locus-tag	class	description
DN609_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DN609_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DN609_RS00030	COG0187	DNA topoisomerase II activity
DN609_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DN609_RS00075	COG1217	gtp-binding protein TYPA
DN609_RS00080	COG2860	membrane
DN609_RS00100	COG0360	Binds together with S18 to 16S ribosomal RNA
DN609_RS00110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DN609_RS00120	COG0359	binds to the 23S rRNA
DN609_RS00130	COG0305	Participates in initiation and elongation during chromosome replication
DN609_RS00135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DN609_RS00190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DN609_RS00195	COG0137	argininosuccinate synthase activity
DN609_RS00200	COG0165	Argininosuccinate lyase
DN609_RS00205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DN609_RS00220	COG0745	RESPONSE REGULATOR receiver
DN609_RS00225	COG2205	protein histidine kinase activity
DN609_RS00230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DN609_RS00250	COG0515	serine threonine protein kinase
DN609_RS00250	COG2815	serine threonine protein kinase
DN609_RS00260	COG0631	protein serine/threonine phosphatase activity
DN609_RS00270	COG1716	ATPase activity
DN609_RS00275	COG2815	serine threonine protein kinase
DN609_RS00275	COG0515	serine threonine protein kinase
DN609_RS00290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DN609_RS00295	COG1132	(ABC) transporter
DN609_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DN609_RS00315	COG4509	Sortase family
DN609_RS00325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DN609_RS00330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DN609_RS00335	COG2188	Transcriptional regulator
DN609_RS00350	COG3414	Phosphotransferase system galactitol-specific IIB component
DN609_RS00355	COG3775	system Galactitol-specific IIC component
DN609_RS00370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS00375	COG1349	DNA-binding transcription factor activity
DN609_RS00395	COG3775	system Galactitol-specific IIC component
DN609_RS00420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DN609_RS00430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN609_RS00440	COG1253	flavin adenine dinucleotide binding
DN609_RS00465	COG2239	Acts as a magnesium transporter
DN609_RS00475	COG0590	tRNA wobble adenosine to inosine editing
DN609_RS00485	COG1704	LemA family
DN609_RS00490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DN609_RS00495	COG3842	ATPase activity
DN609_RS00505	COG0395	ABC-type sugar transport system, permease component
DN609_RS00520	COG0513	Belongs to the DEAD box helicase family
DN609_RS00565	COG0622	Phosphoesterase
DN609_RS00570	COG0443	Heat shock 70 kDa protein
DN609_RS00575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DN609_RS00580	COG0484	heat shock protein binding
DN609_RS00585	COG0789	Transcriptional regulator
DN609_RS00595	COG0542	response to heat
DN609_RS00615	COG0071	Belongs to the small heat shock protein (HSP20) family
DN609_RS00620	COG1105	Belongs to the carbohydrate kinase PfkB family
DN609_RS00630	COG1349	DNA-binding transcription factor activity
DN609_RS00645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS00650	COG3715	PTS system
DN609_RS00655	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS00660	COG2188	Transcriptional regulator
DN609_RS00665	COG2222	sugar isomerase
DN609_RS00680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DN609_RS00690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DN609_RS00690	COG0037	tRNA processing
DN609_RS00695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN609_RS00700	COG0436	Aminotransferase
DN609_RS00720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DN609_RS00725	COG0708	Exodeoxyribonuclease III
DN609_RS00735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DN609_RS00750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DN609_RS00765	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DN609_RS00770	COG2890	protein-(glutamine-N5) methyltransferase activity
DN609_RS00775	COG0698	ribose 5-phosphate isomerase
DN609_RS00780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DN609_RS00790	COG0356	it plays a direct role in the translocation of protons across the membrane
DN609_RS00800	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DN609_RS00805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DN609_RS00810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DN609_RS00815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DN609_RS00820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DN609_RS00830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DN609_RS00835	COG1316	TRANSCRIPTIONal
DN609_RS00845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN609_RS00880	COG3973	AAA domain
DN609_RS00890	COG0463	Glycosyl transferase, family 2
DN609_RS00905	COG1737	Transcriptional regulator
DN609_RS00925	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS00930	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DN609_RS00935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DN609_RS00940	COG2376	Dihydroxyacetone kinase
DN609_RS00975	COG0561	phosphatase activity
DN609_RS00980	COG1201	RNA secondary structure unwinding
DN609_RS00985	COG0531	amino acid
DN609_RS01030	COG1047	Peptidyl-prolyl cis-trans
DN609_RS01040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DN609_RS01045	COG1307	EDD domain protein, DegV family
DN609_RS01050	COG3875	lactate racemase activity
DN609_RS01055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DN609_RS01060	COG2801	Transposase and inactivated derivatives
DN609_RS01075	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DN609_RS01080	COG1691	(AIR) carboxylase
DN609_RS01090	COG0747	negative chemotaxis
DN609_RS01095	COG0601	transmembrane transport
DN609_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN609_RS01110	COG1124	(ABC) transporter
DN609_RS01140	COG1595	DNA-templated transcription, initiation
DN609_RS01150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DN609_RS01155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DN609_RS01165	COG0473	3-isopropylmalate dehydrogenase activity
DN609_RS01170	COG0561	phosphatase activity
DN609_RS01175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN609_RS01185	COG0602	queuosine metabolic process
DN609_RS01190	COG0745	RESPONSE REGULATOR receiver
DN609_RS01195	COG2205	protein histidine kinase activity
DN609_RS01205	COG1328	CTP reductase activity
DN609_RS01210	COG0436	Aminotransferase
DN609_RS01225	COG0514	ATP-dependent DNA helicase (RecQ)
DN609_RS01230	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DN609_RS01235	COG1122	ATPase activity
DN609_RS01260	COG1307	EDD domain protein, DegV family
DN609_RS01265	COG2814	Major facilitator Superfamily
DN609_RS01270	COG1136	(ABC) transporter
DN609_RS01270	COG0577	efflux transmembrane transporter activity
DN609_RS01285	COG0138	bifunctional purine biosynthesis protein purh
DN609_RS01290	COG1971	Probably functions as a manganese efflux pump
DN609_RS01300	COG0765	amino acid transport
DN609_RS01305	COG1126	abc transporter atp-binding protein
DN609_RS01310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DN609_RS01345	COG3142	Participates in the control of copper homeostasis
DN609_RS01355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DN609_RS01360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DN609_RS01370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DN609_RS01375	COG3958	Transketolase
DN609_RS01405	COG0252	asparaginase activity
DN609_RS01410	COG0765	amino acid transport
DN609_RS01420	COG0561	phosphatase activity
DN609_RS01450	COG1045	serine acetyltransferase
DN609_RS01490	COG0646	methionine synthase
DN609_RS01490	COG1410	methionine synthase
DN609_RS01495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DN609_RS01515	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DN609_RS01520	COG1940	carbohydrate kinase activity
DN609_RS01535	COG2188	Transcriptional regulator
DN609_RS01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS01540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS01540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS01550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DN609_RS01560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN609_RS01565	COG0436	Aminotransferase
DN609_RS01585	COG0697	spore germination
DN609_RS01605	COG1482	cell wall glycoprotein biosynthetic process
DN609_RS01615	COG1686	Belongs to the peptidase S11 family
DN609_RS01620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DN609_RS01625	COG0072	phenylalanine-tRNA ligase activity
DN609_RS01650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN609_RS01670	COG1162	GTPase activity
DN609_RS01690	COG0489	protein tyrosine kinase activity
DN609_RS01760	COG1254	Belongs to the acylphosphatase family
DN609_RS01775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN609_RS01790	COG0372	Belongs to the citrate synthase family
DN609_RS01795	COG3158	transport of potassium into the cell
DN609_RS01805	COG0116	Belongs to the methyltransferase superfamily
DN609_RS01805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DN609_RS01810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN609_RS01820	COG1438	arginine binding
DN609_RS01825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DN609_RS01830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DN609_RS01835	COG0826	peptidase U32
DN609_RS01840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DN609_RS01845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DN609_RS01895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DN609_RS01900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DN609_RS01905	COG1116	anion transmembrane transporter activity
DN609_RS01910	COG1362	aminopeptidase activity
DN609_RS01930	COG2801	Transposase and inactivated derivatives
DN609_RS01935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DN609_RS01945	COG1696	Membrane protein involved in D-alanine export
DN609_RS01950	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DN609_RS01955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DN609_RS01960	COG1959	2 iron, 2 sulfur cluster binding
DN609_RS01965	COG0822	iron-sulfur transferase activity
DN609_RS01970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN609_RS01980	COG0719	Fe-S assembly protein
DN609_RS01985	COG0396	ATPase activity
DN609_RS01995	COG0385	Bile acid
DN609_RS02000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DN609_RS02005	COG0154	amidase activity
DN609_RS02010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DN609_RS02020	COG4120	Belongs to the binding-protein-dependent transport system permease family
DN609_RS02025	COG1116	anion transmembrane transporter activity
DN609_RS02040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN609_RS02045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DN609_RS02070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DN609_RS02070	COG0493	'glutamate synthase
DN609_RS02085	COG3845	ABC transporter
DN609_RS02090	COG4603	Belongs to the binding-protein-dependent transport system permease family
DN609_RS02095	COG1079	Belongs to the binding-protein-dependent transport system permease family
DN609_RS02110	COG1744	ABC transporter substrate-binding protein PnrA-like
DN609_RS02115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN609_RS02120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DN609_RS02125	COG2080	2 iron, 2 sulfur cluster binding
DN609_RS02140	COG2252	PERMEase
DN609_RS02145	COG0402	S-adenosylhomocysteine deaminase activity
DN609_RS02155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN609_RS02160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DN609_RS02165	COG0549	Belongs to the carbamate kinase family
DN609_RS02180	COG0251	oxidation-reduction process
DN609_RS02185	COG1970	mechanosensitive ion channel activity
DN609_RS02195	COG0425	Belongs to the sulfur carrier protein TusA family
DN609_RS02210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DN609_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
DN609_RS02275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DN609_RS02285	COG0124	histidyl-tRNA synthetase
DN609_RS02290	COG0564	pseudouridine synthase activity
DN609_RS02310	COG0726	polysaccharide deacetylase
DN609_RS02315	COG1132	(ABC) transporter
DN609_RS02345	COG0539	negative regulation of cytoplasmic translation
DN609_RS02350	COG0747	negative chemotaxis
DN609_RS02360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN609_RS02370	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN609_RS02375	COG1363	Peptidase, m42
DN609_RS02390	COG1966	Carbon starvation protein
DN609_RS02395	COG2801	Transposase and inactivated derivatives
DN609_RS02415	COG1136	(ABC) transporter
DN609_RS02435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS02440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS02440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS02440	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DN609_RS02450	COG1929	Belongs to the glycerate kinase type-1 family
DN609_RS02455	COG0318	PFAM AMP-dependent synthetase and ligase
DN609_RS02465	COG1250	3-hydroxyacyl-CoA dehydrogenase
DN609_RS02475	COG1979	alcohol dehydrogenase
DN609_RS02500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN609_RS02515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DN609_RS02520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DN609_RS02525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DN609_RS02530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DN609_RS02535	COG0426	domain, Protein
DN609_RS02540	COG2270	Major facilitator Superfamily
DN609_RS02565	COG0561	phosphatase activity
DN609_RS02575	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DN609_RS02590	COG0024	Methionine aminopeptidase
DN609_RS02600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DN609_RS02605	COG0242	peptide deformylase activity
DN609_RS02610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DN609_RS02655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DN609_RS02660	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DN609_RS02705	COG0067	glutamate synthase
DN609_RS02705	COG0069	glutamate synthase activity
DN609_RS02705	COG0070	glutamate synthase
DN609_RS02710	COG0493	'glutamate synthase
DN609_RS02735	COG3842	ATPase activity
DN609_RS02745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DN609_RS02750	COG0140	phosphoribosyl-ATP diphosphatase activity
DN609_RS02765	COG0322	excinuclease ABC activity
DN609_RS02770	COG0747	negative chemotaxis
DN609_RS02775	COG0601	transmembrane transport
DN609_RS02780	COG0444	Belongs to the ABC transporter superfamily
DN609_RS02785	COG4608	Belongs to the ABC transporter superfamily
DN609_RS02800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN609_RS02810	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DN609_RS02820	COG1349	DNA-binding transcription factor activity
DN609_RS02825	COG1105	Belongs to the carbohydrate kinase PfkB family
DN609_RS02830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS02830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DN609_RS02830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS02840	COG1481	regulation of sporulation
DN609_RS02850	COG4166	transmembrane transport
DN609_RS02865	COG1363	Peptidase, m42
DN609_RS02875	COG0126	phosphoglycerate kinase activity
DN609_RS02885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN609_RS02890	COG4166	transmembrane transport
DN609_RS02895	COG0601	transmembrane transport
DN609_RS02900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DN609_RS02905	COG0444	Belongs to the ABC transporter superfamily
DN609_RS02910	COG4608	Belongs to the ABC transporter superfamily
DN609_RS02965	COG1104	cysteine desulfurase activity
DN609_RS02970	COG0482	sulfurtransferase activity
DN609_RS03185	COG2801	Transposase and inactivated derivatives
DN609_RS03190	COG2826	transposase and inactivated derivatives, IS30 family
DN609_RS03240	COG1088	dTDP-glucose 4,6-dehydratase activity
DN609_RS03245	COG0561	phosphatase activity
DN609_RS03250	COG0328	RNA-DNA hybrid ribonuclease activity
DN609_RS03255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN609_RS03255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DN609_RS03260	COG0745	RESPONSE REGULATOR receiver
DN609_RS03265	COG2205	protein histidine kinase activity
DN609_RS03270	COG1136	(ABC) transporter
DN609_RS03280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DN609_RS03295	COG1827	regulation of RNA biosynthetic process
DN609_RS03305	COG2801	Transposase and inactivated derivatives
DN609_RS03315	COG1472	Belongs to the glycosyl hydrolase 3 family
DN609_RS03345	COG1181	Belongs to the D-alanine--D-alanine ligase family
DN609_RS03350	COG2183	response to ionizing radiation
DN609_RS03375	COG2217	Heavy metal translocating P-type atpase
DN609_RS03380	COG2217	Heavy metal translocating P-type atpase
DN609_RS03385	COG0640	Transcriptional regulator
DN609_RS03395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DN609_RS03400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN609_RS03410	COG2080	2 iron, 2 sulfur cluster binding
DN609_RS03410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DN609_RS03420	COG1132	(ABC) transporter
DN609_RS03435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN609_RS03435	COG1918	ferrous iron import across plasma membrane
DN609_RS03450	COG1302	Protein conserved in bacteria
DN609_RS03455	COG1461	Dihydroxyacetone kinase
DN609_RS03460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DN609_RS03465	COG0742	ribosomal rna small subunit methyltransferase
DN609_RS03470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DN609_RS03485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DN609_RS03490	COG0416	fatty acid biosynthetic process
DN609_RS03495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN609_RS03500	COG0571	ribonuclease III activity
DN609_RS03510	COG0552	protein localization to endoplasmic reticulum
DN609_RS03515	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DN609_RS03530	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DN609_RS03535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DN609_RS03545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN609_RS03560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DN609_RS03565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DN609_RS03570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN609_RS03585	COG0546	phosphoglycolate phosphatase activity
DN609_RS03620	COG1216	Glycosyl transferase, family 2
DN609_RS03665	COG1376	ErfK ybiS ycfS ynhG family protein
DN609_RS03675	COG0697	spore germination
DN609_RS03680	COG4750	Nucleotidyl transferase
DN609_RS03705	COG3475	LICD family
DN609_RS03715	COG1216	Glycosyl transferase, family 2
DN609_RS03720	COG1216	Glycosyl transferase, family 2
DN609_RS03740	COG1216	Glycosyl transferase, family 2
DN609_RS03745	COG1216	Glycosyl transferase, family 2
DN609_RS03745	COG1442	glycosyl transferase family 8
DN609_RS03750	COG1216	Glycosyl transferase, family 2
DN609_RS03765	COG1278	Cold shock
DN609_RS03770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DN609_RS03780	COG0028	Belongs to the TPP enzyme family
DN609_RS03785	COG0129	dihydroxy-acid dehydratase activity
DN609_RS03790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DN609_RS03795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DN609_RS03810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN609_RS03830	COG0018	arginyl-trna synthetase
DN609_RS03870	COG0411	ABC transporter
DN609_RS03895	COG0460	homoserine dehydrogenase
DN609_RS03900	COG0527	aspartate kinase activity
DN609_RS03905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DN609_RS03910	COG0596	Alpha beta hydrolase
DN609_RS03920	COG0564	pseudouridine synthase activity
DN609_RS03925	COG1215	transferase activity, transferring glycosyl groups
DN609_RS03930	COG0517	IMP dehydrogenase activity
DN609_RS03930	COG0516	GMP reductase activity
DN609_RS03935	COG1472	Belongs to the glycosyl hydrolase 3 family
DN609_RS03955	COG0495	leucyl-tRNA aminoacylation
DN609_RS03965	COG0779	Required for maturation of 30S ribosomal subunits
DN609_RS03970	COG0195	Participates in both transcription termination and antitermination
DN609_RS03975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DN609_RS03975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DN609_RS03980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DN609_RS03995	COG0196	riboflavin kinase activity
DN609_RS04000	COG0358	DNA primase activity
DN609_RS04005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DN609_RS04035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DN609_RS04040	COG0540	Belongs to the ATCase OTCase family
DN609_RS04045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DN609_RS04060	COG0284	orotidine-5'-phosphate decarboxylase activity
DN609_RS04070	COG0194	GDP metabolic process
DN609_RS04080	COG0301	tRNA thio-modification
DN609_RS04085	COG1555	photosystem II stabilization
DN609_RS04085	COG1596	polysaccharide export
DN609_RS04090	COG0658	competence protein
DN609_RS04090	COG2333	competence protein COMEC
DN609_RS04100	COG0268	Binds directly to 16S ribosomal RNA
DN609_RS04105	COG0481	GTPase activity
DN609_RS04110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN609_RS04115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DN609_RS04125	COG0484	heat shock protein binding
DN609_RS04130	COG0484	heat shock protein binding
DN609_RS04135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN609_RS04150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DN609_RS04155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DN609_RS04160	COG1381	Involved in DNA repair and RecF pathway recombination
DN609_RS04165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DN609_RS04170	COG1185	polyribonucleotide nucleotidyltransferase activity
DN609_RS04190	COG1666	GTP binding
DN609_RS04195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN609_RS04200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DN609_RS04205	COG1058	Belongs to the CinA family
DN609_RS04205	COG1546	Belongs to the CinA family
DN609_RS04210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DN609_RS04215	COG2137	regulation of response to DNA damage stimulus
DN609_RS04220	COG1418	mRNA catabolic process
DN609_RS04230	COG2359	stage V sporulation protein S
DN609_RS04235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DN609_RS04240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DN609_RS04245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DN609_RS04255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DN609_RS04270	COG0756	dUTP diphosphatase activity
DN609_RS04280	COG0492	ferredoxin-NADP+ reductase activity
DN609_RS04295	COG1388	LysM domain
DN609_RS04295	COG0791	NLP P60 protein
DN609_RS04300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DN609_RS04575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN609_RS04585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DN609_RS04585	COG0731	radical SAM domain protein
DN609_RS04605	COG0488	(ABC) transporter
DN609_RS04610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DN609_RS04615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DN609_RS04625	COG1104	cysteine desulfurase activity
DN609_RS04630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DN609_RS04635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DN609_RS04640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DN609_RS04645	COG1160	GTP binding
DN609_RS04655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DN609_RS04670	COG1187	pseudouridine synthase activity
DN609_RS04675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DN609_RS04680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DN609_RS04685	COG1994	Peptidase M50
DN609_RS04695	COG0488	(ABC) transporter
DN609_RS04700	COG2755	lipolytic protein G-D-S-L family
DN609_RS04700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DN609_RS04740	COG0436	Aminotransferase
DN609_RS04745	COG1304	FMN binding
DN609_RS04750	COG0442	prolyl-tRNA aminoacylation
DN609_RS04755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DN609_RS04760	COG0750	zinc metalloprotease
DN609_RS04765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DN609_RS04770	COG4589	Belongs to the CDS family
DN609_RS04775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DN609_RS04780	COG0233	cytoplasmic translational termination
DN609_RS04785	COG0528	UMP kinase activity
DN609_RS04795	COG0052	Belongs to the universal ribosomal protein uS2 family
DN609_RS04800	COG4974	Belongs to the 'phage' integrase family
DN609_RS04805	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DN609_RS04810	COG0758	DNA mediated transformation
DN609_RS04815	COG0606	chelatase, subunit chli
DN609_RS04820	COG0792	nuclease activity
DN609_RS04830	COG0335	large ribosomal subunit rRNA binding
DN609_RS04840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DN609_RS04845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DN609_RS04845	COG0574	Belongs to the PEP-utilizing enzyme family
DN609_RS04850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DN609_RS04855	COG0751	glycine-tRNA ligase activity
DN609_RS04860	COG0752	glycyl-tRNA synthetase alpha subunit
DN609_RS04870	COG0336	Belongs to the RNA methyltransferase TrmD family
DN609_RS04890	COG0745	RESPONSE REGULATOR receiver
DN609_RS04900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DN609_RS04905	COG0799	negative regulation of ribosome biogenesis
DN609_RS04915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DN609_RS04920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DN609_RS04925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DN609_RS04930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DN609_RS04935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DN609_RS04940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DN609_RS04960	COG0772	Belongs to the SEDS family
DN609_RS04965	COG0768	penicillin binding
DN609_RS04980	COG1077	Cell shape determining protein MreB Mrl
DN609_RS04990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DN609_RS05000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN609_RS05010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DN609_RS05015	COG0287	Prephenate dehydrogenase
DN609_RS05020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DN609_RS05025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DN609_RS05030	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DN609_RS05035	COG0077	Prephenate dehydratase
DN609_RS05035	COG1605	Chorismate mutase
DN609_RS05040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DN609_RS05045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DN609_RS05050	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DN609_RS05055	COG0180	Tryptophanyl-tRNA synthetase
DN609_RS05225	COG1196	nuclear chromosome segregation
DN609_RS05245	COG3617	BRO family, N-terminal domain
DN609_RS05270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DN609_RS05275	COG2235	arginine
DN609_RS05280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DN609_RS05285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DN609_RS05290	COG1141	Ferredoxin
DN609_RS05310	COG0280	phosphate acetyltransferase
DN609_RS05320	COG1131	(ABC) transporter
DN609_RS05350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DN609_RS05360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DN609_RS05390	COG1131	(ABC) transporter
DN609_RS05410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DN609_RS05415	COG1126	abc transporter atp-binding protein
DN609_RS05420	COG0765	amino acid transport
DN609_RS05425	COG0765	amino acid transport
DN609_RS05430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN609_RS05455	COG1570	exodeoxyribonuclease VII activity
DN609_RS05460	COG2738	Putative neutral zinc metallopeptidase
DN609_RS05465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DN609_RS05470	COG1597	lipid kinase activity
DN609_RS05470	COG1803	Methylglyoxal synthase
DN609_RS05475	COG0673	inositol 2-dehydrogenase activity
DN609_RS05515	COG1012	belongs to the aldehyde dehydrogenase family
DN609_RS05515	COG1454	alcohol dehydrogenase
DN609_RS05525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DN609_RS05535	COG0285	dihydrofolate synthase activity
DN609_RS05540	COG0302	gtp cyclohydrolase
DN609_RS05545	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DN609_RS05550	COG3404	Formiminotransferase-cyclodeaminase
DN609_RS05555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DN609_RS05565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN609_RS05575	COG3618	amidohydrolase
DN609_RS05590	COG2721	sulfolactate sulfo-lyase activity
DN609_RS05595	COG1414	Transcriptional regulator
DN609_RS05600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DN609_RS05605	COG0525	valine-tRNA ligase activity
DN609_RS05610	COG0084	hydrolase, TatD family'
DN609_RS05620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DN609_RS05625	COG0740	serine-type endopeptidase activity
DN609_RS05630	COG0544	peptidyl-prolyl cis-trans isomerase activity
DN609_RS05640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DN609_RS05645	COG0505	Belongs to the CarA family
DN609_RS05650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DN609_RS05665	COG1597	lipid kinase activity
DN609_RS05675	COG1105	Belongs to the carbohydrate kinase PfkB family
DN609_RS05685	COG0494	nUDIX hydrolase
DN609_RS05710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DN609_RS05715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DN609_RS05720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DN609_RS05740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN609_RS05745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DN609_RS05750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DN609_RS05750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DN609_RS05755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN609_RS05760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DN609_RS05765	COG0343	queuine tRNA-ribosyltransferase activity
DN609_RS05770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS05785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DN609_RS05795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN609_RS05795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN609_RS05805	COG5002	protein histidine kinase activity
DN609_RS05820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DN609_RS05825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DN609_RS05830	COG0581	inorganic phosphate transmembrane transporter activity
DN609_RS05835	COG0573	inorganic phosphate transmembrane transporter activity
DN609_RS05840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DN609_RS05850	COG1132	(ABC) transporter
DN609_RS05880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DN609_RS05895	COG2255	four-way junction helicase activity
DN609_RS05900	COG0632	four-way junction helicase activity
DN609_RS05905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DN609_RS05915	COG2033	superoxide reductase activity
DN609_RS05920	COG0587	DNA-directed DNA polymerase activity
DN609_RS05940	COG1950	PFAM Membrane protein of
DN609_RS05950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DN609_RS05955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN609_RS05965	COG0583	DNA-binding transcription factor activity
DN609_RS05970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN609_RS05975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DN609_RS05995	COG2197	response regulator
DN609_RS06020	COG0205	6-phosphofructokinase activity
DN609_RS06025	COG1285	pathogenesis
DN609_RS06045	COG0583	DNA-binding transcription factor activity
DN609_RS06050	COG3426	butyrate kinase activity
DN609_RS06055	COG0280	phosphate acetyltransferase
DN609_RS06100	COG0493	'glutamate synthase
DN609_RS06105	COG3976	FMN-binding domain protein
DN609_RS06105	COG1053	succinate dehydrogenase
DN609_RS06105	COG0431	NADPH-dependent FMN reductase
DN609_RS06125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DN609_RS06130	COG0280	phosphate acetyltransferase
DN609_RS06135	COG3426	butyrate kinase activity
DN609_RS06145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DN609_RS06155	COG1362	aminopeptidase activity
DN609_RS06170	COG0534	Mate efflux family protein
DN609_RS06175	COG1609	Transcriptional regulator
DN609_RS06205	COG1611	Belongs to the LOG family
DN609_RS06215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DN609_RS06225	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DN609_RS06230	COG0497	DNA recombination
DN609_RS06235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DN609_RS06240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DN609_RS06250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DN609_RS06260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DN609_RS06275	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS06280	COG3715	PTS system
DN609_RS06305	COG0647	UMP catabolic process
DN609_RS06310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DN609_RS06330	COG0628	permease
DN609_RS06335	COG1191	sigma factor activity
DN609_RS06360	COG2223	nitrite transmembrane transporter activity
DN609_RS06385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN609_RS06400	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DN609_RS06430	COG0617	tRNA 3'-terminal CCA addition
DN609_RS06435	COG3579	cysteine-type endopeptidase activity
DN609_RS06445	COG2190	(PTS) system
DN609_RS06445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS06445	COG1263	PTS System
DN609_RS06450	COG1739	Uncharacterized protein family UPF0029
DN609_RS06470	COG0762	integral membrane protein
DN609_RS06475	COG1799	cell septum assembly
DN609_RS06480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DN609_RS06490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DN609_RS06500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DN609_RS06505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DN609_RS06510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DN609_RS06515	COG0772	Belongs to the SEDS family
DN609_RS06520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DN609_RS06525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DN609_RS06530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DN609_RS06535	COG0768	penicillin binding
DN609_RS06545	COG0275	rRNA processing
DN609_RS06550	COG2001	Belongs to the MraZ family
DN609_RS06555	COG4974	Belongs to the 'phage' integrase family
DN609_RS06560	COG0504	CTP synthase activity
DN609_RS06595	COG0107	imidazoleglycerol-phosphate synthase activity
DN609_RS06600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DN609_RS06605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DN609_RS06615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DN609_RS06620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DN609_RS06625	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DN609_RS06635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DN609_RS06640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DN609_RS06655	COG0577	efflux transmembrane transporter activity
DN609_RS06655	COG1136	(ABC) transporter
DN609_RS06670	COG1671	Belongs to the UPF0178 family
DN609_RS06690	COG1028	Short-chain dehydrogenase reductase Sdr
DN609_RS06695	COG2223	nitrite transmembrane transporter activity
DN609_RS06700	COG0673	inositol 2-dehydrogenase activity
DN609_RS06710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DN609_RS06720	COG3414	Phosphotransferase system galactitol-specific IIB component
DN609_RS06730	COG0556	nucleotide-excision repair
DN609_RS06740	COG0741	lytic transglycosylase activity
DN609_RS06740	COG1196	nuclear chromosome segregation
DN609_RS06740	COG0739	heme binding
DN609_RS06750	COG1116	anion transmembrane transporter activity
DN609_RS06785	COG1063	alcohol dehydrogenase
DN609_RS06790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN609_RS06795	COG0521	Mo-molybdopterin cofactor biosynthetic process
DN609_RS06810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DN609_RS06815	COG3842	ATPase activity
DN609_RS06820	COG4149	molybdate abc transporter
DN609_RS06830	COG3608	succinylglutamate desuccinylase aspartoacylase
DN609_RS06830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DN609_RS06835	COG3608	succinylglutamate desuccinylase aspartoacylase
DN609_RS06835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DN609_RS06840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DN609_RS06870	COG1914	H( )-stimulated, divalent metal cation uptake system
DN609_RS06890	COG1918	ferrous iron import across plasma membrane
DN609_RS06890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN609_RS06895	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DN609_RS06895	COG1918	ferrous iron import across plasma membrane
DN609_RS06930	COG2084	Dehydrogenase
DN609_RS06935	COG1307	EDD domain protein, DegV family
DN609_RS06940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DN609_RS06950	COG1040	competence protein
DN609_RS06955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DN609_RS06960	COG0546	phosphoglycolate phosphatase activity
DN609_RS06970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS06970	COG2190	(PTS) system
DN609_RS06970	COG1263	PTS System
DN609_RS06975	COG2217	Heavy metal translocating P-type atpase
DN609_RS06980	COG1937	Protein conserved in bacteria
DN609_RS06995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DN609_RS07000	COG0745	RESPONSE REGULATOR receiver
DN609_RS07010	COG0765	amino acid transport
DN609_RS07020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DN609_RS07025	COG0174	glutamine synthetase
DN609_RS07035	COG0588	phosphoglycerate mutase activity
DN609_RS07045	COG2081	HI0933 family
DN609_RS07050	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DN609_RS07060	COG1272	protein, Hemolysin III
DN609_RS07065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DN609_RS07080	COG0038	chloride channel
DN609_RS07090	COG1132	(ABC) transporter
DN609_RS07095	COG1132	(ABC) transporter
DN609_RS07100	COG0084	hydrolase, TatD family'
DN609_RS07105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DN609_RS07110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN609_RS07110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DN609_RS07115	COG2205	protein histidine kinase activity
DN609_RS07120	COG0745	RESPONSE REGULATOR receiver
DN609_RS07125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN609_RS07145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DN609_RS07160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DN609_RS07165	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DN609_RS07175	COG0720	synthase
DN609_RS07180	COG1774	PSP1 C-terminal conserved region
DN609_RS07185	COG0470	DNA polymerase III
DN609_RS07190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DN609_RS07200	COG0805	protein transport
DN609_RS07205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN609_RS07210	COG1366	Belongs to the anti-sigma-factor antagonist family
DN609_RS07220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DN609_RS07230	COG0217	transcriptional regulatory protein
DN609_RS07245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DN609_RS07250	COG3775	system Galactitol-specific IIC component
DN609_RS07255	COG3414	Phosphotransferase system galactitol-specific IIB component
DN609_RS07295	COG1132	(ABC) transporter
DN609_RS07315	COG2815	serine threonine protein kinase
DN609_RS07315	COG0515	serine threonine protein kinase
DN609_RS07345	COG0561	phosphatase activity
DN609_RS07365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DN609_RS07370	COG1302	Protein conserved in bacteria
DN609_RS07385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DN609_RS07395	COG1307	EDD domain protein, DegV family
DN609_RS07400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DN609_RS07405	COG1854	S-ribosylhomocysteine lyase activity
DN609_RS07410	COG3264	Mechanosensitive ion channel
DN609_RS07410	COG1511	domain protein
DN609_RS07415	COG0210	DNA helicase
DN609_RS07420	COG0826	peptidase U32
DN609_RS07425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DN609_RS07465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DN609_RS07495	COG1454	alcohol dehydrogenase
DN609_RS07500	COG1012	belongs to the aldehyde dehydrogenase family
DN609_RS07505	COG2197	response regulator
DN609_RS07510	COG4585	Histidine kinase
DN609_RS07515	COG1131	(ABC) transporter
DN609_RS07530	COG0523	cobalamin synthesis protein
DN609_RS07540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DN609_RS07560	COG1534	Rna-binding protein
DN609_RS07565	COG0742	ribosomal rna small subunit methyltransferase
DN609_RS07570	COG0025	NhaP-type Na H and K H
DN609_RS07580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DN609_RS07595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DN609_RS07610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DN609_RS07615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DN609_RS07625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DN609_RS07635	COG0148	phosphopyruvate hydratase activity
DN609_RS07640	COG0205	6-phosphofructokinase activity
DN609_RS07650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DN609_RS07665	COG0740	serine-type endopeptidase activity
DN609_RS07675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DN609_RS07695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DN609_RS07710	COG1760	l-serine dehydratase
DN609_RS07715	COG1733	regulation of RNA biosynthetic process
DN609_RS07735	COG1401	restriction endodeoxyribonuclease activity
DN609_RS07825	COG0348	domain, Protein
DN609_RS07840	COG5002	protein histidine kinase activity
DN609_RS07855	COG4974	Belongs to the 'phage' integrase family
DN609_RS07875	COG1131	(ABC) transporter
DN609_RS07920	COG0371	Dehydrogenase
DN609_RS07930	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS07935	COG3715	PTS system
DN609_RS07940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS07945	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DN609_RS07955	COG0519	Catalyzes the synthesis of GMP from XMP
DN609_RS07955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DN609_RS07960	COG1316	TRANSCRIPTIONal
DN609_RS07990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS07990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS08000	COG0012	GTP binding
DN609_RS08010	COG0459	protein refolding
DN609_RS08015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DN609_RS08030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DN609_RS08035	COG1126	abc transporter atp-binding protein
DN609_RS08040	COG0765	amino acid transport
DN609_RS08055	COG1472	Belongs to the glycosyl hydrolase 3 family
DN609_RS08070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DN609_RS08105	COG1592	Rubrerythrin
DN609_RS08105	COG1773	rubredoxin
DN609_RS08115	COG1028	Short-chain dehydrogenase reductase Sdr
DN609_RS08125	COG1454	alcohol dehydrogenase
DN609_RS08155	COG3550	peptidyl-serine autophosphorylation
DN609_RS08165	COG0561	phosphatase activity
DN609_RS08175	COG0129	dihydroxy-acid dehydratase activity
DN609_RS08180	COG3775	system Galactitol-specific IIC component
DN609_RS08185	COG3414	Phosphotransferase system galactitol-specific IIB component
DN609_RS08190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS08230	COG2848	UPF0210 protein
DN609_RS08235	COG0300	oxidoreductase activity
DN609_RS08260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DN609_RS08280	COG2855	membrane
DN609_RS08295	COG0802	atpase or kinase
DN609_RS08300	COG1573	uracil-dna glycosylase
DN609_RS08305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DN609_RS08310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DN609_RS08310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DN609_RS08315	COG0736	holo-[acyl-carrier-protein] synthase activity
DN609_RS08320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DN609_RS08325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DN609_RS08330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DN609_RS08335	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DN609_RS08340	COG4667	esterase of the alpha-beta hydrolase superfamily
DN609_RS08360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DN609_RS08370	COG0557	exoribonuclease II activity
DN609_RS08375	COG2177	Part of the ABC transporter FtsEX involved in
DN609_RS08380	COG2884	Cell division ATP-binding protein ftsE
DN609_RS08385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DN609_RS08395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DN609_RS08425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DN609_RS08430	COG1349	DNA-binding transcription factor activity
DN609_RS08435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DN609_RS08440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DN609_RS08445	COG0653	protein targeting
DN609_RS08470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DN609_RS08475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DN609_RS08490	COG4974	Belongs to the 'phage' integrase family
DN609_RS08500	COG0732	type I restriction modification DNA specificity domain
DN609_RS08535	COG0561	phosphatase activity
DN609_RS08540	COG0561	phosphatase activity
DN609_RS08550	COG2195	Cleaves the N-terminal amino acid of tripeptides
DN609_RS08555	COG0281	malic enzyme
DN609_RS08560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DN609_RS08565	COG0142	geranyltranstransferase activity
DN609_RS08575	COG1072	(Pantothenic acid kinase))
DN609_RS08580	COG0493	'glutamate synthase
DN609_RS08580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DN609_RS08585	COG0543	2 iron, 2 sulfur cluster binding
DN609_RS08590	COG0193	aminoacyl-tRNA hydrolase activity
DN609_RS08595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DN609_RS08600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DN609_RS08610	COG1216	Glycosyl transferase, family 2
DN609_RS08615	COG1216	Glycosyl transferase, family 2
DN609_RS08640	COG0203	ribosomal protein L17
DN609_RS08645	COG0202	RNA polymerase activity
DN609_RS08650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DN609_RS08655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DN609_RS08660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DN609_RS08670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DN609_RS08680	COG0563	adenylate kinase activity
DN609_RS08690	COG0200	Binds to the 23S rRNA
DN609_RS08695	COG1841	ribosomal large subunit assembly
DN609_RS08700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DN609_RS08705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DN609_RS08710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DN609_RS08715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DN609_RS08730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DN609_RS08735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DN609_RS08740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DN609_RS08745	COG0255	Belongs to the universal ribosomal protein uL29 family
DN609_RS08755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DN609_RS08760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DN609_RS08765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DN609_RS08770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DN609_RS08775	COG0089	rRNA binding
DN609_RS08780	COG0088	Forms part of the polypeptide exit tunnel
DN609_RS08785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DN609_RS08790	COG0588	phosphoglycerate mutase activity
DN609_RS08795	COG0051	transcription antitermination factor activity, RNA binding
DN609_RS08800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DN609_RS08805	COG0049	tRNA binding
DN609_RS08810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DN609_RS08820	COG0493	'glutamate synthase
DN609_RS08830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DN609_RS08835	COG0085	RNA polymerase activity
DN609_RS08840	COG0222	ribosome binding
DN609_RS08845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DN609_RS08855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DN609_RS08865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DN609_RS08875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DN609_RS08880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DN609_RS08910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DN609_RS08915	COG0215	cysteine-tRNA ligase activity
DN609_RS08930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DN609_RS08935	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DN609_RS08945	COG2801	Transposase and inactivated derivatives
DN609_RS08955	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DN609_RS08960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DN609_RS08965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DN609_RS08970	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DN609_RS08995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DN609_RS09010	COG0363	glucosamine-6-phosphate deaminase activity
DN609_RS09015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DN609_RS09020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DN609_RS09050	COG3177	Filamentation induced by cAMP protein fic
DN609_RS09060	COG0640	Transcriptional regulator
DN609_RS09085	COG3956	TIGRFAM MazG family protein
DN609_RS09090	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS09095	COG3715	PTS system
DN609_RS09120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DN609_RS09125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DN609_RS09130	COG0366	Alpha amylase catalytic
DN609_RS09130	COG3103	Sh3 type 3 domain protein
DN609_RS09135	COG0297	glycogen (starch) synthase activity
DN609_RS09140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DN609_RS09150	COG0058	SHG alpha-glucan phosphorylase activity
DN609_RS09155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DN609_RS09165	COG1592	Rubrerythrin
DN609_RS09170	COG1194	a g-specific adenine glycosylase
DN609_RS09195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DN609_RS09200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DN609_RS09225	COG1472	Belongs to the glycosyl hydrolase 3 family
DN609_RS09230	COG3279	Response regulator of the LytR AlgR family
DN609_RS09245	COG0586	Pfam SNARE associated Golgi protein
DN609_RS09270	COG3118	belongs to the thioredoxin family
DN609_RS09275	COG0671	phosphoesterase, PA-phosphatase related
DN609_RS09285	COG3279	Response regulator of the LytR AlgR family
DN609_RS09290	COG3275	phosphorelay sensor kinase activity
DN609_RS09310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DN609_RS09310	COG1013	pyruvate-flavodoxin oxidoreductase activity
DN609_RS09310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DN609_RS09310	COG0674	pyruvate-flavodoxin oxidoreductase activity
DN609_RS09325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DN609_RS09345	COG3716	PTS system mannose fructose sorbose family IID component
DN609_RS09350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DN609_RS09370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DN609_RS09410	COG1199	ATP-dependent helicase activity
DN609_RS09415	COG1181	Belongs to the D-alanine--D-alanine ligase family
DN609_RS09420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DN609_RS09430	COG1475	DNA binding
DN609_RS09435	COG1192	Involved in chromosome partitioning
DN609_RS09440	COG0357	Ribosomal RNA small subunit methyltransferase G
DN609_RS09445	COG1847	R3H domain protein
DN609_RS09455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DN609_RS09460	COG0594	ribonuclease P activity
DN609_RS09465	COG0230	Belongs to the bacterial ribosomal protein bL34 family