locus-tag	class	description
GKE62_RS00010	COG0181	hydroxymethylbilane synthase activity
GKE62_RS00050	COG0556	nucleotide-excision repair
GKE62_RS00080	COG1305	Transglutaminase-like
GKE62_RS00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GKE62_RS00110	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GKE62_RS00120	COG0137	argininosuccinate synthase activity
GKE62_RS00130	COG0657	acetylesterase activity
GKE62_RS00140	COG0492	ferredoxin-NADP+ reductase activity
GKE62_RS00195	COG3409	Peptidoglycan-binding domain 1 protein
GKE62_RS00195	COG3267	Type II secretory pathway component ExeA
GKE62_RS00220	COG0367	asparagine synthase
GKE62_RS00225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKE62_RS00230	COG1131	(ABC) transporter
GKE62_RS00235	COG0842	Transport permease protein
GKE62_RS00240	COG0842	Transport permease protein
GKE62_RS00245	COG1024	Enoyl-CoA hydratase
GKE62_RS00245	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKE62_RS00265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GKE62_RS00275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GKE62_RS00320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GKE62_RS00365	COG2205	protein histidine kinase activity
GKE62_RS00365	COG2202	Pas domain
GKE62_RS00370	COG1522	sequence-specific DNA binding
GKE62_RS00380	COG0412	Dienelactone hydrolase
GKE62_RS00385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GKE62_RS00395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GKE62_RS00400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GKE62_RS00405	COG0800	Aldolase
GKE62_RS00440	COG0424	maF-like protein
GKE62_RS00445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GKE62_RS00465	COG2267	carboxylic ester hydrolase activity
GKE62_RS00475	COG0322	excinuclease ABC activity
GKE62_RS00490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GKE62_RS00495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKE62_RS00500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GKE62_RS00505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GKE62_RS00510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GKE62_RS00530	COG0596	Alpha beta hydrolase
GKE62_RS00535	COG0300	oxidoreductase activity
GKE62_RS00540	COG1741	Belongs to the pirin family
GKE62_RS00545	COG0494	nUDIX hydrolase
GKE62_RS00590	COG5507	3-demethylubiquinone-9 3-methyltransferase
GKE62_RS00600	COG1309	transcriptional regulator
GKE62_RS00630	COG0101	tRNA pseudouridine synthase activity
GKE62_RS00635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GKE62_RS00650	COG0242	peptide deformylase activity
GKE62_RS00655	COG1322	Protein conserved in bacteria
GKE62_RS00665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKE62_RS00675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GKE62_RS00675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKE62_RS00680	COG1660	Displays ATPase and GTPase activities
GKE62_RS00685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GKE62_RS00695	COG0745	RESPONSE REGULATOR receiver
GKE62_RS00735	COG2945	thiolester hydrolase activity
GKE62_RS00750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GKE62_RS00755	COG0477	Major facilitator Superfamily
GKE62_RS00765	COG3384	dioxygenase
GKE62_RS00780	COG0542	response to heat
GKE62_RS00785	COG0187	DNA topoisomerase II activity
GKE62_RS00800	COG0792	nuclease activity
GKE62_RS00805	COG0189	ligase activity
GKE62_RS00810	COG0586	Pfam SNARE associated Golgi protein
GKE62_RS00815	COG4974	Belongs to the 'phage' integrase family
GKE62_RS00820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GKE62_RS00830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GKE62_RS00835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GKE62_RS00840	COG1420	regulation of RNA biosynthetic process
GKE62_RS00845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GKE62_RS00870	COG0443	Heat shock 70 kDa protein
GKE62_RS00875	COG0484	heat shock protein binding
GKE62_RS00910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GKE62_RS00920	COG0442	prolyl-tRNA aminoacylation
GKE62_RS00925	COG2234	aminopeptidase activity
GKE62_RS00935	COG0557	exoribonuclease II activity
GKE62_RS00945	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKE62_RS00950	COG2852	Protein conserved in bacteria
GKE62_RS00955	COG1607	acyl-coa hydrolase
GKE62_RS00960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKE62_RS01015	COG0582	viral genome integration into host DNA
GKE62_RS01025	COG2951	lytic endotransglycosylase activity
GKE62_RS01030	COG1686	Belongs to the peptidase S11 family
GKE62_RS01035	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GKE62_RS01050	COG0084	hydrolase, TatD family'
GKE62_RS01075	COG1923	regulation of RNA biosynthetic process
GKE62_RS01080	COG2204	response regulator
GKE62_RS01085	COG5000	phosphorelay sensor kinase activity
GKE62_RS01090	COG2204	response regulator
GKE62_RS01095	COG3852	Histidine kinase
GKE62_RS01105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GKE62_RS01105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GKE62_RS01115	COG1058	Belongs to the CinA family
GKE62_RS01115	COG1546	Belongs to the CinA family
GKE62_RS01125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GKE62_RS01130	COG0288	reversible hydration of carbon dioxide
GKE62_RS01160	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GKE62_RS01165	COG3830	Belongs to the UPF0237 family
GKE62_RS01165	COG0560	Phosphoserine phosphatase
GKE62_RS01170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GKE62_RS01175	COG0028	Belongs to the TPP enzyme family
GKE62_RS01185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GKE62_RS01195	COG0596	Alpha beta hydrolase
GKE62_RS01205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKE62_RS01215	COG3618	amidohydrolase
GKE62_RS01240	COG0655	NAD(P)H dehydrogenase (quinone) activity
GKE62_RS01245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GKE62_RS01265	COG0745	RESPONSE REGULATOR receiver
GKE62_RS01270	COG4772	TonB-dependent receptor
GKE62_RS01285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GKE62_RS01290	COG5002	protein histidine kinase activity
GKE62_RS01300	COG0573	inorganic phosphate transmembrane transporter activity
GKE62_RS01310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GKE62_RS01315	COG0704	Plays a role in the regulation of phosphate uptake
GKE62_RS01320	COG0745	RESPONSE REGULATOR receiver
GKE62_RS01335	COG2264	protein methyltransferase activity
GKE62_RS01375	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GKE62_RS01395	COG2267	carboxylic ester hydrolase activity
GKE62_RS01420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GKE62_RS01425	COG0385	Bile acid
GKE62_RS01430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS01435	COG2204	response regulator
GKE62_RS01440	COG4191	Histidine kinase
GKE62_RS01445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKE62_RS01470	COG0483	inositol monophosphate 1-phosphatase activity
GKE62_RS01475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GKE62_RS01485	COG0739	heme binding
GKE62_RS01490	COG1376	ErfK ybiS ycfS ynhG family protein
GKE62_RS01495	COG0352	thiamine-phosphate diphosphorylase activity
GKE62_RS01510	COG3588	fructose-bisphosphate aldolase
GKE62_RS01520	COG0126	phosphoglycerate kinase activity
GKE62_RS01525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GKE62_RS01545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GKE62_RS01590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GKE62_RS01610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GKE62_RS01620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GKE62_RS01630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GKE62_RS01670	COG2372	response to copper ion
GKE62_RS01680	COG2217	Heavy metal translocating P-type atpase
GKE62_RS01690	COG0789	Transcriptional regulator
GKE62_RS01715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GKE62_RS01745	COG0488	(ABC) transporter
GKE62_RS01775	COG0583	DNA-binding transcription factor activity
GKE62_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS01820	COG3328	transposase activity
GKE62_RS01830	COG3311	Transcriptional regulator
GKE62_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS01875	COG0028	Belongs to the TPP enzyme family
GKE62_RS01880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GKE62_RS01885	COG0215	cysteine-tRNA ligase activity
GKE62_RS01930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GKE62_RS01945	COG3046	protein related to deoxyribodipyrimidine photolyase
GKE62_RS01955	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GKE62_RS01975	COG0412	Dienelactone hydrolase
GKE62_RS01980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKE62_RS01985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GKE62_RS01990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GKE62_RS01995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GKE62_RS02000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GKE62_RS02055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKE62_RS02060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GKE62_RS02070	COG0509	glycine decarboxylation via glycine cleavage system
GKE62_RS02075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GKE62_RS02085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GKE62_RS02160	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GKE62_RS02165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GKE62_RS02170	COG2133	pyrroloquinoline quinone binding
GKE62_RS02185	COG0494	nUDIX hydrolase
GKE62_RS02190	COG0617	tRNA 3'-terminal CCA addition
GKE62_RS02195	COG3876	Protein conserved in bacteria
GKE62_RS02240	COG0789	Transcriptional regulator
GKE62_RS02245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GKE62_RS02260	COG0574	Belongs to the PEP-utilizing enzyme family
GKE62_RS02260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GKE62_RS02265	COG0751	glycine-tRNA ligase activity
GKE62_RS02270	COG0752	glycyl-tRNA synthetase alpha subunit
GKE62_RS02290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GKE62_RS02295	COG0193	aminoacyl-tRNA hydrolase activity
GKE62_RS02300	COG0012	GTP binding
GKE62_RS02325	COG2030	dehydratase
GKE62_RS02335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GKE62_RS02345	COG1792	Involved in formation and maintenance of cell shape
GKE62_RS02360	COG0772	Belongs to the SEDS family
GKE62_RS02380	COG0657	acetylesterase activity
GKE62_RS02405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GKE62_RS02415	COG2897	thiosulfate sulfurtransferase activity
GKE62_RS02420	COG0626	cystathionine gamma-synthase activity
GKE62_RS02425	COG1648	precorrin-2 dehydrogenase activity
GKE62_RS02425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKE62_RS02435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE62_RS02445	COG0175	sulfate reduction
GKE62_RS02450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE62_RS02455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GKE62_RS02490	COG1278	Cold shock
GKE62_RS02495	COG1671	Belongs to the UPF0178 family
GKE62_RS02540	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GKE62_RS02550	COG3713	MltA-interacting MipA family protein
GKE62_RS02585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GKE62_RS02600	COG0746	molybdenum cofactor guanylyltransferase activity
GKE62_RS02630	COG0625	glutathione transferase activity
GKE62_RS02650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GKE62_RS02660	COG0284	orotidine-5'-phosphate decarboxylase activity
GKE62_RS02665	COG2968	Membrane
GKE62_RS02680	COG0133	tryptophan synthase activity
GKE62_RS02685	COG2852	Protein conserved in bacteria
GKE62_RS02690	COG0159	tryptophan synthase activity
GKE62_RS02695	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GKE62_RS02700	COG0285	dihydrofolate synthase activity
GKE62_RS02705	COG2223	nitrite transmembrane transporter activity
GKE62_RS02715	COG1187	pseudouridine synthase activity
GKE62_RS02720	COG0742	ribosomal rna small subunit methyltransferase
GKE62_RS02725	COG0477	Major facilitator Superfamily
GKE62_RS02735	COG0210	DNA helicase
GKE62_RS02780	COG1024	Enoyl-CoA hydratase
GKE62_RS02785	COG0538	isocitrate dehydrogenase activity
GKE62_RS02790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKE62_RS02805	COG2066	Belongs to the glutaminase family
GKE62_RS02815	COG1970	mechanosensitive ion channel activity
GKE62_RS02835	COG0494	nUDIX hydrolase
GKE62_RS02850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GKE62_RS02855	COG1597	lipid kinase activity
GKE62_RS02860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKE62_RS02875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GKE62_RS02895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GKE62_RS02900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GKE62_RS02905	COG0741	lytic transglycosylase activity
GKE62_RS02925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GKE62_RS02930	COG0457	Tetratricopeptide repeat
GKE62_RS02935	COG4774	siderophore transport
GKE62_RS02940	COG2354	Protein conserved in bacteria
GKE62_RS02950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GKE62_RS02965	COG2119	membrane
GKE62_RS02975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GKE62_RS03010	COG0484	heat shock protein binding
GKE62_RS03015	COG2885	chlorophyll binding
GKE62_RS03020	COG0823	Involved in the tonB-independent uptake of proteins
GKE62_RS03040	COG0302	gtp cyclohydrolase
GKE62_RS03055	COG2267	carboxylic ester hydrolase activity
GKE62_RS03070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GKE62_RS03075	COG0612	Peptidase, M16
GKE62_RS03080	COG3104	oligopeptide transport
GKE62_RS03085	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GKE62_RS03090	COG0047	phosphoribosylformylglycinamidine synthase activity
GKE62_RS03100	COG2124	cytochrome p450
GKE62_RS03110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GKE62_RS03130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GKE62_RS03135	COG3746	phosphate-selective porin O and P
GKE62_RS03140	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS03150	COG1045	serine acetyltransferase
GKE62_RS03165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GKE62_RS03170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GKE62_RS03175	COG0105	UTP biosynthetic process
GKE62_RS03190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKE62_RS03195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GKE62_RS03200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GKE62_RS03205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GKE62_RS03210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GKE62_RS03235	COG3724	N-succinylarginine dihydrolase activity
GKE62_RS03245	COG1125	glycine betaine transport
GKE62_RS03295	COG0825	malonyl-CoA metabolic process
GKE62_RS03300	COG4974	Belongs to the 'phage' integrase family
GKE62_RS03315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GKE62_RS03320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GKE62_RS03325	COG0659	secondary active sulfate transmembrane transporter activity
GKE62_RS03330	COG3104	oligopeptide transport
GKE62_RS03345	COG4770	biotin carboxylase activity
GKE62_RS03350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GKE62_RS03360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE62_RS03360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GKE62_RS03370	COG1024	Enoyl-CoA hydratase
GKE62_RS03390	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GKE62_RS03405	COG0681	Belongs to the peptidase S26 family
GKE62_RS03410	COG0571	ribonuclease III activity
GKE62_RS03415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GKE62_RS03430	COG1754	DNA topoisomerase type I activity
GKE62_RS03430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GKE62_RS03435	COG3485	protocatechuate 3,4-dioxygenase
GKE62_RS03455	COG1074	ATP-dependent DNA helicase activity
GKE62_RS03465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GKE62_RS03470	COG3178	'Phosphotransferase
GKE62_RS03475	COG0802	atpase or kinase
GKE62_RS03480	COG2205	protein histidine kinase activity
GKE62_RS03485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GKE62_RS03495	COG0678	peroxiredoxin activity
GKE62_RS03515	COG0140	phosphoribosyl-ATP diphosphatase activity
GKE62_RS03525	COG0107	imidazoleglycerol-phosphate synthase activity
GKE62_RS03530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GKE62_RS03535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GKE62_RS03540	COG0131	Imidazoleglycerol-phosphate dehydratase
GKE62_RS03555	COG0194	GDP metabolic process
GKE62_RS03565	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS03570	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS03580	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS03585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GKE62_RS03600	COG2171	N-acyltransferase activity
GKE62_RS03625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKE62_RS03670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GKE62_RS03675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GKE62_RS03675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GKE62_RS03685	COG0129	dihydroxy-acid dehydratase activity
GKE62_RS03690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GKE62_RS03710	COG0521	Mo-molybdopterin cofactor biosynthetic process
GKE62_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS03745	COG0386	Belongs to the glutathione peroxidase family
GKE62_RS03750	COG1136	(ABC) transporter
GKE62_RS03755	COG4591	ABC-type transport system involved in lipoprotein release permease component
GKE62_RS03760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GKE62_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS03780	COG0415	Belongs to the DNA photolyase family
GKE62_RS03790	COG1013	pyruvate-flavodoxin oxidoreductase activity
GKE62_RS03800	COG1051	belongs to the nudix hydrolase family
GKE62_RS03810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GKE62_RS03820	COG0343	queuine tRNA-ribosyltransferase activity
GKE62_RS03825	COG0842	Transport permease protein
GKE62_RS03835	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GKE62_RS03845	COG0668	transmembrane transport
GKE62_RS03860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GKE62_RS03865	COG0142	geranyltranstransferase activity
GKE62_RS03870	COG1722	exodeoxyribonuclease VII activity
GKE62_RS03935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKE62_RS03985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GKE62_RS04005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKE62_RS04010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GKE62_RS04015	COG0071	Belongs to the small heat shock protein (HSP20) family
GKE62_RS04025	COG0504	CTP synthase activity
GKE62_RS04035	COG0149	triose-phosphate isomerase activity
GKE62_RS04055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GKE62_RS04060	COG4452	Inner membrane protein CreD
GKE62_RS04070	COG3682	Transcriptional regulator
GKE62_RS04160	COG2814	Major facilitator Superfamily
GKE62_RS04175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE62_RS04185	COG1609	Transcriptional regulator
GKE62_RS04190	COG1501	Belongs to the glycosyl hydrolase 31 family
GKE62_RS04195	COG4771	TonB-dependent receptor
GKE62_RS04210	COG2271	Major facilitator Superfamily
GKE62_RS04225	COG0488	(ABC) transporter
GKE62_RS04280	COG5265	(ABC) transporter
GKE62_RS04300	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GKE62_RS04325	COG3590	peptidase
GKE62_RS04335	COG0148	phosphopyruvate hydratase activity
GKE62_RS04365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GKE62_RS04375	COG0505	Belongs to the CarA family
GKE62_RS04390	COG0358	DNA primase activity
GKE62_RS04395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKE62_RS04415	COG0698	ribose 5-phosphate isomerase
GKE62_RS04430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKE62_RS04455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GKE62_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS04470	COG2321	neutral zinc metallopeptidase
GKE62_RS04490	COG0134	indole-3-glycerol-phosphate synthase activity
GKE62_RS04495	COG0315	cyclic pyranopterin monophosphate synthase activity
GKE62_RS04500	COG0303	'Molybdopterin
GKE62_RS04505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GKE62_RS04510	COG2333	competence protein COMEC
GKE62_RS04510	COG0658	competence protein
GKE62_RS04525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKE62_RS04530	COG0372	Belongs to the citrate synthase family
GKE62_RS04540	COG2205	protein histidine kinase activity
GKE62_RS04575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GKE62_RS04585	COG1007	ATP synthesis coupled electron transport
GKE62_RS04600	COG0713	ATP synthesis coupled electron transport
GKE62_RS04610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE62_RS04615	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GKE62_RS04620	COG1034	ATP synthesis coupled electron transport
GKE62_RS04630	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GKE62_RS04635	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GKE62_RS04640	COG0649	NAD binding
GKE62_RS04645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE62_RS04650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE62_RS04655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GKE62_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS04670	COG0183	Belongs to the thiolase family
GKE62_RS04685	COG0004	ammonium transporteR
GKE62_RS04705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKE62_RS04710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GKE62_RS04720	COG1530	ribonuclease E activity
GKE62_RS04735	COG3038	cytochrome b561
GKE62_RS04750	COG2081	HI0933 family
GKE62_RS04770	COG0784	Response regulator, receiver
GKE62_RS04770	COG2198	Histidine kinase
GKE62_RS04770	COG2205	protein histidine kinase activity
GKE62_RS04775	COG1215	transferase activity, transferring glycosyl groups
GKE62_RS04800	COG4977	sequence-specific DNA binding
GKE62_RS04810	COG0277	FAD linked oxidase domain protein
GKE62_RS04815	COG4206	TonB-dependent receptor
GKE62_RS04820	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS04825	COG2272	Belongs to the type-B carboxylesterase lipase family
GKE62_RS04830	COG3328	transposase activity
GKE62_RS04845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE62_RS04880	COG4774	siderophore transport
GKE62_RS04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE62_RS04915	COG0277	FAD linked oxidase domain protein
GKE62_RS04945	COG4771	TonB-dependent receptor
GKE62_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS05005	COG4638	Rieske (2fe-2S)
GKE62_RS05010	COG2814	Major facilitator Superfamily
GKE62_RS05020	COG4771	TonB-dependent receptor
GKE62_RS05075	COG1942	4-Oxalocrotonate Tautomerase
GKE62_RS05095	COG3971	2-oxopent-4-enoate hydratase activity
GKE62_RS05125	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GKE62_RS05130	COG4638	Rieske (2fe-2S)
GKE62_RS05145	COG4638	Rieske (2fe-2S)
GKE62_RS05150	COG0346	lactoylglutathione lyase activity
GKE62_RS05160	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GKE62_RS05200	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS05205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GKE62_RS05235	COG3971	2-oxopent-4-enoate hydratase activity
GKE62_RS05245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS05275	COG2159	amidohydrolase
GKE62_RS05285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKE62_RS05290	COG0473	3-isopropylmalate dehydrogenase activity
GKE62_RS05290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GKE62_RS05340	COG1566	PFAM secretion protein HlyD family protein
GKE62_RS05345	COG2814	Major facilitator Superfamily
GKE62_RS05365	COG2963	transposase activity
GKE62_RS05375	COG2962	Rard protein
GKE62_RS05435	COG0629	single-stranded DNA binding
GKE62_RS05490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GKE62_RS05545	COG4227	nucleotidyltransferase activity
GKE62_RS05550	COG0739	heme binding
GKE62_RS05550	COG0741	lytic transglycosylase activity
GKE62_RS05550	COG1196	nuclear chromosome segregation
GKE62_RS05570	COG2771	luxR family
GKE62_RS05575	COG3916	Acyl-homoserine-lactone synthase
GKE62_RS05610	COG0823	Involved in the tonB-independent uptake of proteins
GKE62_RS05610	COG1506	peptidase
GKE62_RS05630	COG4962	Type ii secretion system protein e
GKE62_RS05645	COG3451	type IV secretory pathway VirB4
GKE62_RS05655	COG3846	protein secretion by the type IV secretion system
GKE62_RS05660	COG3701	Conjugal transfer protein
GKE62_RS05670	COG2948	multi-organism process
GKE62_RS05680	COG0582	viral genome integration into host DNA
GKE62_RS05690	COG0583	DNA-binding transcription factor activity
GKE62_RS05715	COG0745	RESPONSE REGULATOR receiver
GKE62_RS05730	COG3273	potassium ion transport
GKE62_RS05730	COG0471	metal ion transport
GKE62_RS05780	COG2010	Cytochrome c
GKE62_RS05780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKE62_RS05785	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKE62_RS05810	COG3547	Transposase (IS116 IS110 IS902 family)
GKE62_RS05875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS05905	COG3119	arylsulfatase activity
GKE62_RS05910	COG3119	arylsulfatase activity
GKE62_RS05915	COG3250	beta-galactosidase activity
GKE62_RS05935	COG0129	dihydroxy-acid dehydratase activity
GKE62_RS05940	COG0800	Aldolase
GKE62_RS05945	COG3734	2-keto-3-deoxy-galactonokinase
GKE62_RS05960	COG2186	Transcriptional regulator
GKE62_RS05965	COG3386	PFAM SMP-30 Gluconolaconase
GKE62_RS05970	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS06035	COG3328	transposase activity
GKE62_RS06050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GKE62_RS06095	COG3360	Dodecin
GKE62_RS06105	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS06115	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS06120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS06175	COG4771	TonB-dependent receptor
GKE62_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06225	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS06230	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS06250	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS06275	COG2267	carboxylic ester hydrolase activity
GKE62_RS06280	COG1024	Enoyl-CoA hydratase
GKE62_RS06295	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS06305	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS06310	COG0657	acetylesterase activity
GKE62_RS06345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS06375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKE62_RS06420	COG4957	zinc ion binding
GKE62_RS06445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GKE62_RS06465	COG2003	Belongs to the UPF0758 family
GKE62_RS06500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GKE62_RS06545	COG2814	Major facilitator Superfamily
GKE62_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GKE62_RS06570	COG0022	dehydrogenase e1 component
GKE62_RS06595	COG4638	Rieske (2fe-2S)
GKE62_RS06610	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS06625	COG0183	Belongs to the thiolase family
GKE62_RS06635	COG2124	cytochrome p450
GKE62_RS06645	COG2130	NADP-dependent
GKE62_RS06650	COG0243	molybdopterin cofactor binding
GKE62_RS06655	COG2130	NADP-dependent
GKE62_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06675	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06680	COG1053	succinate dehydrogenase
GKE62_RS06685	COG4638	Rieske (2fe-2S)
GKE62_RS06715	COG1024	Enoyl-CoA hydratase
GKE62_RS06750	COG2130	NADP-dependent
GKE62_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS06765	COG1053	succinate dehydrogenase
GKE62_RS06775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GKE62_RS06780	COG4139	cobalamin transport
GKE62_RS06790	COG4206	TonB-dependent receptor
GKE62_RS06810	COG3300	MHYT domain
GKE62_RS06810	COG5001	Diguanylate cyclase
GKE62_RS06815	COG0039	L-malate dehydrogenase activity
GKE62_RS06820	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GKE62_RS06830	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKE62_RS06835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKE62_RS06845	COG2860	membrane
GKE62_RS06860	COG1505	serine-type exopeptidase activity
GKE62_RS06865	COG0203	ribosomal protein L17
GKE62_RS06870	COG0202	RNA polymerase activity
GKE62_RS06875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GKE62_RS06880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GKE62_RS06900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GKE62_RS06910	COG0563	adenylate kinase activity
GKE62_RS06915	COG0201	protein transport
GKE62_RS06920	COG0200	Binds to the 23S rRNA
GKE62_RS06925	COG1841	ribosomal large subunit assembly
GKE62_RS06930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GKE62_RS06935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GKE62_RS06940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GKE62_RS06945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GKE62_RS06950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GKE62_RS06955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GKE62_RS06960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GKE62_RS06965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GKE62_RS06970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GKE62_RS06975	COG0255	Belongs to the universal ribosomal protein uL29 family
GKE62_RS06980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GKE62_RS06985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GKE62_RS06990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GKE62_RS06995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GKE62_RS07000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GKE62_RS07005	COG0089	rRNA binding
GKE62_RS07010	COG0088	Forms part of the polypeptide exit tunnel
GKE62_RS07015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GKE62_RS07020	COG0051	transcription antitermination factor activity, RNA binding
GKE62_RS07025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GKE62_RS07030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GKE62_RS07035	COG0049	tRNA binding
GKE62_RS07040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GKE62_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKE62_RS07080	COG1538	Outer membrane efflux protein
GKE62_RS07085	COG3047	cAMP biosynthetic process
GKE62_RS07085	COG2885	chlorophyll binding
GKE62_RS07105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
GKE62_RS07110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS07115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKE62_RS07120	COG4133	protoheme IX ABC transporter activity
GKE62_RS07135	COG2154	pterin-4-alpha-carbinolamine dehydratase
GKE62_RS07145	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS07185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GKE62_RS07185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GKE62_RS07190	COG1196	nuclear chromosome segregation
GKE62_RS07195	COG0789	Transcriptional regulator
GKE62_RS07205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GKE62_RS07210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GKE62_RS07265	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS07280	COG0418	dihydroorotase activity
GKE62_RS07285	COG0354	folic acid binding
GKE62_RS07305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GKE62_RS07310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GKE62_RS07320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKE62_RS07330	COG0314	molybdopterin synthase activity
GKE62_RS07335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GKE62_RS07340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GKE62_RS07390	COG0596	Alpha beta hydrolase
GKE62_RS07395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GKE62_RS07400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GKE62_RS07405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GKE62_RS07410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GKE62_RS07415	COG0736	holo-[acyl-carrier-protein] synthase activity
GKE62_RS07420	COG0681	Belongs to the peptidase S26 family
GKE62_RS07425	COG0628	permease
GKE62_RS07435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GKE62_RS07450	COG1648	precorrin-2 dehydrogenase activity
GKE62_RS07450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GKE62_RS07455	COG0019	diaminopimelate decarboxylase activity
GKE62_RS07465	COG0165	Argininosuccinate lyase
GKE62_RS07485	COG1024	Enoyl-CoA hydratase
GKE62_RS07490	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS07495	COG1940	carbohydrate kinase activity
GKE62_RS07500	COG4106	trans-aconitate 2-methyltransferase activity
GKE62_RS07515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS07530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKE62_RS07545	COG1335	isochorismatase
GKE62_RS07585	COG0277	FAD linked oxidase domain protein
GKE62_RS07585	COG0277	FAD linked oxidase domain protein
GKE62_RS07600	COG4774	siderophore transport
GKE62_RS07610	COG4771	TonB-dependent receptor
GKE62_RS07630	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS07635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS07660	COG0154	amidase activity
GKE62_RS07665	COG0154	amidase activity
GKE62_RS07685	COG1024	Enoyl-CoA hydratase
GKE62_RS07695	COG2267	carboxylic ester hydrolase activity
GKE62_RS07715	COG0739	heme binding
GKE62_RS07770	COG4964	Belongs to the GSP D family
GKE62_RS07815	COG2226	methyltransferase
GKE62_RS07830	COG4774	siderophore transport
GKE62_RS07835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GKE62_RS07840	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS07860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKE62_RS07865	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS07875	COG1609	Transcriptional regulator
GKE62_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS07885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKE62_RS07925	COG2211	Major facilitator Superfamily
GKE62_RS07965	COG0457	Tetratricopeptide repeat
GKE62_RS08000	COG2211	Major facilitator Superfamily
GKE62_RS08025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GKE62_RS08030	COG0616	signal peptide processing
GKE62_RS08035	COG0540	Belongs to the ATCase OTCase family
GKE62_RS08040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKE62_RS08065	COG2311	Membrane
GKE62_RS08075	COG2193	ferroxidase activity
GKE62_RS08080	COG1160	GTP binding
GKE62_RS08105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GKE62_RS08110	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GKE62_RS08125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GKE62_RS08145	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GKE62_RS08150	COG1426	Protein conserved in bacteria
GKE62_RS08160	COG0037	tRNA processing
GKE62_RS08185	COG1758	RNA polymerase activity
GKE62_RS08190	COG0305	Participates in initiation and elongation during chromosome replication
GKE62_RS08195	COG5328	Belongs to the UPF0262 family
GKE62_RS08205	COG0295	cytidine deaminase activity
GKE62_RS08210	COG0717	Belongs to the dCTP deaminase family
GKE62_RS08245	COG0861	Integral membrane protein TerC family
GKE62_RS08250	COG0514	ATP-dependent DNA helicase (RecQ)
GKE62_RS08270	COG0646	methionine synthase
GKE62_RS08270	COG1410	methionine synthase
GKE62_RS08285	COG0640	Transcriptional regulator
GKE62_RS08300	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GKE62_RS08310	COG0564	pseudouridine synthase activity
GKE62_RS08325	COG0433	COG0433 Predicted ATPase
GKE62_RS08330	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS08335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GKE62_RS08345	COG0583	DNA-binding transcription factor activity
GKE62_RS08350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GKE62_RS08365	COG1850	ribulose-bisphosphate carboxylase activity
GKE62_RS08370	COG4451	ribulose bisphosphate carboxylase, small
GKE62_RS08390	COG0546	phosphoglycolate phosphatase activity
GKE62_RS08395	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GKE62_RS08400	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GKE62_RS08405	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GKE62_RS08425	COG0500	methyltransferase
GKE62_RS08430	COG1063	alcohol dehydrogenase
GKE62_RS08435	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GKE62_RS08440	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GKE62_RS08445	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GKE62_RS08480	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GKE62_RS08485	COG0644	oxidoreductase
GKE62_RS08490	COG2211	Major facilitator Superfamily
GKE62_RS08495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GKE62_RS08515	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GKE62_RS08525	COG1429	ligase activity, forming nitrogen-metal bonds
GKE62_RS08530	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GKE62_RS08565	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GKE62_RS08575	COG0156	8-amino-7-oxononanoate synthase activity
GKE62_RS08605	COG2226	methyltransferase
GKE62_RS08605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE62_RS08605	COG0596	Alpha beta hydrolase
GKE62_RS08615	COG3328	transposase activity
GKE62_RS08640	COG4638	Rieske (2fe-2S)
GKE62_RS08655	COG4774	siderophore transport
GKE62_RS08660	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GKE62_RS08665	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS08680	COG0183	Belongs to the thiolase family
GKE62_RS08695	COG0243	molybdopterin cofactor binding
GKE62_RS08700	COG3119	arylsulfatase activity
GKE62_RS08715	COG1902	pentaerythritol trinitrate reductase activity
GKE62_RS08795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GKE62_RS08800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GKE62_RS08805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKE62_RS08815	COG5508	conserved small protein
GKE62_RS08820	COG0459	protein refolding
GKE62_RS08825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKE62_RS08840	COG5425	PFAM Usg family protein
GKE62_RS08845	COG0156	8-amino-7-oxononanoate synthase activity
GKE62_RS08905	COG0747	negative chemotaxis
GKE62_RS08915	COG3158	transport of potassium into the cell
GKE62_RS08950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKE62_RS08950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GKE62_RS08955	COG3920	Histidine kinase
GKE62_RS08990	COG2070	2-Nitropropane dioxygenase
GKE62_RS09005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GKE62_RS09010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GKE62_RS09020	COG2890	protein-(glutamine-N5) methyltransferase activity
GKE62_RS09025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GKE62_RS09045	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GKE62_RS09050	COG0312	modulator of DNA gyrase
GKE62_RS09060	COG1137	ATPase activity
GKE62_RS09090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GKE62_RS09105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GKE62_RS09130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GKE62_RS09135	COG2032	superoxide dismutase activity
GKE62_RS09140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS09160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GKE62_RS09170	COG2095	MarC family integral membrane protein
GKE62_RS09180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GKE62_RS09185	COG0762	integral membrane protein
GKE62_RS09195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GKE62_RS09205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GKE62_RS09210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GKE62_RS09220	COG0281	malic enzyme
GKE62_RS09220	COG0280	phosphate acetyltransferase
GKE62_RS09240	COG0730	response to heat
GKE62_RS09265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GKE62_RS09270	COG2326	polyphosphate kinase activity
GKE62_RS09275	COG3186	Phenylalanine-4-hydroxylase
GKE62_RS09290	COG1968	undecaprenyl-diphosphatase activity
GKE62_RS09300	COG3590	peptidase
GKE62_RS09305	COG1132	(ABC) transporter
GKE62_RS09325	COG0183	Belongs to the thiolase family
GKE62_RS09340	COG0438	transferase activity, transferring glycosyl groups
GKE62_RS09350	COG0069	glutamate synthase activity
GKE62_RS09350	COG0070	glutamate synthase
GKE62_RS09350	COG0067	glutamate synthase
GKE62_RS09370	COG1201	RNA secondary structure unwinding
GKE62_RS09410	COG1494	fructose-1,6-bisphosphatase
GKE62_RS09415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GKE62_RS09425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GKE62_RS09430	COG0085	RNA polymerase activity
GKE62_RS09445	COG3655	Transcriptional regulator
GKE62_RS09450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GKE62_RS09455	COG0222	ribosome binding
GKE62_RS09470	COG0519	Catalyzes the synthesis of GMP from XMP
GKE62_RS09470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GKE62_RS09500	COG0312	modulator of DNA gyrase
GKE62_RS09510	COG1131	(ABC) transporter
GKE62_RS09540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GKE62_RS09540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKE62_RS09560	COG1372	Participates in initiation and elongation during chromosome replication
GKE62_RS09560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GKE62_RS09590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GKE62_RS09595	COG3813	Protein conserved in bacteria
GKE62_RS09600	COG0351	phosphomethylpyrimidine kinase
GKE62_RS09620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GKE62_RS09635	COG0077	Prephenate dehydratase
GKE62_RS09635	COG1605	Chorismate mutase
GKE62_RS09650	COG0714	Associated with various cellular activities
GKE62_RS09685	COG0081	regulation of translation
GKE62_RS09690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GKE62_RS09705	COG0250	Participates in transcription elongation, termination and antitermination
GKE62_RS09725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GKE62_RS09755	COG4191	Histidine kinase
GKE62_RS09755	COG0784	Response regulator, receiver
GKE62_RS09760	COG3172	ATPase kinase involved in NAD metabolism
GKE62_RS09765	COG3201	nicotinamide mononucleotide transporter
GKE62_RS09770	COG1393	Belongs to the ArsC family
GKE62_RS09780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GKE62_RS09785	COG1301	dicarboxylic acid transport
GKE62_RS09790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GKE62_RS09795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GKE62_RS09800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GKE62_RS09810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GKE62_RS09815	COG0268	Binds directly to 16S ribosomal RNA
GKE62_RS09820	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GKE62_RS09840	COG0482	sulfurtransferase activity
GKE62_RS09860	COG2733	membrane
GKE62_RS09875	COG2086	electron transfer activity
GKE62_RS09880	COG0045	succinate-CoA ligase (ADP-forming) activity
GKE62_RS09885	COG1218	3'(2'),5'-bisphosphate nucleotidase
GKE62_RS09890	COG0667	Aldo Keto reductase
GKE62_RS09895	COG2885	chlorophyll binding
GKE62_RS09900	COG1253	flavin adenine dinucleotide binding
GKE62_RS09910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GKE62_RS09920	COG0196	riboflavin kinase activity
GKE62_RS09930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GKE62_RS09935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GKE62_RS09940	COG0588	phosphoglycerate mutase activity
GKE62_RS09985	COG1496	oxidoreductase activity
GKE62_RS10000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GKE62_RS10005	COG0594	ribonuclease P activity
GKE62_RS10010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GKE62_RS10015	COG0706	membrane insertase activity
GKE62_RS10020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GKE62_RS10035	COG0625	glutathione transferase activity
GKE62_RS10045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GKE62_RS10060	COG4395	Tim44
GKE62_RS10065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GKE62_RS10075	COG0180	Tryptophanyl-tRNA synthetase
GKE62_RS10085	COG0756	dUTP diphosphatase activity
GKE62_RS10090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GKE62_RS10110	COG1192	Involved in chromosome partitioning
GKE62_RS10115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GKE62_RS10125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GKE62_RS10150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GKE62_RS10155	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS10160	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GKE62_RS10195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GKE62_RS10200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GKE62_RS10215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GKE62_RS10220	COG0072	phenylalanine-tRNA ligase activity
GKE62_RS10230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GKE62_RS10285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GKE62_RS10290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GKE62_RS10295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GKE62_RS10300	COG0237	dephospho-CoA kinase activity
GKE62_RS10305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GKE62_RS10310	COG0424	maF-like protein
GKE62_RS10315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GKE62_RS10320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GKE62_RS10325	COG1981	membrane
GKE62_RS10330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GKE62_RS10355	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GKE62_RS10360	COG0445	tRNA wobble uridine modification
GKE62_RS10365	COG0357	Ribosomal RNA small subunit methyltransferase G
GKE62_RS10410	COG1956	GAF domain-containing protein
GKE62_RS10425	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS10430	COG0009	L-threonylcarbamoyladenylate synthase
GKE62_RS10445	COG1329	Transcriptional regulator
GKE62_RS10450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GKE62_RS10465	COG1196	nuclear chromosome segregation
GKE62_RS10465	COG0741	lytic transglycosylase activity
GKE62_RS10465	COG0739	heme binding
GKE62_RS10470	COG0113	porphobilinogen synthase activity
GKE62_RS10475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GKE62_RS10490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GKE62_RS10500	COG1793	dna ligase
GKE62_RS10505	COG1793	dna ligase
GKE62_RS10505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GKE62_RS10525	COG4221	oxidoreductase activity
GKE62_RS10525	COG3321	synthase
GKE62_RS10525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GKE62_RS10525	COG0604	alcohol dehydrogenase
GKE62_RS10530	COG0625	glutathione transferase activity
GKE62_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS10550	COG0739	heme binding
GKE62_RS10555	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GKE62_RS10565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GKE62_RS10570	COG0799	negative regulation of ribosome biogenesis
GKE62_RS10575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GKE62_RS10585	COG0793	Belongs to the peptidase S41A family
GKE62_RS10595	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GKE62_RS10620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GKE62_RS10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GKE62_RS10690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GKE62_RS10700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GKE62_RS10705	COG1295	ribonuclease BN
GKE62_RS10710	COG0484	heat shock protein binding
GKE62_RS10730	COG0753	catalase activity
GKE62_RS10805	COG0071	Belongs to the small heat shock protein (HSP20) family
GKE62_RS10810	COG3328	transposase activity
GKE62_RS10835	COG1297	OPT oligopeptide transporter protein
GKE62_RS10840	COG1597	lipid kinase activity
GKE62_RS10850	COG5410	chromosome segregation
GKE62_RS10860	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GKE62_RS10865	COG0259	pyridoxamine-phosphate oxidase activity
GKE62_RS10895	COG1674	ftsk spoiiie
GKE62_RS10900	COG0475	glutathione-regulated potassium exporter activity
GKE62_RS10900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GKE62_RS10915	COG0686	Belongs to the AlaDH PNT family
GKE62_RS10920	COG3706	GGDEF domain
GKE62_RS10955	COG0642	Histidine kinase
GKE62_RS10995	COG2814	Major facilitator Superfamily
GKE62_RS11005	COG0306	phosphate transporter
GKE62_RS11010	COG1392	Phosphate transport regulator
GKE62_RS11045	COG0863	Belongs to the N(4) N(6)-methyltransferase family
GKE62_RS11055	COG1476	TRANSCRIPTIONal
GKE62_RS11070	COG1741	Belongs to the pirin family
GKE62_RS11075	COG1764	response to oxidative stress
GKE62_RS11095	COG1335	isochorismatase
GKE62_RS11105	COG0583	DNA-binding transcription factor activity
GKE62_RS11115	COG2072	flavoprotein involved in K transport
GKE62_RS11135	COG2814	Major facilitator Superfamily
GKE62_RS11150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GKE62_RS11155	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS11170	COG0583	DNA-binding transcription factor activity
GKE62_RS11190	COG0657	acetylesterase activity
GKE62_RS11240	COG1959	2 iron, 2 sulfur cluster binding
GKE62_RS11245	COG1017	nitric oxide dioxygenase activity
GKE62_RS11245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GKE62_RS11290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GKE62_RS11305	COG2884	Cell division ATP-binding protein ftsE
GKE62_RS11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GKE62_RS11335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE62_RS11340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE62_RS11340	COG2813	Specifically methylates the guanine in position
GKE62_RS11350	COG2957	Belongs to the agmatine deiminase family
GKE62_RS11370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GKE62_RS11375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GKE62_RS11385	COG0739	heme binding
GKE62_RS11410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GKE62_RS11415	COG2059	Chromate
GKE62_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS11470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GKE62_RS11480	COG3093	addiction module antidote protein HigA
GKE62_RS11495	COG2885	chlorophyll binding
GKE62_RS11495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GKE62_RS11505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GKE62_RS11525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GKE62_RS11530	COG1278	Cold shock
GKE62_RS11550	COG0004	ammonium transporteR
GKE62_RS11555	COG0347	Belongs to the P(II) protein family
GKE62_RS11575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GKE62_RS11585	COG4774	siderophore transport
GKE62_RS11615	COG0151	Belongs to the GarS family
GKE62_RS11620	COG1570	exodeoxyribonuclease VII activity
GKE62_RS11635	COG4206	TonB-dependent receptor
GKE62_RS11655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GKE62_RS11660	COG0590	tRNA wobble adenosine to inosine editing
GKE62_RS11685	COG3275	phosphorelay sensor kinase activity
GKE62_RS11705	COG0501	Belongs to the peptidase M48B family
GKE62_RS11710	COG0657	acetylesterase activity
GKE62_RS11720	COG2814	Major facilitator Superfamily
GKE62_RS11750	COG3300	MHYT domain
GKE62_RS11750	COG5001	Diguanylate cyclase
GKE62_RS11810	COG1595	DNA-templated transcription, initiation
GKE62_RS11840	COG0469	pyruvate kinase activity
GKE62_RS11850	COG3750	Belongs to the UPF0335 family
GKE62_RS11855	COG1228	amidohydrolase
GKE62_RS11860	COG0393	Putative heavy-metal-binding
GKE62_RS11865	COG0217	transcriptional regulatory protein
GKE62_RS11875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GKE62_RS11880	COG0632	four-way junction helicase activity
GKE62_RS11895	COG2255	four-way junction helicase activity
GKE62_RS11910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GKE62_RS11930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKE62_RS11975	COG0582	viral genome integration into host DNA
GKE62_RS12000	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS12035	COG2072	flavoprotein involved in K transport
GKE62_RS12070	COG0730	response to heat
GKE62_RS12080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GKE62_RS12095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GKE62_RS12100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GKE62_RS12110	COG3023	N-Acetylmuramoyl-L-alanine amidase
GKE62_RS12130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GKE62_RS12155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GKE62_RS12170	COG0544	peptidyl-prolyl cis-trans isomerase activity
GKE62_RS12190	COG2022	thiamine diphosphate biosynthetic process
GKE62_RS12200	COG1612	heme a metabolic process
GKE62_RS12210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GKE62_RS12215	COG0583	DNA-binding transcription factor activity
GKE62_RS12225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GKE62_RS12240	COG0316	Belongs to the HesB IscA family
GKE62_RS12245	COG2151	metal-sulfur cluster biosynthetic enzyme
GKE62_RS12255	COG0719	Fe-S assembly protein
GKE62_RS12260	COG0396	ATPase activity
GKE62_RS12270	COG0719	Fe-S assembly protein
GKE62_RS12285	COG0167	dihydroorotate dehydrogenase activity
GKE62_RS12290	COG0405	Gamma-glutamyltransferase
GKE62_RS12295	COG1022	Amp-dependent synthetase and ligase
GKE62_RS12305	COG2234	aminopeptidase activity
GKE62_RS12310	COG1024	Enoyl-CoA hydratase
GKE62_RS12315	COG0436	Aminotransferase
GKE62_RS12320	COG3243	poly(R)-hydroxyalkanoic acid synthase
GKE62_RS12375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GKE62_RS12385	COG0784	Response regulator, receiver
GKE62_RS12390	COG3920	Histidine kinase
GKE62_RS12410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GKE62_RS12425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GKE62_RS12435	COG2096	Adenosyltransferase
GKE62_RS12440	COG1250	3-hydroxyacyl-CoA dehydrogenase
GKE62_RS12465	COG0330	HflC and HflK could
GKE62_RS12485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GKE62_RS12500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GKE62_RS12505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GKE62_RS12510	COG1585	Membrane protein implicated in regulation of membrane protease activity
GKE62_RS12515	COG0330	HflC and HflK could
GKE62_RS12540	COG0235	Class ii aldolase
GKE62_RS12545	COG2080	2 iron, 2 sulfur cluster binding
GKE62_RS12555	COG3128	pkhd-type hydroxylase
GKE62_RS12570	COG2866	Carboxypeptidase
GKE62_RS12585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GKE62_RS12600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GKE62_RS12615	COG0527	aspartate kinase activity
GKE62_RS12620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GKE62_RS12640	COG1482	cell wall glycoprotein biosynthetic process
GKE62_RS12650	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GKE62_RS12655	COG0438	transferase activity, transferring glycosyl groups
GKE62_RS12665	COG0784	Response regulator, receiver
GKE62_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS12685	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS12700	COG2223	nitrite transmembrane transporter activity
GKE62_RS12710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GKE62_RS12730	COG0492	ferredoxin-NADP+ reductase activity
GKE62_RS12735	COG0534	Mate efflux family protein
GKE62_RS12740	COG0602	queuosine metabolic process
GKE62_RS12745	COG0525	valine-tRNA ligase activity
GKE62_RS12750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GKE62_RS12785	COG0546	phosphoglycolate phosphatase activity
GKE62_RS12790	COG0564	pseudouridine synthase activity
GKE62_RS12795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GKE62_RS12800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKE62_RS12805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GKE62_RS12810	COG0805	protein transport
GKE62_RS12820	COG0631	protein serine/threonine phosphatase activity
GKE62_RS12880	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS12885	COG1024	Enoyl-CoA hydratase
GKE62_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS12905	COG1064	alcohol dehydrogenase
GKE62_RS12910	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS12920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GKE62_RS12925	COG0545	Peptidyl-prolyl cis-trans isomerase
GKE62_RS12930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKE62_RS12935	COG0154	amidase activity
GKE62_RS12940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GKE62_RS12975	COG1678	Uncharacterized ACR, COG1678
GKE62_RS12995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GKE62_RS13000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GKE62_RS13005	COG0328	RNA-DNA hybrid ribonuclease activity
GKE62_RS13010	COG3422	double-strand break repair
GKE62_RS13035	COG4964	Belongs to the GSP D family
GKE62_RS13070	COG0625	glutathione transferase activity
GKE62_RS13080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GKE62_RS13095	COG0542	response to heat
GKE62_RS13100	COG1472	Belongs to the glycosyl hydrolase 3 family
GKE62_RS13105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GKE62_RS13110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GKE62_RS13135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GKE62_RS13140	COG0024	Methionine aminopeptidase
GKE62_RS13145	COG0347	Belongs to the P(II) protein family
GKE62_RS13150	COG0174	glutamine synthetase
GKE62_RS13190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GKE62_RS13205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GKE62_RS13215	COG2084	Dehydrogenase
GKE62_RS13220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GKE62_RS13240	COG2188	Transcriptional regulator
GKE62_RS13260	COG3220	belongs to the UPF0276 family
GKE62_RS13270	COG0446	pyridine nucleotide-disulphide oxidoreductase
GKE62_RS13280	COG0583	DNA-binding transcription factor activity
GKE62_RS13335	COG4152	abc transporter atp-binding protein
GKE62_RS13340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GKE62_RS13350	COG2902	Dehydrogenase
GKE62_RS13355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE62_RS13375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GKE62_RS13395	COG3577	Aspartyl protease
GKE62_RS13400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GKE62_RS13410	COG1213	nucleotidyl transferase
GKE62_RS13430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GKE62_RS13435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GKE62_RS13450	COG3321	synthase
GKE62_RS13450	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS13450	COG0604	alcohol dehydrogenase
GKE62_RS13455	COG0066	3-isopropylmalate dehydratase activity
GKE62_RS13470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKE62_RS13485	COG2832	Protein of unknown function (DUF454)
GKE62_RS13490	COG2166	iron-sulfur cluster assembly
GKE62_RS13525	COG1842	Phage shock protein A
GKE62_RS13535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GKE62_RS13545	COG0779	Required for maturation of 30S ribosomal subunits
GKE62_RS13560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GKE62_RS13575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GKE62_RS13580	COG1435	thymidine kinase activity
GKE62_RS13585	COG1994	Peptidase M50
GKE62_RS13590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GKE62_RS13595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GKE62_RS13600	COG1185	polyribonucleotide nucleotidyltransferase activity
GKE62_RS13620	COG1294	oxidase, subunit
GKE62_RS13635	COG0842	Transport permease protein
GKE62_RS13665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKE62_RS13680	COG1217	gtp-binding protein TYPA
GKE62_RS13685	COG4771	TonB-dependent receptor
GKE62_RS13690	COG3152	Membrane
GKE62_RS13700	COG4181	ATPase activity
GKE62_RS13710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GKE62_RS13735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GKE62_RS13775	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS13790	COG4977	sequence-specific DNA binding
GKE62_RS13790	COG1917	Cupin 2, conserved barrel domain protein
GKE62_RS13795	COG4771	TonB-dependent receptor
GKE62_RS13800	COG0156	8-amino-7-oxononanoate synthase activity
GKE62_RS13820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GKE62_RS13825	COG0402	S-adenosylhomocysteine deaminase activity
GKE62_RS13830	COG1522	sequence-specific DNA binding
GKE62_RS13885	COG0596	Alpha beta hydrolase
GKE62_RS13885	COG0508	dehydrogenase complex catalyzes the overall conversion of
GKE62_RS13890	COG0277	FAD linked oxidase domain protein
GKE62_RS13900	COG4948	Mandelate Racemase Muconate Lactonizing
GKE62_RS13905	COG1505	serine-type exopeptidase activity
GKE62_RS13910	COG4771	TonB-dependent receptor
GKE62_RS13920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GKE62_RS13925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKE62_RS13945	COG3104	oligopeptide transport
GKE62_RS13970	COG4771	TonB-dependent receptor
GKE62_RS13995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GKE62_RS14005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GKE62_RS14045	COG0427	acetyl-CoA hydrolase
GKE62_RS14050	COG1063	alcohol dehydrogenase
GKE62_RS14060	COG0628	permease
GKE62_RS14065	COG2346	COG2346, Truncated hemoglobins
GKE62_RS14135	COG4957	zinc ion binding
GKE62_RS14140	COG3360	Dodecin
GKE62_RS14145	COG0667	Aldo Keto reductase
GKE62_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS14170	COG2205	protein histidine kinase activity
GKE62_RS14175	COG0745	RESPONSE REGULATOR receiver
GKE62_RS14200	COG2239	Acts as a magnesium transporter
GKE62_RS14215	COG0583	DNA-binding transcription factor activity
GKE62_RS14220	COG1253	flavin adenine dinucleotide binding
GKE62_RS14225	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GKE62_RS14250	COG0138	bifunctional purine biosynthesis protein purh
GKE62_RS14270	COG0454	-acetyltransferase
GKE62_RS14280	COG1546	Belongs to the CinA family
GKE62_RS14280	COG1058	Belongs to the CinA family
GKE62_RS14320	COG1260	myo-inositol-1-phosphate synthase
GKE62_RS14325	COG4750	Nucleotidyl transferase
GKE62_RS14360	COG0778	Nitroreductase
GKE62_RS14370	COG0545	Peptidyl-prolyl cis-trans isomerase
GKE62_RS14375	COG0612	Peptidase, M16
GKE62_RS14405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GKE62_RS14425	COG0275	rRNA processing
GKE62_RS14440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GKE62_RS14450	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GKE62_RS14455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GKE62_RS14465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GKE62_RS14475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GKE62_RS14480	COG1181	Belongs to the D-alanine--D-alanine ligase family
GKE62_RS14485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GKE62_RS14490	COG0849	cell division
GKE62_RS14515	COG0670	Belongs to the BI1 family
GKE62_RS14530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GKE62_RS14540	COG0356	it plays a direct role in the translocation of protons across the membrane
GKE62_RS14545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GKE62_RS14550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKE62_RS14555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GKE62_RS14560	COG3321	synthase
GKE62_RS14560	COG0604	alcohol dehydrogenase
GKE62_RS14560	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS14565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE62_RS14570	COG0539	negative regulation of cytoplasmic translation
GKE62_RS14575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GKE62_RS14585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GKE62_RS14620	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS14650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GKE62_RS14665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GKE62_RS14670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKE62_RS14675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GKE62_RS14690	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GKE62_RS14705	COG0582	viral genome integration into host DNA
GKE62_RS14725	COG3328	transposase activity
GKE62_RS14755	COG3844	kynureninase activity
GKE62_RS14760	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GKE62_RS14785	COG4172	Belongs to the ABC transporter superfamily
GKE62_RS14795	COG0601	transmembrane transport
GKE62_RS14800	COG0601	transmembrane transport
GKE62_RS14865	COG2819	hydrolase of the alpha beta superfamily
GKE62_RS14870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GKE62_RS14885	COG1476	TRANSCRIPTIONal
GKE62_RS14895	COG4948	Mandelate Racemase Muconate Lactonizing
GKE62_RS14915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GKE62_RS14925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GKE62_RS14940	COG4774	siderophore transport
GKE62_RS14945	COG1309	transcriptional regulator
GKE62_RS14950	COG2267	carboxylic ester hydrolase activity
GKE62_RS15005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKE62_RS15010	COG3360	Dodecin
GKE62_RS15015	COG3550	peptidyl-serine autophosphorylation
GKE62_RS15060	COG3158	transport of potassium into the cell
GKE62_RS15115	COG4771	TonB-dependent receptor
GKE62_RS15125	COG2723	6-phospho-beta-galactosidase activity
GKE62_RS15130	COG0517	IMP dehydrogenase activity
GKE62_RS15135	COG4974	Belongs to the 'phage' integrase family
GKE62_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15180	COG2130	NADP-dependent
GKE62_RS15205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GKE62_RS15210	COG2204	response regulator
GKE62_RS15215	COG4191	Histidine kinase
GKE62_RS15220	COG1301	dicarboxylic acid transport
GKE62_RS15240	COG1966	Carbon starvation protein
GKE62_RS15260	COG0477	Major facilitator Superfamily
GKE62_RS15300	COG4771	TonB-dependent receptor
GKE62_RS15315	COG2226	methyltransferase
GKE62_RS15320	COG2207	Transcriptional regulator
GKE62_RS15320	COG3708	Transcriptional regulator
GKE62_RS15340	COG3547	Transposase (IS116 IS110 IS902 family)
GKE62_RS15350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GKE62_RS15390	COG1846	Transcriptional regulator
GKE62_RS15395	COG1764	response to oxidative stress
GKE62_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15405	COG3321	synthase
GKE62_RS15405	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15405	COG0604	alcohol dehydrogenase
GKE62_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15420	COG3328	transposase activity
GKE62_RS15435	COG2814	Major facilitator Superfamily
GKE62_RS15455	COG1309	transcriptional regulator
GKE62_RS15465	COG5001	Diguanylate cyclase
GKE62_RS15465	COG3300	MHYT domain
GKE62_RS15480	COG5001	Diguanylate cyclase
GKE62_RS15480	COG3300	MHYT domain
GKE62_RS15510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GKE62_RS15540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GKE62_RS15545	COG0459	protein refolding
GKE62_RS15560	COG1597	lipid kinase activity
GKE62_RS15615	COG0071	Belongs to the small heat shock protein (HSP20) family
GKE62_RS15655	COG1058	Belongs to the CinA family
GKE62_RS15655	COG1546	Belongs to the CinA family
GKE62_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GKE62_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS15745	COG3920	Histidine kinase
GKE62_RS15745	COG2202	Pas domain
GKE62_RS15750	COG4191	Histidine kinase
GKE62_RS15750	COG0784	Response regulator, receiver
GKE62_RS15775	COG2207	Transcriptional regulator
GKE62_RS15775	COG0662	Cupin 2, conserved barrel domain protein
GKE62_RS15840	COG4774	siderophore transport
GKE62_RS15860	COG1609	Transcriptional regulator
GKE62_RS15885	COG2814	Major facilitator Superfamily
GKE62_RS15895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GKE62_RS15955	COG4771	TonB-dependent receptor
GKE62_RS15995	COG4771	TonB-dependent receptor
GKE62_RS16005	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS16010	COG2130	NADP-dependent
GKE62_RS16015	COG4771	TonB-dependent receptor
GKE62_RS16020	COG1522	sequence-specific DNA binding
GKE62_RS16040	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS16050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GKE62_RS16105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS16110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS16115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS16135	COG0667	Aldo Keto reductase
GKE62_RS16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GKE62_RS16170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GKE62_RS16175	COG1335	isochorismatase
GKE62_RS16180	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GKE62_RS16190	COG0357	Ribosomal RNA small subunit methyltransferase G
GKE62_RS16215	COG2211	Major facilitator Superfamily
GKE62_RS16225	COG4771	TonB-dependent receptor
GKE62_RS16250	COG0154	amidase activity
GKE62_RS16255	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS16275	COG2226	methyltransferase
GKE62_RS16275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GKE62_RS16275	COG0596	Alpha beta hydrolase
GKE62_RS16295	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS16310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GKE62_RS16315	COG0066	3-isopropylmalate dehydratase activity
GKE62_RS16320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GKE62_RS16340	COG0318	PFAM AMP-dependent synthetase and ligase
GKE62_RS16345	COG2070	2-Nitropropane dioxygenase
GKE62_RS16355	COG2814	Major facilitator Superfamily
GKE62_RS16390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GKE62_RS16395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS16405	COG1566	PFAM secretion protein HlyD family protein
GKE62_RS16410	COG2814	Major facilitator Superfamily
GKE62_RS16425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKE62_RS16475	COG1204	response to ionizing radiation
GKE62_RS16485	COG0717	Belongs to the dCTP deaminase family
GKE62_RS16545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GKE62_RS16575	COG1381	Involved in DNA repair and RecF pathway recombination
GKE62_RS16580	COG0473	3-isopropylmalate dehydrogenase activity
GKE62_RS16590	COG1505	serine-type exopeptidase activity
GKE62_RS16620	COG2967	ApaG domain
GKE62_RS16625	COG0583	DNA-binding transcription factor activity
GKE62_RS16640	COG0129	dihydroxy-acid dehydratase activity
GKE62_RS16645	COG0837	glucose binding
GKE62_RS16655	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GKE62_RS16665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GKE62_RS16695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GKE62_RS16715	COG1902	pentaerythritol trinitrate reductase activity
GKE62_RS16725	COG0321	lipoyl(octanoyl) transferase activity
GKE62_RS16765	COG0583	DNA-binding transcription factor activity
GKE62_RS16785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GKE62_RS16820	COG0183	Belongs to the thiolase family
GKE62_RS16825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GKE62_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS16845	COG1012	belongs to the aldehyde dehydrogenase family
GKE62_RS16850	COG0183	Belongs to the thiolase family
GKE62_RS16860	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS16870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GKE62_RS16875	COG0156	8-amino-7-oxononanoate synthase activity
GKE62_RS16885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GKE62_RS16890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GKE62_RS16905	COG0483	inositol monophosphate 1-phosphatase activity
GKE62_RS16910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GKE62_RS16965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GKE62_RS16980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GKE62_RS16985	COG0416	fatty acid biosynthetic process
GKE62_RS16990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GKE62_RS16995	COG0776	regulation of translation
GKE62_RS17005	COG0439	Biotin carboxylase
GKE62_RS17010	COG0511	ligase activity, forming carbon-carbon bonds
GKE62_RS17015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GKE62_RS17045	COG1862	Preprotein translocase
GKE62_RS17050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKE62_RS17055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GKE62_RS17060	COG0438	transferase activity, transferring glycosyl groups
GKE62_RS17080	COG0488	(ABC) transporter
GKE62_RS17110	COG0142	geranyltranstransferase activity
GKE62_RS17135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GKE62_RS17145	COG0776	regulation of translation
GKE62_RS17155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GKE62_RS17170	COG0688	phosphatidylethanolamine metabolic process
GKE62_RS17185	COG0052	Belongs to the universal ribosomal protein uS2 family
GKE62_RS17195	COG0528	UMP kinase activity
GKE62_RS17200	COG0233	cytoplasmic translational termination
GKE62_RS17205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GKE62_RS17210	COG0575	Belongs to the CDS family
GKE62_RS17215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GKE62_RS17220	COG0750	zinc metalloprotease
GKE62_RS17235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GKE62_RS17240	COG0254	rRNA binding
GKE62_RS17250	COG1733	regulation of RNA biosynthetic process
GKE62_RS17295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GKE62_RS17300	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GKE62_RS17305	COG1138	Cytochrome C-type biogenesis protein
GKE62_RS17310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GKE62_RS17315	COG4235	cytochrome complex assembly
GKE62_RS17315	COG3088	subunit of a heme lyase
GKE62_RS17325	COG3158	transport of potassium into the cell
GKE62_RS17340	COG2917	probably involved in intracellular septation
GKE62_RS17345	COG0552	protein localization to endoplasmic reticulum
GKE62_RS17350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GKE62_RS17355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GKE62_RS17360	COG5001	Diguanylate cyclase
GKE62_RS17360	COG3300	MHYT domain
GKE62_RS17365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GKE62_RS17370	COG0228	four-way junction DNA binding
GKE62_RS17375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GKE62_RS17380	COG0336	Belongs to the RNA methyltransferase TrmD family
GKE62_RS17385	COG0335	large ribosomal subunit rRNA binding
GKE62_RS17390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GKE62_RS17450	COG0360	Binds together with S18 to 16S ribosomal RNA
GKE62_RS17455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GKE62_RS17460	COG0359	binds to the 23S rRNA
GKE62_RS17470	COG3706	GGDEF domain
GKE62_RS17475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GKE62_RS17480	COG1619	proteins homologs of microcin C7 resistance protein MccF
GKE62_RS17485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GKE62_RS17505	COG3321	synthase
GKE62_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS17505	COG0604	alcohol dehydrogenase
GKE62_RS17525	COG3300	MHYT domain
GKE62_RS17525	COG5001	Diguanylate cyclase
GKE62_RS17530	COG0481	GTPase activity
GKE62_RS17735	COG4372	Transposase
GKE62_RS17740	COG3436	PFAM IS66 Orf2 family protein
GKE62_RS17745	COG2963	transposase activity
GKE62_RS17870	COG0582	viral genome integration into host DNA
GKE62_RS17900	COG4983	Phage plasmid primase, P4 family domain protein
GKE62_RS17915	COG1696	Membrane protein involved in D-alanine export
GKE62_RS17925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GKE62_RS17940	COG1448	Aminotransferase
GKE62_RS17955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKE62_RS17955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GKE62_RS17970	COG2983	Belongs to the UPF0260 family
GKE62_RS17975	COG1999	signal sequence binding
GKE62_RS18000	COG0629	single-stranded DNA binding
GKE62_RS18020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GKE62_RS18025	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GKE62_RS18030	COG1218	3'(2'),5'-bisphosphate nucleotidase
GKE62_RS18040	COG0175	sulfate reduction
GKE62_RS18045	COG0604	alcohol dehydrogenase
GKE62_RS18050	COG1024	Enoyl-CoA hydratase
GKE62_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
GKE62_RS18085	COG1960	acyl-CoA dehydrogenase activity
GKE62_RS18150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GKE62_RS18155	COG1695	Transcriptional regulator
GKE62_RS18175	COG0181	hydroxymethylbilane synthase activity
GKE62_RS18180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GKE62_RS18185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GKE62_RS18210	COG0556	nucleotide-excision repair
GKE62_RS18230	COG2308	Evidence 4 Homologs of previously reported genes of
GKE62_RS18240	COG1305	Transglutaminase-like
GKE62_RS18250	COG4566	intracellular signal transduction
GKE62_RS18270	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GKE62_RS18280	COG0137	argininosuccinate synthase activity
GKE62_RS18290	COG0657	acetylesterase activity