locus-tag	class	description
GFH29_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFH29_RS00010	COG1846	Transcriptional regulator
GFH29_RS00015	COG1764	response to oxidative stress
GFH29_RS00020	COG0592	DNA-directed DNA polymerase activity
GFH29_RS00025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GFH29_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFH29_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
GFH29_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH29_RS00115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFH29_RS00120	COG0457	Tetratricopeptide repeat
GFH29_RS00120	COG0705	Rhomboid family
GFH29_RS00140	COG0515	serine threonine protein kinase
GFH29_RS00145	COG0515	serine threonine protein kinase
GFH29_RS00150	COG0768	penicillin binding
GFH29_RS00165	COG1716	ATPase activity
GFH29_RS00170	COG1716	ATPase activity
GFH29_RS00200	COG0386	Belongs to the glutathione peroxidase family
GFH29_RS00205	COG2409	Drug exporters of the RND superfamily
GFH29_RS00225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH29_RS00275	COG3590	peptidase
GFH29_RS00300	COG0514	ATP-dependent DNA helicase (RecQ)
GFH29_RS00305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS00310	COG0477	Major facilitator Superfamily
GFH29_RS00315	COG0386	Belongs to the glutathione peroxidase family
GFH29_RS00320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH29_RS00340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GFH29_RS00360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH29_RS00385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GFH29_RS00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH29_RS00410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH29_RS00425	COG0653	protein targeting
GFH29_RS00430	COG2235	arginine
GFH29_RS00435	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GFH29_RS00440	COG1691	(AIR) carboxylase
GFH29_RS00445	COG1605	Chorismate mutase
GFH29_RS00445	COG0077	Prephenate dehydratase
GFH29_RS00465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFH29_RS00470	COG0561	phosphatase activity
GFH29_RS00480	COG0561	phosphatase activity
GFH29_RS00505	COG0746	molybdenum cofactor guanylyltransferase activity
GFH29_RS00510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GFH29_RS00520	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFH29_RS00545	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS00700	COG4152	abc transporter atp-binding protein
GFH29_RS00725	COG2197	response regulator
GFH29_RS00750	COG2197	response regulator
GFH29_RS00755	COG4585	Histidine kinase
GFH29_RS00780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS00830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GFH29_RS00850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GFH29_RS00855	COG1074	ATP-dependent DNA helicase activity
GFH29_RS00860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH29_RS00870	COG0477	Major facilitator Superfamily
GFH29_RS00940	COG2814	Major facilitator Superfamily
GFH29_RS00950	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS00955	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS01005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS01010	COG1053	succinate dehydrogenase
GFH29_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS01075	COG1609	Transcriptional regulator
GFH29_RS01080	COG1024	Enoyl-CoA hydratase
GFH29_RS01085	COG0640	Transcriptional regulator
GFH29_RS01090	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFH29_RS01095	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFH29_RS01095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFH29_RS01100	COG2084	Dehydrogenase
GFH29_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS01120	COG1024	Enoyl-CoA hydratase
GFH29_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS01145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GFH29_RS01150	COG2124	cytochrome p450
GFH29_RS01175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH29_RS01205	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS01250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFH29_RS01260	COG0590	tRNA wobble adenosine to inosine editing
GFH29_RS01280	COG0494	nUDIX hydrolase
GFH29_RS01285	COG1742	UPF0060 membrane protein
GFH29_RS01300	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS01305	COG0542	response to heat
GFH29_RS01315	COG0436	Aminotransferase
GFH29_RS01320	COG1053	succinate dehydrogenase
GFH29_RS01325	COG3263	regulation of cellular component size
GFH29_RS01345	COG1674	ftsk spoiiie
GFH29_RS01380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFH29_RS01385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFH29_RS01425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH29_RS01435	COG0003	Pfam Anion-transporting ATPase
GFH29_RS01445	COG1414	Transcriptional regulator
GFH29_RS01470	COG1914	H( )-stimulated, divalent metal cation uptake system
GFH29_RS01475	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS01485	COG0577	efflux transmembrane transporter activity
GFH29_RS01490	COG1136	(ABC) transporter
GFH29_RS01490	COG0577	efflux transmembrane transporter activity
GFH29_RS01500	COG2197	response regulator
GFH29_RS01505	COG4585	Histidine kinase
GFH29_RS01515	COG0251	oxidation-reduction process
GFH29_RS01540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFH29_RS01545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH29_RS01550	COG0494	nUDIX hydrolase
GFH29_RS01565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GFH29_RS01575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFH29_RS01580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH29_RS01595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GFH29_RS01610	COG3275	phosphorelay sensor kinase activity
GFH29_RS01625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GFH29_RS01630	COG1116	anion transmembrane transporter activity
GFH29_RS01635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS01675	COG1111	helicase
GFH29_RS01675	COG1205	dead DEAH box helicase
GFH29_RS01680	COG1366	Belongs to the anti-sigma-factor antagonist family
GFH29_RS01685	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GFH29_RS01690	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH29_RS01695	COG1754	DNA topoisomerase type I activity
GFH29_RS01695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFH29_RS01700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFH29_RS01705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFH29_RS01730	COG0778	Nitroreductase
GFH29_RS01735	COG1733	regulation of RNA biosynthetic process
GFH29_RS01745	COG3619	membrane
GFH29_RS01760	COG0110	maltose O-acetyltransferase activity
GFH29_RS01765	COG1414	Transcriptional regulator
GFH29_RS01770	COG3971	2-oxopent-4-enoate hydratase activity
GFH29_RS01775	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GFH29_RS01780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH29_RS01795	COG3396	Phenylacetate-CoA oxygenase
GFH29_RS01800	COG3460	Phenylacetate-CoA oxygenase
GFH29_RS01805	COG3396	Phenylacetate-CoA oxygenase
GFH29_RS01810	COG2151	metal-sulfur cluster biosynthetic enzyme
GFH29_RS01815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GFH29_RS01825	COG0667	Aldo Keto reductase
GFH29_RS01840	COG0328	RNA-DNA hybrid ribonuclease activity
GFH29_RS01860	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS01870	COG1309	transcriptional regulator
GFH29_RS01895	COG4221	oxidoreductase activity
GFH29_RS01900	COG0183	Belongs to the thiolase family
GFH29_RS01905	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS01910	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS01915	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS01930	COG4166	transmembrane transport
GFH29_RS01940	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS01945	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS01955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS01960	COG1414	Transcriptional regulator
GFH29_RS01965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH29_RS01970	COG2267	carboxylic ester hydrolase activity
GFH29_RS01975	COG1053	succinate dehydrogenase
GFH29_RS01995	COG3976	FMN-binding domain protein
GFH29_RS01995	COG1053	succinate dehydrogenase
GFH29_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS02025	COG2030	dehydratase
GFH29_RS02040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS02045	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS02050	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS02055	COG0601	transmembrane transport
GFH29_RS02060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS02065	COG0444	Belongs to the ABC transporter superfamily
GFH29_RS02070	COG4608	Belongs to the ABC transporter superfamily
GFH29_RS02105	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS02110	COG0183	Belongs to the thiolase family
GFH29_RS02115	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS02120	COG1309	transcriptional regulator
GFH29_RS02135	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02140	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02145	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02150	COG1024	Enoyl-CoA hydratase
GFH29_RS02155	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02165	COG0183	Belongs to the thiolase family
GFH29_RS02195	COG1024	Enoyl-CoA hydratase
GFH29_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS02225	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02230	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS02245	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH29_RS02290	COG3842	ATPase activity
GFH29_RS02310	COG2027	D-alanyl-D-alanine carboxypeptidase
GFH29_RS02320	COG0037	tRNA processing
GFH29_RS02345	COG0302	gtp cyclohydrolase
GFH29_RS02350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH29_RS02355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFH29_RS02380	COG0517	IMP dehydrogenase activity
GFH29_RS02380	COG1125	glycine betaine transport
GFH29_RS02390	COG1174	glycine betaine transport
GFH29_RS02400	COG1216	Glycosyl transferase, family 2
GFH29_RS02415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GFH29_RS02420	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GFH29_RS02425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GFH29_RS02435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GFH29_RS02460	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GFH29_RS02465	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GFH29_RS02470	COG2226	methyltransferase
GFH29_RS02485	COG0248	Ppx GppA phosphatase
GFH29_RS02490	COG1082	Xylose isomerase domain protein TIM barrel
GFH29_RS02505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GFH29_RS02515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFH29_RS02520	COG0123	including yeast histone deacetylase and acetoin utilization protein
GFH29_RS02550	COG1595	DNA-templated transcription, initiation
GFH29_RS02560	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS02570	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFH29_RS02575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GFH29_RS02585	COG1648	precorrin-2 dehydrogenase activity
GFH29_RS02585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH29_RS02590	COG0113	porphobilinogen synthase activity
GFH29_RS02595	COG0730	response to heat
GFH29_RS02605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GFH29_RS02610	COG0406	alpha-ribazole phosphatase activity
GFH29_RS02620	COG0785	Cytochrome C biogenesis protein
GFH29_RS02625	COG1333	cytochrome c biogenesis protein
GFH29_RS02630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GFH29_RS02675	COG4948	Mandelate Racemase Muconate Lactonizing
GFH29_RS02680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFH29_RS02700	COG1169	isochorismate synthase
GFH29_RS02710	COG2226	methyltransferase
GFH29_RS02720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH29_RS02725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH29_RS02730	COG0649	NAD binding
GFH29_RS02745	COG1034	ATP synthesis coupled electron transport
GFH29_RS02750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GFH29_RS02755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GFH29_RS02760	COG0839	Belongs to the complex I subunit 6 family
GFH29_RS02765	COG0713	ATP synthesis coupled electron transport
GFH29_RS02770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH29_RS02780	COG1007	ATP synthesis coupled electron transport
GFH29_RS02785	COG0142	geranyltranstransferase activity
GFH29_RS02800	COG1013	pyruvate-flavodoxin oxidoreductase activity
GFH29_RS02805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GFH29_RS02805	COG0674	pyruvate-flavodoxin oxidoreductase activity
GFH29_RS02820	COG4208	sulfate ABC transporter
GFH29_RS02825	COG3842	ATPase activity
GFH29_RS02830	COG1666	GTP binding
GFH29_RS02840	COG0477	Major facilitator Superfamily
GFH29_RS02845	COG1309	transcriptional regulator
GFH29_RS02850	COG1335	isochorismatase
GFH29_RS02900	COG0519	Catalyzes the synthesis of GMP from XMP
GFH29_RS02905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH29_RS02910	COG1380	Effector of murein hydrolase LrgA
GFH29_RS02915	COG1346	cytolysis
GFH29_RS02945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFH29_RS02950	COG2030	dehydratase
GFH29_RS02960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFH29_RS02970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH29_RS02990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFH29_RS02995	COG0081	regulation of translation
GFH29_RS03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH29_RS03005	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFH29_RS03010	COG0222	ribosome binding
GFH29_RS03020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH29_RS03025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GFH29_RS03070	COG0085	RNA polymerase activity
GFH29_RS03075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFH29_RS03080	COG0644	oxidoreductase
GFH29_RS03095	COG0277	FAD linked oxidase domain protein
GFH29_RS03095	COG0247	lactate metabolic process
GFH29_RS03120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GFH29_RS03130	COG4221	oxidoreductase activity
GFH29_RS03135	COG0259	pyridoxamine-phosphate oxidase activity
GFH29_RS03155	COG0477	Major facilitator Superfamily
GFH29_RS03165	COG0366	Alpha amylase catalytic
GFH29_RS03180	COG1321	iron dependent repressor
GFH29_RS03200	COG3268	Saccharopine dehydrogenase
GFH29_RS03230	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS03245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GFH29_RS03250	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GFH29_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS03260	COG0667	Aldo Keto reductase
GFH29_RS03265	COG3384	dioxygenase
GFH29_RS03270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFH29_RS03290	COG0069	glutamate synthase activity
GFH29_RS03300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GFH29_RS03310	COG2197	response regulator
GFH29_RS03345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GFH29_RS03360	COG0459	protein refolding
GFH29_RS03380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFH29_RS03400	COG0823	Involved in the tonB-independent uptake of proteins
GFH29_RS03400	COG1506	peptidase
GFH29_RS03435	COG0667	Aldo Keto reductase
GFH29_RS03445	COG0577	efflux transmembrane transporter activity
GFH29_RS03445	COG1136	(ABC) transporter
GFH29_RS03450	COG1136	(ABC) transporter
GFH29_RS03450	COG0577	efflux transmembrane transporter activity
GFH29_RS03455	COG2188	Transcriptional regulator
GFH29_RS03495	COG3631	Ketosteroid isomerase-related protein
GFH29_RS03510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH29_RS03520	COG1061	Type III restriction enzyme res subunit
GFH29_RS03550	COG1278	Cold shock
GFH29_RS03555	COG2814	Major facilitator Superfamily
GFH29_RS03570	COG2252	PERMEase
GFH29_RS03580	COG2814	Major facilitator Superfamily
GFH29_RS03585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFH29_RS03590	COG0049	tRNA binding
GFH29_RS03595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFH29_RS03600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFH29_RS03605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFH29_RS03650	COG0051	transcription antitermination factor activity, RNA binding
GFH29_RS03655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFH29_RS03660	COG0088	Forms part of the polypeptide exit tunnel
GFH29_RS03665	COG0089	rRNA binding
GFH29_RS03670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFH29_RS03675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFH29_RS03680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFH29_RS03690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFH29_RS03695	COG0255	Belongs to the universal ribosomal protein uL29 family
GFH29_RS03700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFH29_RS03705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFH29_RS03710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFH29_RS03715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFH29_RS03720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFH29_RS03725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFH29_RS03730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFH29_RS03735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFH29_RS03740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFH29_RS03745	COG1841	ribosomal large subunit assembly
GFH29_RS03750	COG0200	Binds to the 23S rRNA
GFH29_RS03760	COG0563	adenylate kinase activity
GFH29_RS03770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS03775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFH29_RS03780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFH29_RS03785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFH29_RS03790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFH29_RS03795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFH29_RS03800	COG0202	RNA polymerase activity
GFH29_RS03805	COG0203	ribosomal protein L17
GFH29_RS03815	COG1725	Transcriptional regulator
GFH29_RS03825	COG0101	tRNA pseudouridine synthase activity
GFH29_RS03830	COG2813	Specifically methylates the guanine in position
GFH29_RS03870	COG0657	acetylesterase activity
GFH29_RS03875	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS03880	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS03925	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS03930	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS03935	COG1643	Atp-dependent helicase
GFH29_RS03980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GFH29_RS03985	COG0583	DNA-binding transcription factor activity
GFH29_RS03995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS04000	COG0431	NADPH-dependent FMN reductase
GFH29_RS04010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GFH29_RS04015	COG3253	May function as heme-dependent peroxidase
GFH29_RS04025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH29_RS04035	COG4552	Acetyltransferase involved in intracellular survival and related
GFH29_RS04050	COG1793	dna ligase
GFH29_RS04060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFH29_RS04065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFH29_RS04075	COG0193	aminoacyl-tRNA hydrolase activity
GFH29_RS04080	COG1218	3'(2'),5'-bisphosphate nucleotidase
GFH29_RS04095	COG0642	Histidine kinase
GFH29_RS04100	COG2197	response regulator
GFH29_RS04110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH29_RS04125	COG1216	Glycosyl transferase, family 2
GFH29_RS04125	COG0438	transferase activity, transferring glycosyl groups
GFH29_RS04195	COG0673	inositol 2-dehydrogenase activity
GFH29_RS04200	COG1088	dTDP-glucose 4,6-dehydratase activity
GFH29_RS04215	COG1215	transferase activity, transferring glycosyl groups
GFH29_RS04220	COG1215	transferase activity, transferring glycosyl groups
GFH29_RS04265	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH29_RS04295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH29_RS04340	COG0463	Glycosyl transferase, family 2
GFH29_RS04370	COG0142	geranyltranstransferase activity
GFH29_RS04390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GFH29_RS04400	COG0385	Bile acid
GFH29_RS04405	COG2072	flavoprotein involved in K transport
GFH29_RS04415	COG3285	dna ligase
GFH29_RS04415	COG1793	dna ligase
GFH29_RS04425	COG0745	RESPONSE REGULATOR receiver
GFH29_RS04435	COG0791	NLP P60 protein
GFH29_RS04590	COG0667	Aldo Keto reductase
GFH29_RS04595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS04605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS04620	COG2884	Cell division ATP-binding protein ftsE
GFH29_RS04625	COG2177	Part of the ABC transporter FtsEX involved in
GFH29_RS04635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFH29_RS04645	COG1253	flavin adenine dinucleotide binding
GFH29_RS04660	COG3842	ATPase activity
GFH29_RS04705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFH29_RS04770	COG1470	cell adhesion involved in biofilm formation
GFH29_RS04775	COG1309	transcriptional regulator
GFH29_RS04780	COG1678	Uncharacterized ACR, COG1678
GFH29_RS04800	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GFH29_RS04815	COG0300	oxidoreductase activity
GFH29_RS04825	COG1024	Enoyl-CoA hydratase
GFH29_RS04830	COG1335	isochorismatase
GFH29_RS04840	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GFH29_RS04850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFH29_RS04895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFH29_RS04900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFH29_RS04930	COG1122	ATPase activity
GFH29_RS04940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFH29_RS04955	COG0747	negative chemotaxis
GFH29_RS04970	COG1053	succinate dehydrogenase
GFH29_RS04985	COG0431	NADPH-dependent FMN reductase
GFH29_RS04985	COG1053	succinate dehydrogenase
GFH29_RS04985	COG3976	FMN-binding domain protein
GFH29_RS04995	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GFH29_RS05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS05020	COG0300	oxidoreductase activity
GFH29_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS05035	COG0583	DNA-binding transcription factor activity
GFH29_RS05050	COG4941	Belongs to the sigma-70 factor family
GFH29_RS05090	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS05095	COG1414	Transcriptional regulator
GFH29_RS05110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS05115	COG0444	Belongs to the ABC transporter superfamily
GFH29_RS05135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS05145	COG0444	Belongs to the ABC transporter superfamily
GFH29_RS05150	COG4608	Belongs to the ABC transporter superfamily
GFH29_RS05165	COG2186	Transcriptional regulator
GFH29_RS05170	COG1414	Transcriptional regulator
GFH29_RS05180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH29_RS05195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS05200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH29_RS05205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS05210	COG1335	isochorismatase
GFH29_RS05230	COG1802	Transcriptional regulator
GFH29_RS05240	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS05250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GFH29_RS05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GFH29_RS05305	COG3764	Sortase (surface protein transpeptidase)
GFH29_RS05325	COG0411	ABC transporter
GFH29_RS05365	COG2188	Transcriptional regulator
GFH29_RS05380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS05395	COG2030	dehydratase
GFH29_RS05405	COG0183	Belongs to the thiolase family
GFH29_RS05415	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS05430	COG4175	Glycine betaine
GFH29_RS05430	COG0517	IMP dehydrogenase activity
GFH29_RS05435	COG4176	ABC-type proline glycine betaine transport system permease component
GFH29_RS05440	COG2113	Glycine betaine
GFH29_RS05445	COG2233	PERMEase
GFH29_RS05475	COG5002	protein histidine kinase activity
GFH29_RS05495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GFH29_RS05510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH29_RS05565	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GFH29_RS05575	COG0758	DNA mediated transformation
GFH29_RS05585	COG2226	methyltransferase
GFH29_RS05605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFH29_RS05615	COG1335	isochorismatase
GFH29_RS05670	COG3467	pyridoxamine 5'-phosphate
GFH29_RS05685	COG0730	response to heat
GFH29_RS05690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH29_RS05690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH29_RS05700	COG1937	Protein conserved in bacteria
GFH29_RS05720	COG0583	DNA-binding transcription factor activity
GFH29_RS05735	COG3284	Transcriptional regulator
GFH29_RS05740	COG3350	monooxygenase activity
GFH29_RS05770	COG1063	alcohol dehydrogenase
GFH29_RS05775	COG0459	protein refolding
GFH29_RS05785	COG1321	iron dependent repressor
GFH29_RS05795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFH29_RS05800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GFH29_RS05810	COG3123	guanosine phosphorylase activity
GFH29_RS05820	COG1921	L-seryl-tRNASec selenium transferase activity
GFH29_RS05835	COG0243	molybdopterin cofactor binding
GFH29_RS05835	COG3383	formate dehydrogenase (NAD+) activity
GFH29_RS05840	COG0243	molybdopterin cofactor binding
GFH29_RS05840	COG3383	formate dehydrogenase (NAD+) activity
GFH29_RS05845	COG0437	4 iron, 4 sulfur cluster binding
GFH29_RS05875	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
GFH29_RS05880	COG1733	regulation of RNA biosynthetic process
GFH29_RS05890	COG4608	Belongs to the ABC transporter superfamily
GFH29_RS05900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS05935	COG0006	proline dipeptidase activity
GFH29_RS05950	COG0481	GTPase activity
GFH29_RS05955	COG0629	single-stranded DNA binding
GFH29_RS05970	COG0183	Belongs to the thiolase family
GFH29_RS05975	COG0824	Thioesterase
GFH29_RS05990	COG0668	transmembrane transport
GFH29_RS06015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH29_RS06030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH29_RS06055	COG0698	ribose 5-phosphate isomerase
GFH29_RS06085	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFH29_RS06090	COG0740	serine-type endopeptidase activity
GFH29_RS06095	COG0740	serine-type endopeptidase activity
GFH29_RS06100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFH29_RS06105	COG0525	valine-tRNA ligase activity
GFH29_RS06125	COG0285	dihydrofolate synthase activity
GFH29_RS06135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFH29_RS06145	COG0105	UTP biosynthetic process
GFH29_RS06150	COG1077	Cell shape determining protein MreB Mrl
GFH29_RS06165	COG0768	penicillin binding
GFH29_RS06170	COG0772	Belongs to the SEDS family
GFH29_RS06175	COG0387	Pfam Sodium calcium exchanger
GFH29_RS06190	COG2807	transmembrane transport
GFH29_RS06200	COG1530	ribonuclease E activity
GFH29_RS06205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFH29_RS06210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFH29_RS06215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFH29_RS06220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFH29_RS06235	COG0482	sulfurtransferase activity
GFH29_RS06245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH29_RS06270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFH29_RS06280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH29_RS06285	COG0154	amidase activity
GFH29_RS06290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFH29_RS06330	COG3845	ABC transporter
GFH29_RS06340	COG2133	pyrroloquinoline quinone binding
GFH29_RS06345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GFH29_RS06350	COG5006	permease, DMT superfamily
GFH29_RS06360	COG0129	dihydroxy-acid dehydratase activity
GFH29_RS06370	COG1289	transmembrane transporter activity
GFH29_RS06380	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFH29_RS06400	COG0440	acetolactate synthase activity
GFH29_RS06405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GFH29_RS06415	COG1131	(ABC) transporter
GFH29_RS06420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GFH29_RS06470	COG0473	3-isopropylmalate dehydrogenase activity
GFH29_RS06475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH29_RS06480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS06490	COG1120	ATPase activity
GFH29_RS06505	COG1309	transcriptional regulator
GFH29_RS06510	COG0431	NADPH-dependent FMN reductase
GFH29_RS06515	COG0154	amidase activity
GFH29_RS06530	COG1122	ATPase activity
GFH29_RS06535	COG1268	BioY protein
GFH29_RS06550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH29_RS06565	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH29_RS06570	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GFH29_RS06570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFH29_RS06595	COG1316	TRANSCRIPTIONal
GFH29_RS06605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFH29_RS06610	COG1414	Transcriptional regulator
GFH29_RS06615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GFH29_RS06620	COG0066	3-isopropylmalate dehydratase activity
GFH29_RS06630	COG1920	GTP binding
GFH29_RS06640	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFH29_RS06650	COG0596	Alpha beta hydrolase
GFH29_RS06655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFH29_RS06660	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFH29_RS06665	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFH29_RS06685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFH29_RS06695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFH29_RS06700	COG0742	ribosomal rna small subunit methyltransferase
GFH29_RS06705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFH29_RS06715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFH29_RS06720	COG0571	ribonuclease III activity
GFH29_RS06725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH29_RS06755	COG0601	transmembrane transport
GFH29_RS06760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS06790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GFH29_RS06800	COG1966	Carbon starvation protein
GFH29_RS06830	COG0228	four-way junction DNA binding
GFH29_RS06835	COG1837	Belongs to the UPF0109 family
GFH29_RS06840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFH29_RS06845	COG0336	Belongs to the RNA methyltransferase TrmD family
GFH29_RS06850	COG0335	large ribosomal subunit rRNA binding
GFH29_RS06855	COG0681	Belongs to the peptidase S26 family
GFH29_RS06860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFH29_RS06870	COG0792	nuclease activity
GFH29_RS06900	COG0052	Belongs to the universal ribosomal protein uS2 family
GFH29_RS06905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFH29_RS06910	COG0528	UMP kinase activity
GFH29_RS06915	COG0233	cytoplasmic translational termination
GFH29_RS06935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFH29_RS06950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFH29_RS06950	COG0425	Belongs to the sulfur carrier protein TusA family
GFH29_RS06965	COG0514	ATP-dependent DNA helicase (RecQ)
GFH29_RS06980	COG4974	Belongs to the 'phage' integrase family
GFH29_RS07035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GFH29_RS07040	COG0750	zinc metalloprotease
GFH29_RS07045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GFH29_RS07055	COG0442	prolyl-tRNA aminoacylation
GFH29_RS07080	COG0779	Required for maturation of 30S ribosomal subunits
GFH29_RS07095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFH29_RS07100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFH29_RS07105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFH29_RS07110	COG0196	riboflavin kinase activity
GFH29_RS07120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH29_RS07125	COG2197	response regulator
GFH29_RS07130	COG4585	Histidine kinase
GFH29_RS07135	COG2409	Drug exporters of the RND superfamily
GFH29_RS07140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFH29_RS07145	COG1185	polyribonucleotide nucleotidyltransferase activity
GFH29_RS07150	COG0612	Peptidase, M16
GFH29_RS07170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFH29_RS07195	COG0667	Aldo Keto reductase
GFH29_RS07220	COG0501	Belongs to the peptidase M48B family
GFH29_RS07230	COG2824	Alkylphosphonate utilization operon protein PhnA
GFH29_RS07235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GFH29_RS07265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GFH29_RS07280	COG1104	cysteine desulfurase activity
GFH29_RS07285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GFH29_RS07290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH29_RS07300	COG1376	ErfK ybiS ycfS ynhG family protein
GFH29_RS07305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS07310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GFH29_RS07315	COG0723	plastoquinol--plastocyanin reductase activity
GFH29_RS07320	COG2010	Cytochrome c
GFH29_RS07325	COG1845	cytochrome c oxidase, subunit III
GFH29_RS07335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GFH29_RS07360	COG0791	NLP P60 protein
GFH29_RS07370	COG0501	Belongs to the peptidase M48B family
GFH29_RS07375	COG1022	Amp-dependent synthetase and ligase
GFH29_RS07385	COG0003	Pfam Anion-transporting ATPase
GFH29_RS07395	COG1940	carbohydrate kinase activity
GFH29_RS07400	COG1940	carbohydrate kinase activity
GFH29_RS07430	COG2197	response regulator
GFH29_RS07450	COG2367	Beta-lactamase
GFH29_RS07470	COG1595	DNA-templated transcription, initiation
GFH29_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS07485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFH29_RS07500	COG0205	6-phosphofructokinase activity
GFH29_RS07510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH29_RS07520	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GFH29_RS07530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFH29_RS07535	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFH29_RS07545	COG2815	serine threonine protein kinase
GFH29_RS07545	COG0515	serine threonine protein kinase
GFH29_RS07555	COG0142	geranyltranstransferase activity
GFH29_RS07590	COG2226	methyltransferase
GFH29_RS07610	COG0714	Associated with various cellular activities
GFH29_RS07615	COG2001	Belongs to the MraZ family
GFH29_RS07625	COG0275	rRNA processing
GFH29_RS07635	COG0768	penicillin binding
GFH29_RS07640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFH29_RS07645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH29_RS07650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFH29_RS07660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFH29_RS07665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFH29_RS07670	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GFH29_RS07680	COG1496	oxidoreductase activity
GFH29_RS07685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFH29_RS07690	COG1799	cell septum assembly
GFH29_RS07705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GFH29_RS07740	COG0587	DNA-directed DNA polymerase activity
GFH29_RS07750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFH29_RS07755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GFH29_RS07760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GFH29_RS07765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH29_RS07770	COG0131	Imidazoleglycerol-phosphate dehydratase
GFH29_RS07775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GFH29_RS07780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GFH29_RS07785	COG0107	imidazoleglycerol-phosphate synthase activity
GFH29_RS07805	COG0277	FAD linked oxidase domain protein
GFH29_RS07815	COG1132	(ABC) transporter
GFH29_RS07820	COG1132	(ABC) transporter
GFH29_RS07825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GFH29_RS07850	COG0134	indole-3-glycerol-phosphate synthase activity
GFH29_RS07860	COG0159	tryptophan synthase activity
GFH29_RS07865	COG1999	signal sequence binding
GFH29_RS07870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFH29_RS07875	COG0070	glutamate synthase
GFH29_RS07875	COG0067	glutamate synthase
GFH29_RS07875	COG0069	glutamate synthase activity
GFH29_RS07920	COG0559	Belongs to the binding-protein-dependent transport system permease family
GFH29_RS07925	COG1811	Na channel or pump
GFH29_RS07950	COG4981	capsule polysaccharide biosynthetic process
GFH29_RS07960	COG0463	Glycosyl transferase, family 2
GFH29_RS07965	COG0438	transferase activity, transferring glycosyl groups
GFH29_RS07985	COG2226	methyltransferase
GFH29_RS07990	COG0539	negative regulation of cytoplasmic translation
GFH29_RS08020	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFH29_RS08030	COG0237	dephospho-CoA kinase activity
GFH29_RS08045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GFH29_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS08060	COG1984	allophanate hydrolase subunit 2
GFH29_RS08065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFH29_RS08085	COG0589	response to stress
GFH29_RS08095	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GFH29_RS08100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GFH29_RS08100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GFH29_RS08105	COG3639	organic phosphonate transmembrane transporter activity
GFH29_RS08130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFH29_RS08130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFH29_RS08155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFH29_RS08170	COG0187	DNA topoisomerase II activity
GFH29_RS08180	COG0477	Major facilitator Superfamily
GFH29_RS08190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFH29_RS08250	COG3850	Histidine kinase
GFH29_RS08310	COG0515	serine threonine protein kinase
GFH29_RS08340	COG1435	thymidine kinase activity
GFH29_RS08355	COG2860	membrane
GFH29_RS08385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GFH29_RS08410	COG0756	dUTP diphosphatase activity
GFH29_RS08435	COG0569	domain protein
GFH29_RS08440	COG0531	amino acid
GFH29_RS08445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH29_RS08465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS08475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GFH29_RS08485	COG1595	DNA-templated transcription, initiation
GFH29_RS08525	COG0515	serine threonine protein kinase
GFH29_RS08535	COG1131	(ABC) transporter
GFH29_RS08550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS08580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GFH29_RS08590	COG0531	amino acid
GFH29_RS08600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFH29_RS08605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFH29_RS08640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GFH29_RS08645	COG0540	Belongs to the ATCase OTCase family
GFH29_RS08650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFH29_RS08655	COG0505	Belongs to the CarA family
GFH29_RS08660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFH29_RS08665	COG0167	dihydroorotate dehydrogenase activity
GFH29_RS08675	COG0167	dihydroorotate dehydrogenase activity
GFH29_RS08680	COG0284	orotidine-5'-phosphate decarboxylase activity
GFH29_RS08695	COG0194	GDP metabolic process
GFH29_RS08700	COG1758	RNA polymerase activity
GFH29_RS08710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFH29_RS08720	COG0242	peptide deformylase activity
GFH29_RS08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFH29_RS08740	COG1116	anion transmembrane transporter activity
GFH29_RS08770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFH29_RS08795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GFH29_RS08800	COG0745	RESPONSE REGULATOR receiver
GFH29_RS08815	COG5002	protein histidine kinase activity
GFH29_RS08820	COG0140	phosphoribosyl-ATP diphosphatase activity
GFH29_RS08825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GFH29_RS08835	COG2017	converts alpha-aldose to the beta-anomer
GFH29_RS08860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFH29_RS08865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFH29_RS08870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFH29_RS08885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFH29_RS08890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFH29_RS08890	COG0072	phenylalanine-tRNA ligase activity
GFH29_RS08905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH29_RS08915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GFH29_RS08925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GFH29_RS08930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GFH29_RS08935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH29_RS08940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFH29_RS08945	COG1438	arginine binding
GFH29_RS08950	COG0137	argininosuccinate synthase activity
GFH29_RS08960	COG0165	Argininosuccinate lyase
GFH29_RS08965	COG2094	Belongs to the DNA glycosylase MPG family
GFH29_RS08995	COG0647	UMP catabolic process
GFH29_RS09010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFH29_RS09015	COG0497	DNA recombination
GFH29_RS09030	COG0504	CTP synthase activity
GFH29_RS09035	COG0494	nUDIX hydrolase
GFH29_RS09040	COG0686	Belongs to the AlaDH PNT family
GFH29_RS09075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFH29_RS09100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFH29_RS09110	COG1160	GTP binding
GFH29_RS09115	COG2318	DinB family
GFH29_RS09125	COG0789	Transcriptional regulator
GFH29_RS09135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFH29_RS09140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS09160	COG0300	oxidoreductase activity
GFH29_RS09215	COG2226	methyltransferase
GFH29_RS09240	COG2226	methyltransferase
GFH29_RS09265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH29_RS09270	COG0765	amino acid transport
GFH29_RS09340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GFH29_RS09345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GFH29_RS09350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GFH29_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS09375	COG1169	isochorismate synthase
GFH29_RS09380	COG1021	2,3-dihydroxybenzoate-AMP ligase
GFH29_RS09385	COG1535	isochorismatase
GFH29_RS09385	COG3433	isochorismatase activity
GFH29_RS09390	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GFH29_RS09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFH29_RS09415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFH29_RS09430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS09435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS09440	COG1120	ATPase activity
GFH29_RS09455	COG1120	ATPase activity
GFH29_RS09460	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS09465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS09480	COG1132	(ABC) transporter
GFH29_RS09485	COG1132	(ABC) transporter
GFH29_RS09535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH29_RS09600	COG0509	glycine decarboxylation via glycine cleavage system
GFH29_RS09605	COG1716	ATPase activity
GFH29_RS09625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH29_RS09625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH29_RS09655	COG0419	ATPase involved in DNA repair
GFH29_RS09660	COG0420	3'-5' exonuclease activity
GFH29_RS09665	COG0577	efflux transmembrane transporter activity
GFH29_RS09670	COG1136	(ABC) transporter
GFH29_RS09685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GFH29_RS09700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH29_RS09700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GFH29_RS09725	COG2130	NADP-dependent
GFH29_RS09755	COG1357	PFAM Pentapeptide repeats (8 copies)
GFH29_RS09780	COG1619	proteins homologs of microcin C7 resistance protein MccF
GFH29_RS09810	COG0596	Alpha beta hydrolase
GFH29_RS09815	COG2226	methyltransferase
GFH29_RS09840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFH29_RS09865	COG1216	Glycosyl transferase, family 2
GFH29_RS09870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GFH29_RS09875	COG1607	acyl-coa hydrolase
GFH29_RS09880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH29_RS09885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFH29_RS09890	COG0604	alcohol dehydrogenase
GFH29_RS09900	COG1522	sequence-specific DNA binding
GFH29_RS09905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFH29_RS09935	COG0805	protein transport
GFH29_RS09940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH29_RS09955	COG1047	Peptidyl-prolyl cis-trans
GFH29_RS09960	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH29_RS09970	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH29_RS09975	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GFH29_RS09985	COG4122	O-methyltransferase activity
GFH29_RS09990	COG0076	glutamate decarboxylase activity
GFH29_RS09995	COG1222	aaa ATPase
GFH29_RS10025	COG0215	cysteine-tRNA ligase activity
GFH29_RS10045	COG0598	Magnesium transport protein CorA
GFH29_RS10050	COG1968	undecaprenyl-diphosphatase activity
GFH29_RS10055	COG0667	Aldo Keto reductase
GFH29_RS10065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH29_RS10100	COG0693	protein deglycase activity
GFH29_RS10110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GFH29_RS10120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFH29_RS10130	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10135	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10160	COG0242	peptide deformylase activity
GFH29_RS10175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GFH29_RS10175	COG1648	precorrin-2 dehydrogenase activity
GFH29_RS10180	COG1881	PFAM PEBP family protein
GFH29_RS10190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS10235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GFH29_RS10265	COG0730	response to heat
GFH29_RS10280	COG1119	ATPase activity
GFH29_RS10290	COG3830	Belongs to the UPF0237 family
GFH29_RS10290	COG0560	Phosphoserine phosphatase
GFH29_RS10310	COG3360	Dodecin
GFH29_RS10325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GFH29_RS10335	COG1132	(ABC) transporter
GFH29_RS10345	COG0488	(ABC) transporter
GFH29_RS10350	COG0745	RESPONSE REGULATOR receiver
GFH29_RS10370	COG2151	metal-sulfur cluster biosynthetic enzyme
GFH29_RS10375	COG0822	iron-sulfur transferase activity
GFH29_RS10380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFH29_RS10385	COG0396	ATPase activity
GFH29_RS10390	COG2146	nitrite reductase [NAD(P)H] activity
GFH29_RS10420	COG1131	(ABC) transporter
GFH29_RS10440	COG0109	protoheme IX farnesyltransferase activity
GFH29_RS10450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GFH29_RS10455	COG0166	Belongs to the GPI family
GFH29_RS10470	COG0363	glucosamine-6-phosphate deaminase activity
GFH29_RS10485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFH29_RS10490	COG0149	triose-phosphate isomerase activity
GFH29_RS10495	COG0126	phosphoglycerate kinase activity
GFH29_RS10500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GFH29_RS10505	COG1481	regulation of sporulation
GFH29_RS10515	COG1660	Displays ATPase and GTPase activities
GFH29_RS10520	COG0322	excinuclease ABC activity
GFH29_RS10530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFH29_RS10570	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10575	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10580	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS10585	COG2070	2-Nitropropane dioxygenase
GFH29_RS10610	COG0667	Aldo Keto reductase
GFH29_RS10615	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS10620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS10635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFH29_RS10645	COG2124	cytochrome p450
GFH29_RS10650	COG2124	cytochrome p450
GFH29_RS10655	COG0183	Belongs to the thiolase family
GFH29_RS10665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH29_RS10670	COG0346	lactoylglutathione lyase activity
GFH29_RS10675	COG2267	carboxylic ester hydrolase activity
GFH29_RS10680	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10690	COG1053	succinate dehydrogenase
GFH29_RS10695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS10700	COG0657	acetylesterase activity
GFH29_RS10705	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS10720	COG2226	methyltransferase
GFH29_RS10730	COG1309	transcriptional regulator
GFH29_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS10755	COG0492	ferredoxin-NADP+ reductase activity
GFH29_RS10780	COG0556	nucleotide-excision repair
GFH29_RS10800	COG1024	Enoyl-CoA hydratase
GFH29_RS10815	COG2318	DinB family
GFH29_RS10905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GFH29_RS10915	COG1070	Carbohydrate kinase
GFH29_RS10935	COG0673	inositol 2-dehydrogenase activity
GFH29_RS10940	COG1879	ABC-type sugar transport system periplasmic component
GFH29_RS10945	COG1172	Belongs to the binding-protein-dependent transport system permease family
GFH29_RS10950	COG1129	ABC transporter
GFH29_RS10955	COG1940	carbohydrate kinase activity
GFH29_RS10965	COG1793	dna ligase
GFH29_RS10975	COG1131	(ABC) transporter
GFH29_RS10980	COG2197	response regulator
GFH29_RS10985	COG4585	Histidine kinase
GFH29_RS10995	COG2226	methyltransferase
GFH29_RS11000	COG0798	PFAM Bile acid sodium symporter
GFH29_RS11010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH29_RS11035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH29_RS11040	COG0488	(ABC) transporter
GFH29_RS11050	COG0183	Belongs to the thiolase family
GFH29_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS11070	COG1946	Acyl-CoA thioesterase
GFH29_RS11075	COG1946	Acyl-CoA thioesterase
GFH29_RS11085	COG0183	Belongs to the thiolase family
GFH29_RS11110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GFH29_RS11115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GFH29_RS11120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFH29_RS11125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFH29_RS11135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFH29_RS11145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFH29_RS11150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFH29_RS11170	COG4608	Belongs to the ABC transporter superfamily
GFH29_RS11180	COG0601	transmembrane transport
GFH29_RS11190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS11195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFH29_RS11200	COG0124	histidyl-tRNA synthetase
GFH29_RS11210	COG1196	nuclear chromosome segregation
GFH29_RS11215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFH29_RS11220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFH29_RS11225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH29_RS11230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GFH29_RS11240	COG2255	four-way junction helicase activity
GFH29_RS11245	COG0632	four-way junction helicase activity
GFH29_RS11250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GFH29_RS11255	COG0217	transcriptional regulatory protein
GFH29_RS11260	COG1408	metallophosphoesterase
GFH29_RS11265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFH29_RS11270	COG0483	inositol monophosphate 1-phosphatase activity
GFH29_RS11285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFH29_RS11310	COG2755	lipolytic protein G-D-S-L family
GFH29_RS11310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH29_RS11325	COG2197	response regulator
GFH29_RS11375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH29_RS11375	COG2755	lipolytic protein G-D-S-L family
GFH29_RS11475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFH29_RS11495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFH29_RS11645	COG0714	Associated with various cellular activities
GFH29_RS11655	COG3842	ATPase activity
GFH29_RS11695	COG0028	Belongs to the TPP enzyme family
GFH29_RS11730	COG3546	catalase activity
GFH29_RS11740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GFH29_RS11755	COG1755	Isoprenylcysteine carboxyl methyltransferase
GFH29_RS11765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFH29_RS11775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFH29_RS11780	COG0406	alpha-ribazole phosphatase activity
GFH29_RS11795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH29_RS11815	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS11820	COG0471	metal ion transport
GFH29_RS11825	COG0473	3-isopropylmalate dehydrogenase activity
GFH29_RS11830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFH29_RS11845	COG0175	sulfate reduction
GFH29_RS11870	COG2326	polyphosphate kinase activity
GFH29_RS11875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GFH29_RS11885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFH29_RS11905	COG1131	(ABC) transporter
GFH29_RS11915	COG1201	RNA secondary structure unwinding
GFH29_RS11920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFH29_RS11930	COG1058	Belongs to the CinA family
GFH29_RS11930	COG1546	Belongs to the CinA family
GFH29_RS11940	COG0737	Belongs to the 5'-nucleotidase family
GFH29_RS11950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH29_RS11960	COG1674	ftsk spoiiie
GFH29_RS11970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GFH29_RS11975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFH29_RS11990	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFH29_RS11995	COG0384	phenazine biosynthesis protein PhzF
GFH29_RS12005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GFH29_RS12010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFH29_RS12025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFH29_RS12030	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH29_RS12050	COG0321	lipoyl(octanoyl) transferase activity
GFH29_RS12055	COG1131	(ABC) transporter
GFH29_RS12065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GFH29_RS12085	COG0174	glutamine synthetase
GFH29_RS12130	COG0714	Associated with various cellular activities
GFH29_RS12400	COG2963	transposase activity
GFH29_RS12465	COG3361	conserved protein (COG2071)
GFH29_RS12520	COG1064	alcohol dehydrogenase
GFH29_RS12530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFH29_RS12550	COG1278	Cold shock
GFH29_RS12560	COG0586	Pfam SNARE associated Golgi protein
GFH29_RS12580	COG2072	flavoprotein involved in K transport
GFH29_RS12585	COG0657	acetylesterase activity
GFH29_RS12615	COG2072	flavoprotein involved in K transport
GFH29_RS12655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS12665	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS12675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH29_RS12690	COG4585	Histidine kinase
GFH29_RS12695	COG2197	response regulator
GFH29_RS12700	COG1136	(ABC) transporter
GFH29_RS12700	COG0577	efflux transmembrane transporter activity
GFH29_RS12740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFH29_RS12745	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GFH29_RS12750	COG1131	(ABC) transporter
GFH29_RS12755	COG3559	Exporter of polyketide antibiotics
GFH29_RS12760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH29_RS12765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GFH29_RS12810	COG0531	amino acid
GFH29_RS12815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFH29_RS12830	COG0514	ATP-dependent DNA helicase (RecQ)
GFH29_RS12845	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS12870	COG0563	adenylate kinase activity
GFH29_RS12910	COG0745	RESPONSE REGULATOR receiver
GFH29_RS12950	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GFH29_RS12960	COG0174	glutamine synthetase
GFH29_RS12970	COG2226	methyltransferase
GFH29_RS12980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GFH29_RS12985	COG1131	(ABC) transporter
GFH29_RS12995	COG4585	Histidine kinase
GFH29_RS13000	COG2197	response regulator
GFH29_RS13050	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFH29_RS13050	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
GFH29_RS13090	COG1802	Transcriptional regulator
GFH29_RS13110	COG0477	Major facilitator Superfamily
GFH29_RS13125	COG1247	-acetyltransferase
GFH29_RS13140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS13165	COG3265	gluconokinase activity
GFH29_RS13210	COG1288	antiporter activity
GFH29_RS13215	COG2235	arginine
GFH29_RS13220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFH29_RS13225	COG0549	Belongs to the carbamate kinase family
GFH29_RS13265	COG2119	membrane
GFH29_RS13280	COG3022	response to hydroperoxide
GFH29_RS13295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFH29_RS13320	COG0745	RESPONSE REGULATOR receiver
GFH29_RS13335	COG0477	Major facilitator Superfamily
GFH29_RS13350	COG2847	Copper chaperone PCu(A)C
GFH29_RS13370	COG1063	alcohol dehydrogenase
GFH29_RS13395	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS13405	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GFH29_RS13425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFH29_RS13430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFH29_RS13435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFH29_RS13480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFH29_RS13485	COG0515	serine threonine protein kinase
GFH29_RS13500	COG1414	Transcriptional regulator
GFH29_RS13505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFH29_RS13510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS13525	COG0346	lactoylglutathione lyase activity
GFH29_RS13610	COG0358	DNA primase activity
GFH29_RS13620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFH29_RS13650	COG0423	glycine-tRNA ligase activity
GFH29_RS13660	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFH29_RS13665	COG1121	(ABC) transporter
GFH29_RS13670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFH29_RS13680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH29_RS13685	COG1381	Involved in DNA repair and RecF pathway recombination
GFH29_RS13690	COG2267	carboxylic ester hydrolase activity
GFH29_RS13695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GFH29_RS13710	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH29_RS13730	COG1295	ribonuclease BN
GFH29_RS13735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFH29_RS13735	COG0723	plastoquinol--plastocyanin reductase activity
GFH29_RS13740	COG0110	maltose O-acetyltransferase activity
GFH29_RS13755	COG5002	protein histidine kinase activity
GFH29_RS13755	COG5000	phosphorelay sensor kinase activity
GFH29_RS13795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFH29_RS13805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFH29_RS13830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFH29_RS13845	COG0537	adenosine 5'-monophosphoramidase activity
GFH29_RS13870	COG0484	heat shock protein binding
GFH29_RS13875	COG1420	regulation of RNA biosynthetic process
GFH29_RS13885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH29_RS13910	COG0587	DNA-directed DNA polymerase activity
GFH29_RS13915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFH29_RS13930	COG2258	MOSC domain
GFH29_RS13935	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
GFH29_RS13940	COG0481	GTPase activity
GFH29_RS13960	COG0268	Binds directly to 16S ribosomal RNA
GFH29_RS13975	COG1555	photosystem II stabilization
GFH29_RS13980	COG1307	EDD domain protein, DegV family
GFH29_RS13985	COG0495	leucyl-tRNA aminoacylation
GFH29_RS13995	COG2072	flavoprotein involved in K transport
GFH29_RS14005	COG0783	Belongs to the Dps family
GFH29_RS14035	COG0799	negative regulation of ribosome biogenesis
GFH29_RS14040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFH29_RS14045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFH29_RS14055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GFH29_RS14095	COG0058	SHG alpha-glucan phosphorylase activity
GFH29_RS14100	COG0366	Alpha amylase catalytic
GFH29_RS14110	COG3281	Trehalose synthase
GFH29_RS14115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GFH29_RS14130	COG0583	DNA-binding transcription factor activity
GFH29_RS14150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GFH29_RS14165	COG0183	Belongs to the thiolase family
GFH29_RS14170	COG0346	lactoylglutathione lyase activity
GFH29_RS14205	COG2066	Belongs to the glutaminase family
GFH29_RS14225	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GFH29_RS14240	COG5002	protein histidine kinase activity
GFH29_RS14255	COG1528	Iron-storage protein
GFH29_RS14265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH29_RS14265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH29_RS14290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFH29_RS14295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFH29_RS14300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFH29_RS14305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFH29_RS14310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH29_RS14315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFH29_RS14320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFH29_RS14325	COG0356	it plays a direct role in the translocation of protons across the membrane
GFH29_RS14340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFH29_RS14350	COG2890	protein-(glutamine-N5) methyltransferase activity
GFH29_RS14355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFH29_RS14360	COG0254	rRNA binding
GFH29_RS14375	COG0083	homoserine kinase activity
GFH29_RS14380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GFH29_RS14385	COG0460	homoserine dehydrogenase
GFH29_RS14390	COG0019	diaminopimelate decarboxylase activity
GFH29_RS14395	COG0018	arginyl-trna synthetase
GFH29_RS14405	COG1316	TRANSCRIPTIONal
GFH29_RS14415	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH29_RS14415	COG0567	Dehydrogenase, E1 component
GFH29_RS14430	COG0604	alcohol dehydrogenase
GFH29_RS14455	COG1191	sigma factor activity
GFH29_RS14490	COG1120	ATPase activity
GFH29_RS14495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS14500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS14515	COG2207	Transcriptional regulator
GFH29_RS14525	COG1595	DNA-templated transcription, initiation
GFH29_RS14530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFH29_RS14545	COG2135	peptidase activity
GFH29_RS14555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GFH29_RS14570	COG0483	inositol monophosphate 1-phosphatase activity
GFH29_RS14580	COG0681	Belongs to the peptidase S26 family
GFH29_RS14590	COG2501	S4 domain
GFH29_RS14595	COG2733	membrane
GFH29_RS14605	COG1605	Chorismate mutase
GFH29_RS14605	COG0287	Prephenate dehydrogenase
GFH29_RS14610	COG1024	Enoyl-CoA hydratase
GFH29_RS14615	COG3119	arylsulfatase activity
GFH29_RS14640	COG1615	UPF0182 protein
GFH29_RS14650	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFH29_RS14680	COG1796	DNA polymerase
GFH29_RS14680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GFH29_RS14685	COG1024	Enoyl-CoA hydratase
GFH29_RS14745	COG0210	DNA helicase
GFH29_RS14770	COG0549	Belongs to the carbamate kinase family
GFH29_RS14775	COG3263	regulation of cellular component size
GFH29_RS14790	COG2197	response regulator
GFH29_RS14800	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS14845	COG2233	PERMEase
GFH29_RS14860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFH29_RS14865	COG1304	FMN binding
GFH29_RS14875	COG0204	Acyl-transferase
GFH29_RS14875	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS14920	COG0513	Belongs to the DEAD box helicase family
GFH29_RS14930	COG1192	Involved in chromosome partitioning
GFH29_RS14935	COG0300	oxidoreductase activity
GFH29_RS14940	COG2095	MarC family integral membrane protein
GFH29_RS14945	COG0613	PHP domain protein
GFH29_RS14960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GFH29_RS14970	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS14985	COG2239	Acts as a magnesium transporter
GFH29_RS15000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GFH29_RS15010	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS15045	COG0653	protein targeting
GFH29_RS15050	COG3214	Protein conserved in bacteria
GFH29_RS15055	COG2197	response regulator
GFH29_RS15060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GFH29_RS15065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFH29_RS15070	COG5401	PFAM Sporulation and spore germination
GFH29_RS15075	COG5002	protein histidine kinase activity
GFH29_RS15080	COG0745	RESPONSE REGULATOR receiver
GFH29_RS15085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GFH29_RS15105	COG2354	Protein conserved in bacteria
GFH29_RS15110	COG3594	Acyltransferase
GFH29_RS15120	COG1663	tetraacyldisaccharide 4'-kinase activity
GFH29_RS15120	COG2835	tetraacyldisaccharide 4'-kinase activity
GFH29_RS15155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GFH29_RS15160	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GFH29_RS15160	COG0778	Nitroreductase
GFH29_RS15185	COG1216	Glycosyl transferase, family 2
GFH29_RS15250	COG1216	Glycosyl transferase, family 2
GFH29_RS15255	COG1216	Glycosyl transferase, family 2
GFH29_RS15260	COG1316	TRANSCRIPTIONal
GFH29_RS15265	COG1607	acyl-coa hydrolase
GFH29_RS15270	COG1316	TRANSCRIPTIONal
GFH29_RS15275	COG1024	Enoyl-CoA hydratase
GFH29_RS15300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GFH29_RS15320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GFH29_RS15340	COG0783	Belongs to the Dps family
GFH29_RS15360	COG3483	tryptophan 2,3-dioxygenase activity
GFH29_RS15370	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS15395	COG0489	protein tyrosine kinase activity
GFH29_RS15405	COG1910	domain protein
GFH29_RS15410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH29_RS15430	COG2409	Drug exporters of the RND superfamily
GFH29_RS15445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GFH29_RS15455	COG1024	Enoyl-CoA hydratase
GFH29_RS15470	COG1611	Belongs to the LOG family
GFH29_RS15475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH29_RS15485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFH29_RS15495	COG2318	DinB family
GFH29_RS15510	COG2171	N-acyltransferase activity
GFH29_RS15555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH29_RS15585	COG0579	oxidoreductase
GFH29_RS15620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GFH29_RS15635	COG2267	carboxylic ester hydrolase activity
GFH29_RS15650	COG1595	DNA-templated transcription, initiation
GFH29_RS15670	COG3177	Filamentation induced by cAMP protein fic
GFH29_RS15705	COG0012	GTP binding
GFH29_RS15715	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS15720	COG0708	Exodeoxyribonuclease III
GFH29_RS15725	COG1322	Protein conserved in bacteria
GFH29_RS15735	COG0009	L-threonylcarbamoyladenylate synthase
GFH29_RS15740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GFH29_RS15745	COG1570	exodeoxyribonuclease VII activity
GFH29_RS15750	COG1722	exodeoxyribonuclease VII activity
GFH29_RS15825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH29_RS15825	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GFH29_RS15855	COG0114	fumarate hydratase activity
GFH29_RS15865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GFH29_RS15870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFH29_RS15895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFH29_RS15905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GFH29_RS15915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFH29_RS15920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GFH29_RS15935	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GFH29_RS15945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GFH29_RS15950	COG0456	acetyltransferase
GFH29_RS15955	COG1116	anion transmembrane transporter activity
GFH29_RS15965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS15970	COG2318	DinB family
GFH29_RS15985	COG1739	Uncharacterized protein family UPF0029
GFH29_RS16000	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GFH29_RS16005	COG3012	SEC-C Motif Domain Protein
GFH29_RS16015	COG0183	Belongs to the thiolase family
GFH29_RS16040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH29_RS16040	COG2755	lipolytic protein G-D-S-L family
GFH29_RS16045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GFH29_RS16055	COG0242	peptide deformylase activity
GFH29_RS16095	COG0148	phosphopyruvate hydratase activity
GFH29_RS16100	COG1832	CoA-binding protein
GFH29_RS16105	COG2080	2 iron, 2 sulfur cluster binding
GFH29_RS16110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GFH29_RS16115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GFH29_RS16125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFH29_RS16135	COG0745	RESPONSE REGULATOR receiver
GFH29_RS16140	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH29_RS16155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GFH29_RS16155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GFH29_RS16160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GFH29_RS16180	COG0745	RESPONSE REGULATOR receiver
GFH29_RS16195	COG0424	maF-like protein
GFH29_RS16205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GFH29_RS16210	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS16215	COG4770	biotin carboxylase activity
GFH29_RS16260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFH29_RS16270	COG2385	sporulation resulting in formation of a cellular spore
GFH29_RS16320	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GFH29_RS16325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFH29_RS16335	COG5398	heme oxygenase
GFH29_RS16345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH29_RS16355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFH29_RS16365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFH29_RS16395	COG1902	pentaerythritol trinitrate reductase activity
GFH29_RS16415	COG3845	ABC transporter
GFH29_RS16420	COG4603	Belongs to the binding-protein-dependent transport system permease family
GFH29_RS16425	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFH29_RS16430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GFH29_RS16430	COG1473	amidohydrolase
GFH29_RS16455	COG1053	succinate dehydrogenase
GFH29_RS16480	COG0180	Tryptophanyl-tRNA synthetase
GFH29_RS16485	COG2814	Major facilitator Superfamily
GFH29_RS16495	COG1132	(ABC) transporter
GFH29_RS16500	COG2838	Isocitrate dehydrogenase
GFH29_RS16515	COG0039	L-malate dehydrogenase activity
GFH29_RS16525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFH29_RS16530	COG0138	bifunctional purine biosynthesis protein purh
GFH29_RS16555	COG0045	succinate-CoA ligase (ADP-forming) activity
GFH29_RS16560	COG1196	nuclear chromosome segregation
GFH29_RS16560	COG0741	lytic transglycosylase activity
GFH29_RS16560	COG0739	heme binding
GFH29_RS16565	COG1472	Belongs to the glycosyl hydrolase 3 family
GFH29_RS16580	COG0589	response to stress
GFH29_RS16585	COG0531	amino acid
GFH29_RS16590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GFH29_RS16595	COG2197	response regulator
GFH29_RS16600	COG4585	Histidine kinase
GFH29_RS16615	COG0584	glycerophosphoryl diester phosphodiesterase
GFH29_RS16625	COG1132	(ABC) transporter
GFH29_RS16630	COG1132	(ABC) transporter
GFH29_RS16640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS16645	COG2755	lipolytic protein G-D-S-L family
GFH29_RS16645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH29_RS16670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS16675	COG4521	taurine ABC transporter
GFH29_RS16680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GFH29_RS16690	COG2409	Drug exporters of the RND superfamily
GFH29_RS16695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GFH29_RS16700	COG4214	carbohydrate transport
GFH29_RS16710	COG4213	ABC transporter substrate-binding protein
GFH29_RS16715	COG1940	carbohydrate kinase activity
GFH29_RS16725	COG2329	Antibiotic biosynthesis monooxygenase
GFH29_RS16745	COG0519	Catalyzes the synthesis of GMP from XMP
GFH29_RS16745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFH29_RS16755	COG1012	belongs to the aldehyde dehydrogenase family
GFH29_RS16775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GFH29_RS16785	COG0516	GMP reductase activity
GFH29_RS16805	COG0459	protein refolding
GFH29_RS16810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFH29_RS16825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GFH29_RS16845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFH29_RS16855	COG1214	PFAM Peptidase M22, glycoprotease
GFH29_RS16855	COG0456	acetyltransferase
GFH29_RS16860	COG0802	atpase or kinase
GFH29_RS16870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH29_RS16880	COG0154	amidase activity
GFH29_RS16885	COG0584	glycerophosphoryl diester phosphodiesterase
GFH29_RS16890	COG0736	holo-[acyl-carrier-protein] synthase activity
GFH29_RS16895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH29_RS16900	COG1072	(Pantothenic acid kinase))
GFH29_RS16910	COG1131	(ABC) transporter
GFH29_RS16915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFH29_RS16920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFH29_RS16925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFH29_RS16935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFH29_RS16945	COG0488	(ABC) transporter
GFH29_RS16960	COG0745	RESPONSE REGULATOR receiver
GFH29_RS16965	COG2205	protein histidine kinase activity
GFH29_RS16970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GFH29_RS16990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GFH29_RS17005	COG4129	membrane
GFH29_RS17055	COG0753	catalase activity
GFH29_RS17120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFH29_RS17125	COG1902	pentaerythritol trinitrate reductase activity
GFH29_RS17130	COG0477	Major facilitator Superfamily
GFH29_RS17155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFH29_RS17160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFH29_RS17175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFH29_RS17195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFH29_RS17205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFH29_RS17215	COG0405	Gamma-glutamyltransferase
GFH29_RS17220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH29_RS17235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFH29_RS17245	COG0589	response to stress
GFH29_RS17285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GFH29_RS17300	COG1126	abc transporter atp-binding protein
GFH29_RS17305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFH29_RS17310	COG0765	amino acid transport
GFH29_RS17315	COG0765	amino acid transport
GFH29_RS17340	COG4106	trans-aconitate 2-methyltransferase activity
GFH29_RS17350	COG0488	(ABC) transporter
GFH29_RS17355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFH29_RS17360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFH29_RS17365	COG3583	domain protein
GFH29_RS17370	COG0084	hydrolase, TatD family'
GFH29_RS17375	COG2267	carboxylic ester hydrolase activity
GFH29_RS17400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFH29_RS17440	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFH29_RS17445	COG0315	cyclic pyranopterin monophosphate synthase activity
GFH29_RS17460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFH29_RS17485	COG1970	mechanosensitive ion channel activity
GFH29_RS17500	COG0366	Alpha amylase catalytic
GFH29_RS17545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFH29_RS17550	COG0215	cysteine-tRNA ligase activity
GFH29_RS17565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH29_RS17570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFH29_RS17585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GFH29_RS17595	COG1329	Transcriptional regulator
GFH29_RS17610	COG0588	phosphoglycerate mutase activity
GFH29_RS17620	COG5002	protein histidine kinase activity
GFH29_RS17640	COG0438	transferase activity, transferring glycosyl groups
GFH29_RS17655	COG1794	racemase activity, acting on amino acids and derivatives
GFH29_RS17680	COG1217	gtp-binding protein TYPA
GFH29_RS17690	COG3842	ATPase activity
GFH29_RS17705	COG0395	ABC-type sugar transport system, permease component
GFH29_RS17735	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS17740	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS17750	COG2188	Transcriptional regulator
GFH29_RS17765	COG0659	secondary active sulfate transmembrane transporter activity
GFH29_RS17775	COG0747	negative chemotaxis
GFH29_RS17780	COG0601	transmembrane transport
GFH29_RS17785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFH29_RS17790	COG0444	Belongs to the ABC transporter superfamily
GFH29_RS17795	COG4608	Belongs to the ABC transporter superfamily
GFH29_RS17815	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS17865	COG1024	Enoyl-CoA hydratase
GFH29_RS17870	COG0183	Belongs to the thiolase family
GFH29_RS17880	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH29_RS17880	COG1703	isobutyryl-CoA mutase activity
GFH29_RS17880	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GFH29_RS17900	COG1024	Enoyl-CoA hydratase
GFH29_RS17945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFH29_RS17950	COG0463	Glycosyl transferase, family 2
GFH29_RS17975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFH29_RS17980	COG1088	dTDP-glucose 4,6-dehydratase activity
GFH29_RS18015	COG0529	Catalyzes the synthesis of activated sulfate
GFH29_RS18020	COG0730	response to heat
GFH29_RS18060	COG1045	serine acetyltransferase
GFH29_RS18070	COG2897	thiosulfate sulfurtransferase activity
GFH29_RS18100	COG0745	RESPONSE REGULATOR receiver
GFH29_RS18120	COG0735	belongs to the Fur family
GFH29_RS18125	COG4044	May play a role in the intracellular transport of hydrophobic ligands
GFH29_RS18135	COG1490	D-aminoacyl-tRNA deacylase activity
GFH29_RS18145	COG0489	protein tyrosine kinase activity
GFH29_RS18150	COG0454	-acetyltransferase
GFH29_RS18150	COG0456	acetyltransferase
GFH29_RS18165	COG1088	dTDP-glucose 4,6-dehydratase activity
GFH29_RS18170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFH29_RS18175	COG0657	acetylesterase activity
GFH29_RS18180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GFH29_RS18200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFH29_RS18245	COG1937	Protein conserved in bacteria
GFH29_RS18255	COG1278	Cold shock
GFH29_RS18280	COG0154	amidase activity
GFH29_RS18300	COG3119	arylsulfatase activity
GFH29_RS18315	COG0531	amino acid
GFH29_RS18335	COG0531	amino acid
GFH29_RS18365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFH29_RS18415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFH29_RS18415	COG0574	Belongs to the PEP-utilizing enzyme family
GFH29_RS18420	COG0589	response to stress
GFH29_RS18445	COG1271	oxidase subunit
GFH29_RS18450	COG1294	oxidase, subunit
GFH29_RS18455	COG4988	ABC transporter
GFH29_RS18475	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS18480	COG4251	negative regulation of phosphorylation
GFH29_RS18495	COG1252	NADH dehydrogenase
GFH29_RS18545	COG2205	protein histidine kinase activity
GFH29_RS18545	COG5002	protein histidine kinase activity
GFH29_RS18545	COG0784	Response regulator, receiver
GFH29_RS18565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFH29_RS18610	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS18620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFH29_RS18630	COG2409	Drug exporters of the RND superfamily
GFH29_RS18635	COG0047	phosphoribosylformylglycinamidine synthase activity
GFH29_RS18640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFH29_RS18650	COG0318	PFAM AMP-dependent synthetase and ligase
GFH29_RS18660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFH29_RS18670	COG0477	Major facilitator Superfamily
GFH29_RS18690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFH29_RS18695	COG0151	Belongs to the GarS family
GFH29_RS18700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFH29_RS18710	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GFH29_RS18715	COG2855	membrane
GFH29_RS18750	COG0586	Pfam SNARE associated Golgi protein
GFH29_RS18755	COG0586	Pfam SNARE associated Golgi protein
GFH29_RS18760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GFH29_RS18775	COG0542	response to heat
GFH29_RS18785	COG0789	Transcriptional regulator
GFH29_RS18790	COG0484	heat shock protein binding
GFH29_RS18795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFH29_RS18800	COG0443	Heat shock 70 kDa protein
GFH29_RS18825	COG0656	L-ascorbic acid biosynthetic process
GFH29_RS18830	COG1846	Transcriptional regulator
GFH29_RS18835	COG0697	spore germination
GFH29_RS18845	COG0748	coenzyme F420 binding
GFH29_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS18880	COG0454	-acetyltransferase
GFH29_RS18915	COG2072	flavoprotein involved in K transport
GFH29_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
GFH29_RS18930	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GFH29_RS18930	COG1672	PFAM Archaeal ATPase
GFH29_RS18940	COG1228	amidohydrolase
GFH29_RS18960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFH29_RS18975	COG2301	Belongs to the HpcH HpaI aldolase family
GFH29_RS18980	COG2301	Belongs to the HpcH HpaI aldolase family
GFH29_RS19005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFH29_RS19020	COG1846	Transcriptional regulator
GFH29_RS19095	COG0346	lactoylglutathione lyase activity
GFH29_RS19120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFH29_RS19155	COG1024	Enoyl-CoA hydratase
GFH29_RS19165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS19180	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS19190	COG0179	Fumarylacetoacetate (FAA) hydrolase
GFH29_RS19205	COG2814	Major facilitator Superfamily
GFH29_RS19225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS19240	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GFH29_RS19255	COG2181	nitrate reductase activity
GFH29_RS19255	COG0247	lactate metabolic process
GFH29_RS19290	COG0717	Belongs to the dCTP deaminase family
GFH29_RS19335	COG0730	response to heat
GFH29_RS19340	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS19345	COG2111	Na H antiporter
GFH29_RS19345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GFH29_RS19350	COG1006	Multisubunit Na H antiporter MnhC subunit
GFH29_RS19355	COG0651	ATP synthesis coupled electron transport
GFH29_RS19365	COG2212	antiporter activity
GFH29_RS19370	COG1320	monovalent cation:proton antiporter activity
GFH29_RS19415	COG1131	(ABC) transporter
GFH29_RS19435	COG0745	RESPONSE REGULATOR receiver
GFH29_RS19455	COG3340	Belongs to the peptidase S51 family
GFH29_RS19475	COG2755	lipolytic protein G-D-S-L family
GFH29_RS19480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFH29_RS19505	COG2826	transposase and inactivated derivatives, IS30 family
GFH29_RS19540	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFH29_RS19545	COG0022	dehydrogenase e1 component
GFH29_RS19575	COG0435	Glutathione S-transferase
GFH29_RS19585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GFH29_RS19595	COG1802	Transcriptional regulator
GFH29_RS19600	COG1950	PFAM Membrane protein of
GFH29_RS19605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFH29_RS19635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFH29_RS19640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GFH29_RS19640	COG0512	Glutamine amidotransferase of anthranilate synthase
GFH29_RS19685	COG1024	Enoyl-CoA hydratase
GFH29_RS19690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GFH29_RS19700	COG1595	DNA-templated transcription, initiation
GFH29_RS19710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GFH29_RS19725	COG2365	Tyrosine phosphatase family
GFH29_RS19740	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS19760	COG0577	efflux transmembrane transporter activity
GFH29_RS19760	COG1136	(ABC) transporter
GFH29_RS19770	COG1695	Transcriptional regulator
GFH29_RS19780	COG1024	Enoyl-CoA hydratase
GFH29_RS19780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GFH29_RS19785	COG0183	Belongs to the thiolase family
GFH29_RS19795	COG0702	epimerase
GFH29_RS19805	COG0513	Belongs to the DEAD box helicase family
GFH29_RS19830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GFH29_RS19840	COG0765	amino acid transport
GFH29_RS19855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFH29_RS19855	COG1902	pentaerythritol trinitrate reductase activity
GFH29_RS19860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFH29_RS19870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFH29_RS19875	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFH29_RS19880	COG2755	lipolytic protein G-D-S-L family
GFH29_RS19880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFH29_RS19885	COG4585	Histidine kinase
GFH29_RS19890	COG2197	response regulator
GFH29_RS19935	COG2268	Band 7 protein
GFH29_RS19945	COG0768	penicillin binding
GFH29_RS19970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFH29_RS19985	COG2353	YceI-like domain
GFH29_RS19990	COG0456	acetyltransferase
GFH29_RS19995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS20010	COG1643	Atp-dependent helicase
GFH29_RS20015	COG1960	acyl-CoA dehydrogenase activity
GFH29_RS20050	COG0339	signal peptide processing
GFH29_RS20075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFH29_RS20080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFH29_RS20095	COG2234	aminopeptidase activity
GFH29_RS20105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GFH29_RS20110	COG2031	fatty acid transporter
GFH29_RS20115	COG0579	oxidoreductase
GFH29_RS20130	COG4941	Belongs to the sigma-70 factor family
GFH29_RS20135	COG3795	YCII-related domain
GFH29_RS20165	COG1271	oxidase subunit
GFH29_RS20180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GFH29_RS20190	COG0305	Participates in initiation and elongation during chromosome replication
GFH29_RS20195	COG0534	Mate efflux family protein
GFH29_RS20215	COG0359	binds to the 23S rRNA
GFH29_RS20220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFH29_RS20225	COG0629	single-stranded DNA binding
GFH29_RS20230	COG0360	Binds together with S18 to 16S ribosomal RNA
GFH29_RS20235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFH29_RS20255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFH29_RS20265	COG1260	myo-inositol-1-phosphate synthase
GFH29_RS20275	COG0617	tRNA 3'-terminal CCA addition
GFH29_RS20295	COG1595	DNA-templated transcription, initiation
GFH29_RS20305	COG0492	ferredoxin-NADP+ reductase activity
GFH29_RS20310	COG3118	belongs to the thioredoxin family
GFH29_RS20335	COG1192	Involved in chromosome partitioning
GFH29_RS20340	COG0357	Ribosomal RNA small subunit methyltransferase G
GFH29_RS20350	COG0706	membrane insertase activity
GFH29_RS20355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFH29_RS20360	COG0594	ribonuclease P activity
GFH29_RS20365	COG0230	Belongs to the bacterial ribosomal protein bL34 family