locus-tag	class	description
BRW84_RS00010	COG0051	transcription antitermination factor activity, RNA binding
BRW84_RS00020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BRW84_RS00025	COG0049	tRNA binding
BRW84_RS00030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BRW84_RS00035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BRW84_RS00040	COG0085	RNA polymerase activity
BRW84_RS00045	COG0222	ribosome binding
BRW84_RS00050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BRW84_RS00055	COG0081	regulation of translation
BRW84_RS00060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BRW84_RS00125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BRW84_RS00130	COG0459	protein refolding
BRW84_RS00135	COG1846	Transcriptional regulator
BRW84_RS00145	COG0735	belongs to the Fur family
BRW84_RS00150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRW84_RS00155	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BRW84_RS00160	COG0495	leucyl-tRNA aminoacylation
BRW84_RS00170	COG1466	dna polymerase III delta subunit
BRW84_RS00175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BRW84_RS00195	COG0312	modulator of DNA gyrase
BRW84_RS00200	COG3028	Belongs to the UPF0307 family
BRW84_RS00205	COG0521	Mo-molybdopterin cofactor biosynthetic process
BRW84_RS00210	COG0400	carboxylic ester hydrolase activity
BRW84_RS00215	COG4681	YaeQ
BRW84_RS00220	COG0668	transmembrane transport
BRW84_RS00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BRW84_RS00235	COG0601	transmembrane transport
BRW84_RS00250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRW84_RS00255	COG0494	nUDIX hydrolase
BRW84_RS00260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BRW84_RS00275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BRW84_RS00285	COG2226	methyltransferase
BRW84_RS00295	COG1238	metal cluster binding
BRW84_RS00300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BRW84_RS00315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BRW84_RS00320	COG1660	Displays ATPase and GTPase activities
BRW84_RS00325	COG1194	a g-specific adenine glycosylase
BRW84_RS00335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BRW84_RS00345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRW84_RS00350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BRW84_RS00360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BRW84_RS00365	COG0193	aminoacyl-tRNA hydrolase activity
BRW84_RS00375	COG2900	Belongs to the SlyX family
BRW84_RS00380	COG0210	DNA helicase
BRW84_RS00385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BRW84_RS00390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BRW84_RS00400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BRW84_RS00405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BRW84_RS00410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BRW84_RS00450	COG1346	cytolysis
BRW84_RS00455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRW84_RS00465	COG0617	tRNA 3'-terminal CCA addition
BRW84_RS00475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BRW84_RS00490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BRW84_RS00495	COG0792	nuclease activity
BRW84_RS00515	COG3158	transport of potassium into the cell
BRW84_RS00520	COG0488	(ABC) transporter
BRW84_RS00525	COG1127	ABC transporter
BRW84_RS00530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRW84_RS00535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BRW84_RS00555	COG1131	(ABC) transporter
BRW84_RS00560	COG0842	Transport permease protein
BRW84_RS00565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BRW84_RS00570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BRW84_RS00575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BRW84_RS00580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BRW84_RS00585	COG0131	Imidazoleglycerol-phosphate dehydratase
BRW84_RS00595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BRW84_RS00600	COG0107	imidazoleglycerol-phosphate synthase activity
BRW84_RS00605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BRW84_RS00610	COG0140	phosphoribosyl-ATP diphosphatase activity
BRW84_RS00620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW84_RS00625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BRW84_RS00630	COG0625	glutathione transferase activity
BRW84_RS00635	COG2969	positive regulation of protein catabolic process
BRW84_RS00645	COG0427	acetyl-CoA hydrolase
BRW84_RS00660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BRW84_RS00665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BRW84_RS00670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BRW84_RS00675	COG2205	protein histidine kinase activity
BRW84_RS00680	COG0745	RESPONSE REGULATOR receiver
BRW84_RS00685	COG0733	neurotransmitter:sodium symporter activity
BRW84_RS00690	COG0673	inositol 2-dehydrogenase activity
BRW84_RS00705	COG0163	prenyltransferase activity
BRW84_RS00710	COG2183	response to ionizing radiation
BRW84_RS00715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BRW84_RS00720	COG0783	Belongs to the Dps family
BRW84_RS00725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRW84_RS00730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRW84_RS00735	COG0762	integral membrane protein
BRW84_RS00740	COG1872	DUF167
BRW84_RS00750	COG0519	Catalyzes the synthesis of GMP from XMP
BRW84_RS00760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BRW84_RS00775	COG4575	ribosome binding
BRW84_RS00780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BRW84_RS00795	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BRW84_RS00800	COG0343	queuine tRNA-ribosyltransferase activity
BRW84_RS00805	COG1862	Preprotein translocase
BRW84_RS00815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BRW84_RS00835	COG0018	arginyl-trna synthetase
BRW84_RS00845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRW84_RS00855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BRW84_RS00860	COG0321	lipoyl(octanoyl) transferase activity
BRW84_RS00865	COG2921	Belongs to the UPF0250 family
BRW84_RS00875	COG2945	thiolester hydrolase activity
BRW84_RS00890	COG1127	ABC transporter
BRW84_RS00895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BRW84_RS00900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BRW84_RS00910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRW84_RS00920	COG0356	it plays a direct role in the translocation of protons across the membrane
BRW84_RS00930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BRW84_RS00940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BRW84_RS00945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BRW84_RS00950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BRW84_RS00955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BRW84_RS00960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRW84_RS00970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BRW84_RS00980	COG1611	Belongs to the LOG family
BRW84_RS00985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRW84_RS00985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BRW84_RS00995	COG1722	exodeoxyribonuclease VII activity
BRW84_RS01000	COG0142	geranyltranstransferase activity
BRW84_RS01005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BRW84_RS01010	COG1469	GTP cyclohydrolase I activity
BRW84_RS01015	COG2096	Adenosyltransferase
BRW84_RS01020	COG0418	dihydroorotase activity
BRW84_RS01030	COG0445	tRNA wobble uridine modification
BRW84_RS01035	COG0357	Ribosomal RNA small subunit methyltransferase G
BRW84_RS01040	COG1192	Involved in chromosome partitioning
BRW84_RS01055	COG0006	proline dipeptidase activity
BRW84_RS01075	COG0628	permease
BRW84_RS01085	COG0592	DNA-directed DNA polymerase activity
BRW84_RS01090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRW84_RS01100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BRW84_RS01105	COG0594	ribonuclease P activity
BRW84_RS01110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BRW84_RS01115	COG0706	membrane insertase activity
BRW84_RS01125	COG1309	transcriptional regulator
BRW84_RS01130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BRW84_RS01140	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BRW84_RS01145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BRW84_RS01155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BRW84_RS01160	COG0134	indole-3-glycerol-phosphate synthase activity
BRW84_RS01180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRW84_RS01195	COG0582	viral genome integration into host DNA
BRW84_RS01225	COG2314	TM2 domain
BRW84_RS01255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BRW84_RS01260	COG1151	hydroxylamine reductase activity
BRW84_RS01300	COG1764	response to oxidative stress
BRW84_RS01320	COG1942	4-Oxalocrotonate Tautomerase
BRW84_RS01325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BRW84_RS01330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRW84_RS01330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BRW84_RS01375	COG1215	transferase activity, transferring glycosyl groups
BRW84_RS01390	COG0535	radical SAM domain protein
BRW84_RS01395	COG1253	flavin adenine dinucleotide binding
BRW84_RS01400	COG0142	geranyltranstransferase activity
BRW84_RS01435	COG3960	tartronate-semialdehyde synthase activity
BRW84_RS01440	COG3622	Belongs to the hyi family
BRW84_RS01445	COG2084	Dehydrogenase
BRW84_RS01455	COG0469	pyruvate kinase activity
BRW84_RS01475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BRW84_RS01480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRW84_RS01485	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BRW84_RS01490	COG1950	PFAM Membrane protein of
BRW84_RS01495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BRW84_RS01500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRW84_RS01515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BRW84_RS01520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRW84_RS01530	COG2951	lytic endotransglycosylase activity
BRW84_RS01555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BRW84_RS01560	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BRW84_RS01565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BRW84_RS01585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BRW84_RS01590	COG0037	tRNA processing
BRW84_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
BRW84_RS01620	COG0606	chelatase, subunit chli
BRW84_RS01635	COG0189	ligase activity
BRW84_RS01645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BRW84_RS01650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BRW84_RS01655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRW84_RS01660	COG2813	Specifically methylates the guanine in position
BRW84_RS01660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BRW84_RS01665	COG2814	Major facilitator Superfamily
BRW84_RS01670	COG0133	tryptophan synthase activity
BRW84_RS01675	COG0708	Exodeoxyribonuclease III
BRW84_RS01680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BRW84_RS01685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BRW84_RS01690	COG0793	Belongs to the peptidase S41A family
BRW84_RS01715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BRW84_RS01720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BRW84_RS01725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BRW84_RS01735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRW84_RS01740	COG0312	modulator of DNA gyrase
BRW84_RS01745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BRW84_RS01755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BRW84_RS01760	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BRW84_RS01765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BRW84_RS01770	COG0235	Class ii aldolase
BRW84_RS01775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BRW84_RS01780	COG0137	argininosuccinate synthase activity
BRW84_RS01785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BRW84_RS01790	COG1162	GTPase activity
BRW84_RS01795	COG0501	Belongs to the peptidase M48B family
BRW84_RS01800	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BRW84_RS01815	COG3568	Endonuclease Exonuclease Phosphatase
BRW84_RS01830	COG2001	Belongs to the MraZ family
BRW84_RS01835	COG0275	rRNA processing
BRW84_RS01850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BRW84_RS01855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BRW84_RS01860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BRW84_RS01865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BRW84_RS01875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BRW84_RS01880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRW84_RS01885	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRW84_RS01890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BRW84_RS01905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BRW84_RS01915	COG0653	protein targeting
BRW84_RS01920	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BRW84_RS01935	COG0525	valine-tRNA ligase activity
BRW84_RS01940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BRW84_RS01950	COG2022	thiamine diphosphate biosynthetic process
BRW84_RS01955	COG0351	phosphomethylpyrimidine kinase
BRW84_RS01960	COG0352	thiamine-phosphate diphosphorylase activity
BRW84_RS01965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BRW84_RS01970	COG0210	DNA helicase
BRW84_RS01975	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BRW84_RS01980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BRW84_RS01990	COG0776	regulation of translation
BRW84_RS02000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BRW84_RS02020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRW84_RS02025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BRW84_RS02030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BRW84_RS02040	COG3012	SEC-C Motif Domain Protein
BRW84_RS02045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BRW84_RS02060	COG0339	signal peptide processing
BRW84_RS02065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BRW84_RS02070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BRW84_RS02075	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRW84_RS02080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW84_RS02090	COG1278	Cold shock
BRW84_RS02100	COG0542	response to heat
BRW84_RS02110	COG0656	L-ascorbic acid biosynthetic process
BRW84_RS02120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BRW84_RS02125	COG0242	peptide deformylase activity
BRW84_RS02130	COG0758	DNA mediated transformation
BRW84_RS02140	COG0667	Aldo Keto reductase
BRW84_RS02145	COG2204	response regulator
BRW84_RS02145	COG2204	response regulator
BRW84_RS02150	COG5000	phosphorelay sensor kinase activity
BRW84_RS02170	COG0546	phosphoglycolate phosphatase activity
BRW84_RS02175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BRW84_RS02180	COG2967	ApaG domain
BRW84_RS02185	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BRW84_RS02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BRW84_RS02205	COG0741	lytic transglycosylase activity
BRW84_RS02210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BRW84_RS02220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BRW84_RS02225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BRW84_RS02230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BRW84_RS02240	COG0268	Binds directly to 16S ribosomal RNA
BRW84_RS02245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BRW84_RS02255	COG2264	protein methyltransferase activity
BRW84_RS02260	COG0439	Biotin carboxylase
BRW84_RS02265	COG0511	ligase activity, forming carbon-carbon bonds
BRW84_RS02270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BRW84_RS02280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BRW84_RS02285	COG3150	esterase
BRW84_RS02290	COG0557	exoribonuclease II activity
BRW84_RS02300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BRW84_RS02305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BRW84_RS02310	COG0598	Magnesium transport protein CorA
BRW84_RS02330	COG0045	succinate-CoA ligase (ADP-forming) activity
BRW84_RS02335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BRW84_RS02340	COG1546	Belongs to the CinA family
BRW84_RS02345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BRW84_RS02360	COG0305	Participates in initiation and elongation during chromosome replication
BRW84_RS02365	COG1392	Phosphate transport regulator
BRW84_RS02370	COG0306	phosphate transporter
BRW84_RS02380	COG0670	Belongs to the BI1 family
BRW84_RS02390	COG0583	DNA-binding transcription factor activity
BRW84_RS02395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BRW84_RS02400	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BRW84_RS02405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRW84_RS02410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BRW84_RS02415	COG3178	'Phosphotransferase
BRW84_RS02420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BRW84_RS02425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BRW84_RS02440	COG0482	sulfurtransferase activity
BRW84_RS02445	COG0625	glutathione transferase activity
BRW84_RS02455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BRW84_RS02460	COG2084	Dehydrogenase
BRW84_RS02465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BRW84_RS02470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRW84_RS02475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BRW84_RS02480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BRW84_RS02490	COG0442	prolyl-tRNA aminoacylation
BRW84_RS02495	COG0494	nUDIX hydrolase
BRW84_RS02505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BRW84_RS02510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BRW84_RS02515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BRW84_RS02520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BRW84_RS02525	COG0728	peptidoglycan biosynthetic process
BRW84_RS02530	COG0488	(ABC) transporter
BRW84_RS02540	COG0671	phosphoesterase, PA-phosphatase related
BRW84_RS02550	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRW84_RS02555	COG0288	reversible hydration of carbon dioxide
BRW84_RS02560	COG3585	molybdate ion transport
BRW84_RS02565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BRW84_RS02575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BRW84_RS02580	COG0617	tRNA 3'-terminal CCA addition
BRW84_RS02590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BRW84_RS02595	COG0628	permease
BRW84_RS02600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BRW84_RS02625	COG0860	N-Acetylmuramoyl-L-alanine amidase
BRW84_RS02630	COG0802	atpase or kinase
BRW84_RS02645	COG4974	Belongs to the 'phage' integrase family
BRW84_RS02655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BRW84_RS02660	COG2197	response regulator
BRW84_RS02665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRW84_RS02670	COG0501	Belongs to the peptidase M48B family
BRW84_RS02680	COG0667	Aldo Keto reductase
BRW84_RS02685	COG0167	dihydroorotate dehydrogenase activity
BRW84_RS02690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BRW84_RS02715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BRW84_RS02725	COG0784	Response regulator, receiver
BRW84_RS02725	COG5002	protein histidine kinase activity
BRW84_RS02725	COG2205	protein histidine kinase activity
BRW84_RS02735	COG5001	Diguanylate cyclase
BRW84_RS02740	COG3706	GGDEF domain
BRW84_RS02745	COG1584	GPR1 FUN34 yaaH family protein
BRW84_RS02770	COG1716	ATPase activity
BRW84_RS02770	COG5001	Diguanylate cyclase
BRW84_RS02785	COG0679	Auxin Efflux Carrier
BRW84_RS02800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BRW84_RS02815	COG0228	four-way junction DNA binding
BRW84_RS02820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BRW84_RS02825	COG0336	Belongs to the RNA methyltransferase TrmD family
BRW84_RS02830	COG0335	large ribosomal subunit rRNA binding
BRW84_RS02840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BRW84_RS02845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRW84_RS02865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BRW84_RS02880	COG0494	nUDIX hydrolase
BRW84_RS02885	COG2255	four-way junction helicase activity
BRW84_RS02890	COG0632	four-way junction helicase activity
BRW84_RS02895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BRW84_RS02900	COG0138	bifunctional purine biosynthesis protein purh
BRW84_RS02915	COG0588	phosphoglycerate mutase activity
BRW84_RS02920	COG1881	PFAM PEBP family protein
BRW84_RS02925	COG1490	D-aminoacyl-tRNA deacylase activity
BRW84_RS02940	COG3437	response regulator, receiver
BRW84_RS02945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BRW84_RS02950	COG0739	heme binding
BRW84_RS02960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BRW84_RS02965	COG1758	RNA polymerase activity
BRW84_RS02970	COG0194	GDP metabolic process
BRW84_RS02980	COG0564	pseudouridine synthase activity
BRW84_RS02990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRW84_RS02995	COG0626	cystathionine gamma-synthase activity
BRW84_RS03010	COG0405	Gamma-glutamyltransferase
BRW84_RS03015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS03020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BRW84_RS03025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BRW84_RS03030	COG3706	GGDEF domain
BRW84_RS03055	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BRW84_RS03060	COG0494	nUDIX hydrolase
BRW84_RS03065	COG1278	Cold shock
BRW84_RS03070	COG2814	Major facilitator Superfamily
BRW84_RS03090	COG1523	belongs to the glycosyl hydrolase 13 family
BRW84_RS03095	COG0033	Phosphoglucomutase
BRW84_RS03110	COG0058	SHG alpha-glucan phosphorylase activity
BRW84_RS03115	COG0500	methyltransferase
BRW84_RS03140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BRW84_RS03195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BRW84_RS03200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BRW84_RS03205	COG1137	ATPase activity
BRW84_RS03210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BRW84_RS03220	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BRW84_RS03240	COG0629	single-stranded DNA binding
BRW84_RS03260	COG0248	Ppx GppA phosphatase
BRW84_RS03275	COG0071	Belongs to the small heat shock protein (HSP20) family
BRW84_RS03285	COG0069	glutamate synthase activity
BRW84_RS03285	COG0070	glutamate synthase
BRW84_RS03285	COG0067	glutamate synthase
BRW84_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BRW84_RS03300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BRW84_RS03305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BRW84_RS03315	COG1047	Peptidyl-prolyl cis-trans
BRW84_RS03320	COG0149	triose-phosphate isomerase activity
BRW84_RS03325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BRW84_RS03345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW84_RS03350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW84_RS03355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BRW84_RS03360	COG0649	NAD binding
BRW84_RS03365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BRW84_RS03375	COG1034	ATP synthesis coupled electron transport
BRW84_RS03380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BRW84_RS03395	COG0713	ATP synthesis coupled electron transport
BRW84_RS03410	COG1007	ATP synthesis coupled electron transport
BRW84_RS03415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BRW84_RS03425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BRW84_RS03435	COG0066	3-isopropylmalate dehydratase activity
BRW84_RS03440	COG0473	3-isopropylmalate dehydrogenase activity
BRW84_RS03445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BRW84_RS03455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BRW84_RS03460	COG1121	(ABC) transporter
BRW84_RS03465	COG3443	Belongs to the bacterial solute-binding protein 9 family
BRW84_RS03465	COG0803	Belongs to the bacterial solute-binding protein 9 family
BRW84_RS03485	COG0101	tRNA pseudouridine synthase activity
BRW84_RS03490	COG0135	phosphoribosylanthranilate isomerase activity
BRW84_RS03495	COG0133	tryptophan synthase activity
BRW84_RS03505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BRW84_RS03510	COG0285	dihydrofolate synthase activity
BRW84_RS03535	COG1032	radical SAM domain protein
BRW84_RS03540	COG0481	GTPase activity
BRW84_RS03550	COG0571	ribonuclease III activity
BRW84_RS03555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BRW84_RS03565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BRW84_RS03570	COG0736	holo-[acyl-carrier-protein] synthase activity
BRW84_RS03580	COG0322	excinuclease ABC activity
BRW84_RS03610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRW84_RS03625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BRW84_RS03630	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRW84_RS03635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BRW84_RS03670	COG1902	pentaerythritol trinitrate reductase activity
BRW84_RS03695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BRW84_RS03700	COG0154	amidase activity
BRW84_RS03705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BRW84_RS03710	COG1077	Cell shape determining protein MreB Mrl
BRW84_RS03715	COG1792	Involved in formation and maintenance of cell shape
BRW84_RS03725	COG0768	penicillin binding
BRW84_RS03730	COG0772	Belongs to the SEDS family
BRW84_RS03745	COG0523	cobalamin synthesis protein
BRW84_RS03750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS03755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS03760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BRW84_RS03770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BRW84_RS03785	COG0540	Belongs to the ATCase OTCase family
BRW84_RS03790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BRW84_RS03795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BRW84_RS03800	COG1678	Uncharacterized ACR, COG1678
BRW84_RS03805	COG0717	Belongs to the dCTP deaminase family
BRW84_RS03815	COG0824	Thioesterase
BRW84_RS03835	COG0823	Involved in the tonB-independent uptake of proteins
BRW84_RS03850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BRW84_RS03875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BRW84_RS03880	COG4206	TonB-dependent receptor
BRW84_RS03885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BRW84_RS03900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BRW84_RS03905	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BRW84_RS03920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW84_RS03920	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW84_RS03925	COG0489	protein tyrosine kinase activity
BRW84_RS03940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRW84_RS03965	COG0315	cyclic pyranopterin monophosphate synthase activity
BRW84_RS03970	COG4783	chaperone-mediated protein folding
BRW84_RS03975	COG0513	Belongs to the DEAD box helicase family
BRW84_RS03985	COG1388	LysM domain
BRW84_RS03985	COG0741	lytic transglycosylase activity
BRW84_RS03990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BRW84_RS03995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BRW84_RS03995	COG4651	solute:proton antiporter activity
BRW84_RS04045	COG0346	lactoylglutathione lyase activity
BRW84_RS04060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BRW84_RS04065	COG0751	glycine-tRNA ligase activity
BRW84_RS04070	COG0752	glycyl-tRNA synthetase alpha subunit
BRW84_RS04075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BRW84_RS04080	COG0308	aminopeptidase N
BRW84_RS04090	COG2916	Histone family protein nucleoid-structuring protein H-NS
BRW84_RS04100	COG3022	response to hydroperoxide
BRW84_RS04140	COG0779	Required for maturation of 30S ribosomal subunits
BRW84_RS04145	COG0195	Participates in both transcription termination and antitermination
BRW84_RS04150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BRW84_RS04155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BRW84_RS04165	COG1217	gtp-binding protein TYPA
BRW84_RS04185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BRW84_RS04205	COG2226	methyltransferase
BRW84_RS04225	COG3300	MHYT domain
BRW84_RS04225	COG5001	Diguanylate cyclase
BRW84_RS04235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BRW84_RS04240	COG0328	RNA-DNA hybrid ribonuclease activity
BRW84_RS04250	COG0488	(ABC) transporter
BRW84_RS04255	COG2890	protein-(glutamine-N5) methyltransferase activity
BRW84_RS04260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BRW84_RS04265	COG2171	N-acyltransferase activity
BRW84_RS04270	COG0436	Aminotransferase
BRW84_RS04290	COG2205	protein histidine kinase activity
BRW84_RS04290	COG0784	Response regulator, receiver
BRW84_RS04300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BRW84_RS04310	COG0126	phosphoglycerate kinase activity
BRW84_RS04320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BRW84_RS04325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BRW84_RS04330	COG0009	L-threonylcarbamoyladenylate synthase
BRW84_RS04345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BRW84_RS04350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BRW84_RS04355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BRW84_RS04360	COG0534	Mate efflux family protein
BRW84_RS04370	COG0254	rRNA binding
BRW84_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
BRW84_RS04390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BRW84_RS04395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BRW84_RS04400	COG0425	Belongs to the sulfur carrier protein TusA family
BRW84_RS04415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRW84_RS04420	COG2226	methyltransferase
BRW84_RS04440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BRW84_RS04455	COG0613	PHP domain protein
BRW84_RS04460	COG0501	Belongs to the peptidase M48B family
BRW84_RS04465	COG0009	L-threonylcarbamoyladenylate synthase
BRW84_RS04470	COG1994	Peptidase M50
BRW84_RS04475	COG0180	Tryptophanyl-tRNA synthetase
BRW84_RS04480	COG0505	Belongs to the CarA family
BRW84_RS04485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BRW84_RS04500	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BRW84_RS04505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BRW84_RS04510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BRW84_RS04515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BRW84_RS04530	COG3706	GGDEF domain
BRW84_RS04530	COG2203	Gaf domain
BRW84_RS04530	COG5001	Diguanylate cyclase
BRW84_RS04530	COG4251	negative regulation of phosphorylation
BRW84_RS04560	COG0531	amino acid
BRW84_RS04565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BRW84_RS04585	COG0431	NADPH-dependent FMN reductase
BRW84_RS04590	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BRW84_RS04595	COG0842	Transport permease protein
BRW84_RS04600	COG1129	ABC transporter
BRW84_RS04600	COG0842	Transport permease protein
BRW84_RS04605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW84_RS04610	COG0826	peptidase U32
BRW84_RS04615	COG0826	peptidase U32
BRW84_RS04620	COG3154	lipid carrier protein
BRW84_RS04625	COG2095	MarC family integral membrane protein
BRW84_RS04650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BRW84_RS04655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRW84_RS04660	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BRW84_RS04665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BRW84_RS04670	COG1674	ftsk spoiiie
BRW84_RS04675	COG0492	ferredoxin-NADP+ reductase activity
BRW84_RS04680	COG1193	negative regulation of DNA recombination
BRW84_RS04695	COG0347	Belongs to the P(II) protein family
BRW84_RS04700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BRW84_RS04700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BRW84_RS04710	COG0303	'Molybdopterin
BRW84_RS04715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BRW84_RS04725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRW84_RS04730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRW84_RS04740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BRW84_RS04750	COG0519	Catalyzes the synthesis of GMP from XMP
BRW84_RS04750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BRW84_RS04760	COG5001	Diguanylate cyclase
BRW84_RS04760	COG3300	MHYT domain
BRW84_RS04765	COG0602	queuosine metabolic process
BRW84_RS04770	COG0720	synthase
BRW84_RS04780	COG1619	proteins homologs of microcin C7 resistance protein MccF
BRW84_RS04785	COG0488	(ABC) transporter
BRW84_RS04790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BRW84_RS04800	COG3064	Membrane
BRW84_RS04805	COG0314	molybdopterin synthase activity
BRW84_RS04815	COG2059	Chromate
BRW84_RS04820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BRW84_RS04825	COG0542	response to heat
BRW84_RS04830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BRW84_RS04835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BRW84_RS04845	COG0436	Aminotransferase
BRW84_RS04860	COG0359	binds to the 23S rRNA
BRW84_RS04865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BRW84_RS04880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BRW84_RS04890	COG0483	inositol monophosphate 1-phosphatase activity
BRW84_RS04905	COG1561	YicC-like family, N-terminal region
BRW84_RS04915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BRW84_RS04920	COG2885	chlorophyll binding
BRW84_RS04935	COG0556	nucleotide-excision repair
BRW84_RS04950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BRW84_RS04955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BRW84_RS04970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BRW84_RS05010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BRW84_RS05020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BRW84_RS05025	COG1215	transferase activity, transferring glycosyl groups
BRW84_RS05025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BRW84_RS05030	COG1216	Glycosyl transferase, family 2
BRW84_RS05040	COG1216	Glycosyl transferase, family 2
BRW84_RS05065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BRW84_RS05075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BRW84_RS05085	COG0586	Pfam SNARE associated Golgi protein
BRW84_RS05110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BRW84_RS05115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BRW84_RS05120	COG2890	protein-(glutamine-N5) methyltransferase activity
BRW84_RS05125	COG4178	(ABC) transporter
BRW84_RS05130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW84_RS05130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW84_RS05135	COG4771	TonB-dependent receptor
BRW84_RS05155	COG3721	Heme iron utilization protein
BRW84_RS05160	COG0702	epimerase
BRW84_RS05170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BRW84_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BRW84_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BRW84_RS05185	COG0123	including yeast histone deacetylase and acetoin utilization protein
BRW84_RS05225	COG0583	DNA-binding transcription factor activity
BRW84_RS05230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BRW84_RS05235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BRW84_RS05240	COG1760	l-serine dehydratase
BRW84_RS05245	COG1760	l-serine dehydratase
BRW84_RS05255	COG0402	S-adenosylhomocysteine deaminase activity
BRW84_RS05260	COG2258	MOSC domain
BRW84_RS05275	COG2226	methyltransferase
BRW84_RS05330	COG1309	transcriptional regulator
BRW84_RS05345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BRW84_RS05350	COG2249	NAD(P)H dehydrogenase (quinone) activity
BRW84_RS05355	COG0519	Catalyzes the synthesis of GMP from XMP
BRW84_RS05435	COG1566	PFAM secretion protein HlyD family protein
BRW84_RS05480	COG0826	peptidase U32
BRW84_RS05485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BRW84_RS05495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BRW84_RS05500	COG1832	CoA-binding protein
BRW84_RS05505	COG1832	CoA-binding protein
BRW84_RS05510	COG1846	Transcriptional regulator
BRW84_RS05515	COG2223	nitrite transmembrane transporter activity
BRW84_RS05520	COG1214	PFAM Peptidase M22, glycoprotease
BRW84_RS05525	COG0456	acetyltransferase
BRW84_RS05535	COG0519	Catalyzes the synthesis of GMP from XMP
BRW84_RS05555	COG2814	Major facilitator Superfamily
BRW84_RS05565	COG3468	outer membrane autotransporter barrel domain protein
BRW84_RS05570	COG0477	Major facilitator Superfamily
BRW84_RS05575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BRW84_RS05585	COG0110	maltose O-acetyltransferase activity
BRW84_RS05600	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BRW84_RS05610	COG0789	Transcriptional regulator
BRW84_RS05615	COG2217	Heavy metal translocating P-type atpase
BRW84_RS05620	COG1322	Protein conserved in bacteria
BRW84_RS05630	COG0277	FAD linked oxidase domain protein
BRW84_RS05635	COG1295	ribonuclease BN
BRW84_RS05640	COG2814	Major facilitator Superfamily
BRW84_RS05645	COG2226	methyltransferase
BRW84_RS05650	COG2267	carboxylic ester hydrolase activity
BRW84_RS05655	COG0156	8-amino-7-oxononanoate synthase activity
BRW84_RS05680	COG0351	phosphomethylpyrimidine kinase
BRW84_RS05690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BRW84_RS05695	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BRW84_RS05700	COG0470	DNA polymerase III
BRW84_RS05705	COG0084	hydrolase, TatD family'
BRW84_RS05720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BRW84_RS05730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BRW84_RS05745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BRW84_RS05755	COG1136	(ABC) transporter
BRW84_RS05760	COG0084	hydrolase, TatD family'
BRW84_RS05770	COG0504	CTP synthase activity
BRW84_RS05775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BRW84_RS05780	COG0148	phosphopyruvate hydratase activity
BRW84_RS05785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BRW84_RS05805	COG0071	Belongs to the small heat shock protein (HSP20) family
BRW84_RS05815	COG0798	PFAM Bile acid sodium symporter
BRW84_RS05900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS05915	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BRW84_RS05915	COG1918	ferrous iron import across plasma membrane
BRW84_RS05940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS05960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BRW84_RS05965	COG0303	'Molybdopterin
BRW84_RS05970	COG0746	molybdenum cofactor guanylyltransferase activity
BRW84_RS05975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BRW84_RS05980	COG1741	Belongs to the pirin family
BRW84_RS05995	COG1215	transferase activity, transferring glycosyl groups
BRW84_RS06000	COG1649	PFAM Uncharacterised BCR, COG1649
BRW84_RS06000	COG0726	polysaccharide deacetylase
BRW84_RS06010	COG1530	ribonuclease E activity
BRW84_RS06015	COG0564	pseudouridine synthase activity
BRW84_RS06020	COG0546	phosphoglycolate phosphatase activity
BRW84_RS06045	COG2176	DNA-directed DNA polymerase activity
BRW84_RS06070	COG0823	Involved in the tonB-independent uptake of proteins
BRW84_RS06085	COG2226	methyltransferase
BRW84_RS06095	COG0583	DNA-binding transcription factor activity
BRW84_RS06115	COG2249	NAD(P)H dehydrogenase (quinone) activity
BRW84_RS06125	COG0697	spore germination
BRW84_RS06185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BRW84_RS06215	COG2207	Transcriptional regulator
BRW84_RS06220	COG1064	alcohol dehydrogenase
BRW84_RS06225	COG0667	Aldo Keto reductase
BRW84_RS06235	COG4221	oxidoreductase activity
BRW84_RS06245	COG1408	metallophosphoesterase
BRW84_RS06270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BRW84_RS06275	COG1063	alcohol dehydrogenase
BRW84_RS06280	COG2199	diguanylate cyclase activity
BRW84_RS06285	COG2199	diguanylate cyclase activity
BRW84_RS06325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BRW84_RS06375	COG3153	acetyltransferase
BRW84_RS06380	COG3457	Alanine racemase
BRW84_RS06415	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BRW84_RS06420	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BRW84_RS06425	COG1074	ATP-dependent DNA helicase activity
BRW84_RS06430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BRW84_RS06475	COG0629	single-stranded DNA binding
BRW84_RS06480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BRW84_RS06490	COG1793	dna ligase
BRW84_RS06490	COG3285	dna ligase
BRW84_RS06510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BRW84_RS06530	COG1562	ergosterol biosynthetic process
BRW84_RS06535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BRW84_RS06540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BRW84_RS06545	COG1454	alcohol dehydrogenase
BRW84_RS06565	COG0179	Fumarylacetoacetate (FAA) hydrolase
BRW84_RS06570	COG2315	Protein conserved in bacteria
BRW84_RS06605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BRW84_RS06610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BRW84_RS06615	COG2733	membrane
BRW84_RS06640	COG3468	outer membrane autotransporter barrel domain protein
BRW84_RS06655	COG1971	Probably functions as a manganese efflux pump
BRW84_RS06685	COG2207	Transcriptional regulator
BRW84_RS06690	COG2807	transmembrane transport
BRW84_RS06700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BRW84_RS06705	COG2391	methyltransferase activity
BRW84_RS06715	COG0640	Transcriptional regulator
BRW84_RS06720	COG1970	mechanosensitive ion channel activity
BRW84_RS06730	COG0730	response to heat
BRW84_RS06735	COG3300	MHYT domain
BRW84_RS06735	COG5001	Diguanylate cyclase
BRW84_RS06740	COG3706	GGDEF domain
BRW84_RS06750	COG2814	Major facilitator Superfamily
BRW84_RS06765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BRW84_RS06805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BRW84_RS06845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BRW84_RS06900	COG2199	diguanylate cyclase activity
BRW84_RS06935	COG3772	lysozyme
BRW84_RS07000	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
BRW84_RS07070	COG0583	DNA-binding transcription factor activity
BRW84_RS07080	COG1253	flavin adenine dinucleotide binding
BRW84_RS07085	COG1115	amino acid carrier protein
BRW84_RS07115	COG0697	spore germination
BRW84_RS07125	COG1522	sequence-specific DNA binding
BRW84_RS07180	COG3728	DNA packaging
BRW84_RS07300	COG0456	acetyltransferase
BRW84_RS07365	COG0545	Peptidyl-prolyl cis-trans isomerase
BRW84_RS07385	COG1966	Carbon starvation protein
BRW84_RS07430	COG2205	protein histidine kinase activity
BRW84_RS07430	COG2198	Histidine kinase
BRW84_RS07430	COG0784	Response regulator, receiver
BRW84_RS07525	COG4106	trans-aconitate 2-methyltransferase activity
BRW84_RS07530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW84_RS07535	COG4535	Mg2 and Co2 transporter CorC
BRW84_RS07545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BRW84_RS07570	COG1113	amino acid transport
BRW84_RS07630	COG1979	alcohol dehydrogenase
BRW84_RS07655	COG1959	2 iron, 2 sulfur cluster binding
BRW84_RS07660	COG0275	rRNA processing
BRW84_RS07715	COG1971	Probably functions as a manganese efflux pump
BRW84_RS07775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BRW84_RS07795	COG1132	(ABC) transporter
BRW84_RS07820	COG1181	Belongs to the D-alanine--D-alanine ligase family
BRW84_RS07885	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW84_RS08040	COG3189	MarR family transcriptional regulator
BRW84_RS08065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BRW84_RS08070	COG4221	oxidoreductase activity
BRW84_RS08125	COG1959	2 iron, 2 sulfur cluster binding
BRW84_RS08135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BRW84_RS08170	COG4106	trans-aconitate 2-methyltransferase activity
BRW84_RS08185	COG3300	MHYT domain
BRW84_RS08185	COG5001	Diguanylate cyclase
BRW84_RS08195	COG1011	Hydrolase
BRW84_RS08200	COG0534	Mate efflux family protein
BRW84_RS08205	COG1199	ATP-dependent helicase activity
BRW84_RS08220	COG2755	lipolytic protein G-D-S-L family
BRW84_RS08220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BRW84_RS08230	COG4656	Part of a membrane complex involved in electron transport
BRW84_RS08275	COG1203	CRISPR-associated helicase, Cas3
BRW84_RS08295	COG1733	regulation of RNA biosynthetic process
BRW84_RS08305	COG1335	isochorismatase
BRW84_RS08310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS08335	COG0493	'glutamate synthase
BRW84_RS08340	COG0167	dihydroorotate dehydrogenase activity
BRW84_RS08340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BRW84_RS08365	COG3550	peptidyl-serine autophosphorylation
BRW84_RS08370	COG1396	sequence-specific DNA binding
BRW84_RS08395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW84_RS08410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW84_RS08415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRW84_RS08420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRW84_RS08455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BRW84_RS08470	COG0028	Belongs to the TPP enzyme family
BRW84_RS08495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BRW84_RS08500	COG0508	dehydrogenase complex catalyzes the overall conversion of
BRW84_RS08505	COG0567	Dehydrogenase, E1 component
BRW84_RS08510	COG3468	outer membrane autotransporter barrel domain protein
BRW84_RS08520	COG0372	Belongs to the citrate synthase family
BRW84_RS08525	COG0561	phosphatase activity
BRW84_RS08530	COG2207	Transcriptional regulator
BRW84_RS08530	COG1609	Transcriptional regulator
BRW84_RS08595	COG0598	Magnesium transport protein CorA
BRW84_RS08605	COG2814	Major facilitator Superfamily
BRW84_RS08610	COG2814	Major facilitator Superfamily
BRW84_RS08635	COG0667	Aldo Keto reductase
BRW84_RS08640	COG0667	Aldo Keto reductase
BRW84_RS08705	COG5002	protein histidine kinase activity
BRW84_RS08710	COG0745	RESPONSE REGULATOR receiver
BRW84_RS08715	COG0704	Plays a role in the regulation of phosphate uptake
BRW84_RS08720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BRW84_RS08730	COG0573	inorganic phosphate transmembrane transporter activity
BRW84_RS08750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BRW84_RS08755	COG1702	phosphate starvation-inducible protein PhoH
BRW84_RS08760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BRW84_RS08765	COG0784	Response regulator, receiver
BRW84_RS08765	COG2205	protein histidine kinase activity
BRW84_RS08810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS08825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS08830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BRW84_RS08850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BRW84_RS08860	COG0004	ammonium transporteR
BRW84_RS08865	COG0347	Belongs to the P(II) protein family
BRW84_RS08900	COG2194	sulfuric ester hydrolase activity
BRW84_RS08905	COG0778	Nitroreductase
BRW84_RS08925	COG5295	Hep Hag repeat protein
BRW84_RS08950	COG0668	transmembrane transport
BRW84_RS08955	COG2195	Cleaves the N-terminal amino acid of tripeptides
BRW84_RS08985	COG0318	PFAM AMP-dependent synthetase and ligase
BRW84_RS09000	COG0604	alcohol dehydrogenase
BRW84_RS09005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BRW84_RS09020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BRW84_RS09030	COG5001	Diguanylate cyclase
BRW84_RS09030	COG3300	MHYT domain
BRW84_RS09035	COG4213	ABC transporter substrate-binding protein
BRW84_RS09105	COG1278	Cold shock
BRW84_RS09110	COG3645	SOS response
BRW84_RS09215	COG0740	serine-type endopeptidase activity
BRW84_RS09220	COG4695	Portal protein
BRW84_RS09425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BRW84_RS09435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BRW84_RS09455	COG0330	HflC and HflK could
BRW84_RS09470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BRW84_RS09480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BRW84_RS09485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW84_RS09490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW84_RS09495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BRW84_RS09500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW84_RS09520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BRW84_RS09525	COG0575	Belongs to the CDS family
BRW84_RS09535	COG0233	cytoplasmic translational termination
BRW84_RS09540	COG0528	UMP kinase activity
BRW84_RS09545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BRW84_RS09550	COG0052	Belongs to the universal ribosomal protein uS2 family
BRW84_RS09555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BRW84_RS09555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BRW84_RS09560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BRW84_RS09565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BRW84_RS09570	COG0740	serine-type endopeptidase activity
BRW84_RS09575	COG0544	peptidyl-prolyl cis-trans isomerase activity
BRW84_RS09585	COG0492	ferredoxin-NADP+ reductase activity
BRW84_RS09590	COG2878	Part of a membrane complex involved in electron transport
BRW84_RS09595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BRW84_RS09600	COG1187	pseudouridine synthase activity
BRW84_RS09605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BRW84_RS09615	COG3459	Glycosyltransferase 36 associated
BRW84_RS09620	COG2855	membrane
BRW84_RS09630	COG0708	Exodeoxyribonuclease III
BRW84_RS09640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BRW84_RS09645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BRW84_RS09650	COG0783	Belongs to the Dps family
BRW84_RS09655	COG0076	glutamate decarboxylase activity
BRW84_RS09660	COG2066	Belongs to the glutaminase family
BRW84_RS09665	COG0531	amino acid
BRW84_RS09670	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BRW84_RS09675	COG0791	NLP P60 protein
BRW84_RS09685	COG3852	Histidine kinase
BRW84_RS09690	COG0174	glutamine synthetase
BRW84_RS09700	COG0545	Peptidyl-prolyl cis-trans isomerase
BRW84_RS09705	COG2003	Belongs to the UPF0758 family
BRW84_RS09710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BRW84_RS09720	COG0217	transcriptional regulatory protein
BRW84_RS09725	COG0151	Belongs to the GarS family
BRW84_RS09730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BRW84_RS09735	COG0799	negative regulation of ribosome biogenesis
BRW84_RS09740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BRW84_RS09745	COG0424	maF-like protein
BRW84_RS09755	COG1442	glycosyl transferase family 8
BRW84_RS09775	COG0463	Glycosyl transferase, family 2
BRW84_RS09785	COG1132	(ABC) transporter
BRW84_RS09800	COG0513	Belongs to the DEAD box helicase family
BRW84_RS09835	COG0668	transmembrane transport
BRW84_RS09845	COG0024	Methionine aminopeptidase
BRW84_RS09850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BRW84_RS09855	COG1187	pseudouridine synthase activity
BRW84_RS09860	COG0242	peptide deformylase activity
BRW84_RS09865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BRW84_RS09870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BRW84_RS09890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BRW84_RS09895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BRW84_RS09900	COG0330	HflC and HflK could
BRW84_RS09905	COG0330	HflC and HflK could
BRW84_RS09910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BRW84_RS09915	COG1923	regulation of RNA biosynthetic process
BRW84_RS09920	COG1160	GTP binding
BRW84_RS09925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BRW84_RS09935	COG0124	histidyl-tRNA synthetase
BRW84_RS09940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BRW84_RS09950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BRW84_RS09960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW84_RS09965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BRW84_RS09990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BRW84_RS09995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BRW84_RS10005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BRW84_RS10010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BRW84_RS10015	COG0416	fatty acid biosynthetic process
BRW84_RS10020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BRW84_RS10030	COG0424	maF-like protein
BRW84_RS10035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BRW84_RS10040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BRW84_RS10045	COG0583	DNA-binding transcription factor activity
BRW84_RS10050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BRW84_RS10065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BRW84_RS10085	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BRW84_RS10090	COG1024	Enoyl-CoA hydratase
BRW84_RS10095	COG2917	probably involved in intracellular septation
BRW84_RS10100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BRW84_RS10105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BRW84_RS10110	COG1388	LysM domain
BRW84_RS10110	COG4942	peptidase
BRW84_RS10115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRW84_RS10120	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BRW84_RS10130	COG0776	regulation of translation
BRW84_RS10135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BRW84_RS10135	COG0072	phenylalanine-tRNA ligase activity
BRW84_RS10140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BRW84_RS10145	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BRW84_RS10150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BRW84_RS10155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BRW84_RS10160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BRW84_RS10170	COG1538	Outer membrane efflux protein
BRW84_RS10180	COG5001	Diguanylate cyclase
BRW84_RS10180	COG3300	MHYT domain
BRW84_RS10190	COG2274	protein secretion by the type I secretion system
BRW84_RS10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW84_RS10205	COG0166	Belongs to the GPI family
BRW84_RS10215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BRW84_RS10220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BRW84_RS10230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW84_RS10235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BRW84_RS10250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BRW84_RS10255	COG1592	Rubrerythrin
BRW84_RS10270	COG0527	aspartate kinase activity
BRW84_RS10275	COG0037	tRNA processing
BRW84_RS10280	COG0825	malonyl-CoA metabolic process
BRW84_RS10290	COG0215	cysteine-tRNA ligase activity
BRW84_RS10295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BRW84_RS10300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BRW84_RS10305	COG2094	Belongs to the DNA glycosylase MPG family
BRW84_RS10320	COG1045	serine acetyltransferase
BRW84_RS10325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BRW84_RS10330	COG0557	exoribonuclease II activity
BRW84_RS10360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BRW84_RS10370	COG1185	polyribonucleotide nucleotidyltransferase activity
BRW84_RS10375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BRW84_RS10390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BRW84_RS10395	COG1183	phosphatidylcholine synthase activity
BRW84_RS10400	COG0688	phosphatidylethanolamine metabolic process
BRW84_RS10410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BRW84_RS10415	COG1881	PFAM PEBP family protein
BRW84_RS10420	COG0071	Belongs to the small heat shock protein (HSP20) family
BRW84_RS10425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BRW84_RS10430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BRW84_RS10430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BRW84_RS10435	COG1643	Atp-dependent helicase
BRW84_RS10440	COG0583	DNA-binding transcription factor activity
BRW84_RS10455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BRW84_RS10500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BRW84_RS10545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BRW84_RS10550	COG0287	Prephenate dehydrogenase
BRW84_RS10555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BRW84_RS10565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BRW84_RS10580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BRW84_RS10590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BRW84_RS10595	COG1560	Kdo2-lipid A biosynthetic process
BRW84_RS10600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BRW84_RS10605	COG2326	polyphosphate kinase activity
BRW84_RS10620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BRW84_RS10625	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BRW84_RS10630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BRW84_RS10645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BRW84_RS10650	COG3585	molybdate ion transport
BRW84_RS10650	COG2005	Transcriptional regulator
BRW84_RS10665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BRW84_RS10670	COG1012	belongs to the aldehyde dehydrogenase family
BRW84_RS10675	COG3383	formate dehydrogenase (NAD+) activity
BRW84_RS10680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRW84_RS10690	COG1763	Mo-molybdopterin cofactor biosynthetic process
BRW84_RS10695	COG4166	transmembrane transport
BRW84_RS10700	COG0196	riboflavin kinase activity
BRW84_RS10705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BRW84_RS10710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BRW84_RS10715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BRW84_RS10720	COG0756	dUTP diphosphatase activity
BRW84_RS10740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BRW84_RS10745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BRW84_RS10750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BRW84_RS10755	COG0316	Belongs to the HesB IscA family
BRW84_RS10760	COG1959	2 iron, 2 sulfur cluster binding
BRW84_RS10765	COG1104	cysteine desulfurase activity
BRW84_RS10770	COG0822	iron-sulfur transferase activity
BRW84_RS10775	COG0316	Belongs to the HesB IscA family
BRW84_RS10785	COG0443	Heat shock 70 kDa protein
BRW84_RS10790	COG0633	Ferredoxin
BRW84_RS10795	COG2975	iron-sulfur cluster assembly
BRW84_RS10800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BRW84_RS10810	COG2914	Belongs to the UPF0125 (RnfH) family
BRW84_RS10830	COG0028	Belongs to the TPP enzyme family
BRW84_RS10835	COG0440	acetolactate synthase activity
BRW84_RS10840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BRW84_RS10845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BRW84_RS10855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BRW84_RS10865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BRW84_RS10875	COG0514	ATP-dependent DNA helicase (RecQ)
BRW84_RS10880	COG1968	undecaprenyl-diphosphatase activity
BRW84_RS10885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BRW84_RS10895	COG1538	Outer membrane efflux protein
BRW84_RS10900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BRW84_RS10950	COG0205	6-phosphofructokinase activity
BRW84_RS10955	COG0564	pseudouridine synthase activity
BRW84_RS10960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BRW84_RS10995	COG0012	GTP binding
BRW84_RS11005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BRW84_RS11015	COG0742	ribosomal rna small subunit methyltransferase
BRW84_RS11020	COG0612	Peptidase, M16
BRW84_RS11025	COG0612	Peptidase, M16
BRW84_RS11035	COG2884	Cell division ATP-binding protein ftsE
BRW84_RS11040	COG2177	Part of the ABC transporter FtsEX involved in
BRW84_RS11050	COG2226	methyltransferase
BRW84_RS11065	COG0484	heat shock protein binding
BRW84_RS11070	COG0443	Heat shock 70 kDa protein
BRW84_RS11075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BRW84_RS11080	COG0497	DNA recombination
BRW84_RS11090	COG1420	regulation of RNA biosynthetic process
BRW84_RS11095	COG0284	orotidine-5'-phosphate decarboxylase activity
BRW84_RS11105	COG5001	Diguanylate cyclase
BRW84_RS11105	COG5002	protein histidine kinase activity
BRW84_RS11120	COG0563	adenylate kinase activity
BRW84_RS11125	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BRW84_RS11130	COG2835	tetraacyldisaccharide 4'-kinase activity
BRW84_RS11135	COG1663	tetraacyldisaccharide 4'-kinase activity
BRW84_RS11140	COG0848	biopolymer transport protein
BRW84_RS11145	COG0811	peptide transport
BRW84_RS11150	COG0165	Argininosuccinate lyase
BRW84_RS11155	COG0129	dihydroxy-acid dehydratase activity
BRW84_RS11160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BRW84_RS11165	COG2137	regulation of response to DNA damage stimulus
BRW84_RS11170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BRW84_RS11180	COG1570	exodeoxyribonuclease VII activity
BRW84_RS11185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BRW84_RS11205	COG0019	diaminopimelate decarboxylase activity
BRW84_RS11210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BRW84_RS11220	COG1324	tolerance protein
BRW84_RS11225	COG0203	ribosomal protein L17
BRW84_RS11230	COG0202	RNA polymerase activity
BRW84_RS11235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BRW84_RS11240	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BRW84_RS11245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BRW84_RS11250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BRW84_RS11255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BRW84_RS11260	COG0201	protein transport
BRW84_RS11265	COG0200	Binds to the 23S rRNA
BRW84_RS11275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BRW84_RS11280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BRW84_RS11285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BRW84_RS11290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BRW84_RS11295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BRW84_RS11300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BRW84_RS11305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BRW84_RS11310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BRW84_RS11315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BRW84_RS11320	COG0255	Belongs to the universal ribosomal protein uL29 family
BRW84_RS11325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BRW84_RS11330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BRW84_RS11335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BRW84_RS11340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BRW84_RS11345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BRW84_RS11350	COG0089	rRNA binding
BRW84_RS11355	COG0088	Forms part of the polypeptide exit tunnel