locus-tag	class	description
HCN53_RS00010	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HCN53_RS00035	ENOG4105CGD	Nad-dependent epimerase dehydratase
HCN53_RS00060	ENOG4105CP7	Triose-phosphate isomerase
HCN53_RS00065	ENOG4108XC3	NADH ubiquinone oxidoreductase
HCN53_RS00070	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HCN53_RS00075	ENOG410902K	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HCN53_RS00090	ENOG4105FE9	pseudouridine synthase
HCN53_RS00120	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HCN53_RS00130	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HCN53_RS00135	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HCN53_RS00140	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HCN53_RS00160	ENOG4105CN1	protease
HCN53_RS00180	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HCN53_RS00190	ENOG4105C5H	ABC transporter
HCN53_RS00200	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HCN53_RS00215	ENOG4105EN6	Membrane
HCN53_RS00245	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN53_RS00275	ENOG41080RH	Thioredoxin
HCN53_RS00280	ENOG4105D3R	alkyl hydroperoxide reductase
HCN53_RS00285	ENOG4105C1J	atp-dependent rna helicase
HCN53_RS00290	ENOG4105DFD	Na H antiporter
HCN53_RS00295	ENOG4105C3M	thioredoxin reductase
HCN53_RS00325	ENOG4107S8C	mandelate racemase muconate lactonizing
HCN53_RS00335	ENOG4105CEY	Amp-dependent synthetase and ligase
HCN53_RS00340	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HCN53_RS00360	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HCN53_RS00370	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HCN53_RS00375	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HCN53_RS00380	ENOG4108TZV	Membrane
HCN53_RS00390	ENOG4108MJ3	acetyltransferase
HCN53_RS00405	ENOG4105DA5	(ABC) transporter
HCN53_RS00420	ENOG4105C75	arginyL-tRNA synthetase
HCN53_RS00425	ENOG4105C1J	atp-dependent rna helicase
HCN53_RS00455	ENOG4105DJT	lAO AO transport system ATPase
HCN53_RS00470	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HCN53_RS00485	ENOG4108YYC	ycei family
HCN53_RS00505	ENOG4108J59	Extracellular solute-binding protein, family 5
HCN53_RS00530	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN53_RS00535	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HCN53_RS00540	ENOG4108IUX	(ABC) transporter
HCN53_RS00560	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN53_RS00565	ENOG4105CSR	polyphosphate kinase 2
HCN53_RS00570	ENOG4107QI1	Mate efflux family protein
HCN53_RS00600	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HCN53_RS00630	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HCN53_RS00640	ENOG41074B2	UPF0747 protein
HCN53_RS00645	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HCN53_RS00675	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HCN53_RS00680	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HCN53_RS00805	ENOG4105C59	p-type ATPase
HCN53_RS00825	ENOG4105E3B	Multicopper oxidase
HCN53_RS00840	ENOG4108IJF	Heavy metal efflux pump, CzcA
HCN53_RS00850	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN53_RS00860	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HCN53_RS00875	ENOG4105FJR	Lmbe family
HCN53_RS00880	ENOG4105C28	cystathionine
HCN53_RS00885	ENOG4105CI2	imidazolone-5-propionate hydrolase
HCN53_RS00895	ENOG4105CA0	peroxidase
HCN53_RS00910	ENOG4105VG0	50S ribosomal protein l34
HCN53_RS00915	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HCN53_RS00940	ENOG4105FQP	Beta-lactamase
HCN53_RS00975	ENOG4105CFH	Aspartokinase
HCN53_RS01000	ENOG4105CGY	Dna recombination protein
HCN53_RS01005	ENOG4105D3G	Pseudouridine synthase
HCN53_RS01010	ENOG4105BZ1	(ABC) transporter
HCN53_RS01020	ENOG4105CKK	Glycosyl transferase, family 2
HCN53_RS01030	ENOG41081WG	50s ribosomal protein l31
HCN53_RS01045	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HCN53_RS01100	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HCN53_RS01105	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HCN53_RS01110	ENOG4105CHR	reductase
HCN53_RS01125	ENOG4105CBC	glutamate synthase
HCN53_RS01155	ENOG4107QP3	malate synthase g
HCN53_RS01160	ENOG4107RET	Isocitrate lyase
HCN53_RS01175	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HCN53_RS01185	ENOG4108K8S	endonuclease I
HCN53_RS01205	ENOG4105C9A	Phoh family
HCN53_RS01230	ENOG4105C3G	gtp-binding protein
HCN53_RS01280	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HCN53_RS01295	ENOG4105DF5	DNA topoisomerase IV, subunit A
HCN53_RS01315	ENOG4105WMR	Protein CrcB homolog
HCN53_RS01325	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN53_RS01330	ENOG4105BZU	Histidine kinase
HCN53_RS01345	ENOG4105C1G	acyl-Coa dehydrogenase
HCN53_RS01350	ENOG4105CHU	acetyl-coa acetyltransferase
HCN53_RS01360	ENOG4105FS7	Transcriptional regulator
HCN53_RS01385	ENOG4105CJ1	ABC, transporter
HCN53_RS01425	ENOG4105CI2	imidazolone-5-propionate hydrolase
HCN53_RS01450	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HCN53_RS01460	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HCN53_RS01480	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HCN53_RS01520	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HCN53_RS01560	ENOG4105P8Q	Curli production assembly transport component CsgG
HCN53_RS01570	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
HCN53_RS01580	ENOG4105CZN	Potassium uptake protein
HCN53_RS01605	ENOG4105KWG	Pfam:DUF1696
HCN53_RS01655	ENOG4105C26	Dehydrogenase
HCN53_RS01690	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HCN53_RS01695	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HCN53_RS01730	ENOG4105DY9	regulatoR
HCN53_RS01755	ENOG4105CXT	aspartate transcarbamylase
HCN53_RS01760	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HCN53_RS01765	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HCN53_RS01800	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HCN53_RS01810	ENOG4105KME	endoribonuclease L-psp
HCN53_RS01820	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HCN53_RS01830	ENOG4105SFS	phosphoesterase RecJ domain protein
HCN53_RS01835	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HCN53_RS01845	ENOG4108Z03	MAF-like protein
HCN53_RS01865	ENOG4105CRE	cytochrome C
HCN53_RS01870	ENOG4108VX5	3-methyladenine DNA glycosylase
HCN53_RS01915	ENOG4105CRQ	synthase (Component I)
HCN53_RS01925	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HCN53_RS01935	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HCN53_RS01940	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HCN53_RS01945	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HCN53_RS01955	ENOG4107QQG	Dehydrogenase
HCN53_RS01965	ENOG4105C5E	polysaccharide biosynthesis protein
HCN53_RS01970	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HCN53_RS01975	ENOG4105F0R	Cytidylyltransferase
HCN53_RS01985	ENOG4108DRC	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HCN53_RS01990	ENOG4105D2T	synthase
HCN53_RS02020	ENOG4105D3Q	Sugar transferase
HCN53_RS02025	ENOG4105D7W	serine acetyltransferase
HCN53_RS02030	ENOG4105D3Q	Sugar transferase
HCN53_RS02035	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HCN53_RS02055	ENOG4107YJ4	chain length determinant protein
HCN53_RS02070	ENOG4105C8Y	Acetylornithine aminotransferase
HCN53_RS02090	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCN53_RS02095	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HCN53_RS02110	ENOG4105CNU	cell division protein FtsK
HCN53_RS02115	ENOG4107YR5	Diacylglycerol kinase
HCN53_RS02120	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HCN53_RS02135	ENOG4105C5Q	Transcriptional regulator
HCN53_RS02145	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HCN53_RS02160	ENOG4105K64	Glycosyl transferase, family 2
HCN53_RS02165	ENOG4105ER2	Ompa motb domain protein
HCN53_RS02175	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HCN53_RS02180	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HCN53_RS02190	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HCN53_RS02195	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HCN53_RS02205	ENOG4105CAT	Cytidine monophosphate kinase
HCN53_RS02225	ENOG4105KZX	Pterin carbinolamine dehydratase
HCN53_RS02255	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HCN53_RS02265	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HCN53_RS02280	ENOG4105CIN	aminoacyl-histidine dipeptidase
HCN53_RS02295	ENOG4107QM2	Aldo Keto reductase
HCN53_RS02305	ENOG4107Y03	Nitroreductase
HCN53_RS02320	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN53_RS02345	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN53_RS02365	ENOG4105DGW	oligopeptidase A
HCN53_RS02375	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HCN53_RS02380	ENOG4105E0X	reductase
HCN53_RS02385	ENOG4105E0X	reductase
HCN53_RS02395	ENOG4105E0A	ABC, transporter
HCN53_RS02400	ENOG4105EHG	Permease protein
HCN53_RS02425	ENOG4105D7N	magnesium and cobalt transport protein CorA
HCN53_RS02430	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HCN53_RS02445	ENOG4108JQ1	Dehydrogenase
HCN53_RS02450	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HCN53_RS02460	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HCN53_RS02470	ENOG4108IUZ	ABC transporter
HCN53_RS02485	ENOG4105CWX	Alpha-1,2-mannosidase
HCN53_RS02500	ENOG4105C9Q	fumarate hydratase class II
HCN53_RS02510	ENOG4105CDY	transcriptional regulatory protein
HCN53_RS02515	ENOG4108I7Y	domain protein
HCN53_RS02525	ENOG4107QKV	phosphomannomutase
HCN53_RS02540	ENOG4108IFH	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN53_RS02565	ENOG4108RMU	ferritin dps family protein
HCN53_RS02580	ENOG4105C3F	Signal peptidase i
HCN53_RS02585	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HCN53_RS02595	ENOG4105FA0	parb-like partition protein
HCN53_RS02600	ENOG4107QJE	Chromosome Partitioning Protein
HCN53_RS02620	ENOG4105DFA	alanine racemase domain protein
HCN53_RS02630	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS02640	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HCN53_RS02645	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HCN53_RS02650	ENOG4105VEQ	Cold shock protein
HCN53_RS02670	ENOG4107QWK	SAICAR synthetase
HCN53_RS02690	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HCN53_RS02705	ENOG4105C2F	Histidine kinase
HCN53_RS02740	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HCN53_RS02755	ENOG4107RNH	Outer membrane receptor FepA
HCN53_RS02760	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
HCN53_RS02770	ENOG4105UYK	outer membrane protein a
HCN53_RS02780	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN53_RS02785	ENOG4105BZU	Histidine kinase
HCN53_RS02800	ENOG4107MM9	BNR Asp-box repeat-containing protein
HCN53_RS02810	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HCN53_RS02815	ENOG4108IQE	Amp-dependent synthetase and ligase
HCN53_RS02845	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HCN53_RS02860	ENOG4105DEU	major facilitator superfamily
HCN53_RS02880	ENOG4108WQI	RNA Polymerase
HCN53_RS02885	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HCN53_RS02895	ENOG4106CKV	Pap2 superfamily protein
HCN53_RS02900	ENOG4105CPP	Dehydrogenase, E1 component
HCN53_RS02925	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HCN53_RS02930	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HCN53_RS02940	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HCN53_RS02945	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HCN53_RS02955	ENOG4105D5P	Methylmalonyl-coA mutase
HCN53_RS02970	ENOG4105KAF	membrAne
HCN53_RS02990	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HCN53_RS03010	ENOG4105D7Z	glutathione synthase
HCN53_RS03030	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HCN53_RS03040	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HCN53_RS03045	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HCN53_RS03055	ENOG4105CUT	histidyl-tRNA synthetase
HCN53_RS03075	ENOG4105F0I	Aminotransferase
HCN53_RS03080	ENOG4108UJU	UPF0301 protein
HCN53_RS03085	ENOG4105K70	DNA-binding protein
HCN53_RS03090	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HCN53_RS03095	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN53_RS03125	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
HCN53_RS03130	ENOG4105C98	muts2 protein
HCN53_RS03135	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HCN53_RS03140	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HCN53_RS03145	ENOG4107U9T	Pfam:Ribonuclease_BN
HCN53_RS03170	ENOG4105VN1	Heat shock protein
HCN53_RS03175	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HCN53_RS03180	ENOG4105DQ4	alcohol dehydrogenase
HCN53_RS03185	ENOG4105D0M	Protease HtpX homolog
HCN53_RS03190	ENOG4108RWN	rrna methyltransferase
HCN53_RS03195	ENOG4108S4H	thioesterase Superfamily protein
HCN53_RS03205	ENOG4105KPY	Small multidrug resistance protein
HCN53_RS03245	ENOG4105D5P	Methylmalonyl-coA mutase
HCN53_RS03260	ENOG4105DBI	uridine monophosphokinase
HCN53_RS03265	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HCN53_RS03275	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HCN53_RS03285	ENOG4105DF6	Fe-S oxidoreductase
HCN53_RS03290	ENOG4105DF6	Fe-S oxidoreductase
HCN53_RS03315	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HCN53_RS03320	ENOG4105CPK	Glycosyl transferase (Group 1
HCN53_RS03355	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HCN53_RS03360	ENOG4105I3K	Ferric uptake regulator, Fur family
HCN53_RS03365	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HCN53_RS03380	ENOG4105E2X	shikimate dehydrogenase
HCN53_RS03420	ENOG4105EJQ	L-serine dehydratase
HCN53_RS03425	ENOG4105CFG	Acts as a chaperone (By similarity)
HCN53_RS03435	ENOG4105DR9	pseudouridine synthase
HCN53_RS03440	ENOG4105C26	Dehydrogenase
HCN53_RS03455	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HCN53_RS03460	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN53_RS03535	ENOG4105NF4	modulator of drug activity
HCN53_RS03540	ENOG4105KVH	Transcriptional regulator
HCN53_RS03600	ENOG4105ED2	Beta-lactamase
HCN53_RS03610	ENOG4105EXC	Acyl-transferase
HCN53_RS03615	ENOG4105NF4	modulator of drug activity
HCN53_RS03620	ENOG4107653	Transcriptional regulator
HCN53_RS03645	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HCN53_RS03670	ENOG4105CKI	cobalamin synthesis protein
HCN53_RS03745	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN53_RS03760	ENOG41080WS	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HCN53_RS03770	ENOG4105D49	3-dehydroquinate synthase
HCN53_RS03785	ENOG4105EGS	Mechanosensitive ion channel
HCN53_RS03795	ENOG4105BZU	Histidine kinase
HCN53_RS03800	ENOG4105HHA	aminodeoxychorismate lyase
HCN53_RS03810	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HCN53_RS03815	ENOG4105C0H	protease
HCN53_RS03840	ENOG4105DU1	integral membrane protein, terc
HCN53_RS03855	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HCN53_RS03875	ENOG4105CHR	reductase
HCN53_RS03880	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HCN53_RS03890	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN53_RS03895	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HCN53_RS03905	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN53_RS03910	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN53_RS03915	ENOG4105DCI	Phosphohydrolase
HCN53_RS03920	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HCN53_RS03925	ENOG4108E87	P-loop hydrolase UPF0079
HCN53_RS03940	ENOG4105DCF	alanine dehydrogenase
HCN53_RS03950	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HCN53_RS03955	ENOG4105BZU	Histidine kinase
HCN53_RS03970	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HCN53_RS03995	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HCN53_RS04000	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HCN53_RS04005	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
HCN53_RS04010	ENOG4107Y7X	LytTR
HCN53_RS04015	ENOG4105C25	Primosomal protein n'
HCN53_RS04025	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HCN53_RS04030	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HCN53_RS04035	ENOG4108Z0Z	intracellular protease Pfpi family
HCN53_RS04040	ENOG4108VVK	transcriptional Regulator, AsnC
HCN53_RS04060	ENOG4105EE5	Membrane protein terC
HCN53_RS04065	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HCN53_RS04070	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HCN53_RS04080	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HCN53_RS04090	ENOG4105BZU	Histidine kinase
HCN53_RS04100	ENOG4105CD3	dihydroorotase
HCN53_RS04120	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HCN53_RS04130	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN53_RS04135	ENOG4105CSM	endonuclease III
HCN53_RS04170	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HCN53_RS04190	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HCN53_RS04200	ENOG4105C7H	Helicase, RecD TraA family
HCN53_RS04215	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HCN53_RS04225	ENOG4105C6E	dna polymerase iii
HCN53_RS04240	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HCN53_RS04250	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HCN53_RS04265	ENOG4105CTJ	Metal Dependent Phosphohydrolase
HCN53_RS04270	ENOG4105CHU	acetyl-coa acetyltransferase
HCN53_RS04285	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HCN53_RS04300	ENOG4105C84	Histidine ammonia-lyase
HCN53_RS04305	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HCN53_RS04310	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HCN53_RS04350	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HCN53_RS04360	ENOG4105CRQ	synthase (Component I)
HCN53_RS04365	ENOG4105KA0	thioesterase Superfamily protein
HCN53_RS04375	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HCN53_RS04385	ENOG4105IIU	Aminopeptidase
HCN53_RS04400	ENOG4105F0N	pyrophosphate phospho-hydrolase
HCN53_RS04405	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HCN53_RS04415	ENOG4105E9K	Isocitrate dehydrogenase
HCN53_RS04430	ENOG4105CDU	Replicative dna helicase
HCN53_RS04435	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HCN53_RS04450	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HCN53_RS04455	ENOG4108HHA	Transketolase
HCN53_RS04460	ENOG4108IUS	Transketolase
HCN53_RS04475	ENOG4105VEJ	Heat shock protein
HCN53_RS04490	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HCN53_RS04510	ENOG4105EWK	phytoene
HCN53_RS04520	ENOG4105IJY	hydroxylase
HCN53_RS04550	ENOG4108I0Z	Aconitate hydratase
HCN53_RS04555	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN53_RS04560	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HCN53_RS04570	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HCN53_RS04590	ENOG4105CQB	FAD linked oxidase domain protein
HCN53_RS04655	ENOG4108UT2	hemolysin iii
HCN53_RS04660	ENOG4105EA8	2-Nitropropane dioxygenase
HCN53_RS04665	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HCN53_RS04680	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN53_RS04685	ENOG4105C2X	Arabinose 5-phosphate isomerase
HCN53_RS04690	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HCN53_RS04705	ENOG4105CI3	gtp-binding protein typa
HCN53_RS04720	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HCN53_RS04730	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HCN53_RS04745	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN53_RS04755	ENOG4105C5X	domain protein
HCN53_RS04770	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HCN53_RS04795	ENOG4107RE3	peptidase, S41
HCN53_RS04840	ENOG4105C5H	ABC transporter
HCN53_RS04855	ENOG4105GPY	SprT protein
HCN53_RS04860	ENOG4108URH	decarboxylase
HCN53_RS04870	ENOG4105CPP	Dehydrogenase, E1 component
HCN53_RS04875	ENOG4105EYW	Ion transport protein
HCN53_RS04880	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HCN53_RS04895	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HCN53_RS04920	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HCN53_RS04925	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HCN53_RS04950	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HCN53_RS04960	ENOG4105CGH	5'-nucleotidase
HCN53_RS04965	ENOG4105CGH	5'-nucleotidase
HCN53_RS04975	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HCN53_RS04980	ENOG4105E2D	ec 3.2.1.52
HCN53_RS04990	ENOG4106N3A	copper homeostasis protein cutc
HCN53_RS05000	ENOG4105EGZ	biosynthesis protein
HCN53_RS05020	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HCN53_RS05030	ENOG4108Z5V	transcriptional regulator, merr family
HCN53_RS05055	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HCN53_RS05065	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HCN53_RS05070	ENOG4108IUZ	ABC transporter
HCN53_RS05130	ENOG4105C2I	pirin domain protein
HCN53_RS05155	ENOG4105C5H	ABC transporter
HCN53_RS05180	ENOG4105E6M	Sulphatase-modifying factor protein
HCN53_RS05195	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HCN53_RS05220	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HCN53_RS05225	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HCN53_RS05240	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HCN53_RS05260	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HCN53_RS05275	ENOG4108V0P	LemA family
HCN53_RS05310	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HCN53_RS05355	ENOG4105D4P	Coproporphyrinogen iii oxidase
HCN53_RS05360	ENOG4105DUM	transcriptional regulator, lysR family
HCN53_RS05380	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HCN53_RS05385	ENOG4105DXN	mazG family
HCN53_RS05395	ENOG4105N6Y	Thioredoxin
HCN53_RS05415	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HCN53_RS05430	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HCN53_RS05435	ENOG4105DWF	phosphomethylpyrimidine kinase
HCN53_RS05440	ENOG4105DWF	phosphomethylpyrimidine kinase
HCN53_RS05465	ENOG4108RCM	Nitroreductase
HCN53_RS05475	ENOG4105C5Q	Transcriptional regulator
HCN53_RS05480	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HCN53_RS05485	ENOG4105CNG	UPF0061 protein
HCN53_RS05490	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HCN53_RS05505	ENOG4107T9C	Alpha amylase catalytic region
HCN53_RS05520	ENOG4105E1F	short-chain dehydrogenase reductase
HCN53_RS05560	ENOG4105CTQ	phosphohexokinase
HCN53_RS05565	ENOG4105CK7	Sodium proline symporter
HCN53_RS05595	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HCN53_RS05605	ENOG4107QTF	adenylosuccinate lyase
HCN53_RS05610	ENOG4105VPI	YqaE family transport protein
HCN53_RS05640	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HCN53_RS05655	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HCN53_RS05665	ENOG4105C59	p-type ATPase
HCN53_RS05680	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HCN53_RS05685	ENOG4107YZX	Universal stress protein
HCN53_RS05695	ENOG4108YXA	Membrane
HCN53_RS05720	ENOG4108RCM	Nitroreductase
HCN53_RS05755	ENOG4108MN8	Membrane
HCN53_RS05760	ENOG4105EMN	RNA polymerase sigma factor
HCN53_RS05810	ENOG4105DHJ	ABC, transporter
HCN53_RS05840	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HCN53_RS05850	ENOG4105D2T	synthase
HCN53_RS05855	ENOG4105CUY	Mechanosensitive ion channel
HCN53_RS05860	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HCN53_RS05870	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HCN53_RS05900	ENOG4106WTF	Glycosyl transferase, family 2
HCN53_RS05905	ENOG4105K64	Glycosyl transferase, family 2
HCN53_RS05910	ENOG4105K64	Glycosyl transferase, family 2
HCN53_RS05915	ENOG4105K64	Glycosyl transferase, family 2
HCN53_RS05925	ENOG4105K64	Glycosyl transferase, family 2
HCN53_RS05930	ENOG4107T8Q	Glycosyl transferase (Group 1
HCN53_RS05955	ENOG4105EY8	ABC transporter
HCN53_RS05975	ENOG4105C5H	ABC transporter
HCN53_RS05985	ENOG4105C19	ABC transporter
HCN53_RS06000	ENOG41083ND	50S ribosomal protein L33
HCN53_RS06005	ENOG4105KDC	50s ribosomal protein l28
HCN53_RS06010	ENOG4105CEV	competence damage-inducible protein
HCN53_RS06015	ENOG4105ERH	Fumarylacetoacetate hydrolase
HCN53_RS06020	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HCN53_RS06045	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HCN53_RS06065	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HCN53_RS06070	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HCN53_RS06115	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HCN53_RS06130	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HCN53_RS06135	ENOG4105VPI	YqaE family transport protein
HCN53_RS06140	ENOG4105CRK	lysyL-tRNA synthetase
HCN53_RS06160	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HCN53_RS06180	ENOG4105CGP	Urocanate hydratase
HCN53_RS06190	ENOG4108UKZ	OsmC family
HCN53_RS06195	ENOG4105CPP	Dehydrogenase, E1 component
HCN53_RS06200	ENOG4105C7S	Dehydrogenase
HCN53_RS06210	ENOG4107QX3	carboxylase
HCN53_RS06215	ENOG4105CHH	sulfate transporter
HCN53_RS06235	ENOG4105CP2	von willebrand factor, type a
HCN53_RS06240	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HCN53_RS06245	ENOG4105VJV	50s ribosomal protein L35
HCN53_RS06250	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HCN53_RS06255	ENOG4105C22	threonyL-tRNA synthetase
HCN53_RS06275	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HCN53_RS06295	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HCN53_RS06300	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HCN53_RS06320	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS06330	ENOG4105DXM	phenylacetic acid degradation protein
HCN53_RS06345	ENOG4105CHU	acetyl-coa acetyltransferase
HCN53_RS06350	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS06375	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HCN53_RS06395	ENOG4105CGU	Enoyl-CoA hydratase
HCN53_RS06405	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
HCN53_RS06410	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
HCN53_RS06415	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
HCN53_RS06420	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
HCN53_RS06425	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HCN53_RS06445	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
HCN53_RS06455	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HCN53_RS06460	ENOG4107QN2	dihydrolipoyl dehydrogenase
HCN53_RS06490	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HCN53_RS06500	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN53_RS06510	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HCN53_RS06540	ENOG4105C3J	Cysteine desulfurase
HCN53_RS06590	ENOG4105C8Y	Acetylornithine aminotransferase
HCN53_RS06595	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HCN53_RS06620	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HCN53_RS06625	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HCN53_RS06630	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HCN53_RS06635	ENOG4105XA0	heptosyltransferase ii
HCN53_RS06645	ENOG4106WTF	Glycosyl transferase, family 2
HCN53_RS06660	ENOG4105E2K	Glycosyl transferase (Group 1
HCN53_RS06695	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HCN53_RS06715	ENOG4107R6T	Involved in the transcription termination process (By similarity)
HCN53_RS06720	ENOG4107RDP	Dehydrogenase
HCN53_RS06725	ENOG4105BZ1	(ABC) transporter
HCN53_RS06745	ENOG4108Z7R	Chaperone CsaA
HCN53_RS06760	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HCN53_RS06775	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HCN53_RS06795	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HCN53_RS06800	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HCN53_RS06805	ENOG4105D7A	ATP-binding protein
HCN53_RS06815	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HCN53_RS06830	ENOG4108N9J	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HCN53_RS06840	ENOG4105EFZ	amidohydrolase
HCN53_RS06855	ENOG4105CAK	Cell division ATP-binding protein ftsE
HCN53_RS06895	ENOG4105C7S	Dehydrogenase
HCN53_RS06905	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HCN53_RS06915	ENOG4105EEI	dihydropteroate synthase
HCN53_RS06935	ENOG4105BZ1	(ABC) transporter
HCN53_RS06940	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HCN53_RS06955	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HCN53_RS06985	ENOG4105CDV	Ompa motb domain protein
HCN53_RS07010	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
HCN53_RS07020	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HCN53_RS07040	ENOG4105EUJ	GTP cyclohydrolase i
HCN53_RS07045	ENOG4105C8N	cysteinyl-tRNA synthetase
HCN53_RS07050	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HCN53_RS07065	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN53_RS07105	ENOG4105DG6	mannose-6-phosphate isomerase
HCN53_RS07115	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HCN53_RS07125	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HCN53_RS07165	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HCN53_RS07215	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN53_RS07220	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN53_RS07225	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HCN53_RS07230	ENOG4107VNI	ribosomal protein l10
HCN53_RS07235	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HCN53_RS07240	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HCN53_RS07260	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HCN53_RS07285	ENOG4105MS2	ribosomal subunit Interface protein
HCN53_RS07290	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN53_RS07295	ENOG41083X6	30S ribosomal protein S21
HCN53_RS07300	ENOG4105C1G	acyl-Coa dehydrogenase
HCN53_RS07310	ENOG4105BZG	amino acid carrier protein
HCN53_RS07315	ENOG4107SVH	Potassium channel protein
HCN53_RS07340	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
HCN53_RS07350	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HCN53_RS07355	ENOG4105CJ2	(LipO)protein
HCN53_RS07370	ENOG4105II7	pyrroline-5-carboxylate reductase
HCN53_RS07380	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HCN53_RS07385	ENOG4105K63	Thioredoxin
HCN53_RS07405	ENOG4105DUX	Transporter
HCN53_RS07410	ENOG4105DUX	Transporter
HCN53_RS07420	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HCN53_RS07425	ENOG4107TT5	NLP P60 protein
HCN53_RS07430	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HCN53_RS07440	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HCN53_RS07445	ENOG4105CN1	protease
HCN53_RS07450	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HCN53_RS07495	ENOG4108IUK	alpha amylase, catalytic
HCN53_RS07505	ENOG4107URF	beta-phospho-glucomutase
HCN53_RS07520	ENOG4105C27	TonB-dependent Receptor Plug
HCN53_RS07545	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
HCN53_RS07550	ENOG4105C0B	DNA polymerase III (alpha subunit)
HCN53_RS07555	ENOG4105K63	Thioredoxin
HCN53_RS07565	ENOG4105C7S	Dehydrogenase
HCN53_RS07570	ENOG4108JYK	Dehydrogenase
HCN53_RS07575	ENOG4105KG3	cytidine deaminase
HCN53_RS07590	ENOG4105E6M	Sulphatase-modifying factor protein
HCN53_RS07595	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HCN53_RS07605	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HCN53_RS07630	ENOG4105C37	(CBS) domain
HCN53_RS07690	ENOG4105DFU	Cell wall formation (By similarity)
HCN53_RS07695	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HCN53_RS07700	ENOG4105DFF	Rod shape-determining protein mreb
HCN53_RS07710	ENOG4105CJN	penicillin-binding protein
HCN53_RS07715	ENOG4105CNI	cell division protein FtsW
HCN53_RS07730	ENOG4105FE9	pseudouridine synthase
HCN53_RS07745	ENOG4105CND	Glycosyl transferase, family 2
HCN53_RS07750	ENOG4105C3Q	Glycosyl transferase, family 2
HCN53_RS07760	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HCN53_RS07775	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HCN53_RS07785	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HCN53_RS07800	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HCN53_RS07805	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HCN53_RS07810	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HCN53_RS07820	ENOG4105CHM	Aminotransferase
HCN53_RS07825	ENOG4105CJ1	ABC, transporter
HCN53_RS07840	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HCN53_RS07855	ENOG4105CJW	magnesium transporter
HCN53_RS07860	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HCN53_RS07880	ENOG4105CN1	protease
HCN53_RS07890	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HCN53_RS07895	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
HCN53_RS07900	ENOG4105DJV	ribulose-phosphate 3-epimerase
HCN53_RS07910	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HCN53_RS07915	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HCN53_RS07940	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HCN53_RS07950	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HCN53_RS07955	ENOG4105C6K	Malic enzyme
HCN53_RS07960	ENOG4105D7K	pfkb domain protein
HCN53_RS07980	ENOG4105ETE	Transcriptional regulator (LacI family
HCN53_RS07990	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HCN53_RS07995	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HCN53_RS08000	ENOG4105Z4T	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HCN53_RS08025	ENOG4107SFQ	iron-sulfur binding
HCN53_RS08040	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HCN53_RS08045	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HCN53_RS08050	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HCN53_RS08055	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HCN53_RS08060	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HCN53_RS08090	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HCN53_RS08095	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HCN53_RS08110	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HCN53_RS08115	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HCN53_RS08145	ENOG4107XWI	flavin reductase domain protein, FMN-binding
HCN53_RS08155	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HCN53_RS08160	ENOG4108JQB	penicillin-binding protein 1C
HCN53_RS08175	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HCN53_RS08185	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HCN53_RS08215	ENOG4108Y6J	UPF0403 protein
HCN53_RS08220	ENOG4108HWS	Histidine kinase
HCN53_RS08235	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HCN53_RS08260	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCN53_RS08265	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HCN53_RS08275	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HCN53_RS08285	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HCN53_RS08290	ENOG4105EV9	Alpha Beta Hydrolase
HCN53_RS08305	ENOG41082T9	Membrane
HCN53_RS08310	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HCN53_RS08320	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HCN53_RS08325	ENOG4105GR3	Histidine kinase
HCN53_RS08335	ENOG4105E39	Enoyl-CoA hydratase
HCN53_RS08340	ENOG4107RBD	ABC, transporter
HCN53_RS08345	ENOG4107RPQ	ABC transporter
HCN53_RS08350	ENOG4105DIK	(ABC) transporter
HCN53_RS08355	ENOG4107SIG	periplasmic solute binding protein
HCN53_RS08365	ENOG4107RPQ	ABC transporter
HCN53_RS08375	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HCN53_RS08385	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HCN53_RS08390	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HCN53_RS08405	ENOG4105C28	cystathionine
HCN53_RS08415	ENOG4105DGU	Histone deacetylase
HCN53_RS08455	ENOG4108JQC	penicillin-binding protein 1A
HCN53_RS08460	ENOG410647Z	gliding motility-associated lipoprotein GldH
HCN53_RS08465	ENOG4105MA4	psp1 domain protein
HCN53_RS08480	ENOG4108KF3	Electron transport protein SCO1 SenC
HCN53_RS08505	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HCN53_RS08515	ENOG41083MR	nifu domain-containing protein
HCN53_RS08525	ENOG41072GX	Peptidase M22 Glycoprotease
HCN53_RS08530	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HCN53_RS08545	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN53_RS08550	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN53_RS08555	ENOG4105C19	ABC transporter
HCN53_RS08565	ENOG4108SJC	Membrane
HCN53_RS08595	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HCN53_RS08605	ENOG4105CHM	Aminotransferase
HCN53_RS08610	ENOG4105E33	succinate dehydrogenase
HCN53_RS08680	ENOG4105CSA	Coproporphyrinogen iii oxidase
HCN53_RS08735	ENOG4105ZMH	deoxynucleoside kinase
HCN53_RS08740	ENOG4105C31	Tryptophanyl-tRNA synthetase
HCN53_RS08745	ENOG4105CGK	Exodeoxyribonuclease III
HCN53_RS08750	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HCN53_RS08760	ENOG4105MJ2	Competence protein
HCN53_RS08780	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HCN53_RS08785	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HCN53_RS08795	ENOG4105C8T	Leucyl-tRNA synthetase
HCN53_RS08810	ENOG4105D44	asparaginase
HCN53_RS08815	ENOG4105C03	ribonuclease
HCN53_RS08820	ENOG4105K70	DNA-binding protein
HCN53_RS08830	ENOG4108UUM	single-stranded DNA-binding protein
HCN53_RS08835	ENOG4108JU5	Magnesium and cobalt efflux protein
HCN53_RS08865	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HCN53_RS08870	ENOG4105K46	50S ribosomal protein l27
HCN53_RS08880	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HCN53_RS08900	ENOG4107QVM	von Willebrand factor, type A
HCN53_RS08920	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HCN53_RS08925	ENOG4105C26	Dehydrogenase
HCN53_RS08935	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HCN53_RS08940	ENOG4108S4H	thioesterase Superfamily protein
HCN53_RS08965	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HCN53_RS08990	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HCN53_RS08995	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HCN53_RS09000	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HCN53_RS09040	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
HCN53_RS09050	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HCN53_RS09065	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HCN53_RS09075	ENOG4107RJ9	Cell division protein FtsX
HCN53_RS09080	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HCN53_RS09085	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HCN53_RS09090	ENOG4105DSJ	YicC domain protein
HCN53_RS09105	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HCN53_RS09115	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HCN53_RS09140	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HCN53_RS09145	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HCN53_RS09170	ENOG4107TAE	Glycosyl transferase (Group 1
HCN53_RS09180	ENOG4105C79	DNA protecting protein DprA
HCN53_RS09190	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HCN53_RS09225	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HCN53_RS09235	ENOG41068JE	domain protein
HCN53_RS09240	ENOG4105BZA	Phosphoglycerate kinase
HCN53_RS09245	ENOG4105FA2	dna polymerase iii
HCN53_RS09255	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HCN53_RS09260	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HCN53_RS09265	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HCN53_RS09275	ENOG4105EEF	Alkane 1-monooxygenase
HCN53_RS09280	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HCN53_RS09310	ENOG4105CX6	glutaminyL-tRNA synthetase
HCN53_RS09340	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HCN53_RS09345	ENOG4108YZG	isomerase
HCN53_RS09360	ENOG4107YB6	acetyltransferase, (GNAT) family
HCN53_RS09375	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HCN53_RS09385	ENOG4105UYK	outer membrane protein a
HCN53_RS09395	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HCN53_RS09405	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HCN53_RS09410	ENOG4107QP7	CoA-transferase subunit A
HCN53_RS09460	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HCN53_RS09470	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HCN53_RS09475	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HCN53_RS09480	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HCN53_RS09485	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HCN53_RS09520	ENOG4107QJZ	Glycosyl transferase, family 2
HCN53_RS09565	ENOG4105DY9	regulatoR
HCN53_RS09575	ENOG4105BZU	Histidine kinase
HCN53_RS09585	ENOG4105BZU	Histidine kinase
HCN53_RS09605	ENOG4108ZVT	methylmalonyl-coA epimerase
HCN53_RS09620	ENOG4105EMU	Dehydrogenase
HCN53_RS09625	ENOG410902V	Modulates RecA activity (By similarity)
HCN53_RS09645	ENOG4107T8J	thymidine kinase
HCN53_RS09650	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HCN53_RS09655	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HCN53_RS09660	ENOG4105D52	delta-aminolevulinic acid dehydratase
HCN53_RS09670	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HCN53_RS09680	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HCN53_RS09685	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HCN53_RS09700	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HCN53_RS09705	ENOG4107R73	Mate efflux family protein
HCN53_RS09745	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HCN53_RS09755	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HCN53_RS09785	ENOG4105C9B	Cysteine desulfurase
HCN53_RS09795	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HCN53_RS09800	ENOG4105VG1	fes assembly suf system protein
HCN53_RS09810	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HCN53_RS09815	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HCN53_RS09830	ENOG4105DN3	alpha-2-macroglobulin domain protein
HCN53_RS09840	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HCN53_RS09850	ENOG4105VMP	Transcriptional regulator
HCN53_RS09860	ENOG4105BZU	Histidine kinase
HCN53_RS09880	ENOG4105T7Q	H transporting two-sector ATPase delta epsilon subunit
HCN53_RS09885	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HCN53_RS09890	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HCN53_RS09905	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HCN53_RS09915	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HCN53_RS09925	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HCN53_RS09930	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HCN53_RS09935	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HCN53_RS09950	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HCN53_RS09955	ENOG4107ZT5	Thiol disulfide interchange protein
HCN53_RS09990	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HCN53_RS09995	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HCN53_RS10000	ENOG4105C8F	Beta-lactamase domain protein
HCN53_RS10015	ENOG4108R6K	riboflavin synthase, subunit alpha
HCN53_RS10020	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HCN53_RS10030	ENOG4105WXV	50S ribosomal protein L32
HCN53_RS10035	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HCN53_RS10040	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HCN53_RS10045	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HCN53_RS10055	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HCN53_RS10095	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HCN53_RS10100	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HCN53_RS10105	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HCN53_RS10110	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HCN53_RS10115	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HCN53_RS10125	ENOG4105CE1	Ferrous iron transport protein b
HCN53_RS10140	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HCN53_RS10145	ENOG4107QQR	Sporulation
HCN53_RS10150	ENOG4108HRK	Histidine kinase
HCN53_RS10170	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HCN53_RS10200	ENOG4105C0B	DNA polymerase III (alpha subunit)
HCN53_RS10205	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HCN53_RS10260	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HCN53_RS10270	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HCN53_RS10275	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HCN53_RS10290	ENOG4105C9M	aspartyl-trna synthetase
HCN53_RS10300	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HCN53_RS10330	ENOG4105C28	cystathionine
HCN53_RS10340	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HCN53_RS10345	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HCN53_RS10355	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HCN53_RS10365	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HCN53_RS10370	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HCN53_RS10385	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HCN53_RS10390	ENOG4107QRT	dEAD DEAH box helicase
HCN53_RS10405	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HCN53_RS10410	ENOG4105C7S	Dehydrogenase
HCN53_RS10415	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HCN53_RS10420	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HCN53_RS10450	ENOG4105C2M	dna polymerase I
HCN53_RS10480	ENOG4107YZX	Universal stress protein
HCN53_RS10485	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
HCN53_RS10490	ENOG4105CHV	Transcription elongation factor NusA
HCN53_RS10495	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HCN53_RS10500	ENOG4105EUB	pirin domain protein
HCN53_RS10505	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HCN53_RS10520	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HCN53_RS10525	ENOG41080R2	UPF0102 protein
HCN53_RS10555	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HCN53_RS10570	ENOG4108Z6B	deaminase
HCN53_RS10575	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HCN53_RS10610	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HCN53_RS10620	ENOG4105KBX	Transcriptional regulator, TetR family
HCN53_RS10630	ENOG4107T0X	DNA ligase
HCN53_RS10650	ENOG4105EXW	epimerase dehydratase
HCN53_RS10680	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCN53_RS10690	ENOG4105CFH	Aspartokinase
HCN53_RS10710	ENOG4108JQ1	Dehydrogenase
HCN53_RS10720	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HCN53_RS10735	ENOG4105CD3	dihydroorotase
HCN53_RS10740	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HCN53_RS10755	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HCN53_RS10760	ENOG4105M08	Membrane
HCN53_RS10780	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HCN53_RS10785	ENOG4105BZU	Histidine kinase
HCN53_RS10795	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HCN53_RS10825	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
HCN53_RS10830	ENOG4105D05	Receptor
HCN53_RS10850	ENOG4108JA2	transcriptioN-repair coupling factor
HCN53_RS10865	ENOG4108KPZ	tonB-dependent Receptor
HCN53_RS10870	ENOG4107QP8	phosphohexose isomerase
HCN53_RS10890	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HCN53_RS10905	ENOG4105D78	K07001 NTE family protein
HCN53_RS10910	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HCN53_RS10935	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HCN53_RS10965	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
HCN53_RS10970	ENOG4108U7W	acetyltransferase
HCN53_RS10990	ENOG4105C5S	asparaginyl-tRNA synthetase
HCN53_RS10995	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HCN53_RS11010	ENOG4109015	Biopolymer transport protein exbD tolR
HCN53_RS11045	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HCN53_RS11050	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HCN53_RS11055	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HCN53_RS11060	ENOG4105DTN	riboflavin biosynthesis protein ribF
HCN53_RS11070	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HCN53_RS11100	ENOG4105HDK	L-asparaginase
HCN53_RS11110	ENOG4105F8V	Hydrolase, tatD family
HCN53_RS11125	ENOG4105K5M	30s ribosomal protein S16
HCN53_RS11130	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HCN53_RS11135	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HCN53_RS11140	ENOG4105C1G	acyl-Coa dehydrogenase
HCN53_RS11155	ENOG41083MR	nifu domain-containing protein
HCN53_RS11160	ENOG4105D1F	ATP-binding protein
HCN53_RS11165	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HCN53_RS11170	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HCN53_RS11185	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HCN53_RS11190	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HCN53_RS11195	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN53_RS11210	ENOG4105EHZ	conserved protein UCP016719
HCN53_RS11215	ENOG4107RBB	ABC transporter, permease
HCN53_RS11250	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HCN53_RS11260	ENOG4105EUJ	GTP cyclohydrolase i
HCN53_RS11275	ENOG410667J	hydrolase
HCN53_RS11305	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HCN53_RS11310	ENOG4105C72	UPF0176 protein
HCN53_RS11320	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HCN53_RS11325	ENOG4105CE9	30S ribosomal protein S2
HCN53_RS11330	ENOG4108UJD	30S ribosomal protein S9
HCN53_RS11335	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HCN53_RS11350	ENOG4105E6M	Sulphatase-modifying factor protein
HCN53_RS11360	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HCN53_RS11380	ENOG4105C10	Electron transfer flavoprotein
HCN53_RS11415	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HCN53_RS11435	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
HCN53_RS11440	ENOG4105CAY	ferredoxin--nadp reductase
HCN53_RS11455	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HCN53_RS11505	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HCN53_RS11510	ENOG4105D2N	Aldolase
HCN53_RS11520	ENOG4108RWN	rrna methyltransferase
HCN53_RS11530	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HCN53_RS11535	ENOG4105C1A	potassium transporter peripheral membrane
HCN53_RS11540	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HCN53_RS11550	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HCN53_RS11575	ENOG4105NWN	ApaG protein
HCN53_RS11590	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN53_RS11595	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN53_RS11600	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN53_RS11605	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN53_RS11610	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HCN53_RS11625	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HCN53_RS11630	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HCN53_RS11640	ENOG4105C2C	drug resistance transporter, Bcr CflA
HCN53_RS11660	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HCN53_RS11665	ENOG4105BZU	Histidine kinase
HCN53_RS11720	ENOG4105CMR	udp-glucose 4-epimerase
HCN53_RS11725	ENOG4105C1G	acyl-Coa dehydrogenase
HCN53_RS11730	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HCN53_RS11740	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HCN53_RS11745	ENOG4105M8K	biopolymer transport protein
HCN53_RS11750	ENOG4109015	Biopolymer transport protein exbD tolR
HCN53_RS11760	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HCN53_RS11785	ENOG4108JJA	ABC, transporter
HCN53_RS11825	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HCN53_RS11865	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HCN53_RS11870	ENOG4108WQH	regulatoR
HCN53_RS11875	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HCN53_RS11890	ENOG4105VRT	cytoplasmic protein
HCN53_RS11895	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HCN53_RS11905	ENOG4107YM1	mraZ protein
HCN53_RS11910	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HCN53_RS11920	ENOG4105CJN	penicillin-binding protein
HCN53_RS11925	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HCN53_RS11930	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HCN53_RS11935	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HCN53_RS11940	ENOG4105CNI	cell division protein FtsW
HCN53_RS11945	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HCN53_RS11950	ENOG4105DFU	Cell wall formation (By similarity)
HCN53_RS11955	ENOG4108W8M	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity)
HCN53_RS11960	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HCN53_RS11965	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HCN53_RS11970	ENOG4105KTH	gatB Yqey
HCN53_RS11980	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HCN53_RS11995	ENOG4105C0D	helicase
HCN53_RS12040	ENOG41083J0	(ABC) transporter
HCN53_RS12095	ENOG4108VCT	Sulfite exporter TauE/SafE
HCN53_RS12100	ENOG4107TPS	domain protein
HCN53_RS12105	ENOG4105C2F	Histidine kinase
HCN53_RS12110	ENOG4108VAC	response regulator
HCN53_RS12130	ENOG4105KVH	Transcriptional regulator
HCN53_RS12135	ENOG4105EMU	Dehydrogenase
HCN53_RS12160	ENOG4105D6J	arsenicaL-resistance protein
HCN53_RS12180	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HCN53_RS12185	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HCN53_RS12205	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN53_RS12230	ENOG4105D05	Receptor
HCN53_RS12250	ENOG4105MIR	Phenylalanine 4-monooxygenase
HCN53_RS12285	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HCN53_RS12310	ENOG4105CHB	tonB-dependent Receptor
HCN53_RS12350	ENOG4105WH1	Two component transcriptional regulator luxr family
HCN53_RS12355	ENOG4105BZU	Histidine kinase
HCN53_RS12370	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HCN53_RS12395	ENOG4108IAB	Phoh family
HCN53_RS12400	ENOG4105ESI	atpase involved in dna repair
HCN53_RS12435	ENOG410836F	Transposase
HCN53_RS12480	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HCN53_RS12485	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HCN53_RS12490	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HCN53_RS12500	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HCN53_RS12505	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HCN53_RS12510	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HCN53_RS12515	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HCN53_RS12520	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HCN53_RS12525	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HCN53_RS12530	ENOG4105BZU	Histidine kinase
HCN53_RS12540	ENOG4107QN1	sodium solute
HCN53_RS12560	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HCN53_RS12565	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HCN53_RS12570	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HCN53_RS12575	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HCN53_RS12580	ENOG4107RI6	Anthranilate phosphoribosyltransferase
HCN53_RS12585	ENOG4105DDQ	anthranilate synthase
HCN53_RS12595	ENOG4105CRQ	synthase (Component I)
HCN53_RS12600	ENOG4105CAQ	asparagine synthetase
HCN53_RS12605	ENOG4107V8H	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HCN53_RS12615	ENOG4105EGD	dinuclear metal center protein, YbgI family
HCN53_RS12620	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HCN53_RS12625	ENOG4105BZU	Histidine kinase
HCN53_RS12635	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HCN53_RS12650	ENOG4107R0I	Cell wall formation (By similarity)
HCN53_RS12655	ENOG4105CHM	Aminotransferase
HCN53_RS12670	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HCN53_RS12680	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HCN53_RS12685	ENOG4105KNE	Phosphatidate cytidylyltransferase
HCN53_RS12695	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HCN53_RS12700	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HCN53_RS12715	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HCN53_RS12720	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HCN53_RS12735	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HCN53_RS12740	ENOG4105CPF	Cell wall formation (By similarity)
HCN53_RS12750	ENOG4105C34	Pseudouridine synthase
HCN53_RS12755	ENOG4105D1Q	UPF0246 protein
HCN53_RS12760	ENOG4105W5Q	DNA repair protein (RadC
HCN53_RS12775	ENOG4105D1H	recombination factor protein RarA
HCN53_RS12785	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HCN53_RS12810	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HCN53_RS12815	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HCN53_RS12820	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HCN53_RS12825	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HCN53_RS12830	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HCN53_RS12835	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HCN53_RS12840	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HCN53_RS12845	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN53_RS12850	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HCN53_RS12855	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HCN53_RS12860	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HCN53_RS12865	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HCN53_RS12870	ENOG41062E3	50S ribosomal protein L29
HCN53_RS12875	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HCN53_RS12880	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HCN53_RS12885	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HCN53_RS12890	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN53_RS12895	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HCN53_RS12900	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HCN53_RS12905	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HCN53_RS12910	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HCN53_RS12915	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HCN53_RS12920	ENOG41084HK	50S ribosomal protein L30
HCN53_RS12925	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HCN53_RS12930	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HCN53_RS12935	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HCN53_RS12940	ENOG410864M	50S ribosomal protein L36
HCN53_RS12945	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN53_RS12950	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HCN53_RS12955	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HCN53_RS12960	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HCN53_RS12965	ENOG4108ZT0	50S ribosomal protein l17
HCN53_RS12970	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HCN53_RS12975	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)