locus-tag	class	description
B1222_RS00145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1222_RS00145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1222_RS00155	COG2176	DNA-directed DNA polymerase activity
B1222_RS00165	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1222_RS00175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1222_RS00180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1222_RS00185	COG0756	dUTP diphosphatase activity
B1222_RS00385	COG4824	toxin secretion phage lysis holin
B1222_RS00390	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS00455	COG1518	maintenance of DNA repeat elements
B1222_RS00460	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B1222_RS00505	COG3328	transposase activity
B1222_RS00515	COG2801	Transposase and inactivated derivatives
B1222_RS00520	COG2801	Transposase and inactivated derivatives
B1222_RS00525	COG2801	Transposase and inactivated derivatives
B1222_RS00560	COG0789	Transcriptional regulator
B1222_RS00595	COG2427	Protein of unknown function (DUF1641)
B1222_RS00605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1222_RS00610	COG4605	iron ion homeostasis
B1222_RS00615	COG4604	ABC transporter, ATP-binding protein
B1222_RS00620	COG4607	ABC-type enterochelin transport system periplasmic component
B1222_RS00630	COG2706	6-phosphogluconolactonase activity
B1222_RS00640	COG2151	metal-sulfur cluster biosynthetic enzyme
B1222_RS00645	COG5553	Cysteine dioxygenase type I
B1222_RS00655	COG2357	RelA SpoT domain protein
B1222_RS00665	COG0501	Belongs to the peptidase M48B family
B1222_RS00675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1222_RS00680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1222_RS00690	COG1522	sequence-specific DNA binding
B1222_RS00710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1222_RS00770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1222_RS00785	COG2972	Histidine kinase
B1222_RS00795	COG2207	Transcriptional regulator
B1222_RS00800	COG0772	Belongs to the SEDS family
B1222_RS00820	COG2188	Transcriptional regulator
B1222_RS00825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS00825	COG1263	PTS System
B1222_RS00830	COG0366	Alpha amylase catalytic
B1222_RS00845	COG2801	Transposase and inactivated derivatives
B1222_RS00850	COG3227	Zinc metalloprotease (Elastase)
B1222_RS00920	COG0583	DNA-binding transcription factor activity
B1222_RS00985	COG0583	DNA-binding transcription factor activity
B1222_RS01030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1222_RS01030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1222_RS01030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1222_RS01030	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS01030	COG3321	synthase
B1222_RS01090	COG3321	synthase
B1222_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS01090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1222_RS01090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1222_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1222_RS01100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1222_RS01115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1222_RS01125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1222_RS01145	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1222_RS01150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1222_RS01175	COG1960	acyl-CoA dehydrogenase activity
B1222_RS01190	COG1475	DNA binding
B1222_RS01220	COG0583	DNA-binding transcription factor activity
B1222_RS01245	COG2801	Transposase and inactivated derivatives
B1222_RS01255	COG0189	ligase activity
B1222_RS01270	COG5386	Cell surface protein
B1222_RS01275	COG5386	Cell surface protein
B1222_RS01295	COG4509	Sortase family
B1222_RS01300	COG2329	Antibiotic biosynthesis monooxygenase
B1222_RS01310	COG0372	Belongs to the citrate synthase family
B1222_RS01315	COG2079	MmgE PrpD family protein
B1222_RS01320	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1222_RS01325	COG0583	DNA-binding transcription factor activity
B1222_RS01330	COG0583	DNA-binding transcription factor activity
B1222_RS01365	COG2801	Transposase and inactivated derivatives
B1222_RS01370	COG0574	Belongs to the PEP-utilizing enzyme family
B1222_RS01370	COG3848	Pyruvate phosphate dikinase
B1222_RS01385	COG1131	(ABC) transporter
B1222_RS01420	COG2188	Transcriptional regulator
B1222_RS01425	COG2723	6-phospho-beta-galactosidase activity
B1222_RS01435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS01435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS01435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS01445	COG1349	DNA-binding transcription factor activity
B1222_RS01485	COG1063	alcohol dehydrogenase
B1222_RS01490	COG1063	alcohol dehydrogenase
B1222_RS01500	COG2076	Multidrug Resistance protein
B1222_RS01505	COG2076	Multidrug Resistance protein
B1222_RS01510	COG1309	transcriptional regulator
B1222_RS01515	COG1309	transcriptional regulator
B1222_RS01520	COG2814	Major facilitator Superfamily
B1222_RS01545	COG2239	Acts as a magnesium transporter
B1222_RS01570	COG3739	integral membrane protein
B1222_RS01580	COG0657	acetylesterase activity
B1222_RS01590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1222_RS01620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B1222_RS01625	COG2814	Major facilitator Superfamily
B1222_RS01665	COG2732	(Barnase) inhibitor
B1222_RS01675	COG1132	(ABC) transporter
B1222_RS01695	COG1442	glycosyl transferase family 8
B1222_RS01725	COG2801	Transposase and inactivated derivatives
B1222_RS01735	COG3328	transposase activity
B1222_RS01740	COG0697	spore germination
B1222_RS01765	COG1263	PTS System
B1222_RS01765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS01765	COG2190	(PTS) system
B1222_RS01780	COG1408	metallophosphoesterase
B1222_RS01790	COG1070	Carbohydrate kinase
B1222_RS01835	COG2801	Transposase and inactivated derivatives
B1222_RS01870	COG1316	TRANSCRIPTIONal
B1222_RS01875	COG3655	Transcriptional regulator
B1222_RS01910	COG2801	Transposase and inactivated derivatives
B1222_RS01935	COG3328	transposase activity
B1222_RS01945	COG3328	transposase activity
B1222_RS01965	COG3409	Peptidoglycan-binding domain 1 protein
B1222_RS01965	COG1388	LysM domain
B1222_RS01965	COG5632	N-Acetylmuramoyl-L-alanine amidase
B1222_RS02005	COG0577	efflux transmembrane transporter activity
B1222_RS02045	COG3773	Cell wall hydrolase
B1222_RS02050	COG2259	Doxx family
B1222_RS02060	COG0577	efflux transmembrane transporter activity
B1222_RS02080	COG0534	Mate efflux family protein
B1222_RS02100	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B1222_RS02120	COG1136	(ABC) transporter
B1222_RS02130	COG1136	(ABC) transporter
B1222_RS02130	COG0577	efflux transmembrane transporter activity
B1222_RS02140	COG2239	Acts as a magnesium transporter
B1222_RS02155	COG2814	Major facilitator Superfamily
B1222_RS02160	COG2814	Major facilitator Superfamily
B1222_RS02170	COG2801	Transposase and inactivated derivatives
B1222_RS02180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1222_RS02185	COG4974	Belongs to the 'phage' integrase family
B1222_RS02195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1222_RS02215	COG2211	Major facilitator Superfamily
B1222_RS02230	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1222_RS02235	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B1222_RS02240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1222_RS02250	COG4565	transcriptional regulatory protein
B1222_RS02260	COG3290	protein histidine kinase activity
B1222_RS02270	COG1301	dicarboxylic acid transport
B1222_RS02285	COG3328	transposase activity
B1222_RS02350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1222_RS02415	COG0733	neurotransmitter:sodium symporter activity
B1222_RS02430	COG4555	ABC transporter
B1222_RS02445	COG0456	acetyltransferase
B1222_RS02465	COG1063	alcohol dehydrogenase
B1222_RS02475	COG1605	Chorismate mutase
B1222_RS02475	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B1222_RS02480	COG2002	toxin-antitoxin pair type II binding
B1222_RS02500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1222_RS02505	COG0438	transferase activity, transferring glycosyl groups
B1222_RS02555	COG0673	inositol 2-dehydrogenase activity
B1222_RS02565	COG0489	protein tyrosine kinase activity
B1222_RS02575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1222_RS02585	COG4608	Belongs to the ABC transporter superfamily
B1222_RS02615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1222_RS02630	COG2188	Transcriptional regulator
B1222_RS02645	COG3525	Glycosyl hydrolase, family 20, catalytic domain
B1222_RS02645	COG3291	Pkd domain containing protein
B1222_RS02650	COG3263	regulation of cellular component size
B1222_RS02660	COG0114	fumarate hydratase activity
B1222_RS02675	COG2801	Transposase and inactivated derivatives
B1222_RS02685	COG0517	IMP dehydrogenase activity
B1222_RS02685	COG4175	Glycine betaine
B1222_RS02700	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS02725	COG0006	proline dipeptidase activity
B1222_RS02745	COG2801	Transposase and inactivated derivatives
B1222_RS02775	COG3328	transposase activity
B1222_RS02800	COG0401	homolog of Blt101
B1222_RS02815	COG1316	TRANSCRIPTIONal
B1222_RS02820	COG4550	Control of competence regulator ComK, YlbF/YmcA
B1222_RS02830	COG4869	propanediol catabolic process
B1222_RS02850	COG2359	stage V sporulation protein S
B1222_RS02855	COG1692	metallophosphoesterase
B1222_RS02860	COG1418	mRNA catabolic process
B1222_RS02865	COG2137	regulation of response to DNA damage stimulus
B1222_RS02880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1222_RS02895	COG1426	Protein conserved in bacteria
B1222_RS02920	COG0612	Peptidase, M16
B1222_RS02945	COG0740	serine-type endopeptidase activity
B1222_RS02950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1222_RS02955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1222_RS02960	COG0527	aspartate kinase activity
B1222_RS02970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1222_RS02980	COG0756	dUTP diphosphatase activity
B1222_RS03000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1222_RS03010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1222_RS03015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B1222_RS03020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1222_RS03035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B1222_RS03040	COG0195	Participates in both transcription termination and antitermination
B1222_RS03045	COG0779	Required for maturation of 30S ribosomal subunits
B1222_RS03070	COG4589	Belongs to the CDS family
B1222_RS03085	COG0528	UMP kinase activity
B1222_RS03090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1222_RS03095	COG0052	Belongs to the universal ribosomal protein uS2 family
B1222_RS03135	COG1776	CheC inhibitor of MCP methylation
B1222_RS03145	COG0643	Histidine kinase
B1222_RS03145	COG2198	Histidine kinase
B1222_RS03150	COG2201	protein-glutamate methylesterase activity
B1222_RS03155	COG0455	bacterial-type flagellum organization
B1222_RS03165	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1222_RS03180	COG1987	bacterial-type flagellum assembly
B1222_RS03190	COG3190	flagellar
B1222_RS03200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1222_RS03200	COG1776	CheC inhibitor of MCP methylation
B1222_RS03220	COG4786	Flagellar basal body rod
B1222_RS03230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B1222_RS03240	COG2801	Transposase and inactivated derivatives
B1222_RS03290	COG1558	bacterial-type flagellum-dependent cell motility
B1222_RS03295	COG1815	bacterial-type flagellum-dependent cell motility
B1222_RS03300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B1222_RS03310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B1222_RS03315	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B1222_RS03320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1222_RS03325	COG0758	DNA mediated transformation
B1222_RS03330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B1222_RS03335	COG0045	succinate-CoA ligase (ADP-forming) activity
B1222_RS03350	COG0606	chelatase, subunit chli
B1222_RS03355	COG0792	nuclease activity
B1222_RS03385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B1222_RS03390	COG0681	Belongs to the peptidase S26 family
B1222_RS03395	COG0335	large ribosomal subunit rRNA binding
B1222_RS03415	COG0228	four-way junction DNA binding
B1222_RS03420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1222_RS03430	COG0552	protein localization to endoplasmic reticulum
B1222_RS03435	COG1196	nuclear chromosome segregation
B1222_RS03440	COG0571	ribonuclease III activity
B1222_RS03445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1222_RS03450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1222_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS03460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1222_RS03470	COG0416	fatty acid biosynthetic process
B1222_RS03475	COG1349	DNA-binding transcription factor activity
B1222_RS03480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1222_RS03490	COG3480	Lon protease (S16) C-terminal proteolytic domain
B1222_RS03495	COG3314	Sporulation integral membrane protein YlbJ
B1222_RS03500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1222_RS03505	COG0742	ribosomal rna small subunit methyltransferase
B1222_RS03525	COG2801	Transposase and inactivated derivatives
B1222_RS03545	COG3397	chitin binding
B1222_RS03580	COG2801	Transposase and inactivated derivatives
B1222_RS03630	COG0582	viral genome integration into host DNA
B1222_RS03645	COG0778	Nitroreductase
B1222_RS03650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1222_RS03655	COG5002	protein histidine kinase activity
B1222_RS03660	COG0488	(ABC) transporter
B1222_RS03675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1222_RS03685	COG0798	PFAM Bile acid sodium symporter
B1222_RS03690	COG0640	Transcriptional regulator
B1222_RS03700	COG0640	Transcriptional regulator
B1222_RS03710	COG5002	protein histidine kinase activity
B1222_RS03715	COG0577	efflux transmembrane transporter activity
B1222_RS03720	COG1136	(ABC) transporter
B1222_RS03745	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B1222_RS03750	COG2801	Transposase and inactivated derivatives
B1222_RS03760	COG2910	NAD(P)H-binding
B1222_RS03765	COG1253	flavin adenine dinucleotide binding
B1222_RS03785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1222_RS03800	COG1302	Protein conserved in bacteria
B1222_RS03805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1222_RS03815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1222_RS03830	COG0631	protein serine/threonine phosphatase activity
B1222_RS03850	COG0242	peptide deformylase activity
B1222_RS03855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1222_RS03860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1222_RS03865	COG1758	RNA polymerase activity
B1222_RS03870	COG0194	GDP metabolic process
B1222_RS03875	COG2052	Domain of unknown function (DUF370)
B1222_RS03880	COG1561	YicC-like family, N-terminal region
B1222_RS03885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B1222_RS03885	COG0646	methionine synthase
B1222_RS03890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B1222_RS03890	COG0646	methionine synthase
B1222_RS03895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1222_RS03900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1222_RS03905	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B1222_RS03910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B1222_RS03915	COG0613	PHP domain protein
B1222_RS03930	COG4471	UPF0298 protein
B1222_RS03945	COG2801	Transposase and inactivated derivatives
B1222_RS03990	COG4838	Belongs to the UPF0358 family
B1222_RS04000	COG0398	Pfam SNARE associated Golgi protein
B1222_RS04005	COG2199	diguanylate cyclase activity
B1222_RS04005	COG2203	Gaf domain
B1222_RS04010	COG2203	Gaf domain
B1222_RS04010	COG2199	diguanylate cyclase activity
B1222_RS04025	COG2801	Transposase and inactivated derivatives
B1222_RS04030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1222_RS04045	COG0454	-acetyltransferase
B1222_RS04055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1222_RS04060	COG1609	Transcriptional regulator
B1222_RS04075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1222_RS04095	COG1832	CoA-binding protein
B1222_RS04100	COG4990	cell redox homeostasis
B1222_RS04115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1222_RS04130	COG1131	(ABC) transporter
B1222_RS04145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B1222_RS04210	COG1012	belongs to the aldehyde dehydrogenase family
B1222_RS04225	COG0842	Transport permease protein
B1222_RS04250	COG4821	SIS domain
B1222_RS04260	COG4821	SIS domain
B1222_RS04265	COG4821	SIS domain
B1222_RS04270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS04270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS04280	COG3715	PTS system
B1222_RS04300	COG4493	Belongs to the UPF0637 family
B1222_RS04335	COG4846	Membrane protein involved in cytochrome C biogenesis
B1222_RS04340	COG1234	tRNA 3'-trailer cleavage
B1222_RS04355	COG4191	Histidine kinase
B1222_RS04365	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B1222_RS04410	COG3328	transposase activity
B1222_RS04440	COG1649	PFAM Uncharacterised BCR, COG1649
B1222_RS04445	COG2801	Transposase and inactivated derivatives
B1222_RS04510	COG1396	sequence-specific DNA binding
B1222_RS04555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B1222_RS04560	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B1222_RS04580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1222_RS04590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1222_RS04600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1222_RS04605	COG0540	Belongs to the ATCase OTCase family
B1222_RS04610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1222_RS04615	COG0436	Aminotransferase
B1222_RS04620	COG0564	pseudouridine synthase activity
B1222_RS04625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1222_RS04630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1222_RS04645	COG3599	regulation of cell shape
B1222_RS04655	COG0762	integral membrane protein
B1222_RS04660	COG1799	cell septum assembly
B1222_RS04665	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1222_RS04670	COG1496	oxidoreductase activity
B1222_RS04675	COG1873	PFAM PRC-barrel domain
B1222_RS04680	COG1191	sigma factor activity
B1222_RS04685	COG1191	sigma factor activity
B1222_RS04695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1222_RS04700	COG0849	cell division
B1222_RS04725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1222_RS04730	COG0772	Belongs to the SEDS family
B1222_RS04740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1222_RS04745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1222_RS04755	COG0768	penicillin binding
B1222_RS04760	COG0768	penicillin binding
B1222_RS04765	COG0768	penicillin binding
B1222_RS04775	COG0275	rRNA processing
B1222_RS04780	COG2001	Belongs to the MraZ family
B1222_RS04790	COG2801	Transposase and inactivated derivatives
B1222_RS04795	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1222_RS04810	COG0444	Belongs to the ABC transporter superfamily
B1222_RS04815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1222_RS04820	COG0601	transmembrane transport
B1222_RS04825	COG4166	transmembrane transport
B1222_RS04835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1222_RS04865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1222_RS04875	COG2801	Transposase and inactivated derivatives
B1222_RS04900	COG1217	gtp-binding protein TYPA
B1222_RS04910	COG0861	Integral membrane protein TerC family
B1222_RS04915	COG0301	tRNA thio-modification
B1222_RS04920	COG1104	cysteine desulfurase activity
B1222_RS04925	COG0741	lytic transglycosylase activity
B1222_RS04935	COG1131	(ABC) transporter
B1222_RS04965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1222_RS04970	COG2384	SAM-dependent methyltransferase
B1222_RS04985	COG0358	DNA primase activity
B1222_RS04990	COG1671	Belongs to the UPF0178 family
B1222_RS05000	COG1381	Involved in DNA repair and RecF pathway recombination
B1222_RS05005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1222_RS05015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B1222_RS05020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1222_RS05025	COG1480	7TM receptor with intracellular HD hydrolase
B1222_RS05035	COG0561	phosphatase activity
B1222_RS05045	COG1610	YqeY-like protein
B1222_RS05050	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1222_RS05055	COG0537	adenosine 5'-monophosphoramidase activity
B1222_RS05060	COG1309	transcriptional regulator
B1222_RS05065	COG5002	protein histidine kinase activity
B1222_RS05085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B1222_RS05095	COG1454	alcohol dehydrogenase
B1222_RS05095	COG1012	belongs to the aldehyde dehydrogenase family
B1222_RS05105	COG0746	molybdenum cofactor guanylyltransferase activity
B1222_RS05115	COG2146	nitrite reductase [NAD(P)H] activity
B1222_RS05130	COG0419	ATPase involved in DNA repair
B1222_RS05135	COG0419	ATPase involved in DNA repair
B1222_RS05140	COG0420	3'-5' exonuclease activity
B1222_RS05145	COG1074	ATP-dependent DNA helicase activity
B1222_RS05180	COG1283	sodium-dependent phosphate transmembrane transporter activity
B1222_RS05190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1222_RS05195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1222_RS05200	COG1994	Peptidase M50
B1222_RS05225	COG0443	Heat shock 70 kDa protein
B1222_RS05235	COG1420	regulation of RNA biosynthetic process
B1222_RS05250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1222_RS05275	COG0268	Binds directly to 16S ribosomal RNA
B1222_RS05280	COG1466	dna polymerase III delta subunit
B1222_RS05295	COG1136	(ABC) transporter
B1222_RS05295	COG0577	efflux transmembrane transporter activity
B1222_RS05320	COG0658	competence protein
B1222_RS05320	COG2333	competence protein COMEC
B1222_RS05340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1222_RS05350	COG2226	methyltransferase
B1222_RS05355	COG2996	Protein conserved in bacteria
B1222_RS05360	COG0799	negative regulation of ribosome biogenesis
B1222_RS05365	COG1713	HD superfamily hydrolase involved in NAD metabolism
B1222_RS05370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1222_RS05375	COG1534	Rna-binding protein
B1222_RS05385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B1222_RS05395	COG1305	Transglutaminase-like
B1222_RS05405	COG2801	Transposase and inactivated derivatives
B1222_RS05410	COG1305	Transglutaminase-like
B1222_RS05430	COG0714	Associated with various cellular activities
B1222_RS05440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1222_RS05450	COG2323	membrane
B1222_RS05465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B1222_RS05475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1222_RS05505	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1222_RS05510	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1222_RS05515	COG1024	Enoyl-CoA hydratase
B1222_RS05530	COG1024	Enoyl-CoA hydratase
B1222_RS05535	COG2050	protein possibly involved in aromatic compounds catabolism
B1222_RS05545	COG1012	belongs to the aldehyde dehydrogenase family
B1222_RS05550	COG2151	metal-sulfur cluster biosynthetic enzyme
B1222_RS05565	COG3396	Phenylacetate-CoA oxygenase
B1222_RS05590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B1222_RS05625	COG2814	Major facilitator Superfamily
B1222_RS05630	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1222_RS05645	COG0602	queuosine metabolic process
B1222_RS05655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1222_RS05675	COG1472	Belongs to the glycosyl hydrolase 3 family
B1222_RS05685	COG2972	Histidine kinase
B1222_RS05715	COG1597	lipid kinase activity
B1222_RS05720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1222_RS05765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B1222_RS05770	COG0095	Lipoate-protein ligase
B1222_RS05775	COG0768	penicillin binding
B1222_RS05785	COG0840	transmembrane signaling receptor activity
B1222_RS05790	COG2801	Transposase and inactivated derivatives
B1222_RS05800	COG0826	peptidase U32
B1222_RS05805	COG0826	peptidase U32
B1222_RS05810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1222_RS05820	COG3906	Belongs to the UPF0473 family
B1222_RS05830	COG4472	Bacterial protein of unknown function (DUF965)
B1222_RS05865	COG1104	cysteine desulfurase activity
B1222_RS05870	COG1959	2 iron, 2 sulfur cluster binding
B1222_RS05875	COG0482	sulfurtransferase activity
B1222_RS05885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1222_RS05890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1222_RS05895	COG0124	histidyl-tRNA synthetase
B1222_RS05900	COG1733	regulation of RNA biosynthetic process
B1222_RS05905	COG0534	Mate efflux family protein
B1222_RS05915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1222_RS05920	COG1490	D-aminoacyl-tRNA deacylase activity
B1222_RS05925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1222_RS05935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1222_RS05950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1222_RS05955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1222_RS05955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1222_RS05970	COG2323	membrane
B1222_RS05980	COG1862	Preprotein translocase
B1222_RS05990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1222_RS06000	COG0632	four-way junction helicase activity
B1222_RS06005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1222_RS06020	COG3942	CHAP domain
B1222_RS06020	COG1388	LysM domain
B1222_RS06025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1222_RS06030	COG0077	Prephenate dehydratase
B1222_RS06035	COG0083	homoserine kinase activity
B1222_RS06040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B1222_RS06050	COG4492	Belongs to the UPF0735 family
B1222_RS06055	COG1051	belongs to the nudix hydrolase family
B1222_RS06065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1222_RS06070	COG3290	protein histidine kinase activity
B1222_RS06075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1222_RS06085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1222_RS06090	COG1530	ribonuclease E activity
B1222_RS06095	COG1994	Peptidase M50
B1222_RS06110	COG2894	cell division
B1222_RS06115	COG0850	regulation of cytokinetic process
B1222_RS06135	COG2003	Belongs to the UPF0758 family
B1222_RS06150	COG0424	maF-like protein
B1222_RS06160	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS06175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1222_RS06180	COG0285	dihydrofolate synthase activity
B1222_RS06190	COG1388	LysM domain
B1222_RS06195	COG0564	pseudouridine synthase activity
B1222_RS06205	COG1072	(Pantothenic acid kinase))
B1222_RS06210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1222_RS06215	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1222_RS06230	COG0113	porphobilinogen synthase activity
B1222_RS06250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1222_RS06265	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B1222_RS06275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1222_RS06285	COG1067	ATP-dependent peptidase activity
B1222_RS06285	COG0470	DNA polymerase III
B1222_RS06290	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS06290	COG2247	cell wall binding repeat
B1222_RS06300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1222_RS06305	COG0740	serine-type endopeptidase activity
B1222_RS06325	COG2843	Capsule synthesis protein
B1222_RS06335	COG3428	Bacterial PH domain
B1222_RS06340	COG3428	Bacterial PH domain
B1222_RS06365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1222_RS06375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B1222_RS06385	COG2801	Transposase and inactivated derivatives
B1222_RS06400	COG2076	Multidrug Resistance protein
B1222_RS06405	COG2076	Multidrug Resistance protein
B1222_RS06410	COG1309	transcriptional regulator
B1222_RS06475	COG1278	Cold shock
B1222_RS06485	COG1272	protein, Hemolysin III
B1222_RS06495	COG3328	transposase activity
B1222_RS06505	COG2197	response regulator
B1222_RS06540	COG1396	sequence-specific DNA binding
B1222_RS06550	COG0305	Participates in initiation and elongation during chromosome replication
B1222_RS06565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1222_RS06615	COG3646	Phage regulatory protein
B1222_RS06715	COG3953	SLT domain
B1222_RS06715	COG5280	Phage tail tape measure protein TP901
B1222_RS06780	COG0740	serine-type endopeptidase activity
B1222_RS06810	COG1598	PFAM Uncharacterised protein family UPF0150
B1222_RS06820	COG2197	response regulator
B1222_RS06825	COG2233	PERMEase
B1222_RS06830	COG0167	dihydroorotate dehydrogenase activity
B1222_RS06840	COG2801	Transposase and inactivated derivatives
B1222_RS06845	COG0167	dihydroorotate dehydrogenase activity
B1222_RS06850	COG0543	2 iron, 2 sulfur cluster binding
B1222_RS06855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1222_RS06860	COG1215	transferase activity, transferring glycosyl groups
B1222_RS06865	COG0463	Glycosyl transferase, family 2
B1222_RS06870	COG0463	Glycosyl transferase, family 2
B1222_RS06880	COG1216	Glycosyl transferase, family 2
B1222_RS06895	COG1086	Polysaccharide biosynthesis protein
B1222_RS06925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B1222_RS06960	COG1376	ErfK ybiS ycfS ynhG family protein
B1222_RS06970	COG0688	phosphatidylethanolamine metabolic process
B1222_RS06975	COG2223	nitrite transmembrane transporter activity
B1222_RS06980	COG1309	transcriptional regulator
B1222_RS06990	COG2801	Transposase and inactivated derivatives
B1222_RS06995	COG1956	GAF domain-containing protein
B1222_RS07000	COG2207	Transcriptional regulator
B1222_RS07065	COG0300	oxidoreductase activity
B1222_RS07080	COG5002	protein histidine kinase activity
B1222_RS07085	COG0647	UMP catabolic process
B1222_RS07090	COG0583	DNA-binding transcription factor activity
B1222_RS07105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1222_RS07110	COG1053	succinate dehydrogenase
B1222_RS07115	COG2009	succinate dehydrogenase
B1222_RS07130	COG0569	domain protein
B1222_RS07135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1222_RS07145	COG0322	excinuclease ABC activity
B1222_RS07160	COG0840	transmembrane signaling receptor activity
B1222_RS07165	COG1484	DNA-dependent DNA replication
B1222_RS07180	COG3253	May function as heme-dependent peroxidase
B1222_RS07190	COG1252	NADH dehydrogenase
B1222_RS07195	COG0492	ferredoxin-NADP+ reductase activity
B1222_RS07225	COG0596	Alpha beta hydrolase
B1222_RS07240	COG0316	Belongs to the HesB IscA family
B1222_RS07250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1222_RS07265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B1222_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS07280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1222_RS07285	COG1612	heme a metabolic process
B1222_RS07295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1222_RS07315	COG2244	polysaccharide biosynthetic process
B1222_RS07325	COG2839	Protein conserved in bacteria
B1222_RS07330	COG0561	phosphatase activity
B1222_RS07355	COG1215	transferase activity, transferring glycosyl groups
B1222_RS07375	COG2801	Transposase and inactivated derivatives
B1222_RS07380	COG1346	cytolysis
B1222_RS07390	COG0583	DNA-binding transcription factor activity
B1222_RS07395	COG2188	Transcriptional regulator
B1222_RS07425	COG0109	protoheme IX farnesyltransferase activity
B1222_RS07430	COG0840	transmembrane signaling receptor activity
B1222_RS07445	COG1988	membrane-bound metal-dependent
B1222_RS07460	COG0180	Tryptophanyl-tRNA synthetase
B1222_RS07470	COG3341	Caulimovirus viroplasmin
B1222_RS07470	COG0328	RNA-DNA hybrid ribonuclease activity
B1222_RS07495	COG2801	Transposase and inactivated derivatives
B1222_RS07560	COG3328	transposase activity
B1222_RS07610	COG3328	transposase activity
B1222_RS07655	COG1191	sigma factor activity
B1222_RS07685	COG1061	Type III restriction enzyme res subunit
B1222_RS07720	COG2002	toxin-antitoxin pair type II binding
B1222_RS07745	COG3620	sequence-specific DNA binding
B1222_RS07755	COG4974	Belongs to the 'phage' integrase family
B1222_RS07775	COG3093	addiction module antidote protein HigA
B1222_RS07790	COG2346	COG2346, Truncated hemoglobins
B1222_RS07795	COG3314	Sporulation integral membrane protein YlbJ
B1222_RS07800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1222_RS07805	COG4470	Protein conserved in bacteria
B1222_RS07810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1222_RS07815	COG0739	heme binding
B1222_RS07845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1222_RS07850	COG0569	domain protein
B1222_RS07865	COG0438	transferase activity, transferring glycosyl groups
B1222_RS07870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1222_RS07880	COG0577	efflux transmembrane transporter activity
B1222_RS07885	COG0577	efflux transmembrane transporter activity
B1222_RS07890	COG1136	(ABC) transporter
B1222_RS07895	COG1653	transport
B1222_RS07900	COG0395	ABC-type sugar transport system, permease component
B1222_RS07905	COG4209	transmembrane transport
B1222_RS07915	COG2207	Transcriptional regulator
B1222_RS07915	COG4753	response regulator
B1222_RS07920	COG2972	Histidine kinase
B1222_RS07925	COG0383	alpha-mannosidase activity
B1222_RS07935	COG0383	alpha-mannosidase activity
B1222_RS07940	COG5002	protein histidine kinase activity
B1222_RS07950	COG0745	RESPONSE REGULATOR receiver
B1222_RS07955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B1222_RS07965	COG0454	-acetyltransferase
B1222_RS07965	COG0456	acetyltransferase
B1222_RS07970	COG2197	response regulator
B1222_RS07975	COG4585	Histidine kinase
B1222_RS07980	COG2801	Transposase and inactivated derivatives
B1222_RS07990	COG4585	Histidine kinase
B1222_RS07995	COG4758	membrane
B1222_RS08010	COG2258	MOSC domain
B1222_RS08140	COG0735	belongs to the Fur family
B1222_RS08155	COG1595	DNA-templated transcription, initiation
B1222_RS08160	COG0456	acetyltransferase
B1222_RS08160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B1222_RS08165	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1222_RS08170	COG0154	amidase activity
B1222_RS08175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1222_RS08200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1222_RS08225	COG1309	transcriptional regulator
B1222_RS08230	COG1511	domain protein
B1222_RS08270	COG1301	dicarboxylic acid transport
B1222_RS08285	COG0025	NhaP-type Na H and K H
B1222_RS08300	COG4990	cell redox homeostasis
B1222_RS08310	COG1525	nuclease
B1222_RS08315	COG2860	membrane
B1222_RS08325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1222_RS08330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS08330	COG1263	PTS System
B1222_RS08360	COG2807	transmembrane transport
B1222_RS08365	COG2186	Transcriptional regulator
B1222_RS08375	COG0840	transmembrane signaling receptor activity
B1222_RS08395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1222_RS08410	COG1191	sigma factor activity
B1222_RS08445	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1222_RS08455	COG3328	transposase activity
B1222_RS08530	COG0450	alkyl hydroperoxide reductase
B1222_RS08570	COG1131	(ABC) transporter
B1222_RS08605	COG3328	transposase activity
B1222_RS08630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1222_RS08640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1222_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS08655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1222_RS08665	COG0842	Transport permease protein
B1222_RS08670	COG1131	(ABC) transporter
B1222_RS08710	COG3586	endonuclease activity
B1222_RS08750	COG3328	transposase activity
B1222_RS08795	COG1131	(ABC) transporter
B1222_RS08800	COG1404	Belongs to the peptidase S8 family
B1222_RS08820	COG0840	transmembrane signaling receptor activity
B1222_RS08860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1222_RS08865	COG1597	lipid kinase activity
B1222_RS08875	COG4496	protein, YerC YecD
B1222_RS08890	COG1470	cell adhesion involved in biofilm formation
B1222_RS08895	COG3011	Protein conserved in bacteria
B1222_RS08915	COG2312	Erythromycin esterase
B1222_RS08920	COG1132	(ABC) transporter
B1222_RS08945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1222_RS08950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1222_RS08955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1222_RS08965	COG0047	phosphoribosylformylglycinamidine synthase activity
B1222_RS08970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1222_RS08975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1222_RS08985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1222_RS08990	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1222_RS09000	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1222_RS09005	COG2801	Transposase and inactivated derivatives
B1222_RS09015	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1222_RS09020	COG0673	inositol 2-dehydrogenase activity
B1222_RS09030	COG3962	Belongs to the TPP enzyme family
B1222_RS09050	COG3718	enzyme involved in inositol metabolism
B1222_RS09055	COG1609	Transcriptional regulator
B1222_RS09075	COG2252	PERMEase
B1222_RS09100	COG0519	Catalyzes the synthesis of GMP from XMP
B1222_RS09100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1222_RS09115	COG2801	Transposase and inactivated derivatives
B1222_RS09130	COG1846	Transcriptional regulator
B1222_RS09140	COG0726	polysaccharide deacetylase
B1222_RS09145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1222_RS09155	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1222_RS09175	COG0483	inositol monophosphate 1-phosphatase activity
B1222_RS09190	COG4294	response to UV
B1222_RS09205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1222_RS09210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B1222_RS09215	COG1414	Transcriptional regulator
B1222_RS09225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1222_RS09230	COG0302	gtp cyclohydrolase
B1222_RS09250	COG3557	Belongs to the UPF0374 family
B1222_RS09255	COG0456	acetyltransferase
B1222_RS09260	COG1174	glycine betaine transport
B1222_RS09265	COG1732	Glycine betaine
B1222_RS09275	COG1125	glycine betaine transport
B1222_RS09275	COG0517	IMP dehydrogenase activity
B1222_RS09280	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B1222_RS09285	COG1486	melibiose metabolic process
B1222_RS09295	COG1609	Transcriptional regulator
B1222_RS09300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1222_RS09320	COG1131	(ABC) transporter
B1222_RS09330	COG2801	Transposase and inactivated derivatives
B1222_RS09350	COG0736	holo-[acyl-carrier-protein] synthase activity
B1222_RS09355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B1222_RS09360	COG1131	(ABC) transporter
B1222_RS09365	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1222_RS09385	COG1842	Phage shock protein A
B1222_RS09390	COG1983	PspC domain protein
B1222_RS09395	COG1842	Phage shock protein A
B1222_RS09415	COG2081	HI0933 family
B1222_RS09425	COG2801	Transposase and inactivated derivatives
B1222_RS09445	COG2081	HI0933 family
B1222_RS09460	COG4473	ABC transporter
B1222_RS09475	COG2801	Transposase and inactivated derivatives
B1222_RS09480	COG3328	transposase activity
B1222_RS09495	COG0745	RESPONSE REGULATOR receiver
B1222_RS09500	COG3850	Histidine kinase
B1222_RS09500	COG5002	protein histidine kinase activity
B1222_RS09540	COG2801	Transposase and inactivated derivatives
B1222_RS09555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1222_RS09560	COG0673	inositol 2-dehydrogenase activity
B1222_RS09590	COG0640	Transcriptional regulator
B1222_RS09595	COG3832	glyoxalase III activity
B1222_RS09600	COG4824	toxin secretion phage lysis holin
B1222_RS09615	COG1191	sigma factor activity
B1222_RS09620	COG3328	transposase activity
B1222_RS09630	COG0425	Belongs to the sulfur carrier protein TusA family
B1222_RS09635	COG3328	transposase activity
B1222_RS09655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1222_RS09675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1222_RS09680	COG3973	AAA domain
B1222_RS09690	COG2814	Major facilitator Superfamily
B1222_RS09700	COG1668	transmembrane transport
B1222_RS09705	COG4152	abc transporter atp-binding protein
B1222_RS09710	COG3328	transposase activity
B1222_RS09720	COG3336	cytochrome c oxidase
B1222_RS09750	COG0194	GDP metabolic process
B1222_RS09755	COG1413	lyase activity
B1222_RS09775	COG2801	Transposase and inactivated derivatives
B1222_RS09780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1222_RS09795	COG1136	(ABC) transporter
B1222_RS09845	COG1131	(ABC) transporter
B1222_RS09860	COG0671	phosphoesterase, PA-phosphatase related
B1222_RS09865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1222_RS09870	COG0352	thiamine-phosphate diphosphorylase activity
B1222_RS09875	COG0351	phosphomethylpyrimidine kinase
B1222_RS09880	COG2022	thiamine diphosphate biosynthetic process
B1222_RS09885	COG2104	thiamine diphosphate biosynthetic process
B1222_RS09895	COG0352	thiamine-phosphate diphosphorylase activity
B1222_RS09920	COG1595	DNA-templated transcription, initiation
B1222_RS09945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1222_RS09955	COG0720	synthase
B1222_RS09965	COG0018	arginyl-trna synthetase
B1222_RS09970	COG0675	Transposase, IS605 OrfB family
B1222_RS09975	COG2755	lipolytic protein G-D-S-L family
B1222_RS09975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1222_RS09990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1222_RS10000	COG1252	NADH dehydrogenase
B1222_RS10070	COG3328	transposase activity
B1222_RS10090	COG5002	protein histidine kinase activity
B1222_RS10100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1222_RS10110	COG0826	peptidase U32
B1222_RS10115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B1222_RS10125	COG1122	ATPase activity
B1222_RS10185	COG2801	Transposase and inactivated derivatives
B1222_RS10245	COG2801	Transposase and inactivated derivatives
B1222_RS10260	COG3716	PTS system mannose fructose sorbose family IID component
B1222_RS10270	COG2188	Transcriptional regulator
B1222_RS10275	COG1959	2 iron, 2 sulfur cluster binding
B1222_RS10290	COG0475	glutathione-regulated potassium exporter activity
B1222_RS10300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1222_RS10300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1222_RS10310	COG1033	growth of symbiont in host cell
B1222_RS10310	COG2409	Drug exporters of the RND superfamily
B1222_RS10315	COG1846	Transcriptional regulator
B1222_RS10325	COG2323	membrane
B1222_RS10330	COG0840	transmembrane signaling receptor activity
B1222_RS10335	COG0789	Transcriptional regulator
B1222_RS10345	COG2329	Antibiotic biosynthesis monooxygenase
B1222_RS10350	COG3397	chitin binding
B1222_RS10360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1222_RS10375	COG0535	radical SAM domain protein
B1222_RS10380	COG1266	CAAX protease self-immunity
B1222_RS10385	COG1131	(ABC) transporter
B1222_RS10405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1222_RS10470	COG3409	Peptidoglycan-binding domain 1 protein
B1222_RS10485	COG3483	tryptophan 2,3-dioxygenase activity
B1222_RS10490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B1222_RS10600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1222_RS10610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B1222_RS10620	COG2801	Transposase and inactivated derivatives
B1222_RS10625	COG5662	AntiSigma factor
B1222_RS10630	COG1595	DNA-templated transcription, initiation
B1222_RS10635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1222_RS10660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B1222_RS10670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1222_RS10770	COG0489	protein tyrosine kinase activity
B1222_RS10775	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS10785	COG0175	sulfate reduction
B1222_RS10790	COG0791	NLP P60 protein
B1222_RS10790	COG1388	LysM domain
B1222_RS10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1222_RS10800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1222_RS10805	COG0101	tRNA pseudouridine synthase activity
B1222_RS10810	COG0203	ribosomal protein L17
B1222_RS10815	COG0202	RNA polymerase activity
B1222_RS10820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1222_RS10825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1222_RS10830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1222_RS10835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1222_RS10840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B1222_RS10845	COG0024	Methionine aminopeptidase
B1222_RS10850	COG0563	adenylate kinase activity
B1222_RS10855	COG0201	protein transport
B1222_RS10860	COG0200	Binds to the 23S rRNA
B1222_RS10865	COG1841	ribosomal large subunit assembly
B1222_RS10870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1222_RS10875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1222_RS10880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1222_RS10885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1222_RS10890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1222_RS10895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1222_RS10900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1222_RS10905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1222_RS10910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1222_RS10915	COG0255	Belongs to the universal ribosomal protein uL29 family
B1222_RS10920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1222_RS10925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1222_RS10930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1222_RS10935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1222_RS10940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1222_RS10945	COG0089	rRNA binding
B1222_RS10950	COG0088	Forms part of the polypeptide exit tunnel
B1222_RS10955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1222_RS10960	COG0051	transcription antitermination factor activity, RNA binding
B1222_RS10965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1222_RS10970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1222_RS10975	COG0049	tRNA binding
B1222_RS10980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1222_RS10985	COG1358	cellular component organization or biogenesis
B1222_RS10990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1222_RS10995	COG0085	RNA polymerase activity
B1222_RS11005	COG2813	Specifically methylates the guanine in position
B1222_RS11010	COG0222	ribosome binding
B1222_RS11015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1222_RS11020	COG0081	regulation of translation
B1222_RS11025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1222_RS11035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1222_RS11040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1222_RS11050	COG3688	RNA-binding protein containing a PIN domain
B1222_RS11055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1222_RS11060	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B1222_RS11065	COG0215	cysteine-tRNA ligase activity
B1222_RS11070	COG1045	serine acetyltransferase
B1222_RS11075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1222_RS11080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1222_RS11085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1222_RS11090	COG4956	integral membrane protein (PIN domain superfamily)
B1222_RS11100	COG1183	phosphatidylcholine synthase activity
B1222_RS11105	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B1222_RS11110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B1222_RS11115	COG0542	response to heat
B1222_RS11120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B1222_RS11125	COG3880	PFAM UvrB UvrC protein
B1222_RS11170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1222_RS11175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1222_RS11185	COG5002	protein histidine kinase activity
B1222_RS11195	COG0254	rRNA binding
B1222_RS11220	COG0504	CTP synthase activity
B1222_RS11225	COG3343	RNA polymerase activity
B1222_RS11235	COG0018	arginyl-trna synthetase
B1222_RS11245	COG0010	Belongs to the arginase family
B1222_RS11250	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1222_RS11255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1222_RS11285	COG1846	Transcriptional regulator
B1222_RS11290	COG0477	Major facilitator Superfamily
B1222_RS11300	COG0514	ATP-dependent DNA helicase (RecQ)
B1222_RS11315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1222_RS11405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1222_RS11405	COG3153	acetyltransferase
B1222_RS11430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B1222_RS11435	COG4977	sequence-specific DNA binding
B1222_RS11440	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1222_RS11445	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1222_RS11455	COG1744	ABC transporter substrate-binding protein PnrA-like
B1222_RS11460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1222_RS11470	COG1132	(ABC) transporter
B1222_RS11475	COG1132	(ABC) transporter
B1222_RS11480	COG0656	L-ascorbic acid biosynthetic process
B1222_RS11495	COG1131	(ABC) transporter
B1222_RS11525	COG1801	Protein of unknown function DUF72
B1222_RS11530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1222_RS11535	COG1349	DNA-binding transcription factor activity
B1222_RS11545	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1222_RS11550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1222_RS11570	COG0531	amino acid
B1222_RS11605	COG1131	(ABC) transporter
B1222_RS11630	COG1136	(ABC) transporter
B1222_RS11635	COG0577	efflux transmembrane transporter activity
B1222_RS11640	COG2181	nitrate reductase activity
B1222_RS11645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B1222_RS11650	COG1140	nitrate reductase beta subunit
B1222_RS11670	COG0303	'Molybdopterin
B1222_RS11675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1222_RS11680	COG2223	nitrite transmembrane transporter activity
B1222_RS11690	COG2197	response regulator
B1222_RS11695	COG4585	Histidine kinase
B1222_RS11700	COG0314	molybdopterin synthase activity
B1222_RS11705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1222_RS11710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1222_RS11715	COG0351	phosphomethylpyrimidine kinase
B1222_RS11720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B1222_RS11725	COG2116	formate transmembrane transporter activity
B1222_RS11735	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1222_RS11800	COG3069	C4-dicarboxylate transmembrane transporter activity
B1222_RS11810	COG1609	Transcriptional regulator
B1222_RS11815	COG0628	permease
B1222_RS11825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1222_RS11835	COG2814	Major facilitator Superfamily
B1222_RS11840	COG1346	cytolysis
B1222_RS11845	COG1380	Effector of murein hydrolase LrgA
B1222_RS11850	COG3279	Response regulator of the LytR AlgR family
B1222_RS11855	COG3275	phosphorelay sensor kinase activity
B1222_RS11885	COG0667	Aldo Keto reductase
B1222_RS11895	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1222_RS11960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1222_RS11995	COG1216	Glycosyl transferase, family 2
B1222_RS12015	COG0438	transferase activity, transferring glycosyl groups
B1222_RS12025	COG0438	transferase activity, transferring glycosyl groups
B1222_RS12030	COG1216	Glycosyl transferase, family 2
B1222_RS12035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1222_RS12040	COG4106	trans-aconitate 2-methyltransferase activity
B1222_RS12045	COG0596	Alpha beta hydrolase
B1222_RS12050	COG0156	8-amino-7-oxononanoate synthase activity
B1222_RS12060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1222_RS12085	COG0531	amino acid
B1222_RS12100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B1222_RS12110	COG1609	Transcriptional regulator
B1222_RS12125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1222_RS12130	COG2801	Transposase and inactivated derivatives
B1222_RS12145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1222_RS12155	COG4863	YycH protein
B1222_RS12160	COG5002	protein histidine kinase activity
B1222_RS12165	COG0745	RESPONSE REGULATOR receiver
B1222_RS12170	COG0741	lytic transglycosylase activity
B1222_RS12170	COG1196	nuclear chromosome segregation
B1222_RS12170	COG0739	heme binding
B1222_RS12190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1222_RS12195	COG0305	Participates in initiation and elongation during chromosome replication
B1222_RS12205	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B1222_RS12245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1222_RS12250	COG0629	single-stranded DNA binding
B1222_RS12255	COG0360	Binds together with S18 to 16S ribosomal RNA
B1222_RS12275	COG4481	Protein conserved in bacteria
B1222_RS12280	COG0668	transmembrane transport
B1222_RS12305	COG1475	DNA binding
B1222_RS12310	COG1192	Involved in chromosome partitioning
B1222_RS12315	COG1475	DNA binding
B1222_RS12320	COG0357	Ribosomal RNA small subunit methyltransferase G
B1222_RS12325	COG0445	tRNA wobble uridine modification
B1222_RS12335	COG1847	R3H domain protein
B1222_RS12340	COG0706	membrane insertase activity
B1222_RS12350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1222_RS12355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1222_RS12360	COG0592	DNA-directed DNA polymerase activity
B1222_RS12365	COG2501	S4 domain
B1222_RS12370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1222_RS12385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1222_RS12390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1222_RS12410	COG0517	IMP dehydrogenase activity
B1222_RS12410	COG0516	GMP reductase activity
B1222_RS12415	COG1686	Belongs to the peptidase S11 family
B1222_RS12430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1222_RS12485	COG0590	tRNA wobble adenosine to inosine editing
B1222_RS12510	COG0012	GTP binding
B1222_RS12515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1222_RS12520	COG2890	protein-(glutamine-N5) methyltransferase activity
B1222_RS12535	COG1971	Probably functions as a manganese efflux pump
B1222_RS12540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1222_RS12545	COG0698	ribose 5-phosphate isomerase
B1222_RS12565	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1222_RS12585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1222_RS12590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1222_RS12595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1222_RS12600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1222_RS12605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1222_RS12610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1222_RS12615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1222_RS12620	COG1595	DNA-templated transcription, initiation
B1222_RS12635	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1222_RS12640	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1222_RS12645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1222_RS12650	COG0649	NAD binding
B1222_RS12655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1222_RS12660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1222_RS12665	COG0839	Belongs to the complex I subunit 6 family
B1222_RS12670	COG0713	ATP synthesis coupled electron transport
B1222_RS12675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1222_RS12685	COG1007	ATP synthesis coupled electron transport
B1222_RS12700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1222_RS12705	COG2385	sporulation resulting in formation of a cellular spore
B1222_RS12715	COG1609	Transcriptional regulator
B1222_RS12720	COG1077	Cell shape determining protein MreB Mrl
B1222_RS12725	COG4786	Flagellar basal body rod
B1222_RS12740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1222_RS12745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1222_RS12750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1222_RS12765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1222_RS12770	COG3693	PFAM glycoside hydrolase, family 10
B1222_RS12785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1222_RS12805	COG2197	response regulator
B1222_RS12815	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B1222_RS12820	COG1040	competence protein
B1222_RS12850	COG2801	Transposase and inactivated derivatives
B1222_RS12860	COG1131	(ABC) transporter
B1222_RS12885	COG1256	bacterial-type flagellum assembly
B1222_RS12885	COG4786	Flagellar basal body rod
B1222_RS12890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1222_RS12900	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B1222_RS12905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1222_RS12910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1222_RS12925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1222_RS12935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B1222_RS12955	COG2801	Transposase and inactivated derivatives
B1222_RS12960	COG1278	Cold shock
B1222_RS12965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B1222_RS12995	COG0653	protein targeting
B1222_RS13000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1222_RS13005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1222_RS13010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1222_RS13015	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1222_RS13020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1222_RS13025	COG2801	Transposase and inactivated derivatives
B1222_RS13035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1222_RS13040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1222_RS13045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1222_RS13050	COG0137	argininosuccinate synthase activity
B1222_RS13055	COG0165	Argininosuccinate lyase
B1222_RS13060	COG2720	vancomycin resistance protein
B1222_RS13065	COG2884	Cell division ATP-binding protein ftsE
B1222_RS13070	COG2177	Part of the ABC transporter FtsEX involved in
B1222_RS13075	COG1196	nuclear chromosome segregation
B1222_RS13075	COG0741	lytic transglycosylase activity
B1222_RS13075	COG0739	heme binding
B1222_RS13080	COG3409	Peptidoglycan-binding domain 1 protein
B1222_RS13080	COG0793	Belongs to the peptidase S41A family
B1222_RS13085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1222_RS13095	COG1360	Flagellar Motor Protein
B1222_RS13105	COG0556	nucleotide-excision repair
B1222_RS13110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1222_RS13120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1222_RS13130	COG1082	Xylose isomerase domain protein TIM barrel
B1222_RS13135	COG0840	transmembrane signaling receptor activity
B1222_RS13140	COG0826	peptidase U32
B1222_RS13160	COG1120	ATPase activity
B1222_RS13205	COG1131	(ABC) transporter
B1222_RS13210	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B1222_RS13215	COG0210	DNA helicase
B1222_RS13220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1222_RS13260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1222_RS13265	COG3870	Protein conserved in bacteria
B1222_RS13275	COG0470	DNA polymerase III
B1222_RS13280	COG1774	PSP1 C-terminal conserved region
B1222_RS13285	COG4467	Involved in initiation control of chromosome replication
B1222_RS13290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B1222_RS13295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B1222_RS13300	COG2002	toxin-antitoxin pair type II binding
B1222_RS13310	COG0084	hydrolase, TatD family'
B1222_RS13315	COG4473	ABC transporter
B1222_RS13320	COG1131	(ABC) transporter
B1222_RS13325	COG3584	3D domain protein
B1222_RS13325	COG3583	domain protein
B1222_RS13335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1222_RS13345	COG4466	Protein conserved in bacteria
B1222_RS13355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1222_RS13365	COG0251	oxidation-reduction process
B1222_RS13370	COG2088	sporulation resulting in formation of a cellular spore
B1222_RS13375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1222_RS13380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1222_RS13400	COG0193	aminoacyl-tRNA hydrolase activity
B1222_RS13410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1222_RS13415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1222_RS13425	COG2002	toxin-antitoxin pair type II binding
B1222_RS13430	COG2244	polysaccharide biosynthetic process
B1222_RS13435	COG3956	TIGRFAM MazG family protein
B1222_RS13440	COG0776	regulation of translation
B1222_RS13445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B1222_RS13455	COG2801	Transposase and inactivated derivatives
B1222_RS13475	COG1098	S1 RNA binding domain
B1222_RS13480	COG2208	phosphoserine phosphatase activity
B1222_RS13485	COG2304	oxidoreductase activity
B1222_RS13490	COG0515	serine threonine protein kinase
B1222_RS13505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1222_RS13510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1222_RS13515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B1222_RS13520	COG0157	Belongs to the NadC ModD family
B1222_RS13525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1222_RS13530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B1222_RS13535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1222_RS13540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1222_RS13550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B1222_RS13555	COG0512	Glutamine amidotransferase of anthranilate synthase
B1222_RS13560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1222_RS13565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1222_RS13570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1222_RS13575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1222_RS13580	COG1396	sequence-specific DNA binding
B1222_RS13585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1222_RS13590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1222_RS13595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1222_RS13665	COG0011	TIGRFAM Protein of
B1222_RS13685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1222_RS13690	COG2508	Transcriptional regulator
B1222_RS13695	COG3842	ATPase activity
B1222_RS13715	COG0110	maltose O-acetyltransferase activity
B1222_RS13720	COG2801	Transposase and inactivated derivatives
B1222_RS13740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1222_RS13745	COG0131	Imidazoleglycerol-phosphate dehydratase
B1222_RS13755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1222_RS13760	COG0107	imidazoleglycerol-phosphate synthase activity
B1222_RS13765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1222_RS13765	COG0140	phosphoribosyl-ATP diphosphatase activity
B1222_RS13770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1222_RS13775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1222_RS13780	COG0457	Tetratricopeptide repeat
B1222_RS13790	COG1940	carbohydrate kinase activity
B1222_RS13795	COG1660	Displays ATPase and GTPase activities
B1222_RS13800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1222_RS13805	COG1481	regulation of sporulation
B1222_RS13810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS13830	COG4555	ABC transporter
B1222_RS13845	COG0740	serine-type endopeptidase activity
B1222_RS13865	COG0126	phosphoglycerate kinase activity
B1222_RS13870	COG0149	triose-phosphate isomerase activity
B1222_RS13875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1222_RS13880	COG0148	phosphopyruvate hydratase activity
B1222_RS13890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1222_RS13895	COG0557	exoribonuclease II activity
B1222_RS13900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1222_RS13920	COG0556	nucleotide-excision repair
B1222_RS13935	COG3328	transposase activity
B1222_RS13955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B1222_RS13960	COG2514	catechol 2,3-dioxygenase activity
B1222_RS13970	COG2514	catechol 2,3-dioxygenase activity
B1222_RS13975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1222_RS13995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1222_RS14000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B1222_RS14000	COG0662	Cupin 2, conserved barrel domain protein
B1222_RS14020	COG1278	Cold shock
B1222_RS14030	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B1222_RS14035	COG1349	DNA-binding transcription factor activity
B1222_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS14050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1222_RS14075	COG1131	(ABC) transporter
B1222_RS14100	COG0210	DNA helicase
B1222_RS14115	COG3328	transposase activity
B1222_RS14120	COG5002	protein histidine kinase activity
B1222_RS14125	COG5002	protein histidine kinase activity
B1222_RS14130	COG0745	RESPONSE REGULATOR receiver
B1222_RS14135	COG1418	mRNA catabolic process
B1222_RS14140	COG2879	small protein
B1222_RS14145	COG1966	Carbon starvation protein
B1222_RS14155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B1222_RS14195	COG1435	thymidine kinase activity
B1222_RS14205	COG1802	Transcriptional regulator
B1222_RS14210	COG0697	spore germination
B1222_RS14230	COG1793	dna ligase
B1222_RS14230	COG3285	dna ligase
B1222_RS14235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1222_RS14240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B1222_RS14255	COG1175	transmembrane transport
B1222_RS14260	COG0395	ABC-type sugar transport system, permease component
B1222_RS14265	COG3842	ATPase activity
B1222_RS14280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1222_RS14285	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1222_RS14300	COG0644	oxidoreductase
B1222_RS14300	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B1222_RS14310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS14310	COG3711	transcriptional antiterminator
B1222_RS14320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS14320	COG3711	transcriptional antiterminator
B1222_RS14340	COG0802	atpase or kinase
B1222_RS14345	COG1214	PFAM Peptidase M22, glycoprotease
B1222_RS14350	COG0456	acetyltransferase
B1222_RS14360	COG1929	Belongs to the glycerate kinase type-1 family
B1222_RS14380	COG0488	(ABC) transporter
B1222_RS14385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1222_RS14390	COG0315	cyclic pyranopterin monophosphate synthase activity
B1222_RS14395	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1222_RS14405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1222_RS14410	COG0805	protein transport
B1222_RS14420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1222_RS14425	COG0459	protein refolding
B1222_RS14505	COG0814	amino acid
B1222_RS14510	COG0697	spore germination
B1222_RS14530	COG3328	transposase activity
B1222_RS14630	COG0531	amino acid
B1222_RS14640	COG1757	Na H antiporter
B1222_RS14655	COG0531	amino acid
B1222_RS14665	COG0351	phosphomethylpyrimidine kinase
B1222_RS14675	COG4496	protein, YerC YecD
B1222_RS14710	COG1091	dTDP-4-dehydrorhamnose reductase activity
B1222_RS14795	COG2197	response regulator
B1222_RS14800	COG1131	(ABC) transporter
B1222_RS14825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B1222_RS14830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1222_RS14835	COG0864	Transcriptional regulator
B1222_RS14840	COG2337	Toxic component of a toxin-antitoxin (TA) module
B1222_RS14845	COG2183	response to ionizing radiation
B1222_RS14850	COG1595	DNA-templated transcription, initiation
B1222_RS14865	COG1404	Belongs to the peptidase S8 family
B1222_RS14885	COG3091	SprT-like family
B1222_RS14965	COG2801	Transposase and inactivated derivatives
B1222_RS15030	COG2814	Major facilitator Superfamily
B1222_RS15065	COG3711	transcriptional antiterminator
B1222_RS15070	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS15080	COG2801	Transposase and inactivated derivatives
B1222_RS15145	COG3293	Transposase
B1222_RS15180	COG1263	PTS System
B1222_RS15180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS15180	COG2190	(PTS) system
B1222_RS15200	COG2112	serine threonine protein kinase
B1222_RS15210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1222_RS15215	COG0788	formyltetrahydrofolate deformylase activity
B1222_RS15235	COG0166	Belongs to the GPI family
B1222_RS15240	COG1739	Uncharacterized protein family UPF0029
B1222_RS15305	COG1136	(ABC) transporter
B1222_RS15310	COG0577	efflux transmembrane transporter activity
B1222_RS15320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1222_RS15350	COG1876	peptidase activity
B1222_RS15355	COG0346	lactoylglutathione lyase activity
B1222_RS15375	COG1187	pseudouridine synthase activity
B1222_RS15385	COG1349	DNA-binding transcription factor activity
B1222_RS15395	COG2309	aminopeptidase activity
B1222_RS15405	COG1376	ErfK ybiS ycfS ynhG family protein
B1222_RS15425	COG1482	cell wall glycoprotein biosynthetic process
B1222_RS15430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B1222_RS15435	COG1242	4 iron, 4 sulfur cluster binding
B1222_RS15465	COG1215	transferase activity, transferring glycosyl groups
B1222_RS15475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1222_RS15480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1222_RS15485	COG0028	Belongs to the TPP enzyme family
B1222_RS15490	COG0440	acetolactate synthase activity
B1222_RS15495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1222_RS15500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1222_RS15515	COG1131	(ABC) transporter
B1222_RS15525	COG3328	transposase activity
B1222_RS15550	COG0450	alkyl hydroperoxide reductase
B1222_RS15555	COG0509	glycine decarboxylation via glycine cleavage system
B1222_RS15575	COG2801	Transposase and inactivated derivatives
B1222_RS15595	COG2801	Transposase and inactivated derivatives
B1222_RS15605	COG1191	sigma factor activity
B1222_RS15610	COG3693	PFAM glycoside hydrolase, family 10
B1222_RS15615	COG4191	Histidine kinase
B1222_RS15620	COG2801	Transposase and inactivated derivatives
B1222_RS15630	COG5002	protein histidine kinase activity
B1222_RS15645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1222_RS15650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1222_RS15670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1222_RS15680	COG2608	mercury ion transmembrane transporter activity
B1222_RS15690	COG4549	nuclear export factor GLE1
B1222_RS15695	COG2197	response regulator
B1222_RS15700	COG4585	Histidine kinase
B1222_RS15710	COG5566	PFAM Mor transcription activator
B1222_RS15715	COG1276	copper resistance
B1222_RS15715	COG2372	response to copper ion
B1222_RS15735	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B1222_RS15745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1222_RS15775	COG2801	Transposase and inactivated derivatives
B1222_RS15785	COG2801	Transposase and inactivated derivatives
B1222_RS15795	COG0667	Aldo Keto reductase
B1222_RS15815	COG2190	(PTS) system
B1222_RS15815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS15815	COG1263	PTS System
B1222_RS15820	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1222_RS15830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B1222_RS15855	COG1842	Phage shock protein A
B1222_RS15860	COG3766	membrane
B1222_RS15875	COG0477	Major facilitator Superfamily
B1222_RS15885	COG1522	sequence-specific DNA binding
B1222_RS15905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1222_RS15910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1222_RS15915	COG1120	ATPase activity
B1222_RS15920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1222_RS15930	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B1222_RS15935	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1222_RS15955	COG0564	pseudouridine synthase activity
B1222_RS15960	COG1393	Belongs to the ArsC family
B1222_RS15985	COG2801	Transposase and inactivated derivatives
B1222_RS15995	COG0667	Aldo Keto reductase
B1222_RS16005	COG1846	Transcriptional regulator
B1222_RS16010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B1222_RS16035	COG3766	membrane
B1222_RS16040	COG2322	membrane
B1222_RS16065	COG3344	reverse transcriptase
B1222_RS16090	COG0598	Magnesium transport protein CorA
B1222_RS16095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B1222_RS16105	COG0626	cystathionine gamma-synthase activity
B1222_RS16110	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
B1222_RS16125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1222_RS16130	COG3584	3D domain protein
B1222_RS16140	COG4758	membrane
B1222_RS16145	COG4585	Histidine kinase
B1222_RS16155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1222_RS16165	COG3850	Histidine kinase
B1222_RS16165	COG5002	protein histidine kinase activity
B1222_RS16175	COG2390	Transcriptional regulator
B1222_RS16190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1222_RS16200	COG2801	Transposase and inactivated derivatives
B1222_RS16210	COG0174	glutamine synthetase
B1222_RS16215	COG1285	pathogenesis
B1222_RS16235	COG2002	toxin-antitoxin pair type II binding
B1222_RS16245	COG0725	ABC transporter, periplasmic molybdate-binding protein
B1222_RS16250	COG4149	molybdate abc transporter
B1222_RS16255	COG0445	tRNA wobble uridine modification
B1222_RS16265	COG2766	serine protein kinase
B1222_RS16270	COG2766	serine protein kinase
B1222_RS16275	COG0392	lysyltransferase activity
B1222_RS16275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B1222_RS16285	COG2217	Heavy metal translocating P-type atpase
B1222_RS16305	COG0488	(ABC) transporter
B1222_RS16360	COG2719	SpoVR family
B1222_RS16365	COG2718	Belongs to the UPF0229 family
B1222_RS16370	COG4555	ABC transporter
B1222_RS16395	COG3328	transposase activity
B1222_RS16410	COG2363	Small membrane protein
B1222_RS16415	COG5002	protein histidine kinase activity
B1222_RS16430	COG2801	Transposase and inactivated derivatives
B1222_RS16445	COG3377	Domain of unknown function (DUF1805)
B1222_RS16450	COG4977	sequence-specific DNA binding
B1222_RS16455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1222_RS16465	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B1222_RS16470	COG0783	Belongs to the Dps family
B1222_RS16480	COG0396	ATPase activity
B1222_RS16485	COG0719	Fe-S assembly protein
B1222_RS16490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1222_RS16495	COG0822	iron-sulfur transferase activity
B1222_RS16500	COG0719	Fe-S assembly protein
B1222_RS16505	COG4974	Belongs to the 'phage' integrase family
B1222_RS16510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1222_RS16565	COG0629	single-stranded DNA binding
B1222_RS16580	COG1484	DNA-dependent DNA replication
B1222_RS16590	COG3331	DNA recombination
B1222_RS16665	COG4626	Terminase
B1222_RS16665	COG1802	Transcriptional regulator
B1222_RS16775	COG2801	Transposase and inactivated derivatives
B1222_RS16840	COG3227	Zinc metalloprotease (Elastase)
B1222_RS16875	COG2801	Transposase and inactivated derivatives
B1222_RS16945	COG3328	transposase activity
B1222_RS17040	COG0535	radical SAM domain protein
B1222_RS17045	COG1253	flavin adenine dinucleotide binding
B1222_RS17050	COG2801	Transposase and inactivated derivatives
B1222_RS17070	COG3546	catalase activity
B1222_RS17115	COG2801	Transposase and inactivated derivatives
B1222_RS17130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B1222_RS17135	COG1802	Transcriptional regulator
B1222_RS17140	COG0246	Mannitol dehydrogenase
B1222_RS17145	COG1312	Catalyzes the dehydration of D-mannonate
B1222_RS17155	COG1904	glucuronate isomerase
B1222_RS17160	COG0800	Aldolase
B1222_RS17170	COG3711	transcriptional antiterminator
B1222_RS17185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS17185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS17185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS17190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS17195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS17195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS17195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B1222_RS17200	COG1215	transferase activity, transferring glycosyl groups
B1222_RS17205	COG0463	Glycosyl transferase, family 2
B1222_RS17205	COG1216	Glycosyl transferase, family 2
B1222_RS17215	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1222_RS17220	COG2226	methyltransferase
B1222_RS17225	COG1272	protein, Hemolysin III
B1222_RS17240	COG1278	Cold shock
B1222_RS17290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B1222_RS17300	COG1388	LysM domain
B1222_RS17300	COG3584	3D domain protein
B1222_RS17310	COG0791	NLP P60 protein
B1222_RS17310	COG1388	LysM domain
B1222_RS17315	COG4824	toxin secretion phage lysis holin
B1222_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS17325	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS17330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B1222_RS17340	COG1737	Transcriptional regulator
B1222_RS17360	COG2268	Band 7 protein
B1222_RS17365	COG1585	Membrane protein implicated in regulation of membrane protease activity
B1222_RS17375	COG0463	Glycosyl transferase, family 2
B1222_RS17385	COG2076	Multidrug Resistance protein
B1222_RS17400	COG0189	ligase activity
B1222_RS17405	COG0189	ligase activity
B1222_RS17410	COG0189	ligase activity
B1222_RS17415	COG0189	ligase activity
B1222_RS17420	COG4399	Belongs to the UPF0754 family
B1222_RS17425	COG3679	Belongs to the UPF0342 family
B1222_RS17430	COG0604	alcohol dehydrogenase
B1222_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS17470	COG4109	DRTGG domain
B1222_RS17485	COG4585	Histidine kinase
B1222_RS17490	COG2197	response regulator
B1222_RS17525	COG0791	NLP P60 protein
B1222_RS17525	COG1388	LysM domain
B1222_RS17545	COG0587	DNA-directed DNA polymerase activity
B1222_RS17555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1222_RS17560	COG0825	malonyl-CoA metabolic process
B1222_RS17570	COG0824	Thioesterase
B1222_RS17580	COG0538	isocitrate dehydrogenase activity
B1222_RS17595	COG0726	polysaccharide deacetylase
B1222_RS17615	COG5002	protein histidine kinase activity
B1222_RS17630	COG0673	inositol 2-dehydrogenase activity
B1222_RS17635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1222_RS17640	COG0573	inorganic phosphate transmembrane transporter activity
B1222_RS17645	COG0581	inorganic phosphate transmembrane transporter activity
B1222_RS17665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1222_RS17705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1222_RS17710	COG1971	Probably functions as a manganese efflux pump
B1222_RS17715	COG0237	dephospho-CoA kinase activity
B1222_RS17720	COG0739	heme binding
B1222_RS17720	COG0741	lytic transglycosylase activity
B1222_RS17720	COG1196	nuclear chromosome segregation
B1222_RS17730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1222_RS17755	COG3711	transcriptional antiterminator
B1222_RS17765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS17765	COG1263	PTS System
B1222_RS17765	COG2190	(PTS) system
B1222_RS17795	COG1268	BioY protein
B1222_RS17800	COG1122	ATPase activity
B1222_RS17805	COG1122	ATPase activity
B1222_RS17810	COG2801	Transposase and inactivated derivatives
B1222_RS17820	COG0772	Belongs to the SEDS family
B1222_RS17850	COG4126	flavin adenine dinucleotide binding
B1222_RS17875	COG3409	Peptidoglycan-binding domain 1 protein
B1222_RS17925	COG1396	sequence-specific DNA binding
B1222_RS17985	COG4193	domain, Protein
B1222_RS18045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1222_RS18055	COG3328	transposase activity
B1222_RS18080	COG5577	PFAM Coat F domain
B1222_RS18110	COG4819	ethanolamine utilization protein
B1222_RS18115	COG4303	Ethanolamine ammonia lyase large subunit
B1222_RS18120	COG4302	ethanolamine ammonia-lyase activity
B1222_RS18125	COG4816	utilization protein
B1222_RS18135	COG1454	alcohol dehydrogenase
B1222_RS18135	COG1012	belongs to the aldehyde dehydrogenase family
B1222_RS18150	COG4869	propanediol catabolic process
B1222_RS18160	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B1222_RS18170	COG3192	ethanolamine utilization protein
B1222_RS18220	COG2445	Protein of unknown function DUF86
B1222_RS18250	COG0709	Synthesizes selenophosphate from selenide and ATP
B1222_RS18255	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B1222_RS18270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1222_RS18270	COG2207	Transcriptional regulator
B1222_RS18275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1222_RS18290	COG1486	melibiose metabolic process
B1222_RS18300	COG2801	Transposase and inactivated derivatives
B1222_RS18345	COG0789	Transcriptional regulator
B1222_RS18355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1222_RS18400	COG0024	Methionine aminopeptidase
B1222_RS18410	COG4844	belongs to the
B1222_RS18420	COG0116	Belongs to the methyltransferase superfamily
B1222_RS18430	COG2814	Major facilitator Superfamily
B1222_RS18435	COG5577	PFAM Coat F domain
B1222_RS18455	COG2252	PERMEase
B1222_RS18460	COG5416	Lipopolysaccharide assembly protein A domain
B1222_RS18470	COG0861	Integral membrane protein TerC family
B1222_RS18485	COG0217	transcriptional regulatory protein
B1222_RS18490	COG0778	Nitroreductase
B1222_RS18490	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B1222_RS18520	COG0431	NADPH-dependent FMN reductase
B1222_RS18525	COG1271	oxidase subunit
B1222_RS18530	COG1294	oxidase, subunit
B1222_RS18535	COG4988	ABC transporter
B1222_RS18540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B1222_RS18545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1222_RS18560	COG1309	transcriptional regulator
B1222_RS18575	COG0513	Belongs to the DEAD box helicase family
B1222_RS18590	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1222_RS18595	COG1494	fructose-1,6-bisphosphatase
B1222_RS18600	COG1914	H( )-stimulated, divalent metal cation uptake system
B1222_RS18610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B1222_RS18615	COG0583	DNA-binding transcription factor activity
B1222_RS18620	COG2738	Putative neutral zinc metallopeptidase
B1222_RS18630	COG2801	Transposase and inactivated derivatives
B1222_RS18650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1222_RS18655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1222_RS18660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1222_RS18665	COG1141	Ferredoxin
B1222_RS18685	COG2357	RelA SpoT domain protein
B1222_RS18700	COG0561	phosphatase activity
B1222_RS18705	COG0477	Major facilitator Superfamily
B1222_RS18720	COG3118	belongs to the thioredoxin family
B1222_RS18745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1222_RS18750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B1222_RS18755	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B1222_RS18765	COG1396	sequence-specific DNA binding
B1222_RS18775	COG0438	transferase activity, transferring glycosyl groups
B1222_RS18790	COG1105	Belongs to the carbohydrate kinase PfkB family
B1222_RS18800	COG1349	DNA-binding transcription factor activity
B1222_RS18810	COG0586	Pfam SNARE associated Golgi protein
B1222_RS18820	COG2801	Transposase and inactivated derivatives
B1222_RS18875	COG3279	Response regulator of the LytR AlgR family
B1222_RS18905	COG0535	radical SAM domain protein
B1222_RS18910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1222_RS18915	COG1131	(ABC) transporter
B1222_RS18945	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B1222_RS19010	COG1122	ATPase activity
B1222_RS19015	COG1760	l-serine dehydratase
B1222_RS19020	COG1760	l-serine dehydratase
B1222_RS19025	COG0814	amino acid
B1222_RS19030	COG2964	Protein conserved in bacteria
B1222_RS19040	COG2801	Transposase and inactivated derivatives
B1222_RS19045	COG2964	Protein conserved in bacteria
B1222_RS19060	COG0670	Belongs to the BI1 family
B1222_RS19085	COG0095	Lipoate-protein ligase
B1222_RS19120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1222_RS19145	COG2340	Cysteine-rich secretory protein family
B1222_RS19175	COG1078	dGTPase activity
B1222_RS19180	COG3328	transposase activity
B1222_RS19235	COG2247	cell wall binding repeat
B1222_RS19235	COG2385	sporulation resulting in formation of a cellular spore
B1222_RS19240	COG0506	proline dehydrogenase activity
B1222_RS19245	COG1012	belongs to the aldehyde dehydrogenase family
B1222_RS19255	COG1609	Transcriptional regulator
B1222_RS19275	COG0463	Glycosyl transferase, family 2
B1222_RS19325	COG3711	transcriptional antiterminator
B1222_RS19325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS19330	COG3964	amidohydrolase
B1222_RS19390	COG3328	transposase activity
B1222_RS19410	COG2801	Transposase and inactivated derivatives
B1222_RS19415	COG1368	sulfuric ester hydrolase activity
B1222_RS19430	COG1940	carbohydrate kinase activity
B1222_RS19450	COG0745	RESPONSE REGULATOR receiver
B1222_RS19465	COG0783	Belongs to the Dps family
B1222_RS19475	COG0247	lactate metabolic process
B1222_RS19485	COG1649	PFAM Uncharacterised BCR, COG1649
B1222_RS19485	COG0726	polysaccharide deacetylase
B1222_RS19495	COG1115	amino acid carrier protein
B1222_RS19500	COG0604	alcohol dehydrogenase
B1222_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS19500	COG3321	synthase
B1222_RS19505	COG2861	carbohydrate metabolic process
B1222_RS19520	COG0697	spore germination
B1222_RS19530	COG0735	belongs to the Fur family
B1222_RS19535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1222_RS19545	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1222_RS19550	COG1121	(ABC) transporter
B1222_RS19555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1222_RS19560	COG0785	Cytochrome C biogenesis protein
B1222_RS19570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1222_RS19575	COG1321	iron dependent repressor
B1222_RS19580	COG1752	Esterase of the alpha-beta hydrolase superfamily
B1222_RS19590	COG3872	metal-dependent enzyme
B1222_RS19600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1222_RS19610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1222_RS19620	COG2707	UPF0756 membrane protein
B1222_RS19625	COG2045	Belongs to the ComB family
B1222_RS19640	COG3854	ATPases associated with a variety of cellular activities
B1222_RS19680	COG0511	ligase activity, forming carbon-carbon bonds
B1222_RS19685	COG0439	Biotin carboxylase
B1222_RS19690	COG1302	Protein conserved in bacteria
B1222_RS19705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1222_RS19710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1222_RS19715	COG1570	exodeoxyribonuclease VII activity
B1222_RS19720	COG1722	exodeoxyribonuclease VII activity
B1222_RS19735	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B1222_RS19745	COG1438	arginine binding
B1222_RS19750	COG0497	DNA recombination
B1222_RS19760	COG0745	RESPONSE REGULATOR receiver
B1222_RS19775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS19775	COG1263	PTS System
B1222_RS19790	COG4209	transmembrane transport
B1222_RS19795	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1222_RS19800	COG1121	(ABC) transporter
B1222_RS19805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1222_RS19805	COG1321	iron dependent repressor
B1222_RS19810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1222_RS19815	COG1114	Component of the transport system for branched-chain amino acids
B1222_RS19845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1222_RS19855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1222_RS19860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1222_RS19865	COG0022	dehydrogenase e1 component
B1222_RS19875	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1222_RS19890	COG1379	DNA repair
B1222_RS19895	COG1300	Membrane
B1222_RS19900	COG0735	belongs to the Fur family
B1222_RS19915	COG4974	Belongs to the 'phage' integrase family
B1222_RS19950	COG1131	(ABC) transporter
B1222_RS19960	COG1595	DNA-templated transcription, initiation
B1222_RS19965	COG1686	Belongs to the peptidase S11 family
B1222_RS19970	COG1366	Belongs to the anti-sigma-factor antagonist family
B1222_RS19975	COG2172	sigma factor antagonist activity
B1222_RS20015	COG2181	nitrate reductase activity
B1222_RS20025	COG2155	Conserved Protein
B1222_RS20040	COG0697	spore germination
B1222_RS20050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1222_RS20065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1222_RS20065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1222_RS20070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1222_RS20075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1222_RS20080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1222_RS20090	COG3874	Sporulation protein YtfJ
B1222_RS20100	COG1686	Belongs to the peptidase S11 family
B1222_RS20105	COG2715	membrane protein required for spore maturation
B1222_RS20110	COG0700	Nucleoside recognition
B1222_RS20120	COG1187	pseudouridine synthase activity
B1222_RS20125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1222_RS20130	COG1333	cytochrome c biogenesis protein
B1222_RS20135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1222_RS20140	COG0745	RESPONSE REGULATOR receiver
B1222_RS20145	COG5002	protein histidine kinase activity
B1222_RS20165	COG1266	CAAX protease self-immunity
B1222_RS20180	COG4862	establishment of competence for transformation
B1222_RS20190	COG2339	peptidase activity
B1222_RS20195	COG2959	enzyme of heme biosynthesis
B1222_RS20210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1222_RS20220	COG0539	negative regulation of cytoplasmic translation
B1222_RS20225	COG1304	FMN binding
B1222_RS20240	COG1160	GTP binding
B1222_RS20245	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1222_RS20295	COG0776	regulation of translation
B1222_RS20325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B1222_RS20330	COG0163	prenyltransferase activity
B1222_RS20335	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
B1222_RS20345	COG0105	UTP biosynthetic process
B1222_RS20350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1222_RS20355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1222_RS20360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1222_RS20380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1222_RS20385	COG0134	indole-3-glycerol-phosphate synthase activity
B1222_RS20395	COG0133	tryptophan synthase activity
B1222_RS20400	COG0159	tryptophan synthase activity
B1222_RS20410	COG0287	Prephenate dehydrogenase
B1222_RS20415	COG0406	alpha-ribazole phosphatase activity
B1222_RS20425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B1222_RS20440	COG0723	plastoquinol--plastocyanin reductase activity
B1222_RS20465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1222_RS20470	COG1694	Mazg nucleotide pyrophosphohydrolase
B1222_RS20490	COG1803	Methylglyoxal synthase
B1222_RS20495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B1222_RS20500	COG0438	transferase activity, transferring glycosyl groups
B1222_RS20505	COG0617	tRNA 3'-terminal CCA addition
B1222_RS20510	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B1222_RS20510	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B1222_RS20520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1222_RS20525	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1222_RS20540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B1222_RS20545	COG0306	phosphate transporter
B1222_RS20550	COG1392	Phosphate transport regulator
B1222_RS20555	COG0402	S-adenosylhomocysteine deaminase activity
B1222_RS20580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B1222_RS20585	COG0017	Asparaginyl-tRNA synthetase
B1222_RS20600	COG0235	Class ii aldolase
B1222_RS20610	COG1850	ribulose-bisphosphate carboxylase activity
B1222_RS20630	COG0436	Aminotransferase
B1222_RS20635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1222_RS20660	COG2172	sigma factor antagonist activity
B1222_RS20665	COG1191	sigma factor activity
B1222_RS20670	COG0583	DNA-binding transcription factor activity
B1222_RS20680	COG0066	3-isopropylmalate dehydratase activity
B1222_RS20690	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1222_RS20710	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B1222_RS20715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B1222_RS20730	COG1131	(ABC) transporter
B1222_RS20740	COG0187	DNA topoisomerase II activity
B1222_RS20760	COG0667	Aldo Keto reductase
B1222_RS20765	COG1129	ABC transporter
B1222_RS20765	COG0842	Transport permease protein
B1222_RS20770	COG1131	(ABC) transporter
B1222_RS20785	COG1725	Transcriptional regulator
B1222_RS20905	COG3328	transposase activity
B1222_RS20950	COG3328	transposase activity
B1222_RS21000	COG3328	transposase activity
B1222_RS21010	COG1846	Transcriptional regulator
B1222_RS21015	COG0564	pseudouridine synthase activity
B1222_RS21035	COG2801	Transposase and inactivated derivatives
B1222_RS21040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1222_RS21045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B1222_RS21055	COG0297	glycogen (starch) synthase activity
B1222_RS21090	COG1649	PFAM Uncharacterised BCR, COG1649
B1222_RS21115	COG0549	Belongs to the carbamate kinase family
B1222_RS21120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1222_RS21140	COG2801	Transposase and inactivated derivatives
B1222_RS21155	COG0628	permease
B1222_RS21200	COG1122	ATPase activity
B1222_RS21205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1222_RS21205	COG2207	Transcriptional regulator
B1222_RS21210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1222_RS21215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1222_RS21225	COG3397	chitin binding
B1222_RS21240	COG2819	hydrolase of the alpha beta superfamily
B1222_RS21265	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B1222_RS21280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B1222_RS21280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1222_RS21305	COG2801	Transposase and inactivated derivatives
B1222_RS21345	COG0730	response to heat
B1222_RS21365	COG4109	DRTGG domain
B1222_RS21370	COG2224	Isocitrate lyase
B1222_RS21425	COG0288	reversible hydration of carbon dioxide
B1222_RS21430	COG4918	Iron-sulphur cluster biosynthesis
B1222_RS21460	COG4129	membrane
B1222_RS21485	COG2136	Putative SAM-dependent methyltransferase
B1222_RS21485	COG2521	methyltransferase
B1222_RS21490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1222_RS21495	COG1923	regulation of RNA biosynthetic process
B1222_RS21500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1222_RS21505	COG4499	WXG100 protein secretion system (Wss), protein YukC
B1222_RS21505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1222_RS21535	COG2801	Transposase and inactivated derivatives
B1222_RS21540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B1222_RS21545	COG0095	Lipoate-protein ligase
B1222_RS21550	COG0464	growth
B1222_RS21555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1222_RS21560	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B1222_RS21565	COG0789	Transcriptional regulator
B1222_RS21570	COG0174	glutamine synthetase
B1222_RS21610	COG2801	Transposase and inactivated derivatives
B1222_RS21680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1222_RS21690	COG4224	UPF0291 protein
B1222_RS21695	COG1011	Hydrolase
B1222_RS21700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B1222_RS21705	COG1410	methionine synthase
B1222_RS21705	COG0646	methionine synthase
B1222_RS21710	COG1234	tRNA 3'-trailer cleavage
B1222_RS21720	COG2801	Transposase and inactivated derivatives
B1222_RS21740	COG1205	dead DEAH box helicase
B1222_RS21740	COG1111	helicase
B1222_RS21745	COG3359	exonuclease
B1222_RS21750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1222_RS21755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1222_RS21765	COG1119	ATPase activity
B1222_RS21770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B1222_RS21780	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B1222_RS21785	COG3328	transposase activity
B1222_RS21855	COG0488	(ABC) transporter
B1222_RS21870	COG0488	(ABC) transporter
B1222_RS21875	COG0488	(ABC) transporter
B1222_RS21890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1222_RS21915	COG1131	(ABC) transporter
B1222_RS21930	COG3328	transposase activity
B1222_RS21950	COG0463	Glycosyl transferase, family 2
B1222_RS22000	COG1607	acyl-coa hydrolase
B1222_RS22015	COG4208	sulfate ABC transporter
B1222_RS22020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1222_RS22025	COG5583	Uncharacterized small protein (DUF2292)
B1222_RS22045	COG1609	Transcriptional regulator
B1222_RS22050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1222_RS22055	COG2086	electron transfer activity
B1222_RS22060	COG1309	transcriptional regulator
B1222_RS22065	COG0247	lactate metabolic process
B1222_RS22065	COG2181	nitrate reductase activity
B1222_RS22070	COG1024	Enoyl-CoA hydratase
B1222_RS22070	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1222_RS22075	COG0183	Belongs to the thiolase family
B1222_RS22085	COG0318	PFAM AMP-dependent synthetase and ligase
B1222_RS22105	COG3328	transposase activity
B1222_RS22115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1222_RS22120	COG0765	amino acid transport
B1222_RS22125	COG0765	amino acid transport
B1222_RS22130	COG1473	amidohydrolase
B1222_RS22135	COG1272	protein, Hemolysin III
B1222_RS22145	COG0765	amino acid transport
B1222_RS22155	COG1307	EDD domain protein, DegV family
B1222_RS22160	COG1307	EDD domain protein, DegV family
B1222_RS22175	COG3711	transcriptional antiterminator
B1222_RS22195	COG0697	spore germination
B1222_RS22210	COG3681	Belongs to the UPF0597 family
B1222_RS22220	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1222_RS22225	COG1028	Short-chain dehydrogenase reductase Sdr
B1222_RS22230	COG1169	isochorismate synthase
B1222_RS22235	COG1021	2,3-dihydroxybenzoate-AMP ligase
B1222_RS22240	COG1535	isochorismatase
B1222_RS22240	COG3433	isochorismatase activity
B1222_RS22250	COG3251	PFAM MbtH domain protein
B1222_RS22290	COG0235	Class ii aldolase
B1222_RS22305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1222_RS22320	COG1192	Involved in chromosome partitioning
B1222_RS22330	COG0495	leucyl-tRNA aminoacylation
B1222_RS22390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1222_RS22400	COG5002	protein histidine kinase activity
B1222_RS22405	COG1940	carbohydrate kinase activity
B1222_RS22430	COG2801	Transposase and inactivated derivatives
B1222_RS22440	COG0572	uridine kinase
B1222_RS22470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1222_RS22475	COG1116	anion transmembrane transporter activity
B1222_RS22480	COG0084	hydrolase, TatD family'
B1222_RS22530	COG0129	dihydroxy-acid dehydratase activity
B1222_RS22540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1222_RS22565	COG2239	Acts as a magnesium transporter
B1222_RS22585	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1222_RS22605	COG1309	transcriptional regulator
B1222_RS22610	COG0477	Major facilitator Superfamily
B1222_RS22625	COG3328	transposase activity
B1222_RS22630	COG1368	sulfuric ester hydrolase activity
B1222_RS22660	COG1263	PTS System
B1222_RS22660	COG2190	(PTS) system
B1222_RS22660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B1222_RS22670	COG2801	Transposase and inactivated derivatives
B1222_RS22680	COG2707	UPF0756 membrane protein
B1222_RS22685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B1222_RS22690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1222_RS22700	COG0833	amino acid
B1222_RS22735	COG2801	Transposase and inactivated derivatives
B1222_RS22745	COG1649	PFAM Uncharacterised BCR, COG1649
B1222_RS22745	COG0726	polysaccharide deacetylase
B1222_RS22750	COG2814	Major facilitator Superfamily
B1222_RS22765	COG4555	ABC transporter
B1222_RS22780	COG1846	Transcriptional regulator
B1222_RS22785	COG2364	Membrane
B1222_RS22790	COG0528	UMP kinase activity
B1222_RS22800	COG1253	flavin adenine dinucleotide binding
B1222_RS22805	COG0384	phenazine biosynthesis protein PhzF
B1222_RS22820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1222_RS22825	COG0561	phosphatase activity
B1222_RS22845	COG1175	transmembrane transport
B1222_RS22870	COG1151	hydroxylamine reductase activity
B1222_RS22875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1222_RS22895	COG1686	Belongs to the peptidase S11 family
B1222_RS22905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS22905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1222_RS22905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1222_RS22925	COG2076	Multidrug Resistance protein
B1222_RS22930	COG2076	Multidrug Resistance protein
B1222_RS22975	COG1404	Belongs to the peptidase S8 family
B1222_RS22985	COG2801	Transposase and inactivated derivatives
B1222_RS23010	COG0494	nUDIX hydrolase
B1222_RS23020	COG1309	transcriptional regulator
B1222_RS23025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1222_RS23030	COG0765	amino acid transport
B1222_RS23075	COG3328	transposase activity
B1222_RS23085	COG4555	ABC transporter
B1222_RS23090	COG4122	O-methyltransferase activity