locus-tag	class	description
HCN53_RS00010	COG0148	phosphopyruvate hydratase activity
HCN53_RS00035	COG0702	epimerase
HCN53_RS00045	COG0116	Belongs to the methyltransferase superfamily
HCN53_RS00060	COG0149	triose-phosphate isomerase activity
HCN53_RS00065	COG3738	Protein conserved in bacteria
HCN53_RS00070	COG2264	protein methyltransferase activity
HCN53_RS00075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HCN53_RS00090	COG1187	pseudouridine synthase activity
HCN53_RS00115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN53_RS00120	COG0482	sulfurtransferase activity
HCN53_RS00130	COG0284	orotidine-5'-phosphate decarboxylase activity
HCN53_RS00135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCN53_RS00140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCN53_RS00160	COG0793	Belongs to the peptidase S41A family
HCN53_RS00180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCN53_RS00190	COG0488	(ABC) transporter
HCN53_RS00200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCN53_RS00245	COG0714	Associated with various cellular activities
HCN53_RS00250	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HCN53_RS00275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS00280	COG0450	alkyl hydroperoxide reductase
HCN53_RS00285	COG0513	Belongs to the DEAD box helicase family
HCN53_RS00295	COG0492	ferredoxin-NADP+ reductase activity
HCN53_RS00325	COG4948	Mandelate Racemase Muconate Lactonizing
HCN53_RS00335	COG0318	PFAM AMP-dependent synthetase and ligase
HCN53_RS00340	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HCN53_RS00355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN53_RS00360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCN53_RS00365	COG0824	Thioesterase
HCN53_RS00375	COG1739	Uncharacterized protein family UPF0029
HCN53_RS00380	COG0697	spore germination
HCN53_RS00385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN53_RS00385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN53_RS00390	COG0456	acetyltransferase
HCN53_RS00405	COG1131	(ABC) transporter
HCN53_RS00420	COG0018	arginyl-trna synthetase
HCN53_RS00425	COG0513	Belongs to the DEAD box helicase family
HCN53_RS00455	COG1703	isobutyryl-CoA mutase activity
HCN53_RS00470	COG0653	protein targeting
HCN53_RS00485	COG2353	YceI-like domain
HCN53_RS00505	COG4166	transmembrane transport
HCN53_RS00530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN53_RS00535	COG0484	heat shock protein binding
HCN53_RS00540	COG4152	abc transporter atp-binding protein
HCN53_RS00550	COG0668	transmembrane transport
HCN53_RS00560	COG2204	response regulator
HCN53_RS00565	COG2326	polyphosphate kinase activity
HCN53_RS00570	COG0534	Mate efflux family protein
HCN53_RS00600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCN53_RS00630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCN53_RS00640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HCN53_RS00645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCN53_RS00645	COG0519	Catalyzes the synthesis of GMP from XMP
HCN53_RS00675	COG0504	CTP synthase activity
HCN53_RS00680	COG0706	membrane insertase activity
HCN53_RS00720	COG3621	Patatin-like phospholipase
HCN53_RS00745	COG2217	Heavy metal translocating P-type atpase
HCN53_RS00805	COG2217	Heavy metal translocating P-type atpase
HCN53_RS00825	COG2132	Multicopper oxidase
HCN53_RS00840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCN53_RS00850	COG4974	Belongs to the 'phage' integrase family
HCN53_RS00860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN53_RS00875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCN53_RS00880	COG0626	cystathionine gamma-synthase activity
HCN53_RS00885	COG1228	amidohydrolase
HCN53_RS00895	COG1858	cytochrome C peroxidase
HCN53_RS00910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HCN53_RS00915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCN53_RS00975	COG0527	aspartate kinase activity
HCN53_RS01005	COG0564	pseudouridine synthase activity
HCN53_RS01010	COG1132	(ABC) transporter
HCN53_RS01015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN53_RS01020	COG0463	Glycosyl transferase, family 2
HCN53_RS01030	COG0254	rRNA binding
HCN53_RS01045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCN53_RS01100	COG0415	Belongs to the DNA photolyase family
HCN53_RS01105	COG0415	Belongs to the DNA photolyase family
HCN53_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
HCN53_RS01125	COG0069	glutamate synthase activity
HCN53_RS01155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCN53_RS01175	COG1234	tRNA 3'-trailer cleavage
HCN53_RS01185	COG2356	endonuclease I
HCN53_RS01205	COG1702	phosphate starvation-inducible protein PhoH
HCN53_RS01230	COG0012	GTP binding
HCN53_RS01315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCN53_RS01325	COG2197	response regulator
HCN53_RS01345	COG1960	acyl-CoA dehydrogenase activity
HCN53_RS01350	COG0183	Belongs to the thiolase family
HCN53_RS01355	COG1024	Enoyl-CoA hydratase
HCN53_RS01355	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS01360	COG1846	Transcriptional regulator
HCN53_RS01385	COG1131	(ABC) transporter
HCN53_RS01410	COG1612	heme a metabolic process
HCN53_RS01425	COG1228	amidohydrolase
HCN53_RS01450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCN53_RS01460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCN53_RS01480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCN53_RS01500	COG0628	permease
HCN53_RS01520	COG0326	Molecular chaperone. Has ATPase activity
HCN53_RS01560	COG1462	curli production assembly transport component CsgG
HCN53_RS01570	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCN53_RS01580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCN53_RS01590	COG1473	amidohydrolase
HCN53_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
HCN53_RS01690	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCN53_RS01695	COG1506	peptidase
HCN53_RS01695	COG0823	Involved in the tonB-independent uptake of proteins
HCN53_RS01725	COG2972	Histidine kinase
HCN53_RS01725	COG0745	RESPONSE REGULATOR receiver
HCN53_RS01730	COG3279	Response regulator of the LytR AlgR family
HCN53_RS01755	COG0540	Belongs to the ATCase OTCase family
HCN53_RS01785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN53_RS01785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCN53_RS01800	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCN53_RS01810	COG0251	oxidation-reduction process
HCN53_RS01820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN53_RS01830	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCN53_RS01835	COG0105	UTP biosynthetic process
HCN53_RS01845	COG0424	maF-like protein
HCN53_RS01865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCN53_RS01865	COG1333	cytochrome c biogenesis protein
HCN53_RS01870	COG2094	Belongs to the DNA glycosylase MPG family
HCN53_RS01915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN53_RS01925	COG4232	protein-disulfide reductase activity
HCN53_RS01935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCN53_RS01940	COG1088	dTDP-glucose 4,6-dehydratase activity
HCN53_RS01945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCN53_RS01955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCN53_RS01965	COG1086	Polysaccharide biosynthesis protein
HCN53_RS01970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN53_RS01975	COG1083	cytidylyl-transferase
HCN53_RS01985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN53_RS01985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN53_RS01990	COG2089	acid synthase
HCN53_RS02020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCN53_RS02025	COG1045	serine acetyltransferase
HCN53_RS02030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCN53_RS02035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN53_RS02055	COG0489	protein tyrosine kinase activity
HCN53_RS02070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN53_RS02090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCN53_RS02095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN53_RS02095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN53_RS02110	COG1674	ftsk spoiiie
HCN53_RS02115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCN53_RS02145	COG1575	Belongs to the MenA family. Type 1 subfamily
HCN53_RS02160	COG1216	Glycosyl transferase, family 2
HCN53_RS02165	COG1360	Flagellar Motor Protein
HCN53_RS02175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN53_RS02180	COG0335	large ribosomal subunit rRNA binding
HCN53_RS02190	COG0336	Belongs to the RNA methyltransferase TrmD family
HCN53_RS02195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN53_RS02205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCN53_RS02225	COG2154	pterin-4-alpha-carbinolamine dehydratase
HCN53_RS02255	COG0556	nucleotide-excision repair
HCN53_RS02280	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN53_RS02295	COG4989	oxidoreductase activity
HCN53_RS02300	COG0473	3-isopropylmalate dehydrogenase activity
HCN53_RS02305	COG0778	Nitroreductase
HCN53_RS02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN53_RS02345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN53_RS02345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN53_RS02360	COG1595	DNA-templated transcription, initiation
HCN53_RS02375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCN53_RS02380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN53_RS02385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN53_RS02400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN53_RS02425	COG0598	Magnesium transport protein CorA
HCN53_RS02430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN53_RS02445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN53_RS02450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCN53_RS02460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HCN53_RS02465	COG2267	carboxylic ester hydrolase activity
HCN53_RS02485	COG3537	Alpha-1,2-mannosidase
HCN53_RS02490	COG1446	asparaginase
HCN53_RS02510	COG0217	transcriptional regulatory protein
HCN53_RS02515	COG2823	Periplasmic or secreted lipoprotein
HCN53_RS02515	COG1652	LysM domain
HCN53_RS02525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN53_RS02540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS02565	COG0783	Belongs to the Dps family
HCN53_RS02580	COG0681	Belongs to the peptidase S26 family
HCN53_RS02585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCN53_RS02595	COG1475	DNA binding
HCN53_RS02600	COG1192	Involved in chromosome partitioning
HCN53_RS02630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS02640	COG0673	inositol 2-dehydrogenase activity
HCN53_RS02645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HCN53_RS02650	COG1278	Cold shock
HCN53_RS02670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCN53_RS02690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCN53_RS02705	COG2972	Histidine kinase
HCN53_RS02730	COG1073	alpha beta
HCN53_RS02740	COG4628	conserved protein (DUF2132)
HCN53_RS02760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HCN53_RS02775	COG2382	esterase
HCN53_RS02780	COG2197	response regulator
HCN53_RS02785	COG4585	Histidine kinase
HCN53_RS02800	COG3291	Pkd domain containing protein
HCN53_RS02805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN53_RS02810	COG2176	DNA-directed DNA polymerase activity
HCN53_RS02815	COG1022	Amp-dependent synthetase and ligase
HCN53_RS02845	COG0542	response to heat
HCN53_RS02860	COG2270	Major facilitator Superfamily
HCN53_RS02880	COG1595	DNA-templated transcription, initiation
HCN53_RS02885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCN53_RS02895	COG0671	phosphoesterase, PA-phosphatase related
HCN53_RS02900	COG0022	dehydrogenase e1 component
HCN53_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
HCN53_RS02930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN53_RS02940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN53_RS02945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN53_RS02955	COG1703	isobutyryl-CoA mutase activity
HCN53_RS02955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS02955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS02970	COG3152	Membrane
HCN53_RS02990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCN53_RS02995	COG1301	dicarboxylic acid transport
HCN53_RS03010	COG0189	ligase activity
HCN53_RS03030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCN53_RS03040	COG2824	Alkylphosphonate utilization operon protein PhnA
HCN53_RS03045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCN53_RS03055	COG0124	histidyl-tRNA synthetase
HCN53_RS03080	COG1678	Uncharacterized ACR, COG1678
HCN53_RS03090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN53_RS03095	COG0514	ATP-dependent DNA helicase (RecQ)
HCN53_RS03105	COG2921	Belongs to the UPF0250 family
HCN53_RS03115	COG3743	rRNA binding
HCN53_RS03115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN53_RS03125	COG3011	Protein conserved in bacteria
HCN53_RS03135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCN53_RS03145	COG1295	ribonuclease BN
HCN53_RS03170	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN53_RS03175	COG1902	pentaerythritol trinitrate reductase activity
HCN53_RS03180	COG1064	alcohol dehydrogenase
HCN53_RS03185	COG0501	Belongs to the peptidase M48B family
HCN53_RS03190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN53_RS03195	COG1607	acyl-coa hydrolase
HCN53_RS03205	COG2076	Multidrug Resistance protein
HCN53_RS03245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS03245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS03250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS03250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HCN53_RS03265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCN53_RS03275	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN53_RS03285	COG0247	lactate metabolic process
HCN53_RS03285	COG2181	nitrate reductase activity
HCN53_RS03290	COG0247	lactate metabolic process
HCN53_RS03290	COG2181	nitrate reductase activity
HCN53_RS03315	COG1472	Belongs to the glycosyl hydrolase 3 family
HCN53_RS03320	COG0438	transferase activity, transferring glycosyl groups
HCN53_RS03350	COG1363	Peptidase, m42
HCN53_RS03355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCN53_RS03360	COG0735	belongs to the Fur family
HCN53_RS03365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HCN53_RS03380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCN53_RS03420	COG1760	l-serine dehydratase
HCN53_RS03425	COG0443	Heat shock 70 kDa protein
HCN53_RS03435	COG0564	pseudouridine synthase activity
HCN53_RS03440	COG1012	belongs to the aldehyde dehydrogenase family
HCN53_RS03455	COG0009	L-threonylcarbamoyladenylate synthase
HCN53_RS03460	COG4974	Belongs to the 'phage' integrase family
HCN53_RS03535	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN53_RS03600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCN53_RS03615	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN53_RS03620	COG0583	DNA-binding transcription factor activity
HCN53_RS03645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCN53_RS03670	COG0523	cobalamin synthesis protein
HCN53_RS03745	COG0156	8-amino-7-oxononanoate synthase activity
HCN53_RS03760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HCN53_RS03770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCN53_RS03780	COG1231	oxidoreductase activity
HCN53_RS03785	COG1196	nuclear chromosome segregation
HCN53_RS03785	COG3264	Mechanosensitive ion channel
HCN53_RS03795	COG2202	Pas domain
HCN53_RS03795	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN53_RS03800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCN53_RS03810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCN53_RS03815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN53_RS03855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCN53_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
HCN53_RS03880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCN53_RS03890	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN53_RS03895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCN53_RS03905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN53_RS03905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HCN53_RS03910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN53_RS03915	COG1078	dGTPase activity
HCN53_RS03920	COG2204	response regulator
HCN53_RS03925	COG0802	atpase or kinase
HCN53_RS03940	COG0686	Belongs to the AlaDH PNT family
HCN53_RS03950	COG0045	succinate-CoA ligase (ADP-forming) activity
HCN53_RS03955	COG0004	ammonium transporteR
HCN53_RS03960	COG1187	pseudouridine synthase activity
HCN53_RS03970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCN53_RS03995	COG0359	binds to the 23S rRNA
HCN53_RS04000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCN53_RS04005	COG0360	Binds together with S18 to 16S ribosomal RNA
HCN53_RS04010	COG3279	Response regulator of the LytR AlgR family
HCN53_RS04015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCN53_RS04030	COG0592	DNA-directed DNA polymerase activity
HCN53_RS04035	COG0693	protein deglycase activity
HCN53_RS04040	COG1522	sequence-specific DNA binding
HCN53_RS04060	COG0861	Integral membrane protein TerC family
HCN53_RS04065	COG1970	mechanosensitive ion channel activity
HCN53_RS04070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN53_RS04080	COG1136	(ABC) transporter
HCN53_RS04100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN53_RS04120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCN53_RS04120	COG0321	lipoyl(octanoyl) transferase activity
HCN53_RS04130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN53_RS04135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCN53_RS04170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCN53_RS04190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HCN53_RS04200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCN53_RS04225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCN53_RS04240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCN53_RS04250	COG0259	pyridoxamine-phosphate oxidase activity
HCN53_RS04265	COG1480	7TM receptor with intracellular HD hydrolase
HCN53_RS04270	COG0183	Belongs to the thiolase family
HCN53_RS04285	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCN53_RS04290	COG0542	response to heat
HCN53_RS04300	COG2986	histidine ammonia-lyase
HCN53_RS04305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCN53_RS04305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HCN53_RS04310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCN53_RS04335	COG2133	pyrroloquinoline quinone binding
HCN53_RS04350	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCN53_RS04360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN53_RS04365	COG2050	protein possibly involved in aromatic compounds catabolism
HCN53_RS04375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCN53_RS04385	COG2234	aminopeptidase activity
HCN53_RS04405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN53_RS04430	COG0305	Participates in initiation and elongation during chromosome replication
HCN53_RS04435	COG0825	malonyl-CoA metabolic process
HCN53_RS04450	COG0343	queuine tRNA-ribosyltransferase activity
HCN53_RS04455	COG3959	Transketolase, thiamine diphosphate binding domain
HCN53_RS04460	COG3958	Transketolase
HCN53_RS04490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCN53_RS04510	COG1233	COG1233 Phytoene dehydrogenase and related
HCN53_RS04555	COG0714	Associated with various cellular activities
HCN53_RS04560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN53_RS04570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN53_RS04590	COG0277	FAD linked oxidase domain protein
HCN53_RS04600	COG2211	Major facilitator Superfamily
HCN53_RS04655	COG1272	protein, Hemolysin III
HCN53_RS04665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN53_RS04680	COG0514	ATP-dependent DNA helicase (RecQ)
HCN53_RS04685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCN53_RS04685	COG0517	IMP dehydrogenase activity
HCN53_RS04690	COG0805	protein transport
HCN53_RS04720	COG1047	Peptidyl-prolyl cis-trans
HCN53_RS04725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCN53_RS04730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCN53_RS04745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS04755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN53_RS04770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HCN53_RS04795	COG0793	Belongs to the peptidase S41A family
HCN53_RS04795	COG4946	Tricorn protease homolog
HCN53_RS04840	COG0488	(ABC) transporter
HCN53_RS04860	COG1611	Belongs to the LOG family
HCN53_RS04875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCN53_RS04880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCN53_RS04895	COG0237	dephospho-CoA kinase activity
HCN53_RS04920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCN53_RS04925	COG0497	DNA recombination
HCN53_RS04950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN53_RS04960	COG0737	Belongs to the 5'-nucleotidase family
HCN53_RS04965	COG0737	Belongs to the 5'-nucleotidase family
HCN53_RS04975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCN53_RS04980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HCN53_RS05000	COG2244	polysaccharide biosynthetic process
HCN53_RS05020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCN53_RS05030	COG4978	Transcriptional regulator
HCN53_RS05030	COG0789	Transcriptional regulator
HCN53_RS05050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCN53_RS05055	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HCN53_RS05065	COG1183	phosphatidylcholine synthase activity
HCN53_RS05070	COG1137	ATPase activity
HCN53_RS05080	COG0671	phosphoesterase, PA-phosphatase related
HCN53_RS05130	COG1741	Belongs to the pirin family
HCN53_RS05155	COG0488	(ABC) transporter
HCN53_RS05180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN53_RS05195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN53_RS05220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HCN53_RS05225	COG0459	protein refolding
HCN53_RS05240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN53_RS05260	COG2890	protein-(glutamine-N5) methyltransferase activity
HCN53_RS05275	COG1704	LemA family
HCN53_RS05330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCN53_RS05355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN53_RS05360	COG0583	DNA-binding transcription factor activity
HCN53_RS05380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN53_RS05385	COG3956	TIGRFAM MazG family protein
HCN53_RS05395	COG3118	belongs to the thioredoxin family
HCN53_RS05410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCN53_RS05415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCN53_RS05415	COG0047	phosphoribosylformylglycinamidine synthase activity
HCN53_RS05430	COG0352	thiamine-phosphate diphosphorylase activity
HCN53_RS05435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCN53_RS05435	COG0351	phosphomethylpyrimidine kinase
HCN53_RS05435	COG0352	thiamine-phosphate diphosphorylase activity
HCN53_RS05440	COG0351	phosphomethylpyrimidine kinase
HCN53_RS05440	COG0352	thiamine-phosphate diphosphorylase activity
HCN53_RS05480	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HCN53_RS05485	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HCN53_RS05505	COG0366	Alpha amylase catalytic
HCN53_RS05520	COG0300	oxidoreductase activity
HCN53_RS05560	COG0205	6-phosphofructokinase activity
HCN53_RS05565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN53_RS05595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCN53_RS05610	COG0401	homolog of Blt101
HCN53_RS05640	COG0348	domain, Protein
HCN53_RS05645	COG2010	Cytochrome c
HCN53_RS05655	COG3278	Belongs to the heme-copper respiratory oxidase family
HCN53_RS05665	COG2217	Heavy metal translocating P-type atpase
HCN53_RS05680	COG0259	pyridoxamine-phosphate oxidase activity
HCN53_RS05685	COG0589	response to stress
HCN53_RS05720	COG0778	Nitroreductase
HCN53_RS05725	COG1607	acyl-coa hydrolase
HCN53_RS05805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HCN53_RS05810	COG1127	ABC transporter
HCN53_RS05840	COG0297	glycogen (starch) synthase activity
HCN53_RS05850	COG2089	acid synthase
HCN53_RS05855	COG0668	transmembrane transport
HCN53_RS05860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HCN53_RS05870	COG1696	Membrane protein involved in D-alanine export
HCN53_RS05900	COG0463	Glycosyl transferase, family 2
HCN53_RS05905	COG1216	Glycosyl transferase, family 2
HCN53_RS05910	COG1216	Glycosyl transferase, family 2
HCN53_RS05915	COG1216	Glycosyl transferase, family 2
HCN53_RS05925	COG0463	Glycosyl transferase, family 2
HCN53_RS05950	COG2226	methyltransferase
HCN53_RS05975	COG0488	(ABC) transporter
HCN53_RS05985	COG1136	(ABC) transporter
HCN53_RS06000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCN53_RS06005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCN53_RS06010	COG1058	Belongs to the CinA family
HCN53_RS06010	COG1546	Belongs to the CinA family
HCN53_RS06015	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCN53_RS06020	COG0517	IMP dehydrogenase activity
HCN53_RS06020	COG0516	GMP reductase activity
HCN53_RS06045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCN53_RS06065	COG0415	Belongs to the DNA photolyase family
HCN53_RS06070	COG3046	protein related to deoxyribodipyrimidine photolyase
HCN53_RS06115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCN53_RS06130	COG0321	lipoyl(octanoyl) transferase activity
HCN53_RS06135	COG0401	homolog of Blt101
HCN53_RS06140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCN53_RS06160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCN53_RS06165	COG0791	NLP P60 protein
HCN53_RS06165	COG1388	LysM domain
HCN53_RS06180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCN53_RS06190	COG1765	OsmC-like protein
HCN53_RS06195	COG0022	dehydrogenase e1 component
HCN53_RS06200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN53_RS06210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCN53_RS06215	COG0659	secondary active sulfate transmembrane transporter activity
HCN53_RS06235	COG2304	oxidoreductase activity
HCN53_RS06240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCN53_RS06245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCN53_RS06250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCN53_RS06255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCN53_RS06275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN53_RS06280	COG4771	TonB-dependent receptor
HCN53_RS06295	COG0154	amidase activity
HCN53_RS06300	COG0552	protein localization to endoplasmic reticulum
HCN53_RS06320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS06320	COG1024	Enoyl-CoA hydratase
HCN53_RS06330	COG1012	belongs to the aldehyde dehydrogenase family
HCN53_RS06330	COG2030	dehydratase
HCN53_RS06345	COG0183	Belongs to the thiolase family
HCN53_RS06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN53_RS06375	COG4206	TonB-dependent receptor
HCN53_RS06395	COG1024	Enoyl-CoA hydratase
HCN53_RS06405	COG2151	metal-sulfur cluster biosynthetic enzyme
HCN53_RS06410	COG3396	Phenylacetate-CoA oxygenase
HCN53_RS06415	COG3460	Phenylacetate-CoA oxygenase
HCN53_RS06420	COG3396	Phenylacetate-CoA oxygenase
HCN53_RS06425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCN53_RS06445	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HCN53_RS06455	COG0167	dihydroorotate dehydrogenase activity
HCN53_RS06460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN53_RS06490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCN53_RS06500	COG4974	Belongs to the 'phage' integrase family
HCN53_RS06505	COG0656	L-ascorbic acid biosynthetic process
HCN53_RS06510	COG1418	mRNA catabolic process
HCN53_RS06540	COG1104	cysteine desulfurase activity
HCN53_RS06590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN53_RS06595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN53_RS06620	COG0242	peptide deformylase activity
HCN53_RS06625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCN53_RS06630	COG2171	N-acyltransferase activity
HCN53_RS06635	COG0859	PFAM glycosyl transferase family 9
HCN53_RS06645	COG0463	Glycosyl transferase, family 2
HCN53_RS06660	COG0438	transferase activity, transferring glycosyl groups
HCN53_RS06675	COG0517	IMP dehydrogenase activity
HCN53_RS06675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCN53_RS06675	COG0617	tRNA 3'-terminal CCA addition
HCN53_RS06695	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN53_RS06705	COG1862	Preprotein translocase
HCN53_RS06715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN53_RS06720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN53_RS06725	COG1132	(ABC) transporter
HCN53_RS06745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN53_RS06760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCN53_RS06775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN53_RS06795	COG0187	DNA topoisomerase II activity
HCN53_RS06800	COG0602	queuosine metabolic process
HCN53_RS06805	COG0433	COG0433 Predicted ATPase
HCN53_RS06815	COG0596	Alpha beta hydrolase
HCN53_RS06840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCN53_RS06855	COG2884	Cell division ATP-binding protein ftsE
HCN53_RS06895	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN53_RS06905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HCN53_RS06915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCN53_RS06935	COG1132	(ABC) transporter
HCN53_RS06940	COG0101	tRNA pseudouridine synthase activity
HCN53_RS07010	COG0268	Binds directly to 16S ribosomal RNA
HCN53_RS07020	COG0442	prolyl-tRNA aminoacylation
HCN53_RS07040	COG0302	gtp cyclohydrolase
HCN53_RS07045	COG0215	cysteine-tRNA ligase activity
HCN53_RS07050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCN53_RS07065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN53_RS07080	COG5658	integral membrane protein
HCN53_RS07105	COG1482	cell wall glycoprotein biosynthetic process
HCN53_RS07115	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HCN53_RS07125	COG2885	chlorophyll binding
HCN53_RS07160	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HCN53_RS07165	COG2885	chlorophyll binding
HCN53_RS07215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCN53_RS07220	COG0085	RNA polymerase activity
HCN53_RS07225	COG0222	ribosome binding
HCN53_RS07230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCN53_RS07235	COG0081	regulation of translation
HCN53_RS07240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCN53_RS07260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCN53_RS07285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCN53_RS07290	COG4974	Belongs to the 'phage' integrase family
HCN53_RS07295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCN53_RS07300	COG1960	acyl-CoA dehydrogenase activity
HCN53_RS07310	COG1115	amino acid carrier protein
HCN53_RS07315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCN53_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
HCN53_RS07350	COG2226	methyltransferase
HCN53_RS07355	COG1477	protein flavinylation
HCN53_RS07370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN53_RS07380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCN53_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS07405	COG3104	oligopeptide transport
HCN53_RS07410	COG3104	oligopeptide transport
HCN53_RS07420	COG0658	competence protein
HCN53_RS07420	COG2333	competence protein COMEC
HCN53_RS07425	COG0791	NLP P60 protein
HCN53_RS07430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN53_RS07440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HCN53_RS07445	COG0793	Belongs to the peptidase S41A family
HCN53_RS07450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN53_RS07495	COG0366	Alpha amylase catalytic
HCN53_RS07500	COG1554	hydrolase, family 65, central catalytic
HCN53_RS07505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCN53_RS07520	COG1629	transport
HCN53_RS07520	COG4206	TonB-dependent receptor
HCN53_RS07525	COG0702	epimerase
HCN53_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
HCN53_RS07555	COG3118	belongs to the thioredoxin family
HCN53_RS07565	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN53_RS07570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCN53_RS07575	COG0295	cytidine deaminase activity
HCN53_RS07590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN53_RS07595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCN53_RS07605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCN53_RS07630	COG1253	flavin adenine dinucleotide binding
HCN53_RS07645	COG1136	(ABC) transporter
HCN53_RS07645	COG0577	efflux transmembrane transporter activity
HCN53_RS07670	COG1876	peptidase activity
HCN53_RS07680	COG1629	transport
HCN53_RS07690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCN53_RS07690	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCN53_RS07695	COG0138	bifunctional purine biosynthesis protein purh
HCN53_RS07700	COG1077	Cell shape determining protein MreB Mrl
HCN53_RS07710	COG0768	penicillin binding
HCN53_RS07715	COG0772	Belongs to the SEDS family
HCN53_RS07730	COG1187	pseudouridine synthase activity
HCN53_RS07745	COG1215	transferase activity, transferring glycosyl groups
HCN53_RS07750	COG0463	Glycosyl transferase, family 2
HCN53_RS07760	COG1160	GTP binding
HCN53_RS07775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCN53_RS07785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCN53_RS07800	COG1490	D-aminoacyl-tRNA deacylase activity
HCN53_RS07805	COG1162	GTPase activity
HCN53_RS07810	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCN53_RS07820	COG0436	Aminotransferase
HCN53_RS07825	COG1131	(ABC) transporter
HCN53_RS07840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCN53_RS07855	COG2239	Acts as a magnesium transporter
HCN53_RS07860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCN53_RS07865	COG2205	protein histidine kinase activity
HCN53_RS07865	COG0784	Response regulator, receiver
HCN53_RS07880	COG0793	Belongs to the peptidase S41A family
HCN53_RS07890	COG2095	MarC family integral membrane protein
HCN53_RS07895	COG0492	ferredoxin-NADP+ reductase activity
HCN53_RS07900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCN53_RS07910	COG1185	polyribonucleotide nucleotidyltransferase activity
HCN53_RS07915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCN53_RS07940	COG0509	glycine decarboxylation via glycine cleavage system
HCN53_RS07950	COG0632	four-way junction helicase activity
HCN53_RS07955	COG0280	phosphate acetyltransferase
HCN53_RS07955	COG0281	malic enzyme
HCN53_RS07960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN53_RS07980	COG1609	Transcriptional regulator
HCN53_RS07990	COG2255	four-way junction helicase activity
HCN53_RS07995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCN53_RS08000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCN53_RS08025	COG0437	4 iron, 4 sulfur cluster binding
HCN53_RS08040	COG2885	chlorophyll binding
HCN53_RS08045	COG0156	8-amino-7-oxononanoate synthase activity
HCN53_RS08050	COG1074	ATP-dependent DNA helicase activity
HCN53_RS08055	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCN53_RS08080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HCN53_RS08080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HCN53_RS08090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCN53_RS08095	COG0519	Catalyzes the synthesis of GMP from XMP
HCN53_RS08110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HCN53_RS08115	COG2095	MarC family integral membrane protein
HCN53_RS08145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCN53_RS08155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCN53_RS08160	COG4953	penicillin-binding protein 1C
HCN53_RS08170	COG2954	triphosphatase activity
HCN53_RS08175	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HCN53_RS08185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCN53_RS08185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCN53_RS08220	COG5000	phosphorelay sensor kinase activity
HCN53_RS08235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCN53_RS08265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCN53_RS08275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCN53_RS08285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HCN53_RS08290	COG0596	Alpha beta hydrolase
HCN53_RS08305	COG1950	PFAM Membrane protein of
HCN53_RS08310	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCN53_RS08320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCN53_RS08325	COG5002	protein histidine kinase activity
HCN53_RS08335	COG1024	Enoyl-CoA hydratase
HCN53_RS08340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN53_RS08345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN53_RS08350	COG1121	(ABC) transporter
HCN53_RS08355	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCN53_RS08375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCN53_RS08385	COG0181	hydroxymethylbilane synthase activity
HCN53_RS08395	COG1253	flavin adenine dinucleotide binding
HCN53_RS08405	COG0626	cystathionine gamma-synthase activity
HCN53_RS08415	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCN53_RS08455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCN53_RS08465	COG1774	PSP1 C-terminal conserved region
HCN53_RS08480	COG1999	signal sequence binding
HCN53_RS08500	COG1428	Deoxynucleoside kinase
HCN53_RS08505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN53_RS08515	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCN53_RS08525	COG1214	PFAM Peptidase M22, glycoprotease
HCN53_RS08530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN53_RS08545	COG0577	efflux transmembrane transporter activity
HCN53_RS08545	COG1136	(ABC) transporter
HCN53_RS08550	COG1136	(ABC) transporter
HCN53_RS08550	COG0577	efflux transmembrane transporter activity
HCN53_RS08555	COG1136	(ABC) transporter
HCN53_RS08590	COG1845	cytochrome c oxidase, subunit III
HCN53_RS08595	COG0109	protoheme IX farnesyltransferase activity
HCN53_RS08605	COG0436	Aminotransferase
HCN53_RS08610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCN53_RS08615	COG1053	succinate dehydrogenase
HCN53_RS08630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN53_RS08655	COG4260	virion core protein, lumpy skin disease virus
HCN53_RS08680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN53_RS08735	COG1428	Deoxynucleoside kinase
HCN53_RS08740	COG0180	Tryptophanyl-tRNA synthetase
HCN53_RS08745	COG0708	Exodeoxyribonuclease III
HCN53_RS08750	COG0423	glycine-tRNA ligase activity
HCN53_RS08760	COG1040	competence protein
HCN53_RS08780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCN53_RS08785	COG0756	dUTP diphosphatase activity
HCN53_RS08795	COG0495	leucyl-tRNA aminoacylation
HCN53_RS08810	COG1446	asparaginase
HCN53_RS08815	COG1530	ribonuclease E activity
HCN53_RS08820	COG0776	regulation of translation
HCN53_RS08835	COG4535	Mg2 and Co2 transporter CorC
HCN53_RS08855	COG0612	Peptidase, M16
HCN53_RS08865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN53_RS08870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCN53_RS08880	COG0714	Associated with various cellular activities
HCN53_RS08900	COG2304	oxidoreductase activity
HCN53_RS08920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCN53_RS08925	COG1012	belongs to the aldehyde dehydrogenase family
HCN53_RS08935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCN53_RS08940	COG1607	acyl-coa hydrolase
HCN53_RS08965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCN53_RS08990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCN53_RS08995	COG1136	(ABC) transporter
HCN53_RS08995	COG0577	efflux transmembrane transporter activity
HCN53_RS09010	COG0006	proline dipeptidase activity
HCN53_RS09040	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HCN53_RS09050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HCN53_RS09065	COG1968	undecaprenyl-diphosphatase activity
HCN53_RS09075	COG2177	Part of the ABC transporter FtsEX involved in
HCN53_RS09080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCN53_RS09085	COG0194	GDP metabolic process
HCN53_RS09090	COG1561	YicC-like family, N-terminal region
HCN53_RS09105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCN53_RS09115	COG0408	coproporphyrinogen oxidase activity
HCN53_RS09145	COG1091	dTDP-4-dehydrorhamnose reductase activity
HCN53_RS09170	COG0438	transferase activity, transferring glycosyl groups
HCN53_RS09180	COG0758	DNA mediated transformation
HCN53_RS09190	COG2255	four-way junction helicase activity
HCN53_RS09220	COG1396	sequence-specific DNA binding
HCN53_RS09225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN53_RS09235	COG3942	CHAP domain
HCN53_RS09235	COG1388	LysM domain
HCN53_RS09240	COG0126	phosphoglycerate kinase activity
HCN53_RS09245	COG0470	DNA polymerase III
HCN53_RS09260	COG0445	tRNA wobble uridine modification
HCN53_RS09265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCN53_RS09280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN53_RS09310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN53_RS09340	COG0557	exoribonuclease II activity
HCN53_RS09345	COG0698	ribose 5-phosphate isomerase
HCN53_RS09360	COG2153	protein acetylation
HCN53_RS09375	COG0009	L-threonylcarbamoyladenylate synthase
HCN53_RS09390	COG0793	Belongs to the peptidase S41A family
HCN53_RS09390	COG3409	Peptidoglycan-binding domain 1 protein
HCN53_RS09395	COG0594	ribonuclease P activity
HCN53_RS09405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCN53_RS09410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCN53_RS09460	COG0356	it plays a direct role in the translocation of protons across the membrane
HCN53_RS09465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN53_RS09470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCN53_RS09475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN53_RS09480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCN53_RS09485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCN53_RS09565	COG3279	Response regulator of the LytR AlgR family
HCN53_RS09575	COG4251	negative regulation of phosphorylation
HCN53_RS09585	COG4251	negative regulation of phosphorylation
HCN53_RS09595	COG0784	Response regulator, receiver
HCN53_RS09605	COG0346	lactoylglutathione lyase activity
HCN53_RS09620	COG4221	oxidoreductase activity
HCN53_RS09625	COG2137	regulation of response to DNA damage stimulus
HCN53_RS09645	COG1435	thymidine kinase activity
HCN53_RS09650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCN53_RS09655	COG1970	mechanosensitive ion channel activity
HCN53_RS09660	COG0113	porphobilinogen synthase activity
HCN53_RS09665	COG0629	single-stranded DNA binding
HCN53_RS09670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCN53_RS09680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCN53_RS09685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCN53_RS09700	COG0720	synthase
HCN53_RS09705	COG0534	Mate efflux family protein
HCN53_RS09740	COG1309	transcriptional regulator
HCN53_RS09755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCN53_RS09765	COG0719	Fe-S assembly protein
HCN53_RS09775	COG0396	ATPase activity
HCN53_RS09780	COG0719	Fe-S assembly protein
HCN53_RS09785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCN53_RS09795	COG2166	iron-sulfur cluster assembly
HCN53_RS09800	COG2151	metal-sulfur cluster biosynthetic enzyme
HCN53_RS09815	COG0151	Belongs to the GarS family
HCN53_RS09830	COG2373	Large extracellular alpha-helical protein
HCN53_RS09840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCN53_RS09850	COG3655	Transcriptional regulator
HCN53_RS09860	COG4251	negative regulation of phosphorylation
HCN53_RS09865	COG0784	Response regulator, receiver
HCN53_RS09880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCN53_RS09885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCN53_RS09890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCN53_RS09900	COG1505	serine-type exopeptidase activity
HCN53_RS09905	COG3842	ATPase activity
HCN53_RS09915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCN53_RS09925	COG0297	glycogen (starch) synthase activity
HCN53_RS09930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCN53_RS09935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCN53_RS09950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCN53_RS09955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS09980	COG1215	transferase activity, transferring glycosyl groups
HCN53_RS09990	COG0481	GTPase activity
HCN53_RS09995	COG3263	regulation of cellular component size
HCN53_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN53_RS10020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HCN53_RS10030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCN53_RS10035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN53_RS10040	COG0511	ligase activity, forming carbon-carbon bonds
HCN53_RS10045	COG0439	Biotin carboxylase
HCN53_RS10055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCN53_RS10075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN53_RS10085	COG0469	pyruvate kinase activity
HCN53_RS10095	COG0571	ribonuclease III activity
HCN53_RS10100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN53_RS10105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN53_RS10110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCN53_RS10115	COG0328	RNA-DNA hybrid ribonuclease activity
HCN53_RS10140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCN53_RS10150	COG3275	phosphorelay sensor kinase activity
HCN53_RS10170	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCN53_RS10260	COG1519	Transferase
HCN53_RS10270	COG0402	S-adenosylhomocysteine deaminase activity
HCN53_RS10290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCN53_RS10300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HCN53_RS10330	COG0626	cystathionine gamma-synthase activity
HCN53_RS10340	COG0189	ligase activity
HCN53_RS10340	COG4067	protein conserved in archaea
HCN53_RS10345	COG0189	ligase activity
HCN53_RS10355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCN53_RS10365	COG2201	protein-glutamate methylesterase activity
HCN53_RS10370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCN53_RS10385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCN53_RS10390	COG1201	RNA secondary structure unwinding
HCN53_RS10405	COG0567	Dehydrogenase, E1 component
HCN53_RS10410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN53_RS10415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN53_RS10420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCN53_RS10450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN53_RS10450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN53_RS10455	COG1408	metallophosphoesterase
HCN53_RS10480	COG0589	response to stress
HCN53_RS10485	COG0779	Required for maturation of 30S ribosomal subunits
HCN53_RS10490	COG0195	Participates in both transcription termination and antitermination
HCN53_RS10495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCN53_RS10500	COG1741	Belongs to the pirin family
HCN53_RS10505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN53_RS10505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN53_RS10520	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCN53_RS10525	COG0792	nuclease activity
HCN53_RS10555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCN53_RS10575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCN53_RS10580	COG4447	cellulose binding
HCN53_RS10585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HCN53_RS10605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCN53_RS10610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN53_RS10620	COG1309	transcriptional regulator
HCN53_RS10630	COG1793	dna ligase
HCN53_RS10650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN53_RS10660	COG0784	Response regulator, receiver
HCN53_RS10660	COG2205	protein histidine kinase activity
HCN53_RS10680	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HCN53_RS10690	COG0527	aspartate kinase activity
HCN53_RS10710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN53_RS10720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCN53_RS10735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN53_RS10740	COG0463	Glycosyl transferase, family 2
HCN53_RS10755	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HCN53_RS10760	COG2363	Small membrane protein
HCN53_RS10780	COG0745	RESPONSE REGULATOR receiver
HCN53_RS10785	COG5002	protein histidine kinase activity
HCN53_RS10795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCN53_RS10825	COG1381	Involved in DNA repair and RecF pathway recombination
HCN53_RS10830	COG4771	TonB-dependent receptor
HCN53_RS10850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCN53_RS10870	COG0166	Belongs to the GPI family
HCN53_RS10890	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HCN53_RS10905	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCN53_RS10910	COG0322	excinuclease ABC activity
HCN53_RS10915	COG3118	belongs to the thioredoxin family
HCN53_RS10930	COG0671	phosphoesterase, PA-phosphatase related
HCN53_RS10935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN53_RS10965	COG3340	Belongs to the peptidase S51 family
HCN53_RS10970	COG0456	acetyltransferase
HCN53_RS10990	COG0017	Asparaginyl-tRNA synthetase
HCN53_RS10995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCN53_RS11010	COG0848	biopolymer transport protein
HCN53_RS11030	COG0811	peptide transport
HCN53_RS11045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCN53_RS11050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCN53_RS11055	COG0193	aminoacyl-tRNA hydrolase activity
HCN53_RS11060	COG0196	riboflavin kinase activity
HCN53_RS11070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCN53_RS11100	COG0252	asparaginase activity
HCN53_RS11110	COG0084	hydrolase, TatD family'
HCN53_RS11125	COG0228	four-way junction DNA binding
HCN53_RS11130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCN53_RS11135	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCN53_RS11140	COG1960	acyl-CoA dehydrogenase activity
HCN53_RS11155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCN53_RS11160	COG0489	protein tyrosine kinase activity
HCN53_RS11165	COG0233	cytoplasmic translational termination
HCN53_RS11170	COG0528	UMP kinase activity
HCN53_RS11185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCN53_RS11190	COG0563	adenylate kinase activity
HCN53_RS11195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN53_RS11210	COG3876	Protein conserved in bacteria
HCN53_RS11215	COG0577	efflux transmembrane transporter activity
HCN53_RS11250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN53_RS11260	COG0302	gtp cyclohydrolase
HCN53_RS11275	COG0561	phosphatase activity
HCN53_RS11305	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HCN53_RS11320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCN53_RS11325	COG0052	Belongs to the universal ribosomal protein uS2 family
HCN53_RS11330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCN53_RS11335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCN53_RS11350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN53_RS11360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCN53_RS11380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCN53_RS11390	COG0022	dehydrogenase e1 component
HCN53_RS11390	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN53_RS11415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HCN53_RS11425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCN53_RS11435	COG1959	2 iron, 2 sulfur cluster binding
HCN53_RS11440	COG0492	ferredoxin-NADP+ reductase activity
HCN53_RS11455	COG0101	tRNA pseudouridine synthase activity
HCN53_RS11460	COG1418	mRNA catabolic process
HCN53_RS11505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCN53_RS11510	COG0191	fructose-bisphosphate aldolase activity
HCN53_RS11520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN53_RS11530	COG2226	methyltransferase
HCN53_RS11535	COG0569	domain protein
HCN53_RS11545	COG0436	Aminotransferase
HCN53_RS11550	COG0357	Ribosomal RNA small subunit methyltransferase G
HCN53_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
HCN53_RS11575	COG2967	ApaG domain
HCN53_RS11590	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN53_RS11595	COG1805	sodium ion transport
HCN53_RS11605	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN53_RS11610	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HCN53_RS11625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCN53_RS11630	COG3844	kynureninase activity
HCN53_RS11640	COG2814	Major facilitator Superfamily
HCN53_RS11660	COG0745	RESPONSE REGULATOR receiver
HCN53_RS11665	COG3850	Histidine kinase
HCN53_RS11665	COG5002	protein histidine kinase activity
HCN53_RS11720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCN53_RS11725	COG1960	acyl-CoA dehydrogenase activity
HCN53_RS11730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HCN53_RS11740	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HCN53_RS11750	COG0848	biopolymer transport protein
HCN53_RS11760	COG0285	dihydrofolate synthase activity
HCN53_RS11785	COG2274	protein secretion by the type I secretion system
HCN53_RS11810	COG1476	TRANSCRIPTIONal
HCN53_RS11825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCN53_RS11840	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HCN53_RS11865	COG0358	DNA primase activity
HCN53_RS11870	COG2197	response regulator
HCN53_RS11875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCN53_RS11890	COG3530	Putative quorum-sensing-regulated virulence factor
HCN53_RS11895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCN53_RS11905	COG2001	Belongs to the MraZ family
HCN53_RS11910	COG0275	rRNA processing
HCN53_RS11920	COG0768	penicillin binding
HCN53_RS11925	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCN53_RS11930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN53_RS11935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCN53_RS11940	COG0772	Belongs to the SEDS family
HCN53_RS11945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN53_RS11950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCN53_RS11955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCN53_RS11965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCN53_RS11970	COG1610	YqeY-like protein
HCN53_RS11995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCN53_RS12000	COG1733	regulation of RNA biosynthetic process
HCN53_RS12040	COG4619	ABC transporter
HCN53_RS12095	COG0730	response to heat
HCN53_RS12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN53_RS12100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN53_RS12105	COG2972	Histidine kinase
HCN53_RS12110	COG3279	Response regulator of the LytR AlgR family
HCN53_RS12130	COG1733	regulation of RNA biosynthetic process
HCN53_RS12135	COG4221	oxidoreductase activity
HCN53_RS12160	COG0798	PFAM Bile acid sodium symporter
HCN53_RS12180	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN53_RS12205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN53_RS12230	COG4771	TonB-dependent receptor
HCN53_RS12250	COG3186	Phenylalanine-4-hydroxylase
HCN53_RS12285	COG1166	arginine decarboxylase activity
HCN53_RS12290	COG0010	Belongs to the arginase family
HCN53_RS12310	COG4772	TonB-dependent receptor
HCN53_RS12350	COG2197	response regulator
HCN53_RS12355	COG4585	Histidine kinase
HCN53_RS12370	COG0514	ATP-dependent DNA helicase (RecQ)
HCN53_RS12395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCN53_RS12400	COG1196	nuclear chromosome segregation
HCN53_RS12435	COG3547	Transposase (IS116 IS110 IS902 family)
HCN53_RS12480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCN53_RS12480	COG0140	phosphoribosyl-ATP diphosphatase activity
HCN53_RS12485	COG0107	imidazoleglycerol-phosphate synthase activity
HCN53_RS12490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCN53_RS12500	COG0131	Imidazoleglycerol-phosphate dehydratase
HCN53_RS12505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCN53_RS12510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCN53_RS12515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCN53_RS12520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCN53_RS12525	COG0745	RESPONSE REGULATOR receiver
HCN53_RS12530	COG5002	protein histidine kinase activity
HCN53_RS12540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN53_RS12560	COG0159	tryptophan synthase activity
HCN53_RS12565	COG0133	tryptophan synthase activity
HCN53_RS12570	COG0135	phosphoribosylanthranilate isomerase activity
HCN53_RS12575	COG0134	indole-3-glycerol-phosphate synthase activity
HCN53_RS12580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCN53_RS12585	COG0512	Glutamine amidotransferase of anthranilate synthase
HCN53_RS12595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN53_RS12600	COG0367	asparagine synthase
HCN53_RS12605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN53_RS12615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCN53_RS12620	COG1663	tetraacyldisaccharide 4'-kinase activity
HCN53_RS12625	COG3437	response regulator, receiver
HCN53_RS12625	COG2205	protein histidine kinase activity
HCN53_RS12625	COG4999	Histidine kinase
HCN53_RS12625	COG3850	Histidine kinase
HCN53_RS12635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCN53_RS12640	COG1215	transferase activity, transferring glycosyl groups
HCN53_RS12650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCN53_RS12655	COG0436	Aminotransferase
HCN53_RS12670	COG0525	valine-tRNA ligase activity
HCN53_RS12680	COG0688	phosphatidylethanolamine metabolic process
HCN53_RS12685	COG4589	Belongs to the CDS family
HCN53_RS12695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN53_RS12700	COG0799	negative regulation of ribosome biogenesis
HCN53_RS12715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCN53_RS12720	COG1051	belongs to the nudix hydrolase family
HCN53_RS12735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCN53_RS12740	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCN53_RS12750	COG0564	pseudouridine synthase activity
HCN53_RS12755	COG3022	response to hydroperoxide
HCN53_RS12760	COG2003	Belongs to the UPF0758 family
HCN53_RS12770	COG1011	Hydrolase
HCN53_RS12775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCN53_RS12785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN53_RS12800	COG4771	TonB-dependent receptor
HCN53_RS12810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCN53_RS12815	COG0049	tRNA binding
HCN53_RS12820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCN53_RS12825	COG0051	transcription antitermination factor activity, RNA binding
HCN53_RS12830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCN53_RS12835	COG0088	Forms part of the polypeptide exit tunnel
HCN53_RS12840	COG0089	rRNA binding
HCN53_RS12845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN53_RS12850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HCN53_RS12855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HCN53_RS12860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCN53_RS12865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCN53_RS12870	COG0255	Belongs to the universal ribosomal protein uL29 family
HCN53_RS12875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCN53_RS12880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCN53_RS12885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HCN53_RS12890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN53_RS12895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCN53_RS12900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCN53_RS12905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCN53_RS12910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCN53_RS12915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCN53_RS12920	COG1841	ribosomal large subunit assembly
HCN53_RS12925	COG0200	Binds to the 23S rRNA
HCN53_RS12935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HCN53_RS12940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCN53_RS12945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN53_RS12950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCN53_RS12955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCN53_RS12960	COG0202	RNA polymerase activity
HCN53_RS12965	COG0203	ribosomal protein L17
HCN53_RS12970	COG0505	Belongs to the CarA family
HCN53_RS12975	COG0148	phosphopyruvate hydratase activity