locus-tag	class	description
H0S67_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H0S67_RS00010	COG0592	DNA-directed DNA polymerase activity
H0S67_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H0S67_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0S67_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
H0S67_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0S67_RS00110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0S67_RS00115	COG0457	Tetratricopeptide repeat
H0S67_RS00115	COG0705	Rhomboid family
H0S67_RS00130	COG0515	serine threonine protein kinase
H0S67_RS00155	COG1716	ATPase activity
H0S67_RS00160	COG1716	ATPase activity
H0S67_RS00185	COG0783	Belongs to the Dps family
H0S67_RS00205	COG0745	RESPONSE REGULATOR receiver
H0S67_RS00220	COG0386	Belongs to the glutathione peroxidase family
H0S67_RS00250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H0S67_RS00300	COG5012	cobalamin binding
H0S67_RS00310	COG5598	trimethylamine methyltransferase
H0S67_RS00320	COG1414	Transcriptional regulator
H0S67_RS00325	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS00335	COG4175	Glycine betaine
H0S67_RS00335	COG0517	IMP dehydrogenase activity
H0S67_RS00340	COG4176	ABC-type proline glycine betaine transport system permease component
H0S67_RS00355	COG2086	electron transfer activity
H0S67_RS00360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0S67_RS00385	COG3590	peptidase
H0S67_RS00395	COG0642	Histidine kinase
H0S67_RS00405	COG0514	ATP-dependent DNA helicase (RecQ)
H0S67_RS00410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H0S67_RS00410	COG2755	lipolytic protein G-D-S-L family
H0S67_RS00415	COG1215	transferase activity, transferring glycosyl groups
H0S67_RS00420	COG0477	Major facilitator Superfamily
H0S67_RS00425	COG0386	Belongs to the glutathione peroxidase family
H0S67_RS00430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S67_RS00445	COG1937	Protein conserved in bacteria
H0S67_RS00455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0S67_RS00460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0S67_RS00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0S67_RS00465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S67_RS00470	COG0730	response to heat
H0S67_RS00480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S67_RS00530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0S67_RS00555	COG0653	protein targeting
H0S67_RS00565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H0S67_RS00575	COG2235	arginine
H0S67_RS00585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H0S67_RS00620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H0S67_RS00640	COG1597	lipid kinase activity
H0S67_RS00640	COG1803	Methylglyoxal synthase
H0S67_RS00650	COG0561	phosphatase activity
H0S67_RS00660	COG0561	phosphatase activity
H0S67_RS00690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H0S67_RS00735	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H0S67_RS00760	COG0287	Prephenate dehydrogenase
H0S67_RS00760	COG1605	Chorismate mutase
H0S67_RS00765	COG0583	DNA-binding transcription factor activity
H0S67_RS00770	COG2814	Major facilitator Superfamily
H0S67_RS00780	COG1522	sequence-specific DNA binding
H0S67_RS00790	COG0022	dehydrogenase e1 component
H0S67_RS00795	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S67_RS00805	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS00805	COG2030	dehydratase
H0S67_RS00810	COG3396	Phenylacetate-CoA oxygenase
H0S67_RS00815	COG3460	Phenylacetate-CoA oxygenase
H0S67_RS00830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S67_RS00835	COG1024	Enoyl-CoA hydratase
H0S67_RS00845	COG2050	protein possibly involved in aromatic compounds catabolism
H0S67_RS00860	COG2201	protein-glutamate methylesterase activity
H0S67_RS00885	COG3485	protocatechuate 3,4-dioxygenase
H0S67_RS00900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S67_RS00910	COG0346	lactoylglutathione lyase activity
H0S67_RS00925	COG0183	Belongs to the thiolase family
H0S67_RS01010	COG2318	DinB family
H0S67_RS01075	COG3485	protocatechuate 3,4-dioxygenase
H0S67_RS01080	COG1454	alcohol dehydrogenase
H0S67_RS01085	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H0S67_RS01085	COG1672	PFAM Archaeal ATPase
H0S67_RS01095	COG2226	methyltransferase
H0S67_RS01105	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H0S67_RS01120	COG0281	malic enzyme
H0S67_RS01150	COG2226	methyltransferase
H0S67_RS01165	COG0477	Major facilitator Superfamily
H0S67_RS01210	COG3132	Protein of unknown function, DUF480
H0S67_RS01250	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H0S67_RS01255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H0S67_RS01270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0S67_RS01275	COG1120	ATPase activity
H0S67_RS01290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0S67_RS01335	COG1278	Cold shock
H0S67_RS01345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H0S67_RS01385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H0S67_RS01425	COG0477	Major facilitator Superfamily
H0S67_RS01430	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS01440	COG1609	Transcriptional regulator
H0S67_RS01445	COG2182	Extracellular solute-binding protein
H0S67_RS01455	COG3833	ABC-type maltose transport systems, permease component
H0S67_RS01485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0S67_RS01495	COG0590	tRNA wobble adenosine to inosine editing
H0S67_RS01500	COG3250	beta-galactosidase activity
H0S67_RS01510	COG1309	transcriptional regulator
H0S67_RS01545	COG2814	Major facilitator Superfamily
H0S67_RS01570	COG1595	DNA-templated transcription, initiation
H0S67_RS01595	COG2066	Belongs to the glutaminase family
H0S67_RS01620	COG1172	Belongs to the binding-protein-dependent transport system permease family
H0S67_RS01645	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS01650	COG0346	lactoylglutathione lyase activity
H0S67_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS01670	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S67_RS01725	COG2197	response regulator
H0S67_RS01790	COG1073	alpha beta
H0S67_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS01805	COG1609	Transcriptional regulator
H0S67_RS01810	COG1129	ABC transporter
H0S67_RS01830	COG3254	rhamnose metabolic process
H0S67_RS01840	COG3347	Dehydrogenase
H0S67_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS01845	COG1070	Carbohydrate kinase
H0S67_RS01850	COG0247	lactate metabolic process
H0S67_RS01855	COG1139	Iron-sulfur cluster binding protein
H0S67_RS01860	COG1556	Lactate utilization protein
H0S67_RS01870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0S67_RS01910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0S67_RS01925	COG1131	(ABC) transporter
H0S67_RS01930	COG1024	Enoyl-CoA hydratase
H0S67_RS01985	COG3263	regulation of cellular component size
H0S67_RS02025	COG3266	domain, Protein
H0S67_RS02030	COG0252	asparaginase activity
H0S67_RS02050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0S67_RS02055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0S67_RS02095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S67_RS02145	COG0251	oxidation-reduction process
H0S67_RS02185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0S67_RS02190	COG0494	nUDIX hydrolase
H0S67_RS02205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0S67_RS02210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S67_RS02230	COG3835	regulator
H0S67_RS02235	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS02240	COG0531	amino acid
H0S67_RS02245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0S67_RS02250	COG0686	Belongs to the AlaDH PNT family
H0S67_RS02255	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H0S67_RS02270	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0S67_RS02280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S67_RS02285	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS02390	COG1111	helicase
H0S67_RS02390	COG1205	dead DEAH box helicase
H0S67_RS02395	COG1366	Belongs to the anti-sigma-factor antagonist family
H0S67_RS02400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H0S67_RS02410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H0S67_RS02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0S67_RS02420	COG1754	DNA topoisomerase type I activity
H0S67_RS02425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0S67_RS02430	COG0470	DNA polymerase III
H0S67_RS02460	COG0477	Major facilitator Superfamily
H0S67_RS02485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0S67_RS02490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0S67_RS02495	COG0156	8-amino-7-oxononanoate synthase activity
H0S67_RS02500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0S67_RS02525	COG2323	membrane
H0S67_RS02530	COG4251	negative regulation of phosphorylation
H0S67_RS02570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S67_RS02575	COG3387	PFAM Glycoside hydrolase 15-related
H0S67_RS02600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H0S67_RS02605	COG1595	DNA-templated transcription, initiation
H0S67_RS02620	COG3842	ATPase activity
H0S67_RS02640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0S67_RS02645	COG2027	D-alanyl-D-alanine carboxypeptidase
H0S67_RS02650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0S67_RS02655	COG0037	tRNA processing
H0S67_RS02685	COG0302	gtp cyclohydrolase
H0S67_RS02695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H0S67_RS02720	COG1125	glycine betaine transport
H0S67_RS02720	COG0517	IMP dehydrogenase activity
H0S67_RS02725	COG1174	glycine betaine transport
H0S67_RS02730	COG4176	ABC-type proline glycine betaine transport system permease component
H0S67_RS02740	COG1216	Glycosyl transferase, family 2
H0S67_RS02770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H0S67_RS02775	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0S67_RS02780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H0S67_RS02790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0S67_RS02815	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H0S67_RS02820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0S67_RS02830	COG2226	methyltransferase
H0S67_RS02845	COG0248	Ppx GppA phosphatase
H0S67_RS02850	COG1082	Xylose isomerase domain protein TIM barrel
H0S67_RS02860	COG0842	Transport permease protein
H0S67_RS02860	COG1129	ABC transporter
H0S67_RS02870	COG0506	proline dehydrogenase activity
H0S67_RS02875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0S67_RS02880	COG0596	Alpha beta hydrolase
H0S67_RS02885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H0S67_RS02890	COG0180	Tryptophanyl-tRNA synthetase
H0S67_RS02895	COG0123	including yeast histone deacetylase and acetoin utilization protein
H0S67_RS02930	COG1595	DNA-templated transcription, initiation
H0S67_RS02950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H0S67_RS02955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0S67_RS02960	COG0181	hydroxymethylbilane synthase activity
H0S67_RS02965	COG1648	precorrin-2 dehydrogenase activity
H0S67_RS02965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S67_RS02970	COG0113	porphobilinogen synthase activity
H0S67_RS02985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0S67_RS02990	COG0406	alpha-ribazole phosphatase activity
H0S67_RS02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H0S67_RS03000	COG0785	Cytochrome C biogenesis protein
H0S67_RS03010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0S67_RS03075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H0S67_RS03095	COG2226	methyltransferase
H0S67_RS03105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S67_RS03110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S67_RS03115	COG0649	NAD binding
H0S67_RS03125	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S67_RS03140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0S67_RS03145	COG0839	Belongs to the complex I subunit 6 family
H0S67_RS03150	COG0713	ATP synthesis coupled electron transport
H0S67_RS03170	COG0142	geranyltranstransferase activity
H0S67_RS03190	COG0674	pyruvate-flavodoxin oxidoreductase activity
H0S67_RS03190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H0S67_RS03195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H0S67_RS03200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H0S67_RS03205	COG4208	sulfate ABC transporter
H0S67_RS03210	COG3842	ATPase activity
H0S67_RS03215	COG1666	GTP binding
H0S67_RS03230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0S67_RS03235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H0S67_RS03255	COG0318	PFAM AMP-dependent synthetase and ligase
H0S67_RS03265	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS03280	COG0277	FAD linked oxidase domain protein
H0S67_RS03285	COG0277	FAD linked oxidase domain protein
H0S67_RS03290	COG0247	lactate metabolic process
H0S67_RS03295	COG1620	l-lactate permease
H0S67_RS03315	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS03320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0S67_RS03345	COG3842	ATPase activity
H0S67_RS03350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0S67_RS03395	COG0519	Catalyzes the synthesis of GMP from XMP
H0S67_RS03405	COG0800	Aldolase
H0S67_RS03420	COG1940	carbohydrate kinase activity
H0S67_RS03445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0S67_RS03450	COG2030	dehydratase
H0S67_RS03460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0S67_RS03470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S67_RS03475	COG0436	Aminotransferase
H0S67_RS03490	COG0250	Participates in transcription elongation, termination and antitermination
H0S67_RS03495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0S67_RS03505	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0S67_RS03510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0S67_RS03515	COG0222	ribosome binding
H0S67_RS03525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S67_RS03530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0S67_RS03570	COG0484	heat shock protein binding
H0S67_RS03575	COG0085	RNA polymerase activity
H0S67_RS03580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0S67_RS03600	COG0277	FAD linked oxidase domain protein
H0S67_RS03600	COG0247	lactate metabolic process
H0S67_RS03625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H0S67_RS03630	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0S67_RS03645	COG2226	methyltransferase
H0S67_RS03685	COG0259	pyridoxamine-phosphate oxidase activity
H0S67_RS03705	COG0477	Major facilitator Superfamily
H0S67_RS03715	COG0366	Alpha amylase catalytic
H0S67_RS03725	COG0415	Belongs to the DNA photolyase family
H0S67_RS03745	COG3268	Saccharopine dehydrogenase
H0S67_RS03770	COG0018	arginyl-trna synthetase
H0S67_RS03775	COG1316	TRANSCRIPTIONal
H0S67_RS03835	COG3408	Glycogen debranching enzyme
H0S67_RS03835	COG3119	arylsulfatase activity
H0S67_RS03890	COG0596	Alpha beta hydrolase
H0S67_RS03900	COG3583	domain protein
H0S67_RS03905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0S67_RS03910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H0S67_RS03915	COG0488	(ABC) transporter
H0S67_RS03925	COG4106	trans-aconitate 2-methyltransferase activity
H0S67_RS03940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S67_RS03945	COG0647	UMP catabolic process
H0S67_RS03990	COG0726	polysaccharide deacetylase
H0S67_RS04000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS04040	COG0667	Aldo Keto reductase
H0S67_RS04055	COG2205	protein histidine kinase activity
H0S67_RS04055	COG5002	protein histidine kinase activity
H0S67_RS04055	COG0784	Response regulator, receiver
H0S67_RS04060	COG0515	serine threonine protein kinase
H0S67_RS04065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0S67_RS04115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0S67_RS04120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0S67_RS04150	COG0318	PFAM AMP-dependent synthetase and ligase
H0S67_RS04190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0S67_RS04195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0S67_RS04210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0S67_RS04230	COG1072	(Pantothenic acid kinase))
H0S67_RS04240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H0S67_RS04275	COG2205	protein histidine kinase activity
H0S67_RS04280	COG0745	RESPONSE REGULATOR receiver
H0S67_RS04310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H0S67_RS04320	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS04345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0S67_RS04445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H0S67_RS04460	COG1525	nuclease
H0S67_RS04500	COG2072	flavoprotein involved in K transport
H0S67_RS04510	COG2608	mercury ion transmembrane transporter activity
H0S67_RS04520	COG3119	arylsulfatase activity
H0S67_RS04530	COG1335	isochorismatase
H0S67_RS04620	COG1902	pentaerythritol trinitrate reductase activity
H0S67_RS04650	COG0297	glycogen (starch) synthase activity
H0S67_RS04655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H0S67_RS04660	COG3663	DNA glycosylase
H0S67_RS04735	COG4129	membrane
H0S67_RS04745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H0S67_RS04765	COG2072	flavoprotein involved in K transport
H0S67_RS04770	COG1309	transcriptional regulator
H0S67_RS04780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H0S67_RS04790	COG0745	RESPONSE REGULATOR receiver
H0S67_RS04800	COG1643	Atp-dependent helicase
H0S67_RS04865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS04875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S67_RS04915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS04920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0S67_RS04940	COG3152	Membrane
H0S67_RS04950	COG2318	DinB family
H0S67_RS04960	COG1793	dna ligase
H0S67_RS04985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0S67_RS04990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S67_RS05000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0S67_RS05005	COG0193	aminoacyl-tRNA hydrolase activity
H0S67_RS05010	COG1218	3'(2'),5'-bisphosphate nucleotidase
H0S67_RS05030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H0S67_RS05035	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS05040	COG0367	asparagine synthase
H0S67_RS05075	COG1442	glycosyl transferase family 8
H0S67_RS05075	COG1216	Glycosyl transferase, family 2
H0S67_RS05090	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H0S67_RS05110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS05115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0S67_RS05155	COG3956	TIGRFAM MazG family protein
H0S67_RS05165	COG0148	phosphopyruvate hydratase activity
H0S67_RS05230	COG1174	glycine betaine transport
H0S67_RS05240	COG1174	glycine betaine transport
H0S67_RS05245	COG1732	Glycine betaine
H0S67_RS05255	COG1294	oxidase, subunit
H0S67_RS05260	COG4988	ABC transporter
H0S67_RS05300	COG2239	Acts as a magnesium transporter
H0S67_RS05310	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
H0S67_RS05330	COG1739	Uncharacterized protein family UPF0029
H0S67_RS05340	COG2318	DinB family
H0S67_RS05355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S67_RS05375	COG0745	RESPONSE REGULATOR receiver
H0S67_RS05510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0S67_RS05520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS05540	COG0586	Pfam SNARE associated Golgi protein
H0S67_RS05550	COG3511	phospholipase C
H0S67_RS05590	COG0577	efflux transmembrane transporter activity
H0S67_RS05590	COG1136	(ABC) transporter
H0S67_RS05595	COG1136	(ABC) transporter
H0S67_RS05605	COG0745	RESPONSE REGULATOR receiver
H0S67_RS05610	COG1331	Highly conserved protein containing a thioredoxin domain
H0S67_RS05630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S67_RS05650	COG0114	fumarate hydratase activity
H0S67_RS05695	COG3842	ATPase activity
H0S67_RS05750	COG1722	exodeoxyribonuclease VII activity
H0S67_RS05795	COG0667	Aldo Keto reductase
H0S67_RS05815	COG0076	glutamate decarboxylase activity
H0S67_RS05840	COG4585	Histidine kinase
H0S67_RS05845	COG4585	Histidine kinase
H0S67_RS05850	COG2197	response regulator
H0S67_RS05870	COG2385	sporulation resulting in formation of a cellular spore
H0S67_RS05880	COG4941	Belongs to the sigma-70 factor family
H0S67_RS05905	COG2226	methyltransferase
H0S67_RS05925	COG2385	sporulation resulting in formation of a cellular spore
H0S67_RS05935	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H0S67_RS05975	COG0424	maF-like protein
H0S67_RS05995	COG0745	RESPONSE REGULATOR receiver
H0S67_RS06005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S67_RS06020	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H0S67_RS06025	COG0745	RESPONSE REGULATOR receiver
H0S67_RS06040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S67_RS06045	COG1832	CoA-binding protein
H0S67_RS06085	COG1024	Enoyl-CoA hydratase
H0S67_RS06090	COG1316	TRANSCRIPTIONal
H0S67_RS06130	COG1216	Glycosyl transferase, family 2
H0S67_RS06135	COG1216	Glycosyl transferase, family 2
H0S67_RS06145	COG1216	Glycosyl transferase, family 2
H0S67_RS06185	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H0S67_RS06185	COG0778	Nitroreductase
H0S67_RS06190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H0S67_RS06220	COG2835	tetraacyldisaccharide 4'-kinase activity
H0S67_RS06230	COG3594	Acyltransferase
H0S67_RS06240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H0S67_RS06245	COG0745	RESPONSE REGULATOR receiver
H0S67_RS06250	COG5002	protein histidine kinase activity
H0S67_RS06250	COG5000	phosphorelay sensor kinase activity
H0S67_RS06255	COG5401	PFAM Sporulation and spore germination
H0S67_RS06265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H0S67_RS06270	COG2197	response regulator
H0S67_RS06275	COG3214	Protein conserved in bacteria
H0S67_RS06280	COG1819	glycosyl
H0S67_RS06305	COG4166	transmembrane transport
H0S67_RS06315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0S67_RS06340	COG3119	arylsulfatase activity
H0S67_RS06345	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S67_RS06390	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS06410	COG2826	transposase and inactivated derivatives, IS30 family
H0S67_RS06435	COG3104	oligopeptide transport
H0S67_RS06460	COG0613	PHP domain protein
H0S67_RS06465	COG2095	MarC family integral membrane protein
H0S67_RS06485	COG0300	oxidoreductase activity
H0S67_RS06490	COG1192	Involved in chromosome partitioning
H0S67_RS06500	COG0513	Belongs to the DEAD box helicase family
H0S67_RS06510	COG2261	transglycosylase associated protein
H0S67_RS06520	COG1309	transcriptional regulator
H0S67_RS06585	COG1304	FMN binding
H0S67_RS06590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0S67_RS06605	COG2233	PERMEase
H0S67_RS06630	COG0154	amidase activity
H0S67_RS06675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0S67_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS06725	COG0813	purine-nucleoside phosphorylase activity
H0S67_RS06785	COG1796	DNA polymerase
H0S67_RS06785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H0S67_RS06815	COG3480	Lon protease (S16) C-terminal proteolytic domain
H0S67_RS06825	COG1615	UPF0182 protein
H0S67_RS06985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS06990	COG1942	4-Oxalocrotonate Tautomerase
H0S67_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS07000	COG0596	Alpha beta hydrolase
H0S67_RS07020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S67_RS07025	COG1802	Transcriptional regulator
H0S67_RS07035	COG0596	Alpha beta hydrolase
H0S67_RS07035	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S67_RS07070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H0S67_RS07095	COG4974	Belongs to the 'phage' integrase family
H0S67_RS07300	COG0581	inorganic phosphate transmembrane transporter activity
H0S67_RS07305	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0S67_RS07440	COG0358	DNA primase activity
H0S67_RS07460	COG4585	Histidine kinase
H0S67_RS07465	COG2197	response regulator
H0S67_RS07470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S67_RS07490	COG0277	FAD linked oxidase domain protein
H0S67_RS07535	COG4585	Histidine kinase
H0S67_RS07540	COG2197	response regulator
H0S67_RS07605	COG0596	Alpha beta hydrolase
H0S67_RS07610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H0S67_RS07665	COG4585	Histidine kinase
H0S67_RS07695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H0S67_RS07710	COG0492	ferredoxin-NADP+ reductase activity
H0S67_RS07715	COG2813	Specifically methylates the guanine in position
H0S67_RS07720	COG1595	DNA-templated transcription, initiation
H0S67_RS07730	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
H0S67_RS07740	COG1733	regulation of RNA biosynthetic process
H0S67_RS07750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0S67_RS07760	COG2409	Drug exporters of the RND superfamily
H0S67_RS07815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0S67_RS07830	COG3227	Zinc metalloprotease (Elastase)
H0S67_RS07880	COG0543	2 iron, 2 sulfur cluster binding
H0S67_RS07900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S67_RS07925	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H0S67_RS07930	COG0328	RNA-DNA hybrid ribonuclease activity
H0S67_RS07935	COG2197	response regulator
H0S67_RS07950	COG2066	Belongs to the glutaminase family
H0S67_RS07965	COG1162	GTPase activity
H0S67_RS08035	COG1131	(ABC) transporter
H0S67_RS08040	COG2197	response regulator
H0S67_RS08045	COG4585	Histidine kinase
H0S67_RS08060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S67_RS08065	COG0494	nUDIX hydrolase
H0S67_RS08085	COG0309	Hydrogenase expression formation protein (HypE)
H0S67_RS08095	COG0298	carbon dioxide binding
H0S67_RS08100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H0S67_RS08105	COG0439	Biotin carboxylase
H0S67_RS08115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H0S67_RS08120	COG5002	protein histidine kinase activity
H0S67_RS08125	COG0745	RESPONSE REGULATOR receiver
H0S67_RS08215	COG1136	(ABC) transporter
H0S67_RS08265	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H0S67_RS08270	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
H0S67_RS08300	COG0121	glutamine amidotransferase
H0S67_RS08315	COG0243	molybdopterin cofactor binding
H0S67_RS08315	COG3383	formate dehydrogenase (NAD+) activity
H0S67_RS08320	COG0437	4 iron, 4 sulfur cluster binding
H0S67_RS08330	COG0709	Synthesizes selenophosphate from selenide and ATP
H0S67_RS08405	COG2501	S4 domain
H0S67_RS08420	COG0483	inositol monophosphate 1-phosphatase activity
H0S67_RS08455	COG2135	peptidase activity
H0S67_RS08465	COG1595	DNA-templated transcription, initiation
H0S67_RS08535	COG0604	alcohol dehydrogenase
H0S67_RS08590	COG0018	arginyl-trna synthetase
H0S67_RS08595	COG0019	diaminopimelate decarboxylase activity
H0S67_RS08610	COG0083	homoserine kinase activity
H0S67_RS08635	COG0254	rRNA binding
H0S67_RS08640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0S67_RS08655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0S67_RS08670	COG0356	it plays a direct role in the translocation of protons across the membrane
H0S67_RS08675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0S67_RS08680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0S67_RS08685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0S67_RS08690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H0S67_RS08695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0S67_RS08700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0S67_RS08705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0S67_RS08730	COG0738	Major facilitator superfamily
H0S67_RS08740	COG1126	abc transporter atp-binding protein
H0S67_RS08745	COG0765	amino acid transport
H0S67_RS08750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0S67_RS08800	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H0S67_RS08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
H0S67_RS08890	COG0346	lactoylglutathione lyase activity
H0S67_RS08895	COG0183	Belongs to the thiolase family
H0S67_RS08930	COG1846	Transcriptional regulator
H0S67_RS08970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H0S67_RS08970	COG0574	Belongs to the PEP-utilizing enzyme family
H0S67_RS08990	COG3281	Trehalose synthase
H0S67_RS09020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S67_RS09030	COG3290	protein histidine kinase activity
H0S67_RS09035	COG4565	transcriptional regulatory protein
H0S67_RS09060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H0S67_RS09090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0S67_RS09095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0S67_RS09100	COG0799	negative regulation of ribosome biogenesis
H0S67_RS09135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S67_RS09145	COG1555	photosystem II stabilization
H0S67_RS09160	COG0268	Binds directly to 16S ribosomal RNA
H0S67_RS09175	COG0028	Belongs to the TPP enzyme family
H0S67_RS09180	COG2755	lipolytic protein G-D-S-L family
H0S67_RS09180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H0S67_RS09185	COG0481	GTPase activity
H0S67_RS09195	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
H0S67_RS09230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S67_RS09235	COG1420	regulation of RNA biosynthetic process
H0S67_RS09240	COG0484	heat shock protein binding
H0S67_RS09260	COG0789	Transcriptional regulator
H0S67_RS09285	COG1595	DNA-templated transcription, initiation
H0S67_RS09290	COG0537	adenosine 5'-monophosphoramidase activity
H0S67_RS09315	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H0S67_RS09380	COG0110	maltose O-acetyltransferase activity
H0S67_RS09390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S67_RS09400	COG0596	Alpha beta hydrolase
H0S67_RS09405	COG1381	Involved in DNA repair and RecF pathway recombination
H0S67_RS09420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0S67_RS09440	COG1121	(ABC) transporter
H0S67_RS09520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS09625	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H0S67_RS09645	COG5002	protein histidine kinase activity
H0S67_RS09650	COG0318	PFAM AMP-dependent synthetase and ligase
H0S67_RS09715	COG2226	methyltransferase
H0S67_RS09735	COG0640	Transcriptional regulator
H0S67_RS09810	COG2197	response regulator
H0S67_RS09815	COG4585	Histidine kinase
H0S67_RS09825	COG1131	(ABC) transporter
H0S67_RS09830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H0S67_RS09835	COG2329	Antibiotic biosynthesis monooxygenase
H0S67_RS09865	COG0174	glutamine synthetase
H0S67_RS09875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0S67_RS09875	COG0512	Glutamine amidotransferase of anthranilate synthase
H0S67_RS09880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H0S67_RS09895	COG2172	sigma factor antagonist activity
H0S67_RS09905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H0S67_RS09930	COG0745	RESPONSE REGULATOR receiver
H0S67_RS09950	COG1752	Esterase of the alpha-beta hydrolase superfamily
H0S67_RS09980	COG1714	RDD family
H0S67_RS10000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H0S67_RS10005	COG1794	racemase activity, acting on amino acids and derivatives
H0S67_RS10030	COG1064	alcohol dehydrogenase
H0S67_RS10055	COG2197	response regulator
H0S67_RS10065	COG1252	NADH dehydrogenase
H0S67_RS10070	COG3387	PFAM Glycoside hydrolase 15-related
H0S67_RS10095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S67_RS10100	COG3119	arylsulfatase activity
H0S67_RS10130	COG2197	response regulator
H0S67_RS10135	COG4585	Histidine kinase
H0S67_RS10140	COG1131	(ABC) transporter
H0S67_RS10150	COG1597	lipid kinase activity
H0S67_RS10225	COG2909	trisaccharide binding
H0S67_RS10225	COG2909	trisaccharide binding
H0S67_RS10260	COG2235	arginine
H0S67_RS10265	COG1288	antiporter activity
H0S67_RS10275	COG0671	phosphoesterase, PA-phosphatase related
H0S67_RS10280	COG0628	permease
H0S67_RS10305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0S67_RS10410	COG1131	(ABC) transporter
H0S67_RS10460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0S67_RS10490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0S67_RS10515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0S67_RS10525	COG0330	HflC and HflK could
H0S67_RS10535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H0S67_RS10540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H0S67_RS10570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0S67_RS10585	COG3387	PFAM Glycoside hydrolase 15-related
H0S67_RS10590	COG5002	protein histidine kinase activity
H0S67_RS10590	COG3850	Histidine kinase
H0S67_RS10595	COG0745	RESPONSE REGULATOR receiver
H0S67_RS10600	COG1058	Belongs to the CinA family
H0S67_RS10600	COG1546	Belongs to the CinA family
H0S67_RS10610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0S67_RS10615	COG1201	RNA secondary structure unwinding
H0S67_RS10620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0S67_RS10630	COG0747	negative chemotaxis
H0S67_RS10635	COG0601	transmembrane transport
H0S67_RS10650	COG4608	Belongs to the ABC transporter superfamily
H0S67_RS10665	COG4638	Rieske (2fe-2S)
H0S67_RS10710	COG2409	Drug exporters of the RND superfamily
H0S67_RS10715	COG3858	chitin binding
H0S67_RS10730	COG1136	(ABC) transporter
H0S67_RS10740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0S67_RS10770	COG0183	Belongs to the thiolase family
H0S67_RS10785	COG2030	dehydratase
H0S67_RS10805	COG0515	serine threonine protein kinase
H0S67_RS10875	COG0556	nucleotide-excision repair
H0S67_RS10885	COG3180	Ammonia monooxygenase
H0S67_RS10920	COG0492	ferredoxin-NADP+ reductase activity
H0S67_RS10930	COG1309	transcriptional regulator
H0S67_RS10965	COG2326	polyphosphate kinase activity
H0S67_RS10980	COG2072	flavoprotein involved in K transport
H0S67_RS11030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S67_RS11035	COG1917	Cupin 2, conserved barrel domain protein
H0S67_RS11085	COG0667	Aldo Keto reductase
H0S67_RS11090	COG0740	serine-type endopeptidase activity
H0S67_RS11095	COG0740	serine-type endopeptidase activity
H0S67_RS11105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS11150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S67_RS11160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0S67_RS11180	COG1660	Displays ATPase and GTPase activities
H0S67_RS11190	COG1481	regulation of sporulation
H0S67_RS11195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0S67_RS11200	COG0126	phosphoglycerate kinase activity
H0S67_RS11205	COG0149	triose-phosphate isomerase activity
H0S67_RS11210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0S67_RS11225	COG0363	glucosamine-6-phosphate deaminase activity
H0S67_RS11235	COG0166	Belongs to the GPI family
H0S67_RS11240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0S67_RS11250	COG0109	protoheme IX farnesyltransferase activity
H0S67_RS11310	COG0396	ATPase activity
H0S67_RS11315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0S67_RS11320	COG0822	iron-sulfur transferase activity
H0S67_RS11325	COG2151	metal-sulfur cluster biosynthetic enzyme
H0S67_RS11330	COG2226	methyltransferase
H0S67_RS11340	COG1131	(ABC) transporter
H0S67_RS11345	COG3559	Exporter of polyketide antibiotics
H0S67_RS11370	COG1132	(ABC) transporter
H0S67_RS11400	COG3360	Dodecin
H0S67_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS11415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S67_RS11415	COG0189	ligase activity
H0S67_RS11425	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0S67_RS11425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S67_RS11495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H0S67_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS11545	COG1131	(ABC) transporter
H0S67_RS11595	COG1881	PFAM PEBP family protein
H0S67_RS11600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H0S67_RS11600	COG1648	precorrin-2 dehydrogenase activity
H0S67_RS11630	COG0242	peptide deformylase activity
H0S67_RS11635	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS11680	COG0516	GMP reductase activity
H0S67_RS11680	COG0517	IMP dehydrogenase activity
H0S67_RS11685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H0S67_RS11725	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS11765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S67_RS11775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H0S67_RS11790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0S67_RS11810	COG1968	undecaprenyl-diphosphatase activity
H0S67_RS11815	COG0598	Magnesium transport protein CorA
H0S67_RS11840	COG0215	cysteine-tRNA ligase activity
H0S67_RS11855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H0S67_RS11870	COG4585	Histidine kinase
H0S67_RS11875	COG2197	response regulator
H0S67_RS11885	COG1994	Peptidase M50
H0S67_RS11885	COG0517	IMP dehydrogenase activity
H0S67_RS11895	COG1222	aaa ATPase
H0S67_RS11915	COG2226	methyltransferase
H0S67_RS11920	COG4122	O-methyltransferase activity
H0S67_RS11930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H0S67_RS11935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H0S67_RS11945	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
H0S67_RS11950	COG0544	peptidyl-prolyl cis-trans isomerase activity
H0S67_RS11965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0S67_RS11970	COG0805	protein transport
H0S67_RS11990	COG0702	epimerase
H0S67_RS12020	COG0604	alcohol dehydrogenase
H0S67_RS12025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0S67_RS12030	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H0S67_RS12035	COG1607	acyl-coa hydrolase
H0S67_RS12050	COG3030	protein affecting phage T7 exclusion by the F plasmid
H0S67_RS12095	COG3158	transport of potassium into the cell
H0S67_RS12125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0S67_RS12130	COG4974	Belongs to the 'phage' integrase family
H0S67_RS12185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H0S67_RS12200	COG2130	NADP-dependent
H0S67_RS12220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0S67_RS12225	COG0420	3'-5' exonuclease activity
H0S67_RS12230	COG0419	ATPase involved in DNA repair
H0S67_RS12240	COG0419	ATPase involved in DNA repair
H0S67_RS12310	COG1716	ATPase activity
H0S67_RS12315	COG0509	glycine decarboxylation via glycine cleavage system
H0S67_RS12385	COG3118	belongs to the thioredoxin family
H0S67_RS12390	COG0542	response to heat
H0S67_RS12465	COG2826	transposase and inactivated derivatives, IS30 family
H0S67_RS12500	COG2826	transposase and inactivated derivatives, IS30 family
H0S67_RS12530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S67_RS12545	COG2197	response regulator
H0S67_RS12565	COG4124	Belongs to the glycosyl hydrolase 26 family
H0S67_RS12595	COG2217	Heavy metal translocating P-type atpase
H0S67_RS12610	COG0737	Belongs to the 5'-nucleotidase family
H0S67_RS12655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S67_RS12720	COG2197	response regulator
H0S67_RS12760	COG1160	GTP binding
H0S67_RS12770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0S67_RS12825	COG0494	nUDIX hydrolase
H0S67_RS12835	COG0504	CTP synthase activity
H0S67_RS12860	COG0497	DNA recombination
H0S67_RS12865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0S67_RS12880	COG0647	UMP catabolic process
H0S67_RS12910	COG2094	Belongs to the DNA glycosylase MPG family
H0S67_RS12915	COG0165	Argininosuccinate lyase
H0S67_RS12925	COG1051	belongs to the nudix hydrolase family
H0S67_RS12930	COG0137	argininosuccinate synthase activity
H0S67_RS12935	COG1438	arginine binding
H0S67_RS12940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0S67_RS12945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0S67_RS12950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0S67_RS12955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H0S67_RS12965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H0S67_RS12975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S67_RS12975	COG0072	phenylalanine-tRNA ligase activity
H0S67_RS12980	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0S67_RS12995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0S67_RS13000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0S67_RS13005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0S67_RS13025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H0S67_RS13030	COG1116	anion transmembrane transporter activity
H0S67_RS13035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H0S67_RS13045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS13065	COG2017	converts alpha-aldose to the beta-anomer
H0S67_RS13075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0S67_RS13080	COG0140	phosphoribosyl-ATP diphosphatase activity
H0S67_RS13085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0S67_RS13090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S67_RS13090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0S67_RS13140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0S67_RS13145	COG0242	peptide deformylase activity
H0S67_RS13155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0S67_RS13185	COG0284	orotidine-5'-phosphate decarboxylase activity
H0S67_RS13190	COG0167	dihydroorotate dehydrogenase activity
H0S67_RS13195	COG0543	2 iron, 2 sulfur cluster binding
H0S67_RS13230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0S67_RS13235	COG0540	Belongs to the ATCase OTCase family
H0S67_RS13240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H0S67_RS13245	COG3321	synthase
H0S67_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS13245	COG0604	alcohol dehydrogenase
H0S67_RS13290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0S67_RS13295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0S67_RS13305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0S67_RS13310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0S67_RS13315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0S67_RS13320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0S67_RS13335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H0S67_RS13345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0S67_RS13360	COG4608	Belongs to the ABC transporter superfamily
H0S67_RS13365	COG0444	Belongs to the ABC transporter superfamily
H0S67_RS13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0S67_RS13385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0S67_RS13410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H0S67_RS13415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0S67_RS13425	COG1862	Preprotein translocase
H0S67_RS13430	COG2255	four-way junction helicase activity
H0S67_RS13435	COG0632	four-way junction helicase activity
H0S67_RS13440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H0S67_RS13450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H0S67_RS13480	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H0S67_RS13485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H0S67_RS13500	COG0483	inositol monophosphate 1-phosphatase activity
H0S67_RS13600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S67_RS13605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S67_RS13610	COG0463	Glycosyl transferase, family 2
H0S67_RS13620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H0S67_RS13670	COG1301	dicarboxylic acid transport
H0S67_RS13695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H0S67_RS13700	COG0393	Putative heavy-metal-binding
H0S67_RS13740	COG2326	polyphosphate kinase activity
H0S67_RS13760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0S67_RS13765	COG5002	protein histidine kinase activity
H0S67_RS13785	COG2226	methyltransferase
H0S67_RS13805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0S67_RS13810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0S67_RS13815	COG2814	Major facilitator Superfamily
H0S67_RS13840	COG0842	Transport permease protein
H0S67_RS13845	COG1131	(ABC) transporter
H0S67_RS13865	COG0302	gtp cyclohydrolase
H0S67_RS13890	COG1595	DNA-templated transcription, initiation
H0S67_RS13910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H0S67_RS13920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H0S67_RS13925	COG0531	amino acid
H0S67_RS13930	COG0569	domain protein
H0S67_RS13955	COG0756	dUTP diphosphatase activity
H0S67_RS14010	COG2860	membrane
H0S67_RS14060	COG0477	Major facilitator Superfamily
H0S67_RS14105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H0S67_RS14115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H0S67_RS14120	COG3572	ergothioneine biosynthetic process
H0S67_RS14140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0S67_RS14165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0S67_RS14180	COG0589	response to stress
H0S67_RS14195	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H0S67_RS14200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H0S67_RS14210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S67_RS14235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H0S67_RS14250	COG0237	dephospho-CoA kinase activity
H0S67_RS14355	COG4981	capsule polysaccharide biosynthetic process
H0S67_RS14360	COG4981	capsule polysaccharide biosynthetic process
H0S67_RS14365	COG0500	methyltransferase
H0S67_RS14370	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS14435	COG0410	ABC transporter
H0S67_RS14455	COG0559	Belongs to the binding-protein-dependent transport system permease family
H0S67_RS14490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0S67_RS14500	COG0159	tryptophan synthase activity
H0S67_RS14505	COG0133	tryptophan synthase activity
H0S67_RS14510	COG0134	indole-3-glycerol-phosphate synthase activity
H0S67_RS14530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0S67_RS14540	COG1132	(ABC) transporter
H0S67_RS14565	COG0107	imidazoleglycerol-phosphate synthase activity
H0S67_RS14570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0S67_RS14580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0S67_RS14585	COG0131	Imidazoleglycerol-phosphate dehydratase
H0S67_RS14590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0S67_RS14595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0S67_RS14605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H0S67_RS14620	COG0587	DNA-directed DNA polymerase activity
H0S67_RS14640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S67_RS14655	COG1799	cell septum assembly
H0S67_RS14670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0S67_RS14680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0S67_RS14685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0S67_RS14695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0S67_RS14700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0S67_RS14705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0S67_RS14710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0S67_RS14725	COG0275	rRNA processing
H0S67_RS14730	COG2001	Belongs to the MraZ family
H0S67_RS14735	COG0714	Associated with various cellular activities
H0S67_RS14765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H0S67_RS14770	COG2226	methyltransferase
H0S67_RS14780	COG0587	DNA-directed DNA polymerase activity
H0S67_RS14785	COG0587	DNA-directed DNA polymerase activity
H0S67_RS14790	COG0587	DNA-directed DNA polymerase activity
H0S67_RS14830	COG1233	COG1233 Phytoene dehydrogenase and related
H0S67_RS14875	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H0S67_RS14900	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H0S67_RS14920	COG2197	response regulator
H0S67_RS14950	COG2197	response regulator
H0S67_RS14985	COG1940	carbohydrate kinase activity
H0S67_RS14990	COG1940	carbohydrate kinase activity
H0S67_RS15000	COG0003	Pfam Anion-transporting ATPase
H0S67_RS15010	COG1022	Amp-dependent synthetase and ligase
H0S67_RS15015	COG0501	Belongs to the peptidase M48B family
H0S67_RS15080	COG1845	cytochrome c oxidase, subunit III
H0S67_RS15090	COG0723	plastoquinol--plastocyanin reductase activity
H0S67_RS15095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H0S67_RS15100	COG1376	ErfK ybiS ycfS ynhG family protein
H0S67_RS15110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H0S67_RS15115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H0S67_RS15125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0S67_RS15125	COG0425	Belongs to the sulfur carrier protein TusA family
H0S67_RS15130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S67_RS15155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H0S67_RS15160	COG4251	negative regulation of phosphorylation
H0S67_RS15170	COG0501	Belongs to the peptidase M48B family
H0S67_RS15190	COG0667	Aldo Keto reductase
H0S67_RS15215	COG2213	PTS system mannitol-specific
H0S67_RS15215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S67_RS15220	COG1063	alcohol dehydrogenase
H0S67_RS15250	COG0612	Peptidase, M16
H0S67_RS15260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0S67_RS15270	COG0243	molybdopterin cofactor binding
H0S67_RS15280	COG1349	DNA-binding transcription factor activity
H0S67_RS15285	COG1105	Belongs to the carbohydrate kinase PfkB family
H0S67_RS15295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H0S67_RS15360	COG0442	prolyl-tRNA aminoacylation
H0S67_RS15405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H0S67_RS15410	COG0750	zinc metalloprotease
H0S67_RS15425	COG1177	transmembrane transport
H0S67_RS15430	COG1176	ABC-type spermidine putrescine transport system, permease component I
H0S67_RS15435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H0S67_RS15440	COG3842	ATPase activity
H0S67_RS15460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0S67_RS15465	COG1177	transmembrane transport
H0S67_RS15470	COG1176	ABC-type spermidine putrescine transport system, permease component I
H0S67_RS15475	COG3842	ATPase activity
H0S67_RS15505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S67_RS15530	COG2391	methyltransferase activity
H0S67_RS15550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H0S67_RS15570	COG0233	cytoplasmic translational termination
H0S67_RS15575	COG0528	UMP kinase activity
H0S67_RS15590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0S67_RS15595	COG0052	Belongs to the universal ribosomal protein uS2 family
H0S67_RS15605	COG4974	Belongs to the 'phage' integrase family
H0S67_RS15620	COG0792	nuclease activity
H0S67_RS15635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0S67_RS15645	COG0335	large ribosomal subunit rRNA binding
H0S67_RS15650	COG0336	Belongs to the RNA methyltransferase TrmD family
H0S67_RS15655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0S67_RS15660	COG1837	Belongs to the UPF0109 family
H0S67_RS15665	COG0228	four-way junction DNA binding
H0S67_RS15675	COG2197	response regulator
H0S67_RS15680	COG4585	Histidine kinase
H0S67_RS15705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S67_RS15710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H0S67_RS15785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H0S67_RS15790	COG0571	ribonuclease III activity
H0S67_RS15795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0S67_RS15805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0S67_RS15810	COG0742	ribosomal rna small subunit methyltransferase
H0S67_RS15820	COG1461	Dihydroxyacetone kinase
H0S67_RS15825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0S67_RS15845	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0S67_RS15855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H0S67_RS15865	COG1920	GTP binding
H0S67_RS15870	COG0776	regulation of translation
H0S67_RS15875	COG0066	3-isopropylmalate dehydratase activity
H0S67_RS15880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0S67_RS15890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0S67_RS15900	COG1316	TRANSCRIPTIONal
H0S67_RS15920	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H0S67_RS15920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0S67_RS15925	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0S67_RS15935	COG0739	heme binding
H0S67_RS15955	COG1268	BioY protein
H0S67_RS15960	COG1122	ATPase activity
H0S67_RS15965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H0S67_RS15975	COG0431	NADPH-dependent FMN reductase
H0S67_RS15990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0S67_RS16000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0S67_RS16005	COG0473	3-isopropylmalate dehydrogenase activity
H0S67_RS16020	COG2364	Membrane
H0S67_RS16035	COG0488	(ABC) transporter
H0S67_RS16065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S67_RS16070	COG0531	amino acid
H0S67_RS16075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0S67_RS16080	COG0440	acetolactate synthase activity
H0S67_RS16115	COG1289	transmembrane transporter activity
H0S67_RS16170	COG2133	pyrroloquinoline quinone binding
H0S67_RS16180	COG3845	ABC transporter
H0S67_RS16200	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0S67_RS16205	COG0154	amidase activity
H0S67_RS16270	COG0693	protein deglycase activity
H0S67_RS16280	COG0482	sulfurtransferase activity
H0S67_RS16305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H0S67_RS16310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0S67_RS16315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0S67_RS16320	COG1530	ribonuclease E activity
H0S67_RS16340	COG2807	transmembrane transport
H0S67_RS16380	COG0772	Belongs to the SEDS family
H0S67_RS16400	COG1077	Cell shape determining protein MreB Mrl
H0S67_RS16405	COG0105	UTP biosynthetic process
H0S67_RS16425	COG0285	dihydrofolate synthase activity
H0S67_RS16440	COG0525	valine-tRNA ligase activity
H0S67_RS16450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0S67_RS16455	COG0740	serine-type endopeptidase activity
H0S67_RS16460	COG0740	serine-type endopeptidase activity
H0S67_RS16495	COG0698	ribose 5-phosphate isomerase
H0S67_RS16515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0S67_RS16530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0S67_RS16555	COG0668	transmembrane transport
H0S67_RS16565	COG2346	COG2346, Truncated hemoglobins
H0S67_RS16585	COG0824	Thioesterase
H0S67_RS16615	COG0629	single-stranded DNA binding
H0S67_RS16635	COG0006	proline dipeptidase activity
H0S67_RS16640	COG1472	Belongs to the glycosyl hydrolase 3 family
H0S67_RS16645	COG2197	response regulator
H0S67_RS16665	COG0477	Major facilitator Superfamily
H0S67_RS16705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS16720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S67_RS16765	COG5002	protein histidine kinase activity
H0S67_RS16800	COG2890	protein-(glutamine-N5) methyltransferase activity
H0S67_RS16815	COG1295	ribonuclease BN
H0S67_RS16835	COG2366	antibiotic biosynthetic process
H0S67_RS16840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0S67_RS16865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0S67_RS16870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H0S67_RS16880	COG1131	(ABC) transporter
H0S67_RS16885	COG4585	Histidine kinase
H0S67_RS16890	COG2197	response regulator
H0S67_RS16900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0S67_RS16905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0S67_RS16935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0S67_RS16945	COG1335	isochorismatase
H0S67_RS16975	COG2814	Major facilitator Superfamily
H0S67_RS16980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H0S67_RS16985	COG1522	sequence-specific DNA binding
H0S67_RS16990	COG1414	Transcriptional regulator
H0S67_RS17005	COG1678	Uncharacterized ACR, COG1678
H0S67_RS17020	COG1470	cell adhesion involved in biofilm formation
H0S67_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS17060	COG3214	Protein conserved in bacteria
H0S67_RS17090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H0S67_RS17110	COG0745	RESPONSE REGULATOR receiver
H0S67_RS17115	COG2205	protein histidine kinase activity
H0S67_RS17120	COG2205	protein histidine kinase activity
H0S67_RS17140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0S67_RS17155	COG2884	Cell division ATP-binding protein ftsE
H0S67_RS17390	COG2409	Drug exporters of the RND superfamily
H0S67_RS17395	COG0477	Major facilitator Superfamily
H0S67_RS17470	COG2197	response regulator
H0S67_RS17480	COG2197	response regulator
H0S67_RS17485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0S67_RS17495	COG0745	RESPONSE REGULATOR receiver
H0S67_RS17515	COG1793	dna ligase
H0S67_RS17520	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H0S67_RS17525	COG4221	oxidoreductase activity
H0S67_RS17535	COG1132	(ABC) transporter
H0S67_RS17560	COG3483	tryptophan 2,3-dioxygenase activity
H0S67_RS17575	COG1902	pentaerythritol trinitrate reductase activity
H0S67_RS17625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S67_RS17635	COG1595	DNA-templated transcription, initiation
H0S67_RS17650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H0S67_RS17665	COG1024	Enoyl-CoA hydratase
H0S67_RS17690	COG1611	Belongs to the LOG family
H0S67_RS17705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0S67_RS17750	COG0017	Asparaginyl-tRNA synthetase
H0S67_RS17775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H0S67_RS17795	COG2149	membrane
H0S67_RS17800	COG1288	antiporter activity
H0S67_RS17805	COG2235	arginine
H0S67_RS17810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0S67_RS17815	COG0604	alcohol dehydrogenase
H0S67_RS17840	COG0515	serine threonine protein kinase
H0S67_RS17845	COG3300	MHYT domain
H0S67_RS17845	COG5001	Diguanylate cyclase
H0S67_RS17850	COG3447	MASE1 domain protein
H0S67_RS17850	COG5002	protein histidine kinase activity
H0S67_RS17850	COG5001	Diguanylate cyclase
H0S67_RS17855	COG5001	Diguanylate cyclase
H0S67_RS17860	COG5001	Diguanylate cyclase
H0S67_RS17860	COG3447	MASE1 domain protein
H0S67_RS17860	COG5002	protein histidine kinase activity
H0S67_RS17870	COG5001	Diguanylate cyclase
H0S67_RS17880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H0S67_RS17975	COG4969	Belongs to the N-Me-Phe pilin family
H0S67_RS17990	COG0739	heme binding
H0S67_RS17995	COG1191	sigma factor activity
H0S67_RS18060	COG0477	Major facilitator Superfamily
H0S67_RS18100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0S67_RS18110	COG0708	Exodeoxyribonuclease III
H0S67_RS18145	COG1322	Protein conserved in bacteria
H0S67_RS18155	COG0009	L-threonylcarbamoyladenylate synthase
H0S67_RS18175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0S67_RS18185	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H0S67_RS18190	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS18210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H0S67_RS18255	COG1473	amidohydrolase
H0S67_RS18255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H0S67_RS18300	COG0456	acetyltransferase
H0S67_RS18300	COG0454	-acetyltransferase
H0S67_RS18310	COG1053	succinate dehydrogenase
H0S67_RS18320	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS18330	COG1053	succinate dehydrogenase
H0S67_RS18335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0S67_RS18345	COG1295	ribonuclease BN
H0S67_RS18355	COG0180	Tryptophanyl-tRNA synthetase
H0S67_RS18360	COG0277	FAD linked oxidase domain protein
H0S67_RS18370	COG2814	Major facilitator Superfamily
H0S67_RS18380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0S67_RS18400	COG0039	L-malate dehydrogenase activity
H0S67_RS18410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0S67_RS18490	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H0S67_RS18500	COG2197	response regulator
H0S67_RS18525	COG0584	glycerophosphoryl diester phosphodiesterase
H0S67_RS18605	COG1132	(ABC) transporter
H0S67_RS18610	COG1132	(ABC) transporter
H0S67_RS18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS18620	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS18655	COG4214	carbohydrate transport
H0S67_RS18665	COG4213	ABC transporter substrate-binding protein
H0S67_RS18685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0S67_RS18685	COG0519	Catalyzes the synthesis of GMP from XMP
H0S67_RS18695	COG1012	belongs to the aldehyde dehydrogenase family
H0S67_RS18700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0S67_RS18710	COG0516	GMP reductase activity
H0S67_RS18730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0S67_RS18745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H0S67_RS18755	COG1595	DNA-templated transcription, initiation
H0S67_RS18765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H0S67_RS18770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0S67_RS18785	COG0456	acetyltransferase
H0S67_RS18785	COG1214	PFAM Peptidase M22, glycoprotease
H0S67_RS18790	COG0494	nUDIX hydrolase
H0S67_RS18805	COG0596	Alpha beta hydrolase
H0S67_RS18810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0S67_RS18825	COG0736	holo-[acyl-carrier-protein] synthase activity
H0S67_RS18830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S67_RS18835	COG1072	(Pantothenic acid kinase))
H0S67_RS18850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0S67_RS18855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0S67_RS18895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0S67_RS18900	COG0488	(ABC) transporter
H0S67_RS18970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0S67_RS18995	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS19015	COG3547	Transposase (IS116 IS110 IS902 family)
H0S67_RS19030	COG2208	phosphoserine phosphatase activity
H0S67_RS19030	COG2770	Histidine kinase
H0S67_RS19070	COG1595	DNA-templated transcription, initiation
H0S67_RS19080	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H0S67_RS19080	COG1672	PFAM Archaeal ATPase
H0S67_RS19085	COG2826	transposase and inactivated derivatives, IS30 family
H0S67_RS19100	COG0667	Aldo Keto reductase
H0S67_RS19105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0S67_RS19115	COG0640	Transcriptional regulator
H0S67_RS19125	COG2813	Specifically methylates the guanine in position
H0S67_RS19130	COG0101	tRNA pseudouridine synthase activity
H0S67_RS19140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H0S67_RS19150	COG0203	ribosomal protein L17
H0S67_RS19155	COG0202	RNA polymerase activity
H0S67_RS19160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0S67_RS19165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0S67_RS19170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0S67_RS19175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0S67_RS19180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0S67_RS19185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H0S67_RS19200	COG0563	adenylate kinase activity
H0S67_RS19210	COG0200	Binds to the 23S rRNA
H0S67_RS19215	COG1841	ribosomal large subunit assembly
H0S67_RS19220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0S67_RS19225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0S67_RS19230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0S67_RS19235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0S67_RS19240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0S67_RS19245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0S67_RS19250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0S67_RS19255	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0S67_RS19260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0S67_RS19265	COG0255	Belongs to the universal ribosomal protein uL29 family
H0S67_RS19270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0S67_RS19275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0S67_RS19280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0S67_RS19290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0S67_RS19295	COG0088	Forms part of the polypeptide exit tunnel
H0S67_RS19300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0S67_RS19305	COG0051	transcription antitermination factor activity, RNA binding
H0S67_RS19325	COG0714	Associated with various cellular activities
H0S67_RS19380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0S67_RS19390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H0S67_RS19395	COG0049	tRNA binding
H0S67_RS19400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0S67_RS19415	COG2252	PERMEase
H0S67_RS19435	COG1278	Cold shock
H0S67_RS19460	COG1595	DNA-templated transcription, initiation
H0S67_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS19540	COG0596	Alpha beta hydrolase
H0S67_RS19550	COG3973	AAA domain
H0S67_RS19575	COG2188	Transcriptional regulator
H0S67_RS19580	COG2177	Part of the ABC transporter FtsEX involved in
H0S67_RS19585	COG0577	efflux transmembrane transporter activity
H0S67_RS19585	COG1136	(ABC) transporter
H0S67_RS19600	COG2040	homocysteine
H0S67_RS19655	COG0542	response to heat
H0S67_RS19690	COG2826	transposase and inactivated derivatives, IS30 family
H0S67_RS19725	COG2755	lipolytic protein G-D-S-L family
H0S67_RS19730	COG3795	YCII-related domain
H0S67_RS19735	COG4941	Belongs to the sigma-70 factor family
H0S67_RS19740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H0S67_RS19775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H0S67_RS19795	COG0235	Class ii aldolase
H0S67_RS19800	COG3226	Transcriptional regulator
H0S67_RS19815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0S67_RS19835	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H0S67_RS19865	COG3958	Transketolase
H0S67_RS19870	COG3959	Transketolase, thiamine diphosphate binding domain
H0S67_RS19885	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS19900	COG0215	cysteine-tRNA ligase activity
H0S67_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
H0S67_RS19920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H0S67_RS19925	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H0S67_RS19940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H0S67_RS19940	COG2146	nitrite reductase [NAD(P)H] activity
H0S67_RS19955	COG2223	nitrite transmembrane transporter activity
H0S67_RS19970	COG1329	Transcriptional regulator
H0S67_RS19990	COG0588	phosphoglycerate mutase activity
H0S67_RS20000	COG5002	protein histidine kinase activity
H0S67_RS20005	COG0745	RESPONSE REGULATOR receiver
H0S67_RS20010	COG1404	Belongs to the peptidase S8 family
H0S67_RS20030	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS20045	COG1794	racemase activity, acting on amino acids and derivatives
H0S67_RS20130	COG2197	response regulator
H0S67_RS20165	COG1271	oxidase subunit
H0S67_RS20180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0S67_RS20270	COG0489	protein tyrosine kinase activity
H0S67_RS20300	COG2046	Belongs to the sulfate adenylyltransferase family
H0S67_RS20300	COG0529	Catalyzes the synthesis of activated sulfate
H0S67_RS20305	COG0730	response to heat
H0S67_RS20325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0S67_RS20330	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H0S67_RS20335	COG0297	glycogen (starch) synthase activity
H0S67_RS20345	COG0438	transferase activity, transferring glycosyl groups
H0S67_RS20375	COG4044	May play a role in the intracellular transport of hydrophobic ligands
H0S67_RS20395	COG3246	L-lysine catabolic process to acetate
H0S67_RS20405	COG1490	D-aminoacyl-tRNA deacylase activity
H0S67_RS20455	COG0745	RESPONSE REGULATOR receiver
H0S67_RS20460	COG0454	-acetyltransferase
H0S67_RS20460	COG0456	acetyltransferase
H0S67_RS20465	COG3119	arylsulfatase activity
H0S67_RS20480	COG1063	alcohol dehydrogenase
H0S67_RS20500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0S67_RS20510	COG0306	phosphate transporter
H0S67_RS20515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H0S67_RS20555	COG1937	Protein conserved in bacteria
H0S67_RS20565	COG1278	Cold shock
H0S67_RS20570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H0S67_RS20570	COG2755	lipolytic protein G-D-S-L family
H0S67_RS20595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0S67_RS20605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H0S67_RS20630	COG2351	hydroxyisourate hydrolase activity
H0S67_RS20795	COG1252	NADH dehydrogenase
H0S67_RS20805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S67_RS20810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H0S67_RS20905	COG1070	Carbohydrate kinase
H0S67_RS20920	COG2205	protein histidine kinase activity
H0S67_RS20920	COG0784	Response regulator, receiver
H0S67_RS20920	COG5002	protein histidine kinase activity
H0S67_RS20950	COG5002	protein histidine kinase activity
H0S67_RS20990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H0S67_RS21015	COG1309	transcriptional regulator
H0S67_RS21035	COG0047	phosphoribosylformylglycinamidine synthase activity
H0S67_RS21040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0S67_RS21055	COG2409	Drug exporters of the RND superfamily
H0S67_RS21060	COG2409	Drug exporters of the RND superfamily
H0S67_RS21085	COG1254	Belongs to the acylphosphatase family
H0S67_RS21095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0S67_RS21100	COG0151	Belongs to the GarS family
H0S67_RS21105	COG0753	catalase activity
H0S67_RS21110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0S67_RS21140	COG0191	fructose-bisphosphate aldolase activity
H0S67_RS21190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0S67_RS21205	COG0542	response to heat
H0S67_RS21225	COG1357	PFAM Pentapeptide repeats (8 copies)
H0S67_RS21235	COG0789	Transcriptional regulator
H0S67_RS21240	COG0484	heat shock protein binding
H0S67_RS21245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0S67_RS21250	COG0443	Heat shock 70 kDa protein
H0S67_RS21260	COG1846	Transcriptional regulator
H0S67_RS21265	COG0697	spore germination
H0S67_RS21295	COG2124	cytochrome p450
H0S67_RS21300	COG5002	protein histidine kinase activity
H0S67_RS21325	COG0577	efflux transmembrane transporter activity
H0S67_RS21340	COG4585	Histidine kinase
H0S67_RS21365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
H0S67_RS21365	COG1672	PFAM Archaeal ATPase
H0S67_RS21390	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
H0S67_RS21390	COG0778	Nitroreductase
H0S67_RS21395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0S67_RS21415	COG2301	Belongs to the HpcH HpaI aldolase family
H0S67_RS21420	COG2301	Belongs to the HpcH HpaI aldolase family
H0S67_RS21430	COG0501	Belongs to the peptidase M48B family
H0S67_RS21445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H0S67_RS21460	COG2271	Major facilitator Superfamily
H0S67_RS21485	COG0247	lactate metabolic process
H0S67_RS21485	COG2181	nitrate reductase activity
H0S67_RS21515	COG0717	Belongs to the dCTP deaminase family
H0S67_RS21520	COG2755	lipolytic protein G-D-S-L family
H0S67_RS21560	COG0730	response to heat
H0S67_RS21595	COG0300	oxidoreductase activity
H0S67_RS21605	COG1024	Enoyl-CoA hydratase
H0S67_RS21620	COG0390	transport system, permease component
H0S67_RS21630	COG1917	Cupin 2, conserved barrel domain protein
H0S67_RS21640	COG0584	glycerophosphoryl diester phosphodiesterase
H0S67_RS21670	COG4941	Belongs to the sigma-70 factor family
H0S67_RS21755	COG2188	Transcriptional regulator
H0S67_RS21765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H0S67_RS21770	COG2190	(PTS) system
H0S67_RS21810	COG2814	Major facilitator Superfamily
H0S67_RS21820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H0S67_RS21825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0S67_RS21840	COG0515	serine threonine protein kinase
H0S67_RS21845	COG1131	(ABC) transporter
H0S67_RS21855	COG1595	DNA-templated transcription, initiation
H0S67_RS21875	COG0778	Nitroreductase
H0S67_RS21885	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S67_RS21890	COG0022	dehydrogenase e1 component
H0S67_RS21905	COG2318	DinB family
H0S67_RS21975	COG1950	PFAM Membrane protein of
H0S67_RS22005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0S67_RS22010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0S67_RS22015	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S67_RS22015	COG0022	dehydrogenase e1 component
H0S67_RS22020	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0S67_RS22030	COG0596	Alpha beta hydrolase
H0S67_RS22035	COG0671	phosphoesterase, PA-phosphatase related
H0S67_RS22105	COG1595	DNA-templated transcription, initiation
H0S67_RS22110	COG1024	Enoyl-CoA hydratase
H0S67_RS22130	COG1595	DNA-templated transcription, initiation
H0S67_RS22145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0S67_RS22160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0S67_RS22165	COG2365	Tyrosine phosphatase family
H0S67_RS22185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H0S67_RS22235	COG1695	Transcriptional regulator
H0S67_RS22240	COG1714	RDD family
H0S67_RS22270	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS22285	COG0183	Belongs to the thiolase family
H0S67_RS22295	COG0400	carboxylic ester hydrolase activity
H0S67_RS22305	COG0702	epimerase
H0S67_RS22345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H0S67_RS22350	COG1126	abc transporter atp-binding protein
H0S67_RS22355	COG0765	amino acid transport
H0S67_RS22375	COG0446	pyridine nucleotide-disulphide oxidoreductase
H0S67_RS22375	COG1902	pentaerythritol trinitrate reductase activity
H0S67_RS22380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H0S67_RS22425	COG2909	trisaccharide binding
H0S67_RS22455	COG2755	lipolytic protein G-D-S-L family
H0S67_RS22465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0S67_RS22475	COG1960	acyl-CoA dehydrogenase activity
H0S67_RS22480	COG2353	YceI-like domain
H0S67_RS22485	COG0456	acetyltransferase
H0S67_RS22530	COG0339	signal peptide processing
H0S67_RS22565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H0S67_RS22605	COG3467	pyridoxamine 5'-phosphate
H0S67_RS22625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H0S67_RS22640	COG0189	ligase activity
H0S67_RS22640	COG0569	domain protein
H0S67_RS22645	COG0189	ligase activity
H0S67_RS22645	COG4067	protein conserved in archaea
H0S67_RS22710	COG0305	Participates in initiation and elongation during chromosome replication
H0S67_RS22725	COG0359	binds to the 23S rRNA
H0S67_RS22730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0S67_RS22735	COG0629	single-stranded DNA binding
H0S67_RS22740	COG0360	Binds together with S18 to 16S ribosomal RNA
H0S67_RS22795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H0S67_RS22820	COG0667	Aldo Keto reductase
H0S67_RS22835	COG0617	tRNA 3'-terminal CCA addition
H0S67_RS22865	COG1595	DNA-templated transcription, initiation
H0S67_RS22880	COG3118	belongs to the thioredoxin family
H0S67_RS22890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H0S67_RS22895	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0S67_RS22910	COG1192	Involved in chromosome partitioning
H0S67_RS22915	COG0357	Ribosomal RNA small subunit methyltransferase G
H0S67_RS22930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0S67_RS22935	COG0594	ribonuclease P activity
H0S67_RS22940	COG0230	Belongs to the bacterial ribosomal protein bL34 family