locus-tag class description HUB98_RS00005 ENOG4108HKT sucrose-6-phosphate hydrolase HUB98_RS00025 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUB98_RS00040 ENOG4105UEI Transcriptional Regulator AraC Family HUB98_RS00055 ENOG4105E8R UPF0173 metal-dependent hydrolase HUB98_RS00065 ENOG4105CG3 alpha amylase, catalytic region HUB98_RS00070 ENOG4105C5Y PTS System HUB98_RS00080 ENOG4107QM2 Aldo Keto reductase HUB98_RS00100 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS00105 ENOG4108RVA ribokinase HUB98_RS00110 ENOG4105F8D glycoside hydrolase family 4 HUB98_RS00125 ENOG4105KRS Proteinase inhibitor HUB98_RS00145 ENOG4105DUM transcriptional regulator, lysR family HUB98_RS00150 ENOG4105XPP Protein of unknown function (DUF1275) HUB98_RS00160 ENOG4105C2C drug resistance transporter, Bcr CflA HUB98_RS00170 ENOG4107XC4 flavin reductase domain protein, FMN-binding HUB98_RS00180 ENOG4105NTD Inherit from COG: Hydrolase HUB98_RS00185 ENOG4107TDE lipolytic protein G-D-S-L family HUB98_RS00190 ENOG4105KJM monovalent cation h antiporter subunit g HUB98_RS00200 ENOG4105SC1 monovalent cation H antiporter subunit E HUB98_RS00205 ENOG4108JPZ Monovalent cation H antiporter subunit D HUB98_RS00210 ENOG4108ZE9 Monovalent cation H antiporter subunit C HUB98_RS00215 ENOG4105D65 subunit l HUB98_RS00220 ENOG4105BZU Histidine kinase HUB98_RS00230 ENOG4105BZU Histidine kinase HUB98_RS00245 ENOG41090A1 ferritin HUB98_RS00250 ENOG4107VMI polysaccharide deacetylase HUB98_RS00255 ENOG4108S01 response regulator HUB98_RS00260 ENOG4108ZGX Histidine kinase HUB98_RS00265 ENOG4105ECK Fatty Acid Desaturase HUB98_RS00270 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HUB98_RS00275 ENOG4105DKQ ROK family HUB98_RS00280 ENOG4105DKQ ROK family HUB98_RS00310 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS00335 ENOG4105DEF Extracellular solute-binding protein, family 5 HUB98_RS00370 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUB98_RS00380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUB98_RS00385 ENOG4105EFI regulatoR HUB98_RS00390 ENOG4105BZU Histidine kinase HUB98_RS00395 ENOG4107RRM 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUB98_RS00400 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUB98_RS00405 ENOG4105EQ0 Major Facilitator superfamily HUB98_RS00410 ENOG4108IG5 Transcriptional regulator HUB98_RS00420 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS00440 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUB98_RS00460 ENOG4105CPC Aldo Keto reductase HUB98_RS00470 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUB98_RS00480 ENOG4105FTQ Dna gyrase HUB98_RS00485 ENOG4108TVJ Nitroreductase HUB98_RS00495 ENOG4108VXD carboxy-peptidase HUB98_RS00520 ENOG4105C5H ABC transporter HUB98_RS00525 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUB98_RS00535 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUB98_RS00540 ENOG4105CDY transcriptional regulatory protein HUB98_RS00560 ENOG4107Y1M NIF3 (NGG1p interacting factor 3) HUB98_RS00580 ENOG4107QRT dEAD DEAH box helicase HUB98_RS00605 ENOG4107414 GntR family transcriptional regulator HUB98_RS00610 ENOG4107HQ7 repeat protein HUB98_RS00620 ENOG4105DKG l-rhamnose isomerase HUB98_RS00625 ENOG4105CN5 Metallo-Beta-Lactamase HUB98_RS00640 ENOG4105C5Y PTS System HUB98_RS00645 ENOG4105WEF catalase HUB98_RS00655 ENOG4105CS2 ec 3.2.1.21 HUB98_RS00660 ENOG4105CID antiterminator HUB98_RS00670 ENOG41080Y5 BioY family HUB98_RS00675 ENOG4108JJB ABC transporter HUB98_RS00680 ENOG4108JJB ABC transporter HUB98_RS00695 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 HUB98_RS00710 ENOG4105CHR reductase HUB98_RS00715 ENOG41087NI Sulfite exporter TauE/SafE HUB98_RS00725 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HUB98_RS00730 ENOG4105E5W Transporter HUB98_RS00735 ENOG4105BZ1 (ABC) transporter HUB98_RS00740 ENOG4108JJA ABC, transporter HUB98_RS00745 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUB98_RS00760 ENOG4105J7D transcriptional regulator HUB98_RS00765 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUB98_RS00785 ENOG4108JCI Transcriptional regulator HUB98_RS00795 ENOG4108SUT Major Facilitator Superfamily HUB98_RS00810 ENOG4105VCH membrane HUB98_RS00815 ENOG4105ECQ AraC Family Transcriptional Regulator HUB98_RS00835 ENOG4105CMD Transcriptional regulator, GntR family HUB98_RS00845 ENOG4105XN3 extracellular solute-binding protein family 1 HUB98_RS00855 ENOG4105EG2 ABC transporter, permease HUB98_RS00860 ENOG4105C8I hydrolase, family 38 HUB98_RS00865 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUB98_RS00875 ENOG4105CK5 oxidoreductase HUB98_RS00880 ENOG4108QBF Transcriptional regulator HUB98_RS00890 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HUB98_RS00905 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUB98_RS00925 ENOG4105RJZ Transcriptional regulator HUB98_RS00930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUB98_RS00935 ENOG4105HEI LysR family (Transcriptional regulator HUB98_RS00950 ENOG4105CPQ Dehydrogenase HUB98_RS00965 ENOG4106ZGR Transcriptional regulator HUB98_RS00970 ENOG4107VFR oxidoreductase HUB98_RS00990 ENOG4105BZU Histidine kinase HUB98_RS01005 ENOG4105BZ1 (ABC) transporter HUB98_RS01010 ENOG410645S MarR family Transcriptional regulator HUB98_RS01020 ENOG4107QVI Methyltransferase, type 11 HUB98_RS01030 ENOG4105C1J atp-dependent rna helicase HUB98_RS01035 ENOG4105MSB protein, conserved in bacteria HUB98_RS01060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS01065 ENOG4108ZMQ domain protein HUB98_RS01070 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUB98_RS01085 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUB98_RS01090 ENOG4105E1K spore germination protein HUB98_RS01100 ENOG4108Q5U germination protein, ger(x)c family HUB98_RS01145 ENOG4105DQ6 Transposase HUB98_RS01160 ENOG4105NX3 Membrane HUB98_RS01170 ENOG4108TN2 lmbE family HUB98_RS01190 ENOG4105CJ1 ABC, transporter HUB98_RS01195 ENOG4107ZT5 Thiol disulfide interchange protein HUB98_RS01200 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUB98_RS01215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUB98_RS01225 ENOG4105VUF Transcriptional regulator HUB98_RS01230 ENOG4105DQ4 alcohol dehydrogenase HUB98_RS01235 ENOG4105EEM helicase HUB98_RS01255 ENOG4107Y2X deaminase HUB98_RS01270 ENOG4105EMU Dehydrogenase HUB98_RS01275 ENOG4105VUF Transcriptional regulator HUB98_RS01300 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS01305 ENOG4108RVA ribokinase HUB98_RS01310 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HUB98_RS01315 ENOG4105C2J ABC transporter HUB98_RS01320 ENOG4105CNN ABC, transporter HUB98_RS01325 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUB98_RS01330 ENOG4105DFA alanine racemase domain protein HUB98_RS01335 ENOG4105DKK Benzoate HUB98_RS01340 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS01345 ENOG4107R0W ABC transporter HUB98_RS01365 ENOG4105E7U AraC family transcriptional regulator HUB98_RS01375 ENOG4105EQD regulatoR HUB98_RS01375 ENOG4105EQD regulatoR HUB98_RS01380 ENOG4105C2F Histidine kinase HUB98_RS01395 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS01400 ENOG4108MYR Secreted protein HUB98_RS01405 ENOG41067XF inhibitor HUB98_RS01410 ENOG4105GGE ribonuclease HUB98_RS01420 ENOG41075H3 AraC family transcriptional regulator HUB98_RS01430 ENOG4105DSG hydrolase family 43 HUB98_RS01435 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS01440 ENOG4105C2F Histidine kinase HUB98_RS01445 ENOG4105EQD regulatoR HUB98_RS01465 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUB98_RS01490 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUB98_RS01495 ENOG4105DRS transport system, permease HUB98_RS01505 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HUB98_RS01515 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS01520 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS01560 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS01565 ENOG4105EQD regulatoR HUB98_RS01570 ENOG4105C2F Histidine kinase HUB98_RS01580 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS01590 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUB98_RS01600 ENOG4105BZU Histidine kinase HUB98_RS01605 ENOG4105NI3 Protein of unknown function (DUF3237) HUB98_RS01610 ENOG4108RZE Tetr family transcriptional regulator HUB98_RS01635 ENOG4107T94 Endo-14-beta-xylanase HUB98_RS01660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUB98_RS01665 ENOG4105KVH Transcriptional regulator HUB98_RS01690 ENOG4108JJ9 ABC, transporter HUB98_RS01695 ENOG4108JJ8 (ABC) transporter HUB98_RS01705 ENOG4108Z6Z Transcriptional regulator HUB98_RS01725 ENOG4107TXC Transcriptional regulator HUB98_RS01750 ENOG4105CID antiterminator HUB98_RS01755 ENOG4105C5Y PTS System HUB98_RS01760 ENOG4105CS2 ec 3.2.1.21 HUB98_RS01765 ENOG4105DUM transcriptional regulator, lysR family HUB98_RS01795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS01805 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUB98_RS01825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS01830 ENOG4105BZU Histidine kinase HUB98_RS01860 ENOG4105CS2 ec 3.2.1.21 HUB98_RS01865 ENOG4105CS2 ec 3.2.1.21 HUB98_RS01870 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUB98_RS01880 ENOG41087PP glycosyltransferase MGT family HUB98_RS01900 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS01910 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS01925 ENOG4105EQD regulatoR HUB98_RS01930 ENOG4105C2F Histidine kinase HUB98_RS01935 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS01965 ENOG4105C0B DNA polymerase III (alpha subunit) HUB98_RS01980 ENOG4105E0C molybdate abc transporter HUB98_RS01985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS01995 ENOG4105E0C molybdate abc transporter HUB98_RS02000 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUB98_RS02010 ENOG4105E2V Glycosyltransferase 36 HUB98_RS02025 ENOG41063TF transcriptional regulator (AraC HUB98_RS02030 ENOG4108PSK reductase HUB98_RS02035 ENOG4105CQM Urea amidohydrolase subunit alpha HUB98_RS02040 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUB98_RS02045 ENOG41086D8 Transcriptional regulator HUB98_RS02055 ENOG4105DKQ ROK family HUB98_RS02060 ENOG410874W AraC family transcriptional regulator HUB98_RS02065 ENOG4105CT4 transporter HUB98_RS02070 ENOG4105CNT hydrolase family 2 HUB98_RS02100 ENOG4105E7U AraC family transcriptional regulator HUB98_RS02115 ENOG4105C01 Dihydroxy-acid dehydratase HUB98_RS02120 ENOG4105DSG hydrolase family 43 HUB98_RS02135 ENOG4105DJ2 Major Facilitator Superfamily HUB98_RS02165 ENOG4105EPR degv family HUB98_RS02175 ENOG4105JDN Copper resistance protein HUB98_RS02190 ENOG4108HRK Histidine kinase HUB98_RS02195 ENOG4107VQW regulatoR HUB98_RS02210 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS02225 ENOG4105CUB amino acid HUB98_RS02235 ENOG4105DCF alanine dehydrogenase HUB98_RS02250 ENOG4105VPX protein, conserved in bacteria HUB98_RS02265 ENOG41082J7 Rhodanese domain protein HUB98_RS02270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS02275 ENOG4105CKI cobalamin synthesis protein HUB98_RS02305 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS02315 ENOG4105EQD regulatoR HUB98_RS02320 ENOG4105C2F Histidine kinase HUB98_RS02325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUB98_RS02340 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS02355 ENOG4108QY0 Membrane HUB98_RS02380 ENOG4105DA5 (ABC) transporter HUB98_RS02395 ENOG4105DUM transcriptional regulator, lysR family HUB98_RS02410 ENOG4105F9F transposase HUB98_RS02420 ENOG4105C6Z Gluconate HUB98_RS02430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUB98_RS02450 ENOG4105ETD TRANSCRIPTIONal HUB98_RS02460 ENOG4105VCP PTS System HUB98_RS02465 ENOG4105CK1 PTS System HUB98_RS02470 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUB98_RS02475 ENOG4108HRK Histidine kinase HUB98_RS02480 ENOG4105EQD regulatoR HUB98_RS02495 ENOG4105DRS transport system, permease HUB98_RS02515 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUB98_RS02525 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUB98_RS02530 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUB98_RS02535 ENOG4105EXW epimerase dehydratase HUB98_RS02540 ENOG4105JVQ RNA Polymerase HUB98_RS02545 ENOG4108P49 AntiSigma factor HUB98_RS02550 ENOG4105DT9 hydrolase family 43 HUB98_RS02555 ENOG4105JVQ RNA Polymerase HUB98_RS02560 ENOG4108P49 AntiSigma factor HUB98_RS02620 ENOG4105H3G oxidoreductase HUB98_RS02625 ENOG41082YX Transcriptional regulator, arsr family HUB98_RS02630 ENOG4107R5R arsenical pump membrane protein HUB98_RS02635 ENOG4108UXE Protein tyrosine phosphatase HUB98_RS02645 ENOG4105HHM rdd domain containing protein HUB98_RS02650 ENOG410874W AraC family transcriptional regulator HUB98_RS02670 ENOG4108P49 AntiSigma factor HUB98_RS02690 ENOG4105DEG Vwa containing coxe family protein HUB98_RS02700 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUB98_RS02720 ENOG4105C7K acetolactate synthase HUB98_RS02725 ENOG4105CHR reductase HUB98_RS02735 ENOG4105NRA 50s ribosomal protein l31 type b HUB98_RS02745 ENOG4105CPQ Dehydrogenase HUB98_RS02760 ENOG4105W4W Transcriptional regulator HUB98_RS02765 ENOG4105C26 Dehydrogenase HUB98_RS02775 ENOG4107XBN GntR Family Transcriptional Regulator HUB98_RS02780 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HUB98_RS02785 ENOG4105DMW Dehydrogenase reductase HUB98_RS02790 ENOG4108QY0 Membrane HUB98_RS02810 ENOG4105DSE periplasmic solute binding protein HUB98_RS02820 ENOG4105DIK (ABC) transporter HUB98_RS02830 ENOG4105CKI cobalamin synthesis protein HUB98_RS02835 ENOG4108PJD permease HUB98_RS02845 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HUB98_RS02850 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HUB98_RS02855 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HUB98_RS02860 ENOG4105D9N nucleoside HUB98_RS02865 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUB98_RS02870 ENOG4107RHR regulatoR HUB98_RS02875 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUB98_RS02890 ENOG4105DET Rhamnulokinase HUB98_RS02900 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS02915 ENOG4105EE0 oxidoreductase HUB98_RS02945 ENOG4105DDV Transcriptional regulator (LacI family HUB98_RS02950 ENOG4105CBT Fructose-1,6-bisphosphatase HUB98_RS02965 ENOG4107YV9 domain protein HUB98_RS02970 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUB98_RS02985 ENOG4105XRQ Xanthine dehydrogenase accessory factor HUB98_RS02990 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUB98_RS02995 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUB98_RS03000 ENOG4105C5R Aminotransferase HUB98_RS03010 ENOG41084YZ Hydrolase HUB98_RS03015 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HUB98_RS03020 ENOG4105G9B Transcriptional regulator HUB98_RS03030 ENOG4105C9Q fumarate hydratase class II HUB98_RS03060 ENOG4105EMN RNA polymerase sigma factor HUB98_RS03075 ENOG4105C37 (CBS) domain HUB98_RS03090 ENOG4108VKI Cell wall hydrolase HUB98_RS03100 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUB98_RS03145 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUB98_RS03170 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUB98_RS03180 ENOG4105CUB amino acid HUB98_RS03185 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUB98_RS03195 ENOG4105DV0 amidase (EC 3.5.1.4 HUB98_RS03200 ENOG4105EIG urea carboxylase-associated protein 1 HUB98_RS03220 ENOG41067XF inhibitor HUB98_RS03230 ENOG4108SWU Histidine kinase HUB98_RS03235 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS03240 ENOG4105DHF Membrane HUB98_RS03245 ENOG4105CHR reductase HUB98_RS03260 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HUB98_RS03265 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUB98_RS03305 ENOG41069ER domain protein HUB98_RS03310 ENOG4108RS6 transposase HUB98_RS03315 ENOG4105CDA abc transporter atp-binding protein HUB98_RS03320 ENOG4108HW3 (ABC) transporter HUB98_RS03330 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HUB98_RS03335 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUB98_RS03340 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUB98_RS03350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS03365 ENOG4108ISG Major Facilitator HUB98_RS03380 ENOG4105C9U ATP-dependent DNA helicase RecQ HUB98_RS03385 ENOG4105I3K Ferric uptake regulator, Fur family HUB98_RS03390 ENOG4105BZ8 glutamate synthase HUB98_RS03395 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUB98_RS03400 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUB98_RS03410 ENOG4105C7S Dehydrogenase HUB98_RS03415 ENOG4105CPP Dehydrogenase, E1 component HUB98_RS03430 ENOG4105KJF protein tyrosine phosphatase HUB98_RS03435 ENOG4105EN6 Membrane HUB98_RS03440 ENOG4105FJ0 thiamine HUB98_RS03450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS03455 ENOG4105D06 uba thif-type nad fad binding protein HUB98_RS03460 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUB98_RS03465 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUB98_RS03470 ENOG41080HI glycine oxidase HUB98_RS03475 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUB98_RS03480 ENOG4105C5H ABC transporter HUB98_RS03535 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HUB98_RS03540 ENOG4105DKW ABC transporter HUB98_RS03555 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUB98_RS03560 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUB98_RS03565 ENOG4105D4U had-superfamily hydrolase, subfamily iia HUB98_RS03570 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUB98_RS03575 ENOG4105C3R Methionine synthase HUB98_RS03580 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HUB98_RS03585 ENOG4107XBN GntR Family Transcriptional Regulator HUB98_RS03610 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUB98_RS03615 ENOG4105C26 Dehydrogenase HUB98_RS03655 ENOG4105C4R Atp-dependent dna helicase HUB98_RS03660 ENOG4105CPB ATP-dependent endonuclease of the OLD family HUB98_RS03675 ENOG4108RAV Conserved protein HUB98_RS03680 ENOG4108J53 cell adhesion domain-containing protein HUB98_RS03720 ENOG4105EKQ RNA-directed DNA polymerase HUB98_RS03730 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HUB98_RS03770 ENOG4105W5Q DNA repair protein (RadC HUB98_RS03790 ENOG4108UUM single-stranded DNA-binding protein HUB98_RS03830 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUB98_RS03875 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HUB98_RS03930 ENOG4107QHF type ii secretion system protein e HUB98_RS03950 ENOG4105DR5 peptidase HUB98_RS03980 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUB98_RS03990 ENOG4105MCT stage V sporulation protein S HUB98_RS04025 ENOG4105C7H Helicase, RecD TraA family HUB98_RS04045 ENOG4108IMY Transcriptional regulator HUB98_RS04065 ENOG4105F9F transposase HUB98_RS04105 ENOG4105C5F glutamine synthetase HUB98_RS04110 ENOG4105KV4 Transcriptional regulator HUB98_RS04115 ENOG4105CXI aluminum resistance protein HUB98_RS04120 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUB98_RS04125 ENOG4106F1P AAA ATPase, central domain protein HUB98_RS04135 ENOG4105BZ4 penicillin-binding protein HUB98_RS04140 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HUB98_RS04155 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUB98_RS04160 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HUB98_RS04175 ENOG4108QEG Membrane HUB98_RS04180 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HUB98_RS04190 ENOG4105D2X ABC transporter substrate-binding protein HUB98_RS04195 ENOG4105CTD carboxy-peptidase HUB98_RS04200 ENOG4108V2W Carbonate dehydratase HUB98_RS04240 ENOG4105CNG UPF0061 protein HUB98_RS04250 ENOG4105FE9 pseudouridine synthase HUB98_RS04260 ENOG4108JPW Aminotransferase HUB98_RS04265 ENOG4105CPQ Dehydrogenase HUB98_RS04270 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUB98_RS04285 ENOG4108X4Q Hydrolase HUB98_RS04300 ENOG4105CS2 ec 3.2.1.21 HUB98_RS04305 ENOG4105C5Y PTS System HUB98_RS04310 ENOG4105CID antiterminator HUB98_RS04335 ENOG4107RN3 metallophosphoesterase HUB98_RS04340 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUB98_RS04350 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUB98_RS04355 ENOG4105CMU LysR family (Transcriptional regulator HUB98_RS04360 ENOG4105CBS Chea signal transduction histidine kinase HUB98_RS04365 ENOG4108ZGA chew protein HUB98_RS04370 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS04395 ENOG4107S1E Beta-lactamase HUB98_RS04410 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUB98_RS04460 ENOG4107RYR Transcriptional regulator, Crp Fnr family HUB98_RS04490 ENOG4108YYC ycei family HUB98_RS04495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS04500 ENOG4105BZU Histidine kinase HUB98_RS04530 ENOG4105NQC Flavodoxin HUB98_RS04535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HUB98_RS04540 ENOG4108YBP pseudouridine synthase HUB98_RS04545 ENOG41080UX Methyltransferase HUB98_RS04550 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUB98_RS04560 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUB98_RS04570 ENOG41067TZ transcriptional regulator, MarR family HUB98_RS04590 ENOG4105CJ1 ABC, transporter HUB98_RS04600 ENOG4105K4I Scp-like extracellular HUB98_RS04610 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HUB98_RS04615 ENOG4105CAY ferredoxin--nadp reductase HUB98_RS04630 ENOG4105BZ1 (ABC) transporter HUB98_RS04635 ENOG4105BZ1 (ABC) transporter HUB98_RS04640 ENOG410890F Dynamin family HUB98_RS04650 ENOG4105CSM endonuclease III HUB98_RS04665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUB98_RS04670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUB98_RS04680 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUB98_RS04685 ENOG4105C5Q Transcriptional regulator HUB98_RS04690 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUB98_RS04700 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUB98_RS04705 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUB98_RS04715 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HUB98_RS04720 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HUB98_RS04725 ENOG4105CR5 Class II aldolase adducin family protein HUB98_RS04750 ENOG4105C5S asparaginyl-tRNA synthetase HUB98_RS04755 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUB98_RS04760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUB98_RS04780 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUB98_RS04785 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUB98_RS04790 ENOG4105DVT helicase HUB98_RS04800 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUB98_RS04810 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUB98_RS04820 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUB98_RS04825 ENOG4105CPK Glycosyl transferase (Group 1 HUB98_RS04830 ENOG4105FJR Lmbe family HUB98_RS04835 ENOG4108Z5K methylglyoxal synthase HUB98_RS04840 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUB98_RS04850 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HUB98_RS04855 ENOG4108JYZ YitT family HUB98_RS04875 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUB98_RS04880 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HUB98_RS04895 ENOG4108Z0R Transferase HUB98_RS04905 ENOG4105CVJ phosphoglycerate mutase HUB98_RS04915 ENOG4105EMN RNA polymerase sigma factor HUB98_RS04925 ENOG4105CIH Imidazole acetol-phosphate transaminase HUB98_RS04930 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUB98_RS04940 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HUB98_RS04945 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUB98_RS04950 ENOG4108I0Q anthranilate phosphoribosyltransferase HUB98_RS04960 ENOG4105KHN chorismate mutase HUB98_RS04965 ENOG4105D49 3-dehydroquinate synthase HUB98_RS04970 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUB98_RS04975 ENOG4105BZU Histidine kinase HUB98_RS04980 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUB98_RS04990 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUB98_RS04995 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HUB98_RS05000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUB98_RS05015 ENOG4105WP2 Tryptophan RNA-binding attenuator protein HUB98_RS05025 ENOG4105K70 DNA-binding protein HUB98_RS05030 ENOG4108HWV )-transporter HUB98_RS05035 ENOG4105C2J ABC transporter HUB98_RS05045 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HUB98_RS05075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUB98_RS05080 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HUB98_RS05085 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUB98_RS05090 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUB98_RS05095 ENOG4105F6E Acyl-transferase HUB98_RS05100 ENOG4105CAT Cytidine monophosphate kinase HUB98_RS05115 ENOG4105MSI germination protein ypeb HUB98_RS05125 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HUB98_RS05130 ENOG4108S6Z Negative regulator of genetic competence HUB98_RS05140 ENOG4107RGJ metallophosphoesterase HUB98_RS05155 ENOG4108JQ1 Dehydrogenase HUB98_RS05165 ENOG4105BZU Histidine kinase HUB98_RS05170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS05175 ENOG4105CRE cytochrome C HUB98_RS05180 ENOG4107TWT Cytochrome c biogenesis protein HUB98_RS05185 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUB98_RS05190 ENOG4105FE9 pseudouridine synthase HUB98_RS05195 ENOG4105C0H protease HUB98_RS05205 ENOG4108JIC nucleoside recognition domain protein HUB98_RS05210 ENOG4105DZ1 carboxypeptidase HUB98_RS05215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUB98_RS05220 ENOG4105E4C Lytic transglycosylase catalytic HUB98_RS05375 ENOG4107EF8 Glycosyl transferase (Group 1 HUB98_RS05405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HUB98_RS05410 ENOG4105XSJ toxin secretion phage lysis holin HUB98_RS05415 ENOG4105KBJ sporulation protein ytfj HUB98_RS05435 ENOG4105C0B DNA polymerase III (alpha subunit) HUB98_RS05440 ENOG4106F1P AAA ATPase, central domain protein HUB98_RS05525 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUB98_RS05530 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUB98_RS05545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUB98_RS05550 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUB98_RS05725 ENOG4108J9Q DNA ligase HUB98_RS05830 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUB98_RS05845 ENOG4105GJD protein, conserved in bacteria HUB98_RS06045 ENOG4108VCI transcription factor, rsfa family HUB98_RS06140 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUB98_RS06265 ENOG4107QYX exodeoxyribonuclease v alpha HUB98_RS06280 ENOG4105ZUG HUB98_RS06410 ENOG4105E4C Lytic transglycosylase catalytic HUB98_RS06420 ENOG4105E4C Lytic transglycosylase catalytic HUB98_RS06565 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUB98_RS06575 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUB98_RS06580 ENOG4108R6K riboflavin synthase, subunit alpha HUB98_RS06585 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HUB98_RS06595 ENOG4107ZE5 PPIases accelerate the folding of proteins HUB98_RS06600 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUB98_RS06625 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUB98_RS06640 ENOG4105DZ1 carboxypeptidase HUB98_RS06650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUB98_RS06660 ENOG4105I3K Ferric uptake regulator, Fur family HUB98_RS06665 ENOG4105MZ9 stage II sporulation protein m HUB98_RS06675 ENOG4108YZ4 nudix hydrolase HUB98_RS06685 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HUB98_RS06695 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUB98_RS06700 ENOG4105C7S Dehydrogenase HUB98_RS06705 ENOG4105CPP Dehydrogenase, E1 component HUB98_RS06720 ENOG4106CCJ Protein of unknown function (DUF2627) HUB98_RS06750 ENOG4105CAY ferredoxin--nadp reductase HUB98_RS06760 ENOG4107QQR Sporulation HUB98_RS06765 ENOG4105S1Z Stage IV sporulation protein B HUB98_RS06770 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUB98_RS06775 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUB98_RS06785 ENOG4105DX0 Hemolysin A HUB98_RS06790 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUB98_RS06800 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUB98_RS06805 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUB98_RS06810 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUB98_RS06830 ENOG4108ZSR alkaline shock protein HUB98_RS06835 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUB98_RS06855 ENOG410644B Stage III sporulation protein af HUB98_RS06865 ENOG4105KQ4 Stage iii sporulation protein ad HUB98_RS06870 ENOG4108CQH stage III sporulation protein AC HUB98_RS06875 ENOG4105KR5 Stage iii sporulation protein HUB98_RS06880 ENOG4105CD2 stage iii sporulation protein aa HUB98_RS06890 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUB98_RS06895 ENOG4105DC7 peptidase M24 HUB98_RS06900 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUB98_RS06910 ENOG4105CBJ Metal-dependent enzyme HUB98_RS06925 ENOG4105F32 YngK protein HUB98_RS06930 ENOG4105KST dependent repressor HUB98_RS06935 ENOG4105F6S Spore photoproduct lyase HUB98_RS06940 ENOG4107QIV Cytochrome c biogenesis protein HUB98_RS06950 ENOG4105FDK ABC transporter HUB98_RS06960 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUB98_RS06965 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUB98_RS06970 ENOG4105N80 Ferric uptake regulator, Fur family HUB98_RS06980 ENOG4105F1A Pyruvate formate-lyase HUB98_RS06985 ENOG4105C6N Formate acetyltransferase HUB98_RS06995 ENOG4105C0A alcohol dehydrogenase HUB98_RS07000 ENOG4107V6Q Cyclic nucleotide-binding domain HUB98_RS07045 ENOG4105EP9 oxidoreductase HUB98_RS07055 ENOG4105E0X reductase HUB98_RS07065 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HUB98_RS07070 ENOG4108JYZ YitT family HUB98_RS07090 ENOG4105C6T cysteine synthase HUB98_RS07095 ENOG4105DVT helicase HUB98_RS07100 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding HUB98_RS07130 ENOG4105D1Q UPF0246 protein HUB98_RS07245 ENOG4105F9F transposase HUB98_RS07270 ENOG41079KZ Major Facilitator Superfamily HUB98_RS07275 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUB98_RS07280 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUB98_RS07285 ENOG4107YY3 extracellular solute-binding protein family 1 HUB98_RS07290 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUB98_RS07295 ENOG4105FTV AraC Family Transcriptional Regulator HUB98_RS07315 ENOG4107QQG Dehydrogenase HUB98_RS07320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS07325 ENOG4105CND Glycosyl transferase, family 2 HUB98_RS07340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUB98_RS07350 ENOG4105CSV Glutaminase HUB98_RS07360 ENOG4105KNA -acetyltransferase HUB98_RS07365 ENOG4105FCD Major Facilitator HUB98_RS07370 ENOG4105DY9 regulatoR HUB98_RS07375 ENOG4108HRK Histidine kinase HUB98_RS07400 ENOG4105C2F Histidine kinase HUB98_RS07410 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUB98_RS07420 ENOG4105CB5 ATP-dependent DNA helicase recG HUB98_RS07425 ENOG4105EPR degv family HUB98_RS07430 ENOG4105DP4 dak2 domain fusion protein ylov HUB98_RS07440 ENOG4105VB9 50S ribosomal protein l28 HUB98_RS07460 ENOG4105DJV ribulose-phosphate 3-epimerase HUB98_RS07465 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUB98_RS07470 ENOG4105D9P serine threonine protein kinase HUB98_RS07475 ENOG4108ZF3 Phosphatase HUB98_RS07480 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUB98_RS07485 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HUB98_RS07490 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUB98_RS07495 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUB98_RS07500 ENOG4105C25 Primosomal protein n' HUB98_RS07505 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HUB98_RS07510 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUB98_RS07515 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUB98_RS07520 ENOG4105KC4 UPF0296 protein HUB98_RS07525 ENOG4105DSJ YicC domain protein HUB98_RS07565 ENOG4105WUC UPF0298 protein HUB98_RS07595 ENOG4105CNI cell division protein FtsW HUB98_RS07600 ENOG4105VBF alkaline shock protein HUB98_RS07605 ENOG4105UPD Calcium Proton HUB98_RS07610 ENOG4105ZPI UPF0358 protein HUB98_RS07620 ENOG4105C88 aminopeptidase HUB98_RS07630 ENOG4105BZU Histidine kinase HUB98_RS07635 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUB98_RS07655 ENOG4105F1V Acetoin utilization protein HUB98_RS07660 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUB98_RS07665 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS07680 ENOG4107RKG DJ-1/PfpI family HUB98_RS07685 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUB98_RS07690 ENOG4105CI1 PTS System HUB98_RS07695 ENOG4105K4P CoA-binding domain protein HUB98_RS07700 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUB98_RS07705 ENOG41085GJ domain protein HUB98_RS07710 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUB98_RS07715 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUB98_RS07735 ENOG4105CXN decarboxylase HUB98_RS07740 ENOG41068XD UPF0473 protein HUB98_RS07760 ENOG4108ZHJ Organic hydroperoxide resistance protein HUB98_RS07780 ENOG41082BV acetyltransferase HUB98_RS07810 ENOG4105WEF catalase HUB98_RS07820 ENOG4105BZ1 (ABC) transporter HUB98_RS07825 ENOG4105EHG Permease protein HUB98_RS07830 ENOG4105DQ5 transport system permease protein HUB98_RS07835 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUB98_RS07845 ENOG4108URH decarboxylase HUB98_RS07855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUB98_RS07860 ENOG4105C87 Aminotransferase class I and II HUB98_RS07900 ENOG4105WFK nuclease HUB98_RS07905 ENOG4105BZU Histidine kinase HUB98_RS07965 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUB98_RS07975 ENOG4105DJY efflux transporter, rnd family, mfp subunit HUB98_RS07980 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUB98_RS08005 ENOG4105CD3 dihydroorotase HUB98_RS08010 ENOG4105CXT aspartate transcarbamylase HUB98_RS08015 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUB98_RS08050 ENOG4105CHM Aminotransferase HUB98_RS08055 ENOG4105C34 Pseudouridine synthase HUB98_RS08060 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUB98_RS08075 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUB98_RS08085 ENOG4105DBK s4 domain protein HUB98_RS08090 ENOG41067XK integral membrane protein HUB98_RS08095 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUB98_RS08100 ENOG4105DFA alanine racemase domain protein HUB98_RS08105 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUB98_RS08110 ENOG4105WR5 sporulation protein, YlmC YmxH family HUB98_RS08120 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUB98_RS08125 ENOG4105FFI sigma-e processing peptidase spoiiga HUB98_RS08130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUB98_RS08135 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HUB98_RS08140 ENOG41087KY Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HUB98_RS08145 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUB98_RS08150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUB98_RS08155 ENOG4105CNI cell division protein FtsW HUB98_RS08160 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUB98_RS08170 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HUB98_RS08175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUB98_RS08180 ENOG4105CJN penicillin-binding protein HUB98_RS08185 ENOG4105CJN penicillin-binding protein HUB98_RS08195 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUB98_RS08200 ENOG4108V6E Cell division protein mraZ HUB98_RS08205 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUB98_RS08210 ENOG41074B2 UPF0747 protein HUB98_RS08215 ENOG4108JQ6 ABC transporter HUB98_RS08220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS08225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS08230 ENOG4108J59 Extracellular solute-binding protein, family 5 HUB98_RS08240 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUB98_RS08245 ENOG4108VCI transcription factor, rsfa family HUB98_RS08270 ENOG4108IAB Phoh family HUB98_RS08285 ENOG4108KGH TRANSCRIPTIONal HUB98_RS08295 ENOG4105CI3 gtp-binding protein typa HUB98_RS08305 ENOG4108ZCF integral membrane protein HUB98_RS08310 ENOG4108ZCF integral membrane protein HUB98_RS08315 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HUB98_RS08325 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HUB98_RS08355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS08360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS08370 ENOG4105EGD dinuclear metal center protein, YbgI family HUB98_RS08385 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUB98_RS08395 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HUB98_RS08400 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HUB98_RS08410 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) HUB98_RS08420 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUB98_RS08430 ENOG4107YR5 Diacylglycerol kinase HUB98_RS08435 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUB98_RS08440 ENOG4105CTJ Metal Dependent Phosphohydrolase HUB98_RS08445 ENOG4105C9A Phoh family HUB98_RS08455 ENOG41068P3 sporulation protein YqfC HUB98_RS08465 ENOG4105DI5 UPF0365 protein HUB98_RS08470 ENOG4105F7J membrane-bound serine protease HUB98_RS08475 ENOG4105KTH gatB Yqey HUB98_RS08480 ENOG4105VCC 30S ribosomal protein S21 HUB98_RS08485 ENOG4107YU2 histidine triad (hIT) protein HUB98_RS08495 ENOG4105EYH Exonuclease HUB98_RS08505 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HUB98_RS08525 ENOG41062IR nudix hydrolase HUB98_RS08530 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUB98_RS08535 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HUB98_RS08540 ENOG4108Z4T Peptidase M50 HUB98_RS08545 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUB98_RS08570 ENOG4105CFG Acts as a chaperone (By similarity) HUB98_RS08580 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUB98_RS08585 ENOG4105BZU Histidine kinase HUB98_RS08590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS08605 ENOG4105CSA Coproporphyrinogen iii oxidase HUB98_RS08610 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUB98_RS08630 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUB98_RS08635 ENOG4105TQK DNA polymerase iii, delta' subunit HUB98_RS08645 ENOG4105EMN RNA polymerase sigma factor HUB98_RS08655 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HUB98_RS08665 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HUB98_RS08675 ENOG4105C8T Leucyl-tRNA synthetase HUB98_RS08685 ENOG4108D32 Methyltransferase HUB98_RS08690 ENOG4105QNR S1 RNA binding domain protein HUB98_RS08700 ENOG4108WF2 Metal Dependent Phosphohydrolase HUB98_RS08705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUB98_RS08710 ENOG410812S Rna-binding protein HUB98_RS08715 ENOG4105E2X shikimate dehydrogenase HUB98_RS08720 ENOG4105CQW ribosome biogenesis GTPase YqeH HUB98_RS08725 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HUB98_RS08740 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUB98_RS08750 ENOG4105CZ3 stage V sporulation protein ad HUB98_RS08755 ENOG41090VF Stage v sporulation protein ac HUB98_RS08775 ENOG4108IFG nitrite reductase, (NAD(P)H) HUB98_RS08780 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HUB98_RS08785 ENOG4107V9H nitrite transporter HUB98_RS08795 ENOG4107Y80 Major Facilitator superfamily HUB98_RS08805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUB98_RS08840 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUB98_RS08845 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUB98_RS08850 ENOG4105C1G acyl-Coa dehydrogenase HUB98_RS08885 ENOG4105D9P serine threonine protein kinase HUB98_RS08890 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HUB98_RS08895 ENOG4108B1Q Ribonuclease HUB98_RS08900 ENOG410900G Protein of unknown function (DUF421) HUB98_RS08905 ENOG4105E0A ABC, transporter HUB98_RS08910 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) HUB98_RS08920 ENOG4105K56 Transcriptional regulator HUB98_RS08930 ENOG4105C85 amino acid HUB98_RS08965 ENOG4105F9F transposase HUB98_RS09105 ENOG4108MDF Phage Portal Protein HUB98_RS09175 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUB98_RS09200 ENOG4105QBX endodeoxyribonuclease RusA HUB98_RS09215 ENOG4105CDU Replicative dna helicase HUB98_RS09355 ENOG4105F27 Major Facilitator HUB98_RS09360 ENOG41065RQ ADP-ribosylation crystallin J1 HUB98_RS09365 ENOG4107YBY Hydrolase HUB98_RS09370 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HUB98_RS09540 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUB98_RS09545 ENOG4105CHM Aminotransferase HUB98_RS09565 ENOG4105BZU Histidine kinase HUB98_RS09570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS09575 ENOG4105C5Y PTS System HUB98_RS09580 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HUB98_RS09595 ENOG4108RF1 Protein of unknown function DUF2625 HUB98_RS09600 ENOG4108M26 parallel beta-helix repeat protein HUB98_RS09620 ENOG4108Z5V transcriptional regulator, merr family HUB98_RS09635 ENOG4105EBR Carboxylesterase HUB98_RS09640 ENOG4105G6Z alkaline phosphatase HUB98_RS09645 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUB98_RS09660 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS09665 ENOG4107SDU Methyl-accepting chemotaxis HUB98_RS09670 ENOG4108NR7 pectate lyase HUB98_RS09700 ENOG4105C5Y PTS System HUB98_RS09705 ENOG4105CID antiterminator HUB98_RS09715 ENOG4105CS2 ec 3.2.1.21 HUB98_RS09735 ENOG4108JQ6 ABC transporter HUB98_RS09745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS09760 ENOG4108YQE rare lipoprotein a HUB98_RS09765 ENOG4107S91 Sodium hydrogen exchanger HUB98_RS09770 ENOG4105NCW Trka-c domain protein HUB98_RS09780 ENOG4107R37 Glutamate dehydrogenase HUB98_RS09790 ENOG4105DDN Pentapeptide repeat-containing protein HUB98_RS09810 ENOG4105CGK Exodeoxyribonuclease III HUB98_RS09825 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUB98_RS09840 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUB98_RS09845 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUB98_RS09855 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS09870 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUB98_RS09885 ENOG4107T5V SNARE associated Golgi HUB98_RS09920 ENOG4105CFG Acts as a chaperone (By similarity) HUB98_RS09955 ENOG4105CZ9 Domain of unknown function (DU1801) HUB98_RS09965 ENOG4105D29 Helix-turn-helix type 11 domain protein HUB98_RS09970 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS09975 ENOG4105E2Z phosphate ABC transporter (Permease HUB98_RS09980 ENOG4105C8U phosphate abc transporter HUB98_RS09995 ENOG4108NEV two component transcriptional regulator, LytTR family HUB98_RS10025 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS10040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUB98_RS10045 ENOG4105C2F Histidine kinase HUB98_RS10050 ENOG4105EQD regulatoR HUB98_RS10095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUB98_RS10120 ENOG4105DZC cytosine deaminase HUB98_RS10135 ENOG4105CJW magnesium transporter HUB98_RS10140 ENOG4108HWW ABC transporter HUB98_RS10150 ENOG4105DFW ABC transporter HUB98_RS10155 ENOG4105EQD regulatoR HUB98_RS10160 ENOG4105C2F Histidine kinase HUB98_RS10180 ENOG410841Q phosphoesterase PA-phosphatase related protein HUB98_RS10185 ENOG4105CS2 ec 3.2.1.21 HUB98_RS10190 ENOG4105D29 Helix-turn-helix type 11 domain protein HUB98_RS10220 ENOG4105RKW reductase (By HUB98_RS10240 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUB98_RS10250 ENOG4105JD4 ATPase yjob HUB98_RS10260 ENOG4107TS3 membrane protein, TerC HUB98_RS10265 ENOG4105VCH membrane HUB98_RS10270 ENOG4107SBE Glycosyl transferase (Group 1 HUB98_RS10290 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUB98_RS10295 ENOG4108IUM Glycogen debranching enzyme HUB98_RS10300 ENOG4108IUM Glycogen debranching enzyme HUB98_RS10305 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS10310 ENOG4105F5H Glycosyl Hydrolase Family 88 HUB98_RS10315 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS10320 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS10330 ENOG41075H3 AraC family transcriptional regulator HUB98_RS10340 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HUB98_RS10350 ENOG4105ETD TRANSCRIPTIONal HUB98_RS10360 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUB98_RS10365 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUB98_RS10370 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUB98_RS10375 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUB98_RS10395 ENOG4105CID antiterminator HUB98_RS10400 ENOG4105DZ6 Band 7 protein HUB98_RS10410 ENOG4107QW4 alcohol dehydrogenase HUB98_RS10420 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HUB98_RS10425 ENOG4105CMR udp-glucose 4-epimerase HUB98_RS10430 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUB98_RS10440 ENOG4105CPC Aldo Keto reductase HUB98_RS10445 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUB98_RS10450 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HUB98_RS10460 ENOG4108UHU Aldolase HUB98_RS10465 ENOG4105D7K pfkb domain protein HUB98_RS10470 ENOG4108TGC Acyltransferase HUB98_RS10480 ENOG4105C01 Dihydroxy-acid dehydratase HUB98_RS10495 ENOG4107XRG penicillin-binding protein HUB98_RS10500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUB98_RS10505 ENOG4105CFP Peptidase U32 HUB98_RS10510 ENOG4105XYU peptidase (U32 family) HUB98_RS10515 ENOG4105HHA aminodeoxychorismate lyase HUB98_RS10525 ENOG4105VPH UPF0473 protein HUB98_RS10540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUB98_RS10545 ENOG4105C02 permease HUB98_RS10550 ENOG41060CR HUB98_RS10560 ENOG4105C3J Cysteine desulfurase HUB98_RS10570 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUB98_RS10575 ENOG41083TI Protein CrcB homolog HUB98_RS10580 ENOG4105WMR Protein CrcB homolog HUB98_RS10585 ENOG4105D1H recombination factor protein RarA HUB98_RS10590 ENOG4105EGI Transcriptional regulator HUB98_RS10605 ENOG4105EEM helicase HUB98_RS10610 ENOG4105BZ1 (ABC) transporter HUB98_RS10620 ENOG4105CUZ uba thif-type nad fad binding protein HUB98_RS10625 ENOG4105C9M aspartyl-trna synthetase HUB98_RS10630 ENOG4105CUT histidyl-tRNA synthetase HUB98_RS10640 ENOG4107R7Y intracellular protease Pfpi family HUB98_RS10650 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUB98_RS10655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUB98_RS10665 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUB98_RS10670 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HUB98_RS10680 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUB98_RS10685 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUB98_RS10695 ENOG4105CKP Polysaccharide Biosynthesis Protein HUB98_RS10700 ENOG4108QG2 Membrane HUB98_RS10710 ENOG4105VIE preprotein translocase, subunit YajC HUB98_RS10725 ENOG4105JFG SpoIID LytB domain protein HUB98_RS10730 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUB98_RS10735 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUB98_RS10740 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUB98_RS10815 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUB98_RS10820 ENOG4105CQC Prephenate dehydratase HUB98_RS10825 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUB98_RS10830 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUB98_RS10835 ENOG4105D6E homoserine dehydrogenase HUB98_RS10840 ENOG41090I5 UPF0735 ACT domain-containing protein HUB98_RS10845 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUB98_RS10855 ENOG4105K46 50S ribosomal protein l27 HUB98_RS10860 ENOG4105X36 (ribosomal) protein HUB98_RS10865 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUB98_RS10870 ENOG4105C03 ribonuclease HUB98_RS10885 ENOG4107QMS site-determining protein HUB98_RS10890 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HUB98_RS10905 ENOG4105DFF Rod shape-determining protein mreb HUB98_RS10910 ENOG4105W5Q DNA repair protein (RadC HUB98_RS10915 ENOG4108Z03 MAF-like protein HUB98_RS10930 ENOG4105DFU Cell wall formation (By similarity) HUB98_RS10940 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUB98_RS10945 ENOG41068KH stage VI sporulation protein D HUB98_RS10950 ENOG4108YBP pseudouridine synthase HUB98_RS10955 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUB98_RS10960 ENOG4105D52 delta-aminolevulinic acid dehydratase HUB98_RS10975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUB98_RS10990 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HUB98_RS11000 ENOG4108IUQ atp-dependent protease HUB98_RS11005 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUB98_RS11010 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUB98_RS11020 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUB98_RS11035 ENOG4105DJ2 Major Facilitator Superfamily HUB98_RS11040 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HUB98_RS11045 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUB98_RS11070 ENOG4105CAQ asparagine synthetase HUB98_RS11075 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS11085 ENOG4105D4P Coproporphyrinogen iii oxidase HUB98_RS11105 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUB98_RS11110 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUB98_RS11115 ENOG4108XJQ germination protein HUB98_RS11120 ENOG4108W5N phosphatidylglycerophosphatase a HUB98_RS11140 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUB98_RS11150 ENOG4105I3N Conserved Protein HUB98_RS11155 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUB98_RS11180 ENOG4105CE4 GlcNAc 6-P deacetylase HUB98_RS11190 ENOG4106KNT transcriptional regulator HUB98_RS11195 ENOG4105PFC Transcriptional regulator HUB98_RS11220 ENOG4105CJ1 ABC, transporter HUB98_RS11230 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUB98_RS11240 ENOG4107T8Q Glycosyl transferase (Group 1 HUB98_RS11255 ENOG4105KNA -acetyltransferase HUB98_RS11260 ENOG4105K64 Glycosyl transferase, family 2 HUB98_RS11270 ENOG4105K64 Glycosyl transferase, family 2 HUB98_RS11275 ENOG4108SMP Nad-dependent epimerase dehydratase HUB98_RS11285 ENOG4105C5E polysaccharide biosynthesis protein HUB98_RS11290 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUB98_RS11330 ENOG4105CDA abc transporter atp-binding protein HUB98_RS11355 ENOG4105E0C molybdate abc transporter HUB98_RS11360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HUB98_RS11365 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HUB98_RS11375 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUB98_RS11380 ENOG4105CKI cobalamin synthesis protein HUB98_RS11395 ENOG4108S9F abc transporter, atp-binding protein HUB98_RS11400 ENOG4108RZA ABC transporter HUB98_RS11405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS11410 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS11415 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUB98_RS11440 ENOG4105DEN Luciferase family HUB98_RS11500 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HUB98_RS11515 ENOG4105CKK Glycosyl transferase, family 2 HUB98_RS11520 ENOG4105D4Y metalloprotease HUB98_RS11535 ENOG4105DJ4 phosphatidylserine decarboxylase HUB98_RS11540 ENOG4108R6W Transcriptional regulator, ARAC family HUB98_RS11575 ENOG4108IXY short-chain dehydrogenase reductase HUB98_RS11585 ENOG4105DND Transcriptional regulator HUB98_RS11590 ENOG4107RVV histidinol phosphate phosphatase, hisj family HUB98_RS11595 ENOG4105KNA -acetyltransferase HUB98_RS11610 ENOG4105E33 succinate dehydrogenase HUB98_RS11620 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HUB98_RS11625 ENOG4105F04 LysR family Transcriptional regulator HUB98_RS11630 ENOG4107ZYR domain protein HUB98_RS11635 ENOG4105CZN Potassium uptake protein HUB98_RS11645 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUB98_RS11650 ENOG4105K63 Thioredoxin HUB98_RS11665 ENOG4105C8I hydrolase, family 38 HUB98_RS11685 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUB98_RS11690 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS11705 ENOG4105EQD regulatoR HUB98_RS11710 ENOG4105C2F Histidine kinase HUB98_RS11725 ENOG4107JTW chlorite dismutase HUB98_RS11735 ENOG4105CEP NADH dehydrogenase HUB98_RS11755 ENOG410839P HUB98_RS11765 ENOG4105D49 3-dehydroquinate synthase HUB98_RS11770 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUB98_RS11800 ENOG4105FR1 rard protein HUB98_RS11805 ENOG4108RYK Nad-dependent epimerase dehydratase HUB98_RS11810 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HUB98_RS11815 ENOG4105DVY radical SAM domain protein HUB98_RS11830 ENOG41083MR nifu domain-containing protein HUB98_RS11845 ENOG4105D01 (LipO)protein HUB98_RS11850 ENOG4108UMI ABC transporter, permease HUB98_RS11855 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS11865 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HUB98_RS11895 ENOG4105CC5 ABC transporter HUB98_RS11900 ENOG4105CC5 ABC transporter HUB98_RS11905 ENOG4105DIK (ABC) transporter HUB98_RS11910 ENOG4105DSE periplasmic solute binding protein HUB98_RS11915 ENOG4107RF6 penicillin-binding protein HUB98_RS11920 ENOG4107RF6 penicillin-binding protein HUB98_RS11950 ENOG41067AE Membrane-bound metal-dependent hydrolase HUB98_RS11965 ENOG4105C31 Tryptophanyl-tRNA synthetase HUB98_RS12005 ENOG4108Z18 K06886 hemoglobin HUB98_RS12010 ENOG4105H20 Sporulation integral membrane protein YlbJ HUB98_RS12015 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUB98_RS12020 ENOG4105MMD transcriptional regulator HUB98_RS12030 ENOG4105FAA peptidase M23 HUB98_RS12045 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUB98_RS12050 ENOG4105KVH Transcriptional regulator HUB98_RS12075 ENOG4106AKK s-layer domain-containing protein HUB98_RS12100 ENOG4106AKK s-layer domain-containing protein HUB98_RS12135 ENOG4105CNA YD repeat protein HUB98_RS12145 ENOG4105CNA YD repeat protein HUB98_RS12170 ENOG4105CNA YD repeat protein HUB98_RS12210 ENOG4105EC2 ftsk spoIIIe HUB98_RS12285 ENOG4108RWN rrna methyltransferase HUB98_RS12290 ENOG4107ZYR domain protein HUB98_RS12300 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HUB98_RS12305 ENOG4108VGI doxx family HUB98_RS12310 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUB98_RS12320 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS12325 ENOG4105ENE Histidine kinase HUB98_RS12335 ENOG41087YS Phage shock protein A HUB98_RS12360 ENOG41075H3 AraC family transcriptional regulator HUB98_RS12365 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUB98_RS12380 ENOG4105K6V RNA polymerase HUB98_RS12480 ENOG4105TUA UPF0295 protein HUB98_RS12490 ENOG4105G5W regulator Fur family HUB98_RS12505 ENOG4105KT7 mgtC SapB transporter HUB98_RS12510 ENOG4105RHY Pfam:UPF0157 HUB98_RS12515 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUB98_RS12520 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUB98_RS12525 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUB98_RS12550 ENOG4105C5X domain protein HUB98_RS12560 ENOG4107T5V SNARE associated Golgi HUB98_RS12590 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUB98_RS12595 ENOG4108ZDA Sporulation protein YyaC HUB98_RS12610 ENOG4105YVM Phosphoesterase, PA-phosphatase related HUB98_RS12635 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUB98_RS12640 ENOG4105WN5 stage II sporulation protein HUB98_RS12645 ENOG4105BZU Histidine kinase HUB98_RS12650 ENOG4105BZU Histidine kinase HUB98_RS12655 ENOG4105BZU Histidine kinase HUB98_RS12660 ENOG4108MJI response regulator HUB98_RS12700 ENOG4105C5H ABC transporter HUB98_RS12720 ENOG4105BZU Histidine kinase HUB98_RS12725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS12740 ENOG4108IQI permease HUB98_RS12755 ENOG4106P55 Transcriptional regulator HUB98_RS12760 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUB98_RS12775 ENOG4105NTD Inherit from COG: Hydrolase HUB98_RS12780 ENOG4108RTU Aldolase HUB98_RS12785 ENOG4107TVC Glycosyl transferase, family 2 HUB98_RS12790 ENOG4106WTF Glycosyl transferase, family 2 HUB98_RS12795 ENOG4105CMG Carbohydrate kinase HUB98_RS12800 ENOG4105C93 Xylose Isomerase HUB98_RS12820 ENOG4105C3M thioredoxin reductase HUB98_RS12830 ENOG4107S9D Alpha beta hydrolase HUB98_RS12835 ENOG4105C59 p-type ATPase HUB98_RS12855 ENOG4105CHR reductase HUB98_RS12860 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS12865 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) HUB98_RS12875 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HUB98_RS12885 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUB98_RS12890 ENOG4105E2S oxidase) subunit II HUB98_RS12900 ENOG4105CS2 ec 3.2.1.21 HUB98_RS12920 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS12935 ENOG4105C2F Histidine kinase HUB98_RS12945 ENOG4105CDA abc transporter atp-binding protein HUB98_RS12950 ENOG4105E5Q amino acid AbC transporter HUB98_RS12955 ENOG4105EAB amino acid AbC transporter HUB98_RS12960 ENOG4105PF9 Transcriptional regulator HUB98_RS12965 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUB98_RS12980 ENOG4105SZ6 Thioredoxin HUB98_RS12985 ENOG4105CPC Aldo Keto reductase HUB98_RS12995 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUB98_RS13000 ENOG4108SJC Membrane HUB98_RS13005 ENOG4107RWR Sodium hydrogen exchanger HUB98_RS13015 ENOG4107ZTW SNARE associated Golgi HUB98_RS13020 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HUB98_RS13025 ENOG4105BZU Histidine kinase HUB98_RS13030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS13035 ENOG4105DWF phosphomethylpyrimidine kinase HUB98_RS13040 ENOG4105EPR degv family HUB98_RS13055 ENOG4105CJ1 ABC, transporter HUB98_RS13125 ENOG4105YVS arsR family transcriptional regulator HUB98_RS13155 ENOG4108FN7 Aldo keto reductase HUB98_RS13180 ENOG4108J5H Homocysteine s-methyltransferase HUB98_RS13185 ENOG4108IQI permease HUB98_RS13190 ENOG4108NHD germination protein HUB98_RS13195 ENOG4108Q8B Spore germination protein HUB98_RS13205 ENOG4107SDU Methyl-accepting chemotaxis HUB98_RS13220 ENOG4105BZ1 (ABC) transporter HUB98_RS13225 ENOG4105BZ1 (ABC) transporter HUB98_RS13245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUB98_RS13255 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUB98_RS13265 ENOG4105C8B TIGR00159 family HUB98_RS13275 ENOG4105EMN RNA polymerase sigma factor HUB98_RS13280 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUB98_RS13345 ENOG4105PNS DnaD domain protein HUB98_RS13370 ENOG4108IMY Transcriptional regulator HUB98_RS13375 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HUB98_RS13480 ENOG4108NMV polysaccharide deacetylase HUB98_RS13495 ENOG4105D1F ATP-binding protein HUB98_RS13505 ENOG4107S4M Sulfate adenylate transferase HUB98_RS13510 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUB98_RS13515 ENOG4108UJD 30S ribosomal protein S9 HUB98_RS13520 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUB98_RS13525 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUB98_RS13530 ENOG4108ZT0 50S ribosomal protein l17 HUB98_RS13535 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUB98_RS13540 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUB98_RS13545 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUB98_RS13550 ENOG41067V7 50S ribosomal protein L36 HUB98_RS13555 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUB98_RS13565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUB98_RS13570 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUB98_RS13575 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUB98_RS13580 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUB98_RS13585 ENOG4105VPB 50S ribosomal protein L30 HUB98_RS13590 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUB98_RS13595 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUB98_RS13600 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUB98_RS13605 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUB98_RS13610 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUB98_RS13615 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUB98_RS13620 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUB98_RS13625 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUB98_RS13630 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUB98_RS13635 ENOG41082SA 50s ribosomal protein l29 HUB98_RS13640 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUB98_RS13645 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUB98_RS13650 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUB98_RS13655 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUB98_RS13660 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUB98_RS13665 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUB98_RS13670 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUB98_RS13675 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUB98_RS13680 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUB98_RS13685 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUB98_RS13690 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUB98_RS13695 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUB98_RS13700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUB98_RS13705 ENOG4105XPM ribosomal protein HUB98_RS13710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUB98_RS13715 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUB98_RS13720 ENOG4107Y49 methyltransferase HUB98_RS13725 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUB98_RS13730 ENOG4108VZM 50s ribosomal protein L10 HUB98_RS13735 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUB98_RS13740 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUB98_RS13745 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUB98_RS13750 ENOG410683Z Preprotein translocase SecE subunit HUB98_RS13755 ENOG4105WDJ 50S ribosomal protein L33 HUB98_RS13760 ENOG4105QIV RNA polymerase HUB98_RS13765 ENOG4105M0M Tetracycline resistance protein HUB98_RS13770 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUB98_RS13775 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HUB98_RS13780 ENOG4105C8N cysteinyl-tRNA synthetase HUB98_RS13785 ENOG4105D7W serine acetyltransferase HUB98_RS13790 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUB98_RS13795 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUB98_RS13800 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUB98_RS13805 ENOG4105CTP PilT protein domain protein HUB98_RS13815 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HUB98_RS13820 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUB98_RS13825 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUB98_RS13835 ENOG41066A3 ATP guanido phosphotransferase HUB98_RS13840 ENOG4108Z0C Uvrb UvrC protein HUB98_RS13880 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUB98_RS13885 ENOG4105C4R Atp-dependent dna helicase HUB98_RS13890 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HUB98_RS13900 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUB98_RS13910 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUB98_RS13915 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUB98_RS13920 ENOG4105C0D helicase HUB98_RS13925 ENOG4105CFP Peptidase U32 HUB98_RS13935 ENOG4105C0H protease HUB98_RS13945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUB98_RS13950 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUB98_RS13955 ENOG4105E14 MotA TolQ exbB proton channel HUB98_RS13960 ENOG4106VK6 Flagellar motor protein HUB98_RS13975 ENOG4105CJ1 ABC, transporter HUB98_RS13985 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS13995 ENOG4105CN1 protease HUB98_RS14000 ENOG4105DR5 peptidase HUB98_RS14005 ENOG4105CRP Part of the ABC transporter FtsEX involved in HUB98_RS14010 ENOG4105CAK Cell division ATP-binding protein ftsE HUB98_RS14015 ENOG41073R8 VanW family HUB98_RS14040 ENOG4105G9B Transcriptional regulator HUB98_RS14050 ENOG4105C5R Aminotransferase HUB98_RS14055 ENOG4105DTE Xanthine uracil vitamin C permease HUB98_RS14060 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUB98_RS14065 ENOG4105ERH Fumarylacetoacetate hydrolase HUB98_RS14075 ENOG4105CD3 dihydroorotase HUB98_RS14080 ENOG4105CH7 arginosuccinase HUB98_RS14085 ENOG4105CDH Citrulline--aspartate ligase HUB98_RS14090 ENOG4105DBV ornithine carbamoyltransferase HUB98_RS14100 ENOG4105CAS nag kinase HUB98_RS14105 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUB98_RS14110 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUB98_RS14115 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUB98_RS14130 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUB98_RS14135 ENOG4105MS2 ribosomal subunit Interface protein HUB98_RS14140 ENOG4105VEQ Cold shock protein HUB98_RS14150 ENOG4105MQ3 flagellar protein FliS HUB98_RS14155 ENOG4107RT6 flagellar hook-associated HUB98_RS14175 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HUB98_RS14180 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HUB98_RS14190 ENOG4105DTJ flagellar hook-associated protein HUB98_RS14195 ENOG4105E1Q flagellar hook-associated protein HUB98_RS14215 ENOG41081UC Inherit from COG: Competence protein HUB98_RS14240 ENOG4105BZU Histidine kinase HUB98_RS14255 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUB98_RS14275 ENOG4105HIR S-layer domain protein HUB98_RS14290 ENOG4105ESV Glycosyl transferase, family 4 HUB98_RS14315 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUB98_RS14325 ENOG4105CGA flagellar basal-body rod protein FlgG HUB98_RS14340 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HUB98_RS14345 ENOG4105FRN stage II sporulation protein HUB98_RS14355 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUB98_RS14360 ENOG4106778 Protein of unknown function (DUF1146) HUB98_RS14365 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUB98_RS14375 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUB98_RS14380 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUB98_RS14385 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUB98_RS14390 ENOG41083V9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUB98_RS14400 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HUB98_RS14415 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUB98_RS14420 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUB98_RS14425 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUB98_RS14430 ENOG4108UIC UPF0340 protein HUB98_RS14435 ENOG4107WAU Protein tyrosine phosphatase HUB98_RS14440 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HUB98_RS14445 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUB98_RS14450 ENOG4108ZXQ stage ii sporulation protein r HUB98_RS14460 ENOG4105CNI cell division protein FtsW HUB98_RS14465 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUB98_RS14470 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUB98_RS14475 ENOG4105C3G gtp-binding protein HUB98_RS14480 ENOG4105WQG acetyltransferase HUB98_RS14505 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUB98_RS14545 ENOG4107X2D transcriptional regulator, merr family HUB98_RS14560 ENOG410839T multidrug resistance protein HUB98_RS14565 ENOG41080TC multidrug resistance protein HUB98_RS14570 ENOG4108IG5 Transcriptional regulator HUB98_RS14595 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HUB98_RS14615 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUB98_RS14625 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUB98_RS14630 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HUB98_RS14640 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS14650 ENOG4105FKZ Methyl-accepting chemotaxis HUB98_RS14655 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HUB98_RS14660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS14665 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUB98_RS14695 ENOG4105CHR reductase HUB98_RS14700 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUB98_RS14705 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HUB98_RS14710 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 HUB98_RS14715 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS14720 ENOG410605W Major Facilitator HUB98_RS14725 ENOG4108J2R molybdopterin oxidoreductase HUB98_RS14730 ENOG4105TMB Formate nitrite transporter HUB98_RS14735 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUB98_RS14745 ENOG4108V06 Glutathione peroxidase HUB98_RS14755 ENOG4105E0A ABC, transporter HUB98_RS14810 ENOG4105C1J atp-dependent rna helicase HUB98_RS14825 ENOG4105CHH sulfate transporter HUB98_RS14855 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUB98_RS14860 ENOG4108P62 biosynthesis protein (CbiG) HUB98_RS14865 ENOG4105CIA precorrin-4 C(11)-methyltransferase HUB98_RS14870 ENOG4105DVK Precorrin-2 c20-methyltransferase HUB98_RS14875 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUB98_RS14880 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HUB98_RS14885 ENOG41081F0 Precorrin-8x methylmutase HUB98_RS14890 ENOG4108JTQ reductase HUB98_RS14900 ENOG4105E4R Precorrin-3B C17-methyltransferase HUB98_RS14905 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HUB98_RS14920 ENOG4108Q5U germination protein, ger(x)c family HUB98_RS14925 ENOG4105E1K spore germination protein HUB98_RS14945 ENOG4105D0M Protease HtpX homolog HUB98_RS14955 ENOG4105CH6 catalase HUB98_RS14960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS14975 ENOG4105CPC Aldo Keto reductase HUB98_RS14980 ENOG4105BZU Histidine kinase HUB98_RS14990 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HUB98_RS14995 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS15040 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUB98_RS15055 ENOG4108X0B nad(p)h dehydrogenase (quinone) HUB98_RS15070 ENOG4107RUE extracellular solute-binding protein family 1 HUB98_RS15075 ENOG4105D38 putrescine abc transporter HUB98_RS15080 ENOG4105F38 ABC transporter, permease HUB98_RS15085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS15105 ENOG4108RMU ferritin dps family protein HUB98_RS15115 ENOG4107SJW iron permease, FTR1 HUB98_RS15120 ENOG4105DBE peroxidase HUB98_RS15125 ENOG410650H (LipO)protein HUB98_RS15165 ENOG4105EYF MMPL domain protein HUB98_RS15175 ENOG4105KNA -acetyltransferase HUB98_RS15180 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HUB98_RS15190 ENOG4105BZ1 (ABC) transporter HUB98_RS15205 ENOG4105D2H Uronic isomerase HUB98_RS15210 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUB98_RS15225 ENOG4105DVT helicase HUB98_RS15230 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HUB98_RS15250 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HUB98_RS15255 ENOG4105CMU LysR family (Transcriptional regulator HUB98_RS15265 ENOG41067MG lrgb family HUB98_RS15270 ENOG4108M14 stage v sporulation protein t HUB98_RS15290 ENOG4105KVH Transcriptional regulator HUB98_RS15300 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUB98_RS15305 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUB98_RS15310 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HUB98_RS15315 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUB98_RS15325 ENOG4105YVS arsR family transcriptional regulator HUB98_RS15335 ENOG4105ESV Glycosyl transferase, family 4 HUB98_RS15355 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS15360 ENOG4108JJ8 (ABC) transporter HUB98_RS15365 ENOG4108JJ9 ABC, transporter HUB98_RS15370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUB98_RS15375 ENOG4105C4M (Ubiquinol oxidase) subunit I HUB98_RS15390 ENOG4107QPH glycogen) synthase HUB98_RS15400 ENOG4107TVC Glycosyl transferase, family 2 HUB98_RS15405 ENOG4107TVC Glycosyl transferase, family 2 HUB98_RS15465 ENOG4105C72 UPF0176 protein HUB98_RS15475 ENOG4105BZU Histidine kinase HUB98_RS15480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS15495 ENOG4105UQX Mate efflux family protein HUB98_RS15500 ENOG4105DRS transport system, permease HUB98_RS15515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HUB98_RS15520 ENOG4105C2F Histidine kinase HUB98_RS15535 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUB98_RS15565 ENOG4105C5H ABC transporter HUB98_RS15700 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS15710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS15715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS15720 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUB98_RS15735 ENOG4107RDP Dehydrogenase HUB98_RS15745 ENOG4105CJ1 ABC, transporter HUB98_RS15760 ENOG41062D9 Histidine kinase HUB98_RS15765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS15785 ENOG4108AEY RNA polymerase sigma factor HUB98_RS15840 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUB98_RS15845 ENOG4105DY9 regulatoR HUB98_RS15855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUB98_RS15860 ENOG41069HH 4-oxalocrotonate tautomerase HUB98_RS15865 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HUB98_RS15875 ENOG4105FKZ Methyl-accepting chemotaxis HUB98_RS15895 ENOG4105CX8 fg-gap repeat protein HUB98_RS15905 ENOG4108S4H thioesterase Superfamily protein HUB98_RS15930 ENOG4105XJC Two component transcriptional regulator (Winged helix family HUB98_RS15955 ENOG4108WZ2 response regulator HUB98_RS15975 ENOG4108I5G Major Facilitator superfamily HUB98_RS15980 ENOG4108RTU Aldolase HUB98_RS15990 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUB98_RS15995 ENOG4108KGH TRANSCRIPTIONal HUB98_RS16000 ENOG4105CPC Aldo Keto reductase HUB98_RS16005 ENOG4105RV9 Transcriptional regulator HUB98_RS16015 ENOG4105KVH Transcriptional regulator HUB98_RS16020 ENOG4105F27 Major Facilitator HUB98_RS16025 ENOG4105CV8 reductase HUB98_RS16040 ENOG4105F5H Glycosyl Hydrolase Family 88 HUB98_RS16045 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS16055 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS16065 ENOG4105DKW ABC transporter HUB98_RS16075 ENOG4107R8N Glycosyl transferase, family 2 HUB98_RS16095 ENOG4108U05 Transcriptional regulator HUB98_RS16100 ENOG41082BV acetyltransferase HUB98_RS16105 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUB98_RS16110 ENOG4105C8J )-transporter HUB98_RS16155 ENOG4105EMU Dehydrogenase HUB98_RS16170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUB98_RS16180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HUB98_RS16190 ENOG4105EBR Carboxylesterase HUB98_RS16200 ENOG410814C multidrug resistance protein HUB98_RS16205 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUB98_RS16220 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUB98_RS16225 ENOG4105TRT Transcriptional regulator HUB98_RS16245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUB98_RS16265 ENOG4108IJ6 ABC transporter HUB98_RS16285 ENOG4107QM2 Aldo Keto reductase HUB98_RS16300 ENOG4105CGH 5'-nucleotidase HUB98_RS16305 ENOG4105C1J atp-dependent rna helicase HUB98_RS16310 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUB98_RS16315 ENOG4105CHR reductase HUB98_RS16320 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUB98_RS16340 ENOG4107QMS site-determining protein HUB98_RS16345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS16360 ENOG4105D29 Helix-turn-helix type 11 domain protein HUB98_RS16375 ENOG4105NAE bifunctional deaminase-reductase domain protein HUB98_RS16395 ENOG4105CDA abc transporter atp-binding protein HUB98_RS16400 ENOG4105E5Q amino acid AbC transporter HUB98_RS16405 ENOG4107R0W ABC transporter HUB98_RS16425 ENOG4108VAC response regulator HUB98_RS16455 ENOG41075H3 AraC family transcriptional regulator HUB98_RS16480 ENOG4105DWT malate dehydrogenase (quinone) HUB98_RS16490 ENOG4108RZA ABC transporter HUB98_RS16500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS16510 ENOG4105BZU Histidine kinase HUB98_RS16515 ENOG4105EUJ GTP cyclohydrolase i HUB98_RS16525 ENOG4108R85 Short chain dehydrogenase HUB98_RS16545 ENOG4105WN5 stage II sporulation protein HUB98_RS16580 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HUB98_RS16585 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUB98_RS16590 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HUB98_RS16595 ENOG4105CMG Carbohydrate kinase HUB98_RS16600 ENOG4105CMD Transcriptional regulator, GntR family HUB98_RS16605 ENOG4108HGU Histidine kinase HUB98_RS16615 ENOG4108NEV two component transcriptional regulator, LytTR family HUB98_RS16625 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUB98_RS16655 ENOG4105FCD Major Facilitator HUB98_RS16700 ENOG4105UIB (ABC) transporter HUB98_RS16705 ENOG4108JQ9 ABC transporter HUB98_RS16710 ENOG4107TFB basic membrane HUB98_RS16720 ENOG4105C26 Dehydrogenase HUB98_RS16730 ENOG4105C5H ABC transporter HUB98_RS16795 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the HUB98_RS16840 ENOG4105C0H protease HUB98_RS16850 ENOG4105Q2H domain protein HUB98_RS16865 ENOG4105BZU Histidine kinase HUB98_RS16870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS16875 ENOG4105DR5 peptidase HUB98_RS16885 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUB98_RS16890 ENOG4105CDU Replicative dna helicase HUB98_RS16895 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUB98_RS16900 ENOG4105BZR domain protein HUB98_RS16920 ENOG4108KGH TRANSCRIPTIONal HUB98_RS16925 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUB98_RS16935 ENOG4105DZ1 carboxypeptidase HUB98_RS16945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS16950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS16955 ENOG4108JQ7 (ABC) transporter HUB98_RS16960 ENOG4105C3U ABC transporter HUB98_RS16970 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUB98_RS16975 ENOG4108UUM single-stranded DNA-binding protein HUB98_RS16980 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HUB98_RS16995 ENOG4105VDK protein, conserved in bacteria HUB98_RS17000 ENOG4105D8X mechanosensitive ion channel HUB98_RS17010 ENOG4108ZDA Sporulation protein YyaC HUB98_RS17025 ENOG4105FA0 parb-like partition protein HUB98_RS17030 ENOG4107QJE Chromosome Partitioning Protein HUB98_RS17045 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUB98_RS17050 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HUB98_RS17055 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein HUB98_RS17060 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUB98_RS17065 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUB98_RS17070 ENOG4105VG0 50S ribosomal protein l34 HUB98_RS17080 ENOG4105C6Z Gluconate HUB98_RS17085 ENOG4105CMG Carbohydrate kinase HUB98_RS17090 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUB98_RS17095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUB98_RS17100 ENOG410848D S4 domain protein YaaA HUB98_RS17115 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUB98_RS17120 ENOG4105CPF Cell wall formation (By similarity) HUB98_RS17125 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUB98_RS17130 ENOG4105DHT Metal Dependent Phosphohydrolase HUB98_RS17165 ENOG4105CXN decarboxylase HUB98_RS17170 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUB98_RS17175 ENOG4105X0R protein from nitrogen regulatory protein P-II HUB98_RS17180 ENOG4105XVJ Protein of unknown function (DUF327) HUB98_RS17185 ENOG4105FA2 dna polymerase iii HUB98_RS17190 ENOG4105MA4 psp1 domain protein HUB98_RS17195 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HUB98_RS17200 ENOG41060K3 Methyltransferase HUB98_RS17205 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HUB98_RS17210 ENOG4105KRN Transcriptional regulator, abrb family HUB98_RS17215 ENOG4105DCI Phosphohydrolase HUB98_RS17220 ENOG4105F8V Hydrolase, tatD family HUB98_RS17225 ENOG41069ER domain protein HUB98_RS17230 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HUB98_RS17235 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUB98_RS17240 ENOG4105XFA sporulation peptidase YabG HUB98_RS17245 ENOG4105W42 Veg protein HUB98_RS17250 ENOG4105XEW small acid-soluble spore protein HUB98_RS17255 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUB98_RS17260 ENOG4105DFT pur operon repressor HUB98_RS17265 ENOG4105K4W Could be involved in septation (By similarity) HUB98_RS17270 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUB98_RS17275 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUB98_RS17295 ENOG4108JA2 transcriptioN-repair coupling factor HUB98_RS17300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HUB98_RS17305 ENOG4108M14 stage v sporulation protein t HUB98_RS17315 ENOG4108IY2 MazG family HUB98_RS17325 ENOG41082I2 s4 domain protein HUB98_RS17330 ENOG4105VYY sporulation protein yabp HUB98_RS17345 ENOG41060GV RNA binding s1 domain protein HUB98_RS17370 ENOG4108UGV hypoxanthine phosphoribosyltransferase HUB98_RS17375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUB98_RS17380 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUB98_RS17385 ENOG4108IYU L-aspartate oxidase HUB98_RS17395 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUB98_RS17400 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HUB98_RS17405 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HUB98_RS17410 ENOG4105C6T cysteine synthase HUB98_RS17415 ENOG4105CRQ synthase (Component I) HUB98_RS17420 ENOG4105DDQ anthranilate synthase HUB98_RS17425 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HUB98_RS17430 ENOG4105EEI dihydropteroate synthase HUB98_RS17435 ENOG4105KRF dihydroneopterin aldolase HUB98_RS17440 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUB98_RS17450 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HUB98_RS17470 ENOG4105W1N transcriptional regulator HUB98_RS17475 ENOG4105IIP Membrane HUB98_RS17495 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUB98_RS17515 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUB98_RS17545 ENOG4105D9U N-acetyltransferase HUB98_RS17550 ENOG4108Z6B deaminase HUB98_RS17555 ENOG4105BZU Histidine kinase HUB98_RS17560 ENOG4105FE9 pseudouridine synthase HUB98_RS17565 ENOG4105ER2 Ompa motb domain protein HUB98_RS17570 ENOG4105E14 MotA TolQ exbB proton channel HUB98_RS17580 ENOG41090A4 Pterin carbinolamine dehydratase HUB98_RS17595 ENOG4107TT5 NLP P60 protein HUB98_RS17610 ENOG4108XFG YwhD family HUB98_RS17615 ENOG4105BZ4 penicillin-binding protein HUB98_RS17620 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HUB98_RS17640 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUB98_RS17655 ENOG4105C75 arginyL-tRNA synthetase HUB98_RS17665 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) HUB98_RS17670 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUB98_RS17685 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUB98_RS17690 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HUB98_RS17700 ENOG41082DI 50s ribosomal protein l31 HUB98_RS17710 ENOG4105C6E dna polymerase iii HUB98_RS17715 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUB98_RS17720 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUB98_RS17800 ENOG4105G9B Transcriptional regulator HUB98_RS17810 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HUB98_RS17820 ENOG4107XGZ Hydrolase HUB98_RS17825 ENOG4108S4C acetyltransferase HUB98_RS17830 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HUB98_RS17835 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUB98_RS17840 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUB98_RS17845 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUB98_RS17850 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUB98_RS17855 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUB98_RS17860 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUB98_RS17865 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUB98_RS17870 ENOG4107RVV histidinol phosphate phosphatase, hisj family HUB98_RS17875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUB98_RS17880 ENOG41075H3 AraC family transcriptional regulator HUB98_RS17885 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS17895 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS17920 ENOG4106F5Q Membrane HUB98_RS17925 ENOG4105DKQ ROK family HUB98_RS17930 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUB98_RS17935 ENOG4105CHW UPF0052 protein HUB98_RS17940 ENOG4105CIE May be required for sporulation (By similarity) HUB98_RS17945 ENOG4105KRI phosphocarrier protein (HPr HUB98_RS17960 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUB98_RS17980 ENOG4105BZA Phosphoglycerate kinase HUB98_RS17985 ENOG4105CP7 Triose-phosphate isomerase HUB98_RS17990 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUB98_RS17995 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUB98_RS18000 ENOG4105XZU Preprotein translocase, subunit SecG HUB98_RS18005 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUB98_RS18010 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUB98_RS18080 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUB98_RS18095 ENOG4107Y03 Nitroreductase HUB98_RS18105 ENOG4105FTV AraC Family Transcriptional Regulator HUB98_RS18120 ENOG4105CUY Mechanosensitive ion channel HUB98_RS18125 ENOG4108V5C ABC transporter HUB98_RS18145 ENOG4108MCI Transcriptional regulator, ARAC family HUB98_RS18155 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HUB98_RS18160 ENOG4107S2N Type III effector Hrp-dependent HUB98_RS18165 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HUB98_RS18170 ENOG4108JU7 Transcriptional regulator HUB98_RS18180 ENOG41087YS Phage shock protein A HUB98_RS18185 ENOG4105DQX Zinc finger domain HUB98_RS18190 ENOG4108WV1 Pfam:DUF477 HUB98_RS18205 ENOG4105VPS UPF0291 protein HUB98_RS18210 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HUB98_RS18220 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein HUB98_RS18235 ENOG4106N3A copper homeostasis protein cutc HUB98_RS18255 ENOG4105CK5 oxidoreductase HUB98_RS18270 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS18280 ENOG41075H3 AraC family transcriptional regulator HUB98_RS18340 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUB98_RS18345 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUB98_RS18350 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUB98_RS18360 ENOG4105C08 Histidine kinase HUB98_RS18365 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUB98_RS18370 ENOG41090U3 tautomerase HUB98_RS18375 ENOG4105BZU Histidine kinase HUB98_RS18380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS18390 ENOG4105CJ2 (LipO)protein HUB98_RS18415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS18420 ENOG4107RRN ABC transporter substrate-binding protein HUB98_RS18430 ENOG4108JQ6 ABC transporter HUB98_RS18445 ENOG4108Z7R Chaperone CsaA HUB98_RS18450 ENOG4105DBI uridine monophosphokinase HUB98_RS18465 ENOG4105C0D helicase HUB98_RS18470 ENOG4105KBK Zinc finger, swim domain protein HUB98_RS18480 ENOG4105FKZ Methyl-accepting chemotaxis HUB98_RS18485 ENOG4105F5H Glycosyl Hydrolase Family 88 HUB98_RS18495 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUB98_RS18500 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUB98_RS18505 ENOG4105C2F Histidine kinase HUB98_RS18510 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS18620 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUB98_RS18625 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUB98_RS18630 ENOG4105D7K pfkb domain protein HUB98_RS18635 ENOG4105C26 Dehydrogenase HUB98_RS18640 ENOG4105CK5 oxidoreductase HUB98_RS18645 ENOG4105DH8 myo-inositol catabolism HUB98_RS18650 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS18655 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS18675 ENOG4108VNY MOSC domain protein HUB98_RS18690 ENOG4107SDU Methyl-accepting chemotaxis HUB98_RS18695 ENOG4105CA9 Pyruvate kinase HUB98_RS18700 ENOG4108W3Q Transcriptional regulator HUB98_RS18715 ENOG4105VEQ Cold shock protein HUB98_RS18730 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUB98_RS18735 ENOG4108WYP Transcriptional regulator HUB98_RS18740 ENOG4105C8Y Acetylornithine aminotransferase HUB98_RS18745 ENOG4105CYW agmatinase HUB98_RS18870 ENOG4105D38 putrescine abc transporter HUB98_RS18875 ENOG4105CN5 Metallo-Beta-Lactamase HUB98_RS18880 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUB98_RS18885 ENOG4106KNT transcriptional regulator HUB98_RS18890 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUB98_RS18895 ENOG4105RD7 BadF BadG BcrA BcrD HUB98_RS18910 ENOG4105DRS transport system, permease HUB98_RS18925 ENOG4105EHZ conserved protein UCP016719 HUB98_RS18930 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUB98_RS18940 ENOG4108A04 Beta-lactamase HUB98_RS18945 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS18955 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS18995 ENOG4107VGF ig domain protein group 2 domain protein HUB98_RS19000 ENOG4105FGV Chromate HUB98_RS19005 ENOG4105CAH Chromate HUB98_RS19050 ENOG4107V6Q Cyclic nucleotide-binding domain HUB98_RS19105 ENOG4105EQ0 Major Facilitator superfamily HUB98_RS19110 ENOG4108JGH Tetr family transcriptional regulator HUB98_RS19115 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUB98_RS19175 ENOG4108JJB ABC transporter HUB98_RS19300 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUB98_RS19340 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS19360 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HUB98_RS19400 ENOG4105C2F Histidine kinase HUB98_RS19405 ENOG4105EQD regulatoR HUB98_RS19430 ENOG4107EFR Flavocytochrome c HUB98_RS19435 ENOG4105DRP amino acid AbC transporter HUB98_RS19440 ENOG4105EAD ABC transporter HUB98_RS19445 ENOG4105CT1 (ABC) transporter HUB98_RS19460 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HUB98_RS19470 ENOG4105CV8 reductase HUB98_RS19475 ENOG4106BRA Membrane HUB98_RS19495 ENOG4105KTB nuclear export factor GLE1 HUB98_RS19500 ENOG4105FXM Copper resistance protein HUB98_RS19510 ENOG4105ENE Histidine kinase HUB98_RS19540 ENOG4108JQ9 ABC transporter HUB98_RS19545 ENOG4105UIB (ABC) transporter HUB98_RS19585 ENOG41082MP copper ion binding protein HUB98_RS19590 ENOG4105C59 p-type ATPase HUB98_RS19605 ENOG4107T0D ABC, transporter HUB98_RS19620 ENOG41067SE Tetr family transcriptional regulator HUB98_RS19625 ENOG4108DBC nitroreductase HUB98_RS19630 ENOG4108RE7 deoxyribonuclease HUB98_RS19640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUB98_RS19655 ENOG41081I9 integral membrane protein HUB98_RS19660 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUB98_RS19665 ENOG4107VGF ig domain protein group 2 domain protein HUB98_RS19700 ENOG4105P4J Allophanate hydrolase, subunit 1 HUB98_RS19710 ENOG4105E7W lamb ycsf family protein HUB98_RS19720 ENOG410606W general stress protein HUB98_RS19725 ENOG4105CGH 5'-nucleotidase HUB98_RS19735 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS19740 ENOG4107R5R arsenical pump membrane protein HUB98_RS19745 ENOG4105CVA phosphate HUB98_RS19750 ENOG4105C8U phosphate abc transporter HUB98_RS19755 ENOG4105E2Z phosphate ABC transporter (Permease HUB98_RS19760 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS19780 ENOG4105BZU Histidine kinase HUB98_RS19800 ENOG4105EJQ L-serine dehydratase HUB98_RS19835 ENOG4105BZU Histidine kinase HUB98_RS19850 ENOG4105G0J serine threonine protein kinase HUB98_RS19855 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUB98_RS19860 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUB98_RS19885 ENOG41063TF transcriptional regulator (AraC HUB98_RS19890 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUB98_RS19895 ENOG4108I5D sulfate abc transporter HUB98_RS19915 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUB98_RS19955 ENOG4108RYK Nad-dependent epimerase dehydratase HUB98_RS19960 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HUB98_RS19970 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS19975 ENOG4105DIH basic membrane HUB98_RS19980 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUB98_RS19985 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUB98_RS19990 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HUB98_RS20010 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUB98_RS20015 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUB98_RS20035 ENOG4105K6V RNA polymerase HUB98_RS20050 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUB98_RS20060 ENOG4105BZU Histidine kinase HUB98_RS20070 ENOG4105K4T epimerase HUB98_RS20075 ENOG4105KME endoribonuclease L-psp HUB98_RS20090 ENOG4105EQD regulatoR HUB98_RS20095 ENOG4105C2F Histidine kinase HUB98_RS20115 ENOG4108IG5 Transcriptional regulator HUB98_RS20130 ENOG4105C0D helicase HUB98_RS20140 ENOG4108VXD carboxy-peptidase HUB98_RS20160 ENOG4105CK5 oxidoreductase HUB98_RS20200 ENOG41081VB Hydrolase HUB98_RS20210 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUB98_RS20215 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HUB98_RS20240 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HUB98_RS20245 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUB98_RS20260 ENOG41064X9 cytochrome C oxidase subunit IV HUB98_RS20290 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS20295 ENOG4105DVE abc transporter atp-binding protein HUB98_RS20300 ENOG4108IUX (ABC) transporter HUB98_RS20305 ENOG4105RHA ABC transporter, permease HUB98_RS20310 ENOG4108QY0 Membrane HUB98_RS20335 ENOG4105DMQ Methyltransferase HUB98_RS20340 ENOG4105EMN RNA polymerase sigma factor HUB98_RS20350 ENOG4105EWC Purine nucleoside phosphorylase HUB98_RS20355 ENOG4108RCM Nitroreductase HUB98_RS20360 ENOG4105K56 Transcriptional regulator HUB98_RS20365 ENOG4105DYS nad(p)h dehydrogenase (quinone) HUB98_RS20370 ENOG4105WAB arsR family transcriptional regulator HUB98_RS20375 ENOG4105DEN Luciferase family HUB98_RS20390 ENOG4105C59 p-type ATPase HUB98_RS20400 ENOG4107SWG transcriptional regulator MERR family HUB98_RS20405 ENOG4105DXB Major Facilitator superfamily HUB98_RS20445 ENOG4107Y80 Major Facilitator superfamily HUB98_RS20475 ENOG4105CBX hi0933 family HUB98_RS20480 ENOG4105BZU Histidine kinase HUB98_RS20485 ENOG4108Y6J UPF0403 protein HUB98_RS20495 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUB98_RS20525 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUB98_RS20535 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HUB98_RS20550 ENOG4105EUJ GTP cyclohydrolase i HUB98_RS20555 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HUB98_RS20565 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUB98_RS20575 ENOG4107258 Transcriptional regulator HUB98_RS20580 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUB98_RS20600 ENOG4105D29 Helix-turn-helix type 11 domain protein HUB98_RS20630 ENOG4107QM5 aconitate hydratase HUB98_RS20640 ENOG4105CPF Cell wall formation (By similarity) HUB98_RS20655 ENOG4105ECY inositol monophosphatase HUB98_RS20670 ENOG4105C2F Histidine kinase HUB98_RS20675 ENOG4105EQD regulatoR HUB98_RS20680 ENOG410769Z extracellular solute-binding protein family 1 HUB98_RS20685 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUB98_RS20690 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUB98_RS20695 ENOG4107TDE lipolytic protein G-D-S-L family HUB98_RS20705 ENOG4105SX7 Transporter HUB98_RS20715 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUB98_RS20725 ENOG4108IUW ABC transporter HUB98_RS20740 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUB98_RS20760 ENOG4108Q5U germination protein, ger(x)c family HUB98_RS20765 ENOG4105E1K spore germination protein HUB98_RS20770 ENOG4107ZTW SNARE associated Golgi HUB98_RS20780 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUB98_RS20800 ENOG4105I03 Flagellin HUB98_RS20805 ENOG4105C7N Xanthine uracil vitamin C permease HUB98_RS20830 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUB98_RS20860 ENOG4107YZX Universal stress protein HUB98_RS20865 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HUB98_RS20870 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HUB98_RS20875 ENOG4105C83 adenylosuccinate lyase HUB98_RS20880 ENOG4105C8V SAICAR synthetase HUB98_RS20885 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HUB98_RS20890 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUB98_RS20895 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUB98_RS20910 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUB98_RS20915 ENOG4108V3E phosphoribosylglycinamide formyltransferase HUB98_RS20925 ENOG4107QNG Phosphoribosylglycinamide synthetase HUB98_RS20930 ENOG4105C37 (CBS) domain HUB98_RS20935 ENOG4105C37 (CBS) domain HUB98_RS20940 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HUB98_RS20945 ENOG4105FBA Phospholipase Carboxylesterase HUB98_RS20950 ENOG4108YIQ Alpha beta hydrolase HUB98_RS20955 ENOG4105C7B Threonine dehydratase HUB98_RS20975 ENOG4108CIP transcriptional regulator HUB98_RS20995 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUB98_RS21010 ENOG4108R5T secreted protein HUB98_RS21015 ENOG4107GRR phosphate transport regulator HUB98_RS21020 ENOG4105CJ3 phosphate transporter HUB98_RS21025 ENOG4105D7N magnesium and cobalt transport protein CorA HUB98_RS21030 ENOG4105F1N DNA alkylation repair HUB98_RS21040 ENOG4105KGF protein, YerC YecD HUB98_RS21055 ENOG4105CBD Diacylglycerol kinase HUB98_RS21060 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUB98_RS21065 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUB98_RS21070 ENOG4105CEY Amp-dependent synthetase and ligase HUB98_RS21095 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUB98_RS21105 ENOG4105CJ1 ABC, transporter HUB98_RS21155 ENOG4105NTD Inherit from COG: Hydrolase HUB98_RS21190 ENOG4108NEV two component transcriptional regulator, LytTR family HUB98_RS21205 ENOG4105T0Z Conserved Protein HUB98_RS21225 ENOG4108RSN SNARE associated Golgi HUB98_RS21230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS21235 ENOG4108SWU Histidine kinase HUB98_RS21250 ENOG4105BZ1 (ABC) transporter HUB98_RS21255 ENOG4105BZ1 (ABC) transporter HUB98_RS21260 ENOG4105I03 Flagellin HUB98_RS21260 ENOG4105I03 Flagellin HUB98_RS21280 ENOG4105EX0 alpha-galactosidase HUB98_RS21290 ENOG4108NEV two component transcriptional regulator, LytTR family HUB98_RS21300 ENOG4105C0H protease HUB98_RS21315 ENOG4108R6W Transcriptional regulator, ARAC family HUB98_RS21320 ENOG4105F5H Glycosyl Hydrolase Family 88 HUB98_RS21325 ENOG4105CT8 Phosphorylase HUB98_RS21335 ENOG4105C2F Histidine kinase HUB98_RS21340 ENOG4105EQD regulatoR HUB98_RS21355 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS21385 ENOG4105CHH sulfate transporter HUB98_RS21395 ENOG4105C85 amino acid HUB98_RS21400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUB98_RS21415 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUB98_RS21450 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HUB98_RS21460 ENOG4107QZ7 Cellulose synthase catalytic subunit HUB98_RS21470 ENOG4107RVG penicillin-binding protein HUB98_RS21495 ENOG41062JF Transcriptional regulator HUB98_RS21530 ENOG4105ZMH deoxynucleoside kinase HUB98_RS21540 ENOG4107TXC Transcriptional regulator HUB98_RS21545 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUB98_RS21550 ENOG4105DWF phosphomethylpyrimidine kinase HUB98_RS21580 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS21585 ENOG4108UMI ABC transporter, permease HUB98_RS21590 ENOG4105D01 (LipO)protein HUB98_RS21595 ENOG4105BZU Histidine kinase HUB98_RS21600 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUB98_RS21630 ENOG4108QTI )-transporter HUB98_RS21650 ENOG4105CB2 alcohol dehydrogenase HUB98_RS21655 ENOG4108KSA LysR family transcriptional regulator HUB98_RS21665 ENOG4108MCI Transcriptional regulator, ARAC family HUB98_RS21675 ENOG4105CMT Dihydroxyacetone kinase HUB98_RS21685 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUB98_RS21690 ENOG4107H8F HUB98_RS21705 ENOG4107H8F HUB98_RS21710 ENOG4105I4A GCN5-related N-acetyltransferase HUB98_RS21730 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS21735 ENOG4105C5Q Transcriptional regulator HUB98_RS21780 ENOG4105F0F Oxalate decarboxylase HUB98_RS21790 ENOG4108MES Periplasmic binding protein HUB98_RS21795 ENOG4105DQ5 transport system permease protein HUB98_RS21800 ENOG4108IHU transport system permease protein HUB98_RS21805 ENOG4105E0A ABC, transporter HUB98_RS21810 ENOG4108DIG cyanophycin synthetase HUB98_RS21835 ENOG4105DUU IucA IucC family protein HUB98_RS21850 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUB98_RS21885 ENOG4105CFI type iii restriction protein res subunit HUB98_RS21895 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUB98_RS21925 ENOG4105CFI type iii restriction protein res subunit HUB98_RS21945 ENOG4105EMN RNA polymerase sigma factor HUB98_RS21965 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUB98_RS22005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUB98_RS22015 ENOG4105BZ1 (ABC) transporter HUB98_RS22020 ENOG4105BZ1 (ABC) transporter HUB98_RS22025 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HUB98_RS22030 ENOG4105GVF (ABC) transporter HUB98_RS22080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS22085 ENOG4105BZU Histidine kinase HUB98_RS22095 ENOG4105C19 ABC transporter HUB98_RS22100 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUB98_RS22110 ENOG41065HY 1,4-beta-cellobiosidase HUB98_RS22115 ENOG4105CX8 fg-gap repeat protein HUB98_RS22125 ENOG4107XNU peptidase HUB98_RS22130 ENOG4105EQD regulatoR HUB98_RS22135 ENOG4105CID antiterminator HUB98_RS22145 ENOG410901P UPF0249 protein HUB98_RS22170 ENOG4108HW3 (ABC) transporter HUB98_RS22175 ENOG4105E5Q amino acid AbC transporter HUB98_RS22180 ENOG4105CDA abc transporter atp-binding protein HUB98_RS22190 ENOG4105ECB domain protein HUB98_RS22230 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HUB98_RS22235 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HUB98_RS22255 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS22260 ENOG4105VEQ Cold shock protein HUB98_RS22265 ENOG4105EQD regulatoR HUB98_RS22270 ENOG4105C2F Histidine kinase HUB98_RS22275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUB98_RS22280 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HUB98_RS22285 ENOG4105C2J ABC transporter HUB98_RS22290 ENOG4108HWV )-transporter HUB98_RS22295 ENOG4105BZU Histidine kinase HUB98_RS22300 ENOG4105DHF Membrane HUB98_RS22335 ENOG4105EHG Permease protein HUB98_RS22340 ENOG4105DQ5 transport system permease protein HUB98_RS22345 ENOG410874W AraC family transcriptional regulator HUB98_RS22365 ENOG4105E63 Pfam:DUF178 HUB98_RS22370 ENOG4108UIH futalosine nucleosidase HUB98_RS22375 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS22380 ENOG4105DVE abc transporter atp-binding protein HUB98_RS22400 ENOG4105C87 Aminotransferase class I and II HUB98_RS22410 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUB98_RS22420 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS22425 ENOG4105CZV ABC transporter HUB98_RS22450 ENOG410756H nucleotidyltransferase HUB98_RS22480 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS22500 ENOG4105CK5 oxidoreductase HUB98_RS22510 ENOG4108DMH HTH_ARAC HUB98_RS22525 ENOG4105DCF alanine dehydrogenase HUB98_RS22545 ENOG4108JUB Transcriptional regulator HUB98_RS22550 ENOG41062BK proline dehydrogenase HUB98_RS22555 ENOG4105C26 Dehydrogenase HUB98_RS22560 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUB98_RS22565 ENOG4108IJ0 Aspartate ammonia-lyase HUB98_RS22570 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUB98_RS22600 ENOG4107ZE5 PPIases accelerate the folding of proteins HUB98_RS22605 ENOG4105C6X Major Facilitator HUB98_RS22630 ENOG4108HGU Histidine kinase HUB98_RS22660 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS22690 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUB98_RS22695 ENOG4107T8T UPF0173 metal-dependent hydrolase HUB98_RS22715 ENOG4105BZ1 (ABC) transporter HUB98_RS22730 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HUB98_RS22745 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUB98_RS22750 ENOG4106Z5D Glycoside Hydrolase Family 43 HUB98_RS22775 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUB98_RS22780 ENOG4105EU9 HUB98_RS22795 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUB98_RS22805 ENOG4108J8C transporter major facilitator family protein HUB98_RS22810 ENOG4105EU0 Major facilitator Superfamily HUB98_RS22820 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HUB98_RS22830 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HUB98_RS22865 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUB98_RS22870 ENOG4105CGH 5'-nucleotidase HUB98_RS22890 ENOG4105BZU Histidine kinase HUB98_RS22895 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS22935 ENOG4105PQS phage protein HUB98_RS22955 ENOG4108I7Y domain protein HUB98_RS22975 ENOG41066EA baseplate J family protein HUB98_RS23005 ENOG4105PQS phage protein HUB98_RS23030 ENOG4105X7F HUB98_RS23040 ENOG4105MFU Protein of unknown function (DUF2634) HUB98_RS23045 ENOG41066EA baseplate J family protein HUB98_RS23070 ENOG4105DEF Extracellular solute-binding protein, family 5 HUB98_RS23075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUB98_RS23080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUB98_RS23090 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUB98_RS23095 ENOG4105DEN Luciferase family HUB98_RS23100 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS23120 ENOG4105F0V Cell wall hydrolase HUB98_RS23125 ENOG4108QBV Monogalactosyldiacylglycerol synthase HUB98_RS23135 ENOG4105ECB domain protein HUB98_RS23160 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HUB98_RS23170 ENOG4107YJ4 chain length determinant protein HUB98_RS23175 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUB98_RS23185 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUB98_RS23205 ENOG4108TJN glycosyl transferase group 1 HUB98_RS23210 ENOG4105JNK Glycosyl transferase (Group 1 HUB98_RS23215 ENOG4105CPK Glycosyl transferase (Group 1 HUB98_RS23230 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUB98_RS23235 ENOG4108KGH TRANSCRIPTIONal HUB98_RS23250 ENOG4105CJ1 ABC, transporter HUB98_RS23255 ENOG4108TU7 Inherit from COG: (ABC) transporter HUB98_RS23260 ENOG4105C02 permease HUB98_RS23265 ENOG4105C37 (CBS) domain HUB98_RS23270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUB98_RS23275 ENOG4108JYZ YitT family HUB98_RS23280 ENOG4105DQE DNA ligase HUB98_RS23290 ENOG4108Q8B Spore germination protein HUB98_RS23300 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HUB98_RS23305 ENOG4105FDF Could be involved in DNA repair (By similarity) HUB98_RS23320 ENOG4105K8N protein family UPF0079, ATPase HUB98_RS23325 ENOG41072GX Peptidase M22 Glycoprotease HUB98_RS23330 ENOG410801F ribosomal-protein-alanine acetyltransferase HUB98_RS23335 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUB98_RS23350 ENOG4105C5H ABC transporter HUB98_RS23355 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HUB98_RS23360 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUB98_RS23365 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUB98_RS23370 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUB98_RS23375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUB98_RS23380 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUB98_RS23395 ENOG4105F9F transposase HUB98_RS23450 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HUB98_RS23455 ENOG4105C0X amino acid HUB98_RS23475 ENOG4108IJ7 Glycine betaine HUB98_RS23480 ENOG4105TRT Transcriptional regulator HUB98_RS23500 ENOG4105CJ1 ABC, transporter HUB98_RS23505 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUB98_RS23520 ENOG4105VZ8 Transcriptional regulator HUB98_RS23525 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HUB98_RS23530 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUB98_RS23540 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HUB98_RS23585 ENOG410667J hydrolase HUB98_RS23590 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS23635 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HUB98_RS23645 ENOG4108V06 Glutathione peroxidase HUB98_RS23665 ENOG4108ZHJ Organic hydroperoxide resistance protein HUB98_RS23680 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HUB98_RS23745 ENOG4105ECP epimerase HUB98_RS23760 ENOG4105CIY formyltetrahydrofolate deformylase HUB98_RS23780 ENOG4107QYV phosphohexose isomerase HUB98_RS23785 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUB98_RS23790 ENOG4108IG5 Transcriptional regulator HUB98_RS23795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HUB98_RS23800 ENOG4108I5D sulfate abc transporter HUB98_RS23815 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUB98_RS23825 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUB98_RS23835 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUB98_RS23840 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS23855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS23860 ENOG4108Q5Y Membrane HUB98_RS23875 ENOG410667J hydrolase HUB98_RS23880 ENOG4105DF9 Lipoate-protein, ligase HUB98_RS23885 ENOG4107QZB decarboxylase HUB98_RS23895 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUB98_RS23905 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUB98_RS23910 ENOG4105EHG Permease protein HUB98_RS23915 ENOG4105E0A ABC, transporter HUB98_RS23920 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUB98_RS23930 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUB98_RS23935 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUB98_RS23970 ENOG41069FQ Metallo-beta-lactamase superfamily HUB98_RS23985 ENOG4105C22 threonyL-tRNA synthetase HUB98_RS23995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS24000 ENOG41063SB peptidase HUB98_RS24005 ENOG4107TCE N-acetyltransferase HUB98_RS24055 ENOG4105BZ4 penicillin-binding protein HUB98_RS24065 ENOG4107XM3 UPF0442 protein HUB98_RS24070 ENOG4105DWK Membrane HUB98_RS24085 ENOG4105EMN RNA polymerase sigma factor HUB98_RS24105 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HUB98_RS24110 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HUB98_RS24115 ENOG4108UKS UPF0398 protein HUB98_RS24125 ENOG4105BZ1 (ABC) transporter HUB98_RS24135 ENOG4105C9U ATP-dependent DNA helicase RecQ HUB98_RS24150 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUB98_RS24265 ENOG4108UVJ appr-1-p processing domain protein HUB98_RS24305 ENOG4105CEY Amp-dependent synthetase and ligase HUB98_RS24330 ENOG4105D78 K07001 NTE family protein HUB98_RS24375 ENOG4105J76 Periplasmic binding protein HUB98_RS24390 ENOG4108Z15 abc transporter atp-binding protein HUB98_RS24400 ENOG4105Y2Z radical SAM domain protein HUB98_RS24410 ENOG4108R6W Transcriptional regulator, ARAC family HUB98_RS24465 ENOG41080V3 Major Facilitator superfamily HUB98_RS24470 ENOG4107RSM transcriptional regulator HUB98_RS24505 ENOG4108VAC response regulator HUB98_RS24510 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HUB98_RS24515 ENOG4105E8V Alpha Beta Hydrolase Fold protein HUB98_RS24520 ENOG4105C2F Histidine kinase HUB98_RS24530 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS24550 ENOG4108X0B nad(p)h dehydrogenase (quinone) HUB98_RS24555 ENOG4105KVH Transcriptional regulator HUB98_RS24600 ENOG4105PGM cation diffusion facilitator family transporter HUB98_RS24605 ENOG4105EFI regulatoR HUB98_RS24610 ENOG4105BZU Histidine kinase HUB98_RS24615 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HUB98_RS24620 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUB98_RS24660 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUB98_RS24745 ENOG4105JAB phenazine biosynthesis protein, phzf family HUB98_RS24825 ENOG4108N23 SpoOM-related protein HUB98_RS24835 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HUB98_RS24840 ENOG4108YYS metal-dependent hydrolase (By similarity) HUB98_RS24855 ENOG41088CC tellurite resistance protein tehB HUB98_RS24860 ENOG410904N short-chain dehydrogenase reductase HUB98_RS24875 ENOG4105E0Y RtcB Protein HUB98_RS24895 ENOG4105D9P serine threonine protein kinase HUB98_RS24910 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS24935 ENOG41080C8 DUF218 domain HUB98_RS24945 ENOG4105ECP epimerase HUB98_RS24950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUB98_RS24960 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUB98_RS24975 ENOG4105E1F short-chain dehydrogenase reductase HUB98_RS25005 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUB98_RS25020 ENOG4105CS9 pantothenic acid kinase HUB98_RS25045 ENOG4108W0I acetyltransferase HUB98_RS25060 ENOG4105C7S Dehydrogenase HUB98_RS25070 ENOG4105DG6 mannose-6-phosphate isomerase HUB98_RS25080 ENOG4105N5T Radical SAM Protein HUB98_RS25090 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUB98_RS25095 ENOG4107XVH Transcriptional regulator HUB98_RS25105 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS25110 ENOG4105E0S extracellular solute-binding protein family 1 HUB98_RS25115 ENOG4108QBV Monogalactosyldiacylglycerol synthase HUB98_RS25120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUB98_RS25130 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUB98_RS25135 ENOG41084BS 50S ribosomal protein L35 HUB98_RS25140 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUB98_RS25145 ENOG4105DIH basic membrane HUB98_RS25150 ENOG4108JQ9 ABC transporter HUB98_RS25155 ENOG4105UIB (ABC) transporter HUB98_RS25175 ENOG4105C7K acetolactate synthase HUB98_RS25180 ENOG4108ZP8 Acetolactate synthase small subunit HUB98_RS25185 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUB98_RS25190 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUB98_RS25195 ENOG4105CPC Aldo Keto reductase HUB98_RS25200 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUB98_RS25205 ENOG4105D3R alkyl hydroperoxide reductase HUB98_RS25230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUB98_RS25250 ENOG4105BZU Histidine kinase HUB98_RS25265 ENOG4105C5H ABC transporter HUB98_RS25270 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUB98_RS25280 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HUB98_RS25295 ENOG4105C98 muts2 protein HUB98_RS25330 ENOG4108ZB6 transcriptional regulator AsnC family HUB98_RS25335 ENOG4105CHM Aminotransferase HUB98_RS25355 ENOG4108WBT adenosyltransferase HUB98_RS25360 ENOG4105EMS pseudouridine synthase HUB98_RS25365 ENOG41080E8 Transcriptional regulator, Spx MgsR family HUB98_RS25380 ENOG4108RPX mosc domain containing protein HUB98_RS25385 ENOG4105EVU fructokinase HUB98_RS25395 ENOG4105D7N magnesium and cobalt transport protein CorA HUB98_RS25400 ENOG4105CVG Homoserine O-transsuccinylase HUB98_RS25405 ENOG4105C28 cystathionine HUB98_RS25410 ENOG4105C28 cystathionine HUB98_RS25415 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUB98_RS25420 ENOG4105CPC Aldo Keto reductase HUB98_RS25425 ENOG4105CPQ Dehydrogenase HUB98_RS25435 ENOG4107S91 Sodium hydrogen exchanger HUB98_RS25440 ENOG4105NCW Trka-c domain protein HUB98_RS25455 ENOG4105C22 threonyL-tRNA synthetase HUB98_RS25460 ENOG41069ER domain protein HUB98_RS25475 ENOG4105ENE Histidine kinase HUB98_RS25480 ENOG4105WH1 Two component transcriptional regulator luxr family HUB98_RS25485 ENOG4105C0H protease HUB98_RS25490 ENOG4105ETX regulatoR HUB98_RS25495 ENOG4105BZU Histidine kinase HUB98_RS25500 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUB98_RS25505 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HUB98_RS25510 ENOG4105C5F glutamine synthetase HUB98_RS25520 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUB98_RS25525 ENOG4108M14 stage v sporulation protein t HUB98_RS25535 ENOG4107UWA esterase HUB98_RS25545 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS25555 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUB98_RS25560 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS25565 ENOG4108HQ0 Exopolysaccharide biosynthesis protein HUB98_RS25580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUB98_RS25595 ENOG4105CYN Serine protein kinase HUB98_RS25600 ENOG4105C8Q Methyl-accepting chemotaxis HUB98_RS25605 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS25615 ENOG4105BZU Histidine kinase HUB98_RS25620 ENOG4105ED1 spovr family HUB98_RS25630 ENOG4105DEU major facilitator superfamily HUB98_RS25670 ENOG4105BZ1 (ABC) transporter HUB98_RS25675 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HUB98_RS25710 ENOG4105KZD Domain of unknown function (DUF1805) HUB98_RS25720 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HUB98_RS25725 ENOG4108RMU ferritin dps family protein HUB98_RS25735 ENOG4105C3K feS assembly ATPase SufC HUB98_RS25740 ENOG4105JRK feS assembly protein SufD HUB98_RS25745 ENOG4105C9B Cysteine desulfurase HUB98_RS25750 ENOG4108UNV SUF system FeS assembly protein, NifU family HUB98_RS25755 ENOG4105DIW FeS assembly protein SUFB HUB98_RS25780 ENOG4105CPI Metal Dependent Phosphohydrolase HUB98_RS25785 ENOG4108ZAF Molybdopterin HUB98_RS25790 ENOG4107R8B 5'-nucleotidase HUB98_RS25795 ENOG4105CPI Metal Dependent Phosphohydrolase HUB98_RS25805 ENOG4105C37 (CBS) domain HUB98_RS25820 ENOG4105WEF catalase HUB98_RS25850 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HUB98_RS25855 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUB98_RS25865 ENOG4105C2F Histidine kinase HUB98_RS25870 ENOG4105EQD regulatoR HUB98_RS25900 ENOG410839P HUB98_RS25910 ENOG410839P HUB98_RS25915 ENOG4105WZB UPF0342 protein HUB98_RS25940 ENOG4105VV2 HUB98_RS25960 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HUB98_RS25965 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HUB98_RS25970 ENOG4105CA9 Pyruvate kinase HUB98_RS25980 ENOG4105FS0 cytoplasmic membrane protein HUB98_RS25985 ENOG4108REF Sporulation integral membrane protein ytvi HUB98_RS25990 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUB98_RS26035 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HUB98_RS26115 ENOG4105CAR Terminase, large subunit HUB98_RS26240 ENOG4105XSJ toxin secretion phage lysis holin HUB98_RS26245 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUB98_RS26280 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUB98_RS26325 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HUB98_RS26570 ENOG4105XSJ toxin secretion phage lysis holin HUB98_RS26575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HUB98_RS26610 ENOG4105BZN citrate synthase HUB98_RS26615 ENOG4108HMX isocitrate dehydrogenase (NADP) HUB98_RS26620 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUB98_RS26640 ENOG4105BZU Histidine kinase HUB98_RS26645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUB98_RS26650 ENOG4108W2P Methyl-accepting chemotaxis HUB98_RS26655 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUB98_RS26660 ENOG4108UTW Plays a role in the regulation of phosphate uptake HUB98_RS26670 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUB98_RS26680 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUB98_RS26685 ENOG4107SC1 transglycosylase HUB98_RS26695 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUB98_RS26710 ENOG4108V4B ThiJ pfpI HUB98_RS26725 ENOG4107RSM transcriptional regulator HUB98_RS26740 ENOG4105E1K spore germination protein HUB98_RS26745 ENOG4108Q5U germination protein, ger(x)c family HUB98_RS26750 ENOG4108Q8B Spore germination protein HUB98_RS26755 ENOG4108YIQ Alpha beta hydrolase HUB98_RS26765 ENOG4105DNP FAD linked oxidase domain protein HUB98_RS26775 ENOG41067V3 Antibiotic biosynthesis monooxygenase HUB98_RS26780 ENOG4108TVJ Nitroreductase HUB98_RS26785 ENOG4105FS7 Transcriptional regulator HUB98_RS26795 ENOG4105E1J oxidoreductase HUB98_RS26815 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS26820 ENOG4105DE4 1-phosphofructokinase HUB98_RS26825 ENOG4105DM4 PTS System HUB98_RS26830 ENOG4105F0F Oxalate decarboxylase HUB98_RS26835 ENOG4105E1F short-chain dehydrogenase reductase HUB98_RS26845 ENOG4105DUM transcriptional regulator, lysR family HUB98_RS26855 ENOG4105BZU Histidine kinase HUB98_RS26920 ENOG4105QAT UPF0741 protein HUB98_RS26930 ENOG4107ZXU DSBA oxidoreductase HUB98_RS26945 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HUB98_RS26955 ENOG4107RB3 L-asparaginase HUB98_RS26965 ENOG4105C6X Major Facilitator HUB98_RS26970 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUB98_RS26975 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUB98_RS26980 ENOG4105C1Q protoporphyrinogen oxidase HUB98_RS26985 ENOG4105PNM synthesis protein HUB98_RS26990 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HUB98_RS26995 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUB98_RS27010 ENOG4107Z3H Transcriptional regulator, TetR family HUB98_RS27015 ENOG4105C5H ABC transporter HUB98_RS27020 ENOG4105DER m42 family HUB98_RS27030 ENOG4105DPN Oligoendopeptidase f HUB98_RS27045 ENOG4105VEQ Cold shock protein HUB98_RS27070 ENOG4107QMU Mate efflux family protein HUB98_RS27080 ENOG4107AYK membrAne HUB98_RS27085 ENOG4105C1J atp-dependent rna helicase HUB98_RS27105 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HUB98_RS27115 ENOG4105C5Q Transcriptional regulator HUB98_RS27140 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HUB98_RS27150 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUB98_RS27155 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUB98_RS27160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUB98_RS27180 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUB98_RS27200 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HUB98_RS27210 ENOG410667J hydrolase HUB98_RS27220 ENOG4105M18 -acetyltransferase HUB98_RS27225 ENOG4107T8Q Glycosyl transferase (Group 1 HUB98_RS27230 ENOG4108K88 Membrane HUB98_RS27255 ENOG4105K4H Nlp p60 protein HUB98_RS27270 ENOG4108MYR Secreted protein HUB98_RS27290 ENOG4105ETE Transcriptional regulator (LacI family HUB98_RS27305 ENOG4107RK0 Sucrose phosphorylase HUB98_RS27310 ENOG4105PXI polysaccharide deacetylase HUB98_RS27335 ENOG4105C0D helicase HUB98_RS27345 ENOG4108MEJ flavin reductase domain protein HUB98_RS27350 ENOG4105EXC Acyl-transferase HUB98_RS27360 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUB98_RS27365 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUB98_RS27370 ENOG4105C2F Histidine kinase HUB98_RS27380 ENOG4105CNT hydrolase family 2 HUB98_RS27390 ENOG41067TZ transcriptional regulator, MarR family HUB98_RS27395 ENOG4105MI2 HUB98_RS27400 ENOG4107SUZ Sodium/hydrogen exchanger family HUB98_RS27425 ENOG41075H3 AraC family transcriptional regulator HUB98_RS27435 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS27455 ENOG4108HRK Histidine kinase HUB98_RS27460 ENOG4105EQD regulatoR HUB98_RS27475 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS27485 ENOG4105C4C beta-galactosidase HUB98_RS27505 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUB98_RS27510 ENOG4107NBY Membrane HUB98_RS27515 ENOG41069ZX HUB98_RS27520 ENOG4105EEM helicase HUB98_RS27525 ENOG4105CPN adenine deaminase HUB98_RS27535 ENOG4108MCI Transcriptional regulator, ARAC family HUB98_RS27540 ENOG4105CJQ hydrolase, family 31 HUB98_RS27555 ENOG4105NTK Transcriptional repressor Mpra HUB98_RS27560 ENOG4105NWF RbsD or FucU transport HUB98_RS27565 ENOG4105KD7 acetyltransferase HUB98_RS27585 ENOG4105E66 phosphoriboisomerase A HUB98_RS27590 ENOG41090MY MarR family Transcriptional regulator HUB98_RS27595 ENOG4108Q52 Methyltransferase cognate corrinoid protein HUB98_RS27600 ENOG4105BZU Histidine kinase HUB98_RS27615 ENOG41067TZ transcriptional regulator, MarR family HUB98_RS27620 ENOG4105EYF MMPL domain protein HUB98_RS27625 ENOG4105XJB lipolytic protein G-D-S-L family HUB98_RS27645 ENOG4107QZW Altronate oxidoreductase HUB98_RS27650 ENOG4105CTX dehydratase HUB98_RS27675 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HUB98_RS27690 ENOG4105C2F Histidine kinase HUB98_RS27710 ENOG4105CNT hydrolase family 2 HUB98_RS27730 ENOG41086D8 Transcriptional regulator HUB98_RS27735 ENOG4106H78 methyltransferase HUB98_RS27740 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUB98_RS27745 ENOG4105H20 Sporulation integral membrane protein YlbJ HUB98_RS27750 ENOG41063PX domain protein HUB98_RS27755 ENOG4105CDE UPF0348 protein HUB98_RS27765 ENOG41067VY 50S ribosomal protein L32 HUB98_RS27770 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HUB98_RS27775 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUB98_RS27785 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUB98_RS27790 ENOG4105CHR reductase HUB98_RS27795 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUB98_RS27800 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUB98_RS27805 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUB98_RS27810 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUB98_RS27815 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HUB98_RS27820 ENOG4108UT2 hemolysin iii HUB98_RS27825 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HUB98_RS27835 ENOG4105K5M 30s ribosomal protein S16 HUB98_RS27845 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUB98_RS27855 ENOG4107BJW polysaccharide deacetylase HUB98_RS27860 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUB98_RS27870 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HUB98_RS27875 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUB98_RS27885 ENOG4105D00 flagellar biosynthetic protein flhB HUB98_RS27890 ENOG4105VFF UPF0102 protein HUB98_RS27895 ENOG4107Y03 Nitroreductase HUB98_RS27900 ENOG4105C0P Mg chelatase subunit ChlI HUB98_RS27905 ENOG4105K56 Transcriptional regulator HUB98_RS27910 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUB98_RS27915 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HUB98_RS27925 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUB98_RS27930 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HUB98_RS27935 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HUB98_RS27940 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HUB98_RS27945 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HUB98_RS27950 ENOG4108ZC9 flagellar basal-body rod protein flgc HUB98_RS27960 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HUB98_RS27965 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HUB98_RS27980 ENOG4106YF4 Flagellar biosynthesis chaperone HUB98_RS27995 ENOG410822I Flagellar hook capping protein HUB98_RS28005 ENOG4108JQA flagellar HUB98_RS28020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HUB98_RS28025 ENOG4105DD5 Flagellar motor switch protein HUB98_RS28030 ENOG4107YTP response regulator receiver protein HUB98_RS28040 ENOG4105CN7 Flagellar biosynthetic protein FliP HUB98_RS28045 ENOG4105VS8 Flagellar biosynthetic protein fliq HUB98_RS28050 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HUB98_RS28055 ENOG4105D00 flagellar biosynthetic protein flhB HUB98_RS28060 ENOG4105D7B Flagellar biosynthesis protein flha HUB98_RS28065 ENOG4105FZW flagellar biosynthesis regulator FlhF HUB98_RS28075 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUB98_RS28080 ENOG4105CBS Chea signal transduction histidine kinase HUB98_RS28085 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HUB98_RS28095 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HUB98_RS28105 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUB98_RS28130 ENOG4105CE9 30S ribosomal protein S2 HUB98_RS28140 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUB98_RS28145 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUB98_RS28150 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUB98_RS28155 ENOG4105KNE Phosphatidate cytidylyltransferase HUB98_RS28160 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUB98_RS28165 ENOG4105DZP Membrane-associated zinc metalloprotease HUB98_RS28170 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUB98_RS28175 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HUB98_RS28180 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HUB98_RS28185 ENOG4105CHV Transcription elongation factor NusA HUB98_RS28195 ENOG4105VHM ribosomal protein HUB98_RS28205 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUB98_RS28210 ENOG4105SFS phosphoesterase RecJ domain protein HUB98_RS28215 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUB98_RS28220 ENOG4105DTN riboflavin biosynthesis protein ribF HUB98_RS28225 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUB98_RS28230 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUB98_RS28240 ENOG4105C1V Peptidase, M16 HUB98_RS28245 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUB98_RS28250 ENOG4105E35 Dipicolinate synthase subunit A HUB98_RS28255 ENOG4108S0H Dipicolinic acid synthetase, b subunit HUB98_RS28265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUB98_RS28270 ENOG4105CN5 Metallo-Beta-Lactamase HUB98_RS28275 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HUB98_RS28285 ENOG4105CNU cell division protein FtsK HUB98_RS28305 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HUB98_RS28335 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HUB98_RS28340 ENOG4105CEV competence damage-inducible protein HUB98_RS28345 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUB98_RS28355 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HUB98_RS28360 ENOG4105D48 metallophosphoesterase HUB98_RS28365 ENOG4105MCT stage V sporulation protein S HUB98_RS28370 ENOG4108IGT Dipeptidase HUB98_RS28375 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HUB98_RS28380 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUB98_RS28405 ENOG4105DAP Nicotinate phosphoribosyltransferase HUB98_RS28425 ENOG4105EPU Molybdenum cofactor synthesis domain protein HUB98_RS28430 ENOG4105CKI cobalamin synthesis protein HUB98_RS28435 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HUB98_RS28440 ENOG4105C75 arginyL-tRNA synthetase HUB98_RS28450 ENOG4105BZ1 (ABC) transporter HUB98_RS28455 ENOG4105BZ1 (ABC) transporter HUB98_RS28460 ENOG4105W8X HesB YadR YfhF-family protein HUB98_RS28465 ENOG41062IR nudix hydrolase HUB98_RS28475 ENOG4108VMM UPF0756 membrane protein HUB98_RS28480 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HUB98_RS28485 ENOG4105KTU Transcriptional regulator, arsr family HUB98_RS28495 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HUB98_RS28500 ENOG4105VRR gCN5-related N-acetyltransferase HUB98_RS28520 ENOG4105EC2 ftsk spoIIIe HUB98_RS28555 ENOG4105CHR reductase HUB98_RS28560 ENOG4105CQ7 ATP-dependent helicase HUB98_RS28605 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HUB98_RS28610 ENOG4108Z40 Transcriptional regulator HUB98_RS28750 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUB98_RS28770 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUB98_RS28775 ENOG4105DRS transport system, permease HUB98_RS28805 ENOG4105EQD regulatoR HUB98_RS28810 ENOG4105C2F Histidine kinase HUB98_RS28815 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUB98_RS28820 ENOG4105C2J ABC transporter HUB98_RS28825 ENOG4107R9N ABC transporter HUB98_RS28830 ENOG41062B0 ABC transporter, permease HUB98_RS28835 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUB98_RS28870 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HUB98_RS28890 ENOG4108V06 Glutathione peroxidase HUB98_RS28910 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HUB98_RS28925 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUB98_RS28935 ENOG41080UQ Transcriptional regulator HUB98_RS28945 ENOG4107P2S Transcriptional regulator HUB98_RS28960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUB98_RS28965 ENOG4105BZU Histidine kinase HUB98_RS28970 ENOG4107QIV Cytochrome c biogenesis protein HUB98_RS28975 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUB98_RS28980 ENOG4105E0X reductase HUB98_RS29000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUB98_RS29005 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS29010 ENOG4108X3M OsmC Ohr family protein HUB98_RS29025 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HUB98_RS29030 ENOG4108VA3 3-hexulose-6-phosphate synthase HUB98_RS29035 ENOG41080HJ 6-phospho 3-hexuloisomerase HUB98_RS29040 ENOG4105KVH Transcriptional regulator HUB98_RS29045 ENOG4105DPN Oligoendopeptidase f HUB98_RS29055 ENOG4105DET Rhamnulokinase HUB98_RS29060 ENOG4105E98 transcriptional regulator DeoR family HUB98_RS29065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUB98_RS29070 ENOG4107QR9 Iron-sulfur cluster binding protein HUB98_RS29075 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HUB98_RS29080 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HUB98_RS29090 ENOG4105DDC Oxidoreductase domain protein HUB98_RS29100 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUB98_RS29110 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HUB98_RS29120 ENOG4108HUF Transporter HUB98_RS29125 ENOG4106AXJ AraC family transcriptional regulator HUB98_RS29130 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUB98_RS29135 ENOG4105E0M Sulfatase HUB98_RS29140 ENOG4105DEN Luciferase family HUB98_RS29145 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUB98_RS29155 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HUB98_RS29160 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUB98_RS29175 ENOG4105BZU Histidine kinase HUB98_RS29195 ENOG4105C0A alcohol dehydrogenase