locus-tag	class	description
DR92_RS00110	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR92_RS00215	COG1132	(ABC) transporter
DR92_RS00230	COG1368	sulfuric ester hydrolase activity
DR92_RS00355	COG0646	methionine synthase
DR92_RS00355	COG1410	methionine synthase
DR92_RS00515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DR92_RS00515	COG0116	Belongs to the methyltransferase superfamily
DR92_RS00560	COG0281	malic enzyme
DR92_RS00560	COG0280	phosphate acetyltransferase
DR92_RS00570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DR92_RS00575	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DR92_RS00585	COG0728	peptidoglycan biosynthetic process
DR92_RS00625	COG1643	Atp-dependent helicase
DR92_RS00690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS00690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS00695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS00695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS00790	COG3459	Glycosyltransferase 36 associated
DR92_RS00815	COG4208	sulfate ABC transporter
DR92_RS00870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DR92_RS01135	COG0646	methionine synthase
DR92_RS01135	COG1410	methionine synthase
DR92_RS01310	COG0280	phosphate acetyltransferase
DR92_RS01310	COG0281	malic enzyme
DR92_RS01320	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DR92_RS01340	COG0728	peptidoglycan biosynthetic process
DR92_RS01400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR92_RS01495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR92_RS01820	COG1643	Atp-dependent helicase
DR92_RS01910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DR92_RS01965	COG3459	Glycosyltransferase 36 associated
DR92_RS01980	COG3459	Glycosyltransferase 36 associated
DR92_RS01985	COG3459	Glycosyltransferase 36 associated
DR92_RS02085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DR92_RS02400	COG1960	acyl-CoA dehydrogenase activity
DR92_RS02625	COG4964	Belongs to the GSP D family
DR92_RS02955	COG2814	Major facilitator Superfamily
DR92_RS03005	COG3135	benzoate transporter
DR92_RS03180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DR92_RS04360	COG0495	leucyl-tRNA aminoacylation
DR92_RS04510	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DR92_RS05110	COG0037	tRNA processing
DR92_RS05125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR92_RS05775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DR92_RS06055	COG1879	ABC-type sugar transport system periplasmic component
DR92_RS06250	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS06270	COG1177	transmembrane transport
DR92_RS06490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR92_RS06490	COG0512	Glutamine amidotransferase of anthranilate synthase
DR92_RS07050	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DR92_RS07120	COG0210	DNA helicase
DR92_RS07330	COG3158	transport of potassium into the cell
DR92_RS07350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR92_RS07645	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DR92_RS07870	COG0747	negative chemotaxis
DR92_RS08040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DR92_RS08050	COG0085	RNA polymerase activity
DR92_RS08425	COG0052	Belongs to the universal ribosomal protein uS2 family
DR92_RS08585	COG0504	CTP synthase activity
DR92_RS09100	COG0427	acetyl-CoA hydrolase
DR92_RS09385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DR92_RS09630	COG0513	Belongs to the DEAD box helicase family
DR92_RS10070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DR92_RS10085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR92_RS10095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR92_RS10120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DR92_RS10130	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR92_RS10130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DR92_RS10145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DR92_RS10150	COG1732	Glycine betaine
DR92_RS10155	COG1174	glycine betaine transport
DR92_RS10160	COG1125	glycine betaine transport
DR92_RS10165	COG1174	glycine betaine transport
DR92_RS10170	COG0789	Transcriptional regulator
DR92_RS10175	COG4993	Dehydrogenase
DR92_RS10185	COG1879	ABC-type sugar transport system periplasmic component
DR92_RS10190	COG1129	ABC transporter
DR92_RS10195	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR92_RS10200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR92_RS10205	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
DR92_RS10215	COG5001	Diguanylate cyclase
DR92_RS10220	COG0351	phosphomethylpyrimidine kinase
DR92_RS10235	COG2022	thiamine diphosphate biosynthetic process
DR92_RS10245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR92_RS10250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DR92_RS10255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR92_RS10260	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS10265	COG5265	(ABC) transporter
DR92_RS10270	COG1368	sulfuric ester hydrolase activity
DR92_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS10310	COG2197	response regulator
DR92_RS10330	COG1218	3'(2'),5'-bisphosphate nucleotidase
DR92_RS10340	COG0175	sulfate reduction
DR92_RS10345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DR92_RS10350	COG2197	response regulator
DR92_RS10385	COG0175	sulfate reduction
DR92_RS10390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR92_RS10400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR92_RS10400	COG1648	precorrin-2 dehydrogenase activity
DR92_RS10405	COG0792	nuclease activity
DR92_RS10410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DR92_RS10415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DR92_RS10420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR92_RS10430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DR92_RS10440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DR92_RS10450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR92_RS10470	COG0071	Belongs to the small heat shock protein (HSP20) family
DR92_RS10480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR92_RS10485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR92_RS10495	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DR92_RS10500	COG1137	ATPase activity
DR92_RS10505	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DR92_RS10515	COG0616	signal peptide processing
DR92_RS10530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DR92_RS10530	COG0116	Belongs to the methyltransferase superfamily
DR92_RS10535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR92_RS10550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DR92_RS10555	COG0280	phosphate acetyltransferase
DR92_RS10555	COG0281	malic enzyme
DR92_RS10560	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DR92_RS10565	COG0728	peptidoglycan biosynthetic process
DR92_RS10570	COG0180	Tryptophanyl-tRNA synthetase
DR92_RS10580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DR92_RS10585	COG1376	ErfK ybiS ycfS ynhG family protein
DR92_RS10585	COG1388	LysM domain
DR92_RS10595	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DR92_RS10610	COG1643	Atp-dependent helicase
DR92_RS10615	COG0519	Catalyzes the synthesis of GMP from XMP
DR92_RS10630	COG2153	protein acetylation
DR92_RS10640	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DR92_RS10645	COG2124	cytochrome p450
DR92_RS10660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS10660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR92_RS10665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DR92_RS10690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DR92_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS10705	COG1280	lysine exporter protein (LysE YggA)
DR92_RS10710	COG2226	methyltransferase
DR92_RS10715	COG0384	phenazine biosynthesis protein PhzF
DR92_RS10720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DR92_RS10725	COG3459	Glycosyltransferase 36 associated
DR92_RS10730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DR92_RS10735	COG4208	sulfate ABC transporter
DR92_RS10740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DR92_RS10765	COG2199	diguanylate cyclase activity
DR92_RS10785	COG0129	dihydroxy-acid dehydratase activity
DR92_RS10795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR92_RS10805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR92_RS10810	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR92_RS10820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DR92_RS10845	COG0670	Belongs to the BI1 family
DR92_RS10855	COG4181	ATPase activity
DR92_RS10865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DR92_RS10875	COG2154	pterin-4-alpha-carbinolamine dehydratase
DR92_RS10885	COG3339	Conserved Protein
DR92_RS10895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DR92_RS10915	COG0137	argininosuccinate synthase activity
DR92_RS10920	COG0024	Methionine aminopeptidase
DR92_RS10930	COG1846	Transcriptional regulator
DR92_RS10955	COG1272	protein, Hemolysin III
DR92_RS10985	COG1072	(Pantothenic acid kinase))
DR92_RS11020	COG0033	Phosphoglucomutase
DR92_RS11025	COG0489	protein tyrosine kinase activity
DR92_RS11035	COG0346	lactoylglutathione lyase activity
DR92_RS11070	COG1376	ErfK ybiS ycfS ynhG family protein
DR92_RS11090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DR92_RS11095	COG1845	cytochrome c oxidase, subunit III
DR92_RS11100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DR92_RS11105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DR92_RS11135	COG1024	Enoyl-CoA hydratase
DR92_RS11150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR92_RS11155	COG1960	acyl-CoA dehydrogenase activity
DR92_RS11160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR92_RS11165	COG0697	spore germination
DR92_RS11175	COG0625	glutathione transferase activity
DR92_RS11190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DR92_RS11200	COG0539	negative regulation of cytoplasmic translation
DR92_RS11210	COG2855	membrane
DR92_RS11215	COG0583	DNA-binding transcription factor activity
DR92_RS11230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DR92_RS11235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DR92_RS11240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DR92_RS11250	COG2816	NAD+ diphosphatase activity
DR92_RS11255	COG0077	Prephenate dehydratase
DR92_RS11255	COG1605	Chorismate mutase
DR92_RS11260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DR92_RS11265	COG3474	cytochrome
DR92_RS11270	COG4166	transmembrane transport
DR92_RS11280	COG4174	ABC transporter (Permease)
DR92_RS11285	COG4239	(ABC) transporter, permease
DR92_RS11290	COG4172	Belongs to the ABC transporter superfamily
DR92_RS11310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DR92_RS11335	COG0268	Binds directly to 16S ribosomal RNA
DR92_RS11345	COG1024	Enoyl-CoA hydratase
DR92_RS11385	COG4964	Belongs to the GSP D family
DR92_RS11420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DR92_RS11430	COG0791	NLP P60 protein
DR92_RS11450	COG0456	acetyltransferase
DR92_RS11465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DR92_RS11475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR92_RS11485	COG1185	polyribonucleotide nucleotidyltransferase activity
DR92_RS11490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR92_RS11495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DR92_RS11500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DR92_RS11505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DR92_RS11505	COG3064	Membrane
DR92_RS11525	COG0779	Required for maturation of 30S ribosomal subunits
DR92_RS11530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DR92_RS11535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DR92_RS11540	COG1396	sequence-specific DNA binding
DR92_RS11555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DR92_RS11565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DR92_RS11580	COG1214	PFAM Peptidase M22, glycoprotease
DR92_RS11585	COG0783	Belongs to the Dps family
DR92_RS11590	COG2309	aminopeptidase activity
DR92_RS11600	COG3773	Cell wall hydrolase
DR92_RS11615	COG0745	RESPONSE REGULATOR receiver
DR92_RS11620	COG0704	Plays a role in the regulation of phosphate uptake
DR92_RS11625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR92_RS11635	COG0573	inorganic phosphate transmembrane transporter activity
DR92_RS11645	COG0436	Aminotransferase
DR92_RS11650	COG2832	Protein of unknown function (DUF454)
DR92_RS11660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DR92_RS11665	COG0189	ligase activity
DR92_RS11670	COG1214	PFAM Peptidase M22, glycoprotease
DR92_RS11670	COG0456	acetyltransferase
DR92_RS11700	COG0606	chelatase, subunit chli
DR92_RS11730	COG3963	phosphatidate phosphatase activity
DR92_RS11735	COG0484	heat shock protein binding
DR92_RS11760	COG0667	Aldo Keto reductase
DR92_RS11765	COG2814	Major facilitator Superfamily
DR92_RS11770	COG1309	transcriptional regulator
DR92_RS11780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DR92_RS11790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DR92_RS11795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DR92_RS11805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DR92_RS11810	COG0596	Alpha beta hydrolase
DR92_RS11810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DR92_RS11815	COG3135	benzoate transporter
DR92_RS11840	COG0133	tryptophan synthase activity
DR92_RS11850	COG0159	tryptophan synthase activity
DR92_RS11855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DR92_RS11860	COG0285	dihydrofolate synthase activity
DR92_RS11870	COG1074	ATP-dependent DNA helicase activity
DR92_RS11875	COG2887	Belongs to the helicase family. UvrD subfamily
DR92_RS11880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DR92_RS11885	COG3178	'Phosphotransferase
DR92_RS11890	COG2205	protein histidine kinase activity
DR92_RS11895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DR92_RS11900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DR92_RS11905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR92_RS11910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR92_RS11910	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR92_RS11915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DR92_RS11920	COG2205	protein histidine kinase activity
DR92_RS11925	COG0745	RESPONSE REGULATOR receiver
DR92_RS11930	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DR92_RS11940	COG0596	Alpha beta hydrolase
DR92_RS11945	COG1072	(Pantothenic acid kinase))
DR92_RS11950	COG0140	phosphoribosyl-ATP diphosphatase activity
DR92_RS11955	COG0107	imidazoleglycerol-phosphate synthase activity
DR92_RS11960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DR92_RS11975	COG0131	Imidazoleglycerol-phosphate dehydratase
DR92_RS11980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DR92_RS11990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DR92_RS12025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DR92_RS12030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DR92_RS12035	COG0237	dephospho-CoA kinase activity
DR92_RS12050	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DR92_RS12055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DR92_RS12060	COG1981	membrane
DR92_RS12065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DR92_RS12070	COG1331	Highly conserved protein containing a thioredoxin domain
DR92_RS12075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DR92_RS12080	COG0445	tRNA wobble uridine modification
DR92_RS12085	COG0357	Ribosomal RNA small subunit methyltransferase G
DR92_RS12110	COG1122	ATPase activity
DR92_RS12115	COG4120	Belongs to the binding-protein-dependent transport system permease family
DR92_RS12125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DR92_RS12135	COG1609	Transcriptional regulator
DR92_RS12150	COG1024	Enoyl-CoA hydratase
DR92_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS12180	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS12190	COG1132	(ABC) transporter
DR92_RS12195	COG0582	viral genome integration into host DNA
DR92_RS12260	COG1396	sequence-specific DNA binding
DR92_RS12280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DR92_RS12280	COG0758	DNA mediated transformation
DR92_RS12295	COG1473	amidohydrolase
DR92_RS12300	COG1686	Belongs to the peptidase S11 family
DR92_RS12305	COG0523	cobalamin synthesis protein
DR92_RS12320	COG0825	malonyl-CoA metabolic process
DR92_RS12340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DR92_RS12345	COG4536	flavin adenine dinucleotide binding
DR92_RS12370	COG4221	oxidoreductase activity
DR92_RS12375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DR92_RS12380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DR92_RS12390	COG0789	Transcriptional regulator
DR92_RS12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DR92_RS12410	COG2917	probably involved in intracellular septation
DR92_RS12415	COG0552	protein localization to endoplasmic reticulum
DR92_RS12420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DR92_RS12425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DR92_RS12435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DR92_RS12440	COG0039	L-malate dehydrogenase activity
DR92_RS12445	COG0045	succinate-CoA ligase (ADP-forming) activity
DR92_RS12450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DR92_RS12455	COG0567	Dehydrogenase, E1 component
DR92_RS12460	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR92_RS12470	COG1280	lysine exporter protein (LysE YggA)
DR92_RS12500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DR92_RS12515	COG0335	large ribosomal subunit rRNA binding
DR92_RS12520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DR92_RS12525	COG3706	GGDEF domain
DR92_RS12565	COG1764	response to oxidative stress
DR92_RS12570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR92_RS12575	COG1946	Acyl-CoA thioesterase
DR92_RS12580	COG0004	ammonium transporteR
DR92_RS12590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DR92_RS12600	COG0488	(ABC) transporter
DR92_RS12610	COG0745	RESPONSE REGULATOR receiver
DR92_RS12620	COG2233	PERMEase
DR92_RS12625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR92_RS12630	COG0697	spore germination
DR92_RS12655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DR92_RS12660	COG0181	hydroxymethylbilane synthase activity
DR92_RS12705	COG2884	Cell division ATP-binding protein ftsE
DR92_RS12725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DR92_RS12745	COG0287	Prephenate dehydrogenase
DR92_RS12755	COG2226	methyltransferase
DR92_RS12780	COG0165	Argininosuccinate lyase
DR92_RS12785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR92_RS12790	COG1280	lysine exporter protein (LysE YggA)
DR92_RS12795	COG1671	Belongs to the UPF0178 family
DR92_RS12800	COG0697	spore germination
DR92_RS12810	COG0300	oxidoreductase activity
DR92_RS12825	COG0602	queuosine metabolic process
DR92_RS12830	COG0720	synthase
DR92_RS12835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DR92_RS12840	COG2086	electron transfer activity
DR92_RS12845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DR92_RS12850	COG1250	3-hydroxyacyl-CoA dehydrogenase
DR92_RS12890	COG0653	protein targeting
DR92_RS12895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR92_RS12910	COG0494	nUDIX hydrolase
DR92_RS12925	COG1040	competence protein
DR92_RS12950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR92_RS12955	COG0527	aspartate kinase activity
DR92_RS12965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DR92_RS12970	COG2890	protein-(glutamine-N5) methyltransferase activity
DR92_RS12985	COG1376	ErfK ybiS ycfS ynhG family protein
DR92_RS12990	COG0739	heme binding
DR92_RS13025	COG0456	acetyltransferase
DR92_RS13030	COG0534	Mate efflux family protein
DR92_RS13040	COG0500	methyltransferase
DR92_RS13050	COG2957	Belongs to the agmatine deiminase family
DR92_RS13065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DR92_RS13070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DR92_RS13085	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DR92_RS13090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DR92_RS13095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DR92_RS13105	COG0799	negative regulation of ribosome biogenesis
DR92_RS13110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DR92_RS13125	COG0793	Belongs to the peptidase S41A family
DR92_RS13135	COG0494	nUDIX hydrolase
DR92_RS13165	COG2130	NADP-dependent
DR92_RS13175	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DR92_RS13185	COG0288	reversible hydration of carbon dioxide
DR92_RS13195	COG1620	l-lactate permease
DR92_RS13200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR92_RS13205	COG0287	Prephenate dehydrogenase
DR92_RS13205	COG1605	Chorismate mutase
DR92_RS13210	COG0228	four-way junction DNA binding
DR92_RS13215	COG0456	acetyltransferase
DR92_RS13215	COG0454	-acetyltransferase
DR92_RS13220	COG1704	LemA family
DR92_RS13225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DR92_RS13240	COG2270	Major facilitator Superfamily
DR92_RS13245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DR92_RS13250	COG0138	bifunctional purine biosynthesis protein purh
DR92_RS13260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DR92_RS13260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR92_RS13265	COG0501	Belongs to the peptidase M48B family
DR92_RS13275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR92_RS13280	COG5425	PFAM Usg family protein
DR92_RS13285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR92_RS13290	COG0495	leucyl-tRNA aminoacylation
DR92_RS13310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DR92_RS13325	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DR92_RS13330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DR92_RS13335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR92_RS13340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DR92_RS13345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DR92_RS13365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR92_RS13370	COG3938	Belongs to the proline racemase family
DR92_RS13410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DR92_RS13420	COG0738	Major facilitator superfamily
DR92_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS13430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DR92_RS13435	COG2814	Major facilitator Superfamily
DR92_RS13445	COG0142	geranyltranstransferase activity
DR92_RS13455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DR92_RS13465	COG0183	Belongs to the thiolase family
DR92_RS13480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DR92_RS13485	COG1329	Transcriptional regulator
DR92_RS13490	COG0583	DNA-binding transcription factor activity
DR92_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS13500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR92_RS13505	COG2258	MOSC domain
DR92_RS13525	COG4143	(ABC) transporter
DR92_RS13540	COG0488	(ABC) transporter
DR92_RS13545	COG0667	Aldo Keto reductase
DR92_RS13635	COG3750	Belongs to the UPF0335 family
DR92_RS13650	COG0469	pyruvate kinase activity
DR92_RS13655	COG0457	Tetratricopeptide repeat
DR92_RS13660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DR92_RS13665	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DR92_RS13670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DR92_RS13745	COG3588	fructose-bisphosphate aldolase
DR92_RS13750	COG2133	pyrroloquinoline quinone binding
DR92_RS13795	COG1692	metallophosphoesterase
DR92_RS13800	COG1253	flavin adenine dinucleotide binding
DR92_RS13810	COG1268	BioY protein
DR92_RS13820	COG0217	transcriptional regulatory protein
DR92_RS13830	COG1132	(ABC) transporter
DR92_RS13845	COG0483	inositol monophosphate 1-phosphatase activity
DR92_RS13875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DR92_RS13880	COG0632	four-way junction helicase activity
DR92_RS13885	COG2255	four-way junction helicase activity
DR92_RS13890	COG0824	Thioesterase
DR92_RS13900	COG0848	biopolymer transport protein
DR92_RS13910	COG0823	Involved in the tonB-independent uptake of proteins
DR92_RS13915	COG2885	chlorophyll binding
DR92_RS13925	COG0037	tRNA processing
DR92_RS13930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DR92_RS13935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR92_RS13950	COG0385	Bile acid
DR92_RS13960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR92_RS13970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DR92_RS13980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DR92_RS13985	COG4977	sequence-specific DNA binding
DR92_RS13995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR92_RS14000	COG0564	pseudouridine synthase activity
DR92_RS14045	COG0784	Response regulator, receiver
DR92_RS14060	COG3920	Histidine kinase
DR92_RS14085	COG0848	biopolymer transport protein
DR92_RS14095	COG3698	Phosphodiester glycosidase
DR92_RS14100	COG1136	(ABC) transporter
DR92_RS14100	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR92_RS14105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS14130	COG1522	sequence-specific DNA binding
DR92_RS14150	COG0477	Major facilitator Superfamily
DR92_RS14160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DR92_RS14165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR92_RS14190	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS14230	COG0583	DNA-binding transcription factor activity
DR92_RS14235	COG0667	Aldo Keto reductase
DR92_RS14250	COG2814	Major facilitator Superfamily
DR92_RS14255	COG2807	transmembrane transport
DR92_RS14260	COG0590	tRNA wobble adenosine to inosine editing
DR92_RS14270	COG0583	DNA-binding transcription factor activity
DR92_RS14275	COG1802	Transcriptional regulator
DR92_RS14300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS14310	COG4608	Belongs to the ABC transporter superfamily
DR92_RS14315	COG0154	amidase activity
DR92_RS14320	COG2176	DNA-directed DNA polymerase activity
DR92_RS14325	COG0579	oxidoreductase
DR92_RS14330	COG2199	diguanylate cyclase activity
DR92_RS14355	COG1476	TRANSCRIPTIONal
DR92_RS14405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR92_RS14415	COG2900	Belongs to the SlyX family
DR92_RS14425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DR92_RS14430	COG2226	methyltransferase
DR92_RS14435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DR92_RS14440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DR92_RS14450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DR92_RS14460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR92_RS14485	COG0778	Nitroreductase
DR92_RS14495	COG0588	phosphoglycerate mutase activity
DR92_RS14505	COG1132	(ABC) transporter
DR92_RS14515	COG1803	Methylglyoxal synthase
DR92_RS14520	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
DR92_RS14535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DR92_RS14545	COG1968	undecaprenyl-diphosphatase activity
DR92_RS14555	COG0481	GTPase activity
DR92_RS14575	COG0242	peptide deformylase activity
DR92_RS14580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DR92_RS14585	COG0101	tRNA pseudouridine synthase activity
DR92_RS14590	COG0604	alcohol dehydrogenase
DR92_RS14605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DR92_RS14630	COG2171	N-acyltransferase activity
DR92_RS14640	COG3739	integral membrane protein
DR92_RS14650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DR92_RS14660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DR92_RS14670	COG0594	ribonuclease P activity
DR92_RS14675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DR92_RS14685	COG0251	oxidation-reduction process
DR92_RS14695	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DR92_RS14700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DR92_RS14705	COG0400	carboxylic ester hydrolase activity
DR92_RS14710	COG3738	Protein conserved in bacteria
DR92_RS14725	COG0523	cobalamin synthesis protein
DR92_RS14740	COG1609	Transcriptional regulator
DR92_RS14745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DR92_RS14750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DR92_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS14760	COG5001	Diguanylate cyclase
DR92_RS14800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR92_RS14815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DR92_RS14830	COG2011	ABC-type metal ion transport system permease component
DR92_RS14840	COG1464	Belongs to the NlpA lipoprotein family
DR92_RS14855	COG0559	Belongs to the binding-protein-dependent transport system permease family
DR92_RS14880	COG0583	DNA-binding transcription factor activity
DR92_RS14895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR92_RS14900	COG1737	Transcriptional regulator
DR92_RS14905	COG2271	Major facilitator Superfamily
DR92_RS14915	COG0028	Belongs to the TPP enzyme family
DR92_RS14925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DR92_RS14935	COG2186	Transcriptional regulator
DR92_RS14940	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR92_RS14945	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR92_RS14950	COG1129	ABC transporter
DR92_RS14955	COG1879	ABC-type sugar transport system periplasmic component
DR92_RS14975	COG0129	dihydroxy-acid dehydratase activity
DR92_RS14980	COG3734	2-keto-3-deoxy-galactonokinase
DR92_RS14985	COG0800	Aldolase
DR92_RS14990	COG4213	ABC transporter substrate-binding protein
DR92_RS15000	COG4214	carbohydrate transport
DR92_RS15015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR92_RS15030	COG3314	Sporulation integral membrane protein YlbJ
DR92_RS15035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DR92_RS15045	COG2986	histidine ammonia-lyase
DR92_RS15050	COG1228	amidohydrolase
DR92_RS15055	COG0402	S-adenosylhomocysteine deaminase activity
DR92_RS15075	COG1595	DNA-templated transcription, initiation
DR92_RS15080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DR92_RS15090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR92_RS15100	COG1522	sequence-specific DNA binding
DR92_RS15115	COG0243	molybdopterin cofactor binding
DR92_RS15125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS15130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS15140	COG2188	Transcriptional regulator
DR92_RS15150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DR92_RS15155	COG4821	SIS domain
DR92_RS15165	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS15170	COG5383	Protein conserved in bacteria
DR92_RS15180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR92_RS15185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DR92_RS15195	COG3842	ATPase activity
DR92_RS15200	COG2183	response to ionizing radiation
DR92_RS15205	COG0640	Transcriptional regulator
DR92_RS15210	COG1902	pentaerythritol trinitrate reductase activity
DR92_RS15220	COG0010	Belongs to the arginase family
DR92_RS15245	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DR92_RS15255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DR92_RS15295	COG3180	Ammonia monooxygenase
DR92_RS15305	COG0745	RESPONSE REGULATOR receiver
DR92_RS15310	COG0784	Response regulator, receiver
DR92_RS15340	COG0482	sulfurtransferase activity
DR92_RS15365	COG0747	negative chemotaxis
DR92_RS15370	COG0601	transmembrane transport
DR92_RS15375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS15380	COG0444	Belongs to the ABC transporter superfamily
DR92_RS15385	COG4608	Belongs to the ABC transporter superfamily
DR92_RS15390	COG4175	Glycine betaine
DR92_RS15395	COG4176	ABC-type proline glycine betaine transport system permease component
DR92_RS15435	COG1522	sequence-specific DNA binding
DR92_RS15440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR92_RS15440	COG0512	Glutamine amidotransferase of anthranilate synthase
DR92_RS15450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DR92_RS15475	COG1051	belongs to the nudix hydrolase family
DR92_RS15480	COG3047	cAMP biosynthetic process
DR92_RS15485	COG0435	Glutathione S-transferase
DR92_RS15510	COG0714	Associated with various cellular activities
DR92_RS15525	COG0617	tRNA 3'-terminal CCA addition
DR92_RS15535	COG3811	Belongs to the UPF0386 family
DR92_RS15545	COG0408	coproporphyrinogen oxidase activity
DR92_RS15565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DR92_RS15570	COG1132	(ABC) transporter
DR92_RS15575	COG1132	(ABC) transporter
DR92_RS15590	COG2857	Cytochrome c1
DR92_RS15590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DR92_RS15595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DR92_RS15610	COG0012	GTP binding
DR92_RS15620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DR92_RS15635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DR92_RS15645	COG0006	proline dipeptidase activity
DR92_RS15650	COG1496	oxidoreductase activity
DR92_RS15660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DR92_RS15675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR92_RS15680	COG2205	protein histidine kinase activity
DR92_RS15685	COG0745	RESPONSE REGULATOR receiver
DR92_RS15690	COG1846	Transcriptional regulator
DR92_RS15700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DR92_RS15710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DR92_RS15720	COG1278	Cold shock
DR92_RS15725	COG1196	nuclear chromosome segregation
DR92_RS15725	COG0741	lytic transglycosylase activity
DR92_RS15725	COG0739	heme binding
DR92_RS15735	COG0556	nucleotide-excision repair
DR92_RS15745	COG1607	acyl-coa hydrolase
DR92_RS15770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR92_RS15780	COG1522	sequence-specific DNA binding
DR92_RS15785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR92_RS15790	COG0492	ferredoxin-NADP+ reductase activity
DR92_RS15795	COG0583	DNA-binding transcription factor activity
DR92_RS15800	COG1653	transport
DR92_RS15805	COG3833	ABC-type maltose transport systems, permease component
DR92_RS15810	COG1175	transmembrane transport
DR92_RS15830	COG0436	Aminotransferase
DR92_RS15840	COG0702	epimerase
DR92_RS15850	COG1278	Cold shock
DR92_RS15860	COG1136	(ABC) transporter
DR92_RS15870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR92_RS15875	COG2321	neutral zinc metallopeptidase
DR92_RS15885	COG0505	Belongs to the CarA family
DR92_RS15890	COG1610	YqeY-like protein
DR92_RS15900	COG0358	DNA primase activity
DR92_RS15905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR92_RS15930	COG2968	Membrane
DR92_RS15950	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DR92_RS16010	COG1335	isochorismatase
DR92_RS16015	COG2824	Alkylphosphonate utilization operon protein PhnA
DR92_RS16020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR92_RS16035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DR92_RS16050	COG2267	carboxylic ester hydrolase activity
DR92_RS16060	COG4106	trans-aconitate 2-methyltransferase activity
DR92_RS16065	COG0477	Major facilitator Superfamily
DR92_RS16075	COG0640	Transcriptional regulator
DR92_RS16100	COG4106	trans-aconitate 2-methyltransferase activity
DR92_RS16120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DR92_RS16125	COG3023	N-Acetylmuramoyl-L-alanine amidase
DR92_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS16145	COG1914	H( )-stimulated, divalent metal cation uptake system
DR92_RS16150	COG0275	rRNA processing
DR92_RS16175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR92_RS16190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DR92_RS16195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DR92_RS16200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DR92_RS16205	COG1181	Belongs to the D-alanine--D-alanine ligase family
DR92_RS16210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DR92_RS16215	COG0849	cell division
DR92_RS16220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DR92_RS16230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR92_RS16240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DR92_RS16260	COG0006	proline dipeptidase activity
DR92_RS16270	COG1999	signal sequence binding
DR92_RS16290	COG0210	DNA helicase
DR92_RS16300	COG4702	Belongs to the UPF0303 family
DR92_RS16305	COG0277	FAD linked oxidase domain protein
DR92_RS16335	COG2814	Major facilitator Superfamily
DR92_RS16430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DR92_RS16445	COG0330	HflC and HflK could
DR92_RS16455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR92_RS16460	COG2081	HI0933 family
DR92_RS16470	COG0560	Phosphoserine phosphatase
DR92_RS16475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DR92_RS16480	COG3706	GGDEF domain
DR92_RS16490	COG0028	Belongs to the TPP enzyme family
DR92_RS16495	COG0440	acetolactate synthase activity
DR92_RS16510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR92_RS16520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DR92_RS16525	COG3158	transport of potassium into the cell
DR92_RS16535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DR92_RS16545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR92_RS16565	COG0384	phenazine biosynthesis protein PhzF
DR92_RS16580	COG1649	PFAM Uncharacterised BCR, COG1649
DR92_RS16585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS16590	COG1129	ABC transporter
DR92_RS16590	COG0842	Transport permease protein
DR92_RS16595	COG0842	Transport permease protein
DR92_RS16600	COG4206	TonB-dependent receptor
DR92_RS16610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR92_RS16615	COG1120	ATPase activity
DR92_RS16620	COG0673	inositol 2-dehydrogenase activity
DR92_RS16665	COG4608	Belongs to the ABC transporter superfamily
DR92_RS16670	COG0601	transmembrane transport
DR92_RS16675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS16680	COG4154	Belongs to the RbsD FucU family
DR92_RS16740	COG0586	Pfam SNARE associated Golgi protein
DR92_RS16745	COG1253	flavin adenine dinucleotide binding
DR92_RS16760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DR92_RS16765	COG4208	sulfate ABC transporter
DR92_RS16780	COG4651	solute:proton antiporter activity
DR92_RS16780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR92_RS16795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DR92_RS16795	COG3264	Mechanosensitive ion channel
DR92_RS16820	COG0583	DNA-binding transcription factor activity
DR92_RS16830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DR92_RS16845	COG1492	cobalamin metabolic process
DR92_RS16905	COG1309	transcriptional regulator
DR92_RS16920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DR92_RS16930	COG1797	cobyrinic acid a,c-diamide synthase activity
DR92_RS16940	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DR92_RS16950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DR92_RS16995	COG4608	Belongs to the ABC transporter superfamily
DR92_RS17005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS17010	COG0601	transmembrane transport
DR92_RS17020	COG0747	negative chemotaxis
DR92_RS17035	COG2003	Belongs to the UPF0758 family
DR92_RS17040	COG0024	Methionine aminopeptidase
DR92_RS17045	COG1489	DNA binding
DR92_RS17075	COG0436	Aminotransferase
DR92_RS17085	COG0488	(ABC) transporter
DR92_RS17090	COG1494	fructose-1,6-bisphosphatase
DR92_RS17110	COG1278	Cold shock
DR92_RS17190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR92_RS17205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DR92_RS17215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR92_RS17225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DR92_RS17230	COG0081	regulation of translation
DR92_RS17235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DR92_RS17240	COG0222	ribosome binding
DR92_RS17245	COG0085	RNA polymerase activity
DR92_RS17250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DR92_RS17260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DR92_RS17265	COG0049	tRNA binding
DR92_RS17270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR92_RS17275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DR92_RS17285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DR92_RS17290	COG0088	Forms part of the polypeptide exit tunnel
DR92_RS17295	COG0089	rRNA binding
DR92_RS17300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DR92_RS17305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DR92_RS17315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DR92_RS17320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DR92_RS17330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DR92_RS17340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DR92_RS17345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DR92_RS17350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DR92_RS17355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DR92_RS17360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DR92_RS17365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DR92_RS17370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DR92_RS17380	COG0200	Binds to the 23S rRNA
DR92_RS17390	COG0563	adenylate kinase activity
DR92_RS17395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DR92_RS17405	COG0202	RNA polymerase activity
DR92_RS17410	COG0203	ribosomal protein L17
DR92_RS17415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR92_RS17420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DR92_RS17430	COG2885	chlorophyll binding
DR92_RS17435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR92_RS17440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DR92_RS17465	COG0538	isocitrate dehydrogenase activity
DR92_RS17475	COG0693	protein deglycase activity
DR92_RS17480	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DR92_RS17485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DR92_RS17490	COG0656	L-ascorbic acid biosynthetic process
DR92_RS17510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DR92_RS17510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DR92_RS17515	COG4770	biotin carboxylase activity
DR92_RS17520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR92_RS17525	COG1396	sequence-specific DNA binding
DR92_RS17525	COG3800	Transcriptional regulator
DR92_RS17535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DR92_RS17575	COG1760	l-serine dehydratase
DR92_RS17590	COG1686	Belongs to the peptidase S11 family
DR92_RS17615	COG0537	adenosine 5'-monophosphoramidase activity
DR92_RS17640	COG0052	Belongs to the universal ribosomal protein uS2 family
DR92_RS17645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DR92_RS17650	COG0528	UMP kinase activity
DR92_RS17655	COG0233	cytoplasmic translational termination
DR92_RS17675	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR92_RS17685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DR92_RS17690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR92_RS17700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR92_RS17705	COG0372	Belongs to the citrate synthase family
DR92_RS17710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR92_RS17715	COG2333	competence protein COMEC
DR92_RS17715	COG0658	competence protein
DR92_RS17720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR92_RS17725	COG0303	'Molybdopterin
DR92_RS17730	COG0315	cyclic pyranopterin monophosphate synthase activity
DR92_RS17735	COG0134	indole-3-glycerol-phosphate synthase activity
DR92_RS17740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DR92_RS17745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR92_RS17765	COG0504	CTP synthase activity
DR92_RS17770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DR92_RS17775	COG0148	phosphopyruvate hydratase activity
DR92_RS17780	COG5507	3-demethylubiquinone-9 3-methyltransferase
DR92_RS17785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DR92_RS17790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DR92_RS17795	COG0022	dehydrogenase e1 component
DR92_RS17795	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR92_RS17800	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR92_RS17810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR92_RS17820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DR92_RS17825	COG2867	negative regulation of translational initiation
DR92_RS17830	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS17835	COG1058	Belongs to the CinA family
DR92_RS17835	COG1546	Belongs to the CinA family
DR92_RS17840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DR92_RS17840	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DR92_RS17850	COG3852	Histidine kinase
DR92_RS17855	COG2204	response regulator
DR92_RS17875	COG1597	lipid kinase activity
DR92_RS17905	COG0084	hydrolase, TatD family'
DR92_RS17940	COG0174	glutamine synthetase
DR92_RS17945	COG0347	Belongs to the P(II) protein family
DR92_RS17950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DR92_RS17950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DR92_RS17960	COG0546	phosphoglycolate phosphatase activity
DR92_RS17980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DR92_RS17985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR92_RS17995	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DR92_RS17995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR92_RS18000	COG0281	malic enzyme
DR92_RS18000	COG0280	phosphate acetyltransferase
DR92_RS18005	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS18015	COG0372	Belongs to the citrate synthase family
DR92_RS18025	COG0438	transferase activity, transferring glycosyl groups
DR92_RS18030	COG4948	Mandelate Racemase Muconate Lactonizing
DR92_RS18035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DR92_RS18040	COG1127	ABC transporter
DR92_RS18065	COG0633	Ferredoxin
DR92_RS18070	COG0492	ferredoxin-NADP+ reductase activity
DR92_RS18080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR92_RS18090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR92_RS18100	COG3768	UPF0283 membrane protein
DR92_RS18105	COG3106	COG3106 Predicted ATPase
DR92_RS18130	COG2081	HI0933 family
DR92_RS18140	COG2072	flavoprotein involved in K transport
DR92_RS18155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR92_RS18165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DR92_RS18175	COG1546	Belongs to the CinA family
DR92_RS18175	COG1058	Belongs to the CinA family
DR92_RS18180	COG0655	NAD(P)H dehydrogenase (quinone) activity
DR92_RS18185	COG0668	transmembrane transport
DR92_RS18195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DR92_RS18200	COG0513	Belongs to the DEAD box helicase family
DR92_RS18205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DR92_RS18210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DR92_RS18215	COG2897	thiosulfate sulfurtransferase activity
DR92_RS18230	COG0427	acetyl-CoA hydrolase
DR92_RS18240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR92_RS18250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR92_RS18255	COG3956	TIGRFAM MazG family protein
DR92_RS18260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DR92_RS18280	COG1686	Belongs to the peptidase S11 family
DR92_RS18285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DR92_RS18295	COG0302	gtp cyclohydrolase
DR92_RS18300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DR92_RS18305	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR92_RS18375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DR92_RS18380	COG1960	acyl-CoA dehydrogenase activity
DR92_RS18385	COG0583	DNA-binding transcription factor activity
DR92_RS18390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DR92_RS18395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR92_RS18400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS18410	COG0343	queuine tRNA-ribosyltransferase activity
DR92_RS18415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DR92_RS18430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DR92_RS18435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DR92_RS18440	COG2095	MarC family integral membrane protein
DR92_RS18445	COG3639	organic phosphonate transmembrane transporter activity
DR92_RS18450	COG3639	organic phosphonate transmembrane transporter activity
DR92_RS18455	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DR92_RS18460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DR92_RS18470	COG3454	Phosphonate metabolism
DR92_RS18480	COG4778	phosphonate C-P lyase system protein PhnL
DR92_RS18485	COG4107	phosphonate C-P lyase system protein PhnK
DR92_RS18490	COG3627	carbon phosphorus lyase activity
DR92_RS18495	COG3626	phosphonate metabolism
DR92_RS18505	COG3624	Phosphonate C-P lyase system protein PhnG
DR92_RS18510	COG2188	Transcriptional regulator
DR92_RS18515	COG1393	Belongs to the ArsC family
DR92_RS18530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DR92_RS18535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR92_RS18560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DR92_RS18570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DR92_RS18580	COG0569	domain protein
DR92_RS18585	COG2204	response regulator
DR92_RS18590	COG5000	phosphorelay sensor kinase activity
DR92_RS18600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR92_RS18610	COG0463	Glycosyl transferase, family 2
DR92_RS18610	COG1216	Glycosyl transferase, family 2
DR92_RS18620	COG0488	(ABC) transporter
DR92_RS18655	COG2989	Protein conserved in bacteria
DR92_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS18670	COG1309	transcriptional regulator
DR92_RS18710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR92_RS18725	COG0625	glutathione transferase activity
DR92_RS18730	COG2084	Dehydrogenase
DR92_RS18755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DR92_RS18770	COG0316	Belongs to the HesB IscA family
DR92_RS18780	COG0513	Belongs to the DEAD box helicase family
DR92_RS18795	COG2151	metal-sulfur cluster biosynthetic enzyme
DR92_RS18800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DR92_RS18805	COG0719	Fe-S assembly protein
DR92_RS18810	COG0396	ATPase activity
DR92_RS18815	COG0719	Fe-S assembly protein
DR92_RS18830	COG2945	thiolester hydrolase activity
DR92_RS18850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DR92_RS18855	COG2833	Protein of unknown function (DUF455)
DR92_RS18860	COG1196	nuclear chromosome segregation
DR92_RS18860	COG0741	lytic transglycosylase activity
DR92_RS18860	COG0739	heme binding
DR92_RS18870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DR92_RS18875	COG0860	N-Acetylmuramoyl-L-alanine amidase
DR92_RS18885	COG1530	ribonuclease E activity
DR92_RS18890	COG0436	Aminotransferase
DR92_RS18910	COG0511	ligase activity, forming carbon-carbon bonds
DR92_RS18915	COG0439	Biotin carboxylase
DR92_RS18920	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DR92_RS18925	COG4765	Protein conserved in bacteria
DR92_RS18940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DR92_RS18945	COG0544	peptidyl-prolyl cis-trans isomerase activity
DR92_RS18965	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DR92_RS18985	COG1862	Preprotein translocase
DR92_RS19000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DR92_RS19005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DR92_RS19015	COG0805	protein transport
DR92_RS19020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR92_RS19025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR92_RS19030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DR92_RS19035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DR92_RS19040	COG1472	Belongs to the glycosyl hydrolase 3 family
DR92_RS19050	COG0018	arginyl-trna synthetase
DR92_RS19055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DR92_RS19060	COG0316	Belongs to the HesB IscA family
DR92_RS19085	COG1573	uracil-dna glycosylase
DR92_RS19090	COG1522	sequence-specific DNA binding
DR92_RS19095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DR92_RS19100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DR92_RS19120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR92_RS19125	COG3454	Phosphonate metabolism
DR92_RS19130	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DR92_RS19135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR92_RS19140	COG2017	converts alpha-aldose to the beta-anomer
DR92_RS19150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DR92_RS19155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR92_RS19160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR92_RS19180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DR92_RS19185	COG2514	catechol 2,3-dioxygenase activity
DR92_RS19205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DR92_RS19210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR92_RS19235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR92_RS19240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR92_RS19250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DR92_RS19255	COG2814	Major facilitator Superfamily
DR92_RS19260	COG0483	inositol monophosphate 1-phosphatase activity
DR92_RS19265	COG0037	tRNA processing
DR92_RS19275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DR92_RS19295	COG1733	regulation of RNA biosynthetic process
DR92_RS19300	COG2910	NAD(P)H-binding
DR92_RS19320	COG0442	prolyl-tRNA aminoacylation
DR92_RS19330	COG0346	lactoylglutathione lyase activity
DR92_RS19345	COG1007	ATP synthesis coupled electron transport
DR92_RS19360	COG0713	ATP synthesis coupled electron transport
DR92_RS19370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DR92_RS19375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DR92_RS19385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DR92_RS19390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DR92_RS19395	COG0649	NAD binding
DR92_RS19405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DR92_RS19410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DR92_RS19415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DR92_RS19440	COG1309	transcriptional regulator
DR92_RS19455	COG2358	TRAP transporter, solute receptor (TAXI family
DR92_RS19460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DR92_RS19465	COG4574	serine-type endopeptidase inhibitor activity
DR92_RS19490	COG1285	pathogenesis
DR92_RS19495	COG2610	gluconate transmembrane transporter activity
DR92_RS19505	COG0830	nickel cation binding
DR92_RS19510	COG4413	Urea transporter
DR92_RS19520	COG0832	Belongs to the urease beta subunit family
DR92_RS19525	COG0831	urea catabolic process
DR92_RS19530	COG0829	nickel cation binding
DR92_RS19590	COG2116	formate transmembrane transporter activity
DR92_RS19605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS19610	COG0601	transmembrane transport
DR92_RS19625	COG4172	Belongs to the ABC transporter superfamily
DR92_RS19635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR92_RS19640	COG3842	ATPase activity
DR92_RS19645	COG0165	Argininosuccinate lyase
DR92_RS19655	COG1175	transmembrane transport
DR92_RS19665	COG1940	carbohydrate kinase activity
DR92_RS19700	COG1832	CoA-binding protein
DR92_RS19710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DR92_RS19715	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DR92_RS19720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DR92_RS19725	COG2329	Antibiotic biosynthesis monooxygenase
DR92_RS19730	COG0010	Belongs to the arginase family
DR92_RS19735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DR92_RS19745	COG1612	heme a metabolic process
DR92_RS19770	COG0438	transferase activity, transferring glycosyl groups
DR92_RS19790	COG1742	UPF0060 membrane protein
DR92_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS19810	COG0356	it plays a direct role in the translocation of protons across the membrane
DR92_RS19825	COG0776	regulation of translation
DR92_RS19830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DR92_RS19835	COG0416	fatty acid biosynthetic process
DR92_RS19855	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DR92_RS19865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR92_RS19880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR92_RS19880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR92_RS19885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DR92_RS19890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DR92_RS19895	COG2989	Protein conserved in bacteria
DR92_RS19920	COG0113	porphobilinogen synthase activity
DR92_RS19930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DR92_RS19945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DR92_RS19955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DR92_RS19960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DR92_RS19970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DR92_RS19995	COG1733	regulation of RNA biosynthetic process
DR92_RS20005	COG0640	Transcriptional regulator
DR92_RS20020	COG1126	abc transporter atp-binding protein
DR92_RS20025	COG0765	amino acid transport
DR92_RS20030	COG4597	amino acid ABC transporter
DR92_RS20035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR92_RS20045	COG0671	phosphoesterase, PA-phosphatase related
DR92_RS20050	COG0626	cystathionine gamma-synthase activity
DR92_RS20055	COG0628	permease
DR92_RS20095	COG1278	Cold shock
DR92_RS20140	COG3685	Protein conserved in bacteria
DR92_RS20145	COG2801	Transposase and inactivated derivatives
DR92_RS20150	COG2963	transposase activity
DR92_RS20155	COG2963	transposase activity
DR92_RS20160	COG2801	Transposase and inactivated derivatives
DR92_RS20210	COG0628	permease
DR92_RS20215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DR92_RS20220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DR92_RS20230	COG0243	molybdopterin cofactor binding
DR92_RS20240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DR92_RS20285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DR92_RS20290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DR92_RS20295	COG0314	molybdopterin synthase activity
DR92_RS20300	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DR92_RS20305	COG0105	UTP biosynthetic process
DR92_RS20315	COG0488	(ABC) transporter
DR92_RS20335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DR92_RS20350	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DR92_RS20355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR92_RS20360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DR92_RS20365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DR92_RS20370	COG0739	heme binding
DR92_RS20380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DR92_RS20390	COG0215	cysteine-tRNA ligase activity
DR92_RS20405	COG0494	nUDIX hydrolase
DR92_RS20440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DR92_RS20450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DR92_RS20475	COG0681	Belongs to the peptidase S26 family
DR92_RS20490	COG2207	Transcriptional regulator
DR92_RS20500	COG2223	nitrite transmembrane transporter activity
DR92_RS20505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DR92_RS20510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR92_RS20515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DR92_RS20525	COG1758	RNA polymerase activity
DR92_RS20535	COG1573	uracil-dna glycosylase
DR92_RS20540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DR92_RS20550	COG0741	lytic transglycosylase activity
DR92_RS20555	COG3743	rRNA binding
DR92_RS20555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DR92_RS20585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DR92_RS20620	COG0625	glutathione transferase activity
DR92_RS20625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR92_RS20630	COG3021	interspecies interaction between organisms
DR92_RS20640	COG1573	uracil-dna glycosylase
DR92_RS20655	COG0308	aminopeptidase N
DR92_RS20660	COG2205	protein histidine kinase activity
DR92_RS20660	COG2202	Pas domain
DR92_RS20665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DR92_RS20670	COG2205	protein histidine kinase activity
DR92_RS20675	COG0745	RESPONSE REGULATOR receiver
DR92_RS20685	COG3088	subunit of a heme lyase
DR92_RS20690	COG1138	Cytochrome C-type biogenesis protein
DR92_RS20695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
DR92_RS20700	COG4235	cytochrome complex assembly
DR92_RS20735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DR92_RS20765	COG2205	protein histidine kinase activity
DR92_RS20775	COG2166	iron-sulfur cluster assembly
DR92_RS20780	COG0154	amidase activity
DR92_RS20790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DR92_RS20800	COG4957	zinc ion binding
DR92_RS20815	COG0318	PFAM AMP-dependent synthetase and ligase
DR92_RS20825	COG3909	cytochrome
DR92_RS20830	COG2010	Cytochrome c
DR92_RS20835	COG0433	COG0433 Predicted ATPase
DR92_RS20845	COG1376	ErfK ybiS ycfS ynhG family protein
DR92_RS20855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DR92_RS20860	COG2807	transmembrane transport
DR92_RS20865	COG2186	Transcriptional regulator
DR92_RS20885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR92_RS20890	COG1309	transcriptional regulator
DR92_RS20895	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DR92_RS20900	COG1012	belongs to the aldehyde dehydrogenase family
DR92_RS20910	COG2801	Transposase and inactivated derivatives
DR92_RS20915	COG2963	transposase activity
DR92_RS20920	COG2207	Transcriptional regulator
DR92_RS20925	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DR92_RS20930	COG1877	trehalose-phosphatase activity
DR92_RS20940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR92_RS20945	COG1091	dTDP-4-dehydrorhamnose reductase activity
DR92_RS20950	COG1088	dTDP-glucose 4,6-dehydratase activity
DR92_RS20980	COG3293	Transposase
DR92_RS20995	COG2963	transposase activity
DR92_RS21005	COG4372	Transposase
DR92_RS21025	COG1484	DNA-dependent DNA replication
DR92_RS21030	COG4584	PFAM Integrase catalytic
DR92_RS21030	COG2390	Transcriptional regulator
DR92_RS21040	COG2963	transposase activity
DR92_RS21045	COG3344	reverse transcriptase
DR92_RS21110	COG2801	Transposase and inactivated derivatives
DR92_RS21155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR92_RS21170	COG2351	hydroxyisourate hydrolase activity
DR92_RS21175	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DR92_RS21180	COG1268	BioY protein
DR92_RS21195	COG3258	Cytochrome c
DR92_RS21215	COG0574	Belongs to the PEP-utilizing enzyme family
DR92_RS21215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR92_RS21220	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
DR92_RS21225	COG2948	multi-organism process
DR92_RS21230	COG3504	Conjugal transfer protein
DR92_RS21235	COG3736	Type IV secretory pathway, component VirB8
DR92_RS21240	COG3704	protein secretion by the type IV secretion system
DR92_RS21255	COG3451	type IV secretory pathway VirB4
DR92_RS21260	COG3702	type iv secretory pathway
DR92_RS21265	COG3838	Conjugal transfer protein Trbc
DR92_RS21285	COG2197	response regulator
DR92_RS21295	COG1476	TRANSCRIPTIONal
DR92_RS21340	COG4372	Transposase
DR92_RS21355	COG4372	Transposase
DR92_RS21370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DR92_RS21405	COG3505	Type IV secretory pathway VirD4
DR92_RS21430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR92_RS21445	COG1175	transmembrane transport
DR92_RS21450	COG0395	ABC-type sugar transport system, permease component
DR92_RS21470	COG3093	addiction module antidote protein HigA
DR92_RS21475	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
DR92_RS21495	COG2362	D-Aminopeptidase
DR92_RS21500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR92_RS21510	COG0747	negative chemotaxis
DR92_RS21515	COG4172	Belongs to the ABC transporter superfamily
DR92_RS21555	COG3177	Filamentation induced by cAMP protein fic
DR92_RS21570	COG1196	nuclear chromosome segregation
DR92_RS21600	COG1194	a g-specific adenine glycosylase
DR92_RS21610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
DR92_RS21620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR92_RS21645	COG0612	Peptidase, M16
DR92_RS21650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR92_RS21670	COG0678	peroxiredoxin activity
DR92_RS21675	COG0328	RNA-DNA hybrid ribonuclease activity
DR92_RS21680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DR92_RS21685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DR92_RS21690	COG3346	SURF1 family
DR92_RS21705	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DR92_RS21715	COG0109	protoheme IX farnesyltransferase activity
DR92_RS21720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DR92_RS21735	COG0312	modulator of DNA gyrase
DR92_RS21750	COG0194	GDP metabolic process
DR92_RS21755	COG1561	YicC-like family, N-terminal region
DR92_RS21760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DR92_RS21765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR92_RS21780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DR92_RS21785	COG0360	Binds together with S18 to 16S ribosomal RNA
DR92_RS21790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DR92_RS21800	COG0359	binds to the 23S rRNA
DR92_RS21805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR92_RS21815	COG0305	Participates in initiation and elongation during chromosome replication
DR92_RS21830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DR92_RS21835	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS21845	COG1183	phosphatidylcholine synthase activity
DR92_RS21850	COG0688	phosphatidylethanolamine metabolic process
DR92_RS21855	COG5265	(ABC) transporter
DR92_RS21880	COG1794	racemase activity, acting on amino acids and derivatives
DR92_RS21895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DR92_RS21900	COG1741	Belongs to the pirin family
DR92_RS21910	COG2261	transglycosylase associated protein
DR92_RS21920	COG1722	exodeoxyribonuclease VII activity
DR92_RS21925	COG0123	including yeast histone deacetylase and acetoin utilization protein
DR92_RS21930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR92_RS21930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR92_RS21935	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DR92_RS21955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR92_RS21960	COG0484	heat shock protein binding
DR92_RS21975	COG0259	pyridoxamine-phosphate oxidase activity
DR92_RS21980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DR92_RS21990	COG1960	acyl-CoA dehydrogenase activity
DR92_RS22010	COG0009	L-threonylcarbamoyladenylate synthase
DR92_RS22020	COG0751	glycine-tRNA ligase activity
DR92_RS22025	COG0752	glycyl-tRNA synthetase alpha subunit
DR92_RS22035	COG0142	geranyltranstransferase activity
DR92_RS22055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DR92_RS22095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DR92_RS22105	COG1522	sequence-specific DNA binding
DR92_RS22110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DR92_RS22115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DR92_RS22125	COG0356	it plays a direct role in the translocation of protons across the membrane
DR92_RS22135	COG3773	Cell wall hydrolase
DR92_RS22180	COG1160	GTP binding
DR92_RS22195	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DR92_RS22200	COG0477	Major facilitator Superfamily
DR92_RS22220	COG0740	serine-type endopeptidase activity
DR92_RS22230	COG1393	Belongs to the ArsC family
DR92_RS22240	COG2169	Transcriptional regulator
DR92_RS22240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DR92_RS22250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DR92_RS22250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR92_RS22255	COG1376	ErfK ybiS ycfS ynhG family protein
DR92_RS22260	COG4232	protein-disulfide reductase activity
DR92_RS22270	COG0642	Histidine kinase
DR92_RS22320	COG2084	Dehydrogenase
DR92_RS22325	COG3622	Belongs to the hyi family
DR92_RS22330	COG3960	tartronate-semialdehyde synthase activity
DR92_RS22335	COG1414	Transcriptional regulator
DR92_RS22340	COG0402	S-adenosylhomocysteine deaminase activity
DR92_RS22350	COG0583	DNA-binding transcription factor activity
DR92_RS22360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DR92_RS22365	COG2080	2 iron, 2 sulfur cluster binding
DR92_RS22370	COG2351	hydroxyisourate hydrolase activity
DR92_RS22375	COG3648	Uricase
DR92_RS22375	COG3195	allantoin biosynthetic process
DR92_RS22380	COG3257	ureidoglycine aminohydrolase activity
DR92_RS22390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DR92_RS22395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DR92_RS22425	COG3938	Belongs to the proline racemase family
DR92_RS22435	COG0019	diaminopimelate decarboxylase activity
DR92_RS22460	COG1309	transcriptional regulator
DR92_RS22475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR92_RS22480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DR92_RS22495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DR92_RS22510	COG0346	lactoylglutathione lyase activity
DR92_RS22520	COG1346	cytolysis
DR92_RS22525	COG1380	Effector of murein hydrolase LrgA
DR92_RS22530	COG0583	DNA-binding transcription factor activity
DR92_RS22565	COG0156	8-amino-7-oxononanoate synthase activity
DR92_RS22570	COG0436	Aminotransferase
DR92_RS22575	COG1970	mechanosensitive ion channel activity
DR92_RS22580	COG0784	Response regulator, receiver
DR92_RS22580	COG2205	protein histidine kinase activity
DR92_RS22605	COG0167	dihydroorotate dehydrogenase activity
DR92_RS22610	COG0534	Mate efflux family protein
DR92_RS22630	COG0717	Belongs to the dCTP deaminase family
DR92_RS22640	COG2967	ApaG domain
DR92_RS22655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DR92_RS22665	COG0438	transferase activity, transferring glycosyl groups
DR92_RS22670	COG0297	glycogen (starch) synthase activity
DR92_RS22680	COG3307	-O-antigen
DR92_RS22705	COG0463	Glycosyl transferase, family 2
DR92_RS22715	COG5002	protein histidine kinase activity
DR92_RS22720	COG2326	polyphosphate kinase activity
DR92_RS22730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR92_RS22750	COG0318	PFAM AMP-dependent synthetase and ligase
DR92_RS22770	COG0166	Belongs to the GPI family
DR92_RS22780	COG0697	spore germination
DR92_RS22785	COG0493	'glutamate synthase
DR92_RS22795	COG3842	ATPase activity
DR92_RS22800	COG3833	ABC-type maltose transport systems, permease component
DR92_RS22805	COG1175	transmembrane transport
DR92_RS22820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR92_RS22825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR92_RS22835	COG2186	Transcriptional regulator
DR92_RS22840	COG0626	cystathionine gamma-synthase activity
DR92_RS22855	COG0395	ABC-type sugar transport system, permease component
DR92_RS22860	COG3842	ATPase activity
DR92_RS22865	COG0494	nUDIX hydrolase
DR92_RS22870	COG1309	transcriptional regulator
DR92_RS22890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR92_RS22895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR92_RS22900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR92_RS22905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR92_RS22910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR92_RS22915	COG4191	Histidine kinase
DR92_RS22925	COG0415	Belongs to the DNA photolyase family
DR92_RS22930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DR92_RS22935	COG0830	nickel cation binding
DR92_RS22965	COG0829	nickel cation binding
DR92_RS23000	COG5328	Belongs to the UPF0262 family
DR92_RS23020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DR92_RS23035	COG4948	Mandelate Racemase Muconate Lactonizing
DR92_RS23045	COG1028	Short-chain dehydrogenase reductase Sdr
DR92_RS23060	COG3254	rhamnose metabolic process
DR92_RS23065	COG4948	Mandelate Racemase Muconate Lactonizing
DR92_RS23070	COG3842	ATPase activity
DR92_RS23075	COG0395	ABC-type sugar transport system, permease component
DR92_RS23080	COG1175	transmembrane transport
DR92_RS23090	COG1414	Transcriptional regulator
DR92_RS23095	COG3618	amidohydrolase
DR92_RS23200	COG0668	transmembrane transport
DR92_RS23210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR92_RS23215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins