domain protein
E2C04_RS14580	COG0084	hydrolase, TatD family'
E2C04_RS14585	COG0596	Alpha beta hydrolase
E2C04_RS14615	COG0737	Belongs to the 5'-nucleotidase family
E2C04_RS14615	COG1525	nuclease
E2C04_RS14615	COG4085	toxin activity
E2C04_RS14620	COG1329	Transcriptional regulator
E2C04_RS14650	COG3842	ATPase activity
E2C04_RS14665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2C04_RS14670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E2C04_RS14675	COG1984	allophanate hydrolase subunit 2
E2C04_RS14700	COG0315	cyclic pyranopterin monophosphate synthase activity
E2C04_RS14700	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2C04_RS14705	COG0315	cyclic pyranopterin monophosphate synthase activity
E2C04_RS14720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2C04_RS14740	COG1970	mechanosensitive ion channel activity
E2C04_RS14755	COG3268	Saccharopine dehydrogenase
E2C04_RS14825	COG2201	protein-glutamate methylesterase activity
E2C04_RS14850	COG0643	Histidine kinase
E2C04_RS14850	COG2198	Histidine kinase
E2C04_RS14850	COG0784	Response regulator, receiver
E2C04_RS14855	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E2C04_RS14860	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E2C04_RS14865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2C04_RS14870	COG1256	bacterial-type flagellum assembly
E2C04_RS14870	COG4786	Flagellar basal body rod
E2C04_RS14880	COG1191	sigma factor activity
E2C04_RS14890	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E2C04_RS14905	COG0745	RESPONSE REGULATOR receiver
E2C04_RS14915	COG0745	RESPONSE REGULATOR receiver
E2C04_RS14925	COG1815	bacterial-type flagellum-dependent cell motility
E2C04_RS14935	COG1677	Flagellar hook-basal body complex protein FliE
E2C04_RS14950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2C04_RS14970	COG1196	nuclear chromosome segregation
E2C04_RS14970	COG0741	lytic transglycosylase activity
E2C04_RS14970	COG0739	heme binding
E2C04_RS14995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E2C04_RS15030	COG1987	bacterial-type flagellum assembly
E2C04_RS15070	COG0259	pyridoxamine-phosphate oxidase activity
E2C04_RS15095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2C04_RS15115	COG0247	lactate metabolic process
E2C04_RS15115	COG0277	FAD linked oxidase domain protein
E2C04_RS15125	COG0494	nUDIX hydrolase
E2C04_RS15130	COG3594	Acyltransferase
E2C04_RS15155	COG0085	RNA polymerase activity
E2C04_RS15160	COG0222	ribosome binding
E2C04_RS15165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2C04_RS15170	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E2C04_RS15175	COG0081	regulation of translation
E2C04_RS15180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2C04_RS15200	COG0436	Aminotransferase
E2C04_RS15205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2C04_RS15235	COG2030	dehydratase
E2C04_RS15240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2C04_RS15280	COG0519	Catalyzes the synthesis of GMP from XMP
E2C04_RS15295	COG2814	Major facilitator Superfamily
E2C04_RS15315	COG2197	response regulator
E2C04_RS15320	COG4585	Histidine kinase
E2C04_RS15340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2C04_RS15340	COG2755	lipolytic protein G-D-S-L family
E2C04_RS15345	COG0579	oxidoreductase
E2C04_RS15365	COG1666	GTP binding
E2C04_RS15380	COG4208	sulfate ABC transporter
E2C04_RS15390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E2C04_RS15400	COG1013	pyruvate-flavodoxin oxidoreductase activity
E2C04_RS15410	COG0142	geranyltranstransferase activity
E2C04_RS15415	COG1007	ATP synthesis coupled electron transport
E2C04_RS15430	COG0713	ATP synthesis coupled electron transport
E2C04_RS15435	COG0839	Belongs to the complex I subunit 6 family
E2C04_RS15440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2C04_RS15445	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2C04_RS15470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2C04_RS15475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2C04_RS15485	COG2226	methyltransferase
E2C04_RS15500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E2C04_RS15515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E2C04_RS15520	COG4948	Mandelate Racemase Muconate Lactonizing
E2C04_RS15570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2C04_RS15580	COG0785	Cytochrome C biogenesis protein
E2C04_RS15590	COG0406	alpha-ribazole phosphatase activity
E2C04_RS15600	COG0113	porphobilinogen synthase activity
E2C04_RS15610	COG0181	hydroxymethylbilane synthase activity
E2C04_RS15620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E2C04_RS15630	COG0318	PFAM AMP-dependent synthetase and ligase
E2C04_RS15665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E2C04_RS15700	COG0248	Ppx GppA phosphatase
E2C04_RS15720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E2C04_RS15725	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E2C04_RS15760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2C04_RS15770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2C04_RS15775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E2C04_RS15780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2C04_RS15785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2C04_RS15800	COG1216	Glycosyl transferase, family 2
E2C04_RS15820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E2C04_RS15825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2C04_RS15830	COG0302	gtp cyclohydrolase
E2C04_RS15845	COG0037	tRNA processing
E2C04_RS15855	COG2027	D-alanyl-D-alanine carboxypeptidase
E2C04_RS15860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2C04_RS15880	COG0569	domain protein
E2C04_RS15885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2C04_RS15900	COG3842	ATPase activity
E2C04_RS15905	COG4149	molybdate abc transporter
E2C04_RS15935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2C04_RS15945	COG1131	(ABC) transporter
E2C04_RS15975	COG2076	Multidrug Resistance protein
E2C04_RS15985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E2C04_RS16025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2C04_RS16045	COG1754	DNA topoisomerase type I activity
E2C04_RS16045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2C04_RS16085	COG0831	urea catabolic process
E2C04_RS16095	COG0804	urea catabolic process
E2C04_RS16105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E2C04_RS16110	COG0829	nickel cation binding
E2C04_RS16125	COG2890	protein-(glutamine-N5) methyltransferase activity
E2C04_RS16135	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E2C04_RS16140	COG1366	Belongs to the anti-sigma-factor antagonist family
E2C04_RS16145	COG1205	dead DEAH box helicase
E2C04_RS16145	COG1111	helicase
E2C04_RS16205	COG3275	phosphorelay sensor kinase activity
E2C04_RS16210	COG3279	Response regulator of the LytR AlgR family
E2C04_RS16255	COG2146	nitrite reductase [NAD(P)H] activity
E2C04_RS16255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2C04_RS16265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2C04_RS16265	COG2146	nitrite reductase [NAD(P)H] activity
E2C04_RS16280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2C04_RS16285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS16320	COG2770	Histidine kinase
E2C04_RS16320	COG2208	phosphoserine phosphatase activity
E2C04_RS16325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E2C04_RS16340	COG0494	nUDIX hydrolase
E2C04_RS16345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2C04_RS16390	COG0251	oxidation-reduction process
E2C04_RS16405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2C04_RS16435	COG1414	Transcriptional regulator
E2C04_RS16455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2C04_RS16495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E2C04_RS16500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E2C04_RS16540	COG1674	ftsk spoiiie
E2C04_RS16545	COG0433	COG0433 Predicted ATPase
E2C04_RS16570	COG0542	response to heat
E2C04_RS16760	COG3321	synthase
E2C04_RS16760	COG0604	alcohol dehydrogenase
E2C04_RS16790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2C04_RS16795	COG0686	Belongs to the AlaDH PNT family
E2C04_RS16810	COG3483	tryptophan 2,3-dioxygenase activity
E2C04_RS16820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2C04_RS16840	COG0189	ligase activity
E2C04_RS16860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E2C04_RS16870	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E2C04_RS16875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E2C04_RS16880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2C04_RS16890	COG0590	tRNA wobble adenosine to inosine editing
E2C04_RS16920	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2C04_RS16925	COG3119	arylsulfatase activity
E2C04_RS16935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2C04_RS16935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2C04_RS16940	COG0730	response to heat
E2C04_RS16950	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E2C04_RS16960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2C04_RS16965	COG0746	molybdenum cofactor guanylyltransferase activity
E2C04_RS16970	COG1063	alcohol dehydrogenase
E2C04_RS16985	COG0561	phosphatase activity
E2C04_RS16990	COG0561	phosphatase activity
E2C04_RS16995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2C04_RS17010	COG0077	Prephenate dehydratase
E2C04_RS17010	COG1605	Chorismate mutase
E2C04_RS17040	COG1960	acyl-CoA dehydrogenase activity
E2C04_RS17095	COG1959	2 iron, 2 sulfur cluster binding
E2C04_RS17115	COG0531	amino acid
E2C04_RS17185	COG1522	sequence-specific DNA binding
E2C04_RS17230	COG1595	DNA-templated transcription, initiation
E2C04_RS17265	COG1595	DNA-templated transcription, initiation
E2C04_RS17290	COG0359	binds to the 23S rRNA
E2C04_RS17295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2C04_RS17305	COG0360	Binds together with S18 to 16S ribosomal RNA
E2C04_RS17310	COG0515	serine threonine protein kinase
E2C04_RS17325	COG0604	alcohol dehydrogenase
E2C04_RS17365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E2C04_RS17375	COG1260	myo-inositol-1-phosphate synthase
E2C04_RS17380	COG0617	tRNA 3'-terminal CCA addition
E2C04_RS17400	COG1595	DNA-templated transcription, initiation
E2C04_RS17410	COG0492	ferredoxin-NADP+ reductase activity
E2C04_RS17415	COG3118	belongs to the thioredoxin family
E2C04_RS17440	COG1192	Involved in chromosome partitioning
E2C04_RS17445	COG0357	Ribosomal RNA small subunit methyltransferase G
E2C04_RS17455	COG0706	membrane insertase activity
E2C04_RS17460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2C04_RS17465	COG0594	ribonuclease P activity
E2C04_RS17470	COG0230	Belongs to the bacterial ribosomal protein bL34 family