locus-tag	class	description
IR196_RS00005	COG1192	Involved in chromosome partitioning
IR196_RS00010	COG1475	DNA binding
IR196_RS00015	COG1414	Transcriptional regulator
IR196_RS00030	COG2814	Major facilitator Superfamily
IR196_RS00055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS00060	COG1957	nucleoside hydrolase
IR196_RS00070	COG1079	Belongs to the binding-protein-dependent transport system permease family
IR196_RS00080	COG3845	ABC transporter
IR196_RS00085	COG1744	ABC transporter substrate-binding protein PnrA-like
IR196_RS00095	COG3842	ATPase activity
IR196_RS00100	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS00105	COG1177	transmembrane transport
IR196_RS00135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IR196_RS00140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR196_RS00145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR196_RS00150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IR196_RS00150	COG1082	Xylose isomerase domain protein TIM barrel
IR196_RS00155	COG1309	transcriptional regulator
IR196_RS00160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IR196_RS00170	COG0559	Belongs to the binding-protein-dependent transport system permease family
IR196_RS00200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR196_RS00215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IR196_RS00255	COG2195	Cleaves the N-terminal amino acid of tripeptides
IR196_RS00260	COG0747	negative chemotaxis
IR196_RS00265	COG0583	DNA-binding transcription factor activity
IR196_RS00270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR196_RS00275	COG1917	Cupin 2, conserved barrel domain protein
IR196_RS00295	COG1131	(ABC) transporter
IR196_RS00305	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IR196_RS00315	COG0583	DNA-binding transcription factor activity
IR196_RS00345	COG0714	Associated with various cellular activities
IR196_RS00350	COG3256	nitric oxide reductase
IR196_RS00365	COG1845	cytochrome c oxidase, subunit III
IR196_RS00395	COG2151	metal-sulfur cluster biosynthetic enzyme
IR196_RS00415	COG0626	cystathionine gamma-synthase activity
IR196_RS00425	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS00435	COG1129	ABC transporter
IR196_RS00445	COG2376	Dihydroxyacetone kinase
IR196_RS00460	COG0702	epimerase
IR196_RS00465	COG1073	alpha beta
IR196_RS00470	COG0583	DNA-binding transcription factor activity
IR196_RS00475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS00485	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS00500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR196_RS00510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR196_RS00515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IR196_RS00520	COG1959	2 iron, 2 sulfur cluster binding
IR196_RS00530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR196_RS00535	COG1473	amidohydrolase
IR196_RS00545	COG1126	abc transporter atp-binding protein
IR196_RS00550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS00585	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IR196_RS00600	COG0582	viral genome integration into host DNA
IR196_RS00610	COG2116	formate transmembrane transporter activity
IR196_RS00615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR196_RS00620	COG0210	DNA helicase
IR196_RS00645	COG1204	response to ionizing radiation
IR196_RS00670	COG0655	NAD(P)H dehydrogenase (quinone) activity
IR196_RS00680	COG0702	epimerase
IR196_RS00690	COG1476	TRANSCRIPTIONal
IR196_RS00700	COG3152	Membrane
IR196_RS00755	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IR196_RS00765	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IR196_RS00770	COG3920	Histidine kinase
IR196_RS00770	COG2202	Pas domain
IR196_RS00810	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS00830	COG1573	uracil-dna glycosylase
IR196_RS00930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR196_RS00965	COG0071	Belongs to the small heat shock protein (HSP20) family
IR196_RS00975	COG0070	glutamate synthase
IR196_RS00975	COG0069	glutamate synthase activity
IR196_RS00975	COG0067	glutamate synthase
IR196_RS00985	COG1113	amino acid transport
IR196_RS00995	COG2951	lytic endotransglycosylase activity
IR196_RS01000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IR196_RS01025	COG0330	HflC and HflK could
IR196_RS01030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IR196_RS01045	COG5310	Homospermidine synthase
IR196_RS01065	COG2204	response regulator
IR196_RS01070	COG3108	Peptidase M15
IR196_RS01075	COG0800	Aldolase
IR196_RS01085	COG1054	Belongs to the UPF0176 family
IR196_RS01090	COG0725	ABC transporter, periplasmic molybdate-binding protein
IR196_RS01095	COG4149	molybdate abc transporter
IR196_RS01100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IR196_RS01115	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IR196_RS01125	COG0583	DNA-binding transcription factor activity
IR196_RS01130	COG0154	amidase activity
IR196_RS01140	COG3153	acetyltransferase
IR196_RS01160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IR196_RS01185	COG0673	inositol 2-dehydrogenase activity
IR196_RS01200	COG3842	ATPase activity
IR196_RS01230	COG1309	transcriptional regulator
IR196_RS01245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR196_RS01250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR196_RS01255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IR196_RS01270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IR196_RS01280	COG4786	Flagellar basal body rod
IR196_RS01285	COG1157	protein secretion by the type III secretion system
IR196_RS01295	COG1815	bacterial-type flagellum-dependent cell motility
IR196_RS01300	COG1558	bacterial-type flagellum-dependent cell motility
IR196_RS01305	COG1677	Flagellar hook-basal body complex protein FliE
IR196_RS01310	COG4786	Flagellar basal body rod
IR196_RS01315	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IR196_RS01320	COG1706	bacterial-type flagellum-dependent cell motility
IR196_RS01340	COG1338	Plays a role in the flagellum-specific transport system
IR196_RS01345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IR196_RS01360	COG1360	Flagellar Motor Protein
IR196_RS01405	COG5443	negative regulation of bacterial-type flagellum assembly
IR196_RS01410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IR196_RS01420	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IR196_RS01455	COG0735	belongs to the Fur family
IR196_RS01460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR196_RS01480	COG0523	cobalamin synthesis protein
IR196_RS01485	COG1959	2 iron, 2 sulfur cluster binding
IR196_RS01490	COG2971	BadF BadG BcrA BcrD
IR196_RS01540	COG4264	IucA IucC family
IR196_RS01570	COG0765	amino acid transport
IR196_RS01575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS01585	COG0251	oxidation-reduction process
IR196_RS01590	COG0477	Major facilitator Superfamily
IR196_RS01615	COG2835	tetraacyldisaccharide 4'-kinase activity
IR196_RS01625	COG2169	Transcriptional regulator
IR196_RS01625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR196_RS01635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IR196_RS01640	COG1846	Transcriptional regulator
IR196_RS01645	COG1764	response to oxidative stress
IR196_RS01665	COG0066	3-isopropylmalate dehydratase activity
IR196_RS01690	COG0339	signal peptide processing
IR196_RS01695	COG2239	Acts as a magnesium transporter
IR196_RS01700	COG1217	gtp-binding protein TYPA
IR196_RS01710	COG1079	Belongs to the binding-protein-dependent transport system permease family
IR196_RS01720	COG3845	ABC transporter
IR196_RS01735	COG0402	S-adenosylhomocysteine deaminase activity
IR196_RS01745	COG3706	GGDEF domain
IR196_RS01750	COG1473	amidohydrolase
IR196_RS01760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS01770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS01785	COG4221	oxidoreductase activity
IR196_RS01795	COG3119	arylsulfatase activity
IR196_RS01805	COG0583	DNA-binding transcription factor activity
IR196_RS01820	COG2354	Protein conserved in bacteria
IR196_RS01825	COG0346	lactoylglutathione lyase activity
IR196_RS01835	COG0640	Transcriptional regulator
IR196_RS01850	COG1132	(ABC) transporter
IR196_RS01855	COG1802	Transcriptional regulator
IR196_RS01860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR196_RS01870	COG3842	ATPase activity
IR196_RS01875	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS01880	COG0395	ABC-type sugar transport system, permease component
IR196_RS01885	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS01900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR196_RS01910	COG4214	carbohydrate transport
IR196_RS01915	COG1129	ABC transporter
IR196_RS01925	COG1253	flavin adenine dinucleotide binding
IR196_RS01970	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS01975	COG0583	DNA-binding transcription factor activity
IR196_RS01980	COG0697	spore germination
IR196_RS01990	COG2814	Major facilitator Superfamily
IR196_RS02005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IR196_RS02010	COG3585	molybdate ion transport
IR196_RS02025	COG2197	response regulator
IR196_RS02040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR196_RS02045	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IR196_RS02065	COG0110	maltose O-acetyltransferase activity
IR196_RS02085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR196_RS02095	COG0463	Glycosyl transferase, family 2
IR196_RS02120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IR196_RS02125	COG4310	Domain of unknown function (DUF2172)
IR196_RS02130	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IR196_RS02145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IR196_RS02180	COG0252	asparaginase activity
IR196_RS02185	COG1113	amino acid transport
IR196_RS02190	COG2186	Transcriptional regulator
IR196_RS02200	COG2814	Major facilitator Superfamily
IR196_RS02210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR196_RS02215	COG1129	ABC transporter
IR196_RS02220	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS02225	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS02235	COG0673	inositol 2-dehydrogenase activity
IR196_RS02240	COG2115	Belongs to the xylose isomerase family
IR196_RS02245	COG1070	Carbohydrate kinase
IR196_RS02255	COG4213	ABC transporter substrate-binding protein
IR196_RS02260	COG1129	ABC transporter
IR196_RS02265	COG4214	carbohydrate transport
IR196_RS02305	COG0583	DNA-binding transcription factor activity
IR196_RS02375	COG1846	Transcriptional regulator
IR196_RS02415	COG4953	penicillin-binding protein 1C
IR196_RS02420	COG2373	Large extracellular alpha-helical protein
IR196_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS02430	COG0583	DNA-binding transcription factor activity
IR196_RS02460	COG1175	transmembrane transport
IR196_RS02465	COG0395	ABC-type sugar transport system, permease component
IR196_RS02470	COG3842	ATPase activity
IR196_RS02480	COG0673	inositol 2-dehydrogenase activity
IR196_RS02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS02495	COG1126	abc transporter atp-binding protein
IR196_RS02500	COG0765	amino acid transport
IR196_RS02505	COG0765	amino acid transport
IR196_RS02510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS02515	COG3608	succinylglutamate desuccinylase aspartoacylase
IR196_RS02520	COG0006	proline dipeptidase activity
IR196_RS02525	COG2423	ornithine cyclodeaminase activity
IR196_RS02530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR196_RS02535	COG1522	sequence-specific DNA binding
IR196_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS02545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR196_RS02550	COG3189	MarR family transcriptional regulator
IR196_RS02555	COG4774	siderophore transport
IR196_RS02565	COG1120	ATPase activity
IR196_RS02575	COG2204	response regulator
IR196_RS02580	COG4191	Histidine kinase
IR196_RS02585	COG1301	dicarboxylic acid transport
IR196_RS02590	COG1252	NADH dehydrogenase
IR196_RS02595	COG2985	domain, Protein
IR196_RS02620	COG1940	carbohydrate kinase activity
IR196_RS02625	COG3142	Participates in the control of copper homeostasis
IR196_RS02635	COG2814	Major facilitator Superfamily
IR196_RS02645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS02665	COG0765	amino acid transport
IR196_RS02670	COG0765	amino acid transport
IR196_RS02680	COG4187	Peptidase family M20/M25/M40
IR196_RS02690	COG0028	Belongs to the TPP enzyme family
IR196_RS02705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS02710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IR196_RS02715	COG4521	taurine ABC transporter
IR196_RS02720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS02725	COG2885	chlorophyll binding
IR196_RS02740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR196_RS02750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS02770	COG1473	amidohydrolase
IR196_RS02795	COG0521	Mo-molybdopterin cofactor biosynthetic process
IR196_RS02800	COG2308	Evidence 4 Homologs of previously reported genes of
IR196_RS02810	COG1305	Transglutaminase-like
IR196_RS02820	COG0747	negative chemotaxis
IR196_RS02835	COG2111	Na H antiporter
IR196_RS02835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IR196_RS02840	COG1006	Multisubunit Na H antiporter MnhC subunit
IR196_RS02845	COG0651	ATP synthesis coupled electron transport
IR196_RS02850	COG1863	multisubunit Na H antiporter MnhE subunit
IR196_RS02855	COG2212	antiporter activity
IR196_RS02870	COG4988	ABC transporter
IR196_RS02875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IR196_RS02880	COG1271	oxidase subunit
IR196_RS02885	COG1294	oxidase, subunit
IR196_RS02895	COG2188	Transcriptional regulator
IR196_RS02900	COG2971	BadF BadG BcrA BcrD
IR196_RS02910	COG1175	transmembrane transport
IR196_RS02915	COG0395	ABC-type sugar transport system, permease component
IR196_RS02920	COG0673	inositol 2-dehydrogenase activity
IR196_RS02935	COG0022	dehydrogenase e1 component
IR196_RS02965	COG0577	efflux transmembrane transporter activity
IR196_RS02965	COG1136	(ABC) transporter
IR196_RS02970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS02995	COG0477	Major facilitator Superfamily
IR196_RS03005	COG3254	rhamnose metabolic process
IR196_RS03015	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS03025	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS03030	COG1349	DNA-binding transcription factor activity
IR196_RS03035	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS03035	COG3347	Dehydrogenase
IR196_RS03040	COG4952	isomerase
IR196_RS03045	COG3145	DNA-N1-methyladenine dioxygenase activity
IR196_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS03060	COG3842	ATPase activity
IR196_RS03080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IR196_RS03125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS03135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS03150	COG0596	Alpha beta hydrolase
IR196_RS03155	COG4166	transmembrane transport
IR196_RS03175	COG0601	transmembrane transport
IR196_RS03180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS03185	COG4172	Belongs to the ABC transporter superfamily
IR196_RS03190	COG3706	GGDEF domain
IR196_RS03200	COG1064	alcohol dehydrogenase
IR196_RS03205	COG2207	Transcriptional regulator
IR196_RS03235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IR196_RS03260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IR196_RS03265	COG1959	2 iron, 2 sulfur cluster binding
IR196_RS03270	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IR196_RS03275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS03280	COG4558	Periplasmic binding protein
IR196_RS03285	COG3720	iron ion transport
IR196_RS03295	COG1629	transport
IR196_RS03295	COG4206	TonB-dependent receptor
IR196_RS03315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR196_RS03330	COG1079	Belongs to the binding-protein-dependent transport system permease family
IR196_RS03340	COG3845	ABC transporter
IR196_RS03350	COG1183	phosphatidylcholine synthase activity
IR196_RS03355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR196_RS03380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IR196_RS03385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IR196_RS03400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IR196_RS03405	COG0785	Cytochrome C biogenesis protein
IR196_RS03435	COG0330	HflC and HflK could
IR196_RS03445	COG2202	Pas domain
IR196_RS03445	COG3920	Histidine kinase
IR196_RS03455	COG3706	GGDEF domain
IR196_RS03465	COG0697	spore germination
IR196_RS03470	COG0187	DNA topoisomerase II activity
IR196_RS03485	COG0154	amidase activity
IR196_RS03495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR196_RS03500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IR196_RS03505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IR196_RS03510	COG1960	acyl-CoA dehydrogenase activity
IR196_RS03515	COG0540	Belongs to the ATCase OTCase family
IR196_RS03520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IR196_RS03525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IR196_RS03530	COG0758	DNA mediated transformation
IR196_RS03540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IR196_RS03545	COG0557	exoribonuclease II activity
IR196_RS03575	COG0784	Response regulator, receiver
IR196_RS03585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR196_RS03590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IR196_RS03630	COG1121	(ABC) transporter
IR196_RS03635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR196_RS03640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IR196_RS03645	COG3842	ATPase activity
IR196_RS03660	COG1177	transmembrane transport
IR196_RS03665	COG1609	Transcriptional regulator
IR196_RS03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS03700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS03720	COG1177	transmembrane transport
IR196_RS03725	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS03730	COG3842	ATPase activity
IR196_RS03740	COG0183	Belongs to the thiolase family
IR196_RS03745	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IR196_RS03755	COG1414	Transcriptional regulator
IR196_RS03770	COG0583	DNA-binding transcription factor activity
IR196_RS03775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IR196_RS03780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IR196_RS03785	COG3485	protocatechuate 3,4-dioxygenase
IR196_RS03790	COG3485	protocatechuate 3,4-dioxygenase
IR196_RS03800	COG0683	leucine binding
IR196_RS03820	COG3842	ATPase activity
IR196_RS03825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IR196_RS03840	COG0444	Belongs to the ABC transporter superfamily
IR196_RS03845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS03850	COG0601	transmembrane transport
IR196_RS03870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR196_RS03875	COG1126	abc transporter atp-binding protein
IR196_RS03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS03885	COG0765	amino acid transport
IR196_RS03890	COG0765	amino acid transport
IR196_RS03895	COG1609	Transcriptional regulator
IR196_RS03910	COG0395	ABC-type sugar transport system, permease component
IR196_RS03920	COG0471	metal ion transport
IR196_RS03920	COG3273	potassium ion transport
IR196_RS03925	COG3265	gluconokinase activity
IR196_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS03935	COG2186	Transcriptional regulator
IR196_RS03940	COG0277	FAD linked oxidase domain protein
IR196_RS03945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IR196_RS03950	COG2084	Dehydrogenase
IR196_RS03955	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS03965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IR196_RS03970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR196_RS03975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR196_RS03990	COG2252	PERMEase
IR196_RS04010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR196_RS04030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IR196_RS04035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IR196_RS04040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IR196_RS04045	COG2205	protein histidine kinase activity
IR196_RS04050	COG0745	RESPONSE REGULATOR receiver
IR196_RS04065	COG4608	Belongs to the ABC transporter superfamily
IR196_RS04070	COG0444	Belongs to the ABC transporter superfamily
IR196_RS04075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS04100	COG2011	ABC-type metal ion transport system permease component
IR196_RS04105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IR196_RS04110	COG1464	Belongs to the NlpA lipoprotein family
IR196_RS04125	COG4771	TonB-dependent receptor
IR196_RS04130	COG2819	hydrolase of the alpha beta superfamily
IR196_RS04135	COG4607	ABC-type enterochelin transport system periplasmic component
IR196_RS04140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS04145	COG4605	iron ion homeostasis
IR196_RS04150	COG4604	ABC transporter, ATP-binding protein
IR196_RS04160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS04170	COG0747	negative chemotaxis
IR196_RS04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS04195	COG0765	amino acid transport
IR196_RS04200	COG1126	abc transporter atp-binding protein
IR196_RS04205	COG0248	Ppx GppA phosphatase
IR196_RS04210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IR196_RS04215	COG0477	Major facilitator Superfamily
IR196_RS04220	COG3842	ATPase activity
IR196_RS04225	COG0395	ABC-type sugar transport system, permease component
IR196_RS04230	COG1175	transmembrane transport
IR196_RS04245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IR196_RS04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR196_RS04250	COG3453	Protein conserved in bacteria
IR196_RS04260	COG5001	Diguanylate cyclase
IR196_RS04260	COG3300	MHYT domain
IR196_RS04270	COG1840	ABC-type Fe3 transport system, periplasmic component
IR196_RS04275	COG3842	ATPase activity
IR196_RS04290	COG2132	Multicopper oxidase
IR196_RS04295	COG0477	Major facilitator Superfamily
IR196_RS04300	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IR196_RS04305	COG0450	alkyl hydroperoxide reductase
IR196_RS04320	COG0673	inositol 2-dehydrogenase activity
IR196_RS04330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS04335	COG3962	Belongs to the TPP enzyme family
IR196_RS04345	COG3718	enzyme involved in inositol metabolism
IR196_RS04350	COG2259	Doxx family
IR196_RS04355	COG0483	inositol monophosphate 1-phosphatase activity
IR196_RS04370	COG1840	ABC-type Fe3 transport system, periplasmic component
IR196_RS04380	COG1522	sequence-specific DNA binding
IR196_RS04390	COG1063	alcohol dehydrogenase
IR196_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS04400	COG3842	ATPase activity
IR196_RS04420	COG1609	Transcriptional regulator
IR196_RS04435	COG2822	iron ion transport
IR196_RS04460	COG0509	glycine decarboxylation via glycine cleavage system
IR196_RS04465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IR196_RS04475	COG2814	Major facilitator Superfamily
IR196_RS04500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS04515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR196_RS04545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IR196_RS04575	COG2113	Glycine betaine
IR196_RS04580	COG4176	ABC-type proline glycine betaine transport system permease component
IR196_RS04585	COG4175	Glycine betaine
IR196_RS04600	COG1737	Transcriptional regulator
IR196_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS04625	COG0395	ABC-type sugar transport system, permease component
IR196_RS04630	COG0251	oxidation-reduction process
IR196_RS04640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR196_RS04650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR196_RS04655	COG1063	alcohol dehydrogenase
IR196_RS04660	COG2721	sulfolactate sulfo-lyase activity
IR196_RS04670	COG0246	Mannitol dehydrogenase
IR196_RS04685	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS04690	COG1129	ABC transporter
IR196_RS04695	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS04705	COG3386	PFAM SMP-30 Gluconolaconase
IR196_RS04710	COG1120	ATPase activity
IR196_RS04715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS04750	COG1285	pathogenesis
IR196_RS04840	COG3772	lysozyme
IR196_RS04910	COG3561	AntA/AntB antirepressor
IR196_RS05075	COG3237	CsbD-like
IR196_RS05125	COG2205	protein histidine kinase activity
IR196_RS05135	COG1177	transmembrane transport
IR196_RS05140	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS05145	COG3842	ATPase activity
IR196_RS05160	COG2224	Isocitrate lyase
IR196_RS05170	COG3781	membrane
IR196_RS05185	COG0174	glutamine synthetase
IR196_RS05190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS05210	COG1230	cation diffusion facilitator family transporter
IR196_RS05250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IR196_RS05255	COG0625	glutathione transferase activity
IR196_RS05260	COG0583	DNA-binding transcription factor activity
IR196_RS05280	COG1418	mRNA catabolic process
IR196_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS05290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IR196_RS05295	COG0363	glucosamine-6-phosphate deaminase activity
IR196_RS05300	COG0129	dihydroxy-acid dehydratase activity
IR196_RS05305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IR196_RS05335	COG0444	Belongs to the ABC transporter superfamily
IR196_RS05340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS05350	COG0747	negative chemotaxis
IR196_RS05370	COG2197	response regulator
IR196_RS05395	COG3842	ATPase activity
IR196_RS05400	COG3842	ATPase activity
IR196_RS05410	COG0395	ABC-type sugar transport system, permease component
IR196_RS05425	COG1335	isochorismatase
IR196_RS05435	COG0583	DNA-binding transcription factor activity
IR196_RS05445	COG1346	cytolysis
IR196_RS05485	COG1129	ABC transporter
IR196_RS05495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR196_RS05505	COG2197	response regulator
IR196_RS05520	COG2267	carboxylic ester hydrolase activity
IR196_RS05535	COG2814	Major facilitator Superfamily
IR196_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS05560	COG1024	Enoyl-CoA hydratase
IR196_RS05565	COG1960	acyl-CoA dehydrogenase activity
IR196_RS05575	COG1024	Enoyl-CoA hydratase
IR196_RS05575	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR196_RS05585	COG1802	Transcriptional regulator
IR196_RS05595	COG0765	amino acid transport
IR196_RS05600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS05605	COG0436	Aminotransferase
IR196_RS05610	COG1846	Transcriptional regulator
IR196_RS05615	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IR196_RS05630	COG1024	Enoyl-CoA hydratase
IR196_RS05630	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR196_RS05635	COG0183	Belongs to the thiolase family
IR196_RS05640	COG1960	acyl-CoA dehydrogenase activity
IR196_RS05655	COG1431	PFAM Stem cell self-renewal protein Piwi
IR196_RS05665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IR196_RS05700	COG2814	Major facilitator Superfamily
IR196_RS05705	COG1238	metal cluster binding
IR196_RS05725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR196_RS05750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR196_RS05790	COG0789	Transcriptional regulator
IR196_RS05805	COG0730	response to heat
IR196_RS05820	COG1201	RNA secondary structure unwinding
IR196_RS05830	COG1793	dna ligase
IR196_RS05855	COG0789	Transcriptional regulator
IR196_RS05875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS05905	COG2390	Transcriptional regulator
IR196_RS05910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS05915	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS05935	COG1129	ABC transporter
IR196_RS05940	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS05945	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS05955	COG2376	Dihydroxyacetone kinase
IR196_RS05965	COG2376	Dihydroxyacetone kinase
IR196_RS05980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS05985	COG1126	abc transporter atp-binding protein
IR196_RS05990	COG0765	amino acid transport
IR196_RS06005	COG1522	sequence-specific DNA binding
IR196_RS06010	COG0583	DNA-binding transcription factor activity
IR196_RS06015	COG0028	Belongs to the TPP enzyme family
IR196_RS06020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS06025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS06030	COG4592	Periplasmic binding protein
IR196_RS06035	COG1120	ATPase activity
IR196_RS06045	COG4774	siderophore transport
IR196_RS06045	COG1629	transport
IR196_RS06055	COG1802	Transcriptional regulator
IR196_RS06060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IR196_RS06070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR196_RS06075	COG1063	alcohol dehydrogenase
IR196_RS06080	COG1312	Catalyzes the dehydration of D-mannonate
IR196_RS06085	COG0246	Mannitol dehydrogenase
IR196_RS06110	COG2358	TRAP transporter, solute receptor (TAXI family
IR196_RS06115	COG4944	Protein of unknown function (DUF1109)
IR196_RS06135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IR196_RS06155	COG3732	PTS system glucitol sorbitol-specific
IR196_RS06165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR196_RS06185	COG0022	dehydrogenase e1 component
IR196_RS06190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR196_RS06195	COG0673	inositol 2-dehydrogenase activity
IR196_RS06200	COG3775	system Galactitol-specific IIC component
IR196_RS06235	COG4566	intracellular signal transduction
IR196_RS06240	COG4191	Histidine kinase
IR196_RS06245	COG1446	asparaginase
IR196_RS06250	COG0747	negative chemotaxis
IR196_RS06265	COG0601	transmembrane transport
IR196_RS06270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS06275	COG4172	Belongs to the ABC transporter superfamily
IR196_RS06285	COG0640	Transcriptional regulator
IR196_RS06295	COG4774	siderophore transport
IR196_RS06305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IR196_RS06310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR196_RS06320	COG3135	benzoate transporter
IR196_RS06325	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IR196_RS06340	COG0730	response to heat
IR196_RS06345	COG2188	Transcriptional regulator
IR196_RS06375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IR196_RS06390	COG1177	transmembrane transport
IR196_RS06395	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS06400	COG3842	ATPase activity
IR196_RS06410	COG0174	glutamine synthetase
IR196_RS06420	COG0686	Belongs to the AlaDH PNT family
IR196_RS06425	COG1522	sequence-specific DNA binding
IR196_RS06440	COG0475	glutathione-regulated potassium exporter activity
IR196_RS06440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR196_RS06455	COG0251	oxidation-reduction process
IR196_RS06515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR196_RS06520	COG5001	Diguanylate cyclase
IR196_RS06530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IR196_RS06545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS06550	COG0601	transmembrane transport
IR196_RS06555	COG0747	negative chemotaxis
IR196_RS06560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IR196_RS06565	COG2971	BadF BadG BcrA BcrD
IR196_RS06570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IR196_RS06585	COG0006	proline dipeptidase activity
IR196_RS06590	COG0163	prenyltransferase activity
IR196_RS06595	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IR196_RS06605	COG0826	peptidase U32
IR196_RS06620	COG2204	response regulator
IR196_RS06625	COG4191	Histidine kinase
IR196_RS06630	COG0477	Major facilitator Superfamily
IR196_RS06635	COG2207	Transcriptional regulator
IR196_RS06640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR196_RS06650	COG0183	Belongs to the thiolase family
IR196_RS06655	COG1960	acyl-CoA dehydrogenase activity
IR196_RS06660	COG0242	peptide deformylase activity
IR196_RS06665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR196_RS06675	COG2376	Dihydroxyacetone kinase
IR196_RS06680	COG1082	Xylose isomerase domain protein TIM barrel
IR196_RS06700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR196_RS06705	COG1802	Transcriptional regulator
IR196_RS06710	COG0583	DNA-binding transcription factor activity
IR196_RS06715	COG2079	MmgE PrpD family protein
IR196_RS06725	COG4608	Belongs to the ABC transporter superfamily
IR196_RS06730	COG0444	Belongs to the ABC transporter superfamily
IR196_RS06735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS06740	COG0601	transmembrane transport
IR196_RS06745	COG0747	negative chemotaxis
IR196_RS06750	COG1473	amidohydrolase
IR196_RS06765	COG1446	asparaginase
IR196_RS06785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IR196_RS06790	COG1070	Carbohydrate kinase
IR196_RS06800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR196_RS06805	COG0667	Aldo Keto reductase
IR196_RS06815	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS06830	COG0583	DNA-binding transcription factor activity
IR196_RS06835	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IR196_RS06845	COG2186	Transcriptional regulator
IR196_RS06850	COG1850	ribulose-bisphosphate carboxylase activity
IR196_RS06860	COG0287	Prephenate dehydrogenase
IR196_RS06875	COG1129	ABC transporter
IR196_RS06880	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS06885	COG0673	inositol 2-dehydrogenase activity
IR196_RS06940	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IR196_RS06990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR196_RS06990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR196_RS06995	COG0753	catalase activity
IR196_RS07000	COG0583	DNA-binding transcription factor activity
IR196_RS07015	COG3191	aminopeptidase activity
IR196_RS07020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IR196_RS07030	COG1663	tetraacyldisaccharide 4'-kinase activity
IR196_RS07035	COG1519	Transferase
IR196_RS07055	COG0312	modulator of DNA gyrase
IR196_RS07060	COG0475	glutathione-regulated potassium exporter activity
IR196_RS07060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR196_RS07070	COG0612	Peptidase, M16
IR196_RS07075	COG0612	Peptidase, M16
IR196_RS07080	COG0742	ribosomal rna small subunit methyltransferase
IR196_RS07090	COG0590	tRNA wobble adenosine to inosine editing
IR196_RS07095	COG3038	cytochrome b561
IR196_RS07115	COG0196	riboflavin kinase activity
IR196_RS07135	COG0459	protein refolding
IR196_RS07160	COG2259	Doxx family
IR196_RS07170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IR196_RS07175	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IR196_RS07190	COG2818	Glycosylase
IR196_RS07195	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS07205	COG0247	lactate metabolic process
IR196_RS07210	COG0277	FAD linked oxidase domain protein
IR196_RS07215	COG0277	FAD linked oxidase domain protein
IR196_RS07220	COG0583	DNA-binding transcription factor activity
IR196_RS07230	COG2186	Transcriptional regulator
IR196_RS07265	COG1846	Transcriptional regulator
IR196_RS07280	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS07285	COG1570	exodeoxyribonuclease VII activity
IR196_RS07290	COG0583	DNA-binding transcription factor activity
IR196_RS07320	COG1921	L-seryl-tRNASec selenium transferase activity
IR196_RS07335	COG3964	amidohydrolase
IR196_RS07345	COG0601	transmembrane transport
IR196_RS07350	COG0747	negative chemotaxis
IR196_RS07380	COG1116	anion transmembrane transporter activity
IR196_RS07385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS07400	COG0583	DNA-binding transcription factor activity
IR196_RS07410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IR196_RS07415	COG2894	cell division
IR196_RS07420	COG0850	regulation of cytokinetic process
IR196_RS07435	COG1088	dTDP-glucose 4,6-dehydratase activity
IR196_RS07450	COG0546	phosphoglycolate phosphatase activity
IR196_RS07450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IR196_RS07455	COG2918	glutathione biosynthetic process
IR196_RS07455	COG0189	ligase activity
IR196_RS07460	COG0367	asparagine synthase
IR196_RS07475	COG0444	Belongs to the ABC transporter superfamily
IR196_RS07485	COG0747	negative chemotaxis
IR196_RS07490	COG1363	Peptidase, m42
IR196_RS07505	COG1780	Probably involved in ribonucleotide reductase function
IR196_RS07510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IR196_RS07515	COG0300	oxidoreductase activity
IR196_RS07535	COG1454	alcohol dehydrogenase
IR196_RS07545	COG0673	inositol 2-dehydrogenase activity
IR196_RS07555	COG3842	ATPase activity
IR196_RS07570	COG1653	transport
IR196_RS07575	COG1609	Transcriptional regulator
IR196_RS07585	COG1802	Transcriptional regulator
IR196_RS07605	COG5654	RES domain protein
IR196_RS07615	COG4178	(ABC) transporter
IR196_RS07620	COG0583	DNA-binding transcription factor activity
IR196_RS07625	COG0656	L-ascorbic acid biosynthetic process
IR196_RS07630	COG2814	Major facilitator Superfamily
IR196_RS07635	COG0842	Transport permease protein
IR196_RS07640	COG1131	(ABC) transporter
IR196_RS07650	COG1309	transcriptional regulator
IR196_RS07655	COG0824	Thioesterase
IR196_RS07655	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR196_RS07660	COG3246	L-lysine catabolic process to acetate
IR196_RS07680	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR196_RS07685	COG1070	Carbohydrate kinase
IR196_RS07690	COG1349	DNA-binding transcription factor activity
IR196_RS07695	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS07700	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS07705	COG1129	ABC transporter
IR196_RS07740	COG1349	DNA-binding transcription factor activity
IR196_RS07760	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IR196_RS07780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IR196_RS07785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR196_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR196_RS07805	COG2181	nitrate reductase activity
IR196_RS07810	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IR196_RS07815	COG1140	nitrate reductase beta subunit
IR196_RS07820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IR196_RS07825	COG2223	nitrite transmembrane transporter activity
IR196_RS07840	COG4589	Belongs to the CDS family
IR196_RS07855	COG2453	phosphatase
IR196_RS07855	COG0671	phosphoesterase, PA-phosphatase related
IR196_RS07860	COG2267	carboxylic ester hydrolase activity
IR196_RS07865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR196_RS07875	COG0583	DNA-binding transcription factor activity
IR196_RS07880	COG0657	acetylesterase activity
IR196_RS07910	COG0745	RESPONSE REGULATOR receiver
IR196_RS07940	COG3276	selenocysteine insertion sequence binding
IR196_RS07960	COG2864	formate dehydrogenase
IR196_RS07965	COG0437	4 iron, 4 sulfur cluster binding
IR196_RS07975	COG1305	Transglutaminase-like
IR196_RS07980	COG0709	Synthesizes selenophosphate from selenide and ATP
IR196_RS07985	COG2233	PERMEase
IR196_RS07990	COG0288	reversible hydration of carbon dioxide
IR196_RS08015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR196_RS08030	COG0765	amino acid transport
IR196_RS08035	COG0765	amino acid transport
IR196_RS08055	COG1309	transcriptional regulator
IR196_RS08060	COG0784	Response regulator, receiver
IR196_RS08060	COG2198	Histidine kinase
IR196_RS08060	COG2205	protein histidine kinase activity
IR196_RS08065	COG2197	response regulator
IR196_RS08075	COG1349	DNA-binding transcription factor activity
IR196_RS08080	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS08085	COG1129	ABC transporter
IR196_RS08090	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS08095	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS08115	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS08120	COG3040	lipid binding
IR196_RS08125	COG3842	ATPase activity
IR196_RS08130	COG1840	ABC-type Fe3 transport system, periplasmic component
IR196_RS08145	COG2207	Transcriptional regulator
IR196_RS08150	COG4774	siderophore transport
IR196_RS08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS08165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS08170	COG1120	ATPase activity
IR196_RS08175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IR196_RS08180	COG0156	8-amino-7-oxononanoate synthase activity
IR196_RS08185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IR196_RS08190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR196_RS08195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR196_RS08205	COG1069	ribulokinase activity
IR196_RS08215	COG4214	carbohydrate transport
IR196_RS08305	COG3453	Protein conserved in bacteria
IR196_RS08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR196_RS08320	COG1477	protein flavinylation
IR196_RS08335	COG3038	cytochrome b561
IR196_RS08355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IR196_RS08365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IR196_RS08375	COG1063	alcohol dehydrogenase
IR196_RS08410	COG5622	Protein required for attachment to host cells
IR196_RS08440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR196_RS08460	COG2235	arginine
IR196_RS08480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IR196_RS08515	COG0071	Belongs to the small heat shock protein (HSP20) family
IR196_RS08540	COG0798	PFAM Bile acid sodium symporter
IR196_RS08545	COG1393	Belongs to the ArsC family
IR196_RS08550	COG0431	NADPH-dependent FMN reductase
IR196_RS08560	COG1695	Transcriptional regulator
IR196_RS08585	COG2207	Transcriptional regulator
IR196_RS08620	COG3177	Filamentation induced by cAMP protein fic
IR196_RS08655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IR196_RS08670	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IR196_RS08675	COG3806	Anti-sigma factor
IR196_RS08680	COG1595	DNA-templated transcription, initiation
IR196_RS08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS08740	COG1126	abc transporter atp-binding protein
IR196_RS08745	COG0765	amino acid transport
IR196_RS08755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS08760	COG0165	Argininosuccinate lyase
IR196_RS08765	COG0583	DNA-binding transcription factor activity
IR196_RS08795	COG0446	pyridine nucleotide-disulphide oxidoreductase
IR196_RS08795	COG1902	pentaerythritol trinitrate reductase activity
IR196_RS08805	COG4215	(ABC) transporter
IR196_RS08810	COG4215	(ABC) transporter
IR196_RS08815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS08820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR196_RS08830	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS08850	COG2390	Transcriptional regulator
IR196_RS08855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR196_RS08860	COG1653	transport
IR196_RS08865	COG1175	transmembrane transport
IR196_RS08870	COG0395	ABC-type sugar transport system, permease component
IR196_RS08880	COG3842	ATPase activity
IR196_RS08905	COG0659	secondary active sulfate transmembrane transporter activity
IR196_RS08915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IR196_RS08950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IR196_RS08960	COG0583	DNA-binding transcription factor activity
IR196_RS08965	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS08970	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS08985	COG1473	amidohydrolase
IR196_RS09020	COG1473	amidohydrolase
IR196_RS09030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS09035	COG0601	transmembrane transport
IR196_RS09040	COG0747	negative chemotaxis
IR196_RS09075	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IR196_RS09105	COG0583	DNA-binding transcription factor activity
IR196_RS09120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IR196_RS09125	COG2233	PERMEase
IR196_RS09130	COG0523	cobalamin synthesis protein
IR196_RS09135	COG0163	prenyltransferase activity
IR196_RS09140	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IR196_RS09145	COG3618	amidohydrolase
IR196_RS09155	COG0583	DNA-binding transcription factor activity
IR196_RS09165	COG0477	Major facilitator Superfamily
IR196_RS09170	COG1280	lysine exporter protein (LysE YggA)
IR196_RS09175	COG0306	phosphate transporter
IR196_RS09180	COG1414	Transcriptional regulator
IR196_RS09195	COG0028	Belongs to the TPP enzyme family
IR196_RS09210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IR196_RS09255	COG2963	transposase activity
IR196_RS09260	COG2837	iron assimilation
IR196_RS09265	COG2390	Transcriptional regulator
IR196_RS09270	COG3347	Dehydrogenase
IR196_RS09270	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS09280	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS09285	COG1129	ABC transporter
IR196_RS09295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IR196_RS09300	COG3959	Transketolase, thiamine diphosphate binding domain
IR196_RS09305	COG3958	Transketolase
IR196_RS09310	COG1850	ribulose-bisphosphate carboxylase activity
IR196_RS09315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR196_RS09320	COG1126	abc transporter atp-binding protein
IR196_RS09325	COG0765	amino acid transport
IR196_RS09330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS09345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS09380	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS09400	COG1177	transmembrane transport
IR196_RS09405	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS09410	COG3842	ATPase activity
IR196_RS09425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS09445	COG1917	Cupin 2, conserved barrel domain protein
IR196_RS09460	COG1177	transmembrane transport
IR196_RS09465	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS09470	COG3842	ATPase activity
IR196_RS09475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IR196_RS09480	COG0583	DNA-binding transcription factor activity
IR196_RS09500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS09505	COG0601	transmembrane transport
IR196_RS09510	COG0747	negative chemotaxis
IR196_RS09520	COG0583	DNA-binding transcription factor activity
IR196_RS09535	COG4774	siderophore transport
IR196_RS09550	COG4608	Belongs to the ABC transporter superfamily
IR196_RS09565	COG0601	transmembrane transport
IR196_RS09570	COG0747	negative chemotaxis
IR196_RS09590	COG2723	6-phospho-beta-galactosidase activity
IR196_RS09595	COG0765	amino acid transport
IR196_RS09605	COG1609	Transcriptional regulator
IR196_RS09670	COG4172	Belongs to the ABC transporter superfamily
IR196_RS09675	COG4239	(ABC) transporter, permease
IR196_RS09680	COG4174	ABC transporter (Permease)
IR196_RS09690	COG4166	transmembrane transport
IR196_RS09695	COG3474	cytochrome
IR196_RS09700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IR196_RS09705	COG1605	Chorismate mutase
IR196_RS09705	COG0077	Prephenate dehydratase
IR196_RS09710	COG2816	NAD+ diphosphatase activity
IR196_RS09725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IR196_RS09730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IR196_RS09735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IR196_RS09745	COG0583	DNA-binding transcription factor activity
IR196_RS09750	COG2855	membrane
IR196_RS09760	COG0539	negative regulation of cytoplasmic translation
IR196_RS09770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IR196_RS09785	COG0625	glutathione transferase activity
IR196_RS09795	COG0697	spore germination
IR196_RS09800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR196_RS09805	COG1960	acyl-CoA dehydrogenase activity
IR196_RS09810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IR196_RS09825	COG1024	Enoyl-CoA hydratase
IR196_RS09860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IR196_RS09865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IR196_RS09870	COG1845	cytochrome c oxidase, subunit III
IR196_RS09875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IR196_RS09895	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS09930	COG0346	lactoylglutathione lyase activity
IR196_RS09940	COG0489	protein tyrosine kinase activity
IR196_RS09945	COG0033	Phosphoglucomutase
IR196_RS09980	COG1072	(Pantothenic acid kinase))
IR196_RS10010	COG1272	protein, Hemolysin III
IR196_RS10035	COG1846	Transcriptional regulator
IR196_RS10045	COG0024	Methionine aminopeptidase
IR196_RS10050	COG0137	argininosuccinate synthase activity
IR196_RS10070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IR196_RS10080	COG3339	Conserved Protein
IR196_RS10090	COG2154	pterin-4-alpha-carbinolamine dehydratase
IR196_RS10095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IR196_RS10100	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IR196_RS10110	COG4181	ATPase activity
IR196_RS10120	COG0670	Belongs to the BI1 family
IR196_RS10175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IR196_RS10185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR196_RS10190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IR196_RS10200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR196_RS10210	COG0129	dihydroxy-acid dehydratase activity
IR196_RS10230	COG2199	diguanylate cyclase activity
IR196_RS10255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IR196_RS10260	COG4208	sulfate ABC transporter
IR196_RS10265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IR196_RS10270	COG3459	Glycosyltransferase 36 associated
IR196_RS10275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IR196_RS10280	COG0384	phenazine biosynthesis protein PhzF
IR196_RS10285	COG2226	methyltransferase
IR196_RS10290	COG1280	lysine exporter protein (LysE YggA)
IR196_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS10305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IR196_RS10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR196_RS10335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR196_RS10335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IR196_RS10350	COG2124	cytochrome p450
IR196_RS10355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IR196_RS10365	COG2153	protein acetylation
IR196_RS10385	COG1643	Atp-dependent helicase
IR196_RS10400	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IR196_RS10410	COG1388	LysM domain
IR196_RS10410	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS10415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IR196_RS10425	COG0180	Tryptophanyl-tRNA synthetase
IR196_RS10430	COG0728	peptidoglycan biosynthetic process
IR196_RS10435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IR196_RS10440	COG0281	malic enzyme
IR196_RS10440	COG0280	phosphate acetyltransferase
IR196_RS10445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IR196_RS10460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR196_RS10465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IR196_RS10465	COG0116	Belongs to the methyltransferase superfamily
IR196_RS10480	COG0616	signal peptide processing
IR196_RS10490	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IR196_RS10495	COG1137	ATPase activity
IR196_RS10500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IR196_RS10505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IR196_RS10510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR196_RS10520	COG0071	Belongs to the small heat shock protein (HSP20) family
IR196_RS10540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS10550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IR196_RS10560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IR196_RS10570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IR196_RS10575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR196_RS10580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IR196_RS10585	COG0792	nuclease activity
IR196_RS10590	COG1648	precorrin-2 dehydrogenase activity
IR196_RS10590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IR196_RS10600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IR196_RS10605	COG0175	sulfate reduction
IR196_RS10640	COG2197	response regulator
IR196_RS10645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR196_RS10650	COG0175	sulfate reduction
IR196_RS10660	COG1218	3'(2'),5'-bisphosphate nucleotidase
IR196_RS10680	COG2197	response regulator
IR196_RS10700	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS10720	COG1368	sulfuric ester hydrolase activity
IR196_RS10725	COG5265	(ABC) transporter
IR196_RS10730	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS10735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS10740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IR196_RS10745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR196_RS10755	COG2022	thiamine diphosphate biosynthetic process
IR196_RS10770	COG0351	phosphomethylpyrimidine kinase
IR196_RS10775	COG5001	Diguanylate cyclase
IR196_RS10785	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
IR196_RS10790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS10795	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS10805	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS10815	COG4993	Dehydrogenase
IR196_RS10820	COG0789	Transcriptional regulator
IR196_RS10825	COG1174	glycine betaine transport
IR196_RS10830	COG1125	glycine betaine transport
IR196_RS10835	COG1174	glycine betaine transport
IR196_RS10840	COG1732	Glycine betaine
IR196_RS10845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IR196_RS10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
IR196_RS10860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IR196_RS10870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IR196_RS10880	COG3618	amidohydrolase
IR196_RS10885	COG1414	Transcriptional regulator
IR196_RS10895	COG1175	transmembrane transport
IR196_RS10900	COG0395	ABC-type sugar transport system, permease component
IR196_RS10905	COG3842	ATPase activity
IR196_RS10910	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS10915	COG3254	rhamnose metabolic process
IR196_RS10930	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS10940	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS10955	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IR196_RS10975	COG5328	Belongs to the UPF0262 family
IR196_RS11010	COG0829	nickel cation binding
IR196_RS11035	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IR196_RS11040	COG0830	nickel cation binding
IR196_RS11045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IR196_RS11050	COG0415	Belongs to the DNA photolyase family
IR196_RS11065	COG0438	transferase activity, transferring glycosyl groups
IR196_RS11085	COG4191	Histidine kinase
IR196_RS11090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS11095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR196_RS11100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IR196_RS11105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS11110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS11130	COG1309	transcriptional regulator
IR196_RS11135	COG0494	nUDIX hydrolase
IR196_RS11140	COG3842	ATPase activity
IR196_RS11145	COG0395	ABC-type sugar transport system, permease component
IR196_RS11160	COG0626	cystathionine gamma-synthase activity
IR196_RS11165	COG2186	Transcriptional regulator
IR196_RS11175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS11180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR196_RS11195	COG1175	transmembrane transport
IR196_RS11200	COG0395	ABC-type sugar transport system, permease component
IR196_RS11205	COG3842	ATPase activity
IR196_RS11215	COG0493	'glutamate synthase
IR196_RS11220	COG0697	spore germination
IR196_RS11230	COG0166	Belongs to the GPI family
IR196_RS11250	COG0318	PFAM AMP-dependent synthetase and ligase
IR196_RS11275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS11285	COG2326	polyphosphate kinase activity
IR196_RS11290	COG5002	protein histidine kinase activity
IR196_RS11300	COG0463	Glycosyl transferase, family 2
IR196_RS11325	COG3307	-O-antigen
IR196_RS11340	COG0438	transferase activity, transferring glycosyl groups
IR196_RS11350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IR196_RS11365	COG2967	ApaG domain
IR196_RS11375	COG0717	Belongs to the dCTP deaminase family
IR196_RS11395	COG0534	Mate efflux family protein
IR196_RS11400	COG0167	dihydroorotate dehydrogenase activity
IR196_RS11425	COG2205	protein histidine kinase activity
IR196_RS11425	COG0784	Response regulator, receiver
IR196_RS11430	COG1970	mechanosensitive ion channel activity
IR196_RS11435	COG0436	Aminotransferase
IR196_RS11440	COG0156	8-amino-7-oxononanoate synthase activity
IR196_RS11480	COG0583	DNA-binding transcription factor activity
IR196_RS11485	COG1380	Effector of murein hydrolase LrgA
IR196_RS11490	COG1346	cytolysis
IR196_RS11495	COG0346	lactoylglutathione lyase activity
IR196_RS11500	COG0346	lactoylglutathione lyase activity
IR196_RS11510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IR196_RS11525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IR196_RS11530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IR196_RS11545	COG1309	transcriptional regulator
IR196_RS11570	COG0019	diaminopimelate decarboxylase activity
IR196_RS11580	COG3938	Belongs to the proline racemase family
IR196_RS11610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IR196_RS11615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IR196_RS11625	COG3257	ureidoglycine aminohydrolase activity
IR196_RS11630	COG3648	Uricase
IR196_RS11630	COG3195	allantoin biosynthetic process
IR196_RS11635	COG2351	hydroxyisourate hydrolase activity
IR196_RS11640	COG2080	2 iron, 2 sulfur cluster binding
IR196_RS11645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IR196_RS11655	COG0583	DNA-binding transcription factor activity
IR196_RS11665	COG0402	S-adenosylhomocysteine deaminase activity
IR196_RS11670	COG1414	Transcriptional regulator
IR196_RS11675	COG3960	tartronate-semialdehyde synthase activity
IR196_RS11680	COG3622	Belongs to the hyi family
IR196_RS11685	COG2084	Dehydrogenase
IR196_RS11735	COG0642	Histidine kinase
IR196_RS11745	COG4232	protein-disulfide reductase activity
IR196_RS11750	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS11755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IR196_RS11755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR196_RS11765	COG2169	Transcriptional regulator
IR196_RS11765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IR196_RS11775	COG1393	Belongs to the ArsC family
IR196_RS11785	COG0740	serine-type endopeptidase activity
IR196_RS11805	COG0477	Major facilitator Superfamily
IR196_RS11810	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IR196_RS11825	COG1160	GTP binding
IR196_RS11865	COG3773	Cell wall hydrolase
IR196_RS11875	COG0356	it plays a direct role in the translocation of protons across the membrane
IR196_RS11885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IR196_RS11890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IR196_RS11900	COG1522	sequence-specific DNA binding
IR196_RS11910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IR196_RS11950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR196_RS11970	COG0142	geranyltranstransferase activity
IR196_RS11980	COG0752	glycyl-tRNA synthetase alpha subunit
IR196_RS11985	COG0751	glycine-tRNA ligase activity
IR196_RS11995	COG0009	L-threonylcarbamoyladenylate synthase
IR196_RS12015	COG1960	acyl-CoA dehydrogenase activity
IR196_RS12030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IR196_RS12035	COG0259	pyridoxamine-phosphate oxidase activity
IR196_RS12050	COG0484	heat shock protein binding
IR196_RS12055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR196_RS12075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IR196_RS12080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR196_RS12080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IR196_RS12085	COG0123	including yeast histone deacetylase and acetoin utilization protein
IR196_RS12090	COG1722	exodeoxyribonuclease VII activity
IR196_RS12100	COG2261	transglycosylase associated protein
IR196_RS12110	COG1741	Belongs to the pirin family
IR196_RS12115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IR196_RS12130	COG1794	racemase activity, acting on amino acids and derivatives
IR196_RS12155	COG5265	(ABC) transporter
IR196_RS12160	COG0688	phosphatidylethanolamine metabolic process
IR196_RS12165	COG1183	phosphatidylcholine synthase activity
IR196_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS12180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IR196_RS12195	COG0305	Participates in initiation and elongation during chromosome replication
IR196_RS12205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IR196_RS12210	COG0359	binds to the 23S rRNA
IR196_RS12220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IR196_RS12225	COG0360	Binds together with S18 to 16S ribosomal RNA
IR196_RS12230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IR196_RS12245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR196_RS12250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IR196_RS12255	COG1561	YicC-like family, N-terminal region
IR196_RS12260	COG0194	GDP metabolic process
IR196_RS12275	COG0312	modulator of DNA gyrase
IR196_RS12290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IR196_RS12295	COG0109	protoheme IX farnesyltransferase activity
IR196_RS12305	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IR196_RS12320	COG3346	SURF1 family
IR196_RS12325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IR196_RS12330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IR196_RS12335	COG0328	RNA-DNA hybrid ribonuclease activity
IR196_RS12340	COG0678	peroxiredoxin activity
IR196_RS12360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IR196_RS12365	COG0612	Peptidase, M16
IR196_RS12380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IR196_RS12390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR196_RS12400	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IR196_RS12440	COG1196	nuclear chromosome segregation
IR196_RS12455	COG0574	Belongs to the PEP-utilizing enzyme family
IR196_RS12455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IR196_RS12460	COG0726	polysaccharide deacetylase
IR196_RS12475	COG3258	Cytochrome c
IR196_RS12490	COG1268	BioY protein
IR196_RS12495	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IR196_RS12500	COG2351	hydroxyisourate hydrolase activity
IR196_RS12515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR196_RS12595	COG1216	Glycosyl transferase, family 2
IR196_RS12620	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IR196_RS12625	COG1088	dTDP-glucose 4,6-dehydratase activity
IR196_RS12630	COG1091	dTDP-4-dehydrorhamnose reductase activity
IR196_RS12635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR196_RS12645	COG1877	trehalose-phosphatase activity
IR196_RS12650	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IR196_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS12670	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IR196_RS12675	COG1309	transcriptional regulator
IR196_RS12680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR196_RS12700	COG2186	Transcriptional regulator
IR196_RS12705	COG2807	transmembrane transport
IR196_RS12710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IR196_RS12720	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS12730	COG0433	COG0433 Predicted ATPase
IR196_RS12745	COG2010	Cytochrome c
IR196_RS12760	COG0318	PFAM AMP-dependent synthetase and ligase
IR196_RS12775	COG4957	zinc ion binding
IR196_RS12785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IR196_RS12795	COG0154	amidase activity
IR196_RS12800	COG2166	iron-sulfur cluster assembly
IR196_RS12810	COG2205	protein histidine kinase activity
IR196_RS12840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IR196_RS12870	COG4235	cytochrome complex assembly
IR196_RS12875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IR196_RS12880	COG1138	Cytochrome C-type biogenesis protein
IR196_RS12885	COG3088	subunit of a heme lyase
IR196_RS12895	COG0745	RESPONSE REGULATOR receiver
IR196_RS12900	COG2205	protein histidine kinase activity
IR196_RS12905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IR196_RS12910	COG2205	protein histidine kinase activity
IR196_RS12910	COG2202	Pas domain
IR196_RS12915	COG0308	aminopeptidase N
IR196_RS12930	COG1573	uracil-dna glycosylase
IR196_RS12940	COG3021	interspecies interaction between organisms
IR196_RS12945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IR196_RS12955	COG0625	glutathione transferase activity
IR196_RS12990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IR196_RS13020	COG3743	rRNA binding
IR196_RS13020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR196_RS13025	COG0741	lytic transglycosylase activity
IR196_RS13035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IR196_RS13040	COG1573	uracil-dna glycosylase
IR196_RS13050	COG1758	RNA polymerase activity
IR196_RS13060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IR196_RS13065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IR196_RS13070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IR196_RS13075	COG2223	nitrite transmembrane transporter activity
IR196_RS13080	COG2207	Transcriptional regulator
IR196_RS13095	COG0681	Belongs to the peptidase S26 family
IR196_RS13120	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IR196_RS13130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IR196_RS13165	COG0494	nUDIX hydrolase
IR196_RS13180	COG0215	cysteine-tRNA ligase activity
IR196_RS13190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IR196_RS13200	COG0739	heme binding
IR196_RS13205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IR196_RS13210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IR196_RS13215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR196_RS13220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IR196_RS13235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR196_RS13255	COG0488	(ABC) transporter
IR196_RS13265	COG0105	UTP biosynthetic process
IR196_RS13270	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IR196_RS13275	COG0314	molybdopterin synthase activity
IR196_RS13280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IR196_RS13285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IR196_RS13330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IR196_RS13340	COG0243	molybdopterin cofactor binding
IR196_RS13350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IR196_RS13355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IR196_RS13360	COG0628	permease
IR196_RS13410	COG2252	PERMEase
IR196_RS13440	COG0628	permease
IR196_RS13445	COG0626	cystathionine gamma-synthase activity
IR196_RS13450	COG0671	phosphoesterase, PA-phosphatase related
IR196_RS13455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS13460	COG4597	amino acid ABC transporter
IR196_RS13465	COG0765	amino acid transport
IR196_RS13470	COG1126	abc transporter atp-binding protein
IR196_RS13485	COG0640	Transcriptional regulator
IR196_RS13495	COG1733	regulation of RNA biosynthetic process
IR196_RS13520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IR196_RS13530	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IR196_RS13535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IR196_RS13545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR196_RS13550	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IR196_RS13560	COG0113	porphobilinogen synthase activity
IR196_RS13585	COG2989	Protein conserved in bacteria
IR196_RS13590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IR196_RS13595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IR196_RS13600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR196_RS13600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IR196_RS13615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR196_RS13620	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IR196_RS13640	COG0416	fatty acid biosynthetic process
IR196_RS13645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IR196_RS13650	COG0776	regulation of translation
IR196_RS13665	COG0356	it plays a direct role in the translocation of protons across the membrane
IR196_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS13745	COG1396	sequence-specific DNA binding
IR196_RS13770	COG1742	UPF0060 membrane protein
IR196_RS13800	COG0438	transferase activity, transferring glycosyl groups
IR196_RS13825	COG1612	heme a metabolic process
IR196_RS13835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IR196_RS13840	COG0010	Belongs to the arginase family
IR196_RS13845	COG2329	Antibiotic biosynthesis monooxygenase
IR196_RS13850	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IR196_RS13855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IR196_RS13860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IR196_RS13870	COG1832	CoA-binding protein
IR196_RS13905	COG1940	carbohydrate kinase activity
IR196_RS13915	COG1175	transmembrane transport
IR196_RS13925	COG0165	Argininosuccinate lyase
IR196_RS13930	COG3842	ATPase activity
IR196_RS13935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS13955	COG0277	FAD linked oxidase domain protein
IR196_RS13960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IR196_RS13970	COG2814	Major facilitator Superfamily
IR196_RS13990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS14045	COG0829	nickel cation binding
IR196_RS14050	COG0831	urea catabolic process
IR196_RS14055	COG0832	Belongs to the urease beta subunit family
IR196_RS14065	COG4413	Urea transporter
IR196_RS14070	COG0830	nickel cation binding
IR196_RS14080	COG2610	gluconate transmembrane transporter activity
IR196_RS14085	COG1285	pathogenesis
IR196_RS14110	COG4574	serine-type endopeptidase inhibitor activity
IR196_RS14115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IR196_RS14120	COG2358	TRAP transporter, solute receptor (TAXI family
IR196_RS14135	COG1309	transcriptional regulator
IR196_RS14155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR196_RS14160	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR196_RS14165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR196_RS14175	COG0649	NAD binding
IR196_RS14180	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IR196_RS14185	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IR196_RS14195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IR196_RS14200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IR196_RS14210	COG0713	ATP synthesis coupled electron transport
IR196_RS14225	COG1007	ATP synthesis coupled electron transport
IR196_RS14240	COG0346	lactoylglutathione lyase activity
IR196_RS14250	COG0442	prolyl-tRNA aminoacylation
IR196_RS14270	COG2910	NAD(P)H-binding
IR196_RS14275	COG1733	regulation of RNA biosynthetic process
IR196_RS14295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IR196_RS14300	COG0037	tRNA processing
IR196_RS14305	COG0483	inositol monophosphate 1-phosphatase activity
IR196_RS14310	COG2814	Major facilitator Superfamily
IR196_RS14315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IR196_RS14325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR196_RS14330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS14355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IR196_RS14360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IR196_RS14380	COG2514	catechol 2,3-dioxygenase activity
IR196_RS14385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IR196_RS14405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR196_RS14410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR196_RS14415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IR196_RS14425	COG2017	converts alpha-aldose to the beta-anomer
IR196_RS14430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IR196_RS14435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IR196_RS14440	COG3454	Phosphonate metabolism
IR196_RS14445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR196_RS14450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IR196_RS14465	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IR196_RS14470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IR196_RS14475	COG1522	sequence-specific DNA binding
IR196_RS14480	COG1573	uracil-dna glycosylase
IR196_RS14505	COG0316	Belongs to the HesB IscA family
IR196_RS14510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IR196_RS14515	COG0018	arginyl-trna synthetase
IR196_RS14525	COG1472	Belongs to the glycosyl hydrolase 3 family
IR196_RS14530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IR196_RS14535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IR196_RS14540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR196_RS14545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IR196_RS14550	COG0805	protein transport
IR196_RS14560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IR196_RS14565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR196_RS14580	COG1862	Preprotein translocase
IR196_RS14600	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IR196_RS14625	COG0544	peptidyl-prolyl cis-trans isomerase activity
IR196_RS14630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IR196_RS14645	COG4765	Protein conserved in bacteria
IR196_RS14650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IR196_RS14655	COG0439	Biotin carboxylase
IR196_RS14660	COG0511	ligase activity, forming carbon-carbon bonds
IR196_RS14680	COG0436	Aminotransferase
IR196_RS14685	COG1530	ribonuclease E activity
IR196_RS14695	COG0860	N-Acetylmuramoyl-L-alanine amidase
IR196_RS14700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IR196_RS14710	COG1196	nuclear chromosome segregation
IR196_RS14710	COG0739	heme binding
IR196_RS14710	COG0741	lytic transglycosylase activity
IR196_RS14715	COG2833	Protein of unknown function (DUF455)
IR196_RS14720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IR196_RS14740	COG2945	thiolester hydrolase activity
IR196_RS14755	COG0719	Fe-S assembly protein
IR196_RS14760	COG0396	ATPase activity
IR196_RS14765	COG0719	Fe-S assembly protein
IR196_RS14770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IR196_RS14775	COG2151	metal-sulfur cluster biosynthetic enzyme
IR196_RS14800	COG0513	Belongs to the DEAD box helicase family
IR196_RS14810	COG0316	Belongs to the HesB IscA family
IR196_RS14825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IR196_RS14850	COG2084	Dehydrogenase
IR196_RS14855	COG0625	glutathione transferase activity
IR196_RS14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS14875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IR196_RS14910	COG1309	transcriptional regulator
IR196_RS14915	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS14925	COG2989	Protein conserved in bacteria
IR196_RS14965	COG0488	(ABC) transporter
IR196_RS15000	COG2948	multi-organism process
IR196_RS15020	COG3846	protein secretion by the type IV secretion system
IR196_RS15035	COG3451	type IV secretory pathway VirB4
IR196_RS15045	COG3838	Conjugal transfer protein Trbc
IR196_RS15050	COG4962	Type ii secretion system protein e
IR196_RS15065	COG0583	DNA-binding transcription factor activity
IR196_RS15075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IR196_RS15110	COG0741	lytic transglycosylase activity
IR196_RS15120	COG4959	Type IV secretory pathway protease TraF
IR196_RS15185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IR196_RS15190	COG1216	Glycosyl transferase, family 2
IR196_RS15190	COG0463	Glycosyl transferase, family 2
IR196_RS15200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS15210	COG5000	phosphorelay sensor kinase activity
IR196_RS15215	COG2204	response regulator
IR196_RS15220	COG0569	domain protein
IR196_RS15235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IR196_RS15245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IR196_RS15265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IR196_RS15270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IR196_RS15280	COG1393	Belongs to the ArsC family
IR196_RS15285	COG2188	Transcriptional regulator
IR196_RS15290	COG3624	Phosphonate C-P lyase system protein PhnG
IR196_RS15300	COG3626	phosphonate metabolism
IR196_RS15305	COG3627	carbon phosphorus lyase activity
IR196_RS15310	COG4107	phosphonate C-P lyase system protein PhnK
IR196_RS15315	COG4778	phosphonate C-P lyase system protein PhnL
IR196_RS15325	COG3454	Phosphonate metabolism
IR196_RS15335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IR196_RS15340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IR196_RS15345	COG3639	organic phosphonate transmembrane transporter activity
IR196_RS15350	COG3639	organic phosphonate transmembrane transporter activity
IR196_RS15355	COG2095	MarC family integral membrane protein
IR196_RS15360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IR196_RS15370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IR196_RS15385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IR196_RS15390	COG0343	queuine tRNA-ribosyltransferase activity
IR196_RS15400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS15405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IR196_RS15410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR196_RS15415	COG0583	DNA-binding transcription factor activity
IR196_RS15420	COG1960	acyl-CoA dehydrogenase activity
IR196_RS15425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IR196_RS15435	COG1752	Esterase of the alpha-beta hydrolase superfamily
IR196_RS15440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IR196_RS15445	COG0302	gtp cyclohydrolase
IR196_RS15455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IR196_RS15460	COG1686	Belongs to the peptidase S11 family
IR196_RS15480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IR196_RS15485	COG3956	TIGRFAM MazG family protein
IR196_RS15490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IR196_RS15500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR196_RS15510	COG0427	acetyl-CoA hydrolase
IR196_RS15530	COG2897	thiosulfate sulfurtransferase activity
IR196_RS15535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR196_RS15545	COG0513	Belongs to the DEAD box helicase family
IR196_RS15550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IR196_RS15560	COG0668	transmembrane transport
IR196_RS15565	COG0655	NAD(P)H dehydrogenase (quinone) activity
IR196_RS15570	COG1546	Belongs to the CinA family
IR196_RS15570	COG1058	Belongs to the CinA family
IR196_RS15580	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IR196_RS15590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IR196_RS15600	COG0668	transmembrane transport
IR196_RS15610	COG2072	flavoprotein involved in K transport
IR196_RS15620	COG2081	HI0933 family
IR196_RS15645	COG3106	COG3106 Predicted ATPase
IR196_RS15650	COG3768	UPF0283 membrane protein
IR196_RS15660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IR196_RS15670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IR196_RS15680	COG0492	ferredoxin-NADP+ reductase activity
IR196_RS15685	COG0633	Ferredoxin
IR196_RS15705	COG1127	ABC transporter
IR196_RS15710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IR196_RS15715	COG4948	Mandelate Racemase Muconate Lactonizing
IR196_RS15720	COG0438	transferase activity, transferring glycosyl groups
IR196_RS15730	COG0372	Belongs to the citrate synthase family
IR196_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS15745	COG0280	phosphate acetyltransferase
IR196_RS15745	COG0281	malic enzyme
IR196_RS15750	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IR196_RS15750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR196_RS15760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IR196_RS15765	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IR196_RS15785	COG0546	phosphoglycolate phosphatase activity
IR196_RS15795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IR196_RS15795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IR196_RS15800	COG0347	Belongs to the P(II) protein family
IR196_RS15805	COG0174	glutamine synthetase
IR196_RS15815	COG0546	phosphoglycolate phosphatase activity
IR196_RS15840	COG0084	hydrolase, TatD family'
IR196_RS15870	COG1597	lipid kinase activity
IR196_RS15885	COG2204	response regulator
IR196_RS15890	COG3852	Histidine kinase
IR196_RS15900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IR196_RS15900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IR196_RS15905	COG1546	Belongs to the CinA family
IR196_RS15905	COG1058	Belongs to the CinA family
IR196_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS15915	COG2867	negative regulation of translational initiation
IR196_RS15920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IR196_RS15930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IR196_RS15940	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR196_RS15945	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR196_RS15945	COG0022	dehydrogenase e1 component
IR196_RS15950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IR196_RS15955	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IR196_RS15960	COG5507	3-demethylubiquinone-9 3-methyltransferase
IR196_RS15965	COG0148	phosphopyruvate hydratase activity
IR196_RS15970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IR196_RS15975	COG0504	CTP synthase activity
IR196_RS15995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR196_RS16000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IR196_RS16005	COG0134	indole-3-glycerol-phosphate synthase activity
IR196_RS16010	COG0315	cyclic pyranopterin monophosphate synthase activity
IR196_RS16015	COG0303	'Molybdopterin
IR196_RS16020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IR196_RS16025	COG2333	competence protein COMEC
IR196_RS16025	COG0658	competence protein
IR196_RS16030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR196_RS16035	COG0372	Belongs to the citrate synthase family
IR196_RS16040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR196_RS16050	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IR196_RS16055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR196_RS16065	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR196_RS16085	COG0233	cytoplasmic translational termination
IR196_RS16090	COG0528	UMP kinase activity
IR196_RS16095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IR196_RS16100	COG0052	Belongs to the universal ribosomal protein uS2 family
IR196_RS16125	COG0537	adenosine 5'-monophosphoramidase activity
IR196_RS16150	COG1686	Belongs to the peptidase S11 family
IR196_RS16165	COG1760	l-serine dehydratase
IR196_RS16205	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IR196_RS16220	COG3800	Transcriptional regulator
IR196_RS16220	COG1396	sequence-specific DNA binding
IR196_RS16225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IR196_RS16230	COG4770	biotin carboxylase activity
IR196_RS16235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IR196_RS16235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IR196_RS16255	COG0656	L-ascorbic acid biosynthetic process
IR196_RS16260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IR196_RS16265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IR196_RS16270	COG0693	protein deglycase activity
IR196_RS16280	COG0538	isocitrate dehydrogenase activity
IR196_RS16305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IR196_RS16310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IR196_RS16315	COG2885	chlorophyll binding
IR196_RS16325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IR196_RS16330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR196_RS16335	COG0203	ribosomal protein L17
IR196_RS16340	COG0202	RNA polymerase activity
IR196_RS16350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IR196_RS16355	COG0563	adenylate kinase activity
IR196_RS16365	COG0200	Binds to the 23S rRNA
IR196_RS16375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IR196_RS16380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IR196_RS16385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IR196_RS16390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IR196_RS16395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IR196_RS16400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IR196_RS16405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IR196_RS16415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IR196_RS16425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IR196_RS16430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IR196_RS16440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IR196_RS16445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IR196_RS16450	COG0089	rRNA binding
IR196_RS16455	COG0088	Forms part of the polypeptide exit tunnel
IR196_RS16460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IR196_RS16470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR196_RS16475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IR196_RS16480	COG0049	tRNA binding
IR196_RS16485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IR196_RS16495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IR196_RS16500	COG0085	RNA polymerase activity
IR196_RS16505	COG0222	ribosome binding
IR196_RS16510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IR196_RS16515	COG0081	regulation of translation
IR196_RS16520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IR196_RS16530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IR196_RS16540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IR196_RS16555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IR196_RS16625	COG1278	Cold shock
IR196_RS16655	COG1494	fructose-1,6-bisphosphatase
IR196_RS16660	COG0488	(ABC) transporter
IR196_RS16670	COG0436	Aminotransferase
IR196_RS16700	COG1489	DNA binding
IR196_RS16705	COG0024	Methionine aminopeptidase
IR196_RS16710	COG2003	Belongs to the UPF0758 family
IR196_RS16725	COG0747	negative chemotaxis
IR196_RS16730	COG0601	transmembrane transport
IR196_RS16735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS16740	COG0444	Belongs to the ABC transporter superfamily
IR196_RS16745	COG4608	Belongs to the ABC transporter superfamily
IR196_RS16790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IR196_RS16800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IR196_RS16810	COG1797	cobyrinic acid a,c-diamide synthase activity
IR196_RS16820	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IR196_RS16835	COG1309	transcriptional regulator
IR196_RS16895	COG1492	cobalamin metabolic process
IR196_RS16910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IR196_RS16920	COG0583	DNA-binding transcription factor activity
IR196_RS16945	COG3264	Mechanosensitive ion channel
IR196_RS16945	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IR196_RS16960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IR196_RS16960	COG4651	solute:proton antiporter activity
IR196_RS16975	COG4208	sulfate ABC transporter
IR196_RS16980	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IR196_RS16995	COG1253	flavin adenine dinucleotide binding
IR196_RS17000	COG0586	Pfam SNARE associated Golgi protein
IR196_RS17015	COG4154	Belongs to the RbsD FucU family
IR196_RS17020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS17025	COG0601	transmembrane transport
IR196_RS17030	COG4608	Belongs to the ABC transporter superfamily
IR196_RS17080	COG1120	ATPase activity
IR196_RS17085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IR196_RS17095	COG4206	TonB-dependent receptor
IR196_RS17100	COG0842	Transport permease protein
IR196_RS17105	COG0842	Transport permease protein
IR196_RS17105	COG1129	ABC transporter
IR196_RS17110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS17115	COG1649	PFAM Uncharacterised BCR, COG1649
IR196_RS17130	COG0384	phenazine biosynthesis protein PhzF
IR196_RS17150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS17155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IR196_RS17165	COG3158	transport of potassium into the cell
IR196_RS17170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IR196_RS17180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR196_RS17195	COG0440	acetolactate synthase activity
IR196_RS17200	COG0028	Belongs to the TPP enzyme family
IR196_RS17210	COG3706	GGDEF domain
IR196_RS17215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IR196_RS17220	COG0560	Phosphoserine phosphatase
IR196_RS17230	COG2081	HI0933 family
IR196_RS17235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IR196_RS17245	COG0330	HflC and HflK could
IR196_RS17260	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IR196_RS17275	COG2814	Major facilitator Superfamily
IR196_RS17305	COG0277	FAD linked oxidase domain protein
IR196_RS17310	COG4702	Belongs to the UPF0303 family
IR196_RS17320	COG0210	DNA helicase
IR196_RS17340	COG1999	signal sequence binding
IR196_RS17350	COG0006	proline dipeptidase activity
IR196_RS17370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IR196_RS17380	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IR196_RS17390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IR196_RS17395	COG0849	cell division
IR196_RS17400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IR196_RS17405	COG1181	Belongs to the D-alanine--D-alanine ligase family
IR196_RS17410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IR196_RS17415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IR196_RS17420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IR196_RS17435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IR196_RS17460	COG0275	rRNA processing
IR196_RS17465	COG1914	H( )-stimulated, divalent metal cation uptake system
IR196_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS17485	COG3023	N-Acetylmuramoyl-L-alanine amidase
IR196_RS17490	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IR196_RS17510	COG4106	trans-aconitate 2-methyltransferase activity
IR196_RS17535	COG0640	Transcriptional regulator
IR196_RS17545	COG0477	Major facilitator Superfamily
IR196_RS17550	COG4106	trans-aconitate 2-methyltransferase activity
IR196_RS17560	COG2267	carboxylic ester hydrolase activity
IR196_RS17575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IR196_RS17585	COG4638	Rieske (2fe-2S)
IR196_RS17590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IR196_RS17595	COG2824	Alkylphosphonate utilization operon protein PhnA
IR196_RS17600	COG1335	isochorismatase
IR196_RS17650	COG3237	CsbD-like
IR196_RS17660	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IR196_RS17695	COG1475	DNA binding
IR196_RS17705	COG2801	Transposase and inactivated derivatives
IR196_RS17710	COG2842	Transposition protein
IR196_RS17740	COG4382	Mu-like prophage protein Gp16
IR196_RS17795	COG4373	Mu-like prophage FluMu protein gp28
IR196_RS17800	COG4383	Mu-like prophage protein gp29
IR196_RS17805	COG2369	cell adhesion
IR196_RS17945	COG2968	Membrane
IR196_RS17970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR196_RS17975	COG0358	DNA primase activity
IR196_RS17985	COG1610	YqeY-like protein
IR196_RS17990	COG0505	Belongs to the CarA family
IR196_RS18000	COG2321	neutral zinc metallopeptidase
IR196_RS18005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IR196_RS18015	COG1121	(ABC) transporter
IR196_RS18025	COG1278	Cold shock
IR196_RS18035	COG0702	epimerase
IR196_RS18040	COG1309	transcriptional regulator
IR196_RS18045	COG0436	Aminotransferase
IR196_RS18065	COG1175	transmembrane transport
IR196_RS18070	COG3833	ABC-type maltose transport systems, permease component
IR196_RS18075	COG1653	transport
IR196_RS18080	COG0583	DNA-binding transcription factor activity
IR196_RS18085	COG0492	ferredoxin-NADP+ reductase activity
IR196_RS18090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IR196_RS18095	COG1522	sequence-specific DNA binding
IR196_RS18105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IR196_RS18130	COG1607	acyl-coa hydrolase
IR196_RS18140	COG0556	nucleotide-excision repair
IR196_RS18160	COG1278	Cold shock
IR196_RS18170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR196_RS18180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IR196_RS18190	COG1846	Transcriptional regulator
IR196_RS18195	COG0745	RESPONSE REGULATOR receiver
IR196_RS18200	COG2205	protein histidine kinase activity
IR196_RS18205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IR196_RS18220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IR196_RS18230	COG1496	oxidoreductase activity
IR196_RS18235	COG0006	proline dipeptidase activity
IR196_RS18245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IR196_RS18260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IR196_RS18270	COG0012	GTP binding
IR196_RS18285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IR196_RS18290	COG2857	Cytochrome c1
IR196_RS18290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IR196_RS18305	COG1132	(ABC) transporter
IR196_RS18310	COG1132	(ABC) transporter
IR196_RS18315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IR196_RS18335	COG0408	coproporphyrinogen oxidase activity
IR196_RS18345	COG3811	Belongs to the UPF0386 family
IR196_RS18355	COG0617	tRNA 3'-terminal CCA addition
IR196_RS18370	COG0714	Associated with various cellular activities
IR196_RS18395	COG0435	Glutathione S-transferase
IR196_RS18400	COG3047	cAMP biosynthetic process
IR196_RS18405	COG1051	belongs to the nudix hydrolase family
IR196_RS18425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IR196_RS18435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IR196_RS18435	COG0512	Glutamine amidotransferase of anthranilate synthase
IR196_RS18445	COG1522	sequence-specific DNA binding
IR196_RS18485	COG4176	ABC-type proline glycine betaine transport system permease component
IR196_RS18490	COG4175	Glycine betaine
IR196_RS18495	COG4608	Belongs to the ABC transporter superfamily
IR196_RS18500	COG0444	Belongs to the ABC transporter superfamily
IR196_RS18505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS18510	COG0601	transmembrane transport
IR196_RS18515	COG0747	negative chemotaxis
IR196_RS18540	COG0482	sulfurtransferase activity
IR196_RS18570	COG2204	response regulator
IR196_RS18575	COG0745	RESPONSE REGULATOR receiver
IR196_RS18585	COG3180	Ammonia monooxygenase
IR196_RS18625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IR196_RS18635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IR196_RS18660	COG0010	Belongs to the arginase family
IR196_RS18670	COG1902	pentaerythritol trinitrate reductase activity
IR196_RS18675	COG0640	Transcriptional regulator
IR196_RS18680	COG2183	response to ionizing radiation
IR196_RS18685	COG3842	ATPase activity
IR196_RS18695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IR196_RS18700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS18710	COG5383	Protein conserved in bacteria
IR196_RS18715	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS18725	COG4821	SIS domain
IR196_RS18730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IR196_RS18740	COG2188	Transcriptional regulator
IR196_RS18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS18755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS18765	COG0243	molybdopterin cofactor binding
IR196_RS18780	COG1522	sequence-specific DNA binding
IR196_RS18790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS18800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IR196_RS18805	COG1595	DNA-templated transcription, initiation
IR196_RS18830	COG1228	amidohydrolase
IR196_RS18835	COG2986	histidine ammonia-lyase
IR196_RS18845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IR196_RS18850	COG3314	Sporulation integral membrane protein YlbJ
IR196_RS18865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IR196_RS18880	COG4214	carbohydrate transport
IR196_RS18890	COG4213	ABC transporter substrate-binding protein
IR196_RS18895	COG0800	Aldolase
IR196_RS18900	COG3734	2-keto-3-deoxy-galactonokinase
IR196_RS18905	COG0129	dihydroxy-acid dehydratase activity
IR196_RS18920	COG1879	ABC-type sugar transport system periplasmic component
IR196_RS18925	COG1129	ABC transporter
IR196_RS18930	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS18935	COG1172	Belongs to the binding-protein-dependent transport system permease family
IR196_RS18940	COG2186	Transcriptional regulator
IR196_RS18950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IR196_RS18960	COG0028	Belongs to the TPP enzyme family
IR196_RS18970	COG2271	Major facilitator Superfamily
IR196_RS18975	COG1737	Transcriptional regulator
IR196_RS18980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IR196_RS18995	COG0583	DNA-binding transcription factor activity
IR196_RS19015	COG0559	Belongs to the binding-protein-dependent transport system permease family
IR196_RS19030	COG1464	Belongs to the NlpA lipoprotein family
IR196_RS19040	COG2011	ABC-type metal ion transport system permease component
IR196_RS19055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IR196_RS19070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IR196_RS19115	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS19120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IR196_RS19125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IR196_RS19130	COG1609	Transcriptional regulator
IR196_RS19135	COG1846	Transcriptional regulator
IR196_RS19145	COG0523	cobalamin synthesis protein
IR196_RS19160	COG3738	Protein conserved in bacteria
IR196_RS19165	COG0400	carboxylic ester hydrolase activity
IR196_RS19170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IR196_RS19175	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IR196_RS19185	COG0251	oxidation-reduction process
IR196_RS19195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IR196_RS19200	COG0594	ribonuclease P activity
IR196_RS19210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IR196_RS19220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IR196_RS19230	COG3739	integral membrane protein
IR196_RS19240	COG2171	N-acyltransferase activity
IR196_RS19260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IR196_RS19275	COG0604	alcohol dehydrogenase
IR196_RS19280	COG0101	tRNA pseudouridine synthase activity
IR196_RS19285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IR196_RS19290	COG0242	peptide deformylase activity
IR196_RS19305	COG2827	Endonuclease containing a URI domain
IR196_RS19310	COG0481	GTPase activity
IR196_RS19320	COG1968	undecaprenyl-diphosphatase activity
IR196_RS19330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IR196_RS19345	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IR196_RS19350	COG1803	Methylglyoxal synthase
IR196_RS19360	COG1132	(ABC) transporter
IR196_RS19370	COG0588	phosphoglycerate mutase activity
IR196_RS19380	COG0778	Nitroreductase
IR196_RS19405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IR196_RS19415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IR196_RS19425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IR196_RS19430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IR196_RS19435	COG2226	methyltransferase
IR196_RS19440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IR196_RS19450	COG2900	Belongs to the SlyX family
IR196_RS19485	COG2199	diguanylate cyclase activity
IR196_RS19490	COG0579	oxidoreductase
IR196_RS19495	COG2176	DNA-directed DNA polymerase activity
IR196_RS19500	COG0154	amidase activity
IR196_RS19505	COG4608	Belongs to the ABC transporter superfamily
IR196_RS19515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IR196_RS19525	COG0747	negative chemotaxis
IR196_RS19535	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS19540	COG1802	Transcriptional regulator
IR196_RS19545	COG0583	DNA-binding transcription factor activity
IR196_RS19555	COG0590	tRNA wobble adenosine to inosine editing
IR196_RS19560	COG2807	transmembrane transport
IR196_RS19565	COG2814	Major facilitator Superfamily
IR196_RS19580	COG0667	Aldo Keto reductase
IR196_RS19585	COG0583	DNA-binding transcription factor activity
IR196_RS19620	COG1074	ATP-dependent DNA helicase activity
IR196_RS19635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IR196_RS19710	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS19735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IR196_RS19740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IR196_RS19750	COG0477	Major facilitator Superfamily
IR196_RS19770	COG1522	sequence-specific DNA binding
IR196_RS19795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS19800	COG4591	ABC-type transport system involved in lipoprotein release permease component
IR196_RS19800	COG1136	(ABC) transporter
IR196_RS19805	COG3698	Phosphodiester glycosidase
IR196_RS19820	COG0848	biopolymer transport protein
IR196_RS19850	COG3920	Histidine kinase
IR196_RS19865	COG0784	Response regulator, receiver
IR196_RS19910	COG0564	pseudouridine synthase activity
IR196_RS19915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR196_RS19925	COG4977	sequence-specific DNA binding
IR196_RS19930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IR196_RS19940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IR196_RS19950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IR196_RS19960	COG0385	Bile acid
IR196_RS19975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IR196_RS19980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IR196_RS19985	COG0037	tRNA processing
IR196_RS19995	COG2885	chlorophyll binding
IR196_RS20005	COG0823	Involved in the tonB-independent uptake of proteins
IR196_RS20015	COG0848	biopolymer transport protein
IR196_RS20025	COG0824	Thioesterase
IR196_RS20030	COG2255	four-way junction helicase activity
IR196_RS20035	COG0632	four-way junction helicase activity
IR196_RS20040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IR196_RS20070	COG0483	inositol monophosphate 1-phosphatase activity
IR196_RS20085	COG1132	(ABC) transporter
IR196_RS20095	COG0217	transcriptional regulatory protein
IR196_RS20105	COG1268	BioY protein
IR196_RS20115	COG1253	flavin adenine dinucleotide binding
IR196_RS20120	COG1692	metallophosphoesterase
IR196_RS20170	COG2133	pyrroloquinoline quinone binding
IR196_RS20175	COG3588	fructose-bisphosphate aldolase
IR196_RS20180	COG3304	Inner membrane component domain
IR196_RS20265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IR196_RS20270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IR196_RS20275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IR196_RS20280	COG0457	Tetratricopeptide repeat
IR196_RS20285	COG0469	pyruvate kinase activity
IR196_RS20300	COG3750	Belongs to the UPF0335 family
IR196_RS20305	COG0667	Aldo Keto reductase
IR196_RS20310	COG0488	(ABC) transporter
IR196_RS20325	COG4143	(ABC) transporter
IR196_RS20345	COG2258	MOSC domain
IR196_RS20350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IR196_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS20360	COG0583	DNA-binding transcription factor activity
IR196_RS20365	COG1329	Transcriptional regulator
IR196_RS20370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IR196_RS20385	COG0183	Belongs to the thiolase family
IR196_RS20395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IR196_RS20405	COG0142	geranyltranstransferase activity
IR196_RS20415	COG2814	Major facilitator Superfamily
IR196_RS20420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IR196_RS20425	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS20430	COG0738	Major facilitator superfamily
IR196_RS20440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IR196_RS20480	COG3938	Belongs to the proline racemase family
IR196_RS20485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IR196_RS20505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IR196_RS20515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IR196_RS20525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IR196_RS20545	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IR196_RS20570	COG0495	leucyl-tRNA aminoacylation
IR196_RS20575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IR196_RS20580	COG5425	PFAM Usg family protein
IR196_RS20585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IR196_RS20595	COG0501	Belongs to the peptidase M48B family
IR196_RS20600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IR196_RS20600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IR196_RS20610	COG0138	bifunctional purine biosynthesis protein purh
IR196_RS20615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IR196_RS20620	COG2270	Major facilitator Superfamily
IR196_RS20635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IR196_RS20640	COG1704	LemA family
IR196_RS20650	COG0228	four-way junction DNA binding
IR196_RS20655	COG1605	Chorismate mutase
IR196_RS20655	COG0287	Prephenate dehydrogenase
IR196_RS20660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IR196_RS20665	COG1620	l-lactate permease
IR196_RS20680	COG0288	reversible hydration of carbon dioxide
IR196_RS20690	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IR196_RS20700	COG2130	NADP-dependent
IR196_RS20730	COG0494	nUDIX hydrolase
IR196_RS20740	COG0793	Belongs to the peptidase S41A family
IR196_RS20755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IR196_RS20760	COG0799	negative regulation of ribosome biogenesis
IR196_RS20770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IR196_RS20775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IR196_RS20780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IR196_RS20795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IR196_RS20800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IR196_RS20815	COG2957	Belongs to the agmatine deiminase family
IR196_RS20825	COG0500	methyltransferase
IR196_RS20835	COG0534	Mate efflux family protein
IR196_RS20880	COG0739	heme binding
IR196_RS20885	COG1376	ErfK ybiS ycfS ynhG family protein
IR196_RS20900	COG2890	protein-(glutamine-N5) methyltransferase activity
IR196_RS20905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IR196_RS20915	COG0527	aspartate kinase activity
IR196_RS20920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IR196_RS20945	COG1040	competence protein
IR196_RS20960	COG0494	nUDIX hydrolase
IR196_RS20975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IR196_RS20980	COG0653	protein targeting
IR196_RS21005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR196_RS21010	COG0789	Transcriptional regulator
IR196_RS21020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IR196_RS21025	COG2217	Heavy metal translocating P-type atpase
IR196_RS21030	COG0640	Transcriptional regulator
IR196_RS21045	COG2132	Multicopper oxidase
IR196_RS21070	COG0789	Transcriptional regulator
IR196_RS21075	COG2814	Major facilitator Superfamily
IR196_RS21080	COG1937	Protein conserved in bacteria
IR196_RS21085	COG0678	peroxiredoxin activity
IR196_RS21085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IR196_RS21105	COG1937	Protein conserved in bacteria
IR196_RS21140	COG0740	serine-type endopeptidase activity
IR196_RS21150	COG0640	Transcriptional regulator
IR196_RS21165	COG0640	Transcriptional regulator
IR196_RS21170	COG1230	cation diffusion facilitator family transporter
IR196_RS21225	COG1396	sequence-specific DNA binding
IR196_RS21230	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IR196_RS21270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IR196_RS21315	COG0589	response to stress
IR196_RS21325	COG1250	3-hydroxyacyl-CoA dehydrogenase
IR196_RS21330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IR196_RS21335	COG2086	electron transfer activity
IR196_RS21340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IR196_RS21345	COG0720	synthase
IR196_RS21350	COG0602	queuosine metabolic process
IR196_RS21365	COG0300	oxidoreductase activity
IR196_RS21375	COG0697	spore germination
IR196_RS21380	COG1671	Belongs to the UPF0178 family
IR196_RS21385	COG1280	lysine exporter protein (LysE YggA)
IR196_RS21390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IR196_RS21395	COG0165	Argininosuccinate lyase
IR196_RS21420	COG2226	methyltransferase
IR196_RS21430	COG0287	Prephenate dehydrogenase
IR196_RS21450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IR196_RS21470	COG2884	Cell division ATP-binding protein ftsE
IR196_RS21515	COG0181	hydroxymethylbilane synthase activity
IR196_RS21520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IR196_RS21545	COG0697	spore germination
IR196_RS21550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IR196_RS21555	COG2233	PERMEase
IR196_RS21565	COG0745	RESPONSE REGULATOR receiver
IR196_RS21575	COG0488	(ABC) transporter
IR196_RS21585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IR196_RS21595	COG0004	ammonium transporteR
IR196_RS21600	COG1946	Acyl-CoA thioesterase
IR196_RS21605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IR196_RS21610	COG1764	response to oxidative stress
IR196_RS21650	COG3706	GGDEF domain
IR196_RS21655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IR196_RS21660	COG0335	large ribosomal subunit rRNA binding
IR196_RS21675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IR196_RS21710	COG1280	lysine exporter protein (LysE YggA)
IR196_RS21720	COG0508	dehydrogenase complex catalyzes the overall conversion of
IR196_RS21725	COG0567	Dehydrogenase, E1 component
IR196_RS21730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IR196_RS21735	COG0045	succinate-CoA ligase (ADP-forming) activity
IR196_RS21740	COG0039	L-malate dehydrogenase activity
IR196_RS21745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IR196_RS21755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IR196_RS21760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR196_RS21765	COG0552	protein localization to endoplasmic reticulum
IR196_RS21770	COG2917	probably involved in intracellular septation
IR196_RS21775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IR196_RS21790	COG0789	Transcriptional regulator
IR196_RS21800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IR196_RS21805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IR196_RS21810	COG4221	oxidoreductase activity
IR196_RS21835	COG4536	flavin adenine dinucleotide binding
IR196_RS21840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IR196_RS21860	COG0825	malonyl-CoA metabolic process
IR196_RS21875	COG0523	cobalamin synthesis protein
IR196_RS21880	COG1686	Belongs to the peptidase S11 family
IR196_RS21885	COG1473	amidohydrolase
IR196_RS21895	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS21910	COG1028	Short-chain dehydrogenase reductase Sdr
IR196_RS21920	COG1012	belongs to the aldehyde dehydrogenase family
IR196_RS21925	COG1024	Enoyl-CoA hydratase
IR196_RS21940	COG1609	Transcriptional regulator
IR196_RS21950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IR196_RS21970	COG4120	Belongs to the binding-protein-dependent transport system permease family
IR196_RS22000	COG0357	Ribosomal RNA small subunit methyltransferase G
IR196_RS22005	COG0445	tRNA wobble uridine modification
IR196_RS22010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IR196_RS22015	COG1331	Highly conserved protein containing a thioredoxin domain
IR196_RS22020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IR196_RS22025	COG1981	membrane
IR196_RS22030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IR196_RS22035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IR196_RS22050	COG0237	dephospho-CoA kinase activity
IR196_RS22055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IR196_RS22060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IR196_RS22095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IR196_RS22105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IR196_RS22110	COG0131	Imidazoleglycerol-phosphate dehydratase
IR196_RS22125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IR196_RS22130	COG0107	imidazoleglycerol-phosphate synthase activity
IR196_RS22135	COG0140	phosphoribosyl-ATP diphosphatase activity
IR196_RS22140	COG1072	(Pantothenic acid kinase))
IR196_RS22155	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IR196_RS22160	COG0745	RESPONSE REGULATOR receiver
IR196_RS22165	COG2205	protein histidine kinase activity
IR196_RS22170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IR196_RS22175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR196_RS22175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IR196_RS22180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IR196_RS22185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IR196_RS22190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IR196_RS22195	COG2205	protein histidine kinase activity
IR196_RS22200	COG3178	'Phosphotransferase
IR196_RS22205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IR196_RS22210	COG2887	Belongs to the helicase family. UvrD subfamily
IR196_RS22215	COG1074	ATP-dependent DNA helicase activity
IR196_RS22225	COG0285	dihydrofolate synthase activity
IR196_RS22230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IR196_RS22235	COG0159	tryptophan synthase activity
IR196_RS22245	COG0133	tryptophan synthase activity
IR196_RS22270	COG3135	benzoate transporter
IR196_RS22275	COG0596	Alpha beta hydrolase
IR196_RS22275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IR196_RS22280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IR196_RS22290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IR196_RS22295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IR196_RS22305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IR196_RS22315	COG1309	transcriptional regulator
IR196_RS22320	COG2814	Major facilitator Superfamily
IR196_RS22325	COG0667	Aldo Keto reductase
IR196_RS22350	COG0484	heat shock protein binding
IR196_RS22355	COG3963	phosphatidate phosphatase activity
IR196_RS22385	COG0606	chelatase, subunit chli
IR196_RS22410	COG1214	PFAM Peptidase M22, glycoprotease
IR196_RS22410	COG0456	acetyltransferase
IR196_RS22415	COG0189	ligase activity
IR196_RS22420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IR196_RS22425	COG2832	Protein of unknown function (DUF454)
IR196_RS22430	COG0436	Aminotransferase
IR196_RS22440	COG0573	inorganic phosphate transmembrane transporter activity
IR196_RS22450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IR196_RS22455	COG0704	Plays a role in the regulation of phosphate uptake
IR196_RS22460	COG0745	RESPONSE REGULATOR receiver
IR196_RS22465	COG3773	Cell wall hydrolase
IR196_RS22475	COG2309	aminopeptidase activity
IR196_RS22480	COG0783	Belongs to the Dps family
IR196_RS22485	COG1214	PFAM Peptidase M22, glycoprotease
IR196_RS22500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IR196_RS22510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IR196_RS22525	COG1396	sequence-specific DNA binding
IR196_RS22530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IR196_RS22535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IR196_RS22540	COG0779	Required for maturation of 30S ribosomal subunits
IR196_RS22555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IR196_RS22555	COG3064	Membrane
IR196_RS22560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IR196_RS22565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IR196_RS22570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IR196_RS22575	COG1185	polyribonucleotide nucleotidyltransferase activity
IR196_RS22580	COG2813	Specifically methylates the guanine in position
IR196_RS22585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IR196_RS22595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IR196_RS22610	COG0456	acetyltransferase
IR196_RS22630	COG0791	NLP P60 protein
IR196_RS22640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IR196_RS22675	COG4964	Belongs to the GSP D family
IR196_RS22715	COG1024	Enoyl-CoA hydratase
IR196_RS22720	COG0268	Binds directly to 16S ribosomal RNA
IR196_RS22730	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS22735	COG1177	transmembrane transport
IR196_RS22740	COG3842	ATPase activity
IR196_RS22780	COG3609	addiction module antidote protein, CC2985 family
IR196_RS22815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IR196_RS22840	COG1176	ABC-type spermidine putrescine transport system, permease component I
IR196_RS22845	COG1177	transmembrane transport
IR196_RS22850	COG3842	ATPase activity