locus-tag	class	description
INP52_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INP52_RS00015	COG0592	DNA-directed DNA polymerase activity
INP52_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INP52_RS00030	COG0187	DNA topoisomerase II activity
INP52_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INP52_RS00070	COG1217	gtp-binding protein TYPA
INP52_RS00075	COG2860	membrane
INP52_RS00095	COG0360	Binds together with S18 to 16S ribosomal RNA
INP52_RS00100	COG0629	single-stranded DNA binding
INP52_RS00105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INP52_RS00115	COG0359	binds to the 23S rRNA
INP52_RS00120	COG0305	Participates in initiation and elongation during chromosome replication
INP52_RS00125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INP52_RS00130	COG1307	EDD domain protein, DegV family
INP52_RS00135	COG0151	Belongs to the GarS family
INP52_RS00150	COG1132	(ABC) transporter
INP52_RS00175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INP52_RS00180	COG4509	Sortase family
INP52_RS00195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
INP52_RS00200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INP52_RS00215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INP52_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INP52_RS00230	COG0039	L-malate dehydrogenase activity
INP52_RS00250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INP52_RS00255	COG0426	domain, Protein
INP52_RS00260	COG1253	flavin adenine dinucleotide binding
INP52_RS00290	COG2239	Acts as a magnesium transporter
INP52_RS00300	COG1704	LemA family
INP52_RS00310	COG0590	tRNA wobble adenosine to inosine editing
INP52_RS00315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INP52_RS00320	COG3842	ATPase activity
INP52_RS00325	COG1175	transmembrane transport
INP52_RS00330	COG0395	ABC-type sugar transport system, permease component
INP52_RS00335	COG1653	transport
INP52_RS00350	COG0513	Belongs to the DEAD box helicase family
INP52_RS00355	COG1464	Belongs to the NlpA lipoprotein family
INP52_RS00360	COG2011	ABC-type metal ion transport system permease component
INP52_RS00370	COG4989	oxidoreductase activity
INP52_RS00385	COG0622	Phosphoesterase
INP52_RS00390	COG0443	Heat shock 70 kDa protein
INP52_RS00395	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INP52_RS00405	COG0789	Transcriptional regulator
INP52_RS00410	COG1737	Transcriptional regulator
INP52_RS00420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS00420	COG1263	PTS System
INP52_RS00430	COG0542	response to heat
INP52_RS00450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INP52_RS00500	COG0071	Belongs to the small heat shock protein (HSP20) family
INP52_RS00505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INP52_RS00525	COG0037	tRNA processing
INP52_RS00530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
INP52_RS00530	COG0037	tRNA processing
INP52_RS00535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INP52_RS00550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
INP52_RS00555	COG0708	Exodeoxyribonuclease III
INP52_RS00565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INP52_RS00585	COG0254	rRNA binding
INP52_RS00595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INP52_RS00600	COG2890	protein-(glutamine-N5) methyltransferase activity
INP52_RS00610	COG0698	ribose 5-phosphate isomerase
INP52_RS00615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INP52_RS00620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INP52_RS00630	COG0356	it plays a direct role in the translocation of protons across the membrane
INP52_RS00640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INP52_RS00645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INP52_RS00650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INP52_RS00655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INP52_RS00660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INP52_RS00670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INP52_RS00680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
INP52_RS00685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INP52_RS00730	COG0653	protein targeting
INP52_RS00735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INP52_RS00740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INP52_RS00745	COG1349	DNA-binding transcription factor activity
INP52_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS00790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INP52_RS00800	COG3958	Transketolase
INP52_RS00805	COG2884	Cell division ATP-binding protein ftsE
INP52_RS00810	COG2177	Part of the ABC transporter FtsEX involved in
INP52_RS00815	COG0557	exoribonuclease II activity
INP52_RS00825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INP52_RS00850	COG4667	esterase of the alpha-beta hydrolase superfamily
INP52_RS00860	COG2188	Transcriptional regulator
INP52_RS00865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INP52_RS00870	COG1914	H( )-stimulated, divalent metal cation uptake system
INP52_RS00875	COG0656	L-ascorbic acid biosynthetic process
INP52_RS00885	COG4120	Belongs to the binding-protein-dependent transport system permease family
INP52_RS00910	COG0242	peptide deformylase activity
INP52_RS00915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INP52_RS00925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INP52_RS00935	COG0436	Aminotransferase
INP52_RS00960	COG0191	fructose-bisphosphate aldolase activity
INP52_RS00980	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS00995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INP52_RS01000	COG0431	NADPH-dependent FMN reductase
INP52_RS01005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INP52_RS01010	COG0514	ATP-dependent DNA helicase (RecQ)
INP52_RS01020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INP52_RS01025	COG1122	ATPase activity
INP52_RS01040	COG1846	Transcriptional regulator
INP52_RS01055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INP52_RS01060	COG1121	(ABC) transporter
INP52_RS01065	COG0803	Belongs to the bacterial solute-binding protein 9 family
INP52_RS01080	COG1136	(ABC) transporter
INP52_RS01080	COG0577	efflux transmembrane transporter activity
INP52_RS01095	COG1126	abc transporter atp-binding protein
INP52_RS01100	COG0765	amino acid transport
INP52_RS01110	COG1971	Probably functions as a manganese efflux pump
INP52_RS01120	COG0446	pyridine nucleotide-disulphide oxidoreductase
INP52_RS01125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INP52_RS01130	COG0778	Nitroreductase
INP52_RS01140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
INP52_RS01145	COG0598	Magnesium transport protein CorA
INP52_RS01185	COG1129	ABC transporter
INP52_RS01190	COG1172	Belongs to the binding-protein-dependent transport system permease family
INP52_RS01210	COG3069	C4-dicarboxylate transmembrane transporter activity
INP52_RS01215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INP52_RS01265	COG1882	Formate acetyltransferase
INP52_RS01270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS01295	COG0765	amino acid transport
INP52_RS01300	COG1126	abc transporter atp-binding protein
INP52_RS01310	COG2195	Cleaves the N-terminal amino acid of tripeptides
INP52_RS01320	COG0561	phosphatase activity
INP52_RS01345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
INP52_RS01405	COG3177	Filamentation induced by cAMP protein fic
INP52_RS01410	COG1902	pentaerythritol trinitrate reductase activity
INP52_RS01425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INP52_RS01435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INP52_RS01440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INP52_RS01445	COG0736	holo-[acyl-carrier-protein] synthase activity
INP52_RS01450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INP52_RS01450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INP52_RS01455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INP52_RS01460	COG1573	uracil-dna glycosylase
INP52_RS01465	COG0802	atpase or kinase
INP52_RS01475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS01480	COG0765	amino acid transport
INP52_RS01485	COG1126	abc transporter atp-binding protein
INP52_RS01495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INP52_RS01500	COG0459	protein refolding
INP52_RS01505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP52_RS01505	COG0493	'glutamate synthase
INP52_RS01510	COG0543	2 iron, 2 sulfur cluster binding
INP52_RS01515	COG0193	aminoacyl-tRNA hydrolase activity
INP52_RS01520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INP52_RS01525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INP52_RS01535	COG1063	alcohol dehydrogenase
INP52_RS01540	COG2213	PTS system mannitol-specific
INP52_RS01540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS01555	COG3409	Peptidoglycan-binding domain 1 protein
INP52_RS01555	COG3773	Cell wall hydrolase
INP52_RS01560	COG0142	geranyltranstransferase activity
INP52_RS01565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INP52_RS01585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INP52_RS01610	COG2848	UPF0210 protein
INP52_RS01660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INP52_RS01670	COG3973	AAA domain
INP52_RS01680	COG0463	Glycosyl transferase, family 2
INP52_RS01730	COG1482	cell wall glycoprotein biosynthetic process
INP52_RS01735	COG1970	mechanosensitive ion channel activity
INP52_RS01740	COG1490	D-aminoacyl-tRNA deacylase activity
INP52_RS01745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
INP52_RS01750	COG1940	carbohydrate kinase activity
INP52_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS01755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS01755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS01760	COG1105	Belongs to the carbohydrate kinase PfkB family
INP52_RS01765	COG1349	DNA-binding transcription factor activity
INP52_RS01790	COG1105	Belongs to the carbohydrate kinase PfkB family
INP52_RS01805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS01810	COG3715	PTS system
INP52_RS01815	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS01820	COG2188	Transcriptional regulator
INP52_RS01825	COG2222	sugar isomerase
INP52_RS01850	COG0601	transmembrane transport
INP52_RS01860	COG0444	Belongs to the ABC transporter superfamily
INP52_RS01865	COG4608	Belongs to the ABC transporter superfamily
INP52_RS01870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INP52_RS01885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INP52_RS01890	COG0072	phenylalanine-tRNA ligase activity
INP52_RS01900	COG1309	transcriptional regulator
INP52_RS01910	COG1151	hydroxylamine reductase activity
INP52_RS01925	COG1373	ATPase (AAA superfamily
INP52_RS01930	COG0469	pyruvate kinase activity
INP52_RS01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INP52_RS01940	COG2204	response regulator
INP52_RS01950	COG1454	alcohol dehydrogenase
INP52_RS01955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INP52_RS01960	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INP52_RS01990	COG1162	GTPase activity
INP52_RS02075	COG1254	Belongs to the acylphosphatase family
INP52_RS02105	COG0372	Belongs to the citrate synthase family
INP52_RS02110	COG3158	transport of potassium into the cell
INP52_RS02130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
INP52_RS02130	COG0116	Belongs to the methyltransferase superfamily
INP52_RS02135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INP52_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
INP52_RS02170	COG1438	arginine binding
INP52_RS02175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INP52_RS02180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INP52_RS02185	COG0826	peptidase U32
INP52_RS02190	COG0316	Belongs to the HesB IscA family
INP52_RS02190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
INP52_RS02195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INP52_RS02220	COG0217	transcriptional regulatory protein
INP52_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
INP52_RS02240	COG1366	Belongs to the anti-sigma-factor antagonist family
INP52_RS02245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INP52_RS02250	COG0805	protein transport
INP52_RS02255	COG1754	DNA topoisomerase type I activity
INP52_RS02255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INP52_RS02260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
INP52_RS02265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INP52_RS02270	COG1774	PSP1 C-terminal conserved region
INP52_RS02275	COG4810	utilization protein
INP52_RS02300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
INP52_RS02305	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
INP52_RS02315	COG1882	Formate acetyltransferase
INP52_RS02320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS02330	COG0849	cell division
INP52_RS02345	COG4869	propanediol catabolic process
INP52_RS02350	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
INP52_RS02360	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
INP52_RS02365	COG1454	alcohol dehydrogenase
INP52_RS02365	COG1012	belongs to the aldehyde dehydrogenase family
INP52_RS02370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
INP52_RS02390	COG0789	Transcriptional regulator
INP52_RS02400	COG0720	synthase
INP52_RS02410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INP52_RS02415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INP52_RS02435	COG0583	DNA-binding transcription factor activity
INP52_RS02440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INP52_RS02440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INP52_RS02445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INP52_RS02450	COG0084	hydrolase, TatD family'
INP52_RS02455	COG1040	competence protein
INP52_RS02465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
INP52_RS02475	COG2084	Dehydrogenase
INP52_RS02500	COG1683	Conserved Protein
INP52_RS02520	COG0306	phosphate transporter
INP52_RS02530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INP52_RS02540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INP52_RS02545	COG0124	histidyl-tRNA synthetase
INP52_RS02555	COG0493	'glutamate synthase
INP52_RS02560	COG1136	(ABC) transporter
INP52_RS02560	COG0577	efflux transmembrane transporter activity
INP52_RS02565	COG1136	(ABC) transporter
INP52_RS02575	COG0564	pseudouridine synthase activity
INP52_RS02585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
INP52_RS02590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INP52_RS02605	COG0726	polysaccharide deacetylase
INP52_RS02630	COG1136	(ABC) transporter
INP52_RS02640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INP52_RS02650	COG3022	response to hydroperoxide
INP52_RS02680	COG2873	o-acetylhomoserine
INP52_RS02690	COG3328	transposase activity
INP52_RS02700	COG2723	6-phospho-beta-galactosidase activity
INP52_RS02705	COG1263	PTS System
INP52_RS02705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS02705	COG2190	(PTS) system
INP52_RS02710	COG3328	transposase activity
INP52_RS02715	COG3715	PTS system
INP52_RS02720	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS02725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS02730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INP52_RS02740	COG2188	Transcriptional regulator
INP52_RS02750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INP52_RS02755	COG1307	EDD domain protein, DegV family
INP52_RS02760	COG1842	Phage shock protein A
INP52_RS02780	COG2816	NAD+ diphosphatase activity
INP52_RS02805	COG1131	(ABC) transporter
INP52_RS02820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
INP52_RS02825	COG1063	alcohol dehydrogenase
INP52_RS02830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS02835	COG1882	Formate acetyltransferase
INP52_RS02840	COG1882	Formate acetyltransferase
INP52_RS02850	COG1472	Belongs to the glycosyl hydrolase 3 family
INP52_RS02860	COG0586	Pfam SNARE associated Golgi protein
INP52_RS02870	COG0431	NADPH-dependent FMN reductase
INP52_RS02875	COG1979	alcohol dehydrogenase
INP52_RS02885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INP52_RS02895	COG1671	Belongs to the UPF0178 family
INP52_RS02910	COG1918	ferrous iron import across plasma membrane
INP52_RS02910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INP52_RS02915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INP52_RS02920	COG1611	Belongs to the LOG family
INP52_RS02925	COG1131	(ABC) transporter
INP52_RS03000	COG1131	(ABC) transporter
INP52_RS03005	COG1725	Transcriptional regulator
INP52_RS03030	COG1362	aminopeptidase activity
INP52_RS03040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INP52_RS03040	COG1918	ferrous iron import across plasma membrane
INP52_RS03045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
INP52_RS03045	COG1918	ferrous iron import across plasma membrane
INP52_RS03060	COG1132	(ABC) transporter
INP52_RS03090	COG0588	phosphoglycerate mutase activity
INP52_RS03100	COG0174	glutamine synthetase
INP52_RS03105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS03110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS03115	COG0765	amino acid transport
INP52_RS03125	COG0745	RESPONSE REGULATOR receiver
INP52_RS03130	COG0488	(ABC) transporter
INP52_RS03135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INP52_RS03140	COG2188	Transcriptional regulator
INP52_RS03160	COG3775	system Galactitol-specific IIC component
INP52_RS03180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS03190	COG1937	Protein conserved in bacteria
INP52_RS03200	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INP52_RS03205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INP52_RS03235	COG0067	glutamate synthase
INP52_RS03235	COG0070	glutamate synthase
INP52_RS03235	COG0069	glutamate synthase activity
INP52_RS03240	COG0493	'glutamate synthase
INP52_RS03285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INP52_RS03285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INP52_RS03310	COG0539	negative regulation of cytoplasmic translation
INP52_RS03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INP52_RS03330	COG0444	Belongs to the ABC transporter superfamily
INP52_RS03335	COG4608	Belongs to the ABC transporter superfamily
INP52_RS03340	COG2195	Cleaves the N-terminal amino acid of tripeptides
INP52_RS03365	COG1116	anion transmembrane transporter activity
INP52_RS03370	COG0237	dephospho-CoA kinase activity
INP52_RS03375	COG0741	lytic transglycosylase activity
INP52_RS03385	COG0556	nucleotide-excision repair
INP52_RS03395	COG3414	Phosphotransferase system galactitol-specific IIB component
INP52_RS03400	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
INP52_RS03425	COG3655	Transcriptional regulator
INP52_RS03435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INP52_RS03440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
INP52_RS03455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INP52_RS03460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INP52_RS03465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INP52_RS03470	COG0131	Imidazoleglycerol-phosphate dehydratase
INP52_RS03475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INP52_RS03480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INP52_RS03485	COG0107	imidazoleglycerol-phosphate synthase activity
INP52_RS03500	COG0140	phosphoribosyl-ATP diphosphatase activity
INP52_RS03510	COG0322	excinuclease ABC activity
INP52_RS03540	COG1940	carbohydrate kinase activity
INP52_RS03545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
INP52_RS03550	COG1733	regulation of RNA biosynthetic process
INP52_RS03555	COG2910	NAD(P)H-binding
INP52_RS03565	COG1481	regulation of sporulation
INP52_RS03575	COG0126	phosphoglycerate kinase activity
INP52_RS03585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INP52_RS03595	COG0601	transmembrane transport
INP52_RS03600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INP52_RS03605	COG0444	Belongs to the ABC transporter superfamily
INP52_RS03610	COG4608	Belongs to the ABC transporter superfamily
INP52_RS03650	COG1104	cysteine desulfurase activity
INP52_RS03655	COG0482	sulfurtransferase activity
INP52_RS03685	COG2222	sugar isomerase
INP52_RS03690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INP52_RS03695	COG4166	transmembrane transport
INP52_RS03700	COG0601	transmembrane transport
INP52_RS03705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
INP52_RS03710	COG0444	Belongs to the ABC transporter superfamily
INP52_RS03715	COG4608	Belongs to the ABC transporter superfamily
INP52_RS03720	COG2188	Transcriptional regulator
INP52_RS03730	COG0569	domain protein
INP52_RS03735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INP52_RS03740	COG0745	RESPONSE REGULATOR receiver
INP52_RS03745	COG2205	protein histidine kinase activity
INP52_RS03760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
INP52_RS03765	COG0523	cobalamin synthesis protein
INP52_RS03775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INP52_RS03790	COG1473	amidohydrolase
INP52_RS03800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INP52_RS03805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INP52_RS03810	COG2171	N-acyltransferase activity
INP52_RS03815	COG1473	amidohydrolase
INP52_RS03825	COG0582	viral genome integration into host DNA
INP52_RS03830	COG0582	viral genome integration into host DNA
INP52_RS03835	COG4974	Belongs to the 'phage' integrase family
INP52_RS03860	COG0582	viral genome integration into host DNA
INP52_RS03900	COG1132	(ABC) transporter
INP52_RS03930	COG1181	Belongs to the D-alanine--D-alanine ligase family
INP52_RS03940	COG1757	Na H antiporter
INP52_RS03945	COG2855	membrane
INP52_RS03955	COG1737	Transcriptional regulator
INP52_RS03960	COG1486	melibiose metabolic process
INP52_RS03965	COG2190	(PTS) system
INP52_RS03965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS03965	COG1263	PTS System
INP52_RS03970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS03970	COG2190	(PTS) system
INP52_RS03970	COG1263	PTS System
INP52_RS03975	COG2217	Heavy metal translocating P-type atpase
INP52_RS03985	COG0640	Transcriptional regulator
INP52_RS04015	COG1966	Carbon starvation protein
INP52_RS04045	COG0450	alkyl hydroperoxide reductase
INP52_RS04050	COG0492	ferredoxin-NADP+ reductase activity
INP52_RS04055	COG1136	(ABC) transporter
INP52_RS04055	COG0577	efflux transmembrane transporter activity
INP52_RS04100	COG4750	Nucleotidyl transferase
INP52_RS04110	COG0706	membrane insertase activity
INP52_RS04115	COG0697	spore germination
INP52_RS04125	COG4750	Nucleotidyl transferase
INP52_RS04130	COG3475	LICD family
INP52_RS04145	COG3475	LICD family
INP52_RS04165	COG0438	transferase activity, transferring glycosyl groups
INP52_RS04165	COG1216	Glycosyl transferase, family 2
INP52_RS04175	COG3409	Peptidoglycan-binding domain 1 protein
INP52_RS04175	COG3757	hydrolase, family 25
INP52_RS04195	COG1088	dTDP-glucose 4,6-dehydratase activity
INP52_RS04205	COG1216	Glycosyl transferase, family 2
INP52_RS04210	COG1216	Glycosyl transferase, family 2
INP52_RS04215	COG0438	transferase activity, transferring glycosyl groups
INP52_RS04215	COG1216	Glycosyl transferase, family 2
INP52_RS04235	COG1278	Cold shock
INP52_RS04260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INP52_RS04265	COG1302	Protein conserved in bacteria
INP52_RS04270	COG1461	Dihydroxyacetone kinase
INP52_RS04275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INP52_RS04280	COG0742	ribosomal rna small subunit methyltransferase
INP52_RS04285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INP52_RS04300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
INP52_RS04305	COG0416	fatty acid biosynthetic process
INP52_RS04310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INP52_RS04315	COG0571	ribonuclease III activity
INP52_RS04320	COG1196	nuclear chromosome segregation
INP52_RS04325	COG0552	protein localization to endoplasmic reticulum
INP52_RS04350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INP52_RS04360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INP52_RS04365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INP52_RS04370	COG0564	pseudouridine synthase activity
INP52_RS04380	COG0517	IMP dehydrogenase activity
INP52_RS04380	COG0516	GMP reductase activity
INP52_RS04385	COG0495	leucyl-tRNA aminoacylation
INP52_RS04395	COG0779	Required for maturation of 30S ribosomal subunits
INP52_RS04400	COG0195	Participates in both transcription termination and antitermination
INP52_RS04405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INP52_RS04425	COG0358	DNA primase activity
INP52_RS04430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INP52_RS04435	COG1307	EDD domain protein, DegV family
INP52_RS04455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INP52_RS04460	COG0540	Belongs to the ATCase OTCase family
INP52_RS04465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INP52_RS04470	COG0543	2 iron, 2 sulfur cluster binding
INP52_RS04475	COG0167	dihydroorotate dehydrogenase activity
INP52_RS04480	COG0284	orotidine-5'-phosphate decarboxylase activity
INP52_RS04490	COG0194	GDP metabolic process
INP52_RS04500	COG0301	tRNA thio-modification
INP52_RS04505	COG1555	photosystem II stabilization
INP52_RS04510	COG2333	competence protein COMEC
INP52_RS04510	COG0658	competence protein
INP52_RS04520	COG0268	Binds directly to 16S ribosomal RNA
INP52_RS04525	COG0481	GTPase activity
INP52_RS04530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
INP52_RS04550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INP52_RS04555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
INP52_RS04560	COG0352	thiamine-phosphate diphosphorylase activity
INP52_RS04565	COG0351	phosphomethylpyrimidine kinase
INP52_RS04575	COG0484	heat shock protein binding
INP52_RS04580	COG0484	heat shock protein binding
INP52_RS04585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INP52_RS04595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INP52_RS04600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
INP52_RS04610	COG1381	Involved in DNA repair and RecF pathway recombination
INP52_RS04615	COG0789	Transcriptional regulator
INP52_RS04625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INP52_RS04630	COG1185	polyribonucleotide nucleotidyltransferase activity
INP52_RS04635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
INP52_RS04650	COG1666	GTP binding
INP52_RS04655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INP52_RS04660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
INP52_RS04680	COG1418	mRNA catabolic process
INP52_RS04690	COG2359	stage V sporulation protein S
INP52_RS04695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INP52_RS04700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INP52_RS04705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INP52_RS04735	COG0756	dUTP diphosphatase activity
INP52_RS04740	COG2252	PERMEase
INP52_RS04745	COG2233	PERMEase
INP52_RS04765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
INP52_RS04795	COG3906	Belongs to the UPF0473 family
INP52_RS04810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INP52_RS04820	COG2084	Dehydrogenase
INP52_RS04825	COG1929	Belongs to the glycerate kinase type-1 family
INP52_RS04830	COG0656	L-ascorbic acid biosynthetic process
INP52_RS04840	COG0385	Bile acid
INP52_RS04865	COG2814	Major facilitator Superfamily
INP52_RS04875	COG1129	ABC transporter
INP52_RS04890	COG0583	DNA-binding transcription factor activity
INP52_RS04895	COG0281	malic enzyme
INP52_RS04925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INP52_RS04930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INP52_RS04960	COG4988	ABC transporter
INP52_RS04970	COG3608	succinylglutamate desuccinylase aspartoacylase
INP52_RS04970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
INP52_RS04975	COG1126	abc transporter atp-binding protein
INP52_RS04980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS05015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS05015	COG3711	transcriptional antiterminator
INP52_RS05020	COG1447	Phosphotransferase system cellobiose-specific component IIA
INP52_RS05030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
INP52_RS05045	COG2814	Major facilitator Superfamily
INP52_RS05050	COG3328	transposase activity
INP52_RS05060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS05065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INP52_RS05065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INP52_RS05090	COG4974	Belongs to the 'phage' integrase family
INP52_RS05100	COG1335	isochorismatase
INP52_RS05110	COG0488	(ABC) transporter
INP52_RS05115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
INP52_RS05120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
INP52_RS05135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INP52_RS05140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INP52_RS05145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
INP52_RS05150	COG1160	GTP binding
INP52_RS05155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
INP52_RS05170	COG1187	pseudouridine synthase activity
INP52_RS05175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
INP52_RS05195	COG0488	(ABC) transporter
INP52_RS05200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
INP52_RS05200	COG2755	lipolytic protein G-D-S-L family
INP52_RS05215	COG1132	(ABC) transporter
INP52_RS05230	COG1304	FMN binding
INP52_RS05235	COG0442	prolyl-tRNA aminoacylation
INP52_RS05240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
INP52_RS05245	COG0750	zinc metalloprotease
INP52_RS05250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
INP52_RS05255	COG0575	Belongs to the CDS family
INP52_RS05260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INP52_RS05265	COG0233	cytoplasmic translational termination
INP52_RS05270	COG0528	UMP kinase activity
INP52_RS05280	COG0052	Belongs to the universal ribosomal protein uS2 family
INP52_RS05285	COG4974	Belongs to the 'phage' integrase family
INP52_RS05290	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
INP52_RS05300	COG0606	chelatase, subunit chli
INP52_RS05305	COG0792	nuclease activity
INP52_RS05315	COG0335	large ribosomal subunit rRNA binding
INP52_RS05325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
INP52_RS05330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
INP52_RS05330	COG0574	Belongs to the PEP-utilizing enzyme family
INP52_RS05335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
INP52_RS05340	COG0751	glycine-tRNA ligase activity
INP52_RS05345	COG0752	glycyl-tRNA synthetase alpha subunit
INP52_RS05355	COG0336	Belongs to the RNA methyltransferase TrmD family
INP52_RS05375	COG0745	RESPONSE REGULATOR receiver
INP52_RS05395	COG1418	mRNA catabolic process
INP52_RS05400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INP52_RS05405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INP52_RS05415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INP52_RS05420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INP52_RS05435	COG0772	Belongs to the SEDS family
INP52_RS05440	COG0768	penicillin binding
INP52_RS05455	COG1077	Cell shape determining protein MreB Mrl
INP52_RS05465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INP52_RS05475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INP52_RS05480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INP52_RS05490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INP52_RS05495	COG0287	Prephenate dehydrogenase
INP52_RS05500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INP52_RS05505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INP52_RS05510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INP52_RS05515	COG0077	Prephenate dehydratase
INP52_RS05515	COG1605	Chorismate mutase
INP52_RS05520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INP52_RS05525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INP52_RS05530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INP52_RS05535	COG0180	Tryptophanyl-tRNA synthetase
INP52_RS05550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INP52_RS05555	COG2235	arginine
INP52_RS05560	COG0456	acetyltransferase
INP52_RS05565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INP52_RS05570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INP52_RS05575	COG3384	dioxygenase
INP52_RS05580	COG1141	Ferredoxin
INP52_RS05585	COG0424	maF-like protein
INP52_RS05590	COG3191	aminopeptidase activity
INP52_RS05600	COG1132	(ABC) transporter
INP52_RS05615	COG1215	transferase activity, transferring glycosyl groups
INP52_RS05625	COG0280	phosphate acetyltransferase
INP52_RS05630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INP52_RS05645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
INP52_RS05650	COG1126	abc transporter atp-binding protein
INP52_RS05655	COG0765	amino acid transport
INP52_RS05660	COG0765	amino acid transport
INP52_RS05665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS05670	COG2190	(PTS) system
INP52_RS05670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS05670	COG1263	PTS System
INP52_RS05675	COG0560	Phosphoserine phosphatase
INP52_RS05685	COG2190	(PTS) system
INP52_RS05685	COG1263	PTS System
INP52_RS05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS05690	COG3711	transcriptional antiterminator
INP52_RS05695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INP52_RS05700	COG0537	adenosine 5'-monophosphoramidase activity
INP52_RS05705	COG1722	exodeoxyribonuclease VII activity
INP52_RS05710	COG1570	exodeoxyribonuclease VII activity
INP52_RS05715	COG2738	Putative neutral zinc metallopeptidase
INP52_RS05720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
INP52_RS05740	COG0673	inositol 2-dehydrogenase activity
INP52_RS05760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INP52_RS05785	COG1454	alcohol dehydrogenase
INP52_RS05785	COG1012	belongs to the aldehyde dehydrogenase family
INP52_RS05790	COG0285	dihydrofolate synthase activity
INP52_RS05805	COG2759	Belongs to the formate--tetrahydrofolate ligase family
INP52_RS05815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INP52_RS05825	COG0302	gtp cyclohydrolase
INP52_RS05830	COG1609	Transcriptional regulator
INP52_RS05835	COG4211	Belongs to the binding-protein-dependent transport system permease family
INP52_RS05840	COG1129	ABC transporter
INP52_RS05845	COG1879	ABC-type sugar transport system periplasmic component
INP52_RS05850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
INP52_RS05865	COG0525	valine-tRNA ligase activity
INP52_RS05875	COG1442	glycosyl transferase family 8
INP52_RS05880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INP52_RS05890	COG0544	peptidyl-prolyl cis-trans isomerase activity
INP52_RS05900	COG0366	Alpha amylase catalytic
INP52_RS05905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS05905	COG1263	PTS System
INP52_RS05910	COG2188	Transcriptional regulator
INP52_RS05920	COG0505	Belongs to the CarA family
INP52_RS05925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INP52_RS05940	COG1597	lipid kinase activity
INP52_RS05950	COG1105	Belongs to the carbohydrate kinase PfkB family
INP52_RS05985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INP52_RS05990	COG0527	aspartate kinase activity
INP52_RS05995	COG0460	homoserine dehydrogenase
INP52_RS06005	COG0083	homoserine kinase activity
INP52_RS06015	COG0411	ABC transporter
INP52_RS06040	COG4221	oxidoreductase activity
INP52_RS06055	COG0018	arginyl-trna synthetase
INP52_RS06060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INP52_RS06075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INP52_RS06085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
INP52_RS06090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INP52_RS06095	COG0129	dihydroxy-acid dehydratase activity
INP52_RS06105	COG0440	acetolactate synthase activity
INP52_RS06110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INP52_RS06115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INP52_RS06120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INP52_RS06125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INP52_RS06130	COG1528	Iron-storage protein
INP52_RS06140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INP52_RS06145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INP52_RS06150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INP52_RS06150	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INP52_RS06160	COG0343	queuine tRNA-ribosyltransferase activity
INP52_RS06165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS06175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INP52_RS06180	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INP52_RS06185	COG0778	Nitroreductase
INP52_RS06195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INP52_RS06195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INP52_RS06215	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS06240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INP52_RS06250	COG2188	Transcriptional regulator
INP52_RS06255	COG2186	Transcriptional regulator
INP52_RS06265	COG5002	protein histidine kinase activity
INP52_RS06270	COG0745	RESPONSE REGULATOR receiver
INP52_RS06280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INP52_RS06285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
INP52_RS06290	COG0581	inorganic phosphate transmembrane transporter activity
INP52_RS06295	COG0573	inorganic phosphate transmembrane transporter activity
INP52_RS06300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
INP52_RS06310	COG1132	(ABC) transporter
INP52_RS06315	COG1132	(ABC) transporter
INP52_RS06320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
INP52_RS06360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INP52_RS06360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INP52_RS06365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INP52_RS06370	COG0242	peptide deformylase activity
INP52_RS06375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INP52_RS06380	COG0577	efflux transmembrane transporter activity
INP52_RS06380	COG1136	(ABC) transporter
INP52_RS06405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INP52_RS06440	COG0617	tRNA 3'-terminal CCA addition
INP52_RS06445	COG3579	cysteine-type endopeptidase activity
INP52_RS06450	COG3579	cysteine-type endopeptidase activity
INP52_RS06455	COG0346	lactoylglutathione lyase activity
INP52_RS06460	COG1739	Uncharacterized protein family UPF0029
INP52_RS06475	COG0762	integral membrane protein
INP52_RS06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INP52_RS06485	COG1799	cell septum assembly
INP52_RS06495	COG1496	oxidoreductase activity
INP52_RS06500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
INP52_RS06505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
INP52_RS06510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INP52_RS06515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INP52_RS06520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INP52_RS06525	COG0772	Belongs to the SEDS family
INP52_RS06530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INP52_RS06535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INP52_RS06540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INP52_RS06545	COG0768	penicillin binding
INP52_RS06555	COG0275	rRNA processing
INP52_RS06570	COG0504	CTP synthase activity
INP52_RS06575	COG0497	DNA recombination
INP52_RS06580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INP52_RS06595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INP52_RS06605	COG2116	formate transmembrane transporter activity
INP52_RS06615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INP52_RS06630	COG3715	PTS system
INP52_RS06650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INP52_RS06655	COG0647	UMP catabolic process
INP52_RS06660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INP52_RS06665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INP52_RS06670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INP52_RS06680	COG0628	permease
INP52_RS06705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
INP52_RS06715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
INP52_RS06730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INP52_RS06735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INP52_RS06740	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
INP52_RS06745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INP52_RS06765	COG0656	L-ascorbic acid biosynthetic process
INP52_RS06770	COG1979	alcohol dehydrogenase
INP52_RS06775	COG0183	Belongs to the thiolase family
INP52_RS06780	COG1250	3-hydroxyacyl-CoA dehydrogenase
INP52_RS06790	COG0318	PFAM AMP-dependent synthetase and ligase
INP52_RS06795	COG1929	Belongs to the glycerate kinase type-1 family
INP52_RS06810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS06810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS06810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS06835	COG2255	four-way junction helicase activity
INP52_RS06840	COG0632	four-way junction helicase activity
INP52_RS06845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INP52_RS06855	COG2033	superoxide reductase activity
INP52_RS06865	COG0587	DNA-directed DNA polymerase activity
INP52_RS06880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
INP52_RS06885	COG1074	ATP-dependent DNA helicase activity
INP52_RS06905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
INP52_RS06910	COG1950	PFAM Membrane protein of
INP52_RS06915	COG1454	alcohol dehydrogenase
INP52_RS06935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INP52_RS06955	COG3715	PTS system
INP52_RS06960	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS06970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INP52_RS06995	COG0765	amino acid transport
INP52_RS07000	COG0205	6-phosphofructokinase activity
INP52_RS07010	COG3426	butyrate kinase activity
INP52_RS07030	COG0183	Belongs to the thiolase family
INP52_RS07060	COG0493	'glutamate synthase
INP52_RS07065	COG0431	NADPH-dependent FMN reductase
INP52_RS07065	COG1053	succinate dehydrogenase
INP52_RS07065	COG3976	FMN-binding domain protein
INP52_RS07075	COG0024	Methionine aminopeptidase
INP52_RS07090	COG0736	holo-[acyl-carrier-protein] synthase activity
INP52_RS07095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
INP52_RS07115	COG1322	Protein conserved in bacteria
INP52_RS07120	COG0038	chloride channel
INP52_RS07135	COG0765	amino acid transport
INP52_RS07140	COG0765	amino acid transport
INP52_RS07145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
INP52_RS07150	COG1126	abc transporter atp-binding protein
INP52_RS07155	COG1132	(ABC) transporter
INP52_RS07160	COG1132	(ABC) transporter
INP52_RS07175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INP52_RS07180	COG0546	phosphoglycolate phosphatase activity
INP52_RS07195	COG1136	(ABC) transporter
INP52_RS07200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
INP52_RS07205	COG2205	protein histidine kinase activity
INP52_RS07210	COG0745	RESPONSE REGULATOR receiver
INP52_RS07220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
INP52_RS07225	COG0521	Mo-molybdopterin cofactor biosynthetic process
INP52_RS07235	COG0315	cyclic pyranopterin monophosphate synthase activity
INP52_RS07250	COG4149	molybdate abc transporter
INP52_RS07260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
INP52_RS07260	COG3608	succinylglutamate desuccinylase aspartoacylase
INP52_RS07265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INP52_RS07270	COG1120	ATPase activity
INP52_RS07275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INP52_RS07280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INP52_RS07295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INP52_RS07300	COG1309	transcriptional regulator
INP52_RS07310	COG3842	ATPase activity
INP52_RS07325	COG0297	glycogen (starch) synthase activity
INP52_RS07345	COG1921	L-seryl-tRNASec selenium transferase activity
INP52_RS07375	COG3118	belongs to the thioredoxin family
INP52_RS07410	COG1924	4 iron, 4 sulfur cluster binding
INP52_RS07415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INP52_RS07425	COG1116	anion transmembrane transporter activity
INP52_RS07430	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
INP52_RS07435	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
INP52_RS07450	COG0425	Belongs to the sulfur carrier protein TusA family
INP52_RS07460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INP52_RS07465	COG0251	oxidation-reduction process
INP52_RS07480	COG0549	Belongs to the carbamate kinase family
INP52_RS07485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INP52_RS07490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INP52_RS07500	COG1744	ABC transporter substrate-binding protein PnrA-like
INP52_RS07505	COG1079	Belongs to the binding-protein-dependent transport system permease family
INP52_RS07510	COG4603	Belongs to the binding-protein-dependent transport system permease family
INP52_RS07515	COG3845	ABC transporter
INP52_RS07530	COG2080	2 iron, 2 sulfur cluster binding
INP52_RS07535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
INP52_RS07540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
INP52_RS07545	COG0402	S-adenosylhomocysteine deaminase activity
INP52_RS07550	COG2252	PERMEase
INP52_RS07560	COG1079	Belongs to the binding-protein-dependent transport system permease family
INP52_RS07565	COG4603	Belongs to the binding-protein-dependent transport system permease family
INP52_RS07570	COG3845	ABC transporter
INP52_RS07585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP52_RS07585	COG0493	'glutamate synthase
INP52_RS07590	COG0402	S-adenosylhomocysteine deaminase activity
INP52_RS07605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
INP52_RS07610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INP52_RS07615	COG0154	amidase activity
INP52_RS07620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
INP52_RS07625	COG4608	Belongs to the ABC transporter superfamily
INP52_RS07630	COG0396	ATPase activity
INP52_RS07635	COG0719	Fe-S assembly protein
INP52_RS07645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INP52_RS07655	COG1959	2 iron, 2 sulfur cluster binding
INP52_RS07670	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
INP52_RS07680	COG1696	Membrane protein involved in D-alanine export
INP52_RS07685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
INP52_RS07700	COG1882	Formate acetyltransferase
INP52_RS07705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS07710	COG1349	DNA-binding transcription factor activity
INP52_RS07720	COG1116	anion transmembrane transporter activity
INP52_RS07725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
INP52_RS07730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
INP52_RS07745	COG4176	ABC-type proline glycine betaine transport system permease component
INP52_RS07750	COG0517	IMP dehydrogenase activity
INP52_RS07750	COG4175	Glycine betaine
INP52_RS07755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INP52_RS07775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INP52_RS07785	COG1307	EDD domain protein, DegV family
INP52_RS07790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
INP52_RS07795	COG1854	S-ribosylhomocysteine lyase activity
INP52_RS07800	COG0668	transmembrane transport
INP52_RS07815	COG1686	Belongs to the peptidase S11 family
INP52_RS07835	COG0697	spore germination
INP52_RS07850	COG0436	Aminotransferase
INP52_RS07855	COG1328	CTP reductase activity
INP52_RS07865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
INP52_RS07870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
INP52_RS07875	COG0346	lactoylglutathione lyase activity
INP52_RS07880	COG0473	3-isopropylmalate dehydrogenase activity
INP52_RS07885	COG0066	3-isopropylmalate dehydratase activity
INP52_RS07890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INP52_RS07895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INP52_RS07910	COG1272	protein, Hemolysin III
INP52_RS07925	COG1827	regulation of RNA biosynthetic process
INP52_RS07940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
INP52_RS07950	COG1201	RNA secondary structure unwinding
INP52_RS07955	COG1741	Belongs to the pirin family
INP52_RS07975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS07975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS07975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
INP52_RS07985	COG1737	Transcriptional regulator
INP52_RS07990	COG0583	DNA-binding transcription factor activity
INP52_RS07995	COG4948	Mandelate Racemase Muconate Lactonizing
INP52_RS08000	COG3069	C4-dicarboxylate transmembrane transporter activity
INP52_RS08020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
INP52_RS08020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INP52_RS08055	COG3475	LICD family
INP52_RS08060	COG1216	Glycosyl transferase, family 2
INP52_RS08125	COG1045	serine acetyltransferase
INP52_RS08135	COG4948	Mandelate Racemase Muconate Lactonizing
INP52_RS08145	COG1063	alcohol dehydrogenase
INP52_RS08155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INP52_RS08160	COG3775	system Galactitol-specific IIC component
INP52_RS08190	COG4868	Belongs to the UPF0371 family
INP52_RS08195	COG0583	DNA-binding transcription factor activity
INP52_RS08210	COG0561	phosphatase activity
INP52_RS08215	COG0252	asparaginase activity
INP52_RS08225	COG1131	(ABC) transporter
INP52_RS08240	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
INP52_RS08245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INP52_RS08265	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS08270	COG3715	PTS system
INP52_RS08275	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS08280	COG2188	Transcriptional regulator
INP52_RS08285	COG1250	3-hydroxyacyl-CoA dehydrogenase
INP52_RS08290	COG0148	phosphopyruvate hydratase activity
INP52_RS08295	COG0205	6-phosphofructokinase activity
INP52_RS08305	COG1393	Belongs to the ArsC family
INP52_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
INP52_RS08350	COG3189	MarR family transcriptional regulator
INP52_RS08365	COG3588	fructose-bisphosphate aldolase
INP52_RS08370	COG0549	Belongs to the carbamate kinase family
INP52_RS08375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
INP52_RS08380	COG2235	arginine
INP52_RS08385	COG1288	antiporter activity
INP52_RS08390	COG2188	Transcriptional regulator
INP52_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
INP52_RS08465	COG0519	Catalyzes the synthesis of GMP from XMP
INP52_RS08465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INP52_RS08470	COG1316	TRANSCRIPTIONal
INP52_RS08475	COG0012	GTP binding
INP52_RS08495	COG1216	Glycosyl transferase, family 2
INP52_RS08500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INP52_RS08505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS08510	COG1882	Formate acetyltransferase
INP52_RS08515	COG2188	Transcriptional regulator
INP52_RS08525	COG2188	Transcriptional regulator
INP52_RS08530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INP52_RS08535	COG1482	cell wall glycoprotein biosynthetic process
INP52_RS08545	COG3715	PTS system
INP52_RS08550	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS08550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS08555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS08560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INP52_RS08565	COG1482	cell wall glycoprotein biosynthetic process
INP52_RS08585	COG1442	glycosyl transferase family 8
INP52_RS08585	COG1216	Glycosyl transferase, family 2
INP52_RS08595	COG0101	tRNA pseudouridine synthase activity
INP52_RS08600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
INP52_RS08605	COG1122	ATPase activity
INP52_RS08610	COG0203	ribosomal protein L17
INP52_RS08615	COG0202	RNA polymerase activity
INP52_RS08620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INP52_RS08625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INP52_RS08630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INP52_RS08640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INP52_RS08655	COG0201	protein transport
INP52_RS08660	COG0200	Binds to the 23S rRNA
INP52_RS08665	COG1841	ribosomal large subunit assembly
INP52_RS08670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INP52_RS08675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INP52_RS08695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INP52_RS08700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INP52_RS08710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INP52_RS08715	COG0255	Belongs to the universal ribosomal protein uL29 family
INP52_RS08725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INP52_RS08730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INP52_RS08735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INP52_RS08740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INP52_RS08745	COG0089	rRNA binding
INP52_RS08750	COG0088	Forms part of the polypeptide exit tunnel
INP52_RS08755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INP52_RS08760	COG0051	transcription antitermination factor activity, RNA binding
INP52_RS08765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INP52_RS08770	COG0049	tRNA binding
INP52_RS08775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INP52_RS08785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
INP52_RS08785	COG0825	malonyl-CoA metabolic process
INP52_RS08790	COG0439	Biotin carboxylase
INP52_RS08795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INP52_RS08800	COG0511	ligase activity, forming carbon-carbon bonds
INP52_RS08805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INP52_RS08815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INP52_RS08830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INP52_RS08845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INP52_RS08850	COG0085	RNA polymerase activity
INP52_RS08865	COG0222	ribosome binding
INP52_RS08870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INP52_RS08875	COG0081	regulation of translation
INP52_RS08880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INP52_RS08885	COG0250	Participates in transcription elongation, termination and antitermination
INP52_RS08890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
INP52_RS08900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INP52_RS08905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INP52_RS08925	COG0742	ribosomal rna small subunit methyltransferase
INP52_RS08945	COG0215	cysteine-tRNA ligase activity
INP52_RS08955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
INP52_RS08960	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
INP52_RS08970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INP52_RS08975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INP52_RS08985	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
INP52_RS08995	COG0583	DNA-binding transcription factor activity
INP52_RS09000	COG1228	amidohydrolase
INP52_RS09010	COG0561	phosphatase activity
INP52_RS09050	COG0363	glucosamine-6-phosphate deaminase activity
INP52_RS09055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INP52_RS09070	COG1079	Belongs to the binding-protein-dependent transport system permease family
INP52_RS09075	COG4603	Belongs to the binding-protein-dependent transport system permease family
INP52_RS09080	COG3845	ABC transporter
INP52_RS09085	COG1744	ABC transporter substrate-binding protein PnrA-like
INP52_RS09090	COG0813	purine-nucleoside phosphorylase activity
INP52_RS09095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
INP52_RS09100	COG1522	sequence-specific DNA binding
INP52_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INP52_RS09105	COG2313	pseudouridylate synthase activity
INP52_RS09115	COG1328	CTP reductase activity
INP52_RS09120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
INP52_RS09135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
INP52_RS09150	COG3328	transposase activity
INP52_RS09155	COG1263	PTS System
INP52_RS09155	COG2190	(PTS) system
INP52_RS09155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS09165	COG2723	6-phospho-beta-galactosidase activity
INP52_RS09180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
INP52_RS09180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS09185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INP52_RS09190	COG3716	PTS system mannose fructose sorbose family IID component
INP52_RS09200	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
INP52_RS09205	COG1609	Transcriptional regulator
INP52_RS09250	COG3956	TIGRFAM MazG family protein
INP52_RS09255	COG2188	Transcriptional regulator
INP52_RS09260	COG2222	sugar isomerase
INP52_RS09290	COG1472	Belongs to the glycosyl hydrolase 3 family
INP52_RS09305	COG0366	Alpha amylase catalytic
INP52_RS09305	COG3103	Sh3 type 3 domain protein
INP52_RS09310	COG0297	glycogen (starch) synthase activity
INP52_RS09315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
INP52_RS09320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
INP52_RS09325	COG0058	SHG alpha-glucan phosphorylase activity
INP52_RS09330	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INP52_RS09340	COG1592	Rubrerythrin
INP52_RS09370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INP52_RS09375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
INP52_RS09385	COG2814	Major facilitator Superfamily
INP52_RS09390	COG0586	Pfam SNARE associated Golgi protein
INP52_RS09410	COG0513	Belongs to the DEAD box helicase family
INP52_RS09435	COG0671	phosphoesterase, PA-phosphatase related
INP52_RS09450	COG3275	phosphorelay sensor kinase activity
INP52_RS09470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INP52_RS09470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
INP52_RS09470	COG1013	pyruvate-flavodoxin oxidoreductase activity
INP52_RS09470	COG0674	pyruvate-flavodoxin oxidoreductase activity
INP52_RS09500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INP52_RS09520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
INP52_RS09530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INP52_RS09545	COG2815	serine threonine protein kinase
INP52_RS09545	COG0515	serine threonine protein kinase
INP52_RS09550	COG1716	ATPase activity
INP52_RS09560	COG0631	protein serine/threonine phosphatase activity
INP52_RS09570	COG0515	serine threonine protein kinase
INP52_RS09570	COG2815	serine threonine protein kinase
INP52_RS09610	COG0792	nuclease activity
INP52_RS09625	COG4619	ABC transporter
INP52_RS09630	COG0390	transport system, permease component
INP52_RS09650	COG0798	PFAM Bile acid sodium symporter
INP52_RS09675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INP52_RS09690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INP52_RS09695	COG2205	protein histidine kinase activity
INP52_RS09700	COG0745	RESPONSE REGULATOR receiver
INP52_RS09715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
INP52_RS09720	COG0165	Argininosuccinate lyase
INP52_RS09750	COG0386	Belongs to the glutathione peroxidase family
INP52_RS09755	COG1846	Transcriptional regulator
INP52_RS09760	COG1268	BioY protein
INP52_RS09785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
INP52_RS09785	COG1199	ATP-dependent helicase activity
INP52_RS09790	COG1181	Belongs to the D-alanine--D-alanine ligase family
INP52_RS09795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INP52_RS09800	COG1475	DNA binding
INP52_RS09805	COG1192	Involved in chromosome partitioning
INP52_RS09810	COG0357	Ribosomal RNA small subunit methyltransferase G
INP52_RS09815	COG1847	R3H domain protein
INP52_RS09825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INP52_RS09830	COG0594	ribonuclease P activity
INP52_RS09835	COG0230	Belongs to the bacterial ribosomal protein bL34 family