locus-tag	class	description
OTBS_RS00015	COG3736	Type IV secretory pathway, component VirB8
OTBS_RS00025	COG2948	multi-organism process
OTBS_RS00075	COG0415	Belongs to the DNA photolyase family
OTBS_RS00080	COG0415	Belongs to the DNA photolyase family
OTBS_RS00085	COG0492	ferredoxin-NADP+ reductase activity
OTBS_RS00095	COG0823	Involved in the tonB-independent uptake of proteins
OTBS_RS00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OTBS_RS00105	COG2226	methyltransferase
OTBS_RS00135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OTBS_RS00160	COG4974	Belongs to the 'phage' integrase family
OTBS_RS00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
OTBS_RS00255	COG0666	response to abiotic stimulus
OTBS_RS00295	COG0582	viral genome integration into host DNA
OTBS_RS00385	COG5464	transposase or invertase
OTBS_RS00445	COG2205	protein histidine kinase activity
OTBS_RS00445	COG0784	Response regulator, receiver
OTBS_RS00675	COG0149	triose-phosphate isomerase activity
OTBS_RS00680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OTBS_RS00710	COG1183	phosphatidylcholine synthase activity
OTBS_RS00725	COG2887	Belongs to the helicase family. UvrD subfamily
OTBS_RS00735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OTBS_RS00740	COG0045	succinate-CoA ligase (ADP-forming) activity
OTBS_RS00745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OTBS_RS00760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OTBS_RS00770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OTBS_RS00775	COG2927	DNA polymerase III (CHI subunit)
OTBS_RS00780	COG0477	Major facilitator Superfamily
OTBS_RS00800	COG1185	polyribonucleotide nucleotidyltransferase activity
OTBS_RS00805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OTBS_RS00820	COG1396	sequence-specific DNA binding
OTBS_RS00855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OTBS_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OTBS_RS00915	COG2835	tetraacyldisaccharide 4'-kinase activity
OTBS_RS00935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OTBS_RS00940	COG0697	spore germination
OTBS_RS00945	COG0477	Major facilitator Superfamily
OTBS_RS00960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OTBS_RS00965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OTBS_RS00970	COG0085	RNA polymerase activity
OTBS_RS00975	COG0222	ribosome binding
OTBS_RS00980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OTBS_RS00985	COG0081	regulation of translation
OTBS_RS00990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OTBS_RS01010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OTBS_RS01020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OTBS_RS01025	COG2917	probably involved in intracellular septation
OTBS_RS01035	COG4633	Protein conserved in bacteria
OTBS_RS01045	COG4943	cyclic-guanylate-specific phosphodiesterase activity
OTBS_RS01050	COG1126	abc transporter atp-binding protein
OTBS_RS01055	COG0765	amino acid transport
OTBS_RS01180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OTBS_RS01185	COG0424	maF-like protein
OTBS_RS01190	COG0217	transcriptional regulatory protein
OTBS_RS01200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OTBS_RS01225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OTBS_RS01235	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OTBS_RS01240	COG0575	Belongs to the CDS family
OTBS_RS01250	COG0488	(ABC) transporter
OTBS_RS01255	COG0587	DNA-directed DNA polymerase activity
OTBS_RS01260	COG0525	valine-tRNA ligase activity
OTBS_RS01300	COG1565	acr, cog1565
OTBS_RS01300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OTBS_RS01305	COG1714	RDD family
OTBS_RS01310	COG3704	protein secretion by the type IV secretion system
OTBS_RS01310	COG1340	protein secretion by the type IV secretion system
OTBS_RS01340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OTBS_RS01400	COG0728	peptidoglycan biosynthetic process
OTBS_RS01450	COG3202	ADP transmembrane transporter activity
OTBS_RS01455	COG3202	ADP transmembrane transporter activity
OTBS_RS01465	COG0142	geranyltranstransferase activity
OTBS_RS01555	COG0163	prenyltransferase activity
OTBS_RS01560	COG1253	flavin adenine dinucleotide binding
OTBS_RS01565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OTBS_RS01575	COG0552	protein localization to endoplasmic reticulum
OTBS_RS01605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
OTBS_RS01610	COG1546	Belongs to the CinA family
OTBS_RS01610	COG1058	Belongs to the CinA family
OTBS_RS01615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OTBS_RS01630	COG0628	permease
OTBS_RS01635	COG0156	8-amino-7-oxononanoate synthase activity
OTBS_RS01645	COG0268	Binds directly to 16S ribosomal RNA
OTBS_RS01650	COG0203	ribosomal protein L17
OTBS_RS01655	COG0202	RNA polymerase activity
OTBS_RS01660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OTBS_RS01665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OTBS_RS01670	COG0563	adenylate kinase activity
OTBS_RS01675	COG0201	protein transport
OTBS_RS01680	COG0200	Binds to the 23S rRNA
OTBS_RS01685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OTBS_RS01690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OTBS_RS01695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OTBS_RS01700	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OTBS_RS01705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OTBS_RS01715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OTBS_RS01720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OTBS_RS01725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OTBS_RS01735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OTBS_RS01740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OTBS_RS01745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OTBS_RS01750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OTBS_RS01755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OTBS_RS01765	COG0088	Forms part of the polypeptide exit tunnel
OTBS_RS01770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OTBS_RS01780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OTBS_RS01795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OTBS_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
OTBS_RS01810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OTBS_RS01815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OTBS_RS01830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OTBS_RS01835	COG2867	negative regulation of translational initiation
OTBS_RS01840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OTBS_RS01845	COG0616	signal peptide processing
OTBS_RS01850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OTBS_RS01855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OTBS_RS01865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OTBS_RS01870	COG0335	large ribosomal subunit rRNA binding
OTBS_RS01875	COG0336	Belongs to the RNA methyltransferase TrmD family
OTBS_RS01900	COG4974	Belongs to the 'phage' integrase family
OTBS_RS01910	COG3346	SURF1 family
OTBS_RS01915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OTBS_RS01920	COG0742	ribosomal rna small subunit methyltransferase
OTBS_RS01925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OTBS_RS01960	COG0582	viral genome integration into host DNA
OTBS_RS02005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OTBS_RS02025	COG3118	belongs to the thioredoxin family
OTBS_RS02035	COG0750	zinc metalloprotease
OTBS_RS02040	COG1322	Protein conserved in bacteria
OTBS_RS02045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OTBS_RS02055	COG0776	regulation of translation
OTBS_RS02065	COG0803	Belongs to the bacterial solute-binding protein 9 family
OTBS_RS02070	COG0617	tRNA 3'-terminal CCA addition
OTBS_RS02075	COG1301	dicarboxylic acid transport
OTBS_RS02080	COG1074	ATP-dependent DNA helicase activity
OTBS_RS02090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OTBS_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OTBS_RS02100	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OTBS_RS02105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OTBS_RS02120	COG0545	Peptidyl-prolyl cis-trans isomerase
OTBS_RS02125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OTBS_RS02165	COG3485	protocatechuate 3,4-dioxygenase
OTBS_RS02170	COG0495	leucyl-tRNA aminoacylation
OTBS_RS02175	COG1466	dna polymerase III delta subunit
OTBS_RS02185	COG2239	Acts as a magnesium transporter
OTBS_RS02190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OTBS_RS02205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS02285	COG0582	viral genome integration into host DNA
OTBS_RS02290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OTBS_RS02300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OTBS_RS02305	COG1127	ABC transporter
OTBS_RS02310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OTBS_RS02315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OTBS_RS02325	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OTBS_RS02385	COG2807	transmembrane transport
OTBS_RS02530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OTBS_RS02540	COG3202	ADP transmembrane transporter activity
OTBS_RS02545	COG0359	binds to the 23S rRNA
OTBS_RS02550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OTBS_RS02555	COG0360	Binds together with S18 to 16S ribosomal RNA
OTBS_RS02560	COG0745	RESPONSE REGULATOR receiver
OTBS_RS02565	COG1132	(ABC) transporter
OTBS_RS02575	COG0544	peptidyl-prolyl cis-trans isomerase activity
OTBS_RS02585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OTBS_RS02590	COG0326	Molecular chaperone. Has ATPase activity
OTBS_RS02595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OTBS_RS02600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OTBS_RS02635	COG0228	four-way junction DNA binding
OTBS_RS02640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OTBS_RS02660	COG0018	arginyl-trna synthetase
OTBS_RS02665	COG0316	Belongs to the HesB IscA family
OTBS_RS02670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OTBS_RS02675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OTBS_RS02690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OTBS_RS02695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OTBS_RS02700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OTBS_RS02705	COG0756	dUTP diphosphatase activity
OTBS_RS02710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OTBS_RS02715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OTBS_RS02720	COG0285	dihydrofolate synthase activity
OTBS_RS02730	COG0653	protein targeting
OTBS_RS02740	COG0494	nUDIX hydrolase
OTBS_RS02765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OTBS_RS02780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OTBS_RS02785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OTBS_RS02805	COG0751	glycine-tRNA ligase activity
OTBS_RS02810	COG0009	L-threonylcarbamoyladenylate synthase
OTBS_RS02850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS02945	COG5464	transposase or invertase
OTBS_RS03065	COG0582	viral genome integration into host DNA
OTBS_RS03220	COG0698	ribose 5-phosphate isomerase
OTBS_RS03255	COG1132	(ABC) transporter
OTBS_RS03260	COG0528	UMP kinase activity
OTBS_RS03270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OTBS_RS03290	COG0275	rRNA processing
OTBS_RS03295	COG0484	heat shock protein binding
OTBS_RS03300	COG0443	Heat shock 70 kDa protein
OTBS_RS03310	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OTBS_RS03440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS03485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OTBS_RS03490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OTBS_RS03510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OTBS_RS03640	COG0356	it plays a direct role in the translocation of protons across the membrane
OTBS_RS03645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OTBS_RS03650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OTBS_RS03680	COG1674	ftsk spoiiie
OTBS_RS03690	COG0488	(ABC) transporter
OTBS_RS03710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OTBS_RS03725	COG0194	GDP metabolic process
OTBS_RS03795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS03825	COG1054	Belongs to the UPF0176 family
OTBS_RS03870	COG0666	response to abiotic stimulus
OTBS_RS03885	COG0784	Response regulator, receiver
OTBS_RS03885	COG2205	protein histidine kinase activity
OTBS_RS04000	COG0582	viral genome integration into host DNA
OTBS_RS04010	COG2205	protein histidine kinase activity
OTBS_RS04020	COG0473	3-isopropylmalate dehydrogenase activity
OTBS_RS04025	COG0181	hydroxymethylbilane synthase activity
OTBS_RS04070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OTBS_RS04085	COG1040	competence protein
OTBS_RS04090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OTBS_RS04095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OTBS_RS04100	COG3750	Belongs to the UPF0335 family
OTBS_RS04145	COG0666	response to abiotic stimulus
OTBS_RS04255	COG2205	protein histidine kinase activity
OTBS_RS04295	COG2202	Pas domain
OTBS_RS04295	COG2205	protein histidine kinase activity
OTBS_RS04330	COG0459	protein refolding
OTBS_RS04335	COG0736	holo-[acyl-carrier-protein] synthase activity
OTBS_RS04350	COG0670	Belongs to the BI1 family
OTBS_RS04365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OTBS_RS04370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OTBS_RS04455	COG0582	viral genome integration into host DNA
OTBS_RS04465	COG1214	PFAM Peptidase M22, glycoprotease
OTBS_RS04475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OTBS_RS04480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OTBS_RS04495	COG0126	phosphoglycerate kinase activity
OTBS_RS04500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OTBS_RS04545	COG0784	Response regulator, receiver
OTBS_RS04545	COG2205	protein histidine kinase activity
OTBS_RS04635	COG0305	Participates in initiation and elongation during chromosome replication
OTBS_RS04745	COG1132	(ABC) transporter
OTBS_RS04750	COG1965	Belongs to the frataxin family
OTBS_RS04790	COG1981	membrane
OTBS_RS04800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OTBS_RS04805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OTBS_RS04825	COG0445	tRNA wobble uridine modification
OTBS_RS04830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OTBS_RS04835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OTBS_RS04840	COG1587	Uroporphyrinogen-III synthase
OTBS_RS04845	COG1160	GTP binding
OTBS_RS04850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OTBS_RS04850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OTBS_RS04870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OTBS_RS04905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OTBS_RS04910	COG3202	ADP transmembrane transporter activity
OTBS_RS04920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OTBS_RS04925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OTBS_RS04930	COG0805	protein transport
OTBS_RS04935	COG0357	Ribosomal RNA small subunit methyltransferase G
OTBS_RS04940	COG1192	Involved in chromosome partitioning
OTBS_RS04945	COG1475	DNA binding
OTBS_RS04970	COG1722	exodeoxyribonuclease VII activity
OTBS_RS05095	COG2205	protein histidine kinase activity
OTBS_RS05095	COG0784	Response regulator, receiver
OTBS_RS05125	COG5464	transposase or invertase
OTBS_RS05200	COG4974	Belongs to the 'phage' integrase family
OTBS_RS05225	COG0633	Ferredoxin
OTBS_RS05230	COG0443	Heat shock 70 kDa protein
OTBS_RS05235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OTBS_RS05240	COG0316	Belongs to the HesB IscA family
OTBS_RS05245	COG0822	iron-sulfur transferase activity
OTBS_RS05255	COG1104	cysteine desulfurase activity
OTBS_RS05260	COG1959	2 iron, 2 sulfur cluster binding
OTBS_RS05265	COG2945	thiolester hydrolase activity
OTBS_RS05285	COG1215	transferase activity, transferring glycosyl groups
OTBS_RS05305	COG0582	viral genome integration into host DNA
OTBS_RS05315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OTBS_RS05320	COG0358	DNA primase activity
OTBS_RS05325	COG0758	DNA mediated transformation
OTBS_RS05330	COG0450	alkyl hydroperoxide reductase
OTBS_RS05355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OTBS_RS05365	COG0052	Belongs to the universal ribosomal protein uS2 family
OTBS_RS05370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OTBS_RS05375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OTBS_RS05375	COG0072	phenylalanine-tRNA ligase activity
OTBS_RS05385	COG0582	viral genome integration into host DNA
OTBS_RS05430	COG0666	response to abiotic stimulus
OTBS_RS05480	COG0784	Response regulator, receiver
OTBS_RS05480	COG2205	protein histidine kinase activity
OTBS_RS05530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS05545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS05565	COG0784	Response regulator, receiver
OTBS_RS05565	COG2205	protein histidine kinase activity
OTBS_RS05685	COG0582	viral genome integration into host DNA
OTBS_RS05690	COG1999	signal sequence binding
OTBS_RS05715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OTBS_RS05720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OTBS_RS05735	COG0811	peptide transport
OTBS_RS05740	COG0113	porphobilinogen synthase activity
OTBS_RS05755	COG0481	GTPase activity
OTBS_RS05795	COG0629	single-stranded DNA binding
OTBS_RS05820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OTBS_RS05880	COG0582	viral genome integration into host DNA
OTBS_RS05900	COG2204	response regulator
OTBS_RS05905	COG5000	phosphorelay sensor kinase activity
OTBS_RS05970	COG0784	Response regulator, receiver
OTBS_RS05970	COG2205	protein histidine kinase activity
OTBS_RS06070	COG0582	viral genome integration into host DNA
OTBS_RS06110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OTBS_RS06115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OTBS_RS06135	COG0280	phosphate acetyltransferase
OTBS_RS06135	COG0281	malic enzyme
OTBS_RS06275	COG0582	viral genome integration into host DNA
OTBS_RS06330	COG0740	serine-type endopeptidase activity
OTBS_RS06355	COG0024	Methionine aminopeptidase
OTBS_RS06405	COG0154	amidase activity
OTBS_RS06410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OTBS_RS06425	COG0666	response to abiotic stimulus
OTBS_RS06455	COG0784	Response regulator, receiver
OTBS_RS06455	COG2205	protein histidine kinase activity
OTBS_RS06490	COG4133	protoheme IX ABC transporter activity
OTBS_RS06510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OTBS_RS06530	COG0531	amino acid
OTBS_RS06535	COG1573	uracil-dna glycosylase
OTBS_RS06545	COG0582	viral genome integration into host DNA
OTBS_RS06565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OTBS_RS06580	COG0531	amino acid
OTBS_RS06590	COG0187	DNA topoisomerase II activity
OTBS_RS06595	COG1011	Hydrolase
OTBS_RS06625	COG0651	ATP synthesis coupled electron transport
OTBS_RS06630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OTBS_RS06655	COG0338	D12 class N6 adenine-specific DNA methyltransferase
OTBS_RS06670	COG4974	Belongs to the 'phage' integrase family
OTBS_RS06735	COG5464	transposase or invertase
OTBS_RS06765	COG0784	Response regulator, receiver
OTBS_RS06765	COG2205	protein histidine kinase activity
OTBS_RS06815	COG4974	Belongs to the 'phage' integrase family
OTBS_RS06915	COG1138	Cytochrome C-type biogenesis protein
OTBS_RS06920	COG4536	flavin adenine dinucleotide binding
OTBS_RS06930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OTBS_RS06940	COG0508	dehydrogenase complex catalyzes the overall conversion of
OTBS_RS06950	COG0477	Major facilitator Superfamily
OTBS_RS06960	COG1845	cytochrome c oxidase, subunit III
OTBS_RS06965	COG2255	four-way junction helicase activity
OTBS_RS06970	COG0632	four-way junction helicase activity
OTBS_RS06985	COG2814	Major facilitator Superfamily
OTBS_RS07000	COG2205	protein histidine kinase activity
OTBS_RS07010	COG0582	viral genome integration into host DNA
OTBS_RS07075	COG5464	transposase or invertase
OTBS_RS07120	COG0321	lipoyl(octanoyl) transferase activity
OTBS_RS07125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OTBS_RS07135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OTBS_RS07150	COG0527	aspartate kinase activity
OTBS_RS07165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OTBS_RS07205	COG1530	ribonuclease E activity
OTBS_RS07235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OTBS_RS07240	COG2226	methyltransferase
OTBS_RS07245	COG0779	Required for maturation of 30S ribosomal subunits
OTBS_RS07250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OTBS_RS07250	COG0195	Participates in both transcription termination and antitermination
OTBS_RS07255	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OTBS_RS07305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OTBS_RS07310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
OTBS_RS07325	COG0328	RNA-DNA hybrid ribonuclease activity
OTBS_RS07340	COG0124	histidyl-tRNA synthetase
OTBS_RS07395	COG0666	response to abiotic stimulus
OTBS_RS07435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OTBS_RS07440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OTBS_RS07455	COG1295	ribonuclease BN
OTBS_RS07470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OTBS_RS07475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OTBS_RS07480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OTBS_RS07485	COG0649	NAD binding
OTBS_RS07495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OTBS_RS07505	COG3202	ADP transmembrane transporter activity
OTBS_RS07520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OTBS_RS07530	COG1872	DUF167
OTBS_RS07535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OTBS_RS07540	COG2890	protein-(glutamine-N5) methyltransferase activity
OTBS_RS07540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OTBS_RS07545	COG0101	tRNA pseudouridine synthase activity
OTBS_RS07550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OTBS_RS07600	COG0784	Response regulator, receiver
OTBS_RS07600	COG2205	protein histidine kinase activity
OTBS_RS07615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS07705	COG0582	viral genome integration into host DNA
OTBS_RS07740	COG4695	Portal protein
OTBS_RS07785	COG4974	Belongs to the 'phage' integrase family
OTBS_RS07790	COG0582	viral genome integration into host DNA
OTBS_RS07795	COG2009	succinate dehydrogenase
OTBS_RS07805	COG1053	succinate dehydrogenase
OTBS_RS07810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OTBS_RS07825	COG0571	ribonuclease III activity
OTBS_RS07845	COG0400	carboxylic ester hydrolase activity
OTBS_RS07850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OTBS_RS07855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OTBS_RS07860	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OTBS_RS07875	COG0590	tRNA wobble adenosine to inosine editing
OTBS_RS07880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OTBS_RS07920	COG0582	viral genome integration into host DNA
OTBS_RS07985	COG5464	transposase or invertase
OTBS_RS08020	COG2205	protein histidine kinase activity
OTBS_RS08020	COG0784	Response regulator, receiver
OTBS_RS08070	COG1862	Preprotein translocase
OTBS_RS08075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OTBS_RS08090	COG0436	Aminotransferase
OTBS_RS08100	COG2853	Lipoprotein
OTBS_RS08110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OTBS_RS08120	COG1381	Involved in DNA repair and RecF pathway recombination
OTBS_RS08145	COG2003	Belongs to the UPF0758 family
OTBS_RS08150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OTBS_RS08155	COG0049	tRNA binding
OTBS_RS08160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OTBS_RS08180	COG1278	Cold shock
OTBS_RS08210	COG0537	adenosine 5'-monophosphoramidase activity
OTBS_RS08215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OTBS_RS08220	COG0109	protoheme IX farnesyltransferase activity
OTBS_RS08235	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OTBS_RS08240	COG0193	aminoacyl-tRNA hydrolase activity
OTBS_RS08245	COG0012	GTP binding
OTBS_RS08250	COG0708	Exodeoxyribonuclease III
OTBS_RS08270	COG3474	cytochrome
OTBS_RS08275	COG0330	HflC and HflK could
OTBS_RS08340	COG0489	protein tyrosine kinase activity
OTBS_RS08350	COG0330	HflC and HflK could
OTBS_RS08355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OTBS_RS08365	COG2885	chlorophyll binding
OTBS_RS08375	COG0492	ferredoxin-NADP+ reductase activity
OTBS_RS08380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OTBS_RS08385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OTBS_RS08390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OTBS_RS08395	COG0039	L-malate dehydrogenase activity
OTBS_RS08400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OTBS_RS08410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OTBS_RS08415	COG0242	peptide deformylase activity
OTBS_RS08500	COG0105	UTP biosynthetic process
OTBS_RS08520	COG0305	Participates in initiation and elongation during chromosome replication
OTBS_RS08525	COG4974	Belongs to the 'phage' integrase family
OTBS_RS08620	COG1612	heme a metabolic process
OTBS_RS08635	COG2814	Major facilitator Superfamily
OTBS_RS08645	COG0582	viral genome integration into host DNA
OTBS_RS08695	COG4974	Belongs to the 'phage' integrase family
OTBS_RS08715	COG1121	(ABC) transporter
OTBS_RS08720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OTBS_RS08725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OTBS_RS08740	COG1570	exodeoxyribonuclease VII activity
OTBS_RS08745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OTBS_RS08760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OTBS_RS08800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OTBS_RS08830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS08870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OTBS_RS08875	COG3264	Mechanosensitive ion channel
OTBS_RS08875	COG1196	nuclear chromosome segregation
OTBS_RS08880	COG0084	hydrolase, TatD family'
OTBS_RS08890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OTBS_RS08900	COG3451	type IV secretory pathway VirB4
OTBS_RS08905	COG3704	protein secretion by the type IV secretion system
OTBS_RS08910	COG3704	protein secretion by the type IV secretion system
OTBS_RS08915	COG3704	protein secretion by the type IV secretion system
OTBS_RS08920	COG3704	protein secretion by the type IV secretion system
OTBS_RS08930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OTBS_RS08935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OTBS_RS08940	COG0215	cysteine-tRNA ligase activity
OTBS_RS08950	COG0210	DNA helicase
OTBS_RS08975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OTBS_RS09010	COG2205	protein histidine kinase activity
OTBS_RS09010	COG0784	Response regulator, receiver
OTBS_RS09065	COG0582	viral genome integration into host DNA
OTBS_RS09110	COG0666	response to abiotic stimulus
OTBS_RS09150	COG5464	transposase or invertase
OTBS_RS09180	COG2205	protein histidine kinase activity
OTBS_RS09180	COG0784	Response regulator, receiver
OTBS_RS09255	COG0582	viral genome integration into host DNA
OTBS_RS09360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OTBS_RS09370	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OTBS_RS09440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS09480	COG5464	transposase or invertase
OTBS_RS09575	COG0582	viral genome integration into host DNA
OTBS_RS09595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS09610	COG0482	sulfurtransferase activity
OTBS_RS09665	COG2205	protein histidine kinase activity
OTBS_RS09665	COG0784	Response regulator, receiver
OTBS_RS09745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OTBS_RS09770	COG0305	Participates in initiation and elongation during chromosome replication
OTBS_RS09870	COG0564	pseudouridine synthase activity
OTBS_RS09880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
OTBS_RS09890	COG4974	Belongs to the 'phage' integrase family
OTBS_RS09895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OTBS_RS09920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OTBS_RS09925	COG0717	Belongs to the dCTP deaminase family
OTBS_RS09930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
OTBS_RS09935	COG0233	cytoplasmic translational termination
OTBS_RS09940	COG1034	ATP synthesis coupled electron transport
OTBS_RS09945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
OTBS_RS09950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OTBS_RS09955	COG0839	Belongs to the complex I subunit 6 family
OTBS_RS09960	COG0713	ATP synthesis coupled electron transport
OTBS_RS09965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OTBS_RS09970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
OTBS_RS09980	COG0037	tRNA processing
OTBS_RS09985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OTBS_RS09990	COG2094	Belongs to the DNA glycosylase MPG family
OTBS_RS10000	COG0772	Belongs to the SEDS family
OTBS_RS10010	COG0768	penicillin binding
OTBS_RS10015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OTBS_RS10120	COG0594	ribonuclease P activity
OTBS_RS10165	COG4974	Belongs to the 'phage' integrase family
OTBS_RS10190	COG4974	Belongs to the 'phage' integrase family
OTBS_RS10295	COG4974	Belongs to the 'phage' integrase family
OTBS_RS10340	COG4974	Belongs to the 'phage' integrase family
OTBS_RS10455	COG0508	dehydrogenase complex catalyzes the overall conversion of
OTBS_RS10460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OTBS_RS10465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OTBS_RS10470	COG4974	Belongs to the 'phage' integrase family
OTBS_RS10665	COG0305	Participates in initiation and elongation during chromosome replication
OTBS_RS10735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta