locus-tag	class	description
HUB98_RS00025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUB98_RS00030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUB98_RS00035	COG0058	SHG alpha-glucan phosphorylase activity
HUB98_RS00040	COG2207	Transcriptional regulator
HUB98_RS00040	COG3708	Transcriptional regulator
HUB98_RS00050	COG0366	Alpha amylase catalytic
HUB98_RS00055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUB98_RS00065	COG0366	Alpha amylase catalytic
HUB98_RS00070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS00070	COG1263	PTS System
HUB98_RS00080	COG4989	oxidoreductase activity
HUB98_RS00090	COG4209	transmembrane transport
HUB98_RS00100	COG0395	ABC-type sugar transport system, permease component
HUB98_RS00105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUB98_RS00110	COG1486	melibiose metabolic process
HUB98_RS00140	COG4122	O-methyltransferase activity
HUB98_RS00150	COG3619	membrane
HUB98_RS00155	COG2357	RelA SpoT domain protein
HUB98_RS00160	COG2814	Major facilitator Superfamily
HUB98_RS00170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUB98_RS00180	COG1073	alpha beta
HUB98_RS00185	COG3401	FG-GAP repeat protein
HUB98_RS00185	COG2755	lipolytic protein G-D-S-L family
HUB98_RS00190	COG1320	monovalent cation:proton antiporter activity
HUB98_RS00195	COG2212	antiporter activity
HUB98_RS00200	COG1863	multisubunit Na H antiporter MnhE subunit
HUB98_RS00205	COG0651	ATP synthesis coupled electron transport
HUB98_RS00210	COG1006	Multisubunit Na H antiporter MnhC subunit
HUB98_RS00230	COG2199	diguanylate cyclase activity
HUB98_RS00230	COG2203	Gaf domain
HUB98_RS00245	COG1528	Iron-storage protein
HUB98_RS00250	COG0726	polysaccharide deacetylase
HUB98_RS00255	COG2197	response regulator
HUB98_RS00260	COG4585	Histidine kinase
HUB98_RS00265	COG3239	Fatty acid desaturase
HUB98_RS00270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS00275	COG1940	carbohydrate kinase activity
HUB98_RS00280	COG1940	carbohydrate kinase activity
HUB98_RS00305	COG4209	transmembrane transport
HUB98_RS00310	COG0395	ABC-type sugar transport system, permease component
HUB98_RS00335	COG0747	negative chemotaxis
HUB98_RS00370	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS00380	COG1136	(ABC) transporter
HUB98_RS00380	COG0577	efflux transmembrane transporter activity
HUB98_RS00385	COG0745	RESPONSE REGULATOR receiver
HUB98_RS00390	COG5002	protein histidine kinase activity
HUB98_RS00395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUB98_RS00405	COG2814	Major facilitator Superfamily
HUB98_RS00410	COG1309	transcriptional regulator
HUB98_RS00420	COG1609	Transcriptional regulator
HUB98_RS00425	COG1063	alcohol dehydrogenase
HUB98_RS00440	COG1472	Belongs to the glycosyl hydrolase 3 family
HUB98_RS00460	COG0667	Aldo Keto reductase
HUB98_RS00470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUB98_RS00480	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HUB98_RS00485	COG0778	Nitroreductase
HUB98_RS00495	COG1876	peptidase activity
HUB98_RS00520	COG0488	(ABC) transporter
HUB98_RS00525	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS00535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUB98_RS00560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUB98_RS00580	COG1201	RNA secondary structure unwinding
HUB98_RS00605	COG2188	Transcriptional regulator
HUB98_RS00610	COG0457	Tetratricopeptide repeat
HUB98_RS00615	COG3347	Dehydrogenase
HUB98_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS00620	COG4806	L-rhamnose isomerase
HUB98_RS00625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUB98_RS00630	COG1609	Transcriptional regulator
HUB98_RS00635	COG1621	beta-fructofuranosidase activity
HUB98_RS00640	COG1263	PTS System
HUB98_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS00640	COG2190	(PTS) system
HUB98_RS00645	COG3546	catalase activity
HUB98_RS00650	COG3618	amidohydrolase
HUB98_RS00655	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS00660	COG3711	transcriptional antiterminator
HUB98_RS00670	COG1268	BioY protein
HUB98_RS00680	COG1122	ATPase activity
HUB98_RS00705	COG0385	Bile acid
HUB98_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS00715	COG0730	response to heat
HUB98_RS00725	COG4533	DNA binding
HUB98_RS00730	COG2211	Major facilitator Superfamily
HUB98_RS00735	COG1132	(ABC) transporter
HUB98_RS00740	COG2274	protein secretion by the type I secretion system
HUB98_RS00745	COG0109	protoheme IX farnesyltransferase activity
HUB98_RS00750	COG3634	alkyl hydroperoxide reductase activity
HUB98_RS00760	COG1309	transcriptional regulator
HUB98_RS00765	COG0477	Major facilitator Superfamily
HUB98_RS00770	COG0596	Alpha beta hydrolase
HUB98_RS00785	COG1396	sequence-specific DNA binding
HUB98_RS00795	COG2814	Major facilitator Superfamily
HUB98_RS00805	COG1609	Transcriptional regulator
HUB98_RS00810	COG2814	Major facilitator Superfamily
HUB98_RS00825	COG1404	Belongs to the peptidase S8 family
HUB98_RS00825	COG4412	M6 family metalloprotease domain protein
HUB98_RS00835	COG1609	Transcriptional regulator
HUB98_RS00845	COG1653	transport
HUB98_RS00850	COG1175	transmembrane transport
HUB98_RS00855	COG3833	ABC-type maltose transport systems, permease component
HUB98_RS00860	COG0383	alpha-mannosidase activity
HUB98_RS00865	COG0673	inositol 2-dehydrogenase activity
HUB98_RS00875	COG0673	inositol 2-dehydrogenase activity
HUB98_RS00880	COG2186	Transcriptional regulator
HUB98_RS00885	COG1473	amidohydrolase
HUB98_RS00890	COG4533	DNA binding
HUB98_RS00905	COG0823	Involved in the tonB-independent uptake of proteins
HUB98_RS00905	COG4946	Tricorn protease homolog
HUB98_RS00905	COG1506	peptidase
HUB98_RS00930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUB98_RS00935	COG0583	DNA-binding transcription factor activity
HUB98_RS00945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUB98_RS00965	COG2207	Transcriptional regulator
HUB98_RS00970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUB98_RS00990	COG5002	protein histidine kinase activity
HUB98_RS01005	COG1132	(ABC) transporter
HUB98_RS01010	COG1846	Transcriptional regulator
HUB98_RS01010	COG0456	acetyltransferase
HUB98_RS01030	COG0513	Belongs to the DEAD box helicase family
HUB98_RS01035	COG2315	Protein conserved in bacteria
HUB98_RS01060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS01065	COG2030	dehydratase
HUB98_RS01070	COG4977	sequence-specific DNA binding
HUB98_RS01080	COG1175	transmembrane transport
HUB98_RS01085	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01090	COG0697	spore germination
HUB98_RS01145	COG2801	Transposase and inactivated derivatives
HUB98_RS01160	COG3739	integral membrane protein
HUB98_RS01165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUB98_RS01190	COG1131	(ABC) transporter
HUB98_RS01195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS01200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUB98_RS01220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS01225	COG0789	Transcriptional regulator
HUB98_RS01230	COG1064	alcohol dehydrogenase
HUB98_RS01235	COG3973	AAA domain
HUB98_RS01240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUB98_RS01255	COG0590	tRNA wobble adenosine to inosine editing
HUB98_RS01275	COG0789	Transcriptional regulator
HUB98_RS01280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS01300	COG1609	Transcriptional regulator
HUB98_RS01305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUB98_RS01315	COG1129	ABC transporter
HUB98_RS01320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUB98_RS01325	COG1879	ABC-type sugar transport system periplasmic component
HUB98_RS01330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUB98_RS01335	COG3135	benzoate transporter
HUB98_RS01340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS01365	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS01365	COG4977	sequence-specific DNA binding
HUB98_RS01375	COG4753	response regulator
HUB98_RS01375	COG2207	Transcriptional regulator
HUB98_RS01375	COG2207	Transcriptional regulator
HUB98_RS01375	COG4753	response regulator
HUB98_RS01380	COG2972	Histidine kinase
HUB98_RS01390	COG4209	transmembrane transport
HUB98_RS01395	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01400	COG5520	Belongs to the glycosyl hydrolase 30 family
HUB98_RS01405	COG2732	(Barnase) inhibitor
HUB98_RS01410	COG4290	ribonuclease
HUB98_RS01420	COG2207	Transcriptional regulator
HUB98_RS01425	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS01430	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS01435	COG1653	transport
HUB98_RS01440	COG2972	Histidine kinase
HUB98_RS01445	COG2207	Transcriptional regulator
HUB98_RS01445	COG4753	response regulator
HUB98_RS01465	COG1175	transmembrane transport
HUB98_RS01470	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01490	COG1175	transmembrane transport
HUB98_RS01495	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01505	COG4977	sequence-specific DNA binding
HUB98_RS01510	COG4209	transmembrane transport
HUB98_RS01515	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01520	COG1653	transport
HUB98_RS01535	COG2382	esterase
HUB98_RS01535	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS01535	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS01550	COG2273	Hydrolase Family 16
HUB98_RS01560	COG1653	transport
HUB98_RS01565	COG2207	Transcriptional regulator
HUB98_RS01565	COG4753	response regulator
HUB98_RS01570	COG2972	Histidine kinase
HUB98_RS01575	COG4209	transmembrane transport
HUB98_RS01580	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01590	COG2201	protein-glutamate methylesterase activity
HUB98_RS01610	COG1309	transcriptional regulator
HUB98_RS01620	COG0730	response to heat
HUB98_RS01660	COG1902	pentaerythritol trinitrate reductase activity
HUB98_RS01665	COG1733	regulation of RNA biosynthetic process
HUB98_RS01680	COG1271	oxidase subunit
HUB98_RS01685	COG1294	oxidase, subunit
HUB98_RS01690	COG4988	ABC transporter
HUB98_RS01695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUB98_RS01705	COG0789	Transcriptional regulator
HUB98_RS01725	COG0789	Transcriptional regulator
HUB98_RS01750	COG3711	transcriptional antiterminator
HUB98_RS01755	COG2190	(PTS) system
HUB98_RS01755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS01755	COG1263	PTS System
HUB98_RS01760	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS01775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUB98_RS01785	COG2814	Major facilitator Superfamily
HUB98_RS01795	COG0745	RESPONSE REGULATOR receiver
HUB98_RS01800	COG2205	protein histidine kinase activity
HUB98_RS01805	COG1136	(ABC) transporter
HUB98_RS01825	COG0745	RESPONSE REGULATOR receiver
HUB98_RS01830	COG5002	protein histidine kinase activity
HUB98_RS01840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUB98_RS01860	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS01865	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS01870	COG0024	Methionine aminopeptidase
HUB98_RS01880	COG1819	glycosyl
HUB98_RS01905	COG4209	transmembrane transport
HUB98_RS01910	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01925	COG2207	Transcriptional regulator
HUB98_RS01925	COG4753	response regulator
HUB98_RS01930	COG2972	Histidine kinase
HUB98_RS01935	COG0395	ABC-type sugar transport system, permease component
HUB98_RS01940	COG4209	transmembrane transport
HUB98_RS01950	COG0596	Alpha beta hydrolase
HUB98_RS01955	COG0702	epimerase
HUB98_RS01965	COG0587	DNA-directed DNA polymerase activity
HUB98_RS01980	COG4149	molybdate abc transporter
HUB98_RS01985	COG3842	ATPase activity
HUB98_RS02000	COG0346	lactoylglutathione lyase activity
HUB98_RS02010	COG3459	Glycosyltransferase 36 associated
HUB98_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS02035	COG0804	urea catabolic process
HUB98_RS02040	COG0832	Belongs to the urease beta subunit family
HUB98_RS02040	COG0831	urea catabolic process
HUB98_RS02045	COG3708	Transcriptional regulator
HUB98_RS02045	COG2207	Transcriptional regulator
HUB98_RS02055	COG1940	carbohydrate kinase activity
HUB98_RS02060	COG2207	Transcriptional regulator
HUB98_RS02060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS02065	COG2211	Major facilitator Superfamily
HUB98_RS02070	COG3250	beta-galactosidase activity
HUB98_RS02115	COG0129	dihydroxy-acid dehydratase activity
HUB98_RS02120	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS02130	COG0583	DNA-binding transcription factor activity
HUB98_RS02135	COG2807	transmembrane transport
HUB98_RS02165	COG1307	EDD domain protein, DegV family
HUB98_RS02175	COG2372	response to copper ion
HUB98_RS02190	COG3275	phosphorelay sensor kinase activity
HUB98_RS02195	COG2207	Transcriptional regulator
HUB98_RS02195	COG4753	response regulator
HUB98_RS02205	COG4209	transmembrane transport
HUB98_RS02210	COG0395	ABC-type sugar transport system, permease component
HUB98_RS02215	COG0366	Alpha amylase catalytic
HUB98_RS02220	COG0366	Alpha amylase catalytic
HUB98_RS02225	COG0531	amino acid
HUB98_RS02235	COG0686	Belongs to the AlaDH PNT family
HUB98_RS02250	COG1937	Protein conserved in bacteria
HUB98_RS02265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUB98_RS02270	COG0745	RESPONSE REGULATOR receiver
HUB98_RS02275	COG0523	cobalamin synthesis protein
HUB98_RS02280	COG1469	GTP cyclohydrolase I activity
HUB98_RS02300	COG4209	transmembrane transport
HUB98_RS02305	COG0395	ABC-type sugar transport system, permease component
HUB98_RS02315	COG4753	response regulator
HUB98_RS02315	COG2207	Transcriptional regulator
HUB98_RS02320	COG2972	Histidine kinase
HUB98_RS02335	COG4209	transmembrane transport
HUB98_RS02340	COG0395	ABC-type sugar transport system, permease component
HUB98_RS02345	COG1653	transport
HUB98_RS02355	COG2323	membrane
HUB98_RS02380	COG1131	(ABC) transporter
HUB98_RS02395	COG0583	DNA-binding transcription factor activity
HUB98_RS02410	COG2826	transposase and inactivated derivatives, IS30 family
HUB98_RS02420	COG2610	gluconate transmembrane transporter activity
HUB98_RS02430	COG2084	Dehydrogenase
HUB98_RS02450	COG3711	transcriptional antiterminator
HUB98_RS02460	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUB98_RS02465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUB98_RS02475	COG3275	phosphorelay sensor kinase activity
HUB98_RS02480	COG2207	Transcriptional regulator
HUB98_RS02480	COG4753	response regulator
HUB98_RS02495	COG0395	ABC-type sugar transport system, permease component
HUB98_RS02515	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS02525	COG0673	inositol 2-dehydrogenase activity
HUB98_RS02530	COG0156	8-amino-7-oxononanoate synthase activity
HUB98_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUB98_RS02540	COG1595	DNA-templated transcription, initiation
HUB98_RS02555	COG1595	DNA-templated transcription, initiation
HUB98_RS02600	COG0583	DNA-binding transcription factor activity
HUB98_RS02620	COG2072	flavoprotein involved in K transport
HUB98_RS02625	COG0640	Transcriptional regulator
HUB98_RS02630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUB98_RS02635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUB98_RS02645	COG1714	RDD family
HUB98_RS02650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS02650	COG2207	Transcriptional regulator
HUB98_RS02690	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUB98_RS02700	COG0714	Associated with various cellular activities
HUB98_RS02705	COG2124	cytochrome p450
HUB98_RS02720	COG0028	Belongs to the TPP enzyme family
HUB98_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS02735	COG0254	rRNA binding
HUB98_RS02745	COG1063	alcohol dehydrogenase
HUB98_RS02760	COG2207	Transcriptional regulator
HUB98_RS02760	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS02765	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS02775	COG1802	Transcriptional regulator
HUB98_RS02780	COG1312	Catalyzes the dehydration of D-mannonate
HUB98_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS02790	COG2323	membrane
HUB98_RS02810	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUB98_RS02815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUB98_RS02820	COG1121	(ABC) transporter
HUB98_RS02830	COG0523	cobalamin synthesis protein
HUB98_RS02835	COG0701	Predicted permease
HUB98_RS02845	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUB98_RS02850	COG0813	purine-nucleoside phosphorylase activity
HUB98_RS02855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HUB98_RS02860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUB98_RS02865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUB98_RS02870	COG2390	Transcriptional regulator
HUB98_RS02875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUB98_RS02890	COG1070	Carbohydrate kinase
HUB98_RS02900	COG1609	Transcriptional regulator
HUB98_RS02915	COG0673	inositol 2-dehydrogenase activity
HUB98_RS02920	COG2169	Transcriptional regulator
HUB98_RS02945	COG1609	Transcriptional regulator
HUB98_RS02950	COG1494	fructose-1,6-bisphosphatase
HUB98_RS02965	COG2080	2 iron, 2 sulfur cluster binding
HUB98_RS02970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUB98_RS02980	COG2068	MobA-Related Protein
HUB98_RS02985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUB98_RS02990	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS02995	COG0405	Gamma-glutamyltransferase
HUB98_RS03000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUB98_RS03005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUB98_RS03010	COG2351	hydroxyisourate hydrolase activity
HUB98_RS03015	COG3195	allantoin biosynthetic process
HUB98_RS03015	COG3648	Uricase
HUB98_RS03020	COG2508	Transcriptional regulator
HUB98_RS03025	COG0784	Response regulator, receiver
HUB98_RS03025	COG2205	protein histidine kinase activity
HUB98_RS03030	COG0114	fumarate hydratase activity
HUB98_RS03040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUB98_RS03050	COG2309	aminopeptidase activity
HUB98_RS03055	COG2309	aminopeptidase activity
HUB98_RS03075	COG1253	flavin adenine dinucleotide binding
HUB98_RS03090	COG3773	Cell wall hydrolase
HUB98_RS03145	COG0588	phosphoglycerate mutase activity
HUB98_RS03160	COG0039	L-malate dehydrogenase activity
HUB98_RS03170	COG4974	Belongs to the 'phage' integrase family
HUB98_RS03180	COG0531	amino acid
HUB98_RS03185	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS03195	COG0154	amidase activity
HUB98_RS03200	COG3665	Urea carboxylase-associated protein
HUB98_RS03205	COG1280	lysine exporter protein (LysE YggA)
HUB98_RS03210	COG3403	YqcI/YcgG family
HUB98_RS03215	COG1113	amino acid transport
HUB98_RS03220	COG2732	(Barnase) inhibitor
HUB98_RS03225	COG3223	Belongs to the PsiE family
HUB98_RS03230	COG5002	protein histidine kinase activity
HUB98_RS03230	COG0642	Histidine kinase
HUB98_RS03235	COG0745	RESPONSE REGULATOR receiver
HUB98_RS03240	COG2311	Membrane
HUB98_RS03245	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS03260	COG1763	Mo-molybdopterin cofactor biosynthetic process
HUB98_RS03265	COG0303	'Molybdopterin
HUB98_RS03270	COG1403	HNH endonuclease
HUB98_RS03290	COG1842	Phage shock protein A
HUB98_RS03305	COG1388	LysM domain
HUB98_RS03305	COG3584	3D domain protein
HUB98_RS03315	COG1126	abc transporter atp-binding protein
HUB98_RS03320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS03330	COG0297	glycogen (starch) synthase activity
HUB98_RS03335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUB98_RS03340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUB98_RS03350	COG0745	RESPONSE REGULATOR receiver
HUB98_RS03365	COG0477	Major facilitator Superfamily
HUB98_RS03385	COG0735	belongs to the Fur family
HUB98_RS03390	COG0493	'glutamate synthase
HUB98_RS03395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUB98_RS03400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUB98_RS03410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB98_RS03415	COG0022	dehydrogenase e1 component
HUB98_RS03430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUB98_RS03435	COG2860	membrane
HUB98_RS03440	COG1564	THIamine pyrophosphokinase
HUB98_RS03450	COG0745	RESPONSE REGULATOR receiver
HUB98_RS03455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUB98_RS03460	COG2022	thiamine diphosphate biosynthetic process
HUB98_RS03470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUB98_RS03480	COG0488	(ABC) transporter
HUB98_RS03530	COG0515	serine threonine protein kinase
HUB98_RS03535	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HUB98_RS03540	COG1119	ATPase activity
HUB98_RS03545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS03555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUB98_RS03560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUB98_RS03565	COG0647	UMP catabolic process
HUB98_RS03570	COG1234	tRNA 3'-trailer cleavage
HUB98_RS03575	COG1410	methionine synthase
HUB98_RS03575	COG0646	methionine synthase
HUB98_RS03580	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HUB98_RS03585	COG1802	Transcriptional regulator
HUB98_RS03590	COG1011	Hydrolase
HUB98_RS03610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUB98_RS03615	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS03655	COG0210	DNA helicase
HUB98_RS03660	COG3593	DNA synthesis involved in DNA repair
HUB98_RS03675	COG2135	peptidase activity
HUB98_RS03680	COG5492	domain, Protein
HUB98_RS03720	COG3344	reverse transcriptase
HUB98_RS03730	COG0714	Associated with various cellular activities
HUB98_RS03770	COG2003	Belongs to the UPF0758 family
HUB98_RS03790	COG0629	single-stranded DNA binding
HUB98_RS03830	COG1185	polyribonucleotide nucleotidyltransferase activity
HUB98_RS03830	COG0539	negative regulation of cytoplasmic translation
HUB98_RS03855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUB98_RS03875	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUB98_RS03930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUB98_RS03950	COG0739	heme binding
HUB98_RS03980	COG3437	response regulator, receiver
HUB98_RS03980	COG0784	Response regulator, receiver
HUB98_RS03990	COG2359	stage V sporulation protein S
HUB98_RS04025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUB98_RS04045	COG1396	sequence-specific DNA binding
HUB98_RS04065	COG2826	transposase and inactivated derivatives, IS30 family
HUB98_RS04105	COG0174	glutamine synthetase
HUB98_RS04110	COG0789	Transcriptional regulator
HUB98_RS04115	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HUB98_RS04120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUB98_RS04125	COG0464	growth
HUB98_RS04135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUB98_RS04140	COG1923	regulation of RNA biosynthetic process
HUB98_RS04145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUB98_RS04155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUB98_RS04160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUB98_RS04175	COG4129	membrane
HUB98_RS04180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUB98_RS04185	COG1116	anion transmembrane transporter activity
HUB98_RS04190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUB98_RS04195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUB98_RS04200	COG0288	reversible hydration of carbon dioxide
HUB98_RS04240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUB98_RS04250	COG1187	pseudouridine synthase activity
HUB98_RS04265	COG1063	alcohol dehydrogenase
HUB98_RS04270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUB98_RS04285	COG0561	phosphatase activity
HUB98_RS04300	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS04305	COG1263	PTS System
HUB98_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS04305	COG2190	(PTS) system
HUB98_RS04310	COG3711	transcriptional antiterminator
HUB98_RS04335	COG1408	metallophosphoesterase
HUB98_RS04340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUB98_RS04350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUB98_RS04355	COG0583	DNA-binding transcription factor activity
HUB98_RS04360	COG2198	Histidine kinase
HUB98_RS04360	COG0643	Histidine kinase
HUB98_RS04370	COG0840	transmembrane signaling receptor activity
HUB98_RS04410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUB98_RS04460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUB98_RS04490	COG2353	YceI-like domain
HUB98_RS04495	COG0745	RESPONSE REGULATOR receiver
HUB98_RS04500	COG5002	protein histidine kinase activity
HUB98_RS04505	COG0464	growth
HUB98_RS04515	COG2368	4-hydroxyphenylacetate
HUB98_RS04530	COG0716	FMN binding
HUB98_RS04535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUB98_RS04535	COG0116	Belongs to the methyltransferase superfamily
HUB98_RS04540	COG0564	pseudouridine synthase activity
HUB98_RS04545	COG3695	enzyme binding
HUB98_RS04550	COG2814	Major facilitator Superfamily
HUB98_RS04560	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUB98_RS04570	COG1846	Transcriptional regulator
HUB98_RS04575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUB98_RS04590	COG1131	(ABC) transporter
HUB98_RS04600	COG2340	Cysteine-rich secretory protein family
HUB98_RS04610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUB98_RS04620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS04630	COG1132	(ABC) transporter
HUB98_RS04635	COG1132	(ABC) transporter
HUB98_RS04640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUB98_RS04650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUB98_RS04665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUB98_RS04670	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUB98_RS04675	COG0066	3-isopropylmalate dehydratase activity
HUB98_RS04680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUB98_RS04685	COG0583	DNA-binding transcription factor activity
HUB98_RS04690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUB98_RS04695	COG0436	Aminotransferase
HUB98_RS04700	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUB98_RS04705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUB98_RS04715	COG1850	ribulose-bisphosphate carboxylase activity
HUB98_RS04720	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HUB98_RS04725	COG0235	Class ii aldolase
HUB98_RS04745	COG3935	DnaD domain protein
HUB98_RS04750	COG0017	Asparaginyl-tRNA synthetase
HUB98_RS04755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUB98_RS04760	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUB98_RS04765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUB98_RS04780	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS04785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUB98_RS04790	COG1199	ATP-dependent helicase activity
HUB98_RS04790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUB98_RS04800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUB98_RS04805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUB98_RS04810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUB98_RS04820	COG0617	tRNA 3'-terminal CCA addition
HUB98_RS04825	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS04830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUB98_RS04835	COG1803	Methylglyoxal synthase
HUB98_RS04840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUB98_RS04850	COG1694	Mazg nucleotide pyrophosphohydrolase
HUB98_RS04855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS04865	COG4347	Protein of unknown function (DUF1405)
HUB98_RS04870	COG2010	Cytochrome c
HUB98_RS04870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUB98_RS04905	COG0406	alpha-ribazole phosphatase activity
HUB98_RS04920	COG0287	Prephenate dehydrogenase
HUB98_RS04925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUB98_RS04930	COG0159	tryptophan synthase activity
HUB98_RS04940	COG0135	phosphoribosylanthranilate isomerase activity
HUB98_RS04945	COG0134	indole-3-glycerol-phosphate synthase activity
HUB98_RS04950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUB98_RS04960	COG4401	Chorismate mutase type I
HUB98_RS04965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUB98_RS04970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUB98_RS04975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUB98_RS04980	COG0105	UTP biosynthetic process
HUB98_RS04995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUB98_RS05000	COG2226	methyltransferase
HUB98_RS05025	COG0776	regulation of translation
HUB98_RS05030	COG4211	Belongs to the binding-protein-dependent transport system permease family
HUB98_RS05035	COG1129	ABC transporter
HUB98_RS05045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HUB98_RS05080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUB98_RS05085	COG1160	GTP binding
HUB98_RS05090	COG0539	negative regulation of cytoplasmic translation
HUB98_RS05095	COG0204	Acyl-transferase
HUB98_RS05100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUB98_RS05115	COG2959	enzyme of heme biosynthesis
HUB98_RS05125	COG2339	peptidase activity
HUB98_RS05130	COG4862	establishment of competence for transformation
HUB98_RS05140	COG1408	metallophosphoesterase
HUB98_RS05155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUB98_RS05165	COG5002	protein histidine kinase activity
HUB98_RS05170	COG0745	RESPONSE REGULATOR receiver
HUB98_RS05175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUB98_RS05180	COG1333	cytochrome c biogenesis protein
HUB98_RS05185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS05190	COG1187	pseudouridine synthase activity
HUB98_RS05195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS05200	COG0700	Nucleoside recognition
HUB98_RS05205	COG2715	membrane protein required for spore maturation
HUB98_RS05210	COG1686	Belongs to the peptidase S11 family
HUB98_RS05215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUB98_RS05220	COG0741	lytic transglycosylase activity
HUB98_RS05375	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS05410	COG4824	toxin secretion phage lysis holin
HUB98_RS05415	COG3874	Sporulation protein YtfJ
HUB98_RS05435	COG0587	DNA-directed DNA polymerase activity
HUB98_RS05440	COG0464	growth
HUB98_RS05530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUB98_RS05545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUB98_RS05550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUB98_RS05655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUB98_RS05725	COG1793	dna ligase
HUB98_RS05830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUB98_RS05845	COG4474	Belongs to the UPF0398 family
HUB98_RS06140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUB98_RS06265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUB98_RS06400	COG0582	viral genome integration into host DNA
HUB98_RS06410	COG0739	heme binding
HUB98_RS06410	COG0741	lytic transglycosylase activity
HUB98_RS06410	COG1196	nuclear chromosome segregation
HUB98_RS06420	COG0741	lytic transglycosylase activity
HUB98_RS06420	COG1196	nuclear chromosome segregation
HUB98_RS06420	COG0739	heme binding
HUB98_RS06425	COG2433	Pfam Transposase IS66
HUB98_RS06530	COG4824	toxin secretion phage lysis holin
HUB98_RS06565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUB98_RS06575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUB98_RS06575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUB98_RS06585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUB98_RS06585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUB98_RS06595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUB98_RS06600	COG0019	diaminopimelate decarboxylase activity
HUB98_RS06605	COG0697	spore germination
HUB98_RS06630	COG2172	sigma factor antagonist activity
HUB98_RS06635	COG1366	Belongs to the anti-sigma-factor antagonist family
HUB98_RS06640	COG1686	Belongs to the peptidase S11 family
HUB98_RS06650	COG4974	Belongs to the 'phage' integrase family
HUB98_RS06660	COG0735	belongs to the Fur family
HUB98_RS06665	COG1300	Membrane
HUB98_RS06670	COG1379	DNA repair
HUB98_RS06675	COG0494	nUDIX hydrolase
HUB98_RS06685	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUB98_RS06695	COG0321	lipoyl(octanoyl) transferase activity
HUB98_RS06700	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB98_RS06705	COG0022	dehydrogenase e1 component
HUB98_RS06710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUB98_RS06715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUB98_RS06760	COG0745	RESPONSE REGULATOR receiver
HUB98_RS06765	COG0750	zinc metalloprotease
HUB98_RS06770	COG0497	DNA recombination
HUB98_RS06775	COG1438	arginine binding
HUB98_RS06785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUB98_RS06790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUB98_RS06800	COG1722	exodeoxyribonuclease VII activity
HUB98_RS06805	COG1570	exodeoxyribonuclease VII activity
HUB98_RS06810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUB98_RS06815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUB98_RS06830	COG1302	Protein conserved in bacteria
HUB98_RS06835	COG0439	Biotin carboxylase
HUB98_RS06840	COG0511	ligase activity, forming carbon-carbon bonds
HUB98_RS06880	COG3854	ATPases associated with a variety of cellular activities
HUB98_RS06890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUB98_RS06895	COG0006	proline dipeptidase activity
HUB98_RS06900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUB98_RS06910	COG3872	metal-dependent enzyme
HUB98_RS06920	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUB98_RS06925	COG1649	PFAM Uncharacterised BCR, COG1649
HUB98_RS06930	COG1321	iron dependent repressor
HUB98_RS06935	COG1533	DNA photolyase activity
HUB98_RS06940	COG0785	Cytochrome C biogenesis protein
HUB98_RS06945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUB98_RS06950	COG1121	(ABC) transporter
HUB98_RS06960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUB98_RS06960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUB98_RS06965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUB98_RS06970	COG0735	belongs to the Fur family
HUB98_RS06980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUB98_RS06985	COG1882	Formate acetyltransferase
HUB98_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS06995	COG1454	alcohol dehydrogenase
HUB98_RS07000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUB98_RS07015	COG1733	regulation of RNA biosynthetic process
HUB98_RS07045	COG0673	inositol 2-dehydrogenase activity
HUB98_RS07055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUB98_RS07055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUB98_RS07065	COG4876	unkown
HUB98_RS07070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS07090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUB98_RS07095	COG1199	ATP-dependent helicase activity
HUB98_RS07130	COG3022	response to hydroperoxide
HUB98_RS07245	COG2826	transposase and inactivated derivatives, IS30 family
HUB98_RS07270	COG0477	Major facilitator Superfamily
HUB98_RS07275	COG0395	ABC-type sugar transport system, permease component
HUB98_RS07280	COG1175	transmembrane transport
HUB98_RS07285	COG1653	transport
HUB98_RS07290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS07295	COG2207	Transcriptional regulator
HUB98_RS07295	COG0662	Cupin 2, conserved barrel domain protein
HUB98_RS07320	COG0745	RESPONSE REGULATOR receiver
HUB98_RS07325	COG1215	transferase activity, transferring glycosyl groups
HUB98_RS07340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUB98_RS07350	COG2066	Belongs to the glutaminase family
HUB98_RS07365	COG2223	nitrite transmembrane transporter activity
HUB98_RS07370	COG3279	Response regulator of the LytR AlgR family
HUB98_RS07375	COG3275	phosphorelay sensor kinase activity
HUB98_RS07385	COG0395	ABC-type sugar transport system, permease component
HUB98_RS07390	COG1175	transmembrane transport
HUB98_RS07400	COG2972	Histidine kinase
HUB98_RS07420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUB98_RS07425	COG1307	EDD domain protein, DegV family
HUB98_RS07430	COG1461	Dihydroxyacetone kinase
HUB98_RS07440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUB98_RS07460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUB98_RS07465	COG1162	GTPase activity
HUB98_RS07470	COG2815	serine threonine protein kinase
HUB98_RS07470	COG0515	serine threonine protein kinase
HUB98_RS07475	COG0631	protein serine/threonine phosphatase activity
HUB98_RS07480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUB98_RS07485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUB98_RS07485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUB98_RS07495	COG0242	peptide deformylase activity
HUB98_RS07500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUB98_RS07505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUB98_RS07510	COG1758	RNA polymerase activity
HUB98_RS07515	COG0194	GDP metabolic process
HUB98_RS07520	COG2052	Domain of unknown function (DUF370)
HUB98_RS07525	COG1561	YicC-like family, N-terminal region
HUB98_RS07530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUB98_RS07530	COG0646	methionine synthase
HUB98_RS07535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUB98_RS07540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUB98_RS07545	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUB98_RS07555	COG0583	DNA-binding transcription factor activity
HUB98_RS07565	COG4471	UPF0298 protein
HUB98_RS07585	COG1473	amidohydrolase
HUB98_RS07595	COG0772	Belongs to the SEDS family
HUB98_RS07605	COG0387	Pfam Sodium calcium exchanger
HUB98_RS07610	COG4838	Belongs to the UPF0358 family
HUB98_RS07620	COG2309	aminopeptidase activity
HUB98_RS07630	COG2203	Gaf domain
HUB98_RS07630	COG2199	diguanylate cyclase activity
HUB98_RS07635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUB98_RS07650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUB98_RS07655	COG0454	-acetyltransferase
HUB98_RS07660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUB98_RS07665	COG1609	Transcriptional regulator
HUB98_RS07680	COG0693	protein deglycase activity
HUB98_RS07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUB98_RS07690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS07690	COG1263	PTS System
HUB98_RS07690	COG2190	(PTS) system
HUB98_RS07695	COG1832	CoA-binding protein
HUB98_RS07700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUB98_RS07705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUB98_RS07710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUB98_RS07715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUB98_RS07730	COG0477	Major facilitator Superfamily
HUB98_RS07735	COG1982	Orn Lys Arg decarboxylase major
HUB98_RS07740	COG3906	Belongs to the UPF0473 family
HUB98_RS07760	COG1764	response to oxidative stress
HUB98_RS07780	COG2153	protein acetylation
HUB98_RS07810	COG3546	catalase activity
HUB98_RS07820	COG1132	(ABC) transporter
HUB98_RS07825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS07830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS07835	COG0584	glycerophosphoryl diester phosphodiesterase
HUB98_RS07845	COG1611	Belongs to the LOG family
HUB98_RS07855	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUB98_RS07860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUB98_RS07900	COG3209	COG3209 Rhs family protein
HUB98_RS07905	COG2205	protein histidine kinase activity
HUB98_RS07905	COG0784	Response regulator, receiver
HUB98_RS07965	COG1136	(ABC) transporter
HUB98_RS07975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUB98_RS07980	COG1136	(ABC) transporter
HUB98_RS08005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUB98_RS08010	COG0540	Belongs to the ATCase OTCase family
HUB98_RS08015	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUB98_RS08050	COG0436	Aminotransferase
HUB98_RS08055	COG0564	pseudouridine synthase activity
HUB98_RS08060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUB98_RS08065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUB98_RS08080	COG3599	regulation of cell shape
HUB98_RS08085	COG2302	S4 RNA-binding domain
HUB98_RS08090	COG0762	integral membrane protein
HUB98_RS08095	COG1799	cell septum assembly
HUB98_RS08100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUB98_RS08110	COG1873	PFAM PRC-barrel domain
HUB98_RS08115	COG1191	sigma factor activity
HUB98_RS08120	COG1191	sigma factor activity
HUB98_RS08130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUB98_RS08135	COG0849	cell division
HUB98_RS08140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUB98_RS08145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUB98_RS08150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUB98_RS08155	COG0772	Belongs to the SEDS family
HUB98_RS08160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUB98_RS08165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUB98_RS08170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUB98_RS08180	COG0768	penicillin binding
HUB98_RS08185	COG0768	penicillin binding
HUB98_RS08195	COG0275	rRNA processing
HUB98_RS08200	COG2001	Belongs to the MraZ family
HUB98_RS08205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUB98_RS08210	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HUB98_RS08215	COG4172	Belongs to the ABC transporter superfamily
HUB98_RS08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS08225	COG0601	transmembrane transport
HUB98_RS08230	COG4166	transmembrane transport
HUB98_RS08240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUB98_RS08270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUB98_RS08285	COG1316	TRANSCRIPTIONal
HUB98_RS08305	COG0861	Integral membrane protein TerC family
HUB98_RS08310	COG0861	Integral membrane protein TerC family
HUB98_RS08315	COG0301	tRNA thio-modification
HUB98_RS08320	COG1104	cysteine desulfurase activity
HUB98_RS08325	COG0741	lytic transglycosylase activity
HUB98_RS08355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS08360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS08370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUB98_RS08375	COG2384	SAM-dependent methyltransferase
HUB98_RS08385	COG0358	DNA primase activity
HUB98_RS08390	COG1671	Belongs to the UPF0178 family
HUB98_RS08395	COG0751	glycine-tRNA ligase activity
HUB98_RS08400	COG0752	glycyl-tRNA synthetase alpha subunit
HUB98_RS08410	COG1381	Involved in DNA repair and RecF pathway recombination
HUB98_RS08420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUB98_RS08430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUB98_RS08435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUB98_RS08440	COG1480	7TM receptor with intracellular HD hydrolase
HUB98_RS08445	COG1702	phosphate starvation-inducible protein PhoH
HUB98_RS08465	COG4864	UPF0365 protein
HUB98_RS08470	COG1030	water channel activity
HUB98_RS08475	COG1610	YqeY-like protein
HUB98_RS08480	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUB98_RS08485	COG0537	adenosine 5'-monophosphoramidase activity
HUB98_RS08495	COG0419	ATPase involved in DNA repair
HUB98_RS08500	COG0420	3'-5' exonuclease activity
HUB98_RS08505	COG1074	ATP-dependent DNA helicase activity
HUB98_RS08510	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HUB98_RS08520	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUB98_RS08530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUB98_RS08535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUB98_RS08540	COG1994	Peptidase M50
HUB98_RS08545	COG2264	protein methyltransferase activity
HUB98_RS08570	COG0443	Heat shock 70 kDa protein
HUB98_RS08580	COG1420	regulation of RNA biosynthetic process
HUB98_RS08585	COG2198	Histidine kinase
HUB98_RS08585	COG0784	Response regulator, receiver
HUB98_RS08585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS08585	COG2205	protein histidine kinase activity
HUB98_RS08590	COG0745	RESPONSE REGULATOR receiver
HUB98_RS08605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUB98_RS08610	COG0481	GTPase activity
HUB98_RS08630	COG0268	Binds directly to 16S ribosomal RNA
HUB98_RS08635	COG1466	dna polymerase III delta subunit
HUB98_RS08645	COG1595	DNA-templated transcription, initiation
HUB98_RS08655	COG0658	competence protein
HUB98_RS08655	COG2333	competence protein COMEC
HUB98_RS08665	COG1555	photosystem II stabilization
HUB98_RS08670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUB98_RS08675	COG0495	leucyl-tRNA aminoacylation
HUB98_RS08685	COG2226	methyltransferase
HUB98_RS08690	COG2996	Protein conserved in bacteria
HUB98_RS08695	COG0799	negative regulation of ribosome biogenesis
HUB98_RS08700	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUB98_RS08705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUB98_RS08710	COG1534	Rna-binding protein
HUB98_RS08715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUB98_RS08720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUB98_RS08725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUB98_RS08730	COG1305	Transglutaminase-like
HUB98_RS08740	COG0714	Associated with various cellular activities
HUB98_RS08750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUB98_RS08760	COG1363	Peptidase, m42
HUB98_RS08775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUB98_RS08780	COG2146	nitrite reductase [NAD(P)H] activity
HUB98_RS08785	COG2116	formate transmembrane transporter activity
HUB98_RS08795	COG2814	Major facilitator Superfamily
HUB98_RS08805	COG1136	(ABC) transporter
HUB98_RS08805	COG0577	efflux transmembrane transporter activity
HUB98_RS08815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUB98_RS08840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUB98_RS08845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUB98_RS08850	COG1960	acyl-CoA dehydrogenase activity
HUB98_RS08885	COG2815	serine threonine protein kinase
HUB98_RS08885	COG0515	serine threonine protein kinase
HUB98_RS08890	COG0596	Alpha beta hydrolase
HUB98_RS08895	COG3341	Caulimovirus viroplasmin
HUB98_RS08895	COG0328	RNA-DNA hybrid ribonuclease activity
HUB98_RS08900	COG2323	membrane
HUB98_RS08905	COG1120	ATPase activity
HUB98_RS08910	COG4139	cobalamin transport
HUB98_RS08920	COG1846	Transcriptional regulator
HUB98_RS08930	COG1113	amino acid transport
HUB98_RS08965	COG2826	transposase and inactivated derivatives, IS30 family
HUB98_RS08975	COG4824	toxin secretion phage lysis holin
HUB98_RS09090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HUB98_RS09105	COG5518	Phage portal protein
HUB98_RS09175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUB98_RS09200	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HUB98_RS09215	COG0305	Participates in initiation and elongation during chromosome replication
HUB98_RS09225	COG1522	sequence-specific DNA binding
HUB98_RS09345	COG2382	esterase
HUB98_RS09345	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS09345	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS09355	COG2814	Major facilitator Superfamily
HUB98_RS09360	COG1397	ADP-ribosylglycohydrolase
HUB98_RS09365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUB98_RS09370	COG0246	Mannitol dehydrogenase
HUB98_RS09420	COG1361	Conserved repeat domain
HUB98_RS09490	COG1361	Conserved repeat domain
HUB98_RS09500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS09510	COG0596	Alpha beta hydrolase
HUB98_RS09520	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS09525	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS09540	COG0840	transmembrane signaling receptor activity
HUB98_RS09545	COG0436	Aminotransferase
HUB98_RS09565	COG5002	protein histidine kinase activity
HUB98_RS09570	COG0745	RESPONSE REGULATOR receiver
HUB98_RS09575	COG2190	(PTS) system
HUB98_RS09575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS09575	COG1263	PTS System
HUB98_RS09580	COG1151	hydroxylamine reductase activity
HUB98_RS09585	COG2814	Major facilitator Superfamily
HUB98_RS09600	COG3420	alginic acid biosynthetic process
HUB98_RS09620	COG4978	Transcriptional regulator
HUB98_RS09620	COG0789	Transcriptional regulator
HUB98_RS09635	COG2272	Belongs to the type-B carboxylesterase lipase family
HUB98_RS09640	COG1785	Belongs to the alkaline phosphatase family
HUB98_RS09660	COG0840	transmembrane signaling receptor activity
HUB98_RS09660	COG3290	protein histidine kinase activity
HUB98_RS09700	COG2190	(PTS) system
HUB98_RS09700	COG1263	PTS System
HUB98_RS09700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS09705	COG3711	transcriptional antiterminator
HUB98_RS09715	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS09735	COG4172	Belongs to the ABC transporter superfamily
HUB98_RS09745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS09760	COG4305	rare lipoprotein A
HUB98_RS09765	COG0475	glutathione-regulated potassium exporter activity
HUB98_RS09770	COG0490	domain, Protein
HUB98_RS09780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUB98_RS09790	COG1357	PFAM Pentapeptide repeats (8 copies)
HUB98_RS09810	COG0708	Exodeoxyribonuclease III
HUB98_RS09825	COG3940	Belongs to the glycosyl hydrolase 43 family
HUB98_RS09840	COG0395	ABC-type sugar transport system, permease component
HUB98_RS09845	COG1175	transmembrane transport
HUB98_RS09855	COG1609	Transcriptional regulator
HUB98_RS09870	COG0840	transmembrane signaling receptor activity
HUB98_RS09885	COG0586	Pfam SNARE associated Golgi protein
HUB98_RS09920	COG0443	Heat shock 70 kDa protein
HUB98_RS09935	COG1309	transcriptional regulator
HUB98_RS09955	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HUB98_RS09965	COG2378	regulation of single-species biofilm formation
HUB98_RS09970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUB98_RS09975	COG0581	inorganic phosphate transmembrane transporter activity
HUB98_RS09980	COG0573	inorganic phosphate transmembrane transporter activity
HUB98_RS09995	COG3279	Response regulator of the LytR AlgR family
HUB98_RS10000	COG0745	RESPONSE REGULATOR receiver
HUB98_RS10000	COG2972	Histidine kinase
HUB98_RS10025	COG0395	ABC-type sugar transport system, permease component
HUB98_RS10030	COG4209	transmembrane transport
HUB98_RS10040	COG2204	response regulator
HUB98_RS10045	COG2972	Histidine kinase
HUB98_RS10050	COG4753	response regulator
HUB98_RS10050	COG2207	Transcriptional regulator
HUB98_RS10070	COG2318	DinB family
HUB98_RS10095	COG0592	DNA-directed DNA polymerase activity
HUB98_RS10120	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS10135	COG2239	Acts as a magnesium transporter
HUB98_RS10140	COG4214	carbohydrate transport
HUB98_RS10150	COG4213	ABC transporter substrate-binding protein
HUB98_RS10155	COG4753	response regulator
HUB98_RS10155	COG2207	Transcriptional regulator
HUB98_RS10160	COG2972	Histidine kinase
HUB98_RS10180	COG0671	phosphoesterase, PA-phosphatase related
HUB98_RS10185	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS10190	COG2378	regulation of single-species biofilm formation
HUB98_RS10220	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUB98_RS10240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUB98_RS10250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUB98_RS10260	COG0861	Integral membrane protein TerC family
HUB98_RS10265	COG2814	Major facilitator Superfamily
HUB98_RS10270	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS10290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUB98_RS10295	COG1523	belongs to the glycosyl hydrolase 13 family
HUB98_RS10300	COG1523	belongs to the glycosyl hydrolase 13 family
HUB98_RS10305	COG1653	transport
HUB98_RS10310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUB98_RS10315	COG1653	transport
HUB98_RS10320	COG0395	ABC-type sugar transport system, permease component
HUB98_RS10325	COG4209	transmembrane transport
HUB98_RS10330	COG2207	Transcriptional regulator
HUB98_RS10340	COG0246	Mannitol dehydrogenase
HUB98_RS10345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUB98_RS10350	COG3711	transcriptional antiterminator
HUB98_RS10360	COG0509	glycine decarboxylation via glycine cleavage system
HUB98_RS10365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUB98_RS10370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUB98_RS10375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUB98_RS10390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUB98_RS10390	COG2190	(PTS) system
HUB98_RS10390	COG1263	PTS System
HUB98_RS10395	COG3711	transcriptional antiterminator
HUB98_RS10400	COG2268	Band 7 protein
HUB98_RS10410	COG1979	alcohol dehydrogenase
HUB98_RS10420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUB98_RS10425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUB98_RS10430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUB98_RS10440	COG0667	Aldo Keto reductase
HUB98_RS10445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUB98_RS10450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUB98_RS10460	COG0800	Aldolase
HUB98_RS10470	COG3594	Acyltransferase
HUB98_RS10480	COG0129	dihydroxy-acid dehydratase activity
HUB98_RS10495	COG0768	penicillin binding
HUB98_RS10500	COG0840	transmembrane signaling receptor activity
HUB98_RS10515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUB98_RS10525	COG3906	Belongs to the UPF0473 family
HUB98_RS10545	COG0628	permease
HUB98_RS10560	COG1104	cysteine desulfurase activity
HUB98_RS10565	COG1959	2 iron, 2 sulfur cluster binding
HUB98_RS10570	COG0482	sulfurtransferase activity
HUB98_RS10575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUB98_RS10580	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUB98_RS10585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUB98_RS10590	COG0583	DNA-binding transcription factor activity
HUB98_RS10595	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS10605	COG3973	AAA domain
HUB98_RS10610	COG1132	(ABC) transporter
HUB98_RS10620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUB98_RS10625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUB98_RS10630	COG0124	histidyl-tRNA synthetase
HUB98_RS10640	COG0693	protein deglycase activity
HUB98_RS10650	COG1490	D-aminoacyl-tRNA deacylase activity
HUB98_RS10655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUB98_RS10665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUB98_RS10670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUB98_RS10670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUB98_RS10675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUB98_RS10680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUB98_RS10680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUB98_RS10685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUB98_RS10685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUB98_RS10695	COG2244	polysaccharide biosynthetic process
HUB98_RS10700	COG2323	membrane
HUB98_RS10710	COG1862	Preprotein translocase
HUB98_RS10725	COG2385	sporulation resulting in formation of a cellular spore
HUB98_RS10730	COG2255	four-way junction helicase activity
HUB98_RS10735	COG0632	four-way junction helicase activity
HUB98_RS10740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUB98_RS10820	COG0077	Prephenate dehydratase
HUB98_RS10825	COG0083	homoserine kinase activity
HUB98_RS10830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUB98_RS10835	COG0460	homoserine dehydrogenase
HUB98_RS10840	COG4492	Belongs to the UPF0735 family
HUB98_RS10845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUB98_RS10855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUB98_RS10860	COG2868	ribosomal protein
HUB98_RS10865	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUB98_RS10870	COG1530	ribonuclease E activity
HUB98_RS10875	COG1994	Peptidase M50
HUB98_RS10880	COG0739	heme binding
HUB98_RS10885	COG2894	cell division
HUB98_RS10890	COG0850	regulation of cytokinetic process
HUB98_RS10905	COG1077	Cell shape determining protein MreB Mrl
HUB98_RS10910	COG2003	Belongs to the UPF0758 family
HUB98_RS10915	COG0424	maF-like protein
HUB98_RS10930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUB98_RS10940	COG0525	valine-tRNA ligase activity
HUB98_RS10945	COG1388	LysM domain
HUB98_RS10950	COG0564	pseudouridine synthase activity
HUB98_RS10955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUB98_RS10960	COG0113	porphobilinogen synthase activity
HUB98_RS10975	COG1648	precorrin-2 dehydrogenase activity
HUB98_RS10975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUB98_RS10990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUB98_RS11000	COG1067	ATP-dependent peptidase activity
HUB98_RS11000	COG0470	DNA polymerase III
HUB98_RS11010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUB98_RS11015	COG0740	serine-type endopeptidase activity
HUB98_RS11020	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUB98_RS11035	COG2807	transmembrane transport
HUB98_RS11040	COG1404	Belongs to the peptidase S8 family
HUB98_RS11045	COG2226	methyltransferase
HUB98_RS11070	COG0367	asparagine synthase
HUB98_RS11075	COG0840	transmembrane signaling receptor activity
HUB98_RS11105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUB98_RS11110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUB98_RS11115	COG5401	PFAM Sporulation and spore germination
HUB98_RS11120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUB98_RS11140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUB98_RS11150	COG1801	Protein of unknown function DUF72
HUB98_RS11155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUB98_RS11165	COG4716	Myosin-crossreactive antigen
HUB98_RS11170	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS11180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUB98_RS11190	COG1737	Transcriptional regulator
HUB98_RS11195	COG2197	response regulator
HUB98_RS11220	COG1131	(ABC) transporter
HUB98_RS11230	COG2814	Major facilitator Superfamily
HUB98_RS11240	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS11260	COG1216	Glycosyl transferase, family 2
HUB98_RS11270	COG1216	Glycosyl transferase, family 2
HUB98_RS11285	COG1086	Polysaccharide biosynthesis protein
HUB98_RS11300	COG4641	Protein conserved in bacteria
HUB98_RS11330	COG1126	abc transporter atp-binding protein
HUB98_RS11335	COG0765	amino acid transport
HUB98_RS11340	COG0765	amino acid transport
HUB98_RS11345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS11355	COG4149	molybdate abc transporter
HUB98_RS11360	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUB98_RS11365	COG1910	domain protein
HUB98_RS11375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUB98_RS11380	COG0523	cobalamin synthesis protein
HUB98_RS11395	COG1124	(ABC) transporter
HUB98_RS11400	COG0444	Belongs to the ABC transporter superfamily
HUB98_RS11405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS11410	COG0601	transmembrane transport
HUB98_RS11415	COG0747	negative chemotaxis
HUB98_RS11435	COG1473	amidohydrolase
HUB98_RS11440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS11445	COG0583	DNA-binding transcription factor activity
HUB98_RS11450	COG0431	NADPH-dependent FMN reductase
HUB98_RS11470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS11475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUB98_RS11490	COG1215	transferase activity, transferring glycosyl groups
HUB98_RS11500	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUB98_RS11505	COG1215	transferase activity, transferring glycosyl groups
HUB98_RS11515	COG0463	Glycosyl transferase, family 2
HUB98_RS11520	COG3227	Zinc metalloprotease (Elastase)
HUB98_RS11535	COG0688	phosphatidylethanolamine metabolic process
HUB98_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUB98_RS11565	COG1131	(ABC) transporter
HUB98_RS11575	COG0300	oxidoreductase activity
HUB98_RS11585	COG0583	DNA-binding transcription factor activity
HUB98_RS11590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUB98_RS11605	COG1408	metallophosphoesterase
HUB98_RS11610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUB98_RS11615	COG1053	succinate dehydrogenase
HUB98_RS11620	COG2009	succinate dehydrogenase
HUB98_RS11625	COG0583	DNA-binding transcription factor activity
HUB98_RS11630	COG0569	domain protein
HUB98_RS11635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUB98_RS11645	COG0322	excinuclease ABC activity
HUB98_RS11650	COG3118	belongs to the thioredoxin family
HUB98_RS11660	COG1484	DNA-dependent DNA replication
HUB98_RS11665	COG0383	alpha-mannosidase activity
HUB98_RS11690	COG0395	ABC-type sugar transport system, permease component
HUB98_RS11695	COG4209	transmembrane transport
HUB98_RS11705	COG4753	response regulator
HUB98_RS11705	COG2207	Transcriptional regulator
HUB98_RS11710	COG2972	Histidine kinase
HUB98_RS11735	COG1252	NADH dehydrogenase
HUB98_RS11755	COG0189	ligase activity
HUB98_RS11765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUB98_RS11765	COG0248	Ppx GppA phosphatase
HUB98_RS11770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUB98_RS11790	COG2211	Major facilitator Superfamily
HUB98_RS11800	COG2962	Rard protein
HUB98_RS11805	COG2910	NAD(P)H-binding
HUB98_RS11810	COG0316	Belongs to the HesB IscA family
HUB98_RS11815	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUB98_RS11820	COG1252	NADH dehydrogenase
HUB98_RS11830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HUB98_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS11845	COG1464	Belongs to the NlpA lipoprotein family
HUB98_RS11865	COG1612	heme a metabolic process
HUB98_RS11870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS11890	COG0561	phosphatase activity
HUB98_RS11895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUB98_RS11900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUB98_RS11900	COG1321	iron dependent repressor
HUB98_RS11905	COG1121	(ABC) transporter
HUB98_RS11910	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUB98_RS11940	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUB98_RS11950	COG1988	membrane-bound metal-dependent
HUB98_RS11965	COG0180	Tryptophanyl-tRNA synthetase
HUB98_RS11990	COG3093	addiction module antidote protein HigA
HUB98_RS12005	COG2346	COG2346, Truncated hemoglobins
HUB98_RS12010	COG3314	Sporulation integral membrane protein YlbJ
HUB98_RS12015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUB98_RS12020	COG4470	Protein conserved in bacteria
HUB98_RS12030	COG0739	heme binding
HUB98_RS12040	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUB98_RS12045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUB98_RS12050	COG1733	regulation of RNA biosynthetic process
HUB98_RS12075	COG4196	transglutaminase domain protein
HUB98_RS12100	COG4196	transglutaminase domain protein
HUB98_RS12125	COG1361	Conserved repeat domain
HUB98_RS12135	COG3209	COG3209 Rhs family protein
HUB98_RS12145	COG3209	COG3209 Rhs family protein
HUB98_RS12160	COG1361	Conserved repeat domain
HUB98_RS12170	COG3209	COG3209 Rhs family protein
HUB98_RS12210	COG1674	ftsk spoiiie
HUB98_RS12285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUB98_RS12290	COG0569	domain protein
HUB98_RS12300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUB98_RS12305	COG2259	Doxx family
HUB98_RS12310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUB98_RS12320	COG2197	response regulator
HUB98_RS12325	COG4585	Histidine kinase
HUB98_RS12335	COG1842	Phage shock protein A
HUB98_RS12360	COG2207	Transcriptional regulator
HUB98_RS12365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUB98_RS12380	COG1595	DNA-templated transcription, initiation
HUB98_RS12485	COG3858	chitin binding
HUB98_RS12490	COG0735	belongs to the Fur family
HUB98_RS12505	COG1285	pathogenesis
HUB98_RS12510	COG0456	acetyltransferase
HUB98_RS12510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUB98_RS12515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUB98_RS12520	COG0154	amidase activity
HUB98_RS12525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUB98_RS12545	COG1595	DNA-templated transcription, initiation
HUB98_RS12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUB98_RS12560	COG0586	Pfam SNARE associated Golgi protein
HUB98_RS12610	COG0671	phosphoesterase, PA-phosphatase related
HUB98_RS12625	COG0598	Magnesium transport protein CorA
HUB98_RS12630	COG1191	sigma factor activity
HUB98_RS12645	COG2205	protein histidine kinase activity
HUB98_RS12645	COG0784	Response regulator, receiver
HUB98_RS12650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUB98_RS12655	COG0784	Response regulator, receiver
HUB98_RS12655	COG5002	protein histidine kinase activity
HUB98_RS12655	COG2205	protein histidine kinase activity
HUB98_RS12660	COG2208	phosphoserine phosphatase activity
HUB98_RS12690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HUB98_RS12700	COG0488	(ABC) transporter
HUB98_RS12710	COG1294	oxidase, subunit
HUB98_RS12715	COG1271	oxidase subunit
HUB98_RS12720	COG5002	protein histidine kinase activity
HUB98_RS12725	COG0745	RESPONSE REGULATOR receiver
HUB98_RS12735	COG1413	lyase activity
HUB98_RS12740	COG0833	amino acid
HUB98_RS12755	COG0583	DNA-binding transcription factor activity
HUB98_RS12760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUB98_RS12775	COG1073	alpha beta
HUB98_RS12780	COG0800	Aldolase
HUB98_RS12785	COG0463	Glycosyl transferase, family 2
HUB98_RS12785	COG0457	Tetratricopeptide repeat
HUB98_RS12790	COG0463	Glycosyl transferase, family 2
HUB98_RS12795	COG1070	Carbohydrate kinase
HUB98_RS12800	COG2115	Belongs to the xylose isomerase family
HUB98_RS12815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUB98_RS12830	COG2267	carboxylic ester hydrolase activity
HUB98_RS12835	COG2217	Heavy metal translocating P-type atpase
HUB98_RS12855	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS12860	COG1349	DNA-binding transcription factor activity
HUB98_RS12865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HUB98_RS12885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUB98_RS12890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUB98_RS12900	COG2723	6-phospho-beta-galactosidase activity
HUB98_RS12920	COG0395	ABC-type sugar transport system, permease component
HUB98_RS12925	COG4209	transmembrane transport
HUB98_RS12935	COG2972	Histidine kinase
HUB98_RS12945	COG1126	abc transporter atp-binding protein
HUB98_RS12960	COG1309	transcriptional regulator
HUB98_RS12965	COG1968	undecaprenyl-diphosphatase activity
HUB98_RS12980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS12985	COG0667	Aldo Keto reductase
HUB98_RS12995	COG0588	phosphoglycerate mutase activity
HUB98_RS13000	COG2322	membrane
HUB98_RS13005	COG0475	glutathione-regulated potassium exporter activity
HUB98_RS13015	COG0586	Pfam SNARE associated Golgi protein
HUB98_RS13020	COG1183	phosphatidylcholine synthase activity
HUB98_RS13025	COG5002	protein histidine kinase activity
HUB98_RS13030	COG0745	RESPONSE REGULATOR receiver
HUB98_RS13035	COG0351	phosphomethylpyrimidine kinase
HUB98_RS13055	COG1131	(ABC) transporter
HUB98_RS13085	COG1733	regulation of RNA biosynthetic process
HUB98_RS13090	COG0778	Nitroreductase
HUB98_RS13125	COG0640	Transcriptional regulator
HUB98_RS13155	COG0667	Aldo Keto reductase
HUB98_RS13180	COG2040	homocysteine
HUB98_RS13185	COG0833	amino acid
HUB98_RS13195	COG0531	amino acid
HUB98_RS13200	COG0697	spore germination
HUB98_RS13220	COG1132	(ABC) transporter
HUB98_RS13225	COG1132	(ABC) transporter
HUB98_RS13255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUB98_RS13265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HUB98_RS13270	COG5662	AntiSigma factor
HUB98_RS13275	COG1595	DNA-templated transcription, initiation
HUB98_RS13280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUB98_RS13345	COG3935	DnaD domain protein
HUB98_RS13370	COG1396	sequence-specific DNA binding
HUB98_RS13375	COG0582	viral genome integration into host DNA
HUB98_RS13480	COG0726	polysaccharide deacetylase
HUB98_RS13495	COG0489	protein tyrosine kinase activity
HUB98_RS13500	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUB98_RS13505	COG2046	Belongs to the sulfate adenylyltransferase family
HUB98_RS13510	COG0175	sulfate reduction
HUB98_RS13515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUB98_RS13520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUB98_RS13525	COG0101	tRNA pseudouridine synthase activity
HUB98_RS13530	COG0203	ribosomal protein L17
HUB98_RS13535	COG0202	RNA polymerase activity
HUB98_RS13540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUB98_RS13545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUB98_RS13550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUB98_RS13555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUB98_RS13560	COG2163	COG2163 Ribosomal protein L14E L6E L27E
HUB98_RS13565	COG0024	Methionine aminopeptidase
HUB98_RS13570	COG0563	adenylate kinase activity
HUB98_RS13575	COG0201	protein transport
HUB98_RS13580	COG0200	Binds to the 23S rRNA
HUB98_RS13585	COG1841	ribosomal large subunit assembly
HUB98_RS13590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUB98_RS13595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUB98_RS13600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUB98_RS13610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUB98_RS13615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUB98_RS13620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUB98_RS13625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUB98_RS13630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUB98_RS13635	COG0255	Belongs to the universal ribosomal protein uL29 family
HUB98_RS13640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUB98_RS13645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUB98_RS13650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUB98_RS13655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUB98_RS13660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUB98_RS13665	COG0089	rRNA binding
HUB98_RS13670	COG0088	Forms part of the polypeptide exit tunnel
HUB98_RS13675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUB98_RS13685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUB98_RS13690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUB98_RS13695	COG0049	tRNA binding
HUB98_RS13700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUB98_RS13705	COG1358	cellular component organization or biogenesis
HUB98_RS13710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUB98_RS13715	COG0085	RNA polymerase activity
HUB98_RS13720	COG2813	Specifically methylates the guanine in position
HUB98_RS13725	COG0222	ribosome binding
HUB98_RS13730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUB98_RS13735	COG0081	regulation of translation
HUB98_RS13740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUB98_RS13745	COG0250	Participates in transcription elongation, termination and antitermination
HUB98_RS13750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUB98_RS13755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUB98_RS13765	COG3688	RNA-binding protein containing a PIN domain
HUB98_RS13770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUB98_RS13775	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUB98_RS13780	COG0215	cysteine-tRNA ligase activity
HUB98_RS13785	COG1045	serine acetyltransferase
HUB98_RS13790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUB98_RS13795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUB98_RS13800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUB98_RS13805	COG4956	integral membrane protein (PIN domain superfamily)
HUB98_RS13815	COG1183	phosphatidylcholine synthase activity
HUB98_RS13820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUB98_RS13825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUB98_RS13830	COG0542	response to heat
HUB98_RS13835	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HUB98_RS13840	COG3880	PFAM UvrB UvrC protein
HUB98_RS13880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUB98_RS13885	COG0210	DNA helicase
HUB98_RS13890	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HUB98_RS13900	COG1091	dTDP-4-dehydrorhamnose reductase activity
HUB98_RS13915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUB98_RS13920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUB98_RS13925	COG0826	peptidase U32
HUB98_RS13935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS13945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUB98_RS13950	COG0556	nucleotide-excision repair
HUB98_RS13955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUB98_RS13975	COG1131	(ABC) transporter
HUB98_RS13985	COG2197	response regulator
HUB98_RS13990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS13995	COG3409	Peptidoglycan-binding domain 1 protein
HUB98_RS13995	COG0793	Belongs to the peptidase S41A family
HUB98_RS14000	COG0739	heme binding
HUB98_RS14005	COG2177	Part of the ABC transporter FtsEX involved in
HUB98_RS14010	COG2884	Cell division ATP-binding protein ftsE
HUB98_RS14015	COG2720	vancomycin resistance protein
HUB98_RS14020	COG2814	Major facilitator Superfamily
HUB98_RS14025	COG1664	Polymer-forming cytoskeletal
HUB98_RS14030	COG0789	Transcriptional regulator
HUB98_RS14040	COG2508	Transcriptional regulator
HUB98_RS14045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUB98_RS14050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUB98_RS14055	COG2233	PERMEase
HUB98_RS14060	COG0154	amidase activity
HUB98_RS14065	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUB98_RS14075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUB98_RS14080	COG0165	Argininosuccinate lyase
HUB98_RS14085	COG0137	argininosuccinate synthase activity
HUB98_RS14090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUB98_RS14100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUB98_RS14105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUB98_RS14110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUB98_RS14115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUB98_RS14120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS14130	COG0653	protein targeting
HUB98_RS14135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUB98_RS14140	COG1278	Cold shock
HUB98_RS14150	COG1516	flagellar protein fliS
HUB98_RS14155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUB98_RS14175	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HUB98_RS14180	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HUB98_RS14190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUB98_RS14195	COG4786	Flagellar basal body rod
HUB98_RS14195	COG1256	bacterial-type flagellum assembly
HUB98_RS14215	COG1040	competence protein
HUB98_RS14225	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUB98_RS14240	COG4585	Histidine kinase
HUB98_RS14255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUB98_RS14290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUB98_RS14295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HUB98_RS14310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUB98_RS14315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUB98_RS14325	COG4786	Flagellar basal body rod
HUB98_RS14330	COG4786	Flagellar basal body rod
HUB98_RS14340	COG1609	Transcriptional regulator
HUB98_RS14345	COG0739	heme binding
HUB98_RS14350	COG2385	sporulation resulting in formation of a cellular spore
HUB98_RS14355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUB98_RS14360	COG4836	Membrane
HUB98_RS14365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUB98_RS14375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUB98_RS14380	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUB98_RS14385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUB98_RS14390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUB98_RS14400	COG0356	it plays a direct role in the translocation of protons across the membrane
HUB98_RS14415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUB98_RS14420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUB98_RS14425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUB98_RS14430	COG4475	Protein of unknown function (DUF436)
HUB98_RS14435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUB98_RS14440	COG1971	Probably functions as a manganese efflux pump
HUB98_RS14445	COG0009	L-threonylcarbamoyladenylate synthase
HUB98_RS14460	COG0772	Belongs to the SEDS family
HUB98_RS14470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUB98_RS14475	COG0012	GTP binding
HUB98_RS14480	COG0456	acetyltransferase
HUB98_RS14505	COG1304	FMN binding
HUB98_RS14560	COG2076	Multidrug Resistance protein
HUB98_RS14565	COG2076	Multidrug Resistance protein
HUB98_RS14570	COG1309	transcriptional regulator
HUB98_RS14575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUB98_RS14595	COG0167	dihydroorotate dehydrogenase activity
HUB98_RS14615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUB98_RS14620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUB98_RS14625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUB98_RS14630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUB98_RS14640	COG0840	transmembrane signaling receptor activity
HUB98_RS14650	COG0840	transmembrane signaling receptor activity
HUB98_RS14655	COG1279	arginine transmembrane transporter activity
HUB98_RS14660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS14665	COG0746	molybdenum cofactor guanylyltransferase activity
HUB98_RS14685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUB98_RS14700	COG0456	acetyltransferase
HUB98_RS14705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUB98_RS14710	COG3459	Glycosyltransferase 36 associated
HUB98_RS14720	COG2814	Major facilitator Superfamily
HUB98_RS14725	COG0243	molybdopterin cofactor binding
HUB98_RS14730	COG2116	formate transmembrane transporter activity
HUB98_RS14735	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUB98_RS14745	COG0386	Belongs to the glutathione peroxidase family
HUB98_RS14755	COG1120	ATPase activity
HUB98_RS14825	COG0659	secondary active sulfate transmembrane transporter activity
HUB98_RS14835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUB98_RS14880	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HUB98_RS14905	COG1587	Uroporphyrinogen-III synthase
HUB98_RS14925	COG0697	spore germination
HUB98_RS14935	COG1741	Belongs to the pirin family
HUB98_RS14940	COG2259	Doxx family
HUB98_RS14945	COG0501	Belongs to the peptidase M48B family
HUB98_RS14955	COG0753	catalase activity
HUB98_RS14960	COG0745	RESPONSE REGULATOR receiver
HUB98_RS14975	COG0667	Aldo Keto reductase
HUB98_RS14980	COG2205	protein histidine kinase activity
HUB98_RS14980	COG0784	Response regulator, receiver
HUB98_RS14995	COG0840	transmembrane signaling receptor activity
HUB98_RS15000	COG1472	Belongs to the glycosyl hydrolase 3 family
HUB98_RS15005	COG0723	plastoquinol--plastocyanin reductase activity
HUB98_RS15005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUB98_RS15010	COG1695	Transcriptional regulator
HUB98_RS15025	COG0300	oxidoreductase activity
HUB98_RS15040	COG3384	dioxygenase
HUB98_RS15055	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUB98_RS15070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUB98_RS15075	COG1177	transmembrane transport
HUB98_RS15080	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUB98_RS15085	COG3842	ATPase activity
HUB98_RS15100	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HUB98_RS15105	COG0783	Belongs to the Dps family
HUB98_RS15115	COG0672	)-iron permease
HUB98_RS15120	COG2837	iron assimilation
HUB98_RS15125	COG2822	iron ion transport
HUB98_RS15130	COG3064	Membrane
HUB98_RS15180	COG1597	lipid kinase activity
HUB98_RS15190	COG1132	(ABC) transporter
HUB98_RS15200	COG1846	Transcriptional regulator
HUB98_RS15205	COG1904	glucuronate isomerase
HUB98_RS15210	COG1234	tRNA 3'-trailer cleavage
HUB98_RS15225	COG1199	ATP-dependent helicase activity
HUB98_RS15230	COG2329	Antibiotic biosynthesis monooxygenase
HUB98_RS15245	COG0456	acetyltransferase
HUB98_RS15250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUB98_RS15250	COG3153	acetyltransferase
HUB98_RS15255	COG0583	DNA-binding transcription factor activity
HUB98_RS15260	COG1380	Effector of murein hydrolase LrgA
HUB98_RS15265	COG1346	cytolysis
HUB98_RS15270	COG2002	toxin-antitoxin pair type II binding
HUB98_RS15290	COG1733	regulation of RNA biosynthetic process
HUB98_RS15300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUB98_RS15305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUB98_RS15310	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HUB98_RS15315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUB98_RS15325	COG0640	Transcriptional regulator
HUB98_RS15335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUB98_RS15340	COG0395	ABC-type sugar transport system, permease component
HUB98_RS15345	COG1175	transmembrane transport
HUB98_RS15360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUB98_RS15365	COG4988	ABC transporter
HUB98_RS15370	COG1294	oxidase, subunit
HUB98_RS15375	COG1271	oxidase subunit
HUB98_RS15390	COG0297	glycogen (starch) synthase activity
HUB98_RS15400	COG0457	Tetratricopeptide repeat
HUB98_RS15400	COG0463	Glycosyl transferase, family 2
HUB98_RS15405	COG0463	Glycosyl transferase, family 2
HUB98_RS15405	COG0457	Tetratricopeptide repeat
HUB98_RS15440	COG1116	anion transmembrane transporter activity
HUB98_RS15475	COG5002	protein histidine kinase activity
HUB98_RS15480	COG0745	RESPONSE REGULATOR receiver
HUB98_RS15485	COG2207	Transcriptional regulator
HUB98_RS15495	COG0534	Mate efflux family protein
HUB98_RS15500	COG0395	ABC-type sugar transport system, permease component
HUB98_RS15520	COG2972	Histidine kinase
HUB98_RS15535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUB98_RS15545	COG3766	membrane
HUB98_RS15565	COG0488	(ABC) transporter
HUB98_RS15700	COG1124	(ABC) transporter
HUB98_RS15705	COG0444	Belongs to the ABC transporter superfamily
HUB98_RS15710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS15715	COG0601	transmembrane transport
HUB98_RS15720	COG0747	negative chemotaxis
HUB98_RS15730	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HUB98_RS15735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUB98_RS15745	COG1131	(ABC) transporter
HUB98_RS15760	COG5002	protein histidine kinase activity
HUB98_RS15760	COG3850	Histidine kinase
HUB98_RS15765	COG0745	RESPONSE REGULATOR receiver
HUB98_RS15770	COG0702	epimerase
HUB98_RS15775	COG1252	NADH dehydrogenase
HUB98_RS15785	COG1595	DNA-templated transcription, initiation
HUB98_RS15795	COG3237	CsbD-like
HUB98_RS15840	COG0415	Belongs to the DNA photolyase family
HUB98_RS15845	COG3279	Response regulator of the LytR AlgR family
HUB98_RS15850	COG0745	RESPONSE REGULATOR receiver
HUB98_RS15850	COG2972	Histidine kinase
HUB98_RS15855	COG1902	pentaerythritol trinitrate reductase activity
HUB98_RS15860	COG1942	4-Oxalocrotonate Tautomerase
HUB98_RS15865	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUB98_RS15875	COG0840	transmembrane signaling receptor activity
HUB98_RS15880	COG1115	amino acid carrier protein
HUB98_RS15885	COG0784	Response regulator, receiver
HUB98_RS15895	COG3401	FG-GAP repeat protein
HUB98_RS15905	COG1607	acyl-coa hydrolase
HUB98_RS15930	COG0745	RESPONSE REGULATOR receiver
HUB98_RS15955	COG0745	RESPONSE REGULATOR receiver
HUB98_RS15975	COG2271	Major facilitator Superfamily
HUB98_RS15980	COG0800	Aldolase
HUB98_RS15990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUB98_RS15995	COG1316	TRANSCRIPTIONal
HUB98_RS16000	COG0667	Aldo Keto reductase
HUB98_RS16005	COG1846	Transcriptional regulator
HUB98_RS16015	COG1733	regulation of RNA biosynthetic process
HUB98_RS16020	COG2814	Major facilitator Superfamily
HUB98_RS16025	COG0656	L-ascorbic acid biosynthetic process
HUB98_RS16030	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS16040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUB98_RS16045	COG1609	Transcriptional regulator
HUB98_RS16055	COG0395	ABC-type sugar transport system, permease component
HUB98_RS16060	COG4209	transmembrane transport
HUB98_RS16065	COG1119	ATPase activity
HUB98_RS16075	COG1215	transferase activity, transferring glycosyl groups
HUB98_RS16095	COG1846	Transcriptional regulator
HUB98_RS16100	COG2153	protein acetylation
HUB98_RS16105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUB98_RS16110	COG0733	neurotransmitter:sodium symporter activity
HUB98_RS16115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUB98_RS16130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS16155	COG4221	oxidoreductase activity
HUB98_RS16170	COG2226	methyltransferase
HUB98_RS16180	COG2824	Alkylphosphonate utilization operon protein PhnA
HUB98_RS16190	COG2272	Belongs to the type-B carboxylesterase lipase family
HUB98_RS16200	COG2076	Multidrug Resistance protein
HUB98_RS16205	COG0546	phosphoglycolate phosphatase activity
HUB98_RS16220	COG1175	transmembrane transport
HUB98_RS16225	COG1510	regulation of RNA biosynthetic process
HUB98_RS16230	COG2911	Protein conserved in bacteria
HUB98_RS16230	COG3266	domain, Protein
HUB98_RS16230	COG1361	Conserved repeat domain
HUB98_RS16245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUB98_RS16245	COG2169	Transcriptional regulator
HUB98_RS16265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUB98_RS16285	COG4989	oxidoreductase activity
HUB98_RS16295	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS16300	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS16305	COG0513	Belongs to the DEAD box helicase family
HUB98_RS16310	COG4977	sequence-specific DNA binding
HUB98_RS16315	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS16320	COG3940	Belongs to the glycosyl hydrolase 43 family
HUB98_RS16340	COG2894	cell division
HUB98_RS16345	COG0745	RESPONSE REGULATOR receiver
HUB98_RS16360	COG2378	regulation of single-species biofilm formation
HUB98_RS16375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUB98_RS16385	COG2755	lipolytic protein G-D-S-L family
HUB98_RS16385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HUB98_RS16395	COG1126	abc transporter atp-binding protein
HUB98_RS16400	COG0765	amino acid transport
HUB98_RS16405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS16410	COG0784	Response regulator, receiver
HUB98_RS16415	COG4191	Histidine kinase
HUB98_RS16420	COG2972	Histidine kinase
HUB98_RS16420	COG0745	RESPONSE REGULATOR receiver
HUB98_RS16425	COG3279	Response regulator of the LytR AlgR family
HUB98_RS16450	COG1361	Conserved repeat domain
HUB98_RS16455	COG2207	Transcriptional regulator
HUB98_RS16460	COG1653	transport
HUB98_RS16480	COG0579	oxidoreductase
HUB98_RS16490	COG0444	Belongs to the ABC transporter superfamily
HUB98_RS16500	COG0601	transmembrane transport
HUB98_RS16515	COG0302	gtp cyclohydrolase
HUB98_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS16545	COG1366	Belongs to the anti-sigma-factor antagonist family
HUB98_RS16565	COG5001	Diguanylate cyclase
HUB98_RS16580	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUB98_RS16585	COG2160	L-arabinose isomerase activity
HUB98_RS16590	COG0235	Class ii aldolase
HUB98_RS16600	COG1609	Transcriptional regulator
HUB98_RS16605	COG2205	protein histidine kinase activity
HUB98_RS16620	COG0745	RESPONSE REGULATOR receiver
HUB98_RS16620	COG2972	Histidine kinase
HUB98_RS16625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUB98_RS16655	COG2223	nitrite transmembrane transporter activity
HUB98_RS16675	COG1525	nuclease
HUB98_RS16675	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS16675	COG4085	toxin activity
HUB98_RS16710	COG1744	ABC transporter substrate-binding protein PnrA-like
HUB98_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS16725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUB98_RS16730	COG0488	(ABC) transporter
HUB98_RS16760	COG0789	Transcriptional regulator
HUB98_RS16840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS16850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUB98_RS16865	COG5002	protein histidine kinase activity
HUB98_RS16870	COG0745	RESPONSE REGULATOR receiver
HUB98_RS16875	COG0739	heme binding
HUB98_RS16885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUB98_RS16890	COG0305	Participates in initiation and elongation during chromosome replication
HUB98_RS16895	COG0359	binds to the 23S rRNA
HUB98_RS16900	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HUB98_RS16920	COG1316	TRANSCRIPTIONal
HUB98_RS16925	COG2814	Major facilitator Superfamily
HUB98_RS16935	COG1686	Belongs to the peptidase S11 family
HUB98_RS16945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS16950	COG0601	transmembrane transport
HUB98_RS16955	COG4608	Belongs to the ABC transporter superfamily
HUB98_RS16960	COG0444	Belongs to the ABC transporter superfamily
HUB98_RS16965	COG1876	peptidase activity
HUB98_RS16970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUB98_RS16975	COG0629	single-stranded DNA binding
HUB98_RS16980	COG0360	Binds together with S18 to 16S ribosomal RNA
HUB98_RS16995	COG4481	Protein conserved in bacteria
HUB98_RS17000	COG0668	transmembrane transport
HUB98_RS17020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUB98_RS17025	COG1475	DNA binding
HUB98_RS17030	COG1192	Involved in chromosome partitioning
HUB98_RS17035	COG1475	DNA binding
HUB98_RS17045	COG0445	tRNA wobble uridine modification
HUB98_RS17050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HUB98_RS17055	COG1847	R3H domain protein
HUB98_RS17060	COG0706	membrane insertase activity
HUB98_RS17065	COG0594	ribonuclease P activity
HUB98_RS17070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUB98_RS17085	COG1070	Carbohydrate kinase
HUB98_RS17090	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUB98_RS17095	COG0592	DNA-directed DNA polymerase activity
HUB98_RS17100	COG2501	S4 domain
HUB98_RS17105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUB98_RS17115	COG0187	DNA topoisomerase II activity
HUB98_RS17120	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUB98_RS17125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUB98_RS17130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUB98_RS17165	COG1982	Orn Lys Arg decarboxylase major
HUB98_RS17170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUB98_RS17175	COG3870	Protein conserved in bacteria
HUB98_RS17180	COG1728	Protein conserved in bacteria
HUB98_RS17185	COG0470	DNA polymerase III
HUB98_RS17190	COG1774	PSP1 C-terminal conserved region
HUB98_RS17195	COG4467	Involved in initiation control of chromosome replication
HUB98_RS17200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUB98_RS17205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUB98_RS17210	COG2002	toxin-antitoxin pair type II binding
HUB98_RS17215	COG1078	dGTPase activity
HUB98_RS17220	COG0084	hydrolase, TatD family'
HUB98_RS17225	COG3583	domain protein
HUB98_RS17225	COG3584	3D domain protein
HUB98_RS17235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUB98_RS17245	COG4466	Protein conserved in bacteria
HUB98_RS17255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUB98_RS17260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUB98_RS17265	COG2088	sporulation resulting in formation of a cellular spore
HUB98_RS17275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUB98_RS17295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUB98_RS17300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUB98_RS17305	COG2002	toxin-antitoxin pair type II binding
HUB98_RS17310	COG2244	polysaccharide biosynthetic process
HUB98_RS17315	COG3956	TIGRFAM MazG family protein
HUB98_RS17325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUB98_RS17345	COG1098	S1 RNA binding domain
HUB98_RS17350	COG2208	phosphoserine phosphatase activity
HUB98_RS17355	COG2304	oxidoreductase activity
HUB98_RS17360	COG0515	serine threonine protein kinase
HUB98_RS17375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUB98_RS17380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUB98_RS17385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUB98_RS17390	COG0157	Belongs to the NadC ModD family
HUB98_RS17395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUB98_RS17400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUB98_RS17405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUB98_RS17410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUB98_RS17415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUB98_RS17425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUB98_RS17430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUB98_RS17435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUB98_RS17440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUB98_RS17445	COG1396	sequence-specific DNA binding
HUB98_RS17450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUB98_RS17455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUB98_RS17470	COG3226	Transcriptional regulator
HUB98_RS17495	COG0516	GMP reductase activity
HUB98_RS17495	COG0517	IMP dehydrogenase activity
HUB98_RS17515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUB98_RS17545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUB98_RS17550	COG0590	tRNA wobble adenosine to inosine editing
HUB98_RS17555	COG5002	protein histidine kinase activity
HUB98_RS17560	COG1187	pseudouridine synthase activity
HUB98_RS17565	COG1360	Flagellar Motor Protein
HUB98_RS17570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUB98_RS17580	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUB98_RS17595	COG0791	NLP P60 protein
HUB98_RS17615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUB98_RS17620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HUB98_RS17625	COG0010	Belongs to the arginase family
HUB98_RS17640	COG3534	alpha-L-arabinofuranosidase
HUB98_RS17655	COG0018	arginyl-trna synthetase
HUB98_RS17665	COG3343	RNA polymerase activity
HUB98_RS17670	COG0504	CTP synthase activity
HUB98_RS17685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUB98_RS17690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HUB98_RS17700	COG0254	rRNA binding
HUB98_RS17710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUB98_RS17715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUB98_RS17720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUB98_RS17800	COG2508	Transcriptional regulator
HUB98_RS17805	COG3842	ATPase activity
HUB98_RS17810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUB98_RS17820	COG0546	phosphoglycolate phosphatase activity
HUB98_RS17825	COG0110	maltose O-acetyltransferase activity
HUB98_RS17830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HUB98_RS17835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUB98_RS17840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUB98_RS17845	COG0131	Imidazoleglycerol-phosphate dehydratase
HUB98_RS17850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUB98_RS17855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUB98_RS17860	COG0107	imidazoleglycerol-phosphate synthase activity
HUB98_RS17865	COG0140	phosphoribosyl-ATP diphosphatase activity
HUB98_RS17865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUB98_RS17870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUB98_RS17875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUB98_RS17880	COG2207	Transcriptional regulator
HUB98_RS17885	COG1653	transport
HUB98_RS17890	COG4209	transmembrane transport
HUB98_RS17895	COG0395	ABC-type sugar transport system, permease component
HUB98_RS17920	COG0628	permease
HUB98_RS17925	COG1940	carbohydrate kinase activity
HUB98_RS17930	COG1660	Displays ATPase and GTPase activities
HUB98_RS17935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUB98_RS17940	COG1481	regulation of sporulation
HUB98_RS17945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUB98_RS17960	COG0740	serine-type endopeptidase activity
HUB98_RS17980	COG0126	phosphoglycerate kinase activity
HUB98_RS17985	COG0149	triose-phosphate isomerase activity
HUB98_RS17990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUB98_RS17995	COG0148	phosphopyruvate hydratase activity
HUB98_RS18000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUB98_RS18005	COG0557	exoribonuclease II activity
HUB98_RS18010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUB98_RS18030	COG4185	zeta toxin
HUB98_RS18080	COG1175	transmembrane transport
HUB98_RS18085	COG0395	ABC-type sugar transport system, permease component
HUB98_RS18095	COG0778	Nitroreductase
HUB98_RS18105	COG0662	Cupin 2, conserved barrel domain protein
HUB98_RS18105	COG2207	Transcriptional regulator
HUB98_RS18120	COG0668	transmembrane transport
HUB98_RS18125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS18145	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS18145	COG2207	Transcriptional regulator
HUB98_RS18155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUB98_RS18170	COG3829	transcription factor binding
HUB98_RS18180	COG1842	Phage shock protein A
HUB98_RS18185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUB98_RS18190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUB98_RS18195	COG4260	virion core protein, lumpy skin disease virus
HUB98_RS18200	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS18205	COG4224	UPF0291 protein
HUB98_RS18210	COG0346	lactoylglutathione lyase activity
HUB98_RS18220	COG1472	Belongs to the glycosyl hydrolase 3 family
HUB98_RS18255	COG0673	inositol 2-dehydrogenase activity
HUB98_RS18265	COG4209	transmembrane transport
HUB98_RS18270	COG0395	ABC-type sugar transport system, permease component
HUB98_RS18280	COG2207	Transcriptional regulator
HUB98_RS18285	COG1472	Belongs to the glycosyl hydrolase 3 family
HUB98_RS18320	COG3118	belongs to the thioredoxin family
HUB98_RS18340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUB98_RS18345	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HUB98_RS18350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUB98_RS18360	COG2205	protein histidine kinase activity
HUB98_RS18365	COG0745	RESPONSE REGULATOR receiver
HUB98_RS18370	COG1942	4-Oxalocrotonate Tautomerase
HUB98_RS18375	COG5002	protein histidine kinase activity
HUB98_RS18380	COG0745	RESPONSE REGULATOR receiver
HUB98_RS18400	COG1486	melibiose metabolic process
HUB98_RS18415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUB98_RS18420	COG0747	negative chemotaxis
HUB98_RS18425	COG0444	Belongs to the ABC transporter superfamily
HUB98_RS18430	COG4172	Belongs to the ABC transporter superfamily
HUB98_RS18445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUB98_RS18450	COG0572	uridine kinase
HUB98_RS18465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUB98_RS18470	COG4715	Zinc finger, swim domain protein
HUB98_RS18480	COG0840	transmembrane signaling receptor activity
HUB98_RS18485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUB98_RS18495	COG1175	transmembrane transport
HUB98_RS18500	COG0395	ABC-type sugar transport system, permease component
HUB98_RS18505	COG2972	Histidine kinase
HUB98_RS18510	COG2197	response regulator
HUB98_RS18620	COG3962	Belongs to the TPP enzyme family
HUB98_RS18625	COG1082	Xylose isomerase domain protein TIM barrel
HUB98_RS18630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUB98_RS18635	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS18640	COG0673	inositol 2-dehydrogenase activity
HUB98_RS18645	COG3718	enzyme involved in inositol metabolism
HUB98_RS18650	COG1609	Transcriptional regulator
HUB98_RS18695	COG0469	pyruvate kinase activity
HUB98_RS18715	COG1278	Cold shock
HUB98_RS18730	COG2226	methyltransferase
HUB98_RS18735	COG1802	Transcriptional regulator
HUB98_RS18740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUB98_RS18745	COG0010	Belongs to the arginase family
HUB98_RS18870	COG1177	transmembrane transport
HUB98_RS18875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUB98_RS18880	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUB98_RS18885	COG1737	Transcriptional regulator
HUB98_RS18890	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUB98_RS18895	COG2971	BadF BadG BcrA BcrD
HUB98_RS18910	COG0395	ABC-type sugar transport system, permease component
HUB98_RS18915	COG3842	ATPase activity
HUB98_RS18925	COG3876	Protein conserved in bacteria
HUB98_RS18930	COG1472	Belongs to the glycosyl hydrolase 3 family
HUB98_RS18935	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS18940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HUB98_RS18945	COG0840	transmembrane signaling receptor activity
HUB98_RS18955	COG0840	transmembrane signaling receptor activity
HUB98_RS18995	COG4932	domain protein
HUB98_RS18995	COG5492	domain, Protein
HUB98_RS19000	COG2059	Chromate
HUB98_RS19005	COG2059	Chromate
HUB98_RS19010	COG1522	sequence-specific DNA binding
HUB98_RS19050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUB98_RS19070	COG4085	toxin activity
HUB98_RS19070	COG1525	nuclease
HUB98_RS19070	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS19105	COG2814	Major facilitator Superfamily
HUB98_RS19110	COG1309	transcriptional regulator
HUB98_RS19115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS19175	COG1122	ATPase activity
HUB98_RS19300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUB98_RS19305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUB98_RS19340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUB98_RS19360	COG0529	Catalyzes the synthesis of activated sulfate
HUB98_RS19400	COG2972	Histidine kinase
HUB98_RS19405	COG4753	response regulator
HUB98_RS19405	COG2207	Transcriptional regulator
HUB98_RS19425	COG0395	ABC-type sugar transport system, permease component
HUB98_RS19430	COG3976	FMN-binding domain protein
HUB98_RS19430	COG1053	succinate dehydrogenase
HUB98_RS19435	COG0765	amino acid transport
HUB98_RS19440	COG0765	amino acid transport
HUB98_RS19445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS19470	COG0656	L-ascorbic acid biosynthetic process
HUB98_RS19475	COG2733	membrane
HUB98_RS19495	COG4549	nuclear export factor GLE1
HUB98_RS19500	COG2372	response to copper ion
HUB98_RS19510	COG4585	Histidine kinase
HUB98_RS19555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUB98_RS19585	COG2608	mercury ion transmembrane transporter activity
HUB98_RS19590	COG2217	Heavy metal translocating P-type atpase
HUB98_RS19605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HUB98_RS19620	COG1309	transcriptional regulator
HUB98_RS19625	COG0778	Nitroreductase
HUB98_RS19630	COG0084	hydrolase, TatD family'
HUB98_RS19635	COG1116	anion transmembrane transporter activity
HUB98_RS19640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUB98_RS19650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUB98_RS19660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUB98_RS19665	COG5492	domain, Protein
HUB98_RS19665	COG4932	domain protein
HUB98_RS19700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUB98_RS19705	COG1984	allophanate hydrolase subunit 2
HUB98_RS19710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUB98_RS19720	COG3871	stress protein (general stress protein 26)
HUB98_RS19725	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS19730	COG5001	Diguanylate cyclase
HUB98_RS19730	COG4251	negative regulation of phosphorylation
HUB98_RS19730	COG3706	GGDEF domain
HUB98_RS19730	COG2203	Gaf domain
HUB98_RS19735	COG0840	transmembrane signaling receptor activity
HUB98_RS19740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HUB98_RS19745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUB98_RS19750	COG0573	inorganic phosphate transmembrane transporter activity
HUB98_RS19755	COG0581	inorganic phosphate transmembrane transporter activity
HUB98_RS19760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUB98_RS19780	COG5002	protein histidine kinase activity
HUB98_RS19795	COG1760	l-serine dehydratase
HUB98_RS19800	COG1760	l-serine dehydratase
HUB98_RS19815	COG2205	protein histidine kinase activity
HUB98_RS19850	COG0515	serine threonine protein kinase
HUB98_RS19855	COG0024	Methionine aminopeptidase
HUB98_RS19860	COG2130	NADP-dependent
HUB98_RS19865	COG4846	Membrane protein involved in cytochrome C biogenesis
HUB98_RS19875	COG0778	Nitroreductase
HUB98_RS19900	COG4208	sulfate ABC transporter
HUB98_RS19955	COG2910	NAD(P)H-binding
HUB98_RS19960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUB98_RS19960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUB98_RS19965	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS19970	COG0840	transmembrane signaling receptor activity
HUB98_RS19980	COG0405	Gamma-glutamyltransferase
HUB98_RS19985	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS19990	COG0346	lactoylglutathione lyase activity
HUB98_RS20010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUB98_RS20015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUB98_RS20020	COG0011	TIGRFAM Protein of
HUB98_RS20035	COG1595	DNA-templated transcription, initiation
HUB98_RS20050	COG2770	Histidine kinase
HUB98_RS20050	COG3437	response regulator, receiver
HUB98_RS20060	COG2205	protein histidine kinase activity
HUB98_RS20060	COG3437	response regulator, receiver
HUB98_RS20060	COG3850	Histidine kinase
HUB98_RS20060	COG4999	Histidine kinase
HUB98_RS20070	COG0702	epimerase
HUB98_RS20075	COG0251	oxidation-reduction process
HUB98_RS20090	COG2207	Transcriptional regulator
HUB98_RS20090	COG4753	response regulator
HUB98_RS20095	COG2972	Histidine kinase
HUB98_RS20110	COG2182	Extracellular solute-binding protein
HUB98_RS20125	COG0835	chemotaxis
HUB98_RS20130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUB98_RS20140	COG1876	peptidase activity
HUB98_RS20160	COG0673	inositol 2-dehydrogenase activity
HUB98_RS20200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUB98_RS20210	COG1970	mechanosensitive ion channel activity
HUB98_RS20215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUB98_RS20240	COG0024	Methionine aminopeptidase
HUB98_RS20260	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUB98_RS20265	COG3336	cytochrome c oxidase
HUB98_RS20290	COG1725	Transcriptional regulator
HUB98_RS20295	COG1131	(ABC) transporter
HUB98_RS20300	COG4152	abc transporter atp-binding protein
HUB98_RS20305	COG1668	transmembrane transport
HUB98_RS20310	COG2323	membrane
HUB98_RS20335	COG2226	methyltransferase
HUB98_RS20340	COG1595	DNA-templated transcription, initiation
HUB98_RS20350	COG1683	Conserved Protein
HUB98_RS20355	COG0778	Nitroreductase
HUB98_RS20360	COG1846	Transcriptional regulator
HUB98_RS20365	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUB98_RS20370	COG0640	Transcriptional regulator
HUB98_RS20375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS20380	COG0628	permease
HUB98_RS20385	COG0640	Transcriptional regulator
HUB98_RS20390	COG2217	Heavy metal translocating P-type atpase
HUB98_RS20400	COG0789	Transcriptional regulator
HUB98_RS20405	COG2814	Major facilitator Superfamily
HUB98_RS20410	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS20420	COG1956	GAF domain-containing protein
HUB98_RS20435	COG2814	Major facilitator Superfamily
HUB98_RS20440	COG1846	Transcriptional regulator
HUB98_RS20445	COG2814	Major facilitator Superfamily
HUB98_RS20460	COG1131	(ABC) transporter
HUB98_RS20475	COG2081	HI0933 family
HUB98_RS20480	COG5002	protein histidine kinase activity
HUB98_RS20490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUB98_RS20495	COG0736	holo-[acyl-carrier-protein] synthase activity
HUB98_RS20525	COG0456	acetyltransferase
HUB98_RS20535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUB98_RS20550	COG0302	gtp cyclohydrolase
HUB98_RS20555	COG0095	Lipoate-protein ligase
HUB98_RS20565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUB98_RS20575	COG1414	Transcriptional regulator
HUB98_RS20595	COG3708	Transcriptional regulator
HUB98_RS20600	COG2378	regulation of single-species biofilm formation
HUB98_RS20630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUB98_RS20640	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUB98_RS20650	COG4294	response to UV
HUB98_RS20670	COG2972	Histidine kinase
HUB98_RS20675	COG4753	response regulator
HUB98_RS20675	COG2207	Transcriptional regulator
HUB98_RS20680	COG1653	transport
HUB98_RS20685	COG1175	transmembrane transport
HUB98_RS20690	COG0395	ABC-type sugar transport system, permease component
HUB98_RS20695	COG2755	lipolytic protein G-D-S-L family
HUB98_RS20705	COG0697	spore germination
HUB98_RS20710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS20715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUB98_RS20720	COG1316	TRANSCRIPTIONal
HUB98_RS20725	COG4555	ABC transporter
HUB98_RS20740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUB98_RS20765	COG0697	spore germination
HUB98_RS20770	COG0586	Pfam SNARE associated Golgi protein
HUB98_RS20780	COG0714	Associated with various cellular activities
HUB98_RS20790	COG1305	Transglutaminase-like
HUB98_RS20800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUB98_RS20805	COG2252	PERMEase
HUB98_RS20825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUB98_RS20830	COG0154	amidase activity
HUB98_RS20860	COG0589	response to stress
HUB98_RS20865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUB98_RS20870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUB98_RS20875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUB98_RS20885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUB98_RS20890	COG0047	phosphoribosylformylglycinamidine synthase activity
HUB98_RS20895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUB98_RS20900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUB98_RS20910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUB98_RS20915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUB98_RS20925	COG0151	Belongs to the GarS family
HUB98_RS20930	COG1253	flavin adenine dinucleotide binding
HUB98_RS20935	COG1253	flavin adenine dinucleotide binding
HUB98_RS20940	COG0346	lactoylglutathione lyase activity
HUB98_RS20945	COG0400	carboxylic ester hydrolase activity
HUB98_RS20950	COG0596	Alpha beta hydrolase
HUB98_RS20955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUB98_RS20975	COG2207	Transcriptional regulator
HUB98_RS20995	COG3384	dioxygenase
HUB98_RS21010	COG1470	cell adhesion involved in biofilm formation
HUB98_RS21015	COG1392	Phosphate transport regulator
HUB98_RS21020	COG0306	phosphate transporter
HUB98_RS21025	COG0598	Magnesium transport protein CorA
HUB98_RS21030	COG4335	DNA alkylation repair
HUB98_RS21040	COG4496	protein, YerC YecD
HUB98_RS21055	COG1597	lipid kinase activity
HUB98_RS21060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUB98_RS21065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUB98_RS21070	COG0318	PFAM AMP-dependent synthetase and ligase
HUB98_RS21095	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUB98_RS21105	COG1131	(ABC) transporter
HUB98_RS21155	COG1073	alpha beta
HUB98_RS21180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUB98_RS21185	COG2972	Histidine kinase
HUB98_RS21185	COG0745	RESPONSE REGULATOR receiver
HUB98_RS21190	COG3279	Response regulator of the LytR AlgR family
HUB98_RS21205	COG3214	Protein conserved in bacteria
HUB98_RS21210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUB98_RS21225	COG0398	Pfam SNARE associated Golgi protein
HUB98_RS21230	COG0745	RESPONSE REGULATOR receiver
HUB98_RS21235	COG5002	protein histidine kinase activity
HUB98_RS21235	COG0642	Histidine kinase
HUB98_RS21245	COG4978	Transcriptional regulator
HUB98_RS21245	COG0789	Transcriptional regulator
HUB98_RS21250	COG1132	(ABC) transporter
HUB98_RS21255	COG1132	(ABC) transporter
HUB98_RS21260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUB98_RS21260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUB98_RS21280	COG3345	alpha-galactosidase
HUB98_RS21290	COG3279	Response regulator of the LytR AlgR family
HUB98_RS21295	COG2972	Histidine kinase
HUB98_RS21295	COG0745	RESPONSE REGULATOR receiver
HUB98_RS21300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS21320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HUB98_RS21325	COG5426	von Willebrand factor, type A
HUB98_RS21335	COG2972	Histidine kinase
HUB98_RS21340	COG4753	response regulator
HUB98_RS21340	COG2207	Transcriptional regulator
HUB98_RS21350	COG4209	transmembrane transport
HUB98_RS21355	COG0395	ABC-type sugar transport system, permease component
HUB98_RS21375	COG0657	acetylesterase activity
HUB98_RS21385	COG0659	secondary active sulfate transmembrane transporter activity
HUB98_RS21395	COG1113	amino acid transport
HUB98_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS21415	COG0456	acetyltransferase
HUB98_RS21470	COG0768	penicillin binding
HUB98_RS21490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS21500	COG2814	Major facilitator Superfamily
HUB98_RS21525	COG1428	Deoxynucleoside kinase
HUB98_RS21530	COG1428	Deoxynucleoside kinase
HUB98_RS21540	COG0789	Transcriptional regulator
HUB98_RS21545	COG0352	thiamine-phosphate diphosphorylase activity
HUB98_RS21550	COG0351	phosphomethylpyrimidine kinase
HUB98_RS21580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUB98_RS21585	COG2011	ABC-type metal ion transport system permease component
HUB98_RS21595	COG2205	protein histidine kinase activity
HUB98_RS21595	COG5002	protein histidine kinase activity
HUB98_RS21595	COG0784	Response regulator, receiver
HUB98_RS21600	COG0745	RESPONSE REGULATOR receiver
HUB98_RS21610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUB98_RS21630	COG2116	formate transmembrane transporter activity
HUB98_RS21650	COG0604	alcohol dehydrogenase
HUB98_RS21665	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS21665	COG2207	Transcriptional regulator
HUB98_RS21675	COG2376	Dihydroxyacetone kinase
HUB98_RS21685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUB98_RS21710	COG0454	-acetyltransferase
HUB98_RS21715	COG1113	amino acid transport
HUB98_RS21730	COG0840	transmembrane signaling receptor activity
HUB98_RS21735	COG0583	DNA-binding transcription factor activity
HUB98_RS21740	COG1063	alcohol dehydrogenase
HUB98_RS21780	COG2140	Oxalate decarboxylase
HUB98_RS21790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS21795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS21800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS21805	COG1120	ATPase activity
HUB98_RS21810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUB98_RS21810	COG0189	ligase activity
HUB98_RS21820	COG0477	Major facilitator Superfamily
HUB98_RS21835	COG4264	IucA IucC family
HUB98_RS21850	COG0019	diaminopimelate decarboxylase activity
HUB98_RS21885	COG1061	Type III restriction enzyme res subunit
HUB98_RS21895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUB98_RS21925	COG1061	Type III restriction enzyme res subunit
HUB98_RS21945	COG1595	DNA-templated transcription, initiation
HUB98_RS22005	COG2084	Dehydrogenase
HUB98_RS22015	COG1132	(ABC) transporter
HUB98_RS22020	COG1132	(ABC) transporter
HUB98_RS22025	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS22030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUB98_RS22040	COG3639	organic phosphonate transmembrane transporter activity
HUB98_RS22080	COG0745	RESPONSE REGULATOR receiver
HUB98_RS22085	COG5002	protein histidine kinase activity
HUB98_RS22095	COG1136	(ABC) transporter
HUB98_RS22100	COG0577	efflux transmembrane transporter activity
HUB98_RS22100	COG1136	(ABC) transporter
HUB98_RS22110	COG5297	Belongs to the glycosyl hydrolase family 6
HUB98_RS22115	COG3401	FG-GAP repeat protein
HUB98_RS22130	COG2207	Transcriptional regulator
HUB98_RS22130	COG4753	response regulator
HUB98_RS22135	COG3711	transcriptional antiterminator
HUB98_RS22145	COG3394	polysaccharide catabolic process
HUB98_RS22150	COG1486	melibiose metabolic process
HUB98_RS22170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUB98_RS22175	COG0765	amino acid transport
HUB98_RS22180	COG1126	abc transporter atp-binding protein
HUB98_RS22190	COG1511	domain protein
HUB98_RS22195	COG1309	transcriptional regulator
HUB98_RS22230	COG1518	maintenance of DNA repeat elements
HUB98_RS22235	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUB98_RS22245	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS22255	COG2197	response regulator
HUB98_RS22260	COG1278	Cold shock
HUB98_RS22265	COG4753	response regulator
HUB98_RS22265	COG2207	Transcriptional regulator
HUB98_RS22270	COG2972	Histidine kinase
HUB98_RS22275	COG1879	ABC-type sugar transport system periplasmic component
HUB98_RS22290	COG4211	Belongs to the binding-protein-dependent transport system permease family
HUB98_RS22295	COG4191	Histidine kinase
HUB98_RS22300	COG2311	Membrane
HUB98_RS22330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS22335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS22340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS22345	COG2207	Transcriptional regulator
HUB98_RS22345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS22360	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUB98_RS22365	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUB98_RS22370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUB98_RS22375	COG1725	Transcriptional regulator
HUB98_RS22380	COG1131	(ABC) transporter
HUB98_RS22400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUB98_RS22410	COG4946	Tricorn protease homolog
HUB98_RS22410	COG0823	Involved in the tonB-independent uptake of proteins
HUB98_RS22410	COG1506	peptidase
HUB98_RS22420	COG1725	Transcriptional regulator
HUB98_RS22425	COG1131	(ABC) transporter
HUB98_RS22450	COG3541	Predicted nucleotidyltransferase
HUB98_RS22480	COG1609	Transcriptional regulator
HUB98_RS22500	COG0673	inositol 2-dehydrogenase activity
HUB98_RS22515	COG2112	serine threonine protein kinase
HUB98_RS22525	COG0686	Belongs to the AlaDH PNT family
HUB98_RS22545	COG3829	transcription factor binding
HUB98_RS22545	COG3290	protein histidine kinase activity
HUB98_RS22550	COG0506	proline dehydrogenase activity
HUB98_RS22555	COG1012	belongs to the aldehyde dehydrogenase family
HUB98_RS22560	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HUB98_RS22565	COG1027	Aspartate ammonia-lyase
HUB98_RS22570	COG0840	transmembrane signaling receptor activity
HUB98_RS22585	COG0346	lactoylglutathione lyase activity
HUB98_RS22590	COG5522	Integral membrane protein (intg_mem_TP0381)
HUB98_RS22600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUB98_RS22630	COG2205	protein histidine kinase activity
HUB98_RS22655	COG1316	TRANSCRIPTIONal
HUB98_RS22660	COG0840	transmembrane signaling receptor activity
HUB98_RS22670	COG5297	Belongs to the glycosyl hydrolase family 6
HUB98_RS22670	COG4447	cellulose binding
HUB98_RS22690	COG3693	PFAM glycoside hydrolase, family 10
HUB98_RS22695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUB98_RS22700	COG1522	sequence-specific DNA binding
HUB98_RS22715	COG1132	(ABC) transporter
HUB98_RS22730	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS22745	COG0395	ABC-type sugar transport system, permease component
HUB98_RS22750	COG3507	Belongs to the glycosyl hydrolase 43 family
HUB98_RS22775	COG3940	Belongs to the glycosyl hydrolase 43 family
HUB98_RS22780	COG2217	Heavy metal translocating P-type atpase
HUB98_RS22785	COG2508	Transcriptional regulator
HUB98_RS22795	COG0402	S-adenosylhomocysteine deaminase activity
HUB98_RS22805	COG2814	Major facilitator Superfamily
HUB98_RS22810	COG2223	nitrite transmembrane transporter activity
HUB98_RS22825	COG0720	synthase
HUB98_RS22830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUB98_RS22865	COG0442	prolyl-tRNA aminoacylation
HUB98_RS22870	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS22880	COG1396	sequence-specific DNA binding
HUB98_RS22890	COG4585	Histidine kinase
HUB98_RS22890	COG2203	Gaf domain
HUB98_RS22895	COG2197	response regulator
HUB98_RS22955	COG2823	Periplasmic or secreted lipoprotein
HUB98_RS22955	COG1652	LysM domain
HUB98_RS22975	COG3299	homolog of phage Mu protein gp47
HUB98_RS23030	COG4193	domain, Protein
HUB98_RS23040	COG3628	GPW Gp25 family protein
HUB98_RS23045	COG3299	homolog of phage Mu protein gp47
HUB98_RS23070	COG0747	negative chemotaxis
HUB98_RS23090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUB98_RS23095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS23100	COG0840	transmembrane signaling receptor activity
HUB98_RS23120	COG3773	Cell wall hydrolase
HUB98_RS23125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUB98_RS23130	COG1309	transcriptional regulator
HUB98_RS23135	COG1511	domain protein
HUB98_RS23140	COG0067	glutamate synthase
HUB98_RS23140	COG0069	glutamate synthase activity
HUB98_RS23140	COG0070	glutamate synthase
HUB98_RS23160	COG4464	protein tyrosine phosphatase activity
HUB98_RS23170	COG0489	protein tyrosine kinase activity
HUB98_RS23175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUB98_RS23180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUB98_RS23185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUB98_RS23210	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS23215	COG0438	transferase activity, transferring glycosyl groups
HUB98_RS23230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUB98_RS23235	COG1316	TRANSCRIPTIONal
HUB98_RS23250	COG1131	(ABC) transporter
HUB98_RS23255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HUB98_RS23260	COG0628	permease
HUB98_RS23265	COG1253	flavin adenine dinucleotide binding
HUB98_RS23270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUB98_RS23275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS23280	COG1793	dna ligase
HUB98_RS23280	COG3285	dna ligase
HUB98_RS23290	COG0531	amino acid
HUB98_RS23300	COG2514	catechol 2,3-dioxygenase activity
HUB98_RS23305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUB98_RS23320	COG0802	atpase or kinase
HUB98_RS23325	COG1214	PFAM Peptidase M22, glycoprotease
HUB98_RS23330	COG0456	acetyltransferase
HUB98_RS23335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUB98_RS23340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUB98_RS23350	COG0488	(ABC) transporter
HUB98_RS23355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUB98_RS23360	COG0315	cyclic pyranopterin monophosphate synthase activity
HUB98_RS23365	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUB98_RS23370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUB98_RS23375	COG0805	protein transport
HUB98_RS23380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUB98_RS23385	COG0459	protein refolding
HUB98_RS23395	COG2826	transposase and inactivated derivatives, IS30 family
HUB98_RS23450	COG0235	Class ii aldolase
HUB98_RS23455	COG0531	amino acid
HUB98_RS23470	COG2113	Glycine betaine
HUB98_RS23475	COG4175	Glycine betaine
HUB98_RS23475	COG0517	IMP dehydrogenase activity
HUB98_RS23480	COG1510	regulation of RNA biosynthetic process
HUB98_RS23485	COG2169	Transcriptional regulator
HUB98_RS23500	COG1131	(ABC) transporter
HUB98_RS23505	COG0326	Molecular chaperone. Has ATPase activity
HUB98_RS23520	COG1476	TRANSCRIPTIONal
HUB98_RS23525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HUB98_RS23530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUB98_RS23535	COG0864	Transcriptional regulator
HUB98_RS23540	COG2337	Toxic component of a toxin-antitoxin (TA) module
HUB98_RS23550	COG2183	response to ionizing radiation
HUB98_RS23560	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS23585	COG0561	phosphatase activity
HUB98_RS23590	COG1349	DNA-binding transcription factor activity
HUB98_RS23635	COG0830	nickel cation binding
HUB98_RS23645	COG0386	Belongs to the glutathione peroxidase family
HUB98_RS23655	COG1011	Hydrolase
HUB98_RS23665	COG1764	response to oxidative stress
HUB98_RS23680	COG3011	Protein conserved in bacteria
HUB98_RS23745	COG1090	epimerase
HUB98_RS23760	COG0788	formyltetrahydrofolate deformylase activity
HUB98_RS23780	COG0166	Belongs to the GPI family
HUB98_RS23785	COG1739	Uncharacterized protein family UPF0029
HUB98_RS23795	COG0432	Pfam Uncharacterised protein family UPF0047
HUB98_RS23805	COG4208	sulfate ABC transporter
HUB98_RS23810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HUB98_RS23815	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HUB98_RS23825	COG0321	lipoyl(octanoyl) transferase activity
HUB98_RS23825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUB98_RS23835	COG0740	serine-type endopeptidase activity
HUB98_RS23840	COG1725	Transcriptional regulator
HUB98_RS23855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS23860	COG0697	spore germination
HUB98_RS23870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUB98_RS23875	COG0561	phosphatase activity
HUB98_RS23880	COG0095	Lipoate-protein ligase
HUB98_RS23885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUB98_RS23895	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUB98_RS23905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUB98_RS23910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUB98_RS23915	COG1120	ATPase activity
HUB98_RS23920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUB98_RS23930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUB98_RS23935	COG1492	cobalamin metabolic process
HUB98_RS23950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUB98_RS23970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUB98_RS23985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUB98_RS23990	COG2205	protein histidine kinase activity
HUB98_RS23995	COG0745	RESPONSE REGULATOR receiver
HUB98_RS24000	COG4942	peptidase
HUB98_RS24005	COG1247	-acetyltransferase
HUB98_RS24020	COG0004	ammonium transporteR
HUB98_RS24055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUB98_RS24065	COG3610	response to peptide
HUB98_RS24070	COG2966	Psort location CytoplasmicMembrane, score
HUB98_RS24085	COG1595	DNA-templated transcription, initiation
HUB98_RS24110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HUB98_RS24115	COG4474	Belongs to the UPF0398 family
HUB98_RS24125	COG1132	(ABC) transporter
HUB98_RS24135	COG0514	ATP-dependent DNA helicase (RecQ)
HUB98_RS24140	COG3547	Transposase (IS116 IS110 IS902 family)
HUB98_RS24150	COG4974	Belongs to the 'phage' integrase family
HUB98_RS24305	COG0318	PFAM AMP-dependent synthetase and ligase
HUB98_RS24330	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUB98_RS24390	COG1131	(ABC) transporter
HUB98_RS24395	COG1994	Peptidase M50
HUB98_RS24400	COG0535	radical SAM domain protein
HUB98_RS24465	COG0477	Major facilitator Superfamily
HUB98_RS24470	COG0583	DNA-binding transcription factor activity
HUB98_RS24510	COG0840	transmembrane signaling receptor activity
HUB98_RS24515	COG2267	carboxylic ester hydrolase activity
HUB98_RS24520	COG2972	Histidine kinase
HUB98_RS24525	COG4209	transmembrane transport
HUB98_RS24530	COG0395	ABC-type sugar transport system, permease component
HUB98_RS24550	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUB98_RS24555	COG1733	regulation of RNA biosynthetic process
HUB98_RS24600	COG1230	cation diffusion facilitator family transporter
HUB98_RS24605	COG0745	RESPONSE REGULATOR receiver
HUB98_RS24610	COG5002	protein histidine kinase activity
HUB98_RS24610	COG3850	Histidine kinase
HUB98_RS24615	COG0577	efflux transmembrane transporter activity
HUB98_RS24620	COG1136	(ABC) transporter
HUB98_RS24660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUB98_RS24745	COG0384	phenazine biosynthesis protein PhzF
HUB98_RS24770	COG0494	nUDIX hydrolase
HUB98_RS24815	COG1011	Hydrolase
HUB98_RS24825	COG4326	sporulation control protein
HUB98_RS24840	COG2318	DinB family
HUB98_RS24855	COG0500	methyltransferase
HUB98_RS24860	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS24875	COG1690	Belongs to the RtcB family
HUB98_RS24895	COG0515	serine threonine protein kinase
HUB98_RS24895	COG2815	serine threonine protein kinase
HUB98_RS24910	COG1349	DNA-binding transcription factor activity
HUB98_RS24935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUB98_RS24945	COG1090	epimerase
HUB98_RS24950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUB98_RS24960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUB98_RS24975	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS25005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUB98_RS25015	COG2363	Small membrane protein
HUB98_RS25020	COG1072	(Pantothenic acid kinase))
HUB98_RS25030	COG1056	cytidyltransferase-related domain
HUB98_RS25030	COG1051	belongs to the nudix hydrolase family
HUB98_RS25045	COG0456	acetyltransferase
HUB98_RS25055	COG0567	Dehydrogenase, E1 component
HUB98_RS25060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUB98_RS25070	COG1482	cell wall glycoprotein biosynthetic process
HUB98_RS25075	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUB98_RS25080	COG1242	4 iron, 4 sulfur cluster binding
HUB98_RS25090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUB98_RS25100	COG4209	transmembrane transport
HUB98_RS25105	COG0395	ABC-type sugar transport system, permease component
HUB98_RS25110	COG1653	transport
HUB98_RS25115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUB98_RS25120	COG0671	phosphoesterase, PA-phosphatase related
HUB98_RS25125	COG1215	transferase activity, transferring glycosyl groups
HUB98_RS25135	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUB98_RS25140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUB98_RS25175	COG0028	Belongs to the TPP enzyme family
HUB98_RS25180	COG0440	acetolactate synthase activity
HUB98_RS25185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUB98_RS25190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUB98_RS25195	COG0667	Aldo Keto reductase
HUB98_RS25200	COG0473	3-isopropylmalate dehydrogenase activity
HUB98_RS25205	COG0450	alkyl hydroperoxide reductase
HUB98_RS25230	COG0714	Associated with various cellular activities
HUB98_RS25245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUB98_RS25265	COG0488	(ABC) transporter
HUB98_RS25270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUB98_RS25280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HUB98_RS25295	COG1193	negative regulation of DNA recombination
HUB98_RS25300	COG3766	membrane
HUB98_RS25310	COG0477	Major facilitator Superfamily
HUB98_RS25330	COG1522	sequence-specific DNA binding
HUB98_RS25335	COG0436	Aminotransferase
HUB98_RS25355	COG2096	Adenosyltransferase
HUB98_RS25360	COG0564	pseudouridine synthase activity
HUB98_RS25365	COG1393	Belongs to the ArsC family
HUB98_RS25370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUB98_RS25380	COG2258	MOSC domain
HUB98_RS25385	COG1940	carbohydrate kinase activity
HUB98_RS25395	COG0598	Magnesium transport protein CorA
HUB98_RS25400	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HUB98_RS25405	COG0626	cystathionine gamma-synthase activity
HUB98_RS25410	COG0626	cystathionine gamma-synthase activity
HUB98_RS25415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUB98_RS25420	COG0667	Aldo Keto reductase
HUB98_RS25425	COG1063	alcohol dehydrogenase
HUB98_RS25430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS25435	COG0475	glutathione-regulated potassium exporter activity
HUB98_RS25440	COG0490	domain, Protein
HUB98_RS25455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUB98_RS25460	COG3584	3D domain protein
HUB98_RS25470	COG4758	membrane
HUB98_RS25475	COG4585	Histidine kinase
HUB98_RS25480	COG2197	response regulator
HUB98_RS25485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUB98_RS25490	COG0745	RESPONSE REGULATOR receiver
HUB98_RS25495	COG5002	protein histidine kinase activity
HUB98_RS25495	COG3850	Histidine kinase
HUB98_RS25500	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUB98_RS25505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUB98_RS25510	COG0174	glutamine synthetase
HUB98_RS25520	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUB98_RS25525	COG2002	toxin-antitoxin pair type II binding
HUB98_RS25540	COG4209	transmembrane transport
HUB98_RS25545	COG0395	ABC-type sugar transport system, permease component
HUB98_RS25565	COG4632	Exopolysaccharide biosynthesis protein
HUB98_RS25565	COG5434	Belongs to the glycosyl hydrolase 28 family
HUB98_RS25580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUB98_RS25595	COG2766	serine protein kinase
HUB98_RS25600	COG0840	transmembrane signaling receptor activity
HUB98_RS25615	COG3300	MHYT domain
HUB98_RS25615	COG5001	Diguanylate cyclase
HUB98_RS25620	COG2719	SpoVR family
HUB98_RS25625	COG2718	Belongs to the UPF0229 family
HUB98_RS25630	COG2270	Major facilitator Superfamily
HUB98_RS25635	COG3551	Protein conserved in bacteria
HUB98_RS25670	COG1132	(ABC) transporter
HUB98_RS25675	COG0529	Catalyzes the synthesis of activated sulfate
HUB98_RS25700	COG2363	Small membrane protein
HUB98_RS25710	COG3377	Domain of unknown function (DUF1805)
HUB98_RS25720	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HUB98_RS25725	COG0783	Belongs to the Dps family
HUB98_RS25735	COG0396	ATPase activity
HUB98_RS25740	COG0719	Fe-S assembly protein
HUB98_RS25745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUB98_RS25750	COG0822	iron-sulfur transferase activity
HUB98_RS25755	COG0719	Fe-S assembly protein
HUB98_RS25785	COG0314	molybdopterin synthase activity
HUB98_RS25790	COG0737	Belongs to the 5'-nucleotidase family
HUB98_RS25800	COG0535	radical SAM domain protein
HUB98_RS25805	COG1253	flavin adenine dinucleotide binding
HUB98_RS25820	COG3546	catalase activity
HUB98_RS25845	COG0673	inositol 2-dehydrogenase activity
HUB98_RS25855	COG1175	transmembrane transport
HUB98_RS25860	COG0395	ABC-type sugar transport system, permease component
HUB98_RS25865	COG2972	Histidine kinase
HUB98_RS25870	COG4753	response regulator
HUB98_RS25870	COG2207	Transcriptional regulator
HUB98_RS25890	COG0189	ligase activity
HUB98_RS25900	COG0189	ligase activity
HUB98_RS25905	COG0189	ligase activity
HUB98_RS25910	COG0189	ligase activity
HUB98_RS25925	COG4109	DRTGG domain
HUB98_RS25950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUB98_RS25960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUB98_RS25965	COG0825	malonyl-CoA metabolic process
HUB98_RS25970	COG0469	pyruvate kinase activity
HUB98_RS25975	COG0824	Thioesterase
HUB98_RS25980	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUB98_RS25985	COG0628	permease
HUB98_RS25990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUB98_RS26035	COG3331	DNA recombination
HUB98_RS26095	COG0582	viral genome integration into host DNA
HUB98_RS26115	COG4626	Terminase
HUB98_RS26115	COG1802	Transcriptional regulator
HUB98_RS26240	COG4824	toxin secretion phage lysis holin
HUB98_RS26245	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUB98_RS26280	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUB98_RS26325	COG3331	DNA recombination
HUB98_RS26385	COG0582	viral genome integration into host DNA
HUB98_RS26570	COG4824	toxin secretion phage lysis holin
HUB98_RS26575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUB98_RS26610	COG0372	Belongs to the citrate synthase family
HUB98_RS26615	COG0538	isocitrate dehydrogenase activity
HUB98_RS26620	COG0039	L-malate dehydrogenase activity
HUB98_RS26640	COG5002	protein histidine kinase activity
HUB98_RS26645	COG0745	RESPONSE REGULATOR receiver
HUB98_RS26655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUB98_RS26660	COG0704	Plays a role in the regulation of phosphate uptake
HUB98_RS26670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUB98_RS26675	COG1971	Probably functions as a manganese efflux pump
HUB98_RS26680	COG0237	dephospho-CoA kinase activity
HUB98_RS26685	COG0741	lytic transglycosylase activity
HUB98_RS26695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUB98_RS26710	COG0693	protein deglycase activity
HUB98_RS26725	COG0583	DNA-binding transcription factor activity
HUB98_RS26740	COG0697	spore germination
HUB98_RS26750	COG0531	amino acid
HUB98_RS26755	COG0596	Alpha beta hydrolase
HUB98_RS26765	COG0277	FAD linked oxidase domain protein
HUB98_RS26775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HUB98_RS26780	COG0778	Nitroreductase
HUB98_RS26785	COG1846	Transcriptional regulator
HUB98_RS26795	COG2072	flavoprotein involved in K transport
HUB98_RS26815	COG1349	DNA-binding transcription factor activity
HUB98_RS26820	COG1105	Belongs to the carbohydrate kinase PfkB family
HUB98_RS26825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUB98_RS26825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUB98_RS26825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUB98_RS26830	COG2140	Oxalate decarboxylase
HUB98_RS26835	COG0300	oxidoreductase activity
HUB98_RS26855	COG3706	GGDEF domain
HUB98_RS26880	COG4824	toxin secretion phage lysis holin
HUB98_RS26890	COG2445	Protein of unknown function DUF86
HUB98_RS26900	COG4980	gas vesicle protein
HUB98_RS26925	COG0656	L-ascorbic acid biosynthetic process
HUB98_RS26930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUB98_RS26940	COG1368	sulfuric ester hydrolase activity
HUB98_RS26945	COG0116	Belongs to the methyltransferase superfamily
HUB98_RS26950	COG4122	O-methyltransferase activity
HUB98_RS26955	COG0252	asparaginase activity
HUB98_RS26965	COG2814	Major facilitator Superfamily
HUB98_RS26970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUB98_RS26985	COG2843	Capsule synthesis protein
HUB98_RS26990	COG0584	glycerophosphoryl diester phosphodiesterase
HUB98_RS26995	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUB98_RS27010	COG1309	transcriptional regulator
HUB98_RS27015	COG0488	(ABC) transporter
HUB98_RS27020	COG1363	Peptidase, m42
HUB98_RS27030	COG1164	Oligoendopeptidase f
HUB98_RS27045	COG1278	Cold shock
HUB98_RS27070	COG0534	Mate efflux family protein
HUB98_RS27080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUB98_RS27085	COG0513	Belongs to the DEAD box helicase family
HUB98_RS27090	COG5578	integral membrane protein
HUB98_RS27105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HUB98_RS27110	COG0705	Rhomboid family
HUB98_RS27115	COG0583	DNA-binding transcription factor activity
HUB98_RS27120	COG2738	Putative neutral zinc metallopeptidase
HUB98_RS27130	COG0004	ammonium transporteR
HUB98_RS27140	COG2176	DNA-directed DNA polymerase activity
HUB98_RS27150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS27155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUB98_RS27160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUB98_RS27165	COG1141	Ferredoxin
HUB98_RS27180	COG0167	dihydroorotate dehydrogenase activity
HUB98_RS27185	COG2357	RelA SpoT domain protein
HUB98_RS27195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS27200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HUB98_RS27200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUB98_RS27205	COG1187	pseudouridine synthase activity
HUB98_RS27210	COG0561	phosphatase activity
HUB98_RS27220	COG0454	-acetyltransferase
HUB98_RS27230	COG3949	Membrane
HUB98_RS27235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUB98_RS27250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUB98_RS27255	COG1388	LysM domain
HUB98_RS27255	COG0791	NLP P60 protein
HUB98_RS27270	COG5520	Belongs to the glycosyl hydrolase 30 family
HUB98_RS27290	COG1609	Transcriptional regulator
HUB98_RS27305	COG0366	Alpha amylase catalytic
HUB98_RS27310	COG2861	carbohydrate metabolic process
HUB98_RS27335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUB98_RS27345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUB98_RS27350	COG2755	lipolytic protein G-D-S-L family
HUB98_RS27350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUB98_RS27360	COG1175	transmembrane transport
HUB98_RS27365	COG0395	ABC-type sugar transport system, permease component
HUB98_RS27370	COG2972	Histidine kinase
HUB98_RS27380	COG3250	beta-galactosidase activity
HUB98_RS27390	COG1846	Transcriptional regulator
HUB98_RS27400	COG0025	NhaP-type Na H and K H
HUB98_RS27410	COG4895	conserved protein (DUF2196)
HUB98_RS27415	COG3069	C4-dicarboxylate transmembrane transporter activity
HUB98_RS27420	COG2972	Histidine kinase
HUB98_RS27420	COG0745	RESPONSE REGULATOR receiver
HUB98_RS27425	COG2207	Transcriptional regulator
HUB98_RS27430	COG4209	transmembrane transport
HUB98_RS27435	COG0395	ABC-type sugar transport system, permease component
HUB98_RS27455	COG3275	phosphorelay sensor kinase activity
HUB98_RS27460	COG4753	response regulator
HUB98_RS27460	COG2207	Transcriptional regulator
HUB98_RS27465	COG1653	transport
HUB98_RS27470	COG4209	transmembrane transport
HUB98_RS27475	COG0395	ABC-type sugar transport system, permease component
HUB98_RS27485	COG1874	Beta-galactosidase
HUB98_RS27495	COG1418	mRNA catabolic process
HUB98_RS27505	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS27510	COG4129	membrane
HUB98_RS27520	COG3973	AAA domain
HUB98_RS27525	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUB98_RS27535	COG2207	Transcriptional regulator
HUB98_RS27535	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS27540	COG1501	Belongs to the glycosyl hydrolase 31 family
HUB98_RS27545	COG2814	Major facilitator Superfamily
HUB98_RS27555	COG1846	Transcriptional regulator
HUB98_RS27560	COG4154	Belongs to the RbsD FucU family
HUB98_RS27565	COG0456	acetyltransferase
HUB98_RS27585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUB98_RS27590	COG1846	Transcriptional regulator
HUB98_RS27595	COG5012	cobalamin binding
HUB98_RS27600	COG0784	Response regulator, receiver
HUB98_RS27600	COG2198	Histidine kinase
HUB98_RS27600	COG2205	protein histidine kinase activity
HUB98_RS27615	COG1846	Transcriptional regulator
HUB98_RS27620	COG2409	Drug exporters of the RND superfamily
HUB98_RS27620	COG1033	growth of symbiont in host cell
HUB98_RS27625	COG2755	lipolytic protein G-D-S-L family
HUB98_RS27645	COG0246	Mannitol dehydrogenase
HUB98_RS27650	COG2721	sulfolactate sulfo-lyase activity
HUB98_RS27675	COG3386	PFAM SMP-30 Gluconolaconase
HUB98_RS27690	COG2972	Histidine kinase
HUB98_RS27710	COG3250	beta-galactosidase activity
HUB98_RS27730	COG2207	Transcriptional regulator
HUB98_RS27730	COG3708	Transcriptional regulator
HUB98_RS27735	COG0742	ribosomal rna small subunit methyltransferase
HUB98_RS27740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUB98_RS27745	COG3314	Sporulation integral membrane protein YlbJ
HUB98_RS27750	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUB98_RS27755	COG1323	Belongs to the UPF0348 family
HUB98_RS27765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUB98_RS27770	COG2050	protein possibly involved in aromatic compounds catabolism
HUB98_RS27770	COG1349	DNA-binding transcription factor activity
HUB98_RS27775	COG0416	fatty acid biosynthetic process
HUB98_RS27785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUB98_RS27790	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS27795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUB98_RS27800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUB98_RS27805	COG0571	ribonuclease III activity
HUB98_RS27810	COG1196	nuclear chromosome segregation
HUB98_RS27815	COG0552	protein localization to endoplasmic reticulum
HUB98_RS27820	COG1272	protein, Hemolysin III
HUB98_RS27825	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HUB98_RS27830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUB98_RS27835	COG0228	four-way junction DNA binding
HUB98_RS27845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUB98_RS27850	COG0336	Belongs to the RNA methyltransferase TrmD family
HUB98_RS27855	COG0726	polysaccharide deacetylase
HUB98_RS27860	COG0335	large ribosomal subunit rRNA binding
HUB98_RS27875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUB98_RS27885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUB98_RS27890	COG0792	nuclease activity
HUB98_RS27895	COG0778	Nitroreductase
HUB98_RS27900	COG0606	chelatase, subunit chli
HUB98_RS27905	COG1846	Transcriptional regulator
HUB98_RS27910	COG0045	succinate-CoA ligase (ADP-forming) activity
HUB98_RS27915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HUB98_RS27920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUB98_RS27920	COG0758	DNA mediated transformation
HUB98_RS27925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUB98_RS27930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HUB98_RS27935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUB98_RS27940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUB98_RS27945	COG1815	bacterial-type flagellum-dependent cell motility
HUB98_RS27950	COG1558	bacterial-type flagellum-dependent cell motility
HUB98_RS27960	COG1766	The M ring may be actively involved in energy transduction
HUB98_RS27965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUB98_RS27975	COG1157	protein secretion by the type III secretion system
HUB98_RS27980	COG2882	bacterial-type flagellum organization
HUB98_RS27995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HUB98_RS28005	COG4786	Flagellar basal body rod
HUB98_RS28020	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUB98_RS28025	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUB98_RS28025	COG1776	CheC inhibitor of MCP methylation
HUB98_RS28030	COG2201	protein-glutamate methylesterase activity
HUB98_RS28040	COG1338	Plays a role in the flagellum-specific transport system
HUB98_RS28045	COG1987	bacterial-type flagellum assembly
HUB98_RS28050	COG1684	flagellar biosynthetic protein fliR
HUB98_RS28055	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUB98_RS28060	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUB98_RS28065	COG1419	protein localization to endoplasmic reticulum
HUB98_RS28070	COG0455	bacterial-type flagellum organization
HUB98_RS28075	COG2201	protein-glutamate methylesterase activity
HUB98_RS28080	COG2198	Histidine kinase
HUB98_RS28080	COG0643	Histidine kinase
HUB98_RS28085	COG0835	chemotaxis
HUB98_RS28090	COG1776	CheC inhibitor of MCP methylation
HUB98_RS28095	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HUB98_RS28105	COG1191	sigma factor activity
HUB98_RS28130	COG0052	Belongs to the universal ribosomal protein uS2 family
HUB98_RS28135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUB98_RS28140	COG0528	UMP kinase activity
HUB98_RS28145	COG0233	cytoplasmic translational termination
HUB98_RS28150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUB98_RS28155	COG4589	Belongs to the CDS family
HUB98_RS28160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUB98_RS28165	COG0750	zinc metalloprotease
HUB98_RS28170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUB98_RS28175	COG2176	DNA-directed DNA polymerase activity
HUB98_RS28180	COG0779	Required for maturation of 30S ribosomal subunits
HUB98_RS28185	COG0195	Participates in both transcription termination and antitermination
HUB98_RS28195	COG1358	cellular component organization or biogenesis
HUB98_RS28205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUB98_RS28210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUB98_RS28215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUB98_RS28220	COG0196	riboflavin kinase activity
HUB98_RS28225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUB98_RS28230	COG1185	polyribonucleotide nucleotidyltransferase activity
HUB98_RS28235	COG0726	polysaccharide deacetylase
HUB98_RS28240	COG0612	Peptidase, M16
HUB98_RS28245	COG0756	dUTP diphosphatase activity
HUB98_RS28250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUB98_RS28255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUB98_RS28260	COG0527	aspartate kinase activity
HUB98_RS28265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUB98_RS28270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUB98_RS28275	COG0740	serine-type endopeptidase activity
HUB98_RS28295	COG0612	Peptidase, M16
HUB98_RS28300	COG0612	Peptidase, M16
HUB98_RS28305	COG0300	oxidoreductase activity
HUB98_RS28320	COG1426	Protein conserved in bacteria
HUB98_RS28335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUB98_RS28340	COG1058	Belongs to the CinA family
HUB98_RS28340	COG1546	Belongs to the CinA family
HUB98_RS28350	COG2137	regulation of response to DNA damage stimulus
HUB98_RS28355	COG1418	mRNA catabolic process
HUB98_RS28360	COG1692	metallophosphoesterase
HUB98_RS28365	COG2359	stage V sporulation protein S
HUB98_RS28375	COG4869	propanediol catabolic process
HUB98_RS28380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUB98_RS28385	COG4550	Control of competence regulator ComK, YlbF/YmcA
HUB98_RS28400	COG1335	isochorismatase
HUB98_RS28405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUB98_RS28415	COG0604	alcohol dehydrogenase
HUB98_RS28425	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUB98_RS28430	COG0523	cobalamin synthesis protein
HUB98_RS28440	COG0018	arginyl-trna synthetase
HUB98_RS28450	COG1132	(ABC) transporter
HUB98_RS28455	COG1132	(ABC) transporter
HUB98_RS28460	COG4841	protein insertion into membrane
HUB98_RS28475	COG2707	UPF0756 membrane protein
HUB98_RS28480	COG0492	ferredoxin-NADP+ reductase activity
HUB98_RS28485	COG0640	Transcriptional regulator
HUB98_RS28495	COG1376	ErfK ybiS ycfS ynhG family protein
HUB98_RS28500	COG1247	-acetyltransferase
HUB98_RS28520	COG1674	ftsk spoiiie
HUB98_RS28555	COG1028	Short-chain dehydrogenase reductase Sdr
HUB98_RS28560	COG1643	Atp-dependent helicase
HUB98_RS28600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUB98_RS28605	COG3599	regulation of cell shape
HUB98_RS28610	COG1959	2 iron, 2 sulfur cluster binding
HUB98_RS28750	COG0395	ABC-type sugar transport system, permease component
HUB98_RS28770	COG1175	transmembrane transport
HUB98_RS28775	COG0395	ABC-type sugar transport system, permease component
HUB98_RS28805	COG2207	Transcriptional regulator
HUB98_RS28805	COG4753	response regulator
HUB98_RS28810	COG2972	Histidine kinase
HUB98_RS28815	COG1879	ABC-type sugar transport system periplasmic component
HUB98_RS28825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUB98_RS28830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUB98_RS28835	COG1879	ABC-type sugar transport system periplasmic component
HUB98_RS28870	COG0596	Alpha beta hydrolase
HUB98_RS28890	COG0386	Belongs to the glutathione peroxidase family
HUB98_RS28905	COG1361	Conserved repeat domain
HUB98_RS28910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUB98_RS28925	COG0109	protoheme IX farnesyltransferase activity
HUB98_RS28935	COG0583	DNA-binding transcription factor activity
HUB98_RS28945	COG1609	Transcriptional regulator
HUB98_RS28960	COG0745	RESPONSE REGULATOR receiver
HUB98_RS28965	COG5002	protein histidine kinase activity
HUB98_RS28970	COG0785	Cytochrome C biogenesis protein
HUB98_RS28975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUB98_RS28980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUB98_RS28980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUB98_RS29000	COG1902	pentaerythritol trinitrate reductase activity
HUB98_RS29005	COG1349	DNA-binding transcription factor activity
HUB98_RS29010	COG1764	response to oxidative stress
HUB98_RS29025	COG2706	6-phosphogluconolactonase activity
HUB98_RS29030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HUB98_RS29035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUB98_RS29040	COG1733	regulation of RNA biosynthetic process
HUB98_RS29045	COG1164	Oligoendopeptidase f
HUB98_RS29055	COG1070	Carbohydrate kinase
HUB98_RS29060	COG1349	DNA-binding transcription factor activity
HUB98_RS29065	COG0247	lactate metabolic process
HUB98_RS29070	COG1139	Iron-sulfur cluster binding protein
HUB98_RS29075	COG1556	Lactate utilization protein
HUB98_RS29090	COG0673	inositol 2-dehydrogenase activity
HUB98_RS29100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUB98_RS29110	COG2176	DNA-directed DNA polymerase activity
HUB98_RS29120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUB98_RS29125	COG2207	Transcriptional regulator
HUB98_RS29125	COG1917	Cupin 2, conserved barrel domain protein
HUB98_RS29130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUB98_RS29130	COG0574	Belongs to the PEP-utilizing enzyme family
HUB98_RS29135	COG1368	sulfuric ester hydrolase activity
HUB98_RS29140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUB98_RS29155	COG1227	inorganic diphosphatase activity
HUB98_RS29160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUB98_RS29175	COG2198	Histidine kinase
HUB98_RS29175	COG0784	Response regulator, receiver
HUB98_RS29175	COG2205	protein histidine kinase activity
HUB98_RS29195	COG1454	alcohol dehydrogenase