locus-tag	class	description
CW732_RS00010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CW732_RS00025	COG0321	lipoyl(octanoyl) transferase activity
CW732_RS00030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CW732_RS00045	COG4682	membrane
CW732_RS00065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CW732_RS00070	COG1388	LysM domain
CW732_RS00070	COG0791	NLP P60 protein
CW732_RS00075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CW732_RS00085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CW732_RS00115	COG3340	Belongs to the peptidase S51 family
CW732_RS00130	COG2153	protein acetylation
CW732_RS00135	COG1876	peptidase activity
CW732_RS00145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CW732_RS00155	COG0427	acetyl-CoA hydrolase
CW732_RS00170	COG2226	methyltransferase
CW732_RS00175	COG2363	Small membrane protein
CW732_RS00180	COG1477	protein flavinylation
CW732_RS00200	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW732_RS00205	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW732_RS00210	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW732_RS00215	COG1805	sodium ion transport
CW732_RS00220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CW732_RS00230	COG2967	ApaG domain
CW732_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS00250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CW732_RS00260	COG0358	DNA primase activity
CW732_RS00265	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CW732_RS00270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CW732_RS00275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CW732_RS00285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CW732_RS00305	COG0800	Aldolase
CW732_RS00320	COG2271	Major facilitator Superfamily
CW732_RS00340	COG0702	epimerase
CW732_RS00345	COG4771	TonB-dependent receptor
CW732_RS00365	COG1914	H( )-stimulated, divalent metal cation uptake system
CW732_RS00405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW732_RS00435	COG1428	Deoxynucleoside kinase
CW732_RS00450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW732_RS00455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CW732_RS00460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CW732_RS00480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CW732_RS00490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CW732_RS00500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CW732_RS00505	COG0596	Alpha beta hydrolase
CW732_RS00515	COG0544	peptidyl-prolyl cis-trans isomerase activity
CW732_RS00525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CW732_RS00545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CW732_RS00550	COG3279	Response regulator of the LytR AlgR family
CW732_RS00555	COG2972	Histidine kinase
CW732_RS00585	COG0668	transmembrane transport
CW732_RS00595	COG1214	PFAM Peptidase M22, glycoprotease
CW732_RS00605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW732_RS00610	COG0577	efflux transmembrane transporter activity
CW732_RS00610	COG1136	(ABC) transporter
CW732_RS00615	COG0577	efflux transmembrane transporter activity
CW732_RS00615	COG1136	(ABC) transporter
CW732_RS00620	COG1136	(ABC) transporter
CW732_RS00630	COG2322	membrane
CW732_RS00635	COG1999	signal sequence binding
CW732_RS00655	COG1845	cytochrome c oxidase, subunit III
CW732_RS00660	COG0109	protoheme IX farnesyltransferase activity
CW732_RS00760	COG0509	glycine decarboxylation via glycine cleavage system
CW732_RS00770	COG0632	four-way junction helicase activity
CW732_RS00780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CW732_RS00785	COG2124	cytochrome p450
CW732_RS00790	COG2255	four-way junction helicase activity
CW732_RS00795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CW732_RS00825	COG0437	4 iron, 4 sulfur cluster binding
CW732_RS00840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CW732_RS00845	COG0195	Participates in both transcription termination and antitermination
CW732_RS00845	COG2251	uridine kinase activity
CW732_RS00850	COG0779	Required for maturation of 30S ribosomal subunits
CW732_RS00875	COG3118	belongs to the thioredoxin family
CW732_RS00880	COG1408	metallophosphoesterase
CW732_RS00905	COG2197	response regulator
CW732_RS00925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW732_RS00925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CW732_RS00960	COG2852	Protein conserved in bacteria
CW732_RS00965	COG1032	radical SAM domain protein
CW732_RS00975	COG1082	Xylose isomerase domain protein TIM barrel
CW732_RS00980	COG0366	Alpha amylase catalytic
CW732_RS00985	COG1501	Belongs to the glycosyl hydrolase 31 family
CW732_RS00990	COG0366	Alpha amylase catalytic
CW732_RS00995	COG1554	hydrolase, family 65, central catalytic
CW732_RS01000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW732_RS01005	COG2190	(PTS) system
CW732_RS01005	COG2211	Major facilitator Superfamily
CW732_RS01015	COG4206	TonB-dependent receptor
CW732_RS01015	COG1629	transport
CW732_RS01020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CW732_RS01030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW732_RS01050	COG2234	aminopeptidase activity
CW732_RS01070	COG2824	Alkylphosphonate utilization operon protein PhnA
CW732_RS01075	COG1482	cell wall glycoprotein biosynthetic process
CW732_RS01085	COG0745	RESPONSE REGULATOR receiver
CW732_RS01145	COG0531	amino acid
CW732_RS01150	COG5000	phosphorelay sensor kinase activity
CW732_RS01155	COG2198	Histidine kinase
CW732_RS01155	COG0643	Histidine kinase
CW732_RS01155	COG0784	Response regulator, receiver
CW732_RS01165	COG2340	Cysteine-rich secretory protein family
CW732_RS01170	COG3279	Response regulator of the LytR AlgR family
CW732_RS01180	COG4251	negative regulation of phosphorylation
CW732_RS01190	COG4251	negative regulation of phosphorylation
CW732_RS01200	COG0784	Response regulator, receiver
CW732_RS01210	COG2315	Protein conserved in bacteria
CW732_RS01225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW732_RS01230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CW732_RS01285	COG2197	response regulator
CW732_RS01330	COG0740	serine-type endopeptidase activity
CW732_RS01335	COG3118	belongs to the thioredoxin family
CW732_RS01355	COG0228	four-way junction DNA binding
CW732_RS01360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CW732_RS01365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CW732_RS01385	COG0633	Ferredoxin
CW732_RS01390	COG0492	ferredoxin-NADP+ reductase activity
CW732_RS01400	COG0489	protein tyrosine kinase activity
CW732_RS01420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CW732_RS01425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CW732_RS01430	COG5002	protein histidine kinase activity
CW732_RS01435	COG0745	RESPONSE REGULATOR receiver
CW732_RS01450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CW732_RS01465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW732_RS01470	COG0463	Glycosyl transferase, family 2
CW732_RS01485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CW732_RS01500	COG1522	sequence-specific DNA binding
CW732_RS01550	COG0792	nuclease activity
CW732_RS01555	COG1619	proteins homologs of microcin C7 resistance protein MccF
CW732_RS01560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW732_RS01560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW732_RS01570	COG2885	chlorophyll binding
CW732_RS01590	COG0123	including yeast histone deacetylase and acetoin utilization protein
CW732_RS01595	COG4977	sequence-specific DNA binding
CW732_RS01645	COG4771	TonB-dependent receptor
CW732_RS01660	COG1629	transport
CW732_RS01665	COG0166	Belongs to the GPI family
CW732_RS01675	COG3483	tryptophan 2,3-dioxygenase activity
CW732_RS01685	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CW732_RS01690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CW732_RS01695	COG1752	Esterase of the alpha-beta hydrolase superfamily
CW732_RS01700	COG0322	excinuclease ABC activity
CW732_RS01705	COG0189	ligase activity
CW732_RS01705	COG4067	protein conserved in archaea
CW732_RS01710	COG0189	ligase activity
CW732_RS01720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CW732_RS01725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CW732_RS01740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CW732_RS01750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CW732_RS01765	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CW732_RS01770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CW732_RS01775	COG0297	glycogen (starch) synthase activity
CW732_RS01785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CW732_RS01820	COG2268	Band 7 protein
CW732_RS01825	COG3655	Transcriptional regulator
CW732_RS01870	COG1381	Involved in DNA repair and RecF pathway recombination
CW732_RS01880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW732_RS01890	COG0626	cystathionine gamma-synthase activity
CW732_RS01915	COG0697	spore germination
CW732_RS01925	COG1561	YicC-like family, N-terminal region
CW732_RS01930	COG0194	GDP metabolic process
CW732_RS01935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CW732_RS01995	COG1733	regulation of RNA biosynthetic process
CW732_RS02000	COG1652	LysM domain
CW732_RS02010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CW732_RS02040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CW732_RS02070	COG1309	transcriptional regulator
CW732_RS02075	COG1538	Outer membrane efflux protein
CW732_RS02085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW732_RS02095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CW732_RS02110	COG0288	reversible hydration of carbon dioxide
CW732_RS02115	COG0659	secondary active sulfate transmembrane transporter activity
CW732_RS02135	COG0659	secondary active sulfate transmembrane transporter activity
CW732_RS02170	COG2304	oxidoreductase activity
CW732_RS02185	COG0714	Associated with various cellular activities
CW732_RS02190	COG4989	oxidoreductase activity
CW732_RS02195	COG4221	oxidoreductase activity
CW732_RS02215	COG3047	cAMP biosynthetic process
CW732_RS02215	COG2885	chlorophyll binding
CW732_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS02230	COG4953	penicillin-binding protein 1C
CW732_RS02235	COG2954	triphosphatase activity
CW732_RS02240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW732_RS02250	COG0469	pyruvate kinase activity
CW732_RS02260	COG0571	ribonuclease III activity
CW732_RS02265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW732_RS02270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW732_RS02275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CW732_RS02280	COG3341	Caulimovirus viroplasmin
CW732_RS02280	COG0328	RNA-DNA hybrid ribonuclease activity
CW732_RS02310	COG0352	thiamine-phosphate diphosphorylase activity
CW732_RS02310	COG0351	phosphomethylpyrimidine kinase
CW732_RS02325	COG1074	ATP-dependent DNA helicase activity
CW732_RS02340	COG0210	DNA helicase
CW732_RS02370	COG0720	synthase
CW732_RS02375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW732_RS02390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CW732_RS02390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CW732_RS02420	COG1573	uracil-dna glycosylase
CW732_RS02430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CW732_RS02445	COG1435	thymidine kinase activity
CW732_RS02455	COG1970	mechanosensitive ion channel activity
CW732_RS02460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CW732_RS02475	COG1505	serine-type exopeptidase activity
CW732_RS02500	COG1538	Outer membrane efflux protein
CW732_RS02525	COG1690	Belongs to the RtcB family
CW732_RS02535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW732_RS02570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CW732_RS02575	COG2827	Endonuclease containing a URI domain
CW732_RS02580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CW732_RS02585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW732_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS02595	COG3424	synthase
CW732_RS02605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW732_RS02615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CW732_RS02650	COG0439	Biotin carboxylase
CW732_RS02655	COG0511	ligase activity, forming carbon-carbon bonds
CW732_RS02660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW732_RS02665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CW732_RS02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CW732_RS02695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CW732_RS02700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CW732_RS02705	COG0066	3-isopropylmalate dehydratase activity
CW732_RS02715	COG0004	ammonium transporteR
CW732_RS02730	COG0069	glutamate synthase activity
CW732_RS02730	COG0070	glutamate synthase
CW732_RS02730	COG0067	glutamate synthase
CW732_RS02740	COG0165	Argininosuccinate lyase
CW732_RS02750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CW732_RS02755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CW732_RS02760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW732_RS02770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CW732_RS02775	COG0137	argininosuccinate synthase activity
CW732_RS02785	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS02790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CW732_RS02795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CW732_RS02805	COG0028	Belongs to the TPP enzyme family
CW732_RS02810	COG0129	dihydroxy-acid dehydratase activity
CW732_RS02825	COG0346	lactoylglutathione lyase activity
CW732_RS02830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CW732_RS02845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CW732_RS02880	COG0481	GTPase activity
CW732_RS02890	COG3275	phosphorelay sensor kinase activity
CW732_RS02900	COG3263	regulation of cellular component size
CW732_RS02910	COG0659	secondary active sulfate transmembrane transporter activity
CW732_RS02915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW732_RS02935	COG0594	ribonuclease P activity
CW732_RS02940	COG0793	Belongs to the peptidase S41A family
CW732_RS02950	COG2153	protein acetylation
CW732_RS02960	COG0698	ribose 5-phosphate isomerase
CW732_RS02965	COG0557	exoribonuclease II activity
CW732_RS02970	COG0393	Putative heavy-metal-binding
CW732_RS03005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW732_RS03035	COG0330	HflC and HflK could
CW732_RS03045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CW732_RS03055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CW732_RS03060	COG0445	tRNA wobble uridine modification
CW732_RS03105	COG0470	DNA polymerase III
CW732_RS03115	COG0126	phosphoglycerate kinase activity
CW732_RS03120	COG1388	LysM domain
CW732_RS03120	COG1705	Flagellar rod assembly protein muramidase FlgJ
CW732_RS03130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW732_RS03160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CW732_RS03195	COG0529	Catalyzes the synthesis of activated sulfate
CW732_RS03200	COG0175	sulfate reduction
CW732_RS03275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CW732_RS03290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CW732_RS03295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW732_RS03305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CW732_RS03320	COG1215	transferase activity, transferring glycosyl groups
CW732_RS03330	COG0151	Belongs to the GarS family
CW732_RS03345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CW732_RS03355	COG0859	PFAM glycosyl transferase family 9
CW732_RS03360	COG0633	Ferredoxin
CW732_RS03405	COG0356	it plays a direct role in the translocation of protons across the membrane
CW732_RS03410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW732_RS03415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CW732_RS03420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CW732_RS03425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CW732_RS03430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CW732_RS03450	COG0756	dUTP diphosphatase activity
CW732_RS03460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CW732_RS03475	COG0739	heme binding
CW732_RS03480	COG1607	acyl-coa hydrolase
CW732_RS03490	COG0758	DNA mediated transformation
CW732_RS03490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW732_RS03520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CW732_RS03530	COG1774	PSP1 C-terminal conserved region
CW732_RS03540	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CW732_RS03545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CW732_RS03560	COG4172	Belongs to the ABC transporter superfamily
CW732_RS03570	COG3227	Zinc metalloprotease (Elastase)
CW732_RS03600	COG1253	flavin adenine dinucleotide binding
CW732_RS03615	COG0113	porphobilinogen synthase activity
CW732_RS03620	COG0556	nucleotide-excision repair
CW732_RS03625	COG3012	SEC-C Motif Domain Protein
CW732_RS03635	COG0408	coproporphyrinogen oxidase activity
CW732_RS03650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CW732_RS03665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CW732_RS03680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CW732_RS03690	COG1981	membrane
CW732_RS03695	COG5000	phosphorelay sensor kinase activity
CW732_RS03700	COG1024	Enoyl-CoA hydratase
CW732_RS03710	COG2207	Transcriptional regulator
CW732_RS03710	COG1917	Cupin 2, conserved barrel domain protein
CW732_RS03725	COG1418	mRNA catabolic process
CW732_RS03745	COG0484	heat shock protein binding
CW732_RS03750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CW732_RS03755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CW732_RS03760	COG1121	(ABC) transporter
CW732_RS03765	COG0803	Belongs to the bacterial solute-binding protein 9 family
CW732_RS03775	COG4771	TonB-dependent receptor
CW732_RS03800	COG1999	signal sequence binding
CW732_RS03805	COG0750	zinc metalloprotease
CW732_RS03815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW732_RS03835	COG3590	peptidase
CW732_RS03865	COG0516	GMP reductase activity
CW732_RS03865	COG0517	IMP dehydrogenase activity
CW732_RS03890	COG0629	single-stranded DNA binding
CW732_RS03895	COG1404	Belongs to the peptidase S8 family
CW732_RS03925	COG4251	negative regulation of phosphorylation
CW732_RS03930	COG0784	Response regulator, receiver
CW732_RS03965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CW732_RS03985	COG2151	metal-sulfur cluster biosynthetic enzyme
CW732_RS03990	COG2166	iron-sulfur cluster assembly
CW732_RS04000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CW732_RS04010	COG0719	Fe-S assembly protein
CW732_RS04015	COG0396	ATPase activity
CW732_RS04025	COG0719	Fe-S assembly protein
CW732_RS04030	COG0316	Belongs to the HesB IscA family
CW732_RS04035	COG1858	cytochrome C peroxidase
CW732_RS04055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CW732_RS04100	COG0527	aspartate kinase activity
CW732_RS04220	COG3547	Transposase (IS116 IS110 IS902 family)
CW732_RS04265	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS04295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CW732_RS04365	COG3196	Protein conserved in bacteria
CW732_RS04450	COG0427	acetyl-CoA hydrolase
CW732_RS04465	COG0006	proline dipeptidase activity
CW732_RS04485	COG1053	succinate dehydrogenase
CW732_RS04490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CW732_RS04500	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CW732_RS04525	COG3275	phosphorelay sensor kinase activity
CW732_RS04530	COG3279	Response regulator of the LytR AlgR family
CW732_RS04540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW732_RS04570	COG0423	glycine-tRNA ligase activity
CW732_RS04605	COG0708	Exodeoxyribonuclease III
CW732_RS04610	COG1360	Flagellar Motor Protein
CW732_RS04615	COG0667	Aldo Keto reductase
CW732_RS04635	COG1530	ribonuclease E activity
CW732_RS04640	COG0776	regulation of translation
CW732_RS04670	COG5002	protein histidine kinase activity
CW732_RS04760	COG2217	Heavy metal translocating P-type atpase
CW732_RS04770	COG0612	Peptidase, M16
CW732_RS04775	COG0612	Peptidase, M16
CW732_RS04785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CW732_RS04790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CW732_RS04805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CW732_RS04815	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CW732_RS04840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW732_RS04855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW732_RS04870	COG3852	Histidine kinase
CW732_RS04875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CW732_RS04885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CW732_RS04890	COG0519	Catalyzes the synthesis of GMP from XMP
CW732_RS04905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CW732_RS04910	COG1968	undecaprenyl-diphosphatase activity
CW732_RS04920	COG2177	Part of the ABC transporter FtsEX involved in
CW732_RS04925	COG0495	leucyl-tRNA aminoacylation
CW732_RS04945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CW732_RS04955	COG5002	protein histidine kinase activity
CW732_RS04955	COG2198	Histidine kinase
CW732_RS04955	COG0784	Response regulator, receiver
CW732_RS04975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CW732_RS04985	COG0460	homoserine dehydrogenase
CW732_RS04985	COG0527	aspartate kinase activity
CW732_RS05005	COG0346	lactoylglutathione lyase activity
CW732_RS05015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW732_RS05025	COG2239	Acts as a magnesium transporter
CW732_RS05030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW732_RS05050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CW732_RS05060	COG0196	riboflavin kinase activity
CW732_RS05075	COG0193	aminoacyl-tRNA hydrolase activity
CW732_RS05080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CW732_RS05085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CW732_RS05100	COG1482	cell wall glycoprotein biosynthetic process
CW732_RS05115	COG0793	Belongs to the peptidase S41A family
CW732_RS05120	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CW732_RS05130	COG2095	MarC family integral membrane protein
CW732_RS05140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW732_RS05145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CW732_RS05145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CW732_RS05165	COG1360	Flagellar Motor Protein
CW732_RS05200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CW732_RS05205	COG1404	Belongs to the peptidase S8 family
CW732_RS05215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CW732_RS05245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CW732_RS05250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW732_RS05280	COG1959	2 iron, 2 sulfur cluster binding
CW732_RS05285	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CW732_RS05330	COG4263	nitrous-oxide reductase activity
CW732_RS05335	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW732_RS05360	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW732_RS05400	COG0084	hydrolase, TatD family'
CW732_RS05405	COG0252	asparaginase activity
CW732_RS05415	COG0811	peptide transport
CW732_RS05445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CW732_RS05450	COG0017	Asparaginyl-tRNA synthetase
CW732_RS05470	COG0233	cytoplasmic translational termination
CW732_RS05475	COG0528	UMP kinase activity
CW732_RS05480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CW732_RS05485	COG0052	Belongs to the universal ribosomal protein uS2 family
CW732_RS05490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CW732_RS05495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CW732_RS05505	COG1215	transferase activity, transferring glycosyl groups
CW732_RS05525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW732_RS05555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CW732_RS05580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CW732_RS05585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CW732_RS05610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CW732_RS05625	COG1054	Belongs to the UPF0176 family
CW732_RS05645	COG1629	transport
CW732_RS05645	COG4206	TonB-dependent receptor
CW732_RS05675	COG3608	succinylglutamate desuccinylase aspartoacylase
CW732_RS05675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CW732_RS05700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CW732_RS05710	COG0590	tRNA wobble adenosine to inosine editing
CW732_RS05720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CW732_RS05745	COG1253	flavin adenine dinucleotide binding
CW732_RS05785	COG2333	competence protein COMEC
CW732_RS05785	COG0658	competence protein
CW732_RS05790	COG0791	NLP P60 protein
CW732_RS05795	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW732_RS05805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CW732_RS05810	COG0793	Belongs to the peptidase S41A family
CW732_RS05815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CW732_RS05820	COG0300	oxidoreductase activity
CW732_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS05885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CW732_RS05890	COG2267	carboxylic ester hydrolase activity
CW732_RS05895	COG2001	Belongs to the MraZ family
CW732_RS05900	COG0275	rRNA processing
CW732_RS05915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CW732_RS05920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CW732_RS05925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CW732_RS05930	COG0772	Belongs to the SEDS family
CW732_RS05935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CW732_RS05940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW732_RS05955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CW732_RS05960	COG1610	YqeY-like protein
CW732_RS05980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CW732_RS05990	COG2239	Acts as a magnesium transporter
CW732_RS05995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CW732_RS06005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CW732_RS06025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CW732_RS06060	COG0463	Glycosyl transferase, family 2
CW732_RS06065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CW732_RS06070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CW732_RS06080	COG1185	polyribonucleotide nucleotidyltransferase activity
CW732_RS06085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CW732_RS06095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CW732_RS06125	COG2226	methyltransferase
CW732_RS06130	COG0569	domain protein
CW732_RS06145	COG0436	Aminotransferase
CW732_RS06150	COG3239	Fatty acid desaturase
CW732_RS06155	COG0357	Ribosomal RNA small subunit methyltransferase G
CW732_RS06160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CW732_RS06180	COG0527	aspartate kinase activity
CW732_RS06180	COG0460	homoserine dehydrogenase
CW732_RS06195	COG1410	methionine synthase
CW732_RS06195	COG0646	methionine synthase
CW732_RS06200	COG2329	Antibiotic biosynthesis monooxygenase
CW732_RS06215	COG1959	2 iron, 2 sulfur cluster binding
CW732_RS06220	COG0175	sulfate reduction
CW732_RS06225	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW732_RS06235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW732_RS06235	COG1648	precorrin-2 dehydrogenase activity
CW732_RS06240	COG0492	ferredoxin-NADP+ reductase activity
CW732_RS06245	COG1045	serine acetyltransferase
CW732_RS06270	COG1605	Chorismate mutase
CW732_RS06270	COG0077	Prephenate dehydratase
CW732_RS06280	COG0287	Prephenate dehydrogenase
CW732_RS06285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CW732_RS06290	COG1162	GTPase activity
CW732_RS06295	COG1490	D-aminoacyl-tRNA deacylase activity
CW732_RS06315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CW732_RS06320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CW732_RS06325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CW732_RS06375	COG0010	Belongs to the arginase family
CW732_RS06380	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CW732_RS06430	COG0584	glycerophosphoryl diester phosphodiesterase
CW732_RS06435	COG2081	HI0933 family
CW732_RS06445	COG1309	transcriptional regulator
CW732_RS06470	COG1187	pseudouridine synthase activity
CW732_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS06495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CW732_RS06510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CW732_RS06515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CW732_RS06525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CW732_RS06535	COG0022	dehydrogenase e1 component
CW732_RS06535	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW732_RS06550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CW732_RS06565	COG1428	Deoxynucleoside kinase
CW732_RS06585	COG0772	Belongs to the SEDS family
CW732_RS06590	COG0768	penicillin binding
CW732_RS06605	COG1077	Cell shape determining protein MreB Mrl
CW732_RS06610	COG0138	bifunctional purine biosynthesis protein purh
CW732_RS06630	COG0459	protein refolding
CW732_RS06635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CW732_RS06660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW732_RS06665	COG1754	DNA topoisomerase type I activity
CW732_RS06665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CW732_RS06675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW732_RS06695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CW732_RS06695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CW732_RS06705	COG0488	(ABC) transporter
CW732_RS06740	COG4716	Myosin-crossreactive antigen
CW732_RS06765	COG3174	membrane
CW732_RS06775	COG4716	Myosin-crossreactive antigen
CW732_RS06805	COG0783	Belongs to the Dps family
CW732_RS06820	COG1024	Enoyl-CoA hydratase
CW732_RS06820	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW732_RS06825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CW732_RS06830	COG0708	Exodeoxyribonuclease III
CW732_RS06870	COG0745	RESPONSE REGULATOR receiver
CW732_RS06875	COG0784	Response regulator, receiver
CW732_RS06875	COG2205	protein histidine kinase activity
CW732_RS06885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW732_RS06920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CW732_RS06935	COG1160	GTP binding
CW732_RS06970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CW732_RS07000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CW732_RS07005	COG1404	Belongs to the peptidase S8 family
CW732_RS07015	COG2072	flavoprotein involved in K transport
CW732_RS07045	COG0662	Cupin 2, conserved barrel domain protein
CW732_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS07055	COG2827	Endonuclease containing a URI domain
CW732_RS07070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CW732_RS07075	COG3844	kynureninase activity
CW732_RS07100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CW732_RS07105	COG1663	tetraacyldisaccharide 4'-kinase activity
CW732_RS07110	COG2205	protein histidine kinase activity
CW732_RS07110	COG0784	Response regulator, receiver
CW732_RS07115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CW732_RS07120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CW732_RS07130	COG1215	transferase activity, transferring glycosyl groups
CW732_RS07150	COG1595	DNA-templated transcription, initiation
CW732_RS07155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CW732_RS07160	COG0436	Aminotransferase
CW732_RS07180	COG0525	valine-tRNA ligase activity
CW732_RS07200	COG2274	protein secretion by the type I secretion system
CW732_RS07255	COG1215	transferase activity, transferring glycosyl groups
CW732_RS07285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CW732_RS07290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW732_RS07290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CW732_RS07310	COG1090	epimerase
CW732_RS07340	COG1510	regulation of RNA biosynthetic process
CW732_RS07350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CW732_RS07355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CW732_RS07360	COG0563	adenylate kinase activity
CW732_RS07365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CW732_RS07395	COG3275	phosphorelay sensor kinase activity
CW732_RS07405	COG1629	transport
CW732_RS07415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CW732_RS07575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CW732_RS07580	COG1115	amino acid carrier protein
CW732_RS07590	COG1960	acyl-CoA dehydrogenase activity
CW732_RS07600	COG0366	Alpha amylase catalytic
CW732_RS07605	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CW732_RS07610	COG4974	Belongs to the 'phage' integrase family
CW732_RS07615	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CW732_RS07660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CW732_RS07665	COG0081	regulation of translation
CW732_RS07670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CW732_RS07675	COG0222	ribosome binding
CW732_RS07680	COG0085	RNA polymerase activity
CW732_RS07685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CW732_RS07695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CW732_RS07715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CW732_RS07745	COG1073	alpha beta
CW732_RS07770	COG1733	regulation of RNA biosynthetic process
CW732_RS07775	COG2353	YceI-like domain
CW732_RS07780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CW732_RS07785	COG0484	heat shock protein binding
CW732_RS07790	COG4152	abc transporter atp-binding protein
CW732_RS07795	COG1668	transmembrane transport
CW732_RS07800	COG3264	Mechanosensitive ion channel
CW732_RS07800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CW732_RS07820	COG2326	polyphosphate kinase activity
CW732_RS07845	COG2204	response regulator
CW732_RS07850	COG3447	MASE1 domain protein
CW732_RS07850	COG5001	Diguanylate cyclase
CW732_RS07850	COG5002	protein histidine kinase activity
CW732_RS07865	COG0045	succinate-CoA ligase (ADP-forming) activity
CW732_RS07875	COG0556	nucleotide-excision repair
CW732_RS07920	COG1612	heme a metabolic process
CW732_RS07930	COG0617	tRNA 3'-terminal CCA addition
CW732_RS07935	COG0009	L-threonylcarbamoyladenylate synthase
CW732_RS07990	COG0463	Glycosyl transferase, family 2
CW732_RS08005	COG2171	N-acyltransferase activity
CW732_RS08010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CW732_RS08015	COG0242	peptide deformylase activity
CW732_RS08025	COG3956	TIGRFAM MazG family protein
CW732_RS08050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CW732_RS08070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW732_RS08080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CW732_RS08105	COG0513	Belongs to the DEAD box helicase family
CW732_RS08115	COG4771	TonB-dependent receptor
CW732_RS08120	COG2010	Cytochrome c
CW732_RS08125	COG1289	transmembrane transporter activity
CW732_RS08135	COG2258	MOSC domain
CW732_RS08165	COG2936	dipeptidyl-peptidase activity
CW732_RS08365	COG2076	Multidrug Resistance protein
CW732_RS08385	COG3220	belongs to the UPF0276 family
CW732_RS08475	COG2249	NAD(P)H dehydrogenase (quinone) activity
CW732_RS08490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CW732_RS08500	COG0326	Molecular chaperone. Has ATPase activity
CW732_RS08525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW732_RS08530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CW732_RS08540	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW732_RS08555	COG0179	Fumarylacetoacetate (FAA) hydrolase
CW732_RS08565	COG1058	Belongs to the CinA family
CW732_RS08565	COG1546	Belongs to the CinA family
CW732_RS08570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CW732_RS08575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CW732_RS08585	COG0552	protein localization to endoplasmic reticulum
CW732_RS08600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW732_RS08605	COG2720	vancomycin resistance protein
CW732_RS08625	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CW732_RS08630	COG0076	glutamate decarboxylase activity
CW732_RS08640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CW732_RS08640	COG0519	Catalyzes the synthesis of GMP from XMP
CW732_RS08655	COG3530	Putative quorum-sensing-regulated virulence factor
CW732_RS08665	COG0504	CTP synthase activity
CW732_RS08670	COG0706	membrane insertase activity
CW732_RS08680	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW732_RS08685	COG0482	sulfurtransferase activity
CW732_RS08705	COG0534	Mate efflux family protein
CW732_RS08715	COG0671	phosphoesterase, PA-phosphatase related
CW732_RS08730	COG0463	Glycosyl transferase, family 2
CW732_RS08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CW732_RS08795	COG1404	Belongs to the peptidase S8 family
CW732_RS08810	COG1703	isobutyryl-CoA mutase activity
CW732_RS08820	COG1595	DNA-templated transcription, initiation
CW732_RS08920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CW732_RS08925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CW732_RS08935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CW732_RS08950	COG0653	protein targeting
CW732_RS08985	COG0488	(ABC) transporter
CW732_RS08995	COG0489	protein tyrosine kinase activity
CW732_RS09035	COG2327	Polysaccharide pyruvyl transferase
CW732_RS09045	COG1216	Glycosyl transferase, family 2
CW732_RS09050	COG1216	Glycosyl transferase, family 2
CW732_RS09085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CW732_RS09090	COG2089	acid synthase
CW732_RS09120	COG1045	serine acetyltransferase
CW732_RS09145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CW732_RS09165	COG1253	flavin adenine dinucleotide binding
CW732_RS09170	COG1137	ATPase activity
CW732_RS09180	COG0805	protein transport
CW732_RS09185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CW732_RS09185	COG0517	IMP dehydrogenase activity
CW732_RS09190	COG0514	ATP-dependent DNA helicase (RecQ)
CW732_RS09200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW732_RS09205	COG2318	DinB family
CW732_RS09215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW732_RS09225	COG1132	(ABC) transporter
CW732_RS09235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW732_RS09245	COG1862	Preprotein translocase
CW732_RS09290	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW732_RS09295	COG0167	dihydroorotate dehydrogenase activity
CW732_RS09355	COG0517	IMP dehydrogenase activity
CW732_RS09355	COG0516	GMP reductase activity
CW732_RS09400	COG0596	Alpha beta hydrolase
CW732_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS09430	COG2267	carboxylic ester hydrolase activity
CW732_RS09435	COG2378	regulation of single-species biofilm formation
CW732_RS09495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW732_RS09505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW732_RS09510	COG0714	Associated with various cellular activities
CW732_RS09520	COG2755	lipolytic protein G-D-S-L family
CW732_RS09520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CW732_RS09540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW732_RS09565	COG1233	COG1233 Phytoene dehydrogenase and related
CW732_RS09590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CW732_RS09595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW732_RS09600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CW732_RS09615	COG3958	Transketolase
CW732_RS09620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CW732_RS09625	COG0343	queuine tRNA-ribosyltransferase activity
CW732_RS09640	COG0825	malonyl-CoA metabolic process
CW732_RS09645	COG0305	Participates in initiation and elongation during chromosome replication
CW732_RS09665	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CW732_RS09670	COG0561	phosphatase activity
CW732_RS09675	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CW732_RS09680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CW732_RS09685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CW732_RS09690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CW732_RS09785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CW732_RS09810	COG0335	large ribosomal subunit rRNA binding
CW732_RS09815	COG0336	Belongs to the RNA methyltransferase TrmD family
CW732_RS09825	COG0488	(ABC) transporter
CW732_RS09835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CW732_RS09860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CW732_RS09870	COG1505	serine-type exopeptidase activity
CW732_RS09875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CW732_RS09895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CW732_RS09900	COG3279	Response regulator of the LytR AlgR family
CW732_RS09905	COG0360	Binds together with S18 to 16S ribosomal RNA
CW732_RS09910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CW732_RS09915	COG0359	binds to the 23S rRNA
CW732_RS09935	COG0124	histidyl-tRNA synthetase
CW732_RS09955	COG1678	Uncharacterized ACR, COG1678
CW732_RS09965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CW732_RS09970	COG0514	ATP-dependent DNA helicase (RecQ)
CW732_RS09990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CW732_RS10060	COG3547	Transposase (IS116 IS110 IS902 family)
CW732_RS10075	COG0415	Belongs to the DNA photolyase family
CW732_RS10090	COG0386	Belongs to the glutathione peroxidase family
CW732_RS10105	COG0302	gtp cyclohydrolase
CW732_RS10120	COG0415	Belongs to the DNA photolyase family
CW732_RS10125	COG3046	protein related to deoxyribodipyrimidine photolyase
CW732_RS10130	COG0415	Belongs to the DNA photolyase family
CW732_RS10140	COG0702	epimerase
CW732_RS10180	COG0456	acetyltransferase
CW732_RS10200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CW732_RS10210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CW732_RS10230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CW732_RS10235	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CW732_RS10240	COG0824	Thioesterase
CW732_RS10245	COG1739	Uncharacterized protein family UPF0029
CW732_RS10255	COG1011	Hydrolase
CW732_RS10335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW732_RS10335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CW732_RS10350	COG2890	protein-(glutamine-N5) methyltransferase activity
CW732_RS10360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CW732_RS10370	COG0737	Belongs to the 5'-nucleotidase family
CW732_RS10385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CW732_RS10410	COG0497	DNA recombination
CW732_RS10415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CW732_RS10440	COG0237	dephospho-CoA kinase activity
CW732_RS10455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CW732_RS10460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW732_RS10465	COG2176	DNA-directed DNA polymerase activity
CW732_RS10475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CW732_RS10485	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW732_RS10490	COG0673	inositol 2-dehydrogenase activity
CW732_RS10495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CW732_RS10565	COG4771	TonB-dependent receptor
CW732_RS10570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CW732_RS10575	COG0456	acetyltransferase
CW732_RS10590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CW732_RS10595	COG0579	oxidoreductase
CW732_RS10615	COG0542	response to heat
CW732_RS10630	COG2095	MarC family integral membrane protein
CW732_RS10635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW732_RS10660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CW732_RS10690	COG0300	oxidoreductase activity
CW732_RS10705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CW732_RS10720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW732_RS10725	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CW732_RS10735	COG0589	response to stress
CW732_RS10765	COG0577	efflux transmembrane transporter activity
CW732_RS10765	COG1136	(ABC) transporter
CW732_RS10770	COG1136	(ABC) transporter
CW732_RS10815	COG0589	response to stress
CW732_RS10830	COG1127	ABC transporter
CW732_RS10835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW732_RS10840	COG2814	Major facilitator Superfamily
CW732_RS10840	COG0477	Major facilitator Superfamily
CW732_RS10950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CW732_RS10955	COG0587	DNA-directed DNA polymerase activity
CW732_RS10970	COG0069	glutamate synthase activity
CW732_RS11005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CW732_RS11010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW732_RS11010	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CW732_RS11025	COG1674	ftsk spoiiie
CW732_RS11030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CW732_RS11040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CW732_RS11045	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CW732_RS11090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CW732_RS11135	COG1846	Transcriptional regulator
CW732_RS11140	COG1673	EVE domain
CW732_RS11165	COG4628	conserved protein (DUF2132)
CW732_RS11170	COG0300	oxidoreductase activity
CW732_RS11180	COG3291	Pkd domain containing protein
CW732_RS11215	COG3118	belongs to the thioredoxin family
CW732_RS11220	COG0450	alkyl hydroperoxide reductase
CW732_RS11225	COG1757	Na H antiporter
CW732_RS11245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW732_RS11270	COG0513	Belongs to the DEAD box helicase family
CW732_RS11290	COG0037	tRNA processing
CW732_RS11300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CW732_RS11315	COG0606	chelatase, subunit chli
CW732_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS11350	COG0564	pseudouridine synthase activity
CW732_RS11360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CW732_RS11365	COG1760	l-serine dehydratase
CW732_RS11370	COG0443	Heat shock 70 kDa protein
CW732_RS11375	COG2070	2-Nitropropane dioxygenase
CW732_RS11385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CW732_RS11390	COG1652	LysM domain
CW732_RS11390	COG2823	Periplasmic or secreted lipoprotein
CW732_RS11400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CW732_RS11405	COG0540	Belongs to the ATCase OTCase family
CW732_RS11415	COG1234	tRNA 3'-trailer cleavage
CW732_RS11425	COG0259	pyridoxamine-phosphate oxidase activity
CW732_RS11455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CW732_RS11480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CW732_RS11490	COG0742	ribosomal rna small subunit methyltransferase
CW732_RS11505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CW732_RS11510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CW732_RS11525	COG1454	alcohol dehydrogenase
CW732_RS11540	COG1234	tRNA 3'-trailer cleavage
CW732_RS11560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CW732_RS11580	COG4251	negative regulation of phosphorylation
CW732_RS11600	COG1136	(ABC) transporter
CW732_RS11610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW732_RS11615	COG0302	gtp cyclohydrolase
CW732_RS11715	COG2378	regulation of single-species biofilm formation
CW732_RS11755	COG0583	DNA-binding transcription factor activity
CW732_RS11795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CW732_RS11800	COG0083	homoserine kinase activity
CW732_RS11805	COG0527	aspartate kinase activity
CW732_RS11805	COG0460	homoserine dehydrogenase
CW732_RS11810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CW732_RS11815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW732_RS11820	COG2986	histidine ammonia-lyase
CW732_RS11830	COG0542	response to heat
CW732_RS11835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CW732_RS11845	COG0791	NLP P60 protein
CW732_RS11850	COG0183	Belongs to the thiolase family
CW732_RS11855	COG1480	7TM receptor with intracellular HD hydrolase
CW732_RS11965	COG0628	permease
CW732_RS11970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW732_RS11985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CW732_RS11990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CW732_RS12000	COG0205	6-phosphofructokinase activity
CW732_RS12005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CW732_RS12015	COG1803	Methylglyoxal synthase
CW732_RS12025	COG0251	oxidation-reduction process
CW732_RS12035	COG0860	N-Acetylmuramoyl-L-alanine amidase
CW732_RS12045	COG2181	nitrate reductase activity
CW732_RS12045	COG0247	lactate metabolic process
CW732_RS12060	COG0247	lactate metabolic process
CW732_RS12060	COG2181	nitrate reductase activity
CW732_RS12070	COG3830	Belongs to the UPF0237 family
CW732_RS12070	COG0560	Phosphoserine phosphatase
CW732_RS12080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW732_RS12100	COG1472	Belongs to the glycosyl hydrolase 3 family
CW732_RS12105	COG0438	transferase activity, transferring glycosyl groups
CW732_RS12115	COG2885	chlorophyll binding
CW732_RS12120	COG0247	lactate metabolic process
CW732_RS12120	COG0277	FAD linked oxidase domain protein
CW732_RS12135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CW732_RS12145	COG1301	dicarboxylic acid transport
CW732_RS12150	COG2897	thiosulfate sulfurtransferase activity
CW732_RS12165	COG3011	Protein conserved in bacteria
CW732_RS12175	COG2827	Endonuclease containing a URI domain
CW732_RS12180	COG1193	negative regulation of DNA recombination
CW732_RS12265	COG2197	response regulator
CW732_RS12270	COG4585	Histidine kinase
CW732_RS12355	COG0101	tRNA pseudouridine synthase activity
CW732_RS12390	COG1288	antiporter activity
CW732_RS12400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CW732_RS12410	COG0813	purine-nucleoside phosphorylase activity
CW732_RS12430	COG0022	dehydrogenase e1 component
CW732_RS12460	COG0668	transmembrane transport
CW732_RS12465	COG1187	pseudouridine synthase activity
CW732_RS12510	COG0612	Peptidase, M16
CW732_RS12655	COG3279	Response regulator of the LytR AlgR family
CW732_RS12710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CW732_RS12725	COG0352	thiamine-phosphate diphosphorylase activity
CW732_RS12730	COG2022	thiamine diphosphate biosynthetic process
CW732_RS12735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CW732_RS12770	COG4251	negative regulation of phosphorylation
CW732_RS12785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CW732_RS12830	COG0352	thiamine-phosphate diphosphorylase activity
CW732_RS12865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CW732_RS12885	COG2217	Heavy metal translocating P-type atpase
CW732_RS12890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW732_RS12900	COG3047	cAMP biosynthetic process
CW732_RS12900	COG2885	chlorophyll binding
CW732_RS12925	COG1278	Cold shock
CW732_RS12935	COG0702	epimerase
CW732_RS12960	COG2249	NAD(P)H dehydrogenase (quinone) activity
CW732_RS12965	COG2095	MarC family integral membrane protein
CW732_RS12975	COG2985	domain, Protein
CW732_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS13005	COG1024	Enoyl-CoA hydratase
CW732_RS13010	COG2207	Transcriptional regulator
CW732_RS13025	COG0604	alcohol dehydrogenase
CW732_RS13030	COG0778	Nitroreductase
CW732_RS13040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CW732_RS13070	COG3279	Response regulator of the LytR AlgR family
CW732_RS13090	COG3275	phosphorelay sensor kinase activity
CW732_RS13100	COG0577	efflux transmembrane transporter activity
CW732_RS13100	COG1136	(ABC) transporter
CW732_RS13105	COG1136	(ABC) transporter
CW732_RS13110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CW732_RS13125	COG1064	alcohol dehydrogenase
CW732_RS13130	COG1764	response to oxidative stress
CW732_RS13135	COG1902	pentaerythritol trinitrate reductase activity
CW732_RS13150	COG2197	response regulator
CW732_RS13155	COG3850	Histidine kinase
CW732_RS13165	COG0246	Mannitol dehydrogenase
CW732_RS13170	COG1172	Belongs to the binding-protein-dependent transport system permease family
CW732_RS13200	COG1309	transcriptional regulator
CW732_RS13215	COG1764	response to oxidative stress
CW732_RS13220	COG2130	NADP-dependent
CW732_RS13225	COG1979	alcohol dehydrogenase
CW732_RS13235	COG1278	Cold shock
CW732_RS13240	COG1278	Cold shock
CW732_RS13245	COG1278	Cold shock
CW732_RS13250	COG1278	Cold shock
CW732_RS13255	COG1278	Cold shock
CW732_RS13280	COG1959	2 iron, 2 sulfur cluster binding
CW732_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS13315	COG0513	Belongs to the DEAD box helicase family
CW732_RS13335	COG1278	Cold shock
CW732_RS13385	COG0668	transmembrane transport
CW732_RS13390	COG0783	Belongs to the Dps family
CW732_RS13395	COG0101	tRNA pseudouridine synthase activity
CW732_RS13410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CW732_RS13410	COG0140	phosphoribosyl-ATP diphosphatase activity
CW732_RS13415	COG0107	imidazoleglycerol-phosphate synthase activity
CW732_RS13420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CW732_RS13430	COG0131	Imidazoleglycerol-phosphate dehydratase
CW732_RS13435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CW732_RS13440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CW732_RS13445	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CW732_RS13470	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS13475	COG0612	Peptidase, M16
CW732_RS13480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CW732_RS13490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW732_RS13495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CW732_RS13500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW732_RS13505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CW732_RS13505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CW732_RS13510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CW732_RS13515	COG1078	dGTPase activity
CW732_RS13520	COG2204	response regulator
CW732_RS13545	COG0506	proline dehydrogenase activity
CW732_RS13550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CW732_RS13565	COG1522	sequence-specific DNA binding
CW732_RS13585	COG0861	Integral membrane protein TerC family
CW732_RS13605	COG0012	GTP binding
CW732_RS13610	COG4771	TonB-dependent receptor
CW732_RS13615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CW732_RS13625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CW732_RS13630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CW732_RS13750	COG0024	Methionine aminopeptidase
CW732_RS13770	COG0702	epimerase
CW732_RS13780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CW732_RS13785	COG2066	Belongs to the glutaminase family
CW732_RS13795	COG2154	pterin-4-alpha-carbinolamine dehydratase
CW732_RS13800	COG0793	Belongs to the peptidase S41A family
CW732_RS13805	COG0217	transcriptional regulatory protein
CW732_RS13810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CW732_RS13815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CW732_RS13825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CW732_RS13880	COG0156	8-amino-7-oxononanoate synthase activity
CW732_RS13895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CW732_RS13910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CW732_RS13915	COG1393	Belongs to the ArsC family
CW732_RS13920	COG1393	Belongs to the ArsC family
CW732_RS13945	COG1228	amidohydrolase
CW732_RS14010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CW732_RS14025	COG0488	(ABC) transporter
CW732_RS14035	COG1741	Belongs to the pirin family
CW732_RS14040	COG1846	Transcriptional regulator
CW732_RS14045	COG0431	NADPH-dependent FMN reductase
CW732_RS14050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW732_RS14060	COG1629	transport
CW732_RS14070	COG1266	CAAX protease self-immunity
CW732_RS14075	COG4948	Mandelate Racemase Muconate Lactonizing
CW732_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
CW732_RS14085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CW732_RS14090	COG1575	Belongs to the MenA family. Type 1 subfamily
CW732_RS14115	COG2996	Protein conserved in bacteria
CW732_RS14125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CW732_RS14130	COG1169	isochorismate synthase
CW732_RS14155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CW732_RS14180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CW732_RS14185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CW732_RS14215	COG2270	Major facilitator Superfamily
CW732_RS14230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CW732_RS14235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CW732_RS14240	COG0297	glycogen (starch) synthase activity
CW732_RS14245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW732_RS14250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CW732_RS14260	COG1252	NADH dehydrogenase
CW732_RS14265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CW732_RS14270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CW732_RS14280	COG4974	Belongs to the 'phage' integrase family
CW732_RS14285	COG3290	protein histidine kinase activity
CW732_RS14290	COG3290	protein histidine kinase activity
CW732_RS14295	COG1418	mRNA catabolic process
CW732_RS14335	COG1104	cysteine desulfurase activity
CW732_RS14360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CW732_RS14365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CW732_RS14380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CW732_RS14380	COG0116	Belongs to the methyltransferase superfamily
CW732_RS14400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CW732_RS14405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CW732_RS14415	COG1272	protein, Hemolysin III
CW732_RS14425	COG1363	Peptidase, m42
CW732_RS14440	COG2339	peptidase activity
CW732_RS14450	COG0511	ligase activity, forming carbon-carbon bonds
CW732_RS14455	COG0439	Biotin carboxylase
CW732_RS14460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CW732_RS14500	COG2814	Major facilitator Superfamily
CW732_RS14505	COG2095	MarC family integral membrane protein
CW732_RS14515	COG1858	cytochrome C peroxidase
CW732_RS14540	COG1525	nuclease
CW732_RS14550	COG4585	Histidine kinase
CW732_RS14565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CW732_RS14580	COG2852	Protein conserved in bacteria
CW732_RS14585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CW732_RS14600	COG0745	RESPONSE REGULATOR receiver
CW732_RS14605	COG5002	protein histidine kinase activity
CW732_RS14615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CW732_RS14640	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS14645	COG2207	Transcriptional regulator
CW732_RS14710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CW732_RS14725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CW732_RS14730	COG1702	phosphate starvation-inducible protein PhoH
CW732_RS14760	COG0592	DNA-directed DNA polymerase activity
CW732_RS14835	COG4771	TonB-dependent receptor
CW732_RS14880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CW732_RS14885	COG1335	isochorismatase
CW732_RS14895	COG0842	Transport permease protein
CW732_RS14900	COG0842	Transport permease protein
CW732_RS14920	COG1131	(ABC) transporter
CW732_RS14925	COG1131	(ABC) transporter
CW732_RS14955	COG1294	oxidase, subunit
CW732_RS14960	COG1271	oxidase subunit
CW732_RS14965	COG0450	alkyl hydroperoxide reductase
CW732_RS14970	COG0500	methyltransferase
CW732_RS14975	COG3118	belongs to the thioredoxin family
CW732_RS14990	COG1054	Belongs to the UPF0176 family
CW732_RS14995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CW732_RS14995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW732_RS15000	COG0730	response to heat
CW732_RS15020	COG4251	negative regulation of phosphorylation
CW732_RS15030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CW732_RS15040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CW732_RS15045	COG0589	response to stress
CW732_RS15060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CW732_RS15090	COG0348	domain, Protein
CW732_RS15130	COG1472	Belongs to the glycosyl hydrolase 3 family
CW732_RS15145	COG0702	epimerase
CW732_RS15150	COG4771	TonB-dependent receptor
CW732_RS15280	COG0542	response to heat
CW732_RS15305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CW732_RS15310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW732_RS15315	COG2204	response regulator
CW732_RS15320	COG3852	Histidine kinase
CW732_RS15350	COG3604	Transcriptional regulator
CW732_RS15385	COG2205	protein histidine kinase activity
CW732_RS15385	COG2202	Pas domain
CW732_RS15390	COG0303	'Molybdopterin
CW732_RS15405	COG0746	molybdenum cofactor guanylyltransferase activity
CW732_RS15415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CW732_RS15425	COG0315	cyclic pyranopterin monophosphate synthase activity
CW732_RS15425	COG0521	Mo-molybdopterin cofactor biosynthetic process
CW732_RS15430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CW732_RS15445	COG0243	molybdopterin cofactor binding
CW732_RS15450	COG2223	nitrite transmembrane transporter activity
CW732_RS15460	COG4585	Histidine kinase
CW732_RS15475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CW732_RS15480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW732_RS15480	COG1648	precorrin-2 dehydrogenase activity
CW732_RS15485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CW732_RS15485	COG1648	precorrin-2 dehydrogenase activity
CW732_RS15505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CW732_RS15510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CW732_RS15515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CW732_RS15535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW732_RS15550	COG0405	Gamma-glutamyltransferase
CW732_RS15565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CW732_RS15570	COG1611	Belongs to the LOG family
CW732_RS15580	COG0022	dehydrogenase e1 component
CW732_RS15600	COG0693	protein deglycase activity
CW732_RS15640	COG0009	L-threonylcarbamoyladenylate synthase
CW732_RS15655	COG0069	glutamate synthase activity
CW732_RS15675	COG2972	Histidine kinase
CW732_RS15675	COG0745	RESPONSE REGULATOR receiver
CW732_RS15705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW732_RS15720	COG0308	aminopeptidase N
CW732_RS15725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CW732_RS15730	COG1231	oxidoreductase activity
CW732_RS15825	COG2207	Transcriptional regulator
CW732_RS15825	COG0662	Cupin 2, conserved barrel domain protein
CW732_RS15850	COG0072	phenylalanine-tRNA ligase activity
CW732_RS15850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CW732_RS15865	COG0488	(ABC) transporter
CW732_RS15910	COG4942	peptidase
CW732_RS15955	COG2249	NAD(P)H dehydrogenase (quinone) activity
CW732_RS15975	COG4585	Histidine kinase
CW732_RS15990	COG0071	Belongs to the small heat shock protein (HSP20) family
CW732_RS16030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CW732_RS16035	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CW732_RS16040	COG0626	cystathionine gamma-synthase activity
CW732_RS16065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CW732_RS16065	COG1333	cytochrome c biogenesis protein
CW732_RS16110	COG0424	maF-like protein
CW732_RS16125	COG0598	Magnesium transport protein CorA
CW732_RS16170	COG0798	PFAM Bile acid sodium symporter
CW732_RS16215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CW732_RS16265	COG4206	TonB-dependent receptor
CW732_RS16275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CW732_RS16280	COG1120	ATPase activity
CW732_RS16285	COG1322	Protein conserved in bacteria
CW732_RS16295	COG1607	acyl-coa hydrolase
CW732_RS16305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW732_RS16315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW732_RS16340	COG0463	Glycosyl transferase, family 2
CW732_RS16340	COG1216	Glycosyl transferase, family 2
CW732_RS16345	COG0562	UDP-galactopyranose mutase
CW732_RS16350	COG0641	radical SAM
CW732_RS16360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CW732_RS16370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CW732_RS16375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CW732_RS16385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CW732_RS16405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CW732_RS16410	COG0747	negative chemotaxis
CW732_RS16435	COG0254	rRNA binding
CW732_RS16450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CW732_RS16455	COG1132	(ABC) transporter
CW732_RS16550	COG1595	DNA-templated transcription, initiation
CW732_RS16555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CW732_RS16555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CW732_RS16565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CW732_RS16565	COG0047	phosphoribosylformylglycinamidine synthase activity
CW732_RS16575	COG1022	Amp-dependent synthetase and ligase
CW732_RS16585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CW732_RS16585	COG1024	Enoyl-CoA hydratase
CW732_RS16590	COG0183	Belongs to the thiolase family
CW732_RS16595	COG1960	acyl-CoA dehydrogenase activity
CW732_RS16630	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CW732_RS16665	COG4206	TonB-dependent receptor
CW732_RS16700	COG3275	phosphorelay sensor kinase activity
CW732_RS16755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW732_RS16780	COG3547	Transposase (IS116 IS110 IS902 family)
CW732_RS16850	COG0783	Belongs to the Dps family
CW732_RS16920	COG0492	ferredoxin-NADP+ reductase activity
CW732_RS16945	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS16965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW732_RS16975	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW732_RS16975	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW732_RS16985	COG0657	acetylesterase activity
CW732_RS17010	COG3420	alginic acid biosynthetic process
CW732_RS17015	COG1192	Involved in chromosome partitioning
CW732_RS17020	COG1475	DNA binding
CW732_RS17030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CW732_RS17065	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CW732_RS17080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CW732_RS17090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CW732_RS17105	COG1278	Cold shock
CW732_RS17110	COG1278	Cold shock
CW732_RS17115	COG0105	UTP biosynthetic process
CW732_RS17130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CW732_RS17140	COG0564	pseudouridine synthase activity
CW732_RS17225	COG2267	carboxylic ester hydrolase activity
CW732_RS17235	COG0697	spore germination
CW732_RS17250	COG2195	Cleaves the N-terminal amino acid of tripeptides
CW732_RS17270	COG1228	amidohydrolase
CW732_RS17275	COG2827	Endonuclease containing a URI domain
CW732_RS17290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CW732_RS17295	COG0501	Belongs to the peptidase M48B family
CW732_RS17300	COG0598	Magnesium transport protein CorA
CW732_RS17320	COG1090	epimerase
CW732_RS17335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CW732_RS17365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CW732_RS17375	COG2814	Major facilitator Superfamily
CW732_RS17385	COG4977	sequence-specific DNA binding
CW732_RS17390	COG1522	sequence-specific DNA binding
CW732_RS17405	COG1595	DNA-templated transcription, initiation
CW732_RS17425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW732_RS17425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CW732_RS17425	COG1703	isobutyryl-CoA mutase activity
CW732_RS17430	COG0788	formyltetrahydrofolate deformylase activity
CW732_RS17445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CW732_RS17450	COG0284	orotidine-5'-phosphate decarboxylase activity
CW732_RS17460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CW732_RS17470	COG1129	ABC transporter
CW732_RS17485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CW732_RS17495	COG1462	curli production assembly transport component CsgG
CW732_RS17525	COG0174	glutamine synthetase
CW732_RS17545	COG2356	endonuclease I
CW732_RS17550	COG0668	transmembrane transport
CW732_RS17590	COG2264	protein methyltransferase activity
CW732_RS17595	COG0149	triose-phosphate isomerase activity
CW732_RS17600	COG0601	transmembrane transport
CW732_RS17615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CW732_RS17635	COG1132	(ABC) transporter
CW732_RS17640	COG0101	tRNA pseudouridine synthase activity
CW732_RS17660	COG0268	Binds directly to 16S ribosomal RNA
CW732_RS17670	COG0442	prolyl-tRNA aminoacylation
CW732_RS17695	COG0302	gtp cyclohydrolase
CW732_RS17700	COG0215	cysteine-tRNA ligase activity
CW732_RS17705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CW732_RS17710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CW732_RS17720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CW732_RS17740	COG0039	L-malate dehydrogenase activity
CW732_RS17745	COG0187	DNA topoisomerase II activity
CW732_RS17750	COG0784	Response regulator, receiver
CW732_RS17750	COG2205	protein histidine kinase activity
CW732_RS17755	COG0367	asparagine synthase
CW732_RS17765	COG0602	queuosine metabolic process
CW732_RS17770	COG0433	COG0433 Predicted ATPase
CW732_RS17780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CW732_RS17780	COG0662	Cupin 2, conserved barrel domain protein
CW732_RS17805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CW732_RS17810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CW732_RS17865	COG0596	Alpha beta hydrolase
CW732_RS17925	COG0148	phosphopyruvate hydratase activity
CW732_RS17930	COG0505	Belongs to the CarA family
CW732_RS17935	COG0203	ribosomal protein L17
CW732_RS17940	COG0202	RNA polymerase activity
CW732_RS17945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CW732_RS17950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CW732_RS17955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CW732_RS17960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CW732_RS17965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CW732_RS17975	COG0200	Binds to the 23S rRNA
CW732_RS17980	COG1841	ribosomal large subunit assembly
CW732_RS17985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CW732_RS17990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CW732_RS17995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CW732_RS18000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CW732_RS18005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CW732_RS18010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CW732_RS18015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CW732_RS18020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CW732_RS18025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CW732_RS18030	COG0255	Belongs to the universal ribosomal protein uL29 family
CW732_RS18035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CW732_RS18040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CW732_RS18045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CW732_RS18050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CW732_RS18055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CW732_RS18060	COG0089	rRNA binding
CW732_RS18065	COG0088	Forms part of the polypeptide exit tunnel
CW732_RS18070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CW732_RS18075	COG0051	transcription antitermination factor activity, RNA binding
CW732_RS18080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CW732_RS18085	COG0049	tRNA binding
CW732_RS18090	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CW732_RS18100	COG4771	TonB-dependent receptor
CW732_RS18110	COG4771	TonB-dependent receptor
CW732_RS18145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CW732_RS18155	COG1011	Hydrolase
CW732_RS18165	COG2003	Belongs to the UPF0758 family
CW732_RS18180	COG1047	Peptidyl-prolyl cis-trans
CW732_RS18190	COG0577	efflux transmembrane transporter activity
CW732_RS18195	COG3876	Protein conserved in bacteria
CW732_RS18230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CW732_RS18245	COG2884	Cell division ATP-binding protein ftsE
CW732_RS18255	COG1216	Glycosyl transferase, family 2
CW732_RS18275	COG2244	polysaccharide biosynthetic process
CW732_RS18300	COG1217	gtp-binding protein TYPA
CW732_RS18320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CW732_RS18365	COG2949	membrane
CW732_RS18410	COG1629	transport
CW732_RS18420	COG0641	radical SAM
CW732_RS18470	COG1459	type II secretion system
CW732_RS18585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW732_RS18590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CW732_RS18595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CW732_RS18600	COG0512	Glutamine amidotransferase of anthranilate synthase
CW732_RS18605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CW732_RS18610	COG0134	indole-3-glycerol-phosphate synthase activity
CW732_RS18615	COG0135	phosphoribosylanthranilate isomerase activity
CW732_RS18620	COG0133	tryptophan synthase activity
CW732_RS18625	COG2827	Endonuclease containing a URI domain
CW732_RS18630	COG0159	tryptophan synthase activity
CW732_RS18645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CW732_RS18650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CW732_RS18655	COG4628	conserved protein (DUF2132)
CW732_RS18665	COG0513	Belongs to the DEAD box helicase family
CW732_RS18695	COG2197	response regulator
CW732_RS18855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CW732_RS18910	COG3022	response to hydroperoxide
CW732_RS18915	COG0564	pseudouridine synthase activity
CW732_RS18920	COG2815	serine threonine protein kinase
CW732_RS18920	COG0515	serine threonine protein kinase
CW732_RS18925	COG1181	Belongs to the D-alanine--D-alanine ligase family
CW732_RS18935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CW732_RS18940	COG0659	secondary active sulfate transmembrane transporter activity
CW732_RS18950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CW732_RS18950	COG3153	acetyltransferase
CW732_RS18980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CW732_RS18995	COG0799	negative regulation of ribosome biogenesis
CW732_RS19000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CW732_RS19010	COG4589	Belongs to the CDS family
CW732_RS19015	COG0688	phosphatidylethanolamine metabolic process
CW732_RS19025	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
CW732_RS19030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CW732_RS19035	COG1127	ABC transporter
CW732_RS19070	COG1301	dicarboxylic acid transport
CW732_RS19075	COG1012	belongs to the aldehyde dehydrogenase family
CW732_RS19095	COG1595	DNA-templated transcription, initiation
CW732_RS19105	COG1629	transport
CW732_RS19105	COG4206	TonB-dependent receptor
CW732_RS19150	COG0018	arginyl-trna synthetase
CW732_RS19155	COG2205	protein histidine kinase activity
CW732_RS19190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CW732_RS19195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CW732_RS19200	COG0295	cytidine deaminase activity
CW732_RS19220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CW732_RS19240	COG0443	Heat shock 70 kDa protein
CW732_RS19250	COG0285	dihydrofolate synthase activity
CW732_RS19260	COG0848	biopolymer transport protein
CW732_RS19265	COG0811	peptide transport
CW732_RS19275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CW732_RS19285	COG1960	acyl-CoA dehydrogenase activity
CW732_RS19290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD