locus-tag	class	description
EXE57_RS00015	COG1233	COG1233 Phytoene dehydrogenase and related
EXE57_RS00045	COG0587	DNA-directed DNA polymerase activity
EXE57_RS00050	COG2264	protein methyltransferase activity
EXE57_RS00055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXE57_RS00075	COG0714	Associated with various cellular activities
EXE57_RS00080	COG2001	Belongs to the MraZ family
EXE57_RS00085	COG0275	rRNA processing
EXE57_RS00095	COG0768	penicillin binding
EXE57_RS00100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXE57_RS00105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXE57_RS00110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXE57_RS00115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXE57_RS00120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXE57_RS00130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXE57_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXE57_RS00140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXE57_RS00145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXE57_RS00150	COG1496	oxidoreductase activity
EXE57_RS00160	COG1799	cell septum assembly
EXE57_RS00175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXE57_RS00180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXE57_RS00200	COG0587	DNA-directed DNA polymerase activity
EXE57_RS00215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXE57_RS00225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EXE57_RS00230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EXE57_RS00235	COG0131	Imidazoleglycerol-phosphate dehydratase
EXE57_RS00240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXE57_RS00245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXE57_RS00250	COG0107	imidazoleglycerol-phosphate synthase activity
EXE57_RS00255	COG1113	amino acid transport
EXE57_RS00260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXE57_RS00265	COG0765	amino acid transport
EXE57_RS00275	COG1132	(ABC) transporter
EXE57_RS00280	COG1132	(ABC) transporter
EXE57_RS00285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EXE57_RS00300	COG0134	indole-3-glycerol-phosphate synthase activity
EXE57_RS00305	COG0133	tryptophan synthase activity
EXE57_RS00310	COG0159	tryptophan synthase activity
EXE57_RS00320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXE57_RS00325	COG0070	glutamate synthase
EXE57_RS00325	COG0069	glutamate synthase activity
EXE57_RS00325	COG0067	glutamate synthase
EXE57_RS00415	COG3119	arylsulfatase activity
EXE57_RS00420	COG2226	methyltransferase
EXE57_RS00430	COG0539	negative regulation of cytoplasmic translation
EXE57_RS00455	COG0237	dephospho-CoA kinase activity
EXE57_RS00475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXE57_RS00495	COG0589	response to stress
EXE57_RS00505	COG0456	acetyltransferase
EXE57_RS00515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXE57_RS00570	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EXE57_RS00570	COG1672	PFAM Archaeal ATPase
EXE57_RS00580	COG0477	Major facilitator Superfamily
EXE57_RS00590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXE57_RS00610	COG2132	Multicopper oxidase
EXE57_RS00620	COG1435	thymidine kinase activity
EXE57_RS00640	COG2860	membrane
EXE57_RS00655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXE57_RS00680	COG0756	dUTP diphosphatase activity
EXE57_RS00705	COG0569	domain protein
EXE57_RS00710	COG0531	amino acid
EXE57_RS00715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXE57_RS00745	COG0604	alcohol dehydrogenase
EXE57_RS00755	COG2197	response regulator
EXE57_RS00790	COG2409	Drug exporters of the RND superfamily
EXE57_RS00800	COG1063	alcohol dehydrogenase
EXE57_RS00810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXE57_RS00810	COG1215	transferase activity, transferring glycosyl groups
EXE57_RS00825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXE57_RS00860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXE57_RS00865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXE57_RS00890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXE57_RS00900	COG0747	negative chemotaxis
EXE57_RS00905	COG0601	transmembrane transport
EXE57_RS00910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXE57_RS00920	COG4608	Belongs to the ABC transporter superfamily
EXE57_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS00980	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXE57_RS00985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXE57_RS00990	COG1309	transcriptional regulator
EXE57_RS01005	COG1946	Acyl-CoA thioesterase
EXE57_RS01020	COG2936	dipeptidyl-peptidase activity
EXE57_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS01035	COG0183	Belongs to the thiolase family
EXE57_RS01050	COG1793	dna ligase
EXE57_RS01055	COG3483	tryptophan 2,3-dioxygenase activity
EXE57_RS01065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXE57_RS01075	COG0556	nucleotide-excision repair
EXE57_RS01105	COG0492	ferredoxin-NADP+ reductase activity
EXE57_RS01110	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS01130	COG1063	alcohol dehydrogenase
EXE57_RS01145	COG2318	DinB family
EXE57_RS01160	COG2318	DinB family
EXE57_RS01190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXE57_RS01205	COG0322	excinuclease ABC activity
EXE57_RS01210	COG1660	Displays ATPase and GTPase activities
EXE57_RS01215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXE57_RS01220	COG1481	regulation of sporulation
EXE57_RS01225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXE57_RS01230	COG0126	phosphoglycerate kinase activity
EXE57_RS01235	COG0149	triose-phosphate isomerase activity
EXE57_RS01240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXE57_RS01255	COG0363	glucosamine-6-phosphate deaminase activity
EXE57_RS01270	COG0166	Belongs to the GPI family
EXE57_RS01275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EXE57_RS01285	COG0109	protoheme IX farnesyltransferase activity
EXE57_RS01300	COG1131	(ABC) transporter
EXE57_RS01310	COG4585	Histidine kinase
EXE57_RS01355	COG2146	nitrite reductase [NAD(P)H] activity
EXE57_RS01360	COG0396	ATPase activity
EXE57_RS01365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXE57_RS01370	COG0822	iron-sulfur transferase activity
EXE57_RS01375	COG2151	metal-sulfur cluster biosynthetic enzyme
EXE57_RS01405	COG1131	(ABC) transporter
EXE57_RS01425	COG0488	(ABC) transporter
EXE57_RS01430	COG1024	Enoyl-CoA hydratase
EXE57_RS01435	COG1132	(ABC) transporter
EXE57_RS01450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXE57_RS01465	COG3360	Dodecin
EXE57_RS01480	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXE57_RS01480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXE57_RS01485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXE57_RS01490	COG2267	carboxylic ester hydrolase activity
EXE57_RS01495	COG0189	ligase activity
EXE57_RS01495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXE57_RS01500	COG4242	Belongs to the peptidase S51 family
EXE57_RS01510	COG3830	Belongs to the UPF0237 family
EXE57_RS01510	COG0560	Phosphoserine phosphatase
EXE57_RS01525	COG1119	ATPase activity
EXE57_RS01565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EXE57_RS01575	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS01585	COG0531	amino acid
EXE57_RS01610	COG1131	(ABC) transporter
EXE57_RS01645	COG1881	PFAM PEBP family protein
EXE57_RS01650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXE57_RS01650	COG1648	precorrin-2 dehydrogenase activity
EXE57_RS01670	COG1404	Belongs to the peptidase S8 family
EXE57_RS01685	COG0242	peptide deformylase activity
EXE57_RS01690	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS01695	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS01755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXE57_RS01765	COG0667	Aldo Keto reductase
EXE57_RS01770	COG1968	undecaprenyl-diphosphatase activity
EXE57_RS01780	COG0598	Magnesium transport protein CorA
EXE57_RS01800	COG0215	cysteine-tRNA ligase activity
EXE57_RS01810	COG1410	methionine synthase
EXE57_RS01810	COG0646	methionine synthase
EXE57_RS01840	COG2197	response regulator
EXE57_RS01850	COG0517	IMP dehydrogenase activity
EXE57_RS01850	COG1994	Peptidase M50
EXE57_RS01860	COG1222	aaa ATPase
EXE57_RS01885	COG2226	methyltransferase
EXE57_RS01890	COG4122	O-methyltransferase activity
EXE57_RS01900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EXE57_RS01905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EXE57_RS01930	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS01940	COG0726	polysaccharide deacetylase
EXE57_RS01950	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EXE57_RS01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXE57_RS01975	COG0805	protein transport
EXE57_RS01985	COG1597	lipid kinase activity
EXE57_RS01995	COG0702	epimerase
EXE57_RS02000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXE57_RS02030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXE57_RS02035	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS02040	COG0726	polysaccharide deacetylase
EXE57_RS02055	COG1132	(ABC) transporter
EXE57_RS02070	COG0297	glycogen (starch) synthase activity
EXE57_RS02080	COG0489	protein tyrosine kinase activity
EXE57_RS02080	COG3206	protein involved in exopolysaccharide biosynthesis
EXE57_RS02095	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS02115	COG2197	response regulator
EXE57_RS02155	COG0604	alcohol dehydrogenase
EXE57_RS02160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXE57_RS02165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS02170	COG1607	acyl-coa hydrolase
EXE57_RS02180	COG0463	Glycosyl transferase, family 2
EXE57_RS02185	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXE57_RS02210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EXE57_RS02240	COG2235	arginine
EXE57_RS02245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXE57_RS02255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EXE57_RS02285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXE57_RS02295	COG0420	3'-5' exonuclease activity
EXE57_RS02300	COG0419	ATPase involved in DNA repair
EXE57_RS02330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXE57_RS02330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXE57_RS02405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXE57_RS02415	COG0477	Major facilitator Superfamily
EXE57_RS02425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EXE57_RS02500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXE57_RS02550	COG1160	GTP binding
EXE57_RS02555	COG0204	Acyl-transferase
EXE57_RS02555	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS02560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXE57_RS02570	COG4401	Chorismate mutase type I
EXE57_RS02580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXE57_RS02620	COG0686	Belongs to the AlaDH PNT family
EXE57_RS02625	COG0494	nUDIX hydrolase
EXE57_RS02635	COG0504	CTP synthase activity
EXE57_RS02650	COG0497	DNA recombination
EXE57_RS02655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EXE57_RS02665	COG0647	UMP catabolic process
EXE57_RS02695	COG2094	Belongs to the DNA glycosylase MPG family
EXE57_RS02700	COG0165	Argininosuccinate lyase
EXE57_RS02705	COG0137	argininosuccinate synthase activity
EXE57_RS02710	COG1438	arginine binding
EXE57_RS02715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EXE57_RS02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXE57_RS02725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXE57_RS02730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EXE57_RS02735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXE57_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS02770	COG0072	phenylalanine-tRNA ligase activity
EXE57_RS02770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXE57_RS02775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXE57_RS02780	COG3739	integral membrane protein
EXE57_RS02790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXE57_RS02795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXE57_RS02800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EXE57_RS02805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EXE57_RS02830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXE57_RS02830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXE57_RS02840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXE57_RS02845	COG0140	phosphoribosyl-ATP diphosphatase activity
EXE57_RS02850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EXE57_RS02855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXE57_RS02855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXE57_RS02870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXE57_RS02905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXE57_RS02910	COG0242	peptide deformylase activity
EXE57_RS02925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXE57_RS02935	COG1758	RNA polymerase activity
EXE57_RS02940	COG0194	GDP metabolic process
EXE57_RS02955	COG0284	orotidine-5'-phosphate decarboxylase activity
EXE57_RS02970	COG0167	dihydroorotate dehydrogenase activity
EXE57_RS02975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXE57_RS02980	COG0505	Belongs to the CarA family
EXE57_RS02985	COG1126	abc transporter atp-binding protein
EXE57_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXE57_RS03010	COG0488	(ABC) transporter
EXE57_RS03020	COG3973	AAA domain
EXE57_RS03035	COG2032	superoxide dismutase activity
EXE57_RS03045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXE57_RS03050	COG0540	Belongs to the ATCase OTCase family
EXE57_RS03055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXE57_RS03070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXE57_RS03080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXE57_RS03085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXE57_RS03115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXE57_RS03120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXE57_RS03125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXE57_RS03130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EXE57_RS03145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXE57_RS03150	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXE57_RS03155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXE57_RS03185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXE57_RS03190	COG0124	histidyl-tRNA synthetase
EXE57_RS03200	COG1196	nuclear chromosome segregation
EXE57_RS03205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXE57_RS03210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXE57_RS03215	COG1862	Preprotein translocase
EXE57_RS03220	COG2255	four-way junction helicase activity
EXE57_RS03225	COG0632	four-way junction helicase activity
EXE57_RS03230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EXE57_RS03240	COG0217	transcriptional regulatory protein
EXE57_RS03245	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXE57_RS03250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXE57_RS03255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXE57_RS03285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXE57_RS03335	COG3654	unkown
EXE57_RS03340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EXE57_RS03345	COG2239	Acts as a magnesium transporter
EXE57_RS03360	COG0589	response to stress
EXE57_RS03375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXE57_RS03385	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS03390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXE57_RS03395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXE57_RS03400	COG0175	sulfate reduction
EXE57_RS03425	COG2326	polyphosphate kinase activity
EXE57_RS03440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXE57_RS03445	COG5002	protein histidine kinase activity
EXE57_RS03450	COG0745	RESPONSE REGULATOR receiver
EXE57_RS03465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXE57_RS03490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EXE57_RS03495	COG0477	Major facilitator Superfamily
EXE57_RS03515	COG0842	Transport permease protein
EXE57_RS03525	COG1131	(ABC) transporter
EXE57_RS03540	COG3152	Membrane
EXE57_RS03555	COG1201	RNA secondary structure unwinding
EXE57_RS03560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EXE57_RS03565	COG1396	sequence-specific DNA binding
EXE57_RS03570	COG1058	Belongs to the CinA family
EXE57_RS03570	COG1546	Belongs to the CinA family
EXE57_RS03575	COG3387	PFAM Glycoside hydrolase 15-related
EXE57_RS03595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXE57_RS03605	COG1674	ftsk spoiiie
EXE57_RS03610	COG2205	protein histidine kinase activity
EXE57_RS03615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXE57_RS03620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXE57_RS03625	COG3942	CHAP domain
EXE57_RS03630	COG3340	Belongs to the peptidase S51 family
EXE57_RS03640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EXE57_RS03645	COG0384	phenazine biosynthesis protein PhzF
EXE57_RS03660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXE57_RS03665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXE57_RS03670	COG2197	response regulator
EXE57_RS03680	COG2197	response regulator
EXE57_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXE57_RS03695	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXE57_RS03710	COG0321	lipoyl(octanoyl) transferase activity
EXE57_RS03720	COG1309	transcriptional regulator
EXE57_RS03725	COG1131	(ABC) transporter
EXE57_RS03735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXE57_RS03745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EXE57_RS03750	COG2909	trisaccharide binding
EXE57_RS03775	COG3119	arylsulfatase activity
EXE57_RS03790	COG0174	glutamine synthetase
EXE57_RS03815	COG2197	response regulator
EXE57_RS03815	COG3903	Transcriptional regulator
EXE57_RS03830	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EXE57_RS03845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXE57_RS03850	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXE57_RS03860	COG3842	ATPase activity
EXE57_RS03865	COG4638	Rieske (2fe-2S)
EXE57_RS03875	COG1309	transcriptional regulator
EXE57_RS03885	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS03890	COG1024	Enoyl-CoA hydratase
EXE57_RS03895	COG3119	arylsulfatase activity
EXE57_RS03900	COG0747	negative chemotaxis
EXE57_RS03910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXE57_RS03920	COG3246	L-lysine catabolic process to acetate
EXE57_RS03925	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXE57_RS03945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXE57_RS03955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXE57_RS03985	COG3588	fructose-bisphosphate aldolase
EXE57_RS04010	COG0628	permease
EXE57_RS04025	COG2197	response regulator
EXE57_RS04035	COG2205	protein histidine kinase activity
EXE57_RS04050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXE57_RS04080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXE57_RS04080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXE57_RS04090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EXE57_RS04095	COG0512	Glutamine amidotransferase of anthranilate synthase
EXE57_RS04100	COG0174	glutamine synthetase
EXE57_RS04110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EXE57_RS04165	COG1404	Belongs to the peptidase S8 family
EXE57_RS04165	COG4412	M6 family metalloprotease domain protein
EXE57_RS04180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXE57_RS04215	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EXE57_RS04220	COG3022	response to hydroperoxide
EXE57_RS04230	COG1595	DNA-templated transcription, initiation
EXE57_RS04260	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS04270	COG5002	protein histidine kinase activity
EXE57_RS04270	COG3850	Histidine kinase
EXE57_RS04275	COG0745	RESPONSE REGULATOR receiver
EXE57_RS04285	COG0515	serine threonine protein kinase
EXE57_RS04310	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS04320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EXE57_RS04340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXE57_RS04345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXE57_RS04350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXE57_RS04395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EXE57_RS04400	COG0515	serine threonine protein kinase
EXE57_RS04420	COG1309	transcriptional regulator
EXE57_RS04425	COG2409	Drug exporters of the RND superfamily
EXE57_RS04465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXE57_RS04510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EXE57_RS04530	COG0423	glycine-tRNA ligase activity
EXE57_RS04540	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXE57_RS04540	COG3443	Belongs to the bacterial solute-binding protein 9 family
EXE57_RS04545	COG1121	(ABC) transporter
EXE57_RS04550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXE57_RS04560	COG5002	protein histidine kinase activity
EXE57_RS04565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EXE57_RS04570	COG1381	Involved in DNA repair and RecF pathway recombination
EXE57_RS04580	COG5002	protein histidine kinase activity
EXE57_RS04585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXE57_RS04610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXE57_RS04620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EXE57_RS04650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXE57_RS04660	COG0537	adenosine 5'-monophosphoramidase activity
EXE57_RS04690	COG0484	heat shock protein binding
EXE57_RS04695	COG1420	regulation of RNA biosynthetic process
EXE57_RS04700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXE57_RS04730	COG1022	Amp-dependent synthetase and ligase
EXE57_RS04740	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
EXE57_RS04775	COG0268	Binds directly to 16S ribosomal RNA
EXE57_RS04790	COG1555	photosystem II stabilization
EXE57_RS04795	COG1307	EDD domain protein, DegV family
EXE57_RS04800	COG0495	leucyl-tRNA aminoacylation
EXE57_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS04825	COG0406	alpha-ribazole phosphatase activity
EXE57_RS04830	COG0799	negative regulation of ribosome biogenesis
EXE57_RS04835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXE57_RS04840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXE57_RS04850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXE57_RS04855	COG2086	electron transfer activity
EXE57_RS04875	COG0058	SHG alpha-glucan phosphorylase activity
EXE57_RS04880	COG0366	Alpha amylase catalytic
EXE57_RS04890	COG3281	Trehalose synthase
EXE57_RS04895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXE57_RS04910	COG0574	Belongs to the PEP-utilizing enzyme family
EXE57_RS04910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EXE57_RS04930	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS04930	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS04935	COG1846	Transcriptional regulator
EXE57_RS04945	COG4251	negative regulation of phosphorylation
EXE57_RS04950	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS04955	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS04965	COG0183	Belongs to the thiolase family
EXE57_RS04970	COG0346	lactoylglutathione lyase activity
EXE57_RS04985	COG0628	permease
EXE57_RS05000	COG0596	Alpha beta hydrolase
EXE57_RS05025	COG2271	Major facilitator Superfamily
EXE57_RS05050	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXE57_RS05060	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EXE57_RS05070	COG5002	protein histidine kinase activity
EXE57_RS05080	COG1528	Iron-storage protein
EXE57_RS05100	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS05100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS05120	COG0738	Major facilitator superfamily
EXE57_RS05130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXE57_RS05135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXE57_RS05140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXE57_RS05145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXE57_RS05155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXE57_RS05160	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXE57_RS05165	COG0356	it plays a direct role in the translocation of protons across the membrane
EXE57_RS05180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXE57_RS05190	COG2890	protein-(glutamine-N5) methyltransferase activity
EXE57_RS05195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXE57_RS05200	COG0254	rRNA binding
EXE57_RS05205	COG1215	transferase activity, transferring glycosyl groups
EXE57_RS05225	COG0083	homoserine kinase activity
EXE57_RS05230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EXE57_RS05235	COG0460	homoserine dehydrogenase
EXE57_RS05240	COG0019	diaminopimelate decarboxylase activity
EXE57_RS05245	COG0018	arginyl-trna synthetase
EXE57_RS05265	COG0567	Dehydrogenase, E1 component
EXE57_RS05265	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXE57_RS05315	COG0604	alcohol dehydrogenase
EXE57_RS05340	COG2172	sigma factor antagonist activity
EXE57_RS05385	COG1595	DNA-templated transcription, initiation
EXE57_RS05395	COG2135	peptidase activity
EXE57_RS05405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXE57_RS05410	COG1162	GTPase activity
EXE57_RS05425	COG0483	inositol monophosphate 1-phosphatase activity
EXE57_RS05430	COG0517	IMP dehydrogenase activity
EXE57_RS05430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXE57_RS05430	COG0617	tRNA 3'-terminal CCA addition
EXE57_RS05445	COG2501	S4 domain
EXE57_RS05450	COG2733	membrane
EXE57_RS05455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXE57_RS05485	COG0492	ferredoxin-NADP+ reductase activity
EXE57_RS05515	COG0477	Major facilitator Superfamily
EXE57_RS05525	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS05530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXE57_RS05535	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXE57_RS05540	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXE57_RS05545	COG0493	'glutamate synthase
EXE57_RS05595	COG0277	FAD linked oxidase domain protein
EXE57_RS05600	COG2181	nitrate reductase activity
EXE57_RS05600	COG0247	lactate metabolic process
EXE57_RS05625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EXE57_RS05625	COG1017	nitric oxide dioxygenase activity
EXE57_RS05630	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXE57_RS05665	COG4585	Histidine kinase
EXE57_RS05670	COG2197	response regulator
EXE57_RS05685	COG1063	alcohol dehydrogenase
EXE57_RS05705	COG3409	Peptidoglycan-binding domain 1 protein
EXE57_RS05705	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXE57_RS05795	COG1401	restriction endodeoxyribonuclease activity
EXE57_RS05815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXE57_RS05950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXE57_RS06030	COG1615	UPF0182 protein
EXE57_RS06040	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXE57_RS06070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXE57_RS06070	COG1796	DNA polymerase
EXE57_RS06115	COG2816	NAD+ diphosphatase activity
EXE57_RS06120	COG0813	purine-nucleoside phosphorylase activity
EXE57_RS06125	COG0210	DNA helicase
EXE57_RS06145	COG0549	Belongs to the carbamate kinase family
EXE57_RS06150	COG3263	regulation of cellular component size
EXE57_RS06160	COG2197	response regulator
EXE57_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS06190	COG0204	Acyl-transferase
EXE57_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS06225	COG2233	PERMEase
EXE57_RS06260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXE57_RS06265	COG1304	FMN binding
EXE57_RS06285	COG1309	transcriptional regulator
EXE57_RS06305	COG0513	Belongs to the DEAD box helicase family
EXE57_RS06315	COG1192	Involved in chromosome partitioning
EXE57_RS06325	COG2095	MarC family integral membrane protein
EXE57_RS06370	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS06415	COG2239	Acts as a magnesium transporter
EXE57_RS06435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXE57_RS06450	COG1309	transcriptional regulator
EXE57_RS06460	COG0653	protein targeting
EXE57_RS06465	COG3214	Protein conserved in bacteria
EXE57_RS06470	COG2197	response regulator
EXE57_RS06475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EXE57_RS06485	COG5401	PFAM Sporulation and spore germination
EXE57_RS06490	COG5000	phosphorelay sensor kinase activity
EXE57_RS06490	COG5002	protein histidine kinase activity
EXE57_RS06500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EXE57_RS06505	COG2354	Protein conserved in bacteria
EXE57_RS06510	COG2040	homocysteine
EXE57_RS06520	COG2835	tetraacyldisaccharide 4'-kinase activity
EXE57_RS06555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXE57_RS06560	COG0778	Nitroreductase
EXE57_RS06560	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EXE57_RS06570	COG0662	Cupin 2, conserved barrel domain protein
EXE57_RS06570	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EXE57_RS06595	COG1216	Glycosyl transferase, family 2
EXE57_RS06610	COG1216	Glycosyl transferase, family 2
EXE57_RS06615	COG1316	TRANSCRIPTIONal
EXE57_RS06625	COG1607	acyl-coa hydrolase
EXE57_RS06630	COG1316	TRANSCRIPTIONal
EXE57_RS06640	COG2050	protein possibly involved in aromatic compounds catabolism
EXE57_RS06660	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXE57_RS06685	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS06690	COG0693	protein deglycase activity
EXE57_RS06695	COG1832	CoA-binding protein
EXE57_RS06700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXE57_RS06730	COG0745	RESPONSE REGULATOR receiver
EXE57_RS06735	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EXE57_RS06750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXE57_RS06760	COG3191	aminopeptidase activity
EXE57_RS06765	COG4941	Belongs to the sigma-70 factor family
EXE57_RS06770	COG3795	YCII-related domain
EXE57_RS06775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXE57_RS06790	COG0424	maF-like protein
EXE57_RS06805	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS06820	COG3842	ATPase activity
EXE57_RS06830	COG4770	biotin carboxylase activity
EXE57_RS06860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXE57_RS06865	COG2226	methyltransferase
EXE57_RS06875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXE57_RS06900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXE57_RS06905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXE57_RS06930	COG3655	Transcriptional regulator
EXE57_RS06960	COG0596	Alpha beta hydrolase
EXE57_RS06965	COG2385	sporulation resulting in formation of a cellular spore
EXE57_RS06970	COG2385	sporulation resulting in formation of a cellular spore
EXE57_RS06995	COG1966	Carbon starvation protein
EXE57_RS07000	COG0667	Aldo Keto reductase
EXE57_RS07035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXE57_RS07040	COG0640	Transcriptional regulator
EXE57_RS07050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXE57_RS07055	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS07060	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS07075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EXE57_RS07100	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXE57_RS07105	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXE57_RS07110	COG3845	ABC transporter
EXE57_RS07115	COG1744	ABC transporter substrate-binding protein PnrA-like
EXE57_RS07120	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EXE57_RS07120	COG1473	amidohydrolase
EXE57_RS07150	COG0584	glycerophosphoryl diester phosphodiesterase
EXE57_RS07190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXE57_RS07195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EXE57_RS07200	COG1414	Transcriptional regulator
EXE57_RS07210	COG2086	electron transfer activity
EXE57_RS07215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXE57_RS07230	COG1053	succinate dehydrogenase
EXE57_RS07235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXE57_RS07255	COG0180	Tryptophanyl-tRNA synthetase
EXE57_RS07260	COG1819	glycosyl
EXE57_RS07265	COG2814	Major facilitator Superfamily
EXE57_RS07270	COG2838	Isocitrate dehydrogenase
EXE57_RS07290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXE57_RS07295	COG0138	bifunctional purine biosynthesis protein purh
EXE57_RS07325	COG0045	succinate-CoA ligase (ADP-forming) activity
EXE57_RS07330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS07330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXE57_RS07335	COG1196	nuclear chromosome segregation
EXE57_RS07335	COG0739	heme binding
EXE57_RS07335	COG0741	lytic transglycosylase activity
EXE57_RS07365	COG0531	amino acid
EXE57_RS07370	COG2197	response regulator
EXE57_RS07395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXE57_RS07410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EXE57_RS07420	COG0402	S-adenosylhomocysteine deaminase activity
EXE57_RS07430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EXE57_RS07440	COG3257	ureidoglycine aminohydrolase activity
EXE57_RS07445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXE57_RS07450	COG2351	hydroxyisourate hydrolase activity
EXE57_RS07470	COG0519	Catalyzes the synthesis of GMP from XMP
EXE57_RS07470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXE57_RS07480	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS07485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXE57_RS07495	COG0702	epimerase
EXE57_RS07505	COG0516	GMP reductase activity
EXE57_RS07530	COG2814	Major facilitator Superfamily
EXE57_RS07545	COG0459	protein refolding
EXE57_RS07550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXE57_RS07570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXE57_RS07585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXE57_RS07595	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EXE57_RS07605	COG0681	Belongs to the peptidase S26 family
EXE57_RS07640	COG0242	peptide deformylase activity
EXE57_RS07645	COG3830	Belongs to the UPF0237 family
EXE57_RS07670	COG0148	phosphopyruvate hydratase activity
EXE57_RS07700	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXE57_RS07705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EXE57_RS07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXE57_RS07725	COG2188	Transcriptional regulator
EXE57_RS07765	COG0193	aminoacyl-tRNA hydrolase activity
EXE57_RS07770	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EXE57_RS07780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EXE57_RS07785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXE57_RS07795	COG1793	dna ligase
EXE57_RS07825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXE57_RS07840	COG3253	May function as heme-dependent peroxidase
EXE57_RS07850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXE57_RS07855	COG0431	NADPH-dependent FMN reductase
EXE57_RS07870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXE57_RS07900	COG1643	Atp-dependent helicase
EXE57_RS07910	COG0745	RESPONSE REGULATOR receiver
EXE57_RS07915	COG2205	protein histidine kinase activity
EXE57_RS07920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXE57_RS07925	COG1309	transcriptional regulator
EXE57_RS07930	COG2072	flavoprotein involved in K transport
EXE57_RS07950	COG4129	membrane
EXE57_RS07985	COG3663	DNA glycosylase
EXE57_RS08000	COG0297	glycogen (starch) synthase activity
EXE57_RS08020	COG3046	protein related to deoxyribodipyrimidine photolyase
EXE57_RS08035	COG1501	Belongs to the glycosyl hydrolase 31 family
EXE57_RS08055	COG5522	Integral membrane protein (intg_mem_TP0381)
EXE57_RS08070	COG0395	ABC-type sugar transport system, permease component
EXE57_RS08090	COG3387	PFAM Glycoside hydrolase 15-related
EXE57_RS08145	COG0584	glycerophosphoryl diester phosphodiesterase
EXE57_RS08150	COG0569	domain protein
EXE57_RS08155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXE57_RS08175	COG4585	Histidine kinase
EXE57_RS08180	COG2197	response regulator
EXE57_RS08200	COG2072	flavoprotein involved in K transport
EXE57_RS08205	COG2197	response regulator
EXE57_RS08220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXE57_RS08225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXE57_RS08255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXE57_RS08265	COG4585	Histidine kinase
EXE57_RS08305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXE57_RS08305	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXE57_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXE57_RS08335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXE57_RS08345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXE57_RS08355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXE57_RS08365	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EXE57_RS08380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXE57_RS08385	COG1929	Belongs to the glycerate kinase type-1 family
EXE57_RS08390	COG1609	Transcriptional regulator
EXE57_RS08415	COG1137	ATPase activity
EXE57_RS08420	COG0673	inositol 2-dehydrogenase activity
EXE57_RS08445	COG1126	abc transporter atp-binding protein
EXE57_RS08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXE57_RS08455	COG0765	amino acid transport
EXE57_RS08460	COG0765	amino acid transport
EXE57_RS08470	COG1937	Protein conserved in bacteria
EXE57_RS08475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXE57_RS08485	COG4106	trans-aconitate 2-methyltransferase activity
EXE57_RS08490	COG1846	Transcriptional regulator
EXE57_RS08495	COG0488	(ABC) transporter
EXE57_RS08500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXE57_RS08505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXE57_RS08510	COG3583	domain protein
EXE57_RS08515	COG0084	hydrolase, TatD family'
EXE57_RS08545	COG2936	dipeptidyl-peptidase activity
EXE57_RS08555	COG0154	amidase activity
EXE57_RS08575	COG1595	DNA-templated transcription, initiation
EXE57_RS08605	COG0315	cyclic pyranopterin monophosphate synthase activity
EXE57_RS08620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXE57_RS08640	COG1970	mechanosensitive ion channel activity
EXE57_RS08670	COG3268	Saccharopine dehydrogenase
EXE57_RS08690	COG0415	Belongs to the DNA photolyase family
EXE57_RS08700	COG0366	Alpha amylase catalytic
EXE57_RS08710	COG0477	Major facilitator Superfamily
EXE57_RS08720	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EXE57_RS08725	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
EXE57_RS08730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXE57_RS08735	COG1256	bacterial-type flagellum assembly
EXE57_RS08735	COG4786	Flagellar basal body rod
EXE57_RS08745	COG1191	sigma factor activity
EXE57_RS08750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXE57_RS08780	COG1677	Flagellar hook-basal body complex protein FliE
EXE57_RS08790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXE57_RS08800	COG1157	protein secretion by the type III secretion system
EXE57_RS08810	COG0741	lytic transglycosylase activity
EXE57_RS08810	COG1196	nuclear chromosome segregation
EXE57_RS08810	COG0739	heme binding
EXE57_RS08835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXE57_RS08855	COG1776	CheC inhibitor of MCP methylation
EXE57_RS08855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXE57_RS08865	COG1338	Plays a role in the flagellum-specific transport system
EXE57_RS08875	COG4791	protein targeting
EXE57_RS08885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXE57_RS08915	COG0259	pyridoxamine-phosphate oxidase activity
EXE57_RS08935	COG4106	trans-aconitate 2-methyltransferase activity
EXE57_RS08940	COG0640	Transcriptional regulator
EXE57_RS08970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EXE57_RS08995	COG0277	FAD linked oxidase domain protein
EXE57_RS09010	COG0204	Acyl-transferase
EXE57_RS09015	COG4638	Rieske (2fe-2S)
EXE57_RS09030	COG4638	Rieske (2fe-2S)
EXE57_RS09035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXE57_RS09045	COG0644	oxidoreductase
EXE57_RS09070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXE57_RS09075	COG0085	RNA polymerase activity
EXE57_RS09080	COG0484	heat shock protein binding
EXE57_RS09120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EXE57_RS09125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EXE57_RS09135	COG0222	ribosome binding
EXE57_RS09140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXE57_RS09145	COG0081	regulation of translation
EXE57_RS09150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXE57_RS09170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXE57_RS09175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EXE57_RS09190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXE57_RS09195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EXE57_RS09205	COG2030	dehydratase
EXE57_RS09210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXE57_RS09235	COG1595	DNA-templated transcription, initiation
EXE57_RS09245	COG0154	amidase activity
EXE57_RS09250	COG2818	Glycosylase
EXE57_RS09265	COG1902	pentaerythritol trinitrate reductase activity
EXE57_RS09285	COG3383	formate dehydrogenase (NAD+) activity
EXE57_RS09295	COG1132	(ABC) transporter
EXE57_RS09300	COG1132	(ABC) transporter
EXE57_RS09340	COG4585	Histidine kinase
EXE57_RS09345	COG2197	response regulator
EXE57_RS09350	COG4152	abc transporter atp-binding protein
EXE57_RS09355	COG1668	transmembrane transport
EXE57_RS09370	COG2814	Major facilitator Superfamily
EXE57_RS09375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EXE57_RS09400	COG1666	GTP binding
EXE57_RS09405	COG3842	ATPase activity
EXE57_RS09410	COG4208	sulfate ABC transporter
EXE57_RS09420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXE57_RS09425	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXE57_RS09425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXE57_RS09430	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXE57_RS09445	COG0142	geranyltranstransferase activity
EXE57_RS09450	COG1007	ATP synthesis coupled electron transport
EXE57_RS09465	COG0713	ATP synthesis coupled electron transport
EXE57_RS09475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXE57_RS09480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXE57_RS09485	COG1034	ATP synthesis coupled electron transport
EXE57_RS09500	COG0649	NAD binding
EXE57_RS09510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXE57_RS09515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXE57_RS09525	COG2226	methyltransferase
EXE57_RS09545	COG1169	isochorismate synthase
EXE57_RS09555	COG0747	negative chemotaxis
EXE57_RS09560	COG0601	transmembrane transport
EXE57_RS09565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXE57_RS09575	COG4608	Belongs to the ABC transporter superfamily
EXE57_RS09595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXE57_RS09600	COG4948	Mandelate Racemase Muconate Lactonizing
EXE57_RS09610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EXE57_RS09610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXE57_RS09615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXE57_RS09625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXE57_RS09665	COG4552	Acetyltransferase involved in intracellular survival and related
EXE57_RS09675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXE57_RS09680	COG1333	cytochrome c biogenesis protein
EXE57_RS09685	COG0785	Cytochrome C biogenesis protein
EXE57_RS09690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXE57_RS09695	COG0406	alpha-ribazole phosphatase activity
EXE57_RS09700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXE57_RS09720	COG0113	porphobilinogen synthase activity
EXE57_RS09725	COG1648	precorrin-2 dehydrogenase activity
EXE57_RS09725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXE57_RS09735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXE57_RS09740	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXE57_RS09750	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS09760	COG1595	DNA-templated transcription, initiation
EXE57_RS09790	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXE57_RS09800	COG0180	Tryptophanyl-tRNA synthetase
EXE57_RS09805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXE57_RS09810	COG0506	proline dehydrogenase activity
EXE57_RS09815	COG0483	inositol monophosphate 1-phosphatase activity
EXE57_RS09830	COG1309	transcriptional regulator
EXE57_RS09835	COG1082	Xylose isomerase domain protein TIM barrel
EXE57_RS09840	COG0248	Ppx GppA phosphatase
EXE57_RS09865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXE57_RS09870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXE57_RS09905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXE57_RS09915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXE57_RS09930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EXE57_RS09935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXE57_RS09960	COG1174	glycine betaine transport
EXE57_RS09965	COG0517	IMP dehydrogenase activity
EXE57_RS09965	COG1125	glycine betaine transport
EXE57_RS09990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXE57_RS09995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXE57_RS10000	COG0302	gtp cyclohydrolase
EXE57_RS10015	COG0037	tRNA processing
EXE57_RS10025	COG2027	D-alanyl-D-alanine carboxypeptidase
EXE57_RS10030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EXE57_RS10050	COG3842	ATPase activity
EXE57_RS10075	COG4214	carbohydrate transport
EXE57_RS10085	COG4213	ABC transporter substrate-binding protein
EXE57_RS10090	COG1940	carbohydrate kinase activity
EXE57_RS10165	COG0583	DNA-binding transcription factor activity
EXE57_RS10175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXE57_RS10180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXE57_RS10185	COG2017	converts alpha-aldose to the beta-anomer
EXE57_RS10190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXE57_RS10190	COG1754	DNA topoisomerase type I activity
EXE57_RS10195	COG2890	protein-(glutamine-N5) methyltransferase activity
EXE57_RS10200	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EXE57_RS10205	COG1366	Belongs to the anti-sigma-factor antagonist family
EXE57_RS10210	COG1205	dead DEAH box helicase
EXE57_RS10210	COG1111	helicase
EXE57_RS10275	COG3275	phosphorelay sensor kinase activity
EXE57_RS10280	COG3279	Response regulator of the LytR AlgR family
EXE57_RS10290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXE57_RS10305	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXE57_RS10310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXE57_RS10315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EXE57_RS10330	COG0494	nUDIX hydrolase
EXE57_RS10335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXE57_RS10340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXE57_RS10355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXE57_RS10370	COG1595	DNA-templated transcription, initiation
EXE57_RS10430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXE57_RS10440	COG1408	metallophosphoesterase
EXE57_RS10470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXE57_RS10475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXE57_RS10520	COG1674	ftsk spoiiie
EXE57_RS10540	COG3263	regulation of cellular component size
EXE57_RS10555	COG0542	response to heat
EXE57_RS10585	COG3708	Transcriptional regulator
EXE57_RS10585	COG2207	Transcriptional regulator
EXE57_RS10600	COG0590	tRNA wobble adenosine to inosine editing
EXE57_RS10610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EXE57_RS10615	COG2205	protein histidine kinase activity
EXE57_RS10640	COG3833	ABC-type maltose transport systems, permease component
EXE57_RS10645	COG1175	transmembrane transport
EXE57_RS10655	COG1609	Transcriptional regulator
EXE57_RS10665	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS10710	COG2409	Drug exporters of the RND superfamily
EXE57_RS10735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXE57_RS10775	COG1074	ATP-dependent DNA helicase activity
EXE57_RS10780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EXE57_RS10790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EXE57_RS10815	COG0730	response to heat
EXE57_RS10820	COG1823	symporter activity
EXE57_RS10840	COG2755	lipolytic protein G-D-S-L family
EXE57_RS10860	COG2197	response regulator
EXE57_RS10900	COG0745	RESPONSE REGULATOR receiver
EXE57_RS10935	COG3795	YCII-related domain
EXE57_RS10965	COG0076	glutamate decarboxylase activity
EXE57_RS10980	COG0640	Transcriptional regulator
EXE57_RS11030	COG2197	response regulator
EXE57_RS11035	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EXE57_RS11080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXE57_RS11110	COG0561	phosphatase activity
EXE57_RS11120	COG0561	phosphatase activity
EXE57_RS11125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXE57_RS11145	COG1803	Methylglyoxal synthase
EXE57_RS11145	COG1597	lipid kinase activity
EXE57_RS11175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EXE57_RS11185	COG2235	arginine
EXE57_RS11190	COG0653	protein targeting
EXE57_RS11205	COG1136	(ABC) transporter
EXE57_RS11205	COG0577	efflux transmembrane transporter activity
EXE57_RS11245	COG0586	Pfam SNARE associated Golgi protein
EXE57_RS11260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EXE57_RS11270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EXE57_RS11295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXE57_RS11305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXE57_RS11310	COG1174	glycine betaine transport
EXE57_RS11320	COG1174	glycine betaine transport
EXE57_RS11335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXE57_RS11345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXE57_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXE57_RS11390	COG0514	ATP-dependent DNA helicase (RecQ)
EXE57_RS11420	COG3590	peptidase
EXE57_RS11440	COG0477	Major facilitator Superfamily
EXE57_RS11450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXE57_RS11470	COG0733	neurotransmitter:sodium symporter activity
EXE57_RS11480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXE57_RS11510	COG0386	Belongs to the glutathione peroxidase family
EXE57_RS11520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EXE57_RS11540	COG1937	Protein conserved in bacteria
EXE57_RS11560	COG1802	Transcriptional regulator
EXE57_RS11595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXE57_RS11605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXE57_RS11615	COG0277	FAD linked oxidase domain protein
EXE57_RS11620	COG0471	metal ion transport
EXE57_RS11650	COG1131	(ABC) transporter
EXE57_RS11655	COG3559	Exporter of polyketide antibiotics
EXE57_RS11665	COG1716	ATPase activity
EXE57_RS11685	COG0768	penicillin binding
EXE57_RS11690	COG0515	serine threonine protein kinase
EXE57_RS11695	COG0515	serine threonine protein kinase
EXE57_RS11740	COG0457	Tetratricopeptide repeat
EXE57_RS11740	COG0705	Rhomboid family
EXE57_RS11745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXE57_RS11755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXE57_RS11770	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EXE57_RS11775	COG0515	serine threonine protein kinase
EXE57_RS11815	COG0433	COG0433 Predicted ATPase
EXE57_RS11815	COG1674	ftsk spoiiie
EXE57_RS11840	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EXE57_RS11840	COG1672	PFAM Archaeal ATPase
EXE57_RS11850	COG2814	Major facilitator Superfamily
EXE57_RS11870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXE57_RS11880	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EXE57_RS11885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXE57_RS11890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXE57_RS11895	COG0592	DNA-directed DNA polymerase activity
EXE57_RS11900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXE57_RS11905	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXE57_RS11910	COG0594	ribonuclease P activity
EXE57_RS11920	COG0706	membrane insertase activity
EXE57_RS11930	COG0357	Ribosomal RNA small subunit methyltransferase G
EXE57_RS11935	COG1192	Involved in chromosome partitioning
EXE57_RS11940	COG1475	DNA binding
EXE57_RS11960	COG3118	belongs to the thioredoxin family
EXE57_RS11965	COG0492	ferredoxin-NADP+ reductase activity
EXE57_RS11975	COG1595	DNA-templated transcription, initiation
EXE57_RS11995	COG0617	tRNA 3'-terminal CCA addition
EXE57_RS12025	COG1260	myo-inositol-1-phosphate synthase
EXE57_RS12035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXE57_RS12060	COG0360	Binds together with S18 to 16S ribosomal RNA
EXE57_RS12065	COG0629	single-stranded DNA binding
EXE57_RS12070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EXE57_RS12075	COG0359	binds to the 23S rRNA
EXE57_RS12085	COG0534	Mate efflux family protein
EXE57_RS12090	COG0305	Participates in initiation and elongation during chromosome replication
EXE57_RS12095	COG2197	response regulator
EXE57_RS12100	COG4585	Histidine kinase
EXE57_RS12105	COG1131	(ABC) transporter
EXE57_RS12115	COG0300	oxidoreductase activity
EXE57_RS12155	COG2031	fatty acid transporter
EXE57_RS12170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EXE57_RS12180	COG0667	Aldo Keto reductase
EXE57_RS12215	COG0456	acetyltransferase
EXE57_RS12225	COG1254	Belongs to the acylphosphatase family
EXE57_RS12240	COG1132	(ABC) transporter
EXE57_RS12245	COG0515	serine threonine protein kinase
EXE57_RS12250	COG5002	protein histidine kinase activity
EXE57_RS12250	COG3850	Histidine kinase
EXE57_RS12280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EXE57_RS12300	COG0346	lactoylglutathione lyase activity
EXE57_RS12310	COG1733	regulation of RNA biosynthetic process
EXE57_RS12365	COG0010	Belongs to the arginase family
EXE57_RS12390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXE57_RS12395	COG2610	gluconate transmembrane transporter activity
EXE57_RS12400	COG1794	racemase activity, acting on amino acids and derivatives
EXE57_RS12445	COG4067	protein conserved in archaea
EXE57_RS12445	COG0189	ligase activity
EXE57_RS12450	COG0569	domain protein
EXE57_RS12450	COG0189	ligase activity
EXE57_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS12465	COG3321	synthase
EXE57_RS12465	COG0604	alcohol dehydrogenase
EXE57_RS12525	COG4941	Belongs to the sigma-70 factor family
EXE57_RS12550	COG1476	TRANSCRIPTIONal
EXE57_RS12555	COG0454	-acetyltransferase
EXE57_RS12555	COG0456	acetyltransferase
EXE57_RS12565	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS12580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EXE57_RS12590	COG2755	lipolytic protein G-D-S-L family
EXE57_RS12650	COG1741	Belongs to the pirin family
EXE57_RS12660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXE57_RS12665	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXE57_RS12665	COG1902	pentaerythritol trinitrate reductase activity
EXE57_RS12680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXE57_RS12710	COG0702	epimerase
EXE57_RS12720	COG0183	Belongs to the thiolase family
EXE57_RS12730	COG1131	(ABC) transporter
EXE57_RS12745	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS12765	COG2318	DinB family
EXE57_RS12775	COG1695	Transcriptional regulator
EXE57_RS12780	COG1136	(ABC) transporter
EXE57_RS12790	COG2409	Drug exporters of the RND superfamily
EXE57_RS12810	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS12820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXE57_RS12840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EXE57_RS12870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EXE57_RS12875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EXE57_RS12890	COG1595	DNA-templated transcription, initiation
EXE57_RS12905	COG1024	Enoyl-CoA hydratase
EXE57_RS12910	COG1595	DNA-templated transcription, initiation
EXE57_RS12935	COG3119	arylsulfatase activity
EXE57_RS12945	COG0512	Glutamine amidotransferase of anthranilate synthase
EXE57_RS12945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXE57_RS12955	COG0745	RESPONSE REGULATOR receiver
EXE57_RS12960	COG3001	Fructosamine kinase
EXE57_RS12965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXE57_RS12970	COG1950	PFAM Membrane protein of
EXE57_RS12985	COG0745	RESPONSE REGULATOR receiver
EXE57_RS12990	COG2205	protein histidine kinase activity
EXE57_RS13010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EXE57_RS13015	COG0435	Glutathione S-transferase
EXE57_RS13020	COG1230	cation diffusion facilitator family transporter
EXE57_RS13030	COG2197	response regulator
EXE57_RS13035	COG4585	Histidine kinase
EXE57_RS13050	COG0022	dehydrogenase e1 component
EXE57_RS13055	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXE57_RS13070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXE57_RS13075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXE57_RS13080	COG2610	gluconate transmembrane transporter activity
EXE57_RS13085	COG3395	kinase activity
EXE57_RS13090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EXE57_RS13095	COG1349	DNA-binding transcription factor activity
EXE57_RS13105	COG1595	DNA-templated transcription, initiation
EXE57_RS13145	COG1309	transcriptional regulator
EXE57_RS13150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXE57_RS13155	COG1609	Transcriptional regulator
EXE57_RS13190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXE57_RS13220	COG1064	alcohol dehydrogenase
EXE57_RS13240	COG2084	Dehydrogenase
EXE57_RS13260	COG2010	Cytochrome c
EXE57_RS13260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EXE57_RS13270	COG1802	Transcriptional regulator
EXE57_RS13280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXE57_RS13285	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXE57_RS13295	COG1802	Transcriptional regulator
EXE57_RS13310	COG0683	leucine binding
EXE57_RS13325	COG3842	ATPase activity
EXE57_RS13335	COG2409	Drug exporters of the RND superfamily
EXE57_RS13345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXE57_RS13375	COG0300	oxidoreductase activity
EXE57_RS13400	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS13430	COG0717	Belongs to the dCTP deaminase family
EXE57_RS13440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXE57_RS13445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXE57_RS13450	COG1120	ATPase activity
EXE57_RS13485	COG0247	lactate metabolic process
EXE57_RS13485	COG2181	nitrate reductase activity
EXE57_RS13515	COG2986	histidine ammonia-lyase
EXE57_RS13520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXE57_RS13535	COG2301	Belongs to the HpcH HpaI aldolase family
EXE57_RS13540	COG2301	Belongs to the HpcH HpaI aldolase family
EXE57_RS13550	COG2197	response regulator
EXE57_RS13560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXE57_RS13570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXE57_RS13575	COG1228	amidohydrolase
EXE57_RS13580	COG1228	amidohydrolase
EXE57_RS13585	COG1672	PFAM Archaeal ATPase
EXE57_RS13585	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EXE57_RS13625	COG0656	L-ascorbic acid biosynthetic process
EXE57_RS13635	COG0443	Heat shock 70 kDa protein
EXE57_RS13640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EXE57_RS13645	COG0484	heat shock protein binding
EXE57_RS13650	COG0789	Transcriptional regulator
EXE57_RS13670	COG1357	PFAM Pentapeptide repeats (8 copies)
EXE57_RS13675	COG4399	Belongs to the UPF0754 family
EXE57_RS13685	COG2201	protein-glutamate methylesterase activity
EXE57_RS13690	COG0542	response to heat
EXE57_RS13700	COG2318	DinB family
EXE57_RS13820	COG0577	efflux transmembrane transporter activity
EXE57_RS13820	COG1136	(ABC) transporter
EXE57_RS13825	COG1136	(ABC) transporter
EXE57_RS13845	COG0191	fructose-bisphosphate aldolase activity
EXE57_RS13880	COG0586	Pfam SNARE associated Golgi protein
EXE57_RS13885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXE57_RS13900	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXE57_RS13915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EXE57_RS13930	COG0395	ABC-type sugar transport system, permease component
EXE57_RS13935	COG1175	transmembrane transport
EXE57_RS13945	COG0151	Belongs to the GarS family
EXE57_RS13950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXE57_RS13985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXE57_RS13995	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS14005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXE57_RS14010	COG0047	phosphoribosylformylglycinamidine synthase activity
EXE57_RS14020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXE57_RS14055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXE57_RS14065	COG5002	protein histidine kinase activity
EXE57_RS14075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXE57_RS14120	COG1252	NADH dehydrogenase
EXE57_RS14135	COG2197	response regulator
EXE57_RS14140	COG1615	UPF0182 protein
EXE57_RS14155	COG2201	protein-glutamate methylesterase activity
EXE57_RS14160	COG4585	Histidine kinase
EXE57_RS14165	COG1940	carbohydrate kinase activity
EXE57_RS14210	COG0582	viral genome integration into host DNA
EXE57_RS14230	COG2197	response regulator
EXE57_RS14235	COG0723	plastoquinol--plastocyanin reductase activity
EXE57_RS14235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXE57_RS14315	COG2197	response regulator
EXE57_RS14360	COG1295	ribonuclease BN
EXE57_RS14365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EXE57_RS14440	COG2409	Drug exporters of the RND superfamily
EXE57_RS14450	COG1131	(ABC) transporter
EXE57_RS14490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXE57_RS14490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXE57_RS14525	COG2197	response regulator
EXE57_RS14535	COG1278	Cold shock
EXE57_RS14550	COG0456	acetyltransferase
EXE57_RS14570	COG0798	PFAM Bile acid sodium symporter
EXE57_RS14575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXE57_RS14580	COG2072	flavoprotein involved in K transport
EXE57_RS14600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EXE57_RS14610	COG0306	phosphate transporter
EXE57_RS14620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EXE57_RS14625	COG0657	acetylesterase activity
EXE57_RS14630	COG1490	D-aminoacyl-tRNA deacylase activity
EXE57_RS14640	COG3246	L-lysine catabolic process to acetate
EXE57_RS14650	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EXE57_RS14670	COG0454	-acetyltransferase
EXE57_RS14670	COG0456	acetyltransferase
EXE57_RS14680	COG0745	RESPONSE REGULATOR receiver
EXE57_RS14695	COG0789	Transcriptional regulator
EXE57_RS14700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXE57_RS14705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXE57_RS14745	COG1742	UPF0060 membrane protein
EXE57_RS14815	COG0730	response to heat
EXE57_RS14825	COG0529	Catalyzes the synthesis of activated sulfate
EXE57_RS14830	COG0662	Cupin 2, conserved barrel domain protein
EXE57_RS14830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EXE57_RS14885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXE57_RS14900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXE57_RS14905	COG0588	phosphoglycerate mutase activity
EXE57_RS14930	COG1217	gtp-binding protein TYPA
EXE57_RS14935	COG3467	pyridoxamine 5'-phosphate
EXE57_RS14940	COG0328	RNA-DNA hybrid ribonuclease activity
EXE57_RS14945	COG1794	racemase activity, acting on amino acids and derivatives
EXE57_RS14965	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS14985	COG0745	RESPONSE REGULATOR receiver
EXE57_RS14990	COG5002	protein histidine kinase activity
EXE57_RS15000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXE57_RS15015	COG0588	phosphoglycerate mutase activity
EXE57_RS15030	COG1329	Transcriptional regulator
EXE57_RS15035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EXE57_RS15050	COG0215	cysteine-tRNA ligase activity
EXE57_RS15055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXE57_RS15065	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS15095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EXE57_RS15100	COG3619	membrane
EXE57_RS15115	COG0405	Gamma-glutamyltransferase
EXE57_RS15120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXE57_RS15125	COG0601	transmembrane transport
EXE57_RS15135	COG3384	dioxygenase
EXE57_RS15140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXE57_RS15155	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EXE57_RS15185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXE57_RS15190	COG2755	lipolytic protein G-D-S-L family
EXE57_RS15230	COG0459	protein refolding
EXE57_RS15250	COG0431	NADPH-dependent FMN reductase
EXE57_RS15265	COG1609	Transcriptional regulator
EXE57_RS15270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXE57_RS15275	COG0698	ribose 5-phosphate isomerase
EXE57_RS15295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXE57_RS15315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXE57_RS15320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXE57_RS15350	COG2188	Transcriptional regulator
EXE57_RS15385	COG0783	Belongs to the Dps family
EXE57_RS15395	COG1061	Type III restriction enzyme res subunit
EXE57_RS15400	COG2890	protein-(glutamine-N5) methyltransferase activity
EXE57_RS15415	COG0631	protein serine/threonine phosphatase activity
EXE57_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS15440	COG0483	inositol monophosphate 1-phosphatase activity
EXE57_RS15445	COG0318	PFAM AMP-dependent synthetase and ligase
EXE57_RS15450	COG1404	Belongs to the peptidase S8 family
EXE57_RS15460	COG1278	Cold shock
EXE57_RS15465	COG2814	Major facilitator Superfamily
EXE57_RS15485	COG2252	PERMEase
EXE57_RS15490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXE57_RS15505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXE57_RS15510	COG0049	tRNA binding
EXE57_RS15515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXE57_RS15520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXE57_RS15535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXE57_RS15540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXE57_RS15550	COG2271	Major facilitator Superfamily
EXE57_RS15555	COG0051	transcription antitermination factor activity, RNA binding
EXE57_RS15560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXE57_RS15565	COG0088	Forms part of the polypeptide exit tunnel
EXE57_RS15570	COG0089	rRNA binding
EXE57_RS15575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXE57_RS15580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXE57_RS15585	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXE57_RS15590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EXE57_RS15595	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXE57_RS15600	COG0255	Belongs to the universal ribosomal protein uL29 family
EXE57_RS15605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXE57_RS15610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXE57_RS15615	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXE57_RS15620	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXE57_RS15625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EXE57_RS15630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXE57_RS15635	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EXE57_RS15640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXE57_RS15645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EXE57_RS15650	COG1841	ribosomal large subunit assembly
EXE57_RS15655	COG0200	Binds to the 23S rRNA
EXE57_RS15665	COG0563	adenylate kinase activity
EXE57_RS15680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXE57_RS15685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EXE57_RS15690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXE57_RS15695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXE57_RS15700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXE57_RS15705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXE57_RS15710	COG0202	RNA polymerase activity
EXE57_RS15715	COG0203	ribosomal protein L17
EXE57_RS15720	COG1725	Transcriptional regulator
EXE57_RS15725	COG3152	Membrane
EXE57_RS15755	COG2813	Specifically methylates the guanine in position
EXE57_RS15770	COG0667	Aldo Keto reductase
EXE57_RS15785	COG1960	acyl-CoA dehydrogenase activity
EXE57_RS15790	COG0488	(ABC) transporter
EXE57_RS15805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXE57_RS15810	COG2755	lipolytic protein G-D-S-L family
EXE57_RS15810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXE57_RS15835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXE57_RS15840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXE57_RS15845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXE57_RS15855	COG1764	response to oxidative stress
EXE57_RS15860	COG1072	(Pantothenic acid kinase))
EXE57_RS15865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EXE57_RS15870	COG0736	holo-[acyl-carrier-protein] synthase activity
EXE57_RS15885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXE57_RS15900	COG0456	acetyltransferase
EXE57_RS15900	COG1214	PFAM Peptidase M22, glycoprotease
EXE57_RS15915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EXE57_RS15940	COG2318	DinB family
EXE57_RS15955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EXE57_RS15965	COG2372	response to copper ion
EXE57_RS15965	COG1276	copper resistance
EXE57_RS16015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXE57_RS16020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXE57_RS16030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXE57_RS16060	COG1253	flavin adenine dinucleotide binding
EXE57_RS16070	COG1331	Highly conserved protein containing a thioredoxin domain
EXE57_RS16080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EXE57_RS16085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXE57_RS16095	COG0114	fumarate hydratase activity
EXE57_RS16140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EXE57_RS16140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EXE57_RS16150	COG1609	Transcriptional regulator
EXE57_RS16155	COG1653	transport
EXE57_RS16160	COG1175	transmembrane transport
EXE57_RS16165	COG0395	ABC-type sugar transport system, permease component
EXE57_RS16170	COG3842	ATPase activity
EXE57_RS16220	COG1722	exodeoxyribonuclease VII activity
EXE57_RS16225	COG1570	exodeoxyribonuclease VII activity
EXE57_RS16245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXE57_RS16250	COG0009	L-threonylcarbamoyladenylate synthase
EXE57_RS16260	COG1322	Protein conserved in bacteria
EXE57_RS16270	COG0500	methyltransferase
EXE57_RS16275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXE57_RS16285	COG0463	Glycosyl transferase, family 2
EXE57_RS16315	COG0012	GTP binding
EXE57_RS16340	COG1070	Carbohydrate kinase
EXE57_RS16350	COG1129	ABC transporter
EXE57_RS16355	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXE57_RS16360	COG1879	ABC-type sugar transport system periplasmic component
EXE57_RS16380	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EXE57_RS16380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXE57_RS16395	COG5002	protein histidine kinase activity
EXE57_RS16395	COG2205	protein histidine kinase activity
EXE57_RS16395	COG0784	Response regulator, receiver
EXE57_RS16410	COG0494	nUDIX hydrolase
EXE57_RS16420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXE57_RS16430	COG1984	allophanate hydrolase subunit 2
EXE57_RS16435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXE57_RS16440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXE57_RS16465	COG2130	NADP-dependent
EXE57_RS16515	COG0247	lactate metabolic process
EXE57_RS16515	COG0277	FAD linked oxidase domain protein
EXE57_RS16520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXE57_RS16535	COG1414	Transcriptional regulator
EXE57_RS16540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXE57_RS16545	COG2318	DinB family
EXE57_RS16550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXE57_RS16560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXE57_RS16565	COG1611	Belongs to the LOG family
EXE57_RS16585	COG1024	Enoyl-CoA hydratase
EXE57_RS16600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXE57_RS16625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXE57_RS16630	COG1910	domain protein
EXE57_RS16665	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS16675	COG2902	Dehydrogenase
EXE57_RS16680	COG1131	(ABC) transporter
EXE57_RS16700	COG0477	Major facilitator Superfamily
EXE57_RS16710	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EXE57_RS16725	COG1793	dna ligase
EXE57_RS16735	COG3285	dna ligase
EXE57_RS16735	COG1793	dna ligase
EXE57_RS16745	COG0745	RESPONSE REGULATOR receiver
EXE57_RS16750	COG0642	Histidine kinase
EXE57_RS16755	COG0183	Belongs to the thiolase family
EXE57_RS16950	COG0154	amidase activity
EXE57_RS16955	COG1252	NADH dehydrogenase
EXE57_RS16965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXE57_RS16970	COG2814	Major facilitator Superfamily
EXE57_RS16975	COG2340	Cysteine-rich secretory protein family
EXE57_RS16980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EXE57_RS16995	COG2851	Citrate transporter
EXE57_RS17000	COG0583	DNA-binding transcription factor activity
EXE57_RS17005	COG2610	gluconate transmembrane transporter activity
EXE57_RS17010	COG3265	gluconokinase activity
EXE57_RS17020	COG2884	Cell division ATP-binding protein ftsE
EXE57_RS17035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXE57_RS17075	COG0022	dehydrogenase e1 component
EXE57_RS17100	COG3304	Inner membrane component domain
EXE57_RS17135	COG0537	adenosine 5'-monophosphoramidase activity
EXE57_RS17140	COG1028	Short-chain dehydrogenase reductase Sdr
EXE57_RS17155	COG1309	transcriptional regulator
EXE57_RS17165	COG1678	Uncharacterized ACR, COG1678
EXE57_RS17170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXE57_RS17195	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXE57_RS17215	COG1024	Enoyl-CoA hydratase
EXE57_RS17220	COG1335	isochorismatase
EXE57_RS17235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EXE57_RS17250	COG2409	Drug exporters of the RND superfamily
EXE57_RS17300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXE57_RS17305	COG1234	tRNA 3'-trailer cleavage
EXE57_RS17310	COG2197	response regulator
EXE57_RS17315	COG4585	Histidine kinase
EXE57_RS17320	COG1131	(ABC) transporter
EXE57_RS17330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXE57_RS17335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EXE57_RS17365	COG1122	ATPase activity
EXE57_RS17375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXE57_RS17390	COG1012	belongs to the aldehyde dehydrogenase family
EXE57_RS17400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXE57_RS17430	COG0644	oxidoreductase
EXE57_RS17435	COG2072	flavoprotein involved in K transport
EXE57_RS17465	COG4585	Histidine kinase
EXE57_RS17470	COG2197	response regulator
EXE57_RS17500	COG1741	Belongs to the pirin family
EXE57_RS17510	COG4988	ABC transporter
EXE57_RS17515	COG1294	oxidase, subunit
EXE57_RS17520	COG1271	oxidase subunit
EXE57_RS17535	COG0516	GMP reductase activity
EXE57_RS17535	COG0517	IMP dehydrogenase activity
EXE57_RS17550	COG4585	Histidine kinase
EXE57_RS17570	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EXE57_RS17590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EXE57_RS17620	COG2843	Capsule synthesis protein
EXE57_RS17625	COG0006	proline dipeptidase activity
EXE57_RS17630	COG2339	peptidase activity
EXE57_RS17635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXE57_RS17645	COG0629	single-stranded DNA binding
EXE57_RS17660	COG0183	Belongs to the thiolase family
EXE57_RS17665	COG3795	YCII-related domain
EXE57_RS17685	COG2346	COG2346, Truncated hemoglobins
EXE57_RS17690	COG0668	transmembrane transport
EXE57_RS17715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXE57_RS17730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXE57_RS17735	COG0657	acetylesterase activity
EXE57_RS17740	COG0584	glycerophosphoryl diester phosphodiesterase
EXE57_RS17745	COG4552	Acetyltransferase involved in intracellular survival and related
EXE57_RS17755	COG0698	ribose 5-phosphate isomerase
EXE57_RS17780	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXE57_RS17790	COG0740	serine-type endopeptidase activity
EXE57_RS17795	COG0740	serine-type endopeptidase activity
EXE57_RS17800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EXE57_RS17810	COG0525	valine-tRNA ligase activity
EXE57_RS17825	COG0285	dihydrofolate synthase activity
EXE57_RS17850	COG0105	UTP biosynthetic process
EXE57_RS17865	COG1077	Cell shape determining protein MreB Mrl
EXE57_RS17880	COG0768	penicillin binding
EXE57_RS17885	COG0772	Belongs to the SEDS family
EXE57_RS17890	COG0387	Pfam Sodium calcium exchanger
EXE57_RS17895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXE57_RS17895	COG2205	protein histidine kinase activity
EXE57_RS17925	COG1530	ribonuclease E activity
EXE57_RS17930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EXE57_RS17935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EXE57_RS17940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXE57_RS17945	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXE57_RS17960	COG0482	sulfurtransferase activity
EXE57_RS17985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXE57_RS18000	COG2755	lipolytic protein G-D-S-L family
EXE57_RS18015	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXE57_RS18020	COG0154	amidase activity
EXE57_RS18025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXE57_RS18030	COG1492	cobalamin metabolic process
EXE57_RS18045	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXE57_RS18050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXE57_RS18055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXE57_RS18060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EXE57_RS18065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EXE57_RS18070	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EXE57_RS18080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EXE57_RS18085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EXE57_RS18090	COG2133	pyrroloquinoline quinone binding
EXE57_RS18095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXE57_RS18105	COG5006	permease, DMT superfamily
EXE57_RS18125	COG3540	Alkaline phosphatase
EXE57_RS18135	COG0129	dihydroxy-acid dehydratase activity
EXE57_RS18175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EXE57_RS18185	COG1131	(ABC) transporter
EXE57_RS18205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXE57_RS18220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXE57_RS18225	COG2364	Membrane
EXE57_RS18245	COG0473	3-isopropylmalate dehydrogenase activity
EXE57_RS18255	COG4585	Histidine kinase
EXE57_RS18260	COG2197	response regulator
EXE57_RS18265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXE57_RS18285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXE57_RS18300	COG1122	ATPase activity
EXE57_RS18305	COG1268	BioY protein
EXE57_RS18320	COG4942	peptidase
EXE57_RS18340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXE57_RS18340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXE57_RS18360	COG2409	Drug exporters of the RND superfamily
EXE57_RS18395	COG1414	Transcriptional regulator
EXE57_RS18400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXE57_RS18405	COG0066	3-isopropylmalate dehydratase activity
EXE57_RS18410	COG0776	regulation of translation
EXE57_RS18415	COG1920	GTP binding
EXE57_RS18425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXE57_RS18445	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXE57_RS18475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EXE57_RS18480	COG1461	Dihydroxyacetone kinase
EXE57_RS18495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXE57_RS18505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXE57_RS18510	COG0571	ribonuclease III activity
EXE57_RS18515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EXE57_RS18530	COG2267	carboxylic ester hydrolase activity
EXE57_RS18535	COG0277	FAD linked oxidase domain protein
EXE57_RS18540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXE57_RS18545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXE57_RS18585	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EXE57_RS18610	COG0228	four-way junction DNA binding
EXE57_RS18615	COG1837	Belongs to the UPF0109 family
EXE57_RS18620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXE57_RS18625	COG4166	transmembrane transport
EXE57_RS18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXE57_RS18640	COG0444	Belongs to the ABC transporter superfamily
EXE57_RS18645	COG4608	Belongs to the ABC transporter superfamily
EXE57_RS18655	COG0336	Belongs to the RNA methyltransferase TrmD family
EXE57_RS18660	COG0335	large ribosomal subunit rRNA binding
EXE57_RS18665	COG0681	Belongs to the peptidase S26 family
EXE57_RS18670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXE57_RS18690	COG0792	nuclease activity
EXE57_RS18700	COG0758	DNA mediated transformation
EXE57_RS18705	COG4974	Belongs to the 'phage' integrase family
EXE57_RS18720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXE57_RS18730	COG0528	UMP kinase activity
EXE57_RS18735	COG0233	cytoplasmic translational termination
EXE57_RS18760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXE57_RS18785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXE57_RS18800	COG1834	amidinotransferase
EXE57_RS18820	COG3842	ATPase activity
EXE57_RS18825	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXE57_RS18830	COG1177	transmembrane transport
EXE57_RS18835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXE57_RS18845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXE57_RS18875	COG0750	zinc metalloprotease
EXE57_RS18880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXE57_RS18895	COG0442	prolyl-tRNA aminoacylation
EXE57_RS18920	COG0779	Required for maturation of 30S ribosomal subunits
EXE57_RS18940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXE57_RS18945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXE57_RS18950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EXE57_RS18955	COG0196	riboflavin kinase activity
EXE57_RS18965	COG0626	cystathionine gamma-synthase activity
EXE57_RS18980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXE57_RS18980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXE57_RS18980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXE57_RS18990	COG1349	DNA-binding transcription factor activity
EXE57_RS18995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EXE57_RS19000	COG1063	alcohol dehydrogenase
EXE57_RS19005	COG2213	PTS system mannitol-specific
EXE57_RS19005	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXE57_RS19015	COG4941	Belongs to the sigma-70 factor family
EXE57_RS19025	COG0243	molybdopterin cofactor binding
EXE57_RS19035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EXE57_RS19040	COG1185	polyribonucleotide nucleotidyltransferase activity
EXE57_RS19045	COG0612	Peptidase, M16
EXE57_RS19050	COG0500	methyltransferase
EXE57_RS19055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXE57_RS19080	COG3396	Phenylacetate-CoA oxygenase
EXE57_RS19085	COG3460	Phenylacetate-CoA oxygenase
EXE57_RS19090	COG3396	Phenylacetate-CoA oxygenase
EXE57_RS19095	COG2151	metal-sulfur cluster biosynthetic enzyme
EXE57_RS19100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EXE57_RS19120	COG0501	Belongs to the peptidase M48B family
EXE57_RS19130	COG0642	Histidine kinase
EXE57_RS19135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXE57_RS19160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXE57_RS19170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXE57_RS19185	COG1376	ErfK ybiS ycfS ynhG family protein
EXE57_RS19200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXE57_RS19205	COG0723	plastoquinol--plastocyanin reductase activity
EXE57_RS19210	COG2010	Cytochrome c
EXE57_RS19215	COG1845	cytochrome c oxidase, subunit III
EXE57_RS19230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXE57_RS19240	COG1215	transferase activity, transferring glycosyl groups
EXE57_RS19255	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EXE57_RS19255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXE57_RS19260	COG0560	Phosphoserine phosphatase
EXE57_RS19270	COG3475	LICD family
EXE57_RS19305	COG0791	NLP P60 protein
EXE57_RS19315	COG0501	Belongs to the peptidase M48B family
EXE57_RS19335	COG4585	Histidine kinase
EXE57_RS19365	COG1022	Amp-dependent synthetase and ligase
EXE57_RS19375	COG0003	Pfam Anion-transporting ATPase
EXE57_RS19385	COG1940	carbohydrate kinase activity
EXE57_RS19390	COG1940	carbohydrate kinase activity
EXE57_RS19420	COG2197	response regulator
EXE57_RS19450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXE57_RS19470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EXE57_RS19490	COG0438	transferase activity, transferring glycosyl groups
EXE57_RS19500	COG0741	lytic transglycosylase activity