locus-tag	class	description
C7W88_RS00195	COG0582	viral genome integration into host DNA
C7W88_RS00220	COG3447	MASE1 domain protein
C7W88_RS00220	COG5002	protein histidine kinase activity
C7W88_RS00220	COG5001	Diguanylate cyclase
C7W88_RS00230	COG1185	polyribonucleotide nucleotidyltransferase activity
C7W88_RS00235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C7W88_RS00240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C7W88_RS00255	COG1435	thymidine kinase activity
C7W88_RS00265	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C7W88_RS00275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C7W88_RS00360	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7W88_RS00385	COG4774	siderophore transport
C7W88_RS00395	COG1472	Belongs to the glycosyl hydrolase 3 family
C7W88_RS00405	COG1609	Transcriptional regulator
C7W88_RS00445	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C7W88_RS00450	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C7W88_RS00470	COG0500	methyltransferase
C7W88_RS00475	COG1063	alcohol dehydrogenase
C7W88_RS00480	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C7W88_RS00490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C7W88_RS00525	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7W88_RS00530	COG0644	oxidoreductase
C7W88_RS00535	COG2211	Major facilitator Superfamily
C7W88_RS00560	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C7W88_RS00565	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C7W88_RS00575	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C7W88_RS00610	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C7W88_RS00620	COG0156	8-amino-7-oxononanoate synthase activity
C7W88_RS00635	COG0745	RESPONSE REGULATOR receiver
C7W88_RS00640	COG2198	Histidine kinase
C7W88_RS00640	COG0643	Histidine kinase
C7W88_RS00645	COG0835	chemotaxis
C7W88_RS00650	COG0840	transmembrane signaling receptor activity
C7W88_RS00655	COG0835	chemotaxis
C7W88_RS00660	COG0840	transmembrane signaling receptor activity
C7W88_RS00665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C7W88_RS00680	COG3422	double-strand break repair
C7W88_RS00690	COG1082	Xylose isomerase domain protein TIM barrel
C7W88_RS00715	COG4964	Belongs to the GSP D family
C7W88_RS00755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C7W88_RS00770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C7W88_RS00830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C7W88_RS00835	COG0424	maF-like protein
C7W88_RS00845	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C7W88_RS00865	COG1304	FMN binding
C7W88_RS00875	COG1349	DNA-binding transcription factor activity
C7W88_RS00890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C7W88_RS00920	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C7W88_RS00930	COG4771	TonB-dependent receptor
C7W88_RS00945	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7W88_RS00980	COG1271	oxidase subunit
C7W88_RS01000	COG0617	tRNA 3'-terminal CCA addition
C7W88_RS01010	COG0484	heat shock protein binding
C7W88_RS01015	COG2885	chlorophyll binding
C7W88_RS01040	COG0824	Thioesterase
C7W88_RS01050	COG0140	phosphoribosyl-ATP diphosphatase activity
C7W88_RS01055	COG0107	imidazoleglycerol-phosphate synthase activity
C7W88_RS01060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C7W88_RS01070	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C7W88_RS01075	COG0131	Imidazoleglycerol-phosphate dehydratase
C7W88_RS01090	COG0194	GDP metabolic process
C7W88_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS01105	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS01115	COG2211	Major facilitator Superfamily
C7W88_RS01125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7W88_RS01140	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C7W88_RS01160	COG0612	Peptidase, M16
C7W88_RS01170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C7W88_RS01205	COG1702	phosphate starvation-inducible protein PhoH
C7W88_RS01210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C7W88_RS01215	COG1253	flavin adenine dinucleotide binding
C7W88_RS01280	COG2239	Acts as a magnesium transporter
C7W88_RS01305	COG1194	a g-specific adenine glycosylase
C7W88_RS01330	COG0789	Transcriptional regulator
C7W88_RS01350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C7W88_RS01355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C7W88_RS01395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C7W88_RS01400	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS01415	COG2962	Rard protein
C7W88_RS01425	COG0354	folic acid binding
C7W88_RS01445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C7W88_RS01450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7W88_RS01465	COG0314	molybdopterin synthase activity
C7W88_RS01475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C7W88_RS01480	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS01515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C7W88_RS01520	COG0109	protoheme IX farnesyltransferase activity
C7W88_RS01525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C7W88_RS01535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C7W88_RS01540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C7W88_RS01545	COG0736	holo-[acyl-carrier-protein] synthase activity
C7W88_RS01550	COG0681	Belongs to the peptidase S26 family
C7W88_RS01555	COG0628	permease
C7W88_RS01565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C7W88_RS01600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C7W88_RS01605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C7W88_RS01625	COG4771	TonB-dependent receptor
C7W88_RS01630	COG0105	UTP biosynthetic process
C7W88_RS01650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7W88_RS01660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C7W88_RS01670	COG0625	glutathione transferase activity
C7W88_RS01710	COG3436	PFAM IS66 Orf2 family protein
C7W88_RS01765	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C7W88_RS01780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C7W88_RS01850	COG0583	DNA-binding transcription factor activity
C7W88_RS01855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C7W88_RS01860	COG3002	Belongs to the UPF0753 family
C7W88_RS01865	COG3002	Belongs to the UPF0753 family
C7W88_RS01890	COG4566	intracellular signal transduction
C7W88_RS01910	COG2308	Evidence 4 Homologs of previously reported genes of
C7W88_RS01915	COG0243	molybdopterin cofactor binding
C7W88_RS01920	COG2226	methyltransferase
C7W88_RS01920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C7W88_RS01920	COG0596	Alpha beta hydrolase
C7W88_RS01930	COG0747	negative chemotaxis
C7W88_RS02015	COG1278	Cold shock
C7W88_RS02020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7W88_RS02025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C7W88_RS02040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C7W88_RS02045	COG2271	Major facilitator Superfamily
C7W88_RS02055	COG2885	chlorophyll binding
C7W88_RS02055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C7W88_RS02080	COG5425	PFAM Usg family protein
C7W88_RS02100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C7W88_RS02130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C7W88_RS02140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C7W88_RS02145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C7W88_RS02150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C7W88_RS02160	COG0668	transmembrane transport
C7W88_RS02170	COG1104	cysteine desulfurase activity
C7W88_RS02180	COG2945	thiolester hydrolase activity
C7W88_RS02195	COG0477	Major facilitator Superfamily
C7W88_RS02210	COG0640	Transcriptional regulator
C7W88_RS02220	COG0730	response to heat
C7W88_RS02255	COG0702	epimerase
C7W88_RS02295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C7W88_RS02320	COG0840	transmembrane signaling receptor activity
C7W88_RS02325	COG0432	Pfam Uncharacterised protein family UPF0047
C7W88_RS02330	COG3659	wide pore channel activity
C7W88_RS02335	COG0840	transmembrane signaling receptor activity
C7W88_RS02350	COG3023	N-Acetylmuramoyl-L-alanine amidase
C7W88_RS02365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7W88_RS02370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C7W88_RS02375	COG0740	serine-type endopeptidase activity
C7W88_RS02385	COG1525	nuclease
C7W88_RS02390	COG0544	peptidyl-prolyl cis-trans isomerase activity
C7W88_RS02410	COG0616	signal peptide processing
C7W88_RS02420	COG0540	Belongs to the ATCase OTCase family
C7W88_RS02425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C7W88_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS02530	COG4786	Flagellar basal body rod
C7W88_RS02540	COG4786	Flagellar basal body rod
C7W88_RS02550	COG1706	bacterial-type flagellum-dependent cell motility
C7W88_RS02575	COG1360	Flagellar Motor Protein
C7W88_RS02580	COG1404	Belongs to the peptidase S8 family
C7W88_RS02585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7W88_RS02655	COG1987	bacterial-type flagellum assembly
C7W88_RS02660	COG4791	protein targeting
C7W88_RS02680	COG2201	protein-glutamate methylesterase activity
C7W88_RS02690	COG2198	Histidine kinase
C7W88_RS02690	COG0643	Histidine kinase
C7W88_RS02695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C7W88_RS02705	COG0745	RESPONSE REGULATOR receiver
C7W88_RS02710	COG0835	chemotaxis
C7W88_RS02745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C7W88_RS02750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C7W88_RS02765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7W88_RS02770	COG2833	Protein of unknown function (DUF455)
C7W88_RS02775	COG0739	heme binding
C7W88_RS02825	COG0556	nucleotide-excision repair
C7W88_RS02830	COG3657	addiction module killer protein
C7W88_RS02835	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7W88_RS02845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C7W88_RS02845	COG3743	rRNA binding
C7W88_RS02855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C7W88_RS02860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C7W88_RS02865	COG0181	hydroxymethylbilane synthase activity
C7W88_RS02885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7W88_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS02920	COG0776	regulation of translation
C7W88_RS02950	COG4221	oxidoreductase activity
C7W88_RS03015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C7W88_RS03095	COG1309	transcriptional regulator
C7W88_RS03120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7W88_RS03125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7W88_RS03130	COG0625	glutathione transferase activity
C7W88_RS03135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C7W88_RS03140	COG0706	membrane insertase activity
C7W88_RS03145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C7W88_RS03150	COG0594	ribonuclease P activity
C7W88_RS03155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C7W88_RS03160	COG3920	Histidine kinase
C7W88_RS03165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C7W88_RS03175	COG0589	response to stress
C7W88_RS03180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C7W88_RS03185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C7W88_RS03215	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C7W88_RS03240	COG2814	Major facilitator Superfamily
C7W88_RS03245	COG3300	MHYT domain
C7W88_RS03245	COG5001	Diguanylate cyclase
C7W88_RS03250	COG0583	DNA-binding transcription factor activity
C7W88_RS03255	COG2967	ApaG domain
C7W88_RS03260	COG1381	Involved in DNA repair and RecF pathway recombination
C7W88_RS03265	COG0473	3-isopropylmalate dehydrogenase activity
C7W88_RS03305	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7W88_RS03310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C7W88_RS03320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C7W88_RS03325	COG3746	phosphate-selective porin O and P
C7W88_RS03330	COG3746	phosphate-selective porin O and P
C7W88_RS03340	COG1648	precorrin-2 dehydrogenase activity
C7W88_RS03340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7W88_RS03345	COG0019	diaminopimelate decarboxylase activity
C7W88_RS03355	COG0165	Argininosuccinate lyase
C7W88_RS03370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7W88_RS03375	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C7W88_RS03390	COG1482	cell wall glycoprotein biosynthetic process
C7W88_RS03405	COG0438	transferase activity, transferring glycosyl groups
C7W88_RS03445	COG3850	Histidine kinase
C7W88_RS03445	COG5002	protein histidine kinase activity
C7W88_RS03455	COG0433	COG0433 Predicted ATPase
C7W88_RS03470	COG0564	pseudouridine synthase activity
C7W88_RS03480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C7W88_RS03495	COG0673	inositol 2-dehydrogenase activity
C7W88_RS03505	COG4774	siderophore transport
C7W88_RS03535	COG0386	Belongs to the glutathione peroxidase family
C7W88_RS03555	COG0583	DNA-binding transcription factor activity
C7W88_RS03580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C7W88_RS03585	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS03590	COG0252	asparaginase activity
C7W88_RS03615	COG0583	DNA-binding transcription factor activity
C7W88_RS03635	COG0745	RESPONSE REGULATOR receiver
C7W88_RS03640	COG2205	protein histidine kinase activity
C7W88_RS03665	COG0436	Aminotransferase
C7W88_RS03670	COG3243	poly(R)-hydroxyalkanoic acid synthase
C7W88_RS03700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C7W88_RS03720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7W88_RS03730	COG0784	Response regulator, receiver
C7W88_RS03750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C7W88_RS03755	COG1301	dicarboxylic acid transport
C7W88_RS03760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C7W88_RS03765	COG3813	Protein conserved in bacteria
C7W88_RS03770	COG0351	phosphomethylpyrimidine kinase
C7W88_RS03770	COG0352	thiamine-phosphate diphosphorylase activity
C7W88_RS03775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7W88_RS03805	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7W88_RS03820	COG3474	cytochrome
C7W88_RS03840	COG0714	Associated with various cellular activities
C7W88_RS03860	COG0454	-acetyltransferase
C7W88_RS03870	COG2086	electron transfer activity
C7W88_RS03875	COG0045	succinate-CoA ligase (ADP-forming) activity
C7W88_RS03885	COG0667	Aldo Keto reductase
C7W88_RS03890	COG2885	chlorophyll binding
C7W88_RS03895	COG1253	flavin adenine dinucleotide binding
C7W88_RS03905	COG0067	glutamate synthase
C7W88_RS03905	COG0069	glutamate synthase activity
C7W88_RS03905	COG0070	glutamate synthase
C7W88_RS03915	COG0438	transferase activity, transferring glycosyl groups
C7W88_RS03930	COG1215	transferase activity, transferring glycosyl groups
C7W88_RS03940	COG1132	(ABC) transporter
C7W88_RS03945	COG1968	undecaprenyl-diphosphatase activity
C7W88_RS03965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C7W88_RS03975	COG3093	addiction module antidote protein HigA
C7W88_RS04030	COG0175	sulfate reduction
C7W88_RS04045	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C7W88_RS04060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C7W88_RS04075	COG0196	riboflavin kinase activity
C7W88_RS04085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C7W88_RS04095	COG0588	phosphoglycerate mutase activity
C7W88_RS04160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C7W88_RS04185	COG2866	Carboxypeptidase
C7W88_RS04205	COG4774	siderophore transport
C7W88_RS04215	COG0235	Class ii aldolase
C7W88_RS04235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C7W88_RS04240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C7W88_RS04250	COG1612	heme a metabolic process
C7W88_RS04260	COG2022	thiamine diphosphate biosynthetic process
C7W88_RS04265	COG0280	phosphate acetyltransferase
C7W88_RS04265	COG0281	malic enzyme
C7W88_RS04275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C7W88_RS04285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C7W88_RS04295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C7W88_RS04310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7W88_RS04320	COG2095	MarC family integral membrane protein
C7W88_RS04325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C7W88_RS04330	COG3118	belongs to the thioredoxin family
C7W88_RS04395	COG1999	signal sequence binding
C7W88_RS04425	COG3177	Filamentation induced by cAMP protein fic
C7W88_RS04445	COG1476	TRANSCRIPTIONal
C7W88_RS04485	COG0741	lytic transglycosylase activity
C7W88_RS04515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7W88_RS04520	COG1205	dead DEAH box helicase
C7W88_RS04520	COG1111	helicase
C7W88_RS04540	COG1401	restriction endodeoxyribonuclease activity
C7W88_RS04545	COG1401	restriction endodeoxyribonuclease activity
C7W88_RS04595	COG4962	Type ii secretion system protein e
C7W88_RS04630	COG3701	Conjugal transfer protein
C7W88_RS04640	COG2948	multi-organism process
C7W88_RS04665	COG0450	alkyl hydroperoxide reductase
C7W88_RS04670	COG1136	(ABC) transporter
C7W88_RS04715	COG0450	alkyl hydroperoxide reductase
C7W88_RS04730	COG4988	ABC transporter
C7W88_RS04740	COG1294	oxidase, subunit
C7W88_RS04760	COG0662	Cupin 2, conserved barrel domain protein
C7W88_RS04875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C7W88_RS04900	COG2119	membrane
C7W88_RS04920	COG0513	Belongs to the DEAD box helicase family
C7W88_RS04935	COG2814	Major facilitator Superfamily
C7W88_RS04970	COG3279	Response regulator of the LytR AlgR family
C7W88_RS04990	COG0590	tRNA wobble adenosine to inosine editing
C7W88_RS04995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C7W88_RS05005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7W88_RS05025	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C7W88_RS05035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C7W88_RS05040	COG4149	molybdate abc transporter
C7W88_RS05045	COG0725	ABC transporter, periplasmic molybdate-binding protein
C7W88_RS05060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7W88_RS05085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C7W88_RS05100	COG0316	Belongs to the HesB IscA family
C7W88_RS05110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C7W88_RS05115	COG0719	Fe-S assembly protein
C7W88_RS05120	COG0396	ATPase activity
C7W88_RS05135	COG0719	Fe-S assembly protein
C7W88_RS05140	COG1959	2 iron, 2 sulfur cluster binding
C7W88_RS05145	COG0167	dihydroorotate dehydrogenase activity
C7W88_RS05150	COG0405	Gamma-glutamyltransferase
C7W88_RS05165	COG2972	Histidine kinase
C7W88_RS05190	COG0823	Involved in the tonB-independent uptake of proteins
C7W88_RS05190	COG1506	peptidase
C7W88_RS05200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C7W88_RS05225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7W88_RS05240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS05250	COG0151	Belongs to the GarS family
C7W88_RS05255	COG1570	exodeoxyribonuclease VII activity
C7W88_RS05265	COG4942	peptidase
C7W88_RS05285	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C7W88_RS05300	COG0776	regulation of translation
C7W88_RS05305	COG2188	Transcriptional regulator
C7W88_RS05310	COG3104	oligopeptide transport
C7W88_RS05320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C7W88_RS05335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7W88_RS05345	COG0316	Belongs to the HesB IscA family
C7W88_RS05360	COG0006	proline dipeptidase activity
C7W88_RS05370	COG2268	Band 7 protein
C7W88_RS05375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C7W88_RS05385	COG1959	2 iron, 2 sulfur cluster binding
C7W88_RS05400	COG0717	Belongs to the dCTP deaminase family
C7W88_RS05405	COG0295	cytidine deaminase activity
C7W88_RS05415	COG5328	Belongs to the UPF0262 family
C7W88_RS05420	COG0305	Participates in initiation and elongation during chromosome replication
C7W88_RS05425	COG1758	RNA polymerase activity
C7W88_RS05445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C7W88_RS05450	COG0445	tRNA wobble uridine modification
C7W88_RS05455	COG0357	Ribosomal RNA small subunit methyltransferase G
C7W88_RS05480	COG1956	GAF domain-containing protein
C7W88_RS05495	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS05500	COG0009	L-threonylcarbamoyladenylate synthase
C7W88_RS05520	COG1329	Transcriptional regulator
C7W88_RS05525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C7W88_RS05530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7W88_RS05540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C7W88_RS05545	COG1981	membrane
C7W88_RS05550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C7W88_RS05555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C7W88_RS05560	COG0424	maF-like protein
C7W88_RS05565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7W88_RS05570	COG0237	dephospho-CoA kinase activity
C7W88_RS05575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C7W88_RS05580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C7W88_RS05585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7W88_RS05605	COG0138	bifunctional purine biosynthesis protein purh
C7W88_RS05625	COG1213	nucleotidyl transferase
C7W88_RS05630	COG1260	myo-inositol-1-phosphate synthase
C7W88_RS05635	COG0546	phosphoglycolate phosphatase activity
C7W88_RS05675	COG0321	lipoyl(octanoyl) transferase activity
C7W88_RS05690	COG1902	pentaerythritol trinitrate reductase activity
C7W88_RS05700	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C7W88_RS05750	COG0037	tRNA processing
C7W88_RS05765	COG0739	heme binding
C7W88_RS05775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C7W88_RS05780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C7W88_RS05785	COG1872	DUF167
C7W88_RS05830	COG0604	alcohol dehydrogenase
C7W88_RS05830	COG3321	synthase
C7W88_RS05830	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS05850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C7W88_RS05865	COG0799	negative regulation of ribosome biogenesis
C7W88_RS05880	COG0793	Belongs to the peptidase S41A family
C7W88_RS05890	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C7W88_RS05900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C7W88_RS05905	COG1295	ribonuclease BN
C7W88_RS05915	COG0259	pyridoxamine-phosphate oxidase activity
C7W88_RS05940	COG0482	sulfurtransferase activity
C7W88_RS05965	COG2733	membrane
C7W88_RS05975	COG0784	Response regulator, receiver
C7W88_RS05975	COG4191	Histidine kinase
C7W88_RS05980	COG0459	protein refolding
C7W88_RS05985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C7W88_RS05990	COG0534	Mate efflux family protein
C7W88_RS06005	COG0222	ribosome binding
C7W88_RS06010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C7W88_RS06015	COG3655	Transcriptional regulator
C7W88_RS06030	COG0085	RNA polymerase activity
C7W88_RS06040	COG0840	transmembrane signaling receptor activity
C7W88_RS06045	COG1494	fructose-1,6-bisphosphatase
C7W88_RS06085	COG1393	Belongs to the ArsC family
C7W88_RS06095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C7W88_RS06100	COG1301	dicarboxylic acid transport
C7W88_RS06110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C7W88_RS06115	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C7W88_RS06120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C7W88_RS06140	COG0527	aspartate kinase activity
C7W88_RS06175	COG1201	RNA secondary structure unwinding
C7W88_RS06190	COG0443	Heat shock 70 kDa protein
C7W88_RS06210	COG1192	Involved in chromosome partitioning
C7W88_RS06215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C7W88_RS06265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C7W88_RS06290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C7W88_RS06295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C7W88_RS06315	COG0534	Mate efflux family protein
C7W88_RS06330	COG0730	response to heat
C7W88_RS06335	COG1215	transferase activity, transferring glycosyl groups
C7W88_RS06340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C7W88_RS06345	COG0783	Belongs to the Dps family
C7W88_RS06455	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7W88_RS06470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7W88_RS06480	COG0456	acetyltransferase
C7W88_RS06495	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C7W88_RS06500	COG1678	Uncharacterized ACR, COG1678
C7W88_RS06520	COG0489	protein tyrosine kinase activity
C7W88_RS06525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7W88_RS06525	COG2010	Cytochrome c
C7W88_RS06530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C7W88_RS06540	COG0268	Binds directly to 16S ribosomal RNA
C7W88_RS06545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C7W88_RS06590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C7W88_RS06605	COG0312	modulator of DNA gyrase
C7W88_RS06615	COG1131	(ABC) transporter
C7W88_RS06635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C7W88_RS06660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7W88_RS06665	COG0356	it plays a direct role in the translocation of protons across the membrane
C7W88_RS06675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C7W88_RS06680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C7W88_RS06685	COG1137	ATPase activity
C7W88_RS06695	COG0312	modulator of DNA gyrase
C7W88_RS06700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C7W88_RS06715	COG0124	histidyl-tRNA synthetase
C7W88_RS06720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C7W88_RS06725	COG2890	protein-(glutamine-N5) methyltransferase activity
C7W88_RS06735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C7W88_RS06740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C7W88_RS06775	COG0606	chelatase, subunit chli
C7W88_RS06785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7W88_RS06785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7W88_RS06805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C7W88_RS06805	COG1372	Participates in initiation and elongation during chromosome replication
C7W88_RS06815	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
C7W88_RS06820	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
C7W88_RS06845	COG2255	four-way junction helicase activity
C7W88_RS06855	COG0590	tRNA wobble adenosine to inosine editing
C7W88_RS06860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C7W88_RS06870	COG0217	transcriptional regulatory protein
C7W88_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS06895	COG0469	pyruvate kinase activity
C7W88_RS06900	COG4774	siderophore transport
C7W88_RS06900	COG1629	transport
C7W88_RS06905	COG3706	GGDEF domain
C7W88_RS06910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C7W88_RS06930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C7W88_RS06940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C7W88_RS06945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C7W88_RS06960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7W88_RS06980	COG1309	transcriptional regulator
C7W88_RS07000	COG2884	Cell division ATP-binding protein ftsE
C7W88_RS07025	COG0287	Prephenate dehydrogenase
C7W88_RS07030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C7W88_RS07035	COG0004	ammonium transporteR
C7W88_RS07040	COG0347	Belongs to the P(II) protein family
C7W88_RS07050	COG0596	Alpha beta hydrolase
C7W88_RS07055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C7W88_RS07070	COG0072	phenylalanine-tRNA ligase activity
C7W88_RS07075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C7W88_RS07085	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C7W88_RS07090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C7W88_RS07105	COG2193	ferroxidase activity
C7W88_RS07110	COG5265	(ABC) transporter
C7W88_RS07125	COG1216	Glycosyl transferase, family 2
C7W88_RS07225	COG3436	PFAM IS66 Orf2 family protein
C7W88_RS07235	COG5001	Diguanylate cyclase
C7W88_RS07260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C7W88_RS07290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C7W88_RS07315	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C7W88_RS07325	COG0180	Tryptophanyl-tRNA synthetase
C7W88_RS07370	COG1276	copper resistance
C7W88_RS07380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C7W88_RS07385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7W88_RS07390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7W88_RS07395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C7W88_RS07410	COG0596	Alpha beta hydrolase
C7W88_RS07420	COG0840	transmembrane signaling receptor activity
C7W88_RS07430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C7W88_RS07435	COG1741	Belongs to the pirin family
C7W88_RS07455	COG3023	N-Acetylmuramoyl-L-alanine amidase
C7W88_RS07460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C7W88_RS07465	COG0745	RESPONSE REGULATOR receiver
C7W88_RS07470	COG0642	Histidine kinase
C7W88_RS07475	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C7W88_RS07480	COG1660	Displays ATPase and GTPase activities
C7W88_RS07485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C7W88_RS07495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7W88_RS07510	COG1322	Protein conserved in bacteria
C7W88_RS07520	COG0242	peptide deformylase activity
C7W88_RS07525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C7W88_RS07530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C7W88_RS07535	COG0101	tRNA pseudouridine synthase activity
C7W88_RS07545	COG3300	MHYT domain
C7W88_RS07545	COG5001	Diguanylate cyclase
C7W88_RS07555	COG0625	glutathione transferase activity
C7W88_RS07560	COG1309	transcriptional regulator
C7W88_RS07565	COG5507	3-demethylubiquinone-9 3-methyltransferase
C7W88_RS07590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7W88_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS07665	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS07720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7W88_RS07725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C7W88_RS07740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7W88_RS07740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C7W88_RS07755	COG2983	Belongs to the UPF0260 family
C7W88_RS07760	COG1999	signal sequence binding
C7W88_RS07800	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C7W88_RS07830	COG0546	phosphoglycolate phosphatase activity
C7W88_RS07840	COG0564	pseudouridine synthase activity
C7W88_RS07845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C7W88_RS07850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C7W88_RS07855	COG0545	Peptidyl-prolyl cis-trans isomerase
C7W88_RS07860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7W88_RS07875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C7W88_RS07900	COG0612	Peptidase, M16
C7W88_RS07920	COG0564	pseudouridine synthase activity
C7W88_RS07925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7W88_RS07955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C7W88_RS07995	COG0457	Tetratricopeptide repeat
C7W88_RS08070	COG0546	phosphoglycolate phosphatase activity
C7W88_RS08075	COG0028	Belongs to the TPP enzyme family
C7W88_RS08095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7W88_RS08125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C7W88_RS08150	COG0659	secondary active sulfate transmembrane transporter activity
C7W88_RS08165	COG4771	TonB-dependent receptor
C7W88_RS08190	COG1448	Aminotransferase
C7W88_RS08230	COG2814	Major facilitator Superfamily
C7W88_RS08250	COG2814	Major facilitator Superfamily
C7W88_RS08270	COG1396	sequence-specific DNA binding
C7W88_RS08270	COG3800	Transcriptional regulator
C7W88_RS08275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7W88_RS08280	COG0183	Belongs to the thiolase family
C7W88_RS08285	COG0346	lactoylglutathione lyase activity
C7W88_RS08290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7W88_RS08290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C7W88_RS08300	COG4770	biotin carboxylase activity
C7W88_RS08305	COG0277	FAD linked oxidase domain protein
C7W88_RS08310	COG3474	cytochrome
C7W88_RS08315	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C7W88_RS08325	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS08350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C7W88_RS08365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C7W88_RS08375	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C7W88_RS08380	COG0081	regulation of translation
C7W88_RS08390	COG0745	RESPONSE REGULATOR receiver
C7W88_RS08400	COG5002	protein histidine kinase activity
C7W88_RS08405	COG3161	chorismate lyase activity
C7W88_RS08410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C7W88_RS08415	COG1058	Belongs to the CinA family
C7W88_RS08415	COG1546	Belongs to the CinA family
C7W88_RS08425	COG0598	Magnesium transport protein CorA
C7W88_RS08430	COG1392	Phosphate transport regulator
C7W88_RS08435	COG0306	phosphate transporter
C7W88_RS08450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7W88_RS08510	COG0583	DNA-binding transcription factor activity
C7W88_RS08540	COG1024	Enoyl-CoA hydratase
C7W88_RS08555	COG1160	GTP binding
C7W88_RS08575	COG0183	Belongs to the thiolase family
C7W88_RS08585	COG1250	3-hydroxyacyl-CoA dehydrogenase
C7W88_RS08585	COG1024	Enoyl-CoA hydratase
C7W88_RS08605	COG0583	DNA-binding transcription factor activity
C7W88_RS08610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7W88_RS08650	COG1970	mechanosensitive ion channel activity
C7W88_RS08665	COG3724	N-succinylarginine dihydrolase activity
C7W88_RS08680	COG0693	protein deglycase activity
C7W88_RS08720	COG4566	intracellular signal transduction
C7W88_RS08725	COG0302	gtp cyclohydrolase
C7W88_RS08730	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C7W88_RS08755	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS08760	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS08765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS08770	COG0183	Belongs to the thiolase family
C7W88_RS08775	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS08835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C7W88_RS08840	COG0049	tRNA binding
C7W88_RS08845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C7W88_RS08855	COG0051	transcription antitermination factor activity, RNA binding
C7W88_RS08860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C7W88_RS08865	COG0088	Forms part of the polypeptide exit tunnel
C7W88_RS08870	COG0089	rRNA binding
C7W88_RS08875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C7W88_RS08880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C7W88_RS08885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C7W88_RS08890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C7W88_RS08895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C7W88_RS08900	COG0255	Belongs to the universal ribosomal protein uL29 family
C7W88_RS08905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C7W88_RS08910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C7W88_RS08915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C7W88_RS08920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C7W88_RS08925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C7W88_RS08930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C7W88_RS08935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C7W88_RS08940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C7W88_RS08945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C7W88_RS08950	COG1841	ribosomal large subunit assembly
C7W88_RS08955	COG0200	Binds to the 23S rRNA
C7W88_RS08960	COG0201	protein transport
C7W88_RS08965	COG0563	adenylate kinase activity
C7W88_RS08975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C7W88_RS08990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C7W88_RS09000	COG4106	trans-aconitate 2-methyltransferase activity
C7W88_RS09005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C7W88_RS09015	COG0538	isocitrate dehydrogenase activity
C7W88_RS09020	COG1024	Enoyl-CoA hydratase
C7W88_RS09075	COG0477	Major facilitator Superfamily
C7W88_RS09080	COG0742	ribosomal rna small subunit methyltransferase
C7W88_RS09085	COG1187	pseudouridine synthase activity
C7W88_RS09095	COG0285	dihydrofolate synthase activity
C7W88_RS09100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C7W88_RS09105	COG0159	tryptophan synthase activity
C7W88_RS09110	COG2852	Protein conserved in bacteria
C7W88_RS09115	COG0133	tryptophan synthase activity
C7W88_RS09145	COG0284	orotidine-5'-phosphate decarboxylase activity
C7W88_RS09155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C7W88_RS09165	COG2003	Belongs to the UPF0758 family
C7W88_RS09200	COG0356	it plays a direct role in the translocation of protons across the membrane
C7W88_RS09205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7W88_RS09210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7W88_RS09215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C7W88_RS09225	COG1609	Transcriptional regulator
C7W88_RS09230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7W88_RS09235	COG0539	negative regulation of cytoplasmic translation
C7W88_RS09240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C7W88_RS09245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C7W88_RS09255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C7W88_RS09310	COG2059	Chromate
C7W88_RS09315	COG0583	DNA-binding transcription factor activity
C7W88_RS09325	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C7W88_RS09330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C7W88_RS09335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C7W88_RS09340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C7W88_RS09350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C7W88_RS09375	COG1942	4-Oxalocrotonate Tautomerase
C7W88_RS09390	COG0583	DNA-binding transcription factor activity
C7W88_RS09400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C7W88_RS09405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7W88_RS09405	COG2010	Cytochrome c
C7W88_RS09410	COG2080	2 iron, 2 sulfur cluster binding
C7W88_RS09415	COG0667	Aldo Keto reductase
C7W88_RS09430	COG0366	Alpha amylase catalytic
C7W88_RS09465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C7W88_RS09505	COG0657	acetylesterase activity
C7W88_RS09530	COG4206	TonB-dependent receptor
C7W88_RS09535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C7W88_RS09540	COG0328	RNA-DNA hybrid ribonuclease activity
C7W88_RS09545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7W88_RS09550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C7W88_RS09560	COG0018	arginyl-trna synthetase
C7W88_RS09575	COG1309	transcriptional regulator
C7W88_RS09580	COG1472	Belongs to the glycosyl hydrolase 3 family
C7W88_RS09590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C7W88_RS09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7W88_RS09600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C7W88_RS09605	COG0805	protein transport
C7W88_RS09615	COG2084	Dehydrogenase
C7W88_RS09625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C7W88_RS09635	COG0729	surface antigen
C7W88_RS09655	COG5001	Diguanylate cyclase
C7W88_RS09670	COG0174	glutamine synthetase
C7W88_RS09675	COG0347	Belongs to the P(II) protein family
C7W88_RS09680	COG0024	Methionine aminopeptidase
C7W88_RS09690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C7W88_RS09705	COG4771	TonB-dependent receptor
C7W88_RS09730	COG2154	pterin-4-alpha-carbinolamine dehydratase
C7W88_RS09735	COG4133	protoheme IX ABC transporter activity
C7W88_RS09740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C7W88_RS09745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C7W88_RS09765	COG0275	rRNA processing
C7W88_RS09780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C7W88_RS09785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C7W88_RS09790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C7W88_RS09795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C7W88_RS09805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7W88_RS09810	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7W88_RS09815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C7W88_RS09820	COG1181	Belongs to the D-alanine--D-alanine ligase family
C7W88_RS09825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C7W88_RS09830	COG0849	cell division
C7W88_RS09875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C7W88_RS09885	COG0702	epimerase
C7W88_RS09895	COG3152	Membrane
C7W88_RS09910	COG4181	ATPase activity
C7W88_RS09925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C7W88_RS09935	COG1842	Phage shock protein A
C7W88_RS09975	COG2166	iron-sulfur cluster assembly
C7W88_RS09985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7W88_RS10010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7W88_RS10035	COG0066	3-isopropylmalate dehydratase activity
C7W88_RS10065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7W88_RS10070	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7W88_RS10075	COG0567	Dehydrogenase, E1 component
C7W88_RS10085	COG0039	L-malate dehydrogenase activity
C7W88_RS10100	COG4206	TonB-dependent receptor
C7W88_RS10115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C7W88_RS10140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C7W88_RS10190	COG2205	protein histidine kinase activity
C7W88_RS10200	COG1522	sequence-specific DNA binding
C7W88_RS10205	COG0287	Prephenate dehydrogenase
C7W88_RS10205	COG1605	Chorismate mutase
C7W88_RS10210	COG0142	geranyltranstransferase activity
C7W88_RS10215	COG0667	Aldo Keto reductase
C7W88_RS10245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C7W88_RS10250	COG2853	Lipoprotein
C7W88_RS10265	COG0776	regulation of translation
C7W88_RS10275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C7W88_RS10290	COG0688	phosphatidylethanolamine metabolic process
C7W88_RS10305	COG0052	Belongs to the universal ribosomal protein uS2 family
C7W88_RS10310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C7W88_RS10315	COG0528	UMP kinase activity
C7W88_RS10320	COG0233	cytoplasmic translational termination
C7W88_RS10325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C7W88_RS10330	COG0575	Belongs to the CDS family
C7W88_RS10335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C7W88_RS10340	COG0750	zinc metalloprotease
C7W88_RS10345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C7W88_RS10355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C7W88_RS10360	COG0254	rRNA binding
C7W88_RS10405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C7W88_RS10410	COG1138	Cytochrome C-type biogenesis protein
C7W88_RS10420	COG3088	subunit of a heme lyase
C7W88_RS10435	COG2202	Pas domain
C7W88_RS10435	COG3920	Histidine kinase
C7W88_RS10440	COG0745	RESPONSE REGULATOR receiver
C7W88_RS10455	COG2917	probably involved in intracellular septation
C7W88_RS10460	COG0552	protein localization to endoplasmic reticulum
C7W88_RS10465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C7W88_RS10475	COG3300	MHYT domain
C7W88_RS10475	COG5001	Diguanylate cyclase
C7W88_RS10480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C7W88_RS10485	COG0228	four-way junction DNA binding
C7W88_RS10490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C7W88_RS10515	COG0335	large ribosomal subunit rRNA binding
C7W88_RS10525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C7W88_RS10530	COG2267	carboxylic ester hydrolase activity
C7W88_RS10540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C7W88_RS10550	COG0359	binds to the 23S rRNA
C7W88_RS10555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C7W88_RS10560	COG0360	Binds together with S18 to 16S ribosomal RNA
C7W88_RS10565	COG1024	Enoyl-CoA hydratase
C7W88_RS10580	COG2354	Protein conserved in bacteria
C7W88_RS10595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C7W88_RS10605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C7W88_RS10620	COG0840	transmembrane signaling receptor activity
C7W88_RS10630	COG0493	'glutamate synthase
C7W88_RS10640	COG3300	MHYT domain
C7W88_RS10640	COG5001	Diguanylate cyclase
C7W88_RS10685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C7W88_RS10690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C7W88_RS10715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C7W88_RS10720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C7W88_RS10730	COG2211	Major facilitator Superfamily
C7W88_RS10740	COG4771	TonB-dependent receptor
C7W88_RS10745	COG1082	Xylose isomerase domain protein TIM barrel
C7W88_RS10770	COG4771	TonB-dependent receptor
C7W88_RS10775	COG2211	Major facilitator Superfamily
C7W88_RS10805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C7W88_RS10810	COG1522	sequence-specific DNA binding
C7W88_RS10825	COG4638	Rieske (2fe-2S)
C7W88_RS10830	COG1053	succinate dehydrogenase
C7W88_RS10870	COG0864	Transcriptional regulator
C7W88_RS10875	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C7W88_RS10900	COG0745	RESPONSE REGULATOR receiver
C7W88_RS10905	COG3850	Histidine kinase
C7W88_RS10905	COG5002	protein histidine kinase activity
C7W88_RS10950	COG2030	dehydratase
C7W88_RS10965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C7W88_RS10975	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS10980	COG0583	DNA-binding transcription factor activity
C7W88_RS11010	COG0033	Phosphoglucomutase
C7W88_RS11020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C7W88_RS11025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C7W88_RS11030	COG0058	SHG alpha-glucan phosphorylase activity
C7W88_RS11035	COG3038	cytochrome b561
C7W88_RS11045	COG0784	Response regulator, receiver
C7W88_RS11045	COG2198	Histidine kinase
C7W88_RS11045	COG2205	protein histidine kinase activity
C7W88_RS11050	COG0745	RESPONSE REGULATOR receiver
C7W88_RS11060	COG4221	oxidoreductase activity
C7W88_RS11060	COG3321	synthase
C7W88_RS11060	COG0604	alcohol dehydrogenase
C7W88_RS11060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C7W88_RS11065	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS11070	COG1024	Enoyl-CoA hydratase
C7W88_RS11075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C7W88_RS11095	COG0531	amino acid
C7W88_RS11100	COG0457	Tetratricopeptide repeat
C7W88_RS11135	COG1522	sequence-specific DNA binding
C7W88_RS11140	COG1309	transcriptional regulator
C7W88_RS11145	COG3391	amine dehydrogenase activity
C7W88_RS11180	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS11185	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS11245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C7W88_RS11270	COG0457	Tetratricopeptide repeat
C7W88_RS11280	COG5002	protein histidine kinase activity
C7W88_RS11280	COG2198	Histidine kinase
C7W88_RS11280	COG0784	Response regulator, receiver
C7W88_RS11305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C7W88_RS11335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7W88_RS11390	COG3038	cytochrome b561
C7W88_RS11420	COG0450	alkyl hydroperoxide reductase
C7W88_RS11450	COG3474	cytochrome
C7W88_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS11455	COG3347	Dehydrogenase
C7W88_RS11465	COG3940	Belongs to the glycosyl hydrolase 43 family
C7W88_RS11470	COG1609	Transcriptional regulator
C7W88_RS11475	COG1472	Belongs to the glycosyl hydrolase 3 family
C7W88_RS11500	COG0438	transferase activity, transferring glycosyl groups
C7W88_RS11520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7W88_RS11525	COG1546	Belongs to the CinA family
C7W88_RS11525	COG1058	Belongs to the CinA family
C7W88_RS11530	COG1024	Enoyl-CoA hydratase
C7W88_RS11535	COG2264	protein methyltransferase activity
C7W88_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS11590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C7W88_RS11590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C7W88_RS11600	COG1051	belongs to the nudix hydrolase family
C7W88_RS11605	COG0657	acetylesterase activity
C7W88_RS11615	COG1013	pyruvate-flavodoxin oxidoreductase activity
C7W88_RS11625	COG0671	phosphoesterase, PA-phosphatase related
C7W88_RS11630	COG0415	Belongs to the DNA photolyase family
C7W88_RS11635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7W88_RS11645	COG4221	oxidoreductase activity
C7W88_RS11650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C7W88_RS11665	COG1136	(ABC) transporter
C7W88_RS11680	COG0386	Belongs to the glutathione peroxidase family
C7W88_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS11720	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C7W88_RS11720	COG0644	oxidoreductase
C7W88_RS11725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C7W88_RS11735	COG0129	dihydroxy-acid dehydratase activity
C7W88_RS11770	COG1748	Saccharopine dehydrogenase
C7W88_RS11800	COG0156	8-amino-7-oxononanoate synthase activity
C7W88_RS11810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C7W88_RS11815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C7W88_RS11820	COG0758	DNA mediated transformation
C7W88_RS11820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C7W88_RS11825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C7W88_RS11825	COG1754	DNA topoisomerase type I activity
C7W88_RS11840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C7W88_RS11850	COG0681	Belongs to the peptidase S26 family
C7W88_RS11855	COG0166	Belongs to the GPI family
C7W88_RS11870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C7W88_RS11920	COG4773	Receptor
C7W88_RS11930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C7W88_RS11950	COG1278	Cold shock
C7W88_RS11980	COG2824	Alkylphosphonate utilization operon protein PhnA
C7W88_RS12010	COG2171	N-acyltransferase activity
C7W88_RS12015	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
C7W88_RS12040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C7W88_RS12095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C7W88_RS12110	COG0509	glycine decarboxylation via glycine cleavage system
C7W88_RS12115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7W88_RS12120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C7W88_RS12125	COG0697	spore germination
C7W88_RS12160	COG0463	Glycosyl transferase, family 2
C7W88_RS12190	COG0511	ligase activity, forming carbon-carbon bonds
C7W88_RS12215	COG2271	Major facilitator Superfamily
C7W88_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS12265	COG2211	Major facilitator Superfamily
C7W88_RS12280	COG1621	beta-fructofuranosidase activity
C7W88_RS12305	COG1621	beta-fructofuranosidase activity
C7W88_RS12340	COG0366	Alpha amylase catalytic
C7W88_RS12350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C7W88_RS12360	COG0129	dihydroxy-acid dehydratase activity
C7W88_RS12380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C7W88_RS12385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C7W88_RS12395	COG4974	Belongs to the 'phage' integrase family
C7W88_RS12400	COG0825	malonyl-CoA metabolic process
C7W88_RS12435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7W88_RS12440	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7W88_RS12440	COG0022	dehydrogenase e1 component
C7W88_RS12485	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C7W88_RS12495	COG0134	indole-3-glycerol-phosphate synthase activity
C7W88_RS12500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C7W88_RS12540	COG0071	Belongs to the small heat shock protein (HSP20) family
C7W88_RS12545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7W88_RS12550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C7W88_RS12580	COG0302	gtp cyclohydrolase
C7W88_RS12595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C7W88_RS12595	COG0678	peroxiredoxin activity
C7W88_RS12600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C7W88_RS12610	COG0802	atpase or kinase
C7W88_RS12615	COG3178	'Phosphotransferase
C7W88_RS12620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C7W88_RS12645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C7W88_RS12655	COG0653	protein targeting
C7W88_RS12700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C7W88_RS12710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C7W88_RS12725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C7W88_RS12790	COG3179	chitinase
C7W88_RS12935	COG1783	phage Terminase large subunit
C7W88_RS12940	COG5484	DNA packaging
C7W88_RS12940	COG3728	DNA packaging
C7W88_RS12975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C7W88_RS12980	COG1061	Type III restriction enzyme res subunit
C7W88_RS13010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C7W88_RS13090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C7W88_RS13145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C7W88_RS13165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C7W88_RS13175	COG0126	phosphoglycerate kinase activity
C7W88_RS13180	COG3588	fructose-bisphosphate aldolase
C7W88_RS13190	COG0352	thiamine-phosphate diphosphorylase activity
C7W88_RS13200	COG1297	OPT oligopeptide transporter protein
C7W88_RS13210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C7W88_RS13215	COG0483	inositol monophosphate 1-phosphatase activity
C7W88_RS13250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C7W88_RS13260	COG0442	prolyl-tRNA aminoacylation
C7W88_RS13270	COG0557	exoribonuclease II activity
C7W88_RS13280	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7W88_RS13285	COG1607	acyl-coa hydrolase
C7W88_RS13290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C7W88_RS13310	COG2951	lytic endotransglycosylase activity
C7W88_RS13320	COG1686	Belongs to the peptidase S11 family
C7W88_RS13325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C7W88_RS13335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C7W88_RS13340	COG0084	hydrolase, TatD family'
C7W88_RS13350	COG3956	TIGRFAM MazG family protein
C7W88_RS13355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C7W88_RS13360	COG1923	regulation of RNA biosynthetic process
C7W88_RS13370	COG5000	phosphorelay sensor kinase activity
C7W88_RS13375	COG2204	response regulator
C7W88_RS13380	COG3852	Histidine kinase
C7W88_RS13390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C7W88_RS13390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C7W88_RS13400	COG1546	Belongs to the CinA family
C7W88_RS13400	COG1058	Belongs to the CinA family
C7W88_RS13410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C7W88_RS13425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C7W88_RS13445	COG0315	cyclic pyranopterin monophosphate synthase activity
C7W88_RS13465	COG2333	competence protein COMEC
C7W88_RS13465	COG0658	competence protein
C7W88_RS13475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C7W88_RS13490	COG2205	protein histidine kinase activity
C7W88_RS13515	COG0587	DNA-directed DNA polymerase activity
C7W88_RS13550	COG0531	amino acid
C7W88_RS13555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C7W88_RS13565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS13575	COG2204	response regulator
C7W88_RS13580	COG2205	protein histidine kinase activity
C7W88_RS13580	COG0784	Response regulator, receiver
C7W88_RS13585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C7W88_RS13600	COG0484	heat shock protein binding
C7W88_RS13605	COG0443	Heat shock 70 kDa protein
C7W88_RS13625	COG1335	isochorismatase
C7W88_RS13630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C7W88_RS13635	COG1420	regulation of RNA biosynthetic process
C7W88_RS13640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C7W88_RS13645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C7W88_RS13650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7W88_RS13680	COG0488	(ABC) transporter
C7W88_RS13690	COG0438	transferase activity, transferring glycosyl groups
C7W88_RS13695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C7W88_RS13705	COG1862	Preprotein translocase
C7W88_RS13725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C7W88_RS13735	COG0439	Biotin carboxylase
C7W88_RS13745	COG0586	Pfam SNARE associated Golgi protein
C7W88_RS13750	COG0189	ligase activity
C7W88_RS13760	COG0792	nuclease activity
C7W88_RS13765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C7W88_RS13775	COG0187	DNA topoisomerase II activity
C7W88_RS13790	COG0542	response to heat
C7W88_RS13820	COG1024	Enoyl-CoA hydratase
C7W88_RS13845	COG3876	Protein conserved in bacteria
C7W88_RS13860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C7W88_RS13870	COG2814	Major facilitator Superfamily
C7W88_RS13885	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS13890	COG0789	Transcriptional regulator
C7W88_RS13910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C7W88_RS13910	COG0574	Belongs to the PEP-utilizing enzyme family
C7W88_RS13920	COG0752	glycyl-tRNA synthetase alpha subunit
C7W88_RS13945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C7W88_RS13950	COG0193	aminoacyl-tRNA hydrolase activity
C7W88_RS13975	COG0012	GTP binding
C7W88_RS13995	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS13995	COG2030	dehydratase
C7W88_RS14015	COG1792	Involved in formation and maintenance of cell shape
C7W88_RS14030	COG0772	Belongs to the SEDS family
C7W88_RS14055	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C7W88_RS14090	COG0148	phosphopyruvate hydratase activity
C7W88_RS14120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C7W88_RS14135	COG0505	Belongs to the CarA family
C7W88_RS14145	COG0358	DNA primase activity
C7W88_RS14150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C7W88_RS14155	COG0275	rRNA processing
C7W88_RS14170	COG0698	ribose 5-phosphate isomerase
C7W88_RS14175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C7W88_RS14185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C7W88_RS14200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C7W88_RS14210	COG0343	queuine tRNA-ribosyltransferase activity
C7W88_RS14225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C7W88_RS14235	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C7W88_RS14245	COG1722	exodeoxyribonuclease VII activity
C7W88_RS14255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C7W88_RS14270	COG0560	Phosphoserine phosphatase
C7W88_RS14275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C7W88_RS14280	COG0028	Belongs to the TPP enzyme family
C7W88_RS14285	COG0440	acetolactate synthase activity
C7W88_RS14290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C7W88_RS14300	COG2353	YceI-like domain
C7W88_RS14305	COG0596	Alpha beta hydrolase
C7W88_RS14310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7W88_RS14315	COG3618	amidohydrolase
C7W88_RS14335	COG0655	NAD(P)H dehydrogenase (quinone) activity
C7W88_RS14345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C7W88_RS14360	COG5002	protein histidine kinase activity
C7W88_RS14365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C7W88_RS14370	COG0573	inorganic phosphate transmembrane transporter activity
C7W88_RS14375	COG0581	inorganic phosphate transmembrane transporter activity
C7W88_RS14380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C7W88_RS14385	COG0704	Plays a role in the regulation of phosphate uptake
C7W88_RS14390	COG0745	RESPONSE REGULATOR receiver
C7W88_RS14410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C7W88_RS14420	COG1007	ATP synthesis coupled electron transport
C7W88_RS14435	COG0713	ATP synthesis coupled electron transport
C7W88_RS14445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7W88_RS14450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C7W88_RS14455	COG1034	ATP synthesis coupled electron transport
C7W88_RS14460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C7W88_RS14465	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C7W88_RS14480	COG0649	NAD binding
C7W88_RS14485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7W88_RS14490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7W88_RS14495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C7W88_RS14500	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS14510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C7W88_RS14515	COG0183	Belongs to the thiolase family
C7W88_RS14530	COG0004	ammonium transporteR
C7W88_RS14555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C7W88_RS14565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C7W88_RS14570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C7W88_RS14575	COG0860	N-Acetylmuramoyl-L-alanine amidase
C7W88_RS14580	COG1530	ribonuclease E activity
C7W88_RS14590	COG2226	methyltransferase
C7W88_RS14600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C7W88_RS14615	COG2200	EAL domain
C7W88_RS14615	COG2203	Gaf domain
C7W88_RS14615	COG2199	diguanylate cyclase activity
C7W88_RS14620	COG0367	asparagine synthase
C7W88_RS14645	COG3409	Peptidoglycan-binding domain 1 protein
C7W88_RS14645	COG3267	Type II secretory pathway component ExeA
C7W88_RS14670	COG0019	diaminopimelate decarboxylase activity
C7W88_RS14675	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS14700	COG0492	ferredoxin-NADP+ reductase activity
C7W88_RS14705	COG2365	Tyrosine phosphatase family
C7W88_RS14710	COG0784	Response regulator, receiver
C7W88_RS14715	COG3920	Histidine kinase
C7W88_RS14720	COG2050	protein possibly involved in aromatic compounds catabolism
C7W88_RS14725	COG1473	amidohydrolase
C7W88_RS14730	COG0183	Belongs to the thiolase family
C7W88_RS14790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C7W88_RS14795	COG1199	ATP-dependent helicase activity
C7W88_RS14815	COG0776	regulation of translation
C7W88_RS14820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7W88_RS14825	COG0416	fatty acid biosynthetic process
C7W88_RS14830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C7W88_RS14840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C7W88_RS14900	COG0215	cysteine-tRNA ligase activity
C7W88_RS14980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C7W88_RS15010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C7W88_RS15010	COG2169	Transcriptional regulator
C7W88_RS15020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C7W88_RS15025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C7W88_RS15030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C7W88_RS15035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C7W88_RS15040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C7W88_RS15045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7W88_RS15105	COG0745	RESPONSE REGULATOR receiver
C7W88_RS15135	COG0667	Aldo Keto reductase
C7W88_RS15145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C7W88_RS15160	COG2897	thiosulfate sulfurtransferase activity
C7W88_RS15165	COG0626	cystathionine gamma-synthase activity
C7W88_RS15170	COG3264	Mechanosensitive ion channel
C7W88_RS15170	COG1196	nuclear chromosome segregation
C7W88_RS15175	COG1648	precorrin-2 dehydrogenase activity
C7W88_RS15175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7W88_RS15195	COG0175	sulfate reduction
C7W88_RS15200	COG0471	metal ion transport
C7W88_RS15235	COG0800	Aldolase
C7W88_RS15240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C7W88_RS15265	COG0348	domain, Protein
C7W88_RS15270	COG2010	Cytochrome c
C7W88_RS15290	COG3047	cAMP biosynthetic process
C7W88_RS15295	COG4771	TonB-dependent receptor
C7W88_RS15325	COG0481	GTPase activity
C7W88_RS15345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C7W88_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS15360	COG0137	argininosuccinate synthase activity
C7W88_RS15385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS15395	COG0583	DNA-binding transcription factor activity
C7W88_RS15420	COG1063	alcohol dehydrogenase
C7W88_RS15425	COG0436	Aminotransferase
C7W88_RS15450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C7W88_RS15475	COG1505	serine-type exopeptidase activity
C7W88_RS15480	COG1505	serine-type exopeptidase activity
C7W88_RS15485	COG0203	ribosomal protein L17
C7W88_RS15490	COG0202	RNA polymerase activity
C7W88_RS15495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C7W88_RS15500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C7W88_RS15520	COG1305	Transglutaminase-like
C7W88_RS15525	COG2133	pyrroloquinoline quinone binding
C7W88_RS15540	COG0408	coproporphyrinogen oxidase activity
C7W88_RS15550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C7W88_RS15575	COG0745	RESPONSE REGULATOR receiver
C7W88_RS15580	COG3158	transport of potassium into the cell
C7W88_RS15590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C7W88_RS15590	COG0438	transferase activity, transferring glycosyl groups
C7W88_RS15600	COG1695	Transcriptional regulator
C7W88_RS15605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C7W88_RS15640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7W88_RS15640	COG2010	Cytochrome c
C7W88_RS15685	COG0045	succinate-CoA ligase (ADP-forming) activity
C7W88_RS15710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C7W88_RS15715	COG0248	Ppx GppA phosphatase
C7W88_RS15730	COG0477	Major facilitator Superfamily
C7W88_RS15795	COG1522	sequence-specific DNA binding
C7W88_RS15825	COG2151	metal-sulfur cluster biosynthetic enzyme
C7W88_RS15835	COG3460	Phenylacetate-CoA oxygenase
C7W88_RS15840	COG3396	Phenylacetate-CoA oxygenase
C7W88_RS15845	COG1024	Enoyl-CoA hydratase
C7W88_RS15850	COG2030	dehydratase
C7W88_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS15865	COG1309	transcriptional regulator
C7W88_RS15870	COG4771	TonB-dependent receptor
C7W88_RS15875	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS15880	COG2814	Major facilitator Superfamily
C7W88_RS15905	COG3104	oligopeptide transport
C7W88_RS15930	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS15935	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS15940	COG1024	Enoyl-CoA hydratase
C7W88_RS15945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C7W88_RS15975	COG0251	oxidation-reduction process
C7W88_RS16000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS16005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7W88_RS16045	COG0183	Belongs to the thiolase family
C7W88_RS16060	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS16065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS16070	COG1024	Enoyl-CoA hydratase
C7W88_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS16085	COG0006	proline dipeptidase activity
C7W88_RS16090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C7W88_RS16110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C7W88_RS16145	COG0457	Tetratricopeptide repeat
C7W88_RS16150	COG0457	Tetratricopeptide repeat
C7W88_RS16190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C7W88_RS16190	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7W88_RS16200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7W88_RS16250	COG3138	arginine N-succinyltransferase
C7W88_RS16265	COG4372	Transposase
C7W88_RS16270	COG3436	PFAM IS66 Orf2 family protein
C7W88_RS16310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7W88_RS16330	COG0022	dehydrogenase e1 component
C7W88_RS16335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7W88_RS16350	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS16360	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS16470	COG1522	sequence-specific DNA binding
C7W88_RS16490	COG0625	glutathione transferase activity
C7W88_RS16515	COG2936	dipeptidyl-peptidase activity
C7W88_RS16525	COG2814	Major facilitator Superfamily
C7W88_RS16535	COG0277	FAD linked oxidase domain protein
C7W88_RS16545	COG0534	Mate efflux family protein
C7W88_RS16550	COG1802	Transcriptional regulator
C7W88_RS16555	COG4771	TonB-dependent receptor
C7W88_RS16560	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS16565	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7W88_RS16590	COG4948	Mandelate Racemase Muconate Lactonizing
C7W88_RS16605	COG2843	Capsule synthesis protein
C7W88_RS16625	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS16665	COG1053	succinate dehydrogenase
C7W88_RS16670	COG1053	succinate dehydrogenase
C7W88_RS16780	COG4227	nucleotidyltransferase activity
C7W88_RS16830	COG5642	Protein of unknown function (DUF2384)
C7W88_RS16845	COG1196	nuclear chromosome segregation
C7W88_RS16845	COG0741	lytic transglycosylase activity
C7W88_RS16845	COG0739	heme binding
C7W88_RS16890	COG0367	asparagine synthase
C7W88_RS16925	COG0582	viral genome integration into host DNA
C7W88_RS17130	COG0840	transmembrane signaling receptor activity
C7W88_RS17130	COG2972	Histidine kinase
C7W88_RS17135	COG0840	transmembrane signaling receptor activity
C7W88_RS17160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C7W88_RS17210	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C7W88_RS17295	COG1690	Belongs to the RtcB family
C7W88_RS17310	COG0629	single-stranded DNA binding
C7W88_RS17315	COG0840	transmembrane signaling receptor activity
C7W88_RS17350	COG5001	Diguanylate cyclase
C7W88_RS17355	COG4251	negative regulation of phosphorylation
C7W88_RS17355	COG5001	Diguanylate cyclase
C7W88_RS17355	COG3706	GGDEF domain
C7W88_RS17355	COG2203	Gaf domain
C7W88_RS17420	COG2826	transposase and inactivated derivatives, IS30 family
C7W88_RS17515	COG0673	inositol 2-dehydrogenase activity
C7W88_RS17535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C7W88_RS17620	COG3206	protein involved in exopolysaccharide biosynthesis
C7W88_RS17620	COG0489	protein tyrosine kinase activity
C7W88_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS17770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C7W88_RS17810	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS17815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C7W88_RS17820	COG0243	molybdopterin cofactor binding
C7W88_RS17825	COG2146	nitrite reductase [NAD(P)H] activity
C7W88_RS17830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C7W88_RS17840	COG1116	anion transmembrane transporter activity
C7W88_RS17845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C7W88_RS17850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C7W88_RS17850	COG1116	anion transmembrane transporter activity
C7W88_RS17870	COG0471	metal ion transport
C7W88_RS17870	COG3273	potassium ion transport
C7W88_RS17920	COG3795	YCII-related domain
C7W88_RS17945	COG0419	ATPase involved in DNA repair
C7W88_RS17960	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C7W88_RS18045	COG0446	pyridine nucleotide-disulphide oxidoreductase
C7W88_RS18045	COG1902	pentaerythritol trinitrate reductase activity
C7W88_RS18065	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS18125	COG1522	sequence-specific DNA binding
C7W88_RS18130	COG4206	TonB-dependent receptor
C7W88_RS18190	COG2963	transposase activity
C7W88_RS18195	COG3436	PFAM IS66 Orf2 family protein
C7W88_RS18200	COG4372	Transposase
C7W88_RS18230	COG2271	Major facilitator Superfamily
C7W88_RS18300	COG0596	Alpha beta hydrolase
C7W88_RS18305	COG0028	Belongs to the TPP enzyme family
C7W88_RS18325	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS18330	COG1309	transcriptional regulator
C7W88_RS18360	COG3119	arylsulfatase activity
C7W88_RS18375	COG2721	sulfolactate sulfo-lyase activity
C7W88_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS18400	COG2272	Belongs to the type-B carboxylesterase lipase family
C7W88_RS18430	COG1904	glucuronate isomerase
C7W88_RS18435	COG0246	Mannitol dehydrogenase
C7W88_RS18465	COG4585	Histidine kinase
C7W88_RS18470	COG2197	response regulator
C7W88_RS18480	COG0783	Belongs to the Dps family
C7W88_RS18485	COG1335	isochorismatase
C7W88_RS18495	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C7W88_RS18525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7W88_RS18540	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C7W88_RS18545	COG3387	PFAM Glycoside hydrolase 15-related
C7W88_RS18550	COG1877	trehalose-phosphatase activity
C7W88_RS18560	COG0583	DNA-binding transcription factor activity
C7W88_RS18565	COG0471	metal ion transport
C7W88_RS18565	COG3273	potassium ion transport
C7W88_RS18580	COG3119	arylsulfatase activity
C7W88_RS18585	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7W88_RS18595	COG4771	TonB-dependent receptor
C7W88_RS18605	COG0840	transmembrane signaling receptor activity
C7W88_RS18615	COG2130	NADP-dependent
C7W88_RS18640	COG0798	PFAM Bile acid sodium symporter
C7W88_RS18665	COG2130	NADP-dependent
C7W88_RS18675	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS18685	COG2130	NADP-dependent
C7W88_RS18705	COG4638	Rieske (2fe-2S)
C7W88_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS18770	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7W88_RS18785	COG3622	Belongs to the hyi family
C7W88_RS18790	COG2852	Protein conserved in bacteria
C7W88_RS18795	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C7W88_RS18840	COG3622	Belongs to the hyi family
C7W88_RS18845	COG4774	siderophore transport
C7W88_RS18850	COG1024	Enoyl-CoA hydratase
C7W88_RS18860	COG0753	catalase activity
C7W88_RS18880	COG0657	acetylesterase activity
C7W88_RS18880	COG2755	lipolytic protein G-D-S-L family
C7W88_RS18895	COG3474	cytochrome
C7W88_RS18925	COG2223	nitrite transmembrane transporter activity
C7W88_RS18985	COG2814	Major facilitator Superfamily
C7W88_RS19005	COG4771	TonB-dependent receptor
C7W88_RS19020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C7W88_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS19040	COG1335	isochorismatase
C7W88_RS19050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7W88_RS19075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7W88_RS19080	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS19090	COG2336	PFAM SpoVT AbrB
C7W88_RS19095	COG2337	Toxic component of a toxin-antitoxin (TA) module
C7W88_RS19100	COG1414	Transcriptional regulator
C7W88_RS19105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7W88_RS19115	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
C7W88_RS19140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS19145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7W88_RS19155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C7W88_RS19160	COG2130	NADP-dependent
C7W88_RS19190	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS19235	COG1335	isochorismatase
C7W88_RS19270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C7W88_RS19280	COG2211	Major facilitator Superfamily
C7W88_RS19295	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS19300	COG2211	Major facilitator Superfamily
C7W88_RS19310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C7W88_RS19345	COG0508	dehydrogenase complex catalyzes the overall conversion of
C7W88_RS19350	COG0022	dehydrogenase e1 component
C7W88_RS19355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C7W88_RS19360	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS19365	COG0183	Belongs to the thiolase family
C7W88_RS19375	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7W88_RS19415	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS19420	COG0840	transmembrane signaling receptor activity
C7W88_RS19430	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS19545	COG4771	TonB-dependent receptor
C7W88_RS19550	COG2272	Belongs to the type-B carboxylesterase lipase family
C7W88_RS19555	COG3250	beta-galactosidase activity
C7W88_RS19560	COG2271	Major facilitator Superfamily
C7W88_RS19580	COG4948	Mandelate Racemase Muconate Lactonizing
C7W88_RS19590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C7W88_RS19595	COG4771	TonB-dependent receptor
C7W88_RS19600	COG3250	beta-galactosidase activity
C7W88_RS19615	COG2271	Major facilitator Superfamily
C7W88_RS19630	COG1904	glucuronate isomerase
C7W88_RS19635	COG0246	Mannitol dehydrogenase
C7W88_RS19740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C7W88_RS19745	COG2814	Major facilitator Superfamily
C7W88_RS19755	COG1609	Transcriptional regulator
C7W88_RS19770	COG1053	succinate dehydrogenase
C7W88_RS19790	COG4638	Rieske (2fe-2S)
C7W88_RS19810	COG3661	Belongs to the glycosyl hydrolase 67 family
C7W88_RS19835	COG1609	Transcriptional regulator
C7W88_RS19840	COG0477	Major facilitator Superfamily
C7W88_RS19900	COG2186	Transcriptional regulator
C7W88_RS19920	COG2115	Belongs to the xylose isomerase family
C7W88_RS19925	COG1070	Carbohydrate kinase
C7W88_RS19935	COG0800	Aldolase
C7W88_RS19940	COG3734	2-keto-3-deoxy-galactonokinase
C7W88_RS20005	COG0492	ferredoxin-NADP+ reductase activity
C7W88_RS20020	COG4638	Rieske (2fe-2S)
C7W88_RS20025	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS20035	COG1522	sequence-specific DNA binding
C7W88_RS20070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C7W88_RS20090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C7W88_RS20100	COG2423	ornithine cyclodeaminase activity
C7W88_RS20130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7W88_RS20140	COG1012	belongs to the aldehyde dehydrogenase family
C7W88_RS20145	COG0473	3-isopropylmalate dehydrogenase activity
C7W88_RS20180	COG1522	sequence-specific DNA binding
C7W88_RS20185	COG1473	amidohydrolase
C7W88_RS20240	COG1522	sequence-specific DNA binding
C7W88_RS20245	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20265	COG1902	pentaerythritol trinitrate reductase activity
C7W88_RS20275	COG1522	sequence-specific DNA binding
C7W88_RS20285	COG1053	succinate dehydrogenase
C7W88_RS20300	COG4771	TonB-dependent receptor
C7W88_RS20310	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C7W88_RS20345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C7W88_RS20365	COG1056	cytidyltransferase-related domain
C7W88_RS20365	COG1051	belongs to the nudix hydrolase family
C7W88_RS20390	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20405	COG0302	gtp cyclohydrolase
C7W88_RS20445	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7W88_RS20495	COG2124	cytochrome p450
C7W88_RS20500	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20535	COG1082	Xylose isomerase domain protein TIM barrel
C7W88_RS20550	COG1309	transcriptional regulator
C7W88_RS20565	COG2072	flavoprotein involved in K transport
C7W88_RS20575	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20585	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS20605	COG2084	Dehydrogenase
C7W88_RS20615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C7W88_RS20620	COG1024	Enoyl-CoA hydratase
C7W88_RS20630	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20640	COG3250	beta-galactosidase activity
C7W88_RS20655	COG1309	transcriptional regulator
C7W88_RS20670	COG1309	transcriptional regulator
C7W88_RS20675	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20680	COG0673	inositol 2-dehydrogenase activity
C7W88_RS20710	COG0346	lactoylglutathione lyase activity
C7W88_RS20715	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20720	COG4638	Rieske (2fe-2S)
C7W88_RS20725	COG4977	sequence-specific DNA binding
C7W88_RS20735	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C7W88_RS20795	COG1024	Enoyl-CoA hydratase
C7W88_RS20805	COG1024	Enoyl-CoA hydratase
C7W88_RS20810	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20815	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20820	COG0183	Belongs to the thiolase family
C7W88_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20835	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20840	COG1960	acyl-CoA dehydrogenase activity
C7W88_RS20845	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20860	COG0183	Belongs to the thiolase family
C7W88_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS20890	COG1309	transcriptional regulator
C7W88_RS20945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C7W88_RS20950	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C7W88_RS21005	COG1218	3'(2'),5'-bisphosphate nucleotidase
C7W88_RS21015	COG4771	TonB-dependent receptor
C7W88_RS21030	COG3384	dioxygenase
C7W88_RS21040	COG0318	PFAM AMP-dependent synthetase and ligase
C7W88_RS21045	COG2186	Transcriptional regulator
C7W88_RS21050	COG4774	siderophore transport
C7W88_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS21060	COG3300	MHYT domain
C7W88_RS21060	COG5001	Diguanylate cyclase
C7W88_RS21065	COG0642	Histidine kinase
C7W88_RS21070	COG5002	protein histidine kinase activity
C7W88_RS21075	COG4206	TonB-dependent receptor
C7W88_RS21100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C7W88_RS21110	COG1566	PFAM secretion protein HlyD family protein
C7W88_RS21165	COG0746	molybdenum cofactor guanylyltransferase activity
C7W88_RS21170	COG3383	formate dehydrogenase (NAD+) activity
C7W88_RS21180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C7W88_RS21215	COG1054	Belongs to the UPF0176 family
C7W88_RS21220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C7W88_RS21230	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C7W88_RS21285	COG0673	inositol 2-dehydrogenase activity
C7W88_RS21360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C7W88_RS21380	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C7W88_RS21395	COG1088	dTDP-glucose 4,6-dehydratase activity
C7W88_RS21400	COG4957	zinc ion binding
C7W88_RS21435	COG3311	Transcriptional regulator
C7W88_RS21440	COG4644	lycopene metabolic process
C7W88_RS21450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C7W88_RS21460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C7W88_RS21460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C7W88_RS21490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C7W88_RS21525	COG3153	acetyltransferase
C7W88_RS21560	COG4227	nucleotidyltransferase activity
C7W88_RS21575	COG1525	nuclease
C7W88_RS21580	COG0784	Response regulator, receiver
C7W88_RS21580	COG4191	Histidine kinase
C7W88_RS21585	COG0784	Response regulator, receiver
C7W88_RS21585	COG4191	Histidine kinase
C7W88_RS21605	COG5001	Diguanylate cyclase
C7W88_RS21670	COG1609	Transcriptional regulator
C7W88_RS21675	COG1621	beta-fructofuranosidase activity
C7W88_RS21680	COG4771	TonB-dependent receptor
C7W88_RS21705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C7W88_RS21715	COG3609	addiction module antidote protein, CC2985 family
C7W88_RS21730	COG3706	GGDEF domain
C7W88_RS21755	COG3540	Alkaline phosphatase
C7W88_RS21770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C7W88_RS21780	COG4771	TonB-dependent receptor
C7W88_RS21785	COG1737	Transcriptional regulator
C7W88_RS21865	COG0629	single-stranded DNA binding
C7W88_RS21895	COG2826	transposase and inactivated derivatives, IS30 family
C7W88_RS21905	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
C7W88_RS21910	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C7W88_RS22085	COG2851	Citrate transporter
C7W88_RS22090	COG0583	DNA-binding transcription factor activity
C7W88_RS22105	COG0667	Aldo Keto reductase
C7W88_RS22110	COG2080	2 iron, 2 sulfur cluster binding
C7W88_RS22115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C7W88_RS22115	COG2010	Cytochrome c
C7W88_RS22140	COG1090	epimerase
C7W88_RS22180	COG1506	peptidase
C7W88_RS22180	COG0823	Involved in the tonB-independent uptake of proteins
C7W88_RS22210	COG1802	Transcriptional regulator
C7W88_RS22275	COG0861	Integral membrane protein TerC family
C7W88_RS22280	COG0514	ATP-dependent DNA helicase (RecQ)
C7W88_RS22320	COG0495	leucyl-tRNA aminoacylation
C7W88_RS22335	COG1028	Short-chain dehydrogenase reductase Sdr
C7W88_RS22380	COG0640	Transcriptional regulator