locus-tag	class	description
PPE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPE_RS00010	COG0592	DNA-directed DNA polymerase activity
PPE_RS00015	COG2501	S4 domain
PPE_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPE_RS00030	COG0187	DNA topoisomerase II activity
PPE_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PPE_RS00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPE_RS00080	COG1982	Orn Lys Arg decarboxylase major
PPE_RS00085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPE_RS00090	COG3870	Protein conserved in bacteria
PPE_RS00095	COG1728	Protein conserved in bacteria
PPE_RS00100	COG0470	DNA polymerase III
PPE_RS00105	COG1774	PSP1 C-terminal conserved region
PPE_RS00110	COG4467	Involved in initiation control of chromosome replication
PPE_RS00115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PPE_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PPE_RS00125	COG2002	toxin-antitoxin pair type II binding
PPE_RS00130	COG1078	dGTPase activity
PPE_RS00135	COG0084	hydrolase, TatD family'
PPE_RS00140	COG3583	domain protein
PPE_RS00140	COG3584	3D domain protein
PPE_RS00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PPE_RS00160	COG4466	Protein conserved in bacteria
PPE_RS00170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PPE_RS00175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPE_RS00180	COG2088	sporulation resulting in formation of a cellular spore
PPE_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPE_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PPE_RS00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PPE_RS00215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPE_RS00220	COG2002	toxin-antitoxin pair type II binding
PPE_RS00225	COG2244	polysaccharide biosynthetic process
PPE_RS00230	COG3956	TIGRFAM MazG family protein
PPE_RS00240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PPE_RS00260	COG1098	S1 RNA binding domain
PPE_RS00265	COG2208	phosphoserine phosphatase activity
PPE_RS00275	COG0515	serine threonine protein kinase
PPE_RS00290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPE_RS00300	COG0157	Belongs to the NadC ModD family
PPE_RS00305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PPE_RS00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPE_RS00325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PPE_RS00330	COG0512	Glutamine amidotransferase of anthranilate synthase
PPE_RS00335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPE_RS00340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PPE_RS00345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PPE_RS00350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PPE_RS00355	COG1396	sequence-specific DNA binding
PPE_RS00360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPE_RS00365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPE_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPE_RS00390	COG0318	PFAM AMP-dependent synthetase and ligase
PPE_RS00395	COG1012	belongs to the aldehyde dehydrogenase family
PPE_RS00400	COG0028	Belongs to the TPP enzyme family
PPE_RS00405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPE_RS00410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPE_RS00440	COG0516	GMP reductase activity
PPE_RS00440	COG0517	IMP dehydrogenase activity
PPE_RS00445	COG1686	Belongs to the peptidase S11 family
PPE_RS00485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPE_RS00490	COG0590	tRNA wobble adenosine to inosine editing
PPE_RS00495	COG5002	protein histidine kinase activity
PPE_RS00500	COG1187	pseudouridine synthase activity
PPE_RS00505	COG1360	Flagellar Motor Protein
PPE_RS00510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPE_RS00520	COG2154	pterin-4-alpha-carbinolamine dehydratase
PPE_RS00530	COG0791	NLP P60 protein
PPE_RS00550	COG2190	(PTS) system
PPE_RS00570	COG1357	PFAM Pentapeptide repeats (8 copies)
PPE_RS00590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPE_RS00595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PPE_RS00600	COG2211	Major facilitator Superfamily
PPE_RS00605	COG1132	(ABC) transporter
PPE_RS00615	COG0583	DNA-binding transcription factor activity
PPE_RS00625	COG0018	arginyl-trna synthetase
PPE_RS00635	COG0583	DNA-binding transcription factor activity
PPE_RS00640	COG3842	ATPase activity
PPE_RS00650	COG1177	transmembrane transport
PPE_RS00655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PPE_RS00660	COG1404	Belongs to the peptidase S8 family
PPE_RS00665	COG3343	RNA polymerase activity
PPE_RS00670	COG0504	CTP synthase activity
PPE_RS00675	COG2204	response regulator
PPE_RS00685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPE_RS00690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PPE_RS00700	COG0254	rRNA binding
PPE_RS00705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPE_RS00710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPE_RS00715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PPE_RS00800	COG2508	Transcriptional regulator
PPE_RS00805	COG3842	ATPase activity
PPE_RS00810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PPE_RS00815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPE_RS00820	COG0546	phosphoglycolate phosphatase activity
PPE_RS00825	COG0110	maltose O-acetyltransferase activity
PPE_RS00860	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PPE_RS00865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPE_RS00870	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PPE_RS00875	COG0131	Imidazoleglycerol-phosphate dehydratase
PPE_RS00880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PPE_RS00885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PPE_RS00890	COG0107	imidazoleglycerol-phosphate synthase activity
PPE_RS00895	COG0140	phosphoribosyl-ATP diphosphatase activity
PPE_RS00895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PPE_RS00900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PPE_RS00915	COG1940	carbohydrate kinase activity
PPE_RS00920	COG1660	Displays ATPase and GTPase activities
PPE_RS00925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PPE_RS00930	COG1481	regulation of sporulation
PPE_RS00935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS00950	COG0740	serine-type endopeptidase activity
PPE_RS00970	COG0126	phosphoglycerate kinase activity
PPE_RS00975	COG0149	triose-phosphate isomerase activity
PPE_RS00985	COG0148	phosphopyruvate hydratase activity
PPE_RS00990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPE_RS00995	COG0557	exoribonuclease II activity
PPE_RS01000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PPE_RS01005	COG4224	UPF0291 protein
PPE_RS01010	COG2259	Doxx family
PPE_RS01015	COG0346	lactoylglutathione lyase activity
PPE_RS01020	COG1216	Glycosyl transferase, family 2
PPE_RS01025	COG2188	Transcriptional regulator
PPE_RS01030	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PPE_RS01040	COG1842	Phage shock protein A
PPE_RS01045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPE_RS01050	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PPE_RS01055	COG4260	virion core protein, lumpy skin disease virus
PPE_RS01070	COG2207	Transcriptional regulator
PPE_RS01070	COG1917	Cupin 2, conserved barrel domain protein
PPE_RS01085	COG0534	Mate efflux family protein
PPE_RS01090	COG0604	alcohol dehydrogenase
PPE_RS01130	COG0583	DNA-binding transcription factor activity
PPE_RS01140	COG0662	Cupin 2, conserved barrel domain protein
PPE_RS01150	COG3250	beta-galactosidase activity
PPE_RS01170	COG2972	Histidine kinase
PPE_RS01175	COG2207	Transcriptional regulator
PPE_RS01175	COG4753	response regulator
PPE_RS01180	COG0572	uridine kinase
PPE_RS01200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPE_RS01205	COG4715	Zinc finger, swim domain protein
PPE_RS01225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPE_RS01230	COG1554	hydrolase, family 65, central catalytic
PPE_RS01235	COG1609	Transcriptional regulator
PPE_RS01240	COG2190	(PTS) system
PPE_RS01240	COG1263	PTS System
PPE_RS01240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS01260	COG1846	Transcriptional regulator
PPE_RS01265	COG0784	Response regulator, receiver
PPE_RS01270	COG4191	Histidine kinase
PPE_RS01295	COG0601	transmembrane transport
PPE_RS01300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS01305	COG0444	Belongs to the ABC transporter superfamily
PPE_RS01310	COG4608	Belongs to the ABC transporter superfamily
PPE_RS01325	COG3480	Lon protease (S16) C-terminal proteolytic domain
PPE_RS01340	COG1653	transport
PPE_RS01345	COG1175	transmembrane transport
PPE_RS01350	COG0395	ABC-type sugar transport system, permease component
PPE_RS01355	COG2207	Transcriptional regulator
PPE_RS01355	COG1917	Cupin 2, conserved barrel domain protein
PPE_RS01360	COG0673	inositol 2-dehydrogenase activity
PPE_RS01365	COG3338	carbonate dehydratase activity
PPE_RS01375	COG1733	regulation of RNA biosynthetic process
PPE_RS01380	COG2814	Major facilitator Superfamily
PPE_RS01385	COG0656	L-ascorbic acid biosynthetic process
PPE_RS01390	COG1609	Transcriptional regulator
PPE_RS01395	COG1621	beta-fructofuranosidase activity
PPE_RS01420	COG3152	Membrane
PPE_RS01425	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS01430	COG1278	Cold shock
PPE_RS01440	COG2267	carboxylic ester hydrolase activity
PPE_RS01460	COG1725	Transcriptional regulator
PPE_RS01465	COG1131	(ABC) transporter
PPE_RS01495	COG1609	Transcriptional regulator
PPE_RS01500	COG3459	Glycosyltransferase 36 associated
PPE_RS01510	COG1653	transport
PPE_RS01515	COG1175	transmembrane transport
PPE_RS01520	COG0395	ABC-type sugar transport system, permease component
PPE_RS01530	COG3119	arylsulfatase activity
PPE_RS01540	COG1132	(ABC) transporter
PPE_RS01545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPE_RS01575	COG0326	Molecular chaperone. Has ATPase activity
PPE_RS01585	COG0584	glycerophosphoryl diester phosphodiesterase
PPE_RS01595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPE_RS01605	COG0463	Glycosyl transferase, family 2
PPE_RS01610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PPE_RS01615	COG0745	RESPONSE REGULATOR receiver
PPE_RS01620	COG5002	protein histidine kinase activity
PPE_RS01625	COG1404	Belongs to the peptidase S8 family
PPE_RS01630	COG1227	inorganic diphosphatase activity
PPE_RS01635	COG0657	acetylesterase activity
PPE_RS01640	COG1846	Transcriptional regulator
PPE_RS01645	COG1793	dna ligase
PPE_RS01655	COG2322	membrane
PPE_RS01670	COG0395	ABC-type sugar transport system, permease component
PPE_RS01675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PPE_RS01675	COG3291	Pkd domain containing protein
PPE_RS01685	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PPE_RS01690	COG1737	Transcriptional regulator
PPE_RS01695	COG1940	carbohydrate kinase activity
PPE_RS01700	COG1233	COG1233 Phytoene dehydrogenase and related
PPE_RS01825	COG4585	Histidine kinase
PPE_RS01830	COG2197	response regulator
PPE_RS01840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPE_RS01865	COG1175	transmembrane transport
PPE_RS01875	COG2972	Histidine kinase
PPE_RS01880	COG4753	response regulator
PPE_RS01880	COG2207	Transcriptional regulator
PPE_RS01885	COG0583	DNA-binding transcription factor activity
PPE_RS01890	COG0163	prenyltransferase activity
PPE_RS01895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPE_RS01915	COG5492	domain, Protein
PPE_RS01915	COG4932	domain protein
PPE_RS01920	COG1760	l-serine dehydratase
PPE_RS01925	COG1760	l-serine dehydratase
PPE_RS01940	COG4608	Belongs to the ABC transporter superfamily
PPE_RS01945	COG0601	transmembrane transport
PPE_RS01960	COG0583	DNA-binding transcription factor activity
PPE_RS01965	COG0765	amino acid transport
PPE_RS01970	COG0765	amino acid transport
PPE_RS01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS02000	COG1917	Cupin 2, conserved barrel domain protein
PPE_RS02000	COG2207	Transcriptional regulator
PPE_RS02005	COG2733	membrane
PPE_RS02015	COG0778	Nitroreductase
PPE_RS02020	COG1733	regulation of RNA biosynthetic process
PPE_RS02030	COG4549	nuclear export factor GLE1
PPE_RS02035	COG1276	copper resistance
PPE_RS02035	COG2372	response to copper ion
PPE_RS02040	COG2199	diguanylate cyclase activity
PPE_RS02040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPE_RS02050	COG2814	Major facilitator Superfamily
PPE_RS02060	COG2608	mercury ion transmembrane transporter activity
PPE_RS02065	COG2217	Heavy metal translocating P-type atpase
PPE_RS02070	COG0778	Nitroreductase
PPE_RS02075	COG0084	hydrolase, TatD family'
PPE_RS02085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPE_RS02100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPE_RS02105	COG3871	stress protein (general stress protein 26)
PPE_RS02110	COG0737	Belongs to the 5'-nucleotidase family
PPE_RS02130	COG4221	oxidoreductase activity
PPE_RS02140	COG0366	Alpha amylase catalytic
PPE_RS02145	COG0560	Phosphoserine phosphatase
PPE_RS02155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPE_RS02160	COG2011	ABC-type metal ion transport system permease component
PPE_RS02165	COG0789	Transcriptional regulator
PPE_RS02170	COG0667	Aldo Keto reductase
PPE_RS02180	COG2972	Histidine kinase
PPE_RS02180	COG0745	RESPONSE REGULATOR receiver
PPE_RS02185	COG3279	Response regulator of the LytR AlgR family
PPE_RS02195	COG0745	RESPONSE REGULATOR receiver
PPE_RS02200	COG2205	protein histidine kinase activity
PPE_RS02230	COG0515	serine threonine protein kinase
PPE_RS02235	COG1070	Carbohydrate kinase
PPE_RS02250	COG0024	Methionine aminopeptidase
PPE_RS02260	COG4846	Membrane protein involved in cytochrome C biogenesis
PPE_RS02265	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PPE_RS02270	COG0778	Nitroreductase
PPE_RS02275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PPE_RS02275	COG0392	lysyltransferase activity
PPE_RS02285	COG2814	Major facilitator Superfamily
PPE_RS02290	COG2706	6-phosphogluconolactonase activity
PPE_RS02310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PPE_RS02310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PPE_RS02320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPE_RS02325	COG0840	transmembrane signaling receptor activity
PPE_RS02330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPE_RS02335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPE_RS02340	COG0011	TIGRFAM Protein of
PPE_RS02350	COG2244	polysaccharide biosynthetic process
PPE_RS02415	COG0662	Cupin 2, conserved barrel domain protein
PPE_RS02420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPE_RS02430	COG0412	Dienelactone hydrolase
PPE_RS02435	COG0640	Transcriptional regulator
PPE_RS02450	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPE_RS02465	COG2770	Histidine kinase
PPE_RS02465	COG3437	response regulator, receiver
PPE_RS02470	COG3437	response regulator, receiver
PPE_RS02470	COG2205	protein histidine kinase activity
PPE_RS02470	COG3850	Histidine kinase
PPE_RS02470	COG4999	Histidine kinase
PPE_RS02475	COG0702	epimerase
PPE_RS02480	COG0251	oxidation-reduction process
PPE_RS02485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPE_RS02495	COG0385	Bile acid
PPE_RS02500	COG1902	pentaerythritol trinitrate reductase activity
PPE_RS02505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPE_RS02510	COG2207	Transcriptional regulator
PPE_RS02510	COG4753	response regulator
PPE_RS02515	COG2972	Histidine kinase
PPE_RS02545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPE_RS02555	COG1876	peptidase activity
PPE_RS02570	COG0754	glutathionylspermidine amidase activity
PPE_RS02575	COG3766	membrane
PPE_RS02600	COG3290	protein histidine kinase activity
PPE_RS02600	COG0840	transmembrane signaling receptor activity
PPE_RS02610	COG0300	oxidoreductase activity
PPE_RS02615	COG0789	Transcriptional regulator
PPE_RS02620	COG0673	inositol 2-dehydrogenase activity
PPE_RS02630	COG2814	Major facilitator Superfamily
PPE_RS02635	COG1846	Transcriptional regulator
PPE_RS02640	COG1309	transcriptional regulator
PPE_RS02645	COG2814	Major facilitator Superfamily
PPE_RS02665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPE_RS02670	COG2357	RelA SpoT domain protein
PPE_RS02675	COG1854	S-ribosylhomocysteine lyase activity
PPE_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS02685	COG1464	Belongs to the NlpA lipoprotein family
PPE_RS02690	COG2207	Transcriptional regulator
PPE_RS02700	COG2972	Histidine kinase
PPE_RS02705	COG2207	Transcriptional regulator
PPE_RS02705	COG4753	response regulator
PPE_RS02710	COG4209	transmembrane transport
PPE_RS02715	COG0395	ABC-type sugar transport system, permease component
PPE_RS02725	COG4124	Belongs to the glycosyl hydrolase 26 family
PPE_RS02730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPE_RS02735	COG0210	DNA helicase
PPE_RS02770	COG1970	mechanosensitive ion channel activity
PPE_RS02775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPE_RS02780	COG1595	DNA-templated transcription, initiation
PPE_RS02800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PPE_RS02810	COG0024	Methionine aminopeptidase
PPE_RS02845	COG1131	(ABC) transporter
PPE_RS02850	COG4152	abc transporter atp-binding protein
PPE_RS02855	COG1668	transmembrane transport
PPE_RS02890	COG1846	Transcriptional regulator
PPE_RS02895	COG0457	Tetratricopeptide repeat
PPE_RS02920	COG0738	Major facilitator superfamily
PPE_RS02925	COG0110	maltose O-acetyltransferase activity
PPE_RS02930	COG1396	sequence-specific DNA binding
PPE_RS02940	COG0366	Alpha amylase catalytic
PPE_RS02945	COG1263	PTS System
PPE_RS02945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS02950	COG2188	Transcriptional regulator
PPE_RS02960	COG0531	amino acid
PPE_RS02965	COG0697	spore germination
PPE_RS02970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPE_RS02975	COG2146	nitrite reductase [NAD(P)H] activity
PPE_RS02985	COG3693	PFAM glycoside hydrolase, family 10
PPE_RS02995	COG0697	spore germination
PPE_RS03000	COG0531	amino acid
PPE_RS03010	COG1695	Transcriptional regulator
PPE_RS03015	COG3479	Phenolic acid decarboxylase
PPE_RS03020	COG1733	regulation of RNA biosynthetic process
PPE_RS03030	COG0745	RESPONSE REGULATOR receiver
PPE_RS03035	COG5002	protein histidine kinase activity
PPE_RS03040	COG1183	phosphatidylcholine synthase activity
PPE_RS03045	COG0586	Pfam SNARE associated Golgi protein
PPE_RS03050	COG3223	Belongs to the PsiE family
PPE_RS03055	COG0628	permease
PPE_RS03065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PPE_RS03070	COG2315	Protein conserved in bacteria
PPE_RS03075	COG0778	Nitroreductase
PPE_RS03080	COG0346	lactoylglutathione lyase activity
PPE_RS03115	COG1874	Beta-galactosidase
PPE_RS03120	COG2972	Histidine kinase
PPE_RS03125	COG2207	Transcriptional regulator
PPE_RS03125	COG4753	response regulator
PPE_RS03180	COG0789	Transcriptional regulator
PPE_RS03185	COG2814	Major facilitator Superfamily
PPE_RS03190	COG0589	response to stress
PPE_RS03195	COG1012	belongs to the aldehyde dehydrogenase family
PPE_RS03200	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS03220	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS03230	COG2002	toxin-antitoxin pair type II binding
PPE_RS03235	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS03240	COG1733	regulation of RNA biosynthetic process
PPE_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS03265	COG0789	Transcriptional regulator
PPE_RS03285	COG1956	GAF domain-containing protein
PPE_RS03305	COG4721	ABC-type cobalt transport system, permease component
PPE_RS03310	COG1122	ATPase activity
PPE_RS03315	COG0477	Major facilitator Superfamily
PPE_RS03320	COG1621	beta-fructofuranosidase activity
PPE_RS03325	COG1621	beta-fructofuranosidase activity
PPE_RS03330	COG1846	Transcriptional regulator
PPE_RS03340	COG1113	amino acid transport
PPE_RS03345	COG1280	lysine exporter protein (LysE YggA)
PPE_RS03350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PPE_RS03355	COG2081	HI0933 family
PPE_RS03360	COG5002	protein histidine kinase activity
PPE_RS03370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPE_RS03385	COG1194	a g-specific adenine glycosylase
PPE_RS03395	COG2207	Transcriptional regulator
PPE_RS03410	COG2318	DinB family
PPE_RS03420	COG0456	acetyltransferase
PPE_RS03430	COG0328	RNA-DNA hybrid ribonuclease activity
PPE_RS03435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PPE_RS03445	COG0302	gtp cyclohydrolase
PPE_RS03450	COG0095	Lipoate-protein ligase
PPE_RS03455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PPE_RS03465	COG1414	Transcriptional regulator
PPE_RS03470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPE_RS03475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS03490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PPE_RS03510	COG4294	response to UV
PPE_RS03515	COG0483	inositol monophosphate 1-phosphatase activity
PPE_RS03525	COG2972	Histidine kinase
PPE_RS03530	COG4753	response regulator
PPE_RS03530	COG2207	Transcriptional regulator
PPE_RS03535	COG1653	transport
PPE_RS03540	COG1175	transmembrane transport
PPE_RS03545	COG0395	ABC-type sugar transport system, permease component
PPE_RS03550	COG2755	lipolytic protein G-D-S-L family
PPE_RS03555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PPE_RS03565	COG0697	spore germination
PPE_RS03570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPE_RS03575	COG1316	TRANSCRIPTIONal
PPE_RS03580	COG4555	ABC transporter
PPE_RS03595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPE_RS03610	COG0586	Pfam SNARE associated Golgi protein
PPE_RS03615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPE_RS03615	COG0519	Catalyzes the synthesis of GMP from XMP
PPE_RS03620	COG3340	Belongs to the peptidase S51 family
PPE_RS03625	COG0673	inositol 2-dehydrogenase activity
PPE_RS03630	COG0583	DNA-binding transcription factor activity
PPE_RS03640	COG1846	Transcriptional regulator
PPE_RS03645	COG0604	alcohol dehydrogenase
PPE_RS03650	COG2252	PERMEase
PPE_RS03670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPE_RS03680	COG0252	asparaginase activity
PPE_RS03685	COG3326	Membrane
PPE_RS03690	COG0589	response to stress
PPE_RS03695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PPE_RS03700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PPE_RS03705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PPE_RS03710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PPE_RS03715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPE_RS03720	COG0047	phosphoribosylformylglycinamidine synthase activity
PPE_RS03725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPE_RS03730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PPE_RS03735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PPE_RS03740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PPE_RS03750	COG0151	Belongs to the GarS family
PPE_RS03755	COG1309	transcriptional regulator
PPE_RS03760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS03765	COG0765	amino acid transport
PPE_RS03770	COG1126	abc transporter atp-binding protein
PPE_RS03785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS03790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS03795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PPE_RS03805	COG3290	protein histidine kinase activity
PPE_RS03810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PPE_RS03815	COG0656	L-ascorbic acid biosynthetic process
PPE_RS03825	COG0640	Transcriptional regulator
PPE_RS03830	COG0400	carboxylic ester hydrolase activity
PPE_RS03840	COG1653	transport
PPE_RS03845	COG1175	transmembrane transport
PPE_RS03850	COG0395	ABC-type sugar transport system, permease component
PPE_RS03855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PPE_RS03860	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS03865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS03870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS03895	COG3384	dioxygenase
PPE_RS03905	COG1470	cell adhesion involved in biofilm formation
PPE_RS03910	COG1392	Phosphate transport regulator
PPE_RS03915	COG0306	phosphate transporter
PPE_RS03920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS03930	COG0598	Magnesium transport protein CorA
PPE_RS03940	COG4496	protein, YerC YecD
PPE_RS03950	COG1597	lipid kinase activity
PPE_RS03955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPE_RS03965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPE_RS03995	COG4974	Belongs to the 'phage' integrase family
PPE_RS04020	COG1846	Transcriptional regulator
PPE_RS04030	COG0702	epimerase
PPE_RS04080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPE_RS04090	COG1309	transcriptional regulator
PPE_RS04100	COG5426	von Willebrand factor, type A
PPE_RS04120	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PPE_RS04160	COG0673	inositol 2-dehydrogenase activity
PPE_RS04175	COG1609	Transcriptional regulator
PPE_RS04185	COG1129	ABC transporter
PPE_RS04190	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPE_RS04200	COG1082	Xylose isomerase domain protein TIM barrel
PPE_RS04205	COG1063	alcohol dehydrogenase
PPE_RS04230	COG1113	amino acid transport
PPE_RS04235	COG1064	alcohol dehydrogenase
PPE_RS04240	COG0789	Transcriptional regulator
PPE_RS04260	COG0778	Nitroreductase
PPE_RS04265	COG1733	regulation of RNA biosynthetic process
PPE_RS04270	COG2801	Transposase and inactivated derivatives
PPE_RS04285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPE_RS04290	COG3239	Fatty acid desaturase
PPE_RS04295	COG4585	Histidine kinase
PPE_RS04300	COG2197	response regulator
PPE_RS04305	COG1428	Deoxynucleoside kinase
PPE_RS04310	COG1428	Deoxynucleoside kinase
PPE_RS04315	COG0673	inositol 2-dehydrogenase activity
PPE_RS04335	COG2814	Major facilitator Superfamily
PPE_RS04340	COG0583	DNA-binding transcription factor activity
PPE_RS04345	COG2814	Major facilitator Superfamily
PPE_RS04350	COG0710	3-dehydroquinate dehydratase activity
PPE_RS04355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PPE_RS04380	COG2814	Major facilitator Superfamily
PPE_RS04385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPE_RS04390	COG4989	oxidoreductase activity
PPE_RS04405	COG3541	Predicted nucleotidyltransferase
PPE_RS04415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPE_RS04430	COG4172	Belongs to the ABC transporter superfamily
PPE_RS04440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPE_RS04445	COG2011	ABC-type metal ion transport system permease component
PPE_RS04470	COG0673	inositol 2-dehydrogenase activity
PPE_RS04475	COG1472	Belongs to the glycosyl hydrolase 3 family
PPE_RS04500	COG4474	Belongs to the UPF0398 family
PPE_RS04520	COG2116	formate transmembrane transporter activity
PPE_RS04525	COG0561	phosphatase activity
PPE_RS04550	COG2310	stress, protein
PPE_RS04555	COG2310	stress, protein
PPE_RS04560	COG2310	stress, protein
PPE_RS04570	COG0861	Integral membrane protein TerC family
PPE_RS04585	COG1358	cellular component organization or biogenesis
PPE_RS04615	COG2304	oxidoreductase activity
PPE_RS04625	COG4166	transmembrane transport
PPE_RS04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS04635	COG0601	transmembrane transport
PPE_RS04640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PPE_RS04645	COG0765	amino acid transport
PPE_RS04650	COG1126	abc transporter atp-binding protein
PPE_RS04660	COG1309	transcriptional regulator
PPE_RS04725	COG2801	Transposase and inactivated derivatives
PPE_RS04730	COG3401	FG-GAP repeat protein
PPE_RS04740	COG5492	domain, Protein
PPE_RS04740	COG3583	domain protein
PPE_RS04740	COG1621	beta-fructofuranosidase activity
PPE_RS04750	COG1132	(ABC) transporter
PPE_RS04755	COG1132	(ABC) transporter
PPE_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS04790	COG0656	L-ascorbic acid biosynthetic process
PPE_RS04805	COG2814	Major facilitator Superfamily
PPE_RS04810	COG4753	response regulator
PPE_RS04810	COG2207	Transcriptional regulator
PPE_RS04815	COG2972	Histidine kinase
PPE_RS04825	COG1486	melibiose metabolic process
PPE_RS04835	COG5297	Belongs to the glycosyl hydrolase family 6
PPE_RS04845	COG3437	response regulator, receiver
PPE_RS04845	COG2205	protein histidine kinase activity
PPE_RS04845	COG4999	Histidine kinase
PPE_RS04845	COG3850	Histidine kinase
PPE_RS04850	COG1725	Transcriptional regulator
PPE_RS04855	COG1131	(ABC) transporter
PPE_RS04880	COG0656	L-ascorbic acid biosynthetic process
PPE_RS04885	COG3663	DNA glycosylase
PPE_RS04890	COG0686	Belongs to the AlaDH PNT family
PPE_RS04920	COG1253	flavin adenine dinucleotide binding
PPE_RS04925	COG0840	transmembrane signaling receptor activity
PPE_RS04935	COG5522	Integral membrane protein (intg_mem_TP0381)
PPE_RS04940	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS04950	COG1285	pathogenesis
PPE_RS04955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PPE_RS04965	COG2814	Major facilitator Superfamily
PPE_RS04975	COG0697	spore germination
PPE_RS04980	COG1378	Sugar-specific transcriptional regulator TrmB
PPE_RS04990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPE_RS04990	COG1605	Chorismate mutase
PPE_RS05010	COG2205	protein histidine kinase activity
PPE_RS05070	COG2972	Histidine kinase
PPE_RS05080	COG1151	hydroxylamine reductase activity
PPE_RS05115	COG3293	Transposase
PPE_RS05135	COG4213	ABC transporter substrate-binding protein
PPE_RS05145	COG4214	carbohydrate transport
PPE_RS05150	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS05155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PPE_RS05165	COG2217	Heavy metal translocating P-type atpase
PPE_RS05170	COG2223	nitrite transmembrane transporter activity
PPE_RS05195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PPE_RS05205	COG0720	synthase
PPE_RS05210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPE_RS05250	COG1396	sequence-specific DNA binding
PPE_RS05290	COG2823	Periplasmic or secreted lipoprotein
PPE_RS05290	COG1652	LysM domain
PPE_RS05310	COG3299	homolog of phage Mu protein gp47
PPE_RS05335	COG4824	toxin secretion phage lysis holin
PPE_RS05340	COG3757	hydrolase, family 25
PPE_RS05345	COG0747	negative chemotaxis
PPE_RS05350	COG0601	transmembrane transport
PPE_RS05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS05360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PPE_RS05365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS05380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PPE_RS05385	COG3773	Cell wall hydrolase
PPE_RS05390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PPE_RS05395	COG0070	glutamate synthase
PPE_RS05395	COG0067	glutamate synthase
PPE_RS05395	COG0069	glutamate synthase activity
PPE_RS05405	COG2197	response regulator
PPE_RS05410	COG3944	biosynthesis protein
PPE_RS05415	COG0489	protein tyrosine kinase activity
PPE_RS05420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPE_RS05425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPE_RS05430	COG1216	Glycosyl transferase, family 2
PPE_RS05440	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PPE_RS05460	COG0438	transferase activity, transferring glycosyl groups
PPE_RS05465	COG0438	transferase activity, transferring glycosyl groups
PPE_RS05475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PPE_RS05480	COG0662	Cupin 2, conserved barrel domain protein
PPE_RS05480	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPE_RS05485	COG5183	chlorophyll binding
PPE_RS05485	COG2133	pyrroloquinoline quinone binding
PPE_RS05505	COG3944	biosynthesis protein
PPE_RS05510	COG0489	protein tyrosine kinase activity
PPE_RS05515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPE_RS05520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPE_RS05550	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PPE_RS05555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PPE_RS05570	COG1131	(ABC) transporter
PPE_RS05575	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PPE_RS05580	COG0628	permease
PPE_RS05590	COG0739	heme binding
PPE_RS05595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPE_RS05600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS05615	COG0367	asparagine synthase
PPE_RS05640	COG1132	(ABC) transporter
PPE_RS05645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PPE_RS05665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PPE_RS05670	COG4689	acetoacetate decarboxylase
PPE_RS05675	COG0183	Belongs to the thiolase family
PPE_RS05685	COG0802	atpase or kinase
PPE_RS05690	COG1214	PFAM Peptidase M22, glycoprotease
PPE_RS05695	COG0456	acetyltransferase
PPE_RS05700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PPE_RS05705	COG0488	(ABC) transporter
PPE_RS05710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PPE_RS05715	COG0315	cyclic pyranopterin monophosphate synthase activity
PPE_RS05720	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPE_RS05725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPE_RS05730	COG0805	protein transport
PPE_RS05735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PPE_RS05740	COG0459	protein refolding
PPE_RS05785	COG1175	transmembrane transport
PPE_RS05795	COG1653	transport
PPE_RS05800	COG1309	transcriptional regulator
PPE_RS05820	COG0517	IMP dehydrogenase activity
PPE_RS05820	COG4175	Glycine betaine
PPE_RS05825	COG1510	regulation of RNA biosynthetic process
PPE_RS05830	COG2272	Belongs to the type-B carboxylesterase lipase family
PPE_RS05850	COG1131	(ABC) transporter
PPE_RS05855	COG2205	protein histidine kinase activity
PPE_RS05860	COG0745	RESPONSE REGULATOR receiver
PPE_RS05875	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PPE_RS05880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PPE_RS05885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PPE_RS05890	COG0864	Transcriptional regulator
PPE_RS05895	COG2337	Toxic component of a toxin-antitoxin (TA) module
PPE_RS05900	COG2183	response to ionizing radiation
PPE_RS05920	COG0561	phosphatase activity
PPE_RS05925	COG1349	DNA-binding transcription factor activity
PPE_RS05965	COG0830	nickel cation binding
PPE_RS05975	COG0386	Belongs to the glutathione peroxidase family
PPE_RS05985	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PPE_RS06000	COG1914	H( )-stimulated, divalent metal cation uptake system
PPE_RS06010	COG1764	response to oxidative stress
PPE_RS06020	COG3011	Protein conserved in bacteria
PPE_RS06030	COG0803	Belongs to the bacterial solute-binding protein 9 family
PPE_RS06035	COG1121	(ABC) transporter
PPE_RS06040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPE_RS06040	COG1321	iron dependent repressor
PPE_RS06045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPE_RS06050	COG2205	protein histidine kinase activity
PPE_RS06100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PPE_RS06110	COG1090	epimerase
PPE_RS06115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPE_RS06120	COG0788	formyltetrahydrofolate deformylase activity
PPE_RS06140	COG0166	Belongs to the GPI family
PPE_RS06145	COG1739	Uncharacterized protein family UPF0029
PPE_RS06155	COG0432	Pfam Uncharacterised protein family UPF0047
PPE_RS06160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PPE_RS06165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPE_RS06165	COG0321	lipoyl(octanoyl) transferase activity
PPE_RS06170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS06180	COG0561	phosphatase activity
PPE_RS06185	COG0095	Lipoate-protein ligase
PPE_RS06190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPE_RS06195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PPE_RS06200	COG0588	phosphoglycerate mutase activity
PPE_RS06205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPE_RS06210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS06215	COG1120	ATPase activity
PPE_RS06220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PPE_RS06225	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
PPE_RS06230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PPE_RS06235	COG1492	cobalamin metabolic process
PPE_RS06240	COG0840	transmembrane signaling receptor activity
PPE_RS06245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS06245	COG1263	PTS System
PPE_RS06245	COG2190	(PTS) system
PPE_RS06255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PPE_RS06260	COG0006	proline dipeptidase activity
PPE_RS06270	COG1247	-acetyltransferase
PPE_RS06275	COG3610	response to peptide
PPE_RS06280	COG2966	Psort location CytoplasmicMembrane, score
PPE_RS06295	COG2112	serine threonine protein kinase
PPE_RS06305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PPE_RS06320	COG0514	ATP-dependent DNA helicase (RecQ)
PPE_RS06330	COG1785	Belongs to the alkaline phosphatase family
PPE_RS06335	COG0586	Pfam SNARE associated Golgi protein
PPE_RS06390	COG1418	mRNA catabolic process
PPE_RS06440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPE_RS06445	COG2205	protein histidine kinase activity
PPE_RS06450	COG2755	lipolytic protein G-D-S-L family
PPE_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPE_RS06505	COG2814	Major facilitator Superfamily
PPE_RS06510	COG0567	Dehydrogenase, E1 component
PPE_RS06515	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPE_RS06520	COG2318	DinB family
PPE_RS06530	COG1482	cell wall glycoprotein biosynthetic process
PPE_RS06535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PPE_RS06540	COG1242	4 iron, 4 sulfur cluster binding
PPE_RS06550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PPE_RS06555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPE_RS06560	COG0671	phosphoesterase, PA-phosphatase related
PPE_RS06565	COG1215	transferase activity, transferring glycosyl groups
PPE_RS06575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PPE_RS06580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PPE_RS06585	COG1744	ABC transporter substrate-binding protein PnrA-like
PPE_RS06590	COG3845	ABC transporter
PPE_RS06595	COG4603	Belongs to the binding-protein-dependent transport system permease family
PPE_RS06600	COG1079	Belongs to the binding-protein-dependent transport system permease family
PPE_RS06615	COG0028	Belongs to the TPP enzyme family
PPE_RS06620	COG0440	acetolactate synthase activity
PPE_RS06625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PPE_RS06630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPE_RS06640	COG0450	alkyl hydroperoxide reductase
PPE_RS06650	COG5002	protein histidine kinase activity
PPE_RS06680	COG0488	(ABC) transporter
PPE_RS06685	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PPE_RS06695	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PPE_RS06705	COG1193	negative regulation of DNA recombination
PPE_RS06710	COG3766	membrane
PPE_RS06720	COG0477	Major facilitator Superfamily
PPE_RS06740	COG1522	sequence-specific DNA binding
PPE_RS06745	COG0436	Aminotransferase
PPE_RS06760	COG2096	Adenosyltransferase
PPE_RS06765	COG0564	pseudouridine synthase activity
PPE_RS06770	COG1393	Belongs to the ArsC family
PPE_RS06775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPE_RS06780	COG1940	carbohydrate kinase activity
PPE_RS06790	COG0598	Magnesium transport protein CorA
PPE_RS06795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PPE_RS06800	COG0626	cystathionine gamma-synthase activity
PPE_RS06805	COG0626	cystathionine gamma-synthase activity
PPE_RS06810	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPE_RS06815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS06820	COG0475	glutathione-regulated potassium exporter activity
PPE_RS06825	COG0490	domain, Protein
PPE_RS06840	COG3584	3D domain protein
PPE_RS06850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPE_RS06855	COG0745	RESPONSE REGULATOR receiver
PPE_RS06860	COG5002	protein histidine kinase activity
PPE_RS06860	COG3850	Histidine kinase
PPE_RS06865	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PPE_RS06870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPE_RS06875	COG0174	glutamine synthetase
PPE_RS06890	COG2002	toxin-antitoxin pair type II binding
PPE_RS06905	COG2197	response regulator
PPE_RS06910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS06920	COG2766	serine protein kinase
PPE_RS06925	COG3290	protein histidine kinase activity
PPE_RS06925	COG0840	transmembrane signaling receptor activity
PPE_RS06940	COG3212	peptidase
PPE_RS06945	COG4126	flavin adenine dinucleotide binding
PPE_RS06965	COG0745	RESPONSE REGULATOR receiver
PPE_RS06970	COG5002	protein histidine kinase activity
PPE_RS06980	COG2719	SpoVR family
PPE_RS06985	COG2718	Belongs to the UPF0229 family
PPE_RS06990	COG0745	RESPONSE REGULATOR receiver
PPE_RS06995	COG2205	protein histidine kinase activity
PPE_RS07055	COG1609	Transcriptional regulator
PPE_RS07060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PPE_RS07065	COG0561	phosphatase activity
PPE_RS07070	COG3933	PFAM sigma-54 factor interaction domain-containing protein
PPE_RS07070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PPE_RS07075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS07075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS07080	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS07080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS07085	COG3715	PTS system
PPE_RS07090	COG3716	PTS system mannose fructose sorbose family IID component
PPE_RS07100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPE_RS07105	COG1609	Transcriptional regulator
PPE_RS07110	COG4209	transmembrane transport
PPE_RS07115	COG0395	ABC-type sugar transport system, permease component
PPE_RS07125	COG1621	beta-fructofuranosidase activity
PPE_RS07130	COG1396	sequence-specific DNA binding
PPE_RS07135	COG1607	acyl-coa hydrolase
PPE_RS07150	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PPE_RS07160	COG2801	Transposase and inactivated derivatives
PPE_RS07170	COG1307	EDD domain protein, DegV family
PPE_RS07180	COG2363	Small membrane protein
PPE_RS07200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PPE_RS07215	COG0640	Transcriptional regulator
PPE_RS07220	COG2814	Major facilitator Superfamily
PPE_RS07235	COG0456	acetyltransferase
PPE_RS07395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PPE_RS07445	COG0582	viral genome integration into host DNA
PPE_RS07450	COG3377	Domain of unknown function (DUF1805)
PPE_RS07460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PPE_RS07465	COG0783	Belongs to the Dps family
PPE_RS07470	COG0396	ATPase activity
PPE_RS07475	COG0719	Fe-S assembly protein
PPE_RS07480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPE_RS07485	COG0822	iron-sulfur transferase activity
PPE_RS07490	COG0719	Fe-S assembly protein
PPE_RS07500	COG3546	catalase activity
PPE_RS07515	COG0737	Belongs to the 5'-nucleotidase family
PPE_RS07520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPE_RS07520	COG2199	diguanylate cyclase activity
PPE_RS07525	COG0535	radical SAM domain protein
PPE_RS07530	COG1253	flavin adenine dinucleotide binding
PPE_RS07545	COG3546	catalase activity
PPE_RS07550	COG0463	Glycosyl transferase, family 2
PPE_RS07555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPE_RS07565	COG0546	phosphoglycolate phosphatase activity
PPE_RS07570	COG0189	ligase activity
PPE_RS07585	COG0189	ligase activity
PPE_RS07590	COG0189	ligase activity
PPE_RS07595	COG0189	ligase activity
PPE_RS07600	COG3679	Belongs to the UPF0342 family
PPE_RS07610	COG4109	DRTGG domain
PPE_RS07630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPE_RS07640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PPE_RS07645	COG0825	malonyl-CoA metabolic process
PPE_RS07650	COG0469	pyruvate kinase activity
PPE_RS07655	COG0583	DNA-binding transcription factor activity
PPE_RS07660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPE_RS07665	COG0573	inorganic phosphate transmembrane transporter activity
PPE_RS07670	COG0581	inorganic phosphate transmembrane transporter activity
PPE_RS07675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPE_RS07685	COG0824	Thioesterase
PPE_RS07690	COG3030	protein affecting phage T7 exclusion by the F plasmid
PPE_RS07695	COG0628	permease
PPE_RS07700	COG0372	Belongs to the citrate synthase family
PPE_RS07705	COG0538	isocitrate dehydrogenase activity
PPE_RS07710	COG0039	L-malate dehydrogenase activity
PPE_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS07725	COG5002	protein histidine kinase activity
PPE_RS07730	COG0745	RESPONSE REGULATOR receiver
PPE_RS07735	COG0840	transmembrane signaling receptor activity
PPE_RS07740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPE_RS07745	COG0704	Plays a role in the regulation of phosphate uptake
PPE_RS07755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPE_RS07760	COG1971	Probably functions as a manganese efflux pump
PPE_RS07765	COG0237	dephospho-CoA kinase activity
PPE_RS07780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PPE_RS07840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPE_RS07850	COG0583	DNA-binding transcription factor activity
PPE_RS07855	COG4122	O-methyltransferase activity
PPE_RS07860	COG1349	DNA-binding transcription factor activity
PPE_RS07865	COG1105	Belongs to the carbohydrate kinase PfkB family
PPE_RS07870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPE_RS07870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPE_RS07870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS07875	COG0583	DNA-binding transcription factor activity
PPE_RS07880	COG1942	4-Oxalocrotonate Tautomerase
PPE_RS07885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPE_RS07890	COG3711	transcriptional antiterminator
PPE_RS07895	COG2190	(PTS) system
PPE_RS07895	COG1263	PTS System
PPE_RS07895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS07900	COG2723	6-phospho-beta-galactosidase activity
PPE_RS07905	COG0583	DNA-binding transcription factor activity
PPE_RS07910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PPE_RS07915	COG2350	Protein conserved in bacteria
PPE_RS07955	COG0326	Molecular chaperone. Has ATPase activity
PPE_RS08010	COG3279	Response regulator of the LytR AlgR family
PPE_RS08015	COG2972	Histidine kinase
PPE_RS08030	COG4209	transmembrane transport
PPE_RS08035	COG0395	ABC-type sugar transport system, permease component
PPE_RS08040	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS08050	COG5520	Belongs to the glycosyl hydrolase 30 family
PPE_RS08055	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPE_RS08065	COG0371	Dehydrogenase
PPE_RS08085	COG0210	DNA helicase
PPE_RS08090	COG0726	polysaccharide deacetylase
PPE_RS08095	COG4824	toxin secretion phage lysis holin
PPE_RS08105	COG2445	Protein of unknown function DUF86
PPE_RS08115	COG4980	gas vesicle protein
PPE_RS08120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPE_RS08140	COG4844	belongs to the
PPE_RS08150	COG1368	sulfuric ester hydrolase activity
PPE_RS08155	COG0116	Belongs to the methyltransferase superfamily
PPE_RS08160	COG4122	O-methyltransferase activity
PPE_RS08165	COG2814	Major facilitator Superfamily
PPE_RS08170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPE_RS08175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PPE_RS08180	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PPE_RS08185	COG2843	Capsule synthesis protein
PPE_RS08190	COG0584	glycerophosphoryl diester phosphodiesterase
PPE_RS08205	COG1309	transcriptional regulator
PPE_RS08210	COG0488	(ABC) transporter
PPE_RS08215	COG1363	Peptidase, m42
PPE_RS08220	COG5416	Lipopolysaccharide assembly protein A domain
PPE_RS08225	COG1164	Oligoendopeptidase f
PPE_RS08240	COG0534	Mate efflux family protein
PPE_RS08260	COG0534	Mate efflux family protein
PPE_RS08275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS08280	COG0513	Belongs to the DEAD box helicase family
PPE_RS08285	COG5578	integral membrane protein
PPE_RS08300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PPE_RS08305	COG0705	Rhomboid family
PPE_RS08310	COG0583	DNA-binding transcription factor activity
PPE_RS08315	COG2738	Putative neutral zinc metallopeptidase
PPE_RS08320	COG0789	Transcriptional regulator
PPE_RS08325	COG0004	ammonium transporteR
PPE_RS08335	COG2176	DNA-directed DNA polymerase activity
PPE_RS08345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPE_RS08350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPE_RS08355	COG1141	Ferredoxin
PPE_RS08365	COG0167	dihydroorotate dehydrogenase activity
PPE_RS08370	COG2357	RelA SpoT domain protein
PPE_RS08375	COG1547	Domain of unknown function (DUF309)
PPE_RS08385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPE_RS08385	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PPE_RS08390	COG1187	pseudouridine synthase activity
PPE_RS08395	COG5002	protein histidine kinase activity
PPE_RS08395	COG5001	Diguanylate cyclase
PPE_RS08395	COG3447	MASE1 domain protein
PPE_RS08405	COG3949	Membrane
PPE_RS08410	COG0586	Pfam SNARE associated Golgi protein
PPE_RS08415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPE_RS08430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPE_RS08445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPE_RS08450	COG2861	carbohydrate metabolic process
PPE_RS08475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPE_RS08485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPE_RS08495	COG2378	regulation of single-species biofilm formation
PPE_RS08505	COG2814	Major facilitator Superfamily
PPE_RS08510	COG1309	transcriptional regulator
PPE_RS08525	COG0456	acetyltransferase
PPE_RS08525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PPE_RS08530	COG0436	Aminotransferase
PPE_RS08560	COG0395	ABC-type sugar transport system, permease component
PPE_RS08565	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS08570	COG3940	Belongs to the glycosyl hydrolase 43 family
PPE_RS08580	COG2226	methyltransferase
PPE_RS08585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PPE_RS08585	COG0456	acetyltransferase
PPE_RS08600	COG1846	Transcriptional regulator
PPE_RS08610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPE_RS08615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPE_RS08655	COG1609	Transcriptional regulator
PPE_RS08675	COG4895	conserved protein (DUF2196)
PPE_RS08680	COG3647	Membrane
PPE_RS08685	COG0438	transferase activity, transferring glycosyl groups
PPE_RS08695	COG4129	membrane
PPE_RS08700	COG3973	AAA domain
PPE_RS08705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PPE_RS08720	COG0840	transmembrane signaling receptor activity
PPE_RS08725	COG2211	Major facilitator Superfamily
PPE_RS08730	COG1114	Component of the transport system for branched-chain amino acids
PPE_RS08735	COG2207	Transcriptional regulator
PPE_RS08735	COG1917	Cupin 2, conserved barrel domain protein
PPE_RS08740	COG1501	Belongs to the glycosyl hydrolase 31 family
PPE_RS08755	COG2814	Major facilitator Superfamily
PPE_RS08760	COG2814	Major facilitator Superfamily
PPE_RS08765	COG1846	Transcriptional regulator
PPE_RS08770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PPE_RS08775	COG0517	IMP dehydrogenase activity
PPE_RS08785	COG1649	PFAM Uncharacterised BCR, COG1649
PPE_RS08785	COG0726	polysaccharide deacetylase
PPE_RS08805	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PPE_RS08815	COG1846	Transcriptional regulator
PPE_RS08820	COG5012	cobalamin binding
PPE_RS08825	COG2205	protein histidine kinase activity
PPE_RS08825	COG2198	Histidine kinase
PPE_RS08825	COG0784	Response regulator, receiver
PPE_RS08830	COG2211	Major facilitator Superfamily
PPE_RS08845	COG2755	lipolytic protein G-D-S-L family
PPE_RS08855	COG5646	InterPro IPR014922
PPE_RS08870	COG1454	alcohol dehydrogenase
PPE_RS08885	COG1846	Transcriptional regulator
PPE_RS08890	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS08920	COG2207	Transcriptional regulator
PPE_RS08925	COG0531	amino acid
PPE_RS08945	COG0742	ribosomal rna small subunit methyltransferase
PPE_RS08950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PPE_RS08955	COG3314	Sporulation integral membrane protein YlbJ
PPE_RS08960	COG3480	Lon protease (S16) C-terminal proteolytic domain
PPE_RS08990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPE_RS09000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPE_RS09005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPE_RS09010	COG0571	ribonuclease III activity
PPE_RS09015	COG1196	nuclear chromosome segregation
PPE_RS09020	COG0552	protein localization to endoplasmic reticulum
PPE_RS09025	COG1272	protein, Hemolysin III
PPE_RS09030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PPE_RS09035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PPE_RS09040	COG0228	four-way junction DNA binding
PPE_RS09050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PPE_RS09055	COG0336	Belongs to the RNA methyltransferase TrmD family
PPE_RS09060	COG0335	large ribosomal subunit rRNA binding
PPE_RS09075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PPE_RS09090	COG0792	nuclease activity
PPE_RS09105	COG1764	response to oxidative stress
PPE_RS09110	COG1846	Transcriptional regulator
PPE_RS09115	COG0045	succinate-CoA ligase (ADP-forming) activity
PPE_RS09120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PPE_RS09125	COG0758	DNA mediated transformation
PPE_RS09130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPE_RS09135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PPE_RS09140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PPE_RS09145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PPE_RS09150	COG1815	bacterial-type flagellum-dependent cell motility
PPE_RS09155	COG1558	bacterial-type flagellum-dependent cell motility
PPE_RS09160	COG1677	Flagellar hook-basal body complex protein FliE
PPE_RS09165	COG1766	The M ring may be actively involved in energy transduction
PPE_RS09170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPE_RS09180	COG1157	protein secretion by the type III secretion system
PPE_RS09185	COG2882	bacterial-type flagellum organization
PPE_RS09200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PPE_RS09210	COG4786	Flagellar basal body rod
PPE_RS09225	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPE_RS09230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPE_RS09230	COG1776	CheC inhibitor of MCP methylation
PPE_RS09235	COG2201	protein-glutamate methylesterase activity
PPE_RS09240	COG3190	flagellar
PPE_RS09245	COG1338	Plays a role in the flagellum-specific transport system
PPE_RS09250	COG1987	bacterial-type flagellum assembly
PPE_RS09255	COG1684	flagellar biosynthetic protein fliR
PPE_RS09260	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPE_RS09265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPE_RS09270	COG1419	protein localization to endoplasmic reticulum
PPE_RS09275	COG0455	bacterial-type flagellum organization
PPE_RS09280	COG2201	protein-glutamate methylesterase activity
PPE_RS09285	COG0643	Histidine kinase
PPE_RS09285	COG2198	Histidine kinase
PPE_RS09295	COG1776	CheC inhibitor of MCP methylation
PPE_RS09300	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PPE_RS09310	COG1191	sigma factor activity
PPE_RS09335	COG0052	Belongs to the universal ribosomal protein uS2 family
PPE_RS09340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PPE_RS09345	COG0528	UMP kinase activity
PPE_RS09350	COG0233	cytoplasmic translational termination
PPE_RS09355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PPE_RS09360	COG4589	Belongs to the CDS family
PPE_RS09365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PPE_RS09370	COG0750	zinc metalloprotease
PPE_RS09375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPE_RS09380	COG2176	DNA-directed DNA polymerase activity
PPE_RS09385	COG0779	Required for maturation of 30S ribosomal subunits
PPE_RS09390	COG0195	Participates in both transcription termination and antitermination
PPE_RS09400	COG1358	cellular component organization or biogenesis
PPE_RS09410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PPE_RS09415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PPE_RS09420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PPE_RS09425	COG0196	riboflavin kinase activity
PPE_RS09430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PPE_RS09435	COG1185	polyribonucleotide nucleotidyltransferase activity
PPE_RS09440	COG0726	polysaccharide deacetylase
PPE_RS09445	COG0612	Peptidase, M16
PPE_RS09450	COG0756	dUTP diphosphatase activity
PPE_RS09455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPE_RS09460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPE_RS09465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PPE_RS09470	COG0527	aspartate kinase activity
PPE_RS09475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPE_RS09480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PPE_RS09485	COG0740	serine-type endopeptidase activity
PPE_RS09495	COG1674	ftsk spoiiie
PPE_RS09505	COG0612	Peptidase, M16
PPE_RS09510	COG0612	Peptidase, M16
PPE_RS09515	COG0300	oxidoreductase activity
PPE_RS09530	COG1426	Protein conserved in bacteria
PPE_RS09540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPE_RS09545	COG1546	Belongs to the CinA family
PPE_RS09545	COG1058	Belongs to the CinA family
PPE_RS09565	COG1692	metallophosphoesterase
PPE_RS09570	COG2359	stage V sporulation protein S
PPE_RS09585	COG4869	propanediol catabolic process
PPE_RS09590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPE_RS09595	COG4550	Control of competence regulator ComK, YlbF/YmcA
PPE_RS09610	COG1335	isochorismatase
PPE_RS09615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PPE_RS09620	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPE_RS09630	COG0018	arginyl-trna synthetase
PPE_RS09640	COG1132	(ABC) transporter
PPE_RS09645	COG1132	(ABC) transporter
PPE_RS09660	COG2707	UPF0756 membrane protein
PPE_RS09665	COG0492	ferredoxin-NADP+ reductase activity
PPE_RS09670	COG0640	Transcriptional regulator
PPE_RS09680	COG1376	ErfK ybiS ycfS ynhG family protein
PPE_RS09695	COG1674	ftsk spoiiie
PPE_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS09735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS09785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPE_RS09790	COG1643	Atp-dependent helicase
PPE_RS09815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PPE_RS09820	COG3599	regulation of cell shape
PPE_RS09825	COG1959	2 iron, 2 sulfur cluster binding
PPE_RS09860	COG1733	regulation of RNA biosynthetic process
PPE_RS09865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPE_RS09870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PPE_RS09875	COG2135	peptidase activity
PPE_RS09880	COG0477	Major facilitator Superfamily
PPE_RS09885	COG1764	response to oxidative stress
PPE_RS09890	COG2706	6-phosphogluconolactonase activity
PPE_RS09905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPE_RS09935	COG0534	Mate efflux family protein
PPE_RS09940	COG1404	Belongs to the peptidase S8 family
PPE_RS09950	COG3527	Alpha-acetolactate decarboxylase
PPE_RS09955	COG0028	Belongs to the TPP enzyme family
PPE_RS09960	COG1904	glucuronate isomerase
PPE_RS09965	COG2211	Major facilitator Superfamily
PPE_RS09970	COG1609	Transcriptional regulator
PPE_RS09975	COG0028	Belongs to the TPP enzyme family
PPE_RS09980	COG0246	Mannitol dehydrogenase
PPE_RS09985	COG2721	sulfolactate sulfo-lyase activity
PPE_RS10000	COG4209	transmembrane transport
PPE_RS10005	COG0395	ABC-type sugar transport system, permease component
PPE_RS10020	COG4753	response regulator
PPE_RS10020	COG2207	Transcriptional regulator
PPE_RS10030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPE_RS10035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPE_RS10040	COG0058	SHG alpha-glucan phosphorylase activity
PPE_RS10060	COG0667	Aldo Keto reductase
PPE_RS10065	COG0523	cobalamin synthesis protein
PPE_RS10070	COG0583	DNA-binding transcription factor activity
PPE_RS10075	COG2329	Antibiotic biosynthesis monooxygenase
PPE_RS10080	COG5002	protein histidine kinase activity
PPE_RS10085	COG2323	membrane
PPE_RS10090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PPE_RS10095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS10100	COG0431	NADPH-dependent FMN reductase
PPE_RS10105	COG0583	DNA-binding transcription factor activity
PPE_RS10110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS10115	COG0765	amino acid transport
PPE_RS10120	COG0765	amino acid transport
PPE_RS10125	COG1126	abc transporter atp-binding protein
PPE_RS10130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS10135	COG1473	amidohydrolase
PPE_RS10150	COG0747	negative chemotaxis
PPE_RS10155	COG0601	transmembrane transport
PPE_RS10160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS10165	COG0444	Belongs to the ABC transporter superfamily
PPE_RS10170	COG4608	Belongs to the ABC transporter superfamily
PPE_RS10190	COG5002	protein histidine kinase activity
PPE_RS10195	COG2132	Multicopper oxidase
PPE_RS10210	COG0745	RESPONSE REGULATOR receiver
PPE_RS10240	COG1714	RDD family
PPE_RS10245	COG1199	ATP-dependent helicase activity
PPE_RS10260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPE_RS10265	COG0626	cystathionine gamma-synthase activity
PPE_RS10330	COG0477	Major facilitator Superfamily
PPE_RS10345	COG0254	rRNA binding
PPE_RS10350	COG0523	cobalamin synthesis protein
PPE_RS10360	COG0701	Predicted permease
PPE_RS10365	COG0523	cobalamin synthesis protein
PPE_RS10370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS10375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPE_RS10380	COG1121	(ABC) transporter
PPE_RS10385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPE_RS10390	COG0803	Belongs to the bacterial solute-binding protein 9 family
PPE_RS10395	COG2201	protein-glutamate methylesterase activity
PPE_RS10405	COG0346	lactoylglutathione lyase activity
PPE_RS10435	COG5002	protein histidine kinase activity
PPE_RS10435	COG3850	Histidine kinase
PPE_RS10450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PPE_RS10460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PPE_RS10465	COG1959	2 iron, 2 sulfur cluster binding
PPE_RS10470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS10475	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS10475	COG3347	Dehydrogenase
PPE_RS10480	COG4952	isomerase
PPE_RS10485	COG1070	Carbohydrate kinase
PPE_RS10490	COG1349	DNA-binding transcription factor activity
PPE_RS10495	COG0247	lactate metabolic process
PPE_RS10500	COG1139	Iron-sulfur cluster binding protein
PPE_RS10530	COG2755	lipolytic protein G-D-S-L family
PPE_RS10530	COG3401	FG-GAP repeat protein
PPE_RS10555	COG1136	(ABC) transporter
PPE_RS10560	COG1136	(ABC) transporter
PPE_RS10560	COG0577	efflux transmembrane transporter activity
PPE_RS10565	COG0517	IMP dehydrogenase activity
PPE_RS10570	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PPE_RS10575	COG1494	fructose-1,6-bisphosphatase
PPE_RS10585	COG3293	Transposase
PPE_RS10610	COG1132	(ABC) transporter
PPE_RS10615	COG1132	(ABC) transporter
PPE_RS10645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPE_RS10650	COG1827	regulation of RNA biosynthetic process
PPE_RS10655	COG1104	cysteine desulfurase activity
PPE_RS10660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PPE_RS10680	COG0671	phosphoesterase, PA-phosphatase related
PPE_RS10690	COG0745	RESPONSE REGULATOR receiver
PPE_RS10695	COG5002	protein histidine kinase activity
PPE_RS10695	COG3850	Histidine kinase
PPE_RS10700	COG0791	NLP P60 protein
PPE_RS10705	COG0438	transferase activity, transferring glycosyl groups
PPE_RS10725	COG0189	ligase activity
PPE_RS10735	COG2323	membrane
PPE_RS10740	COG1119	ATPase activity
PPE_RS10745	COG3874	Sporulation protein YtfJ
PPE_RS10750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PPE_RS10765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPE_RS10785	COG1054	Belongs to the UPF0176 family
PPE_RS10795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPE_RS10800	COG0563	adenylate kinase activity
PPE_RS10805	COG0442	prolyl-tRNA aminoacylation
PPE_RS10815	COG3511	phospholipase C
PPE_RS10820	COG0745	RESPONSE REGULATOR receiver
PPE_RS10825	COG5002	protein histidine kinase activity
PPE_RS10860	COG2140	Oxalate decarboxylase
PPE_RS10865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PPE_RS10870	COG0222	ribosome binding
PPE_RS10875	COG1802	Transcriptional regulator
PPE_RS10905	COG0622	Phosphoesterase
PPE_RS10915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPE_RS10945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS10950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS10955	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS10960	COG1733	regulation of RNA biosynthetic process
PPE_RS10975	COG1187	pseudouridine synthase activity
PPE_RS10995	COG0697	spore germination
PPE_RS11010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPE_RS11025	COG4978	Transcriptional regulator
PPE_RS11025	COG0789	Transcriptional regulator
PPE_RS11030	COG0789	Transcriptional regulator
PPE_RS11030	COG4978	Transcriptional regulator
PPE_RS11075	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS11080	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS11085	COG2267	carboxylic ester hydrolase activity
PPE_RS11115	COG0740	serine-type endopeptidase activity
PPE_RS11135	COG0024	Methionine aminopeptidase
PPE_RS11145	COG5566	PFAM Mor transcription activator
PPE_RS11155	COG1331	Highly conserved protein containing a thioredoxin domain
PPE_RS11160	COG0840	transmembrane signaling receptor activity
PPE_RS11170	COG0745	RESPONSE REGULATOR receiver
PPE_RS11180	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS11185	COG2203	Gaf domain
PPE_RS11185	COG2199	diguanylate cyclase activity
PPE_RS11190	COG3459	Glycosyltransferase 36 associated
PPE_RS11195	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PPE_RS11205	COG2363	Small membrane protein
PPE_RS11210	COG4447	cellulose binding
PPE_RS11210	COG5297	Belongs to the glycosyl hydrolase family 6
PPE_RS11215	COG1528	Iron-storage protein
PPE_RS11220	COG0456	acetyltransferase
PPE_RS11225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS11230	COG4946	Tricorn protease homolog
PPE_RS11230	COG0823	Involved in the tonB-independent uptake of proteins
PPE_RS11230	COG1506	peptidase
PPE_RS11235	COG4335	DNA alkylation repair
PPE_RS11240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPE_RS11270	COG0425	Belongs to the sulfur carrier protein TusA family
PPE_RS11270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPE_RS11275	COG2210	Belongs to the sulfur carrier protein TusA family
PPE_RS11280	COG1937	Protein conserved in bacteria
PPE_RS11285	COG2323	membrane
PPE_RS11310	COG0596	Alpha beta hydrolase
PPE_RS11315	COG3293	Transposase
PPE_RS11325	COG0596	Alpha beta hydrolase
PPE_RS11330	COG1011	Hydrolase
PPE_RS11345	COG1609	Transcriptional regulator
PPE_RS11350	COG2972	Histidine kinase
PPE_RS11355	COG2207	Transcriptional regulator
PPE_RS11370	COG0395	ABC-type sugar transport system, permease component
PPE_RS11375	COG0745	RESPONSE REGULATOR receiver
PPE_RS11380	COG2205	protein histidine kinase activity
PPE_RS11385	COG1136	(ABC) transporter
PPE_RS11390	COG0577	efflux transmembrane transporter activity
PPE_RS11400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPE_RS11400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PPE_RS11405	COG1136	(ABC) transporter
PPE_RS11410	COG0577	efflux transmembrane transporter activity
PPE_RS11410	COG1136	(ABC) transporter
PPE_RS11420	COG1595	DNA-templated transcription, initiation
PPE_RS11430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPE_RS11435	COG1063	alcohol dehydrogenase
PPE_RS11440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PPE_RS11450	COG2207	Transcriptional regulator
PPE_RS11455	COG0673	inositol 2-dehydrogenase activity
PPE_RS11460	COG1874	Beta-galactosidase
PPE_RS11460	COG0366	Alpha amylase catalytic
PPE_RS11495	COG0477	Major facilitator Superfamily
PPE_RS11500	COG0583	DNA-binding transcription factor activity
PPE_RS11515	COG1733	regulation of RNA biosynthetic process
PPE_RS11525	COG4124	Belongs to the glycosyl hydrolase 26 family
PPE_RS11530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPE_RS11540	COG1902	pentaerythritol trinitrate reductase activity
PPE_RS11570	COG1846	Transcriptional regulator
PPE_RS11575	COG0456	acetyltransferase
PPE_RS11580	COG0596	Alpha beta hydrolase
PPE_RS11590	COG3275	phosphorelay sensor kinase activity
PPE_RS11595	COG4753	response regulator
PPE_RS11595	COG2207	Transcriptional regulator
PPE_RS11610	COG4209	transmembrane transport
PPE_RS11615	COG0395	ABC-type sugar transport system, permease component
PPE_RS11640	COG0697	spore germination
PPE_RS11665	COG0300	oxidoreductase activity
PPE_RS11670	COG1063	alcohol dehydrogenase
PPE_RS11705	COG2367	Beta-lactamase
PPE_RS11720	COG1312	Catalyzes the dehydration of D-mannonate
PPE_RS11725	COG0246	Mannitol dehydrogenase
PPE_RS11740	COG0667	Aldo Keto reductase
PPE_RS11745	COG0673	inositol 2-dehydrogenase activity
PPE_RS11755	COG0673	inositol 2-dehydrogenase activity
PPE_RS11760	COG1609	Transcriptional regulator
PPE_RS11775	COG0673	inositol 2-dehydrogenase activity
PPE_RS11785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPE_RS11795	COG2814	Major facilitator Superfamily
PPE_RS11805	COG1309	transcriptional regulator
PPE_RS11810	COG0477	Major facilitator Superfamily
PPE_RS11820	COG0601	transmembrane transport
PPE_RS11825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS11835	COG0534	Mate efflux family protein
PPE_RS11840	COG0753	catalase activity
PPE_RS11845	COG0529	Catalyzes the synthesis of activated sulfate
PPE_RS11880	COG2514	catechol 2,3-dioxygenase activity
PPE_RS11885	COG2259	Doxx family
PPE_RS11900	COG5434	Belongs to the glycosyl hydrolase 28 family
PPE_RS11900	COG4632	Exopolysaccharide biosynthesis protein
PPE_RS11915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPE_RS11920	COG2186	Transcriptional regulator
PPE_RS11925	COG2017	converts alpha-aldose to the beta-anomer
PPE_RS11930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPE_RS11940	COG2309	aminopeptidase activity
PPE_RS11955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPE_RS11960	COG1253	flavin adenine dinucleotide binding
PPE_RS11970	COG3773	Cell wall hydrolase
PPE_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS11995	COG0531	amino acid
PPE_RS12000	COG0039	L-malate dehydrogenase activity
PPE_RS12020	COG2801	Transposase and inactivated derivatives
PPE_RS12025	COG1193	negative regulation of DNA recombination
PPE_RS12035	COG4974	Belongs to the 'phage' integrase family
PPE_RS12045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS12050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS12055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPE_RS12060	COG1132	(ABC) transporter
PPE_RS12065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPE_RS12070	COG1879	ABC-type sugar transport system periplasmic component
PPE_RS12075	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPE_RS12080	COG1129	ABC transporter
PPE_RS12090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPE_RS12095	COG1609	Transcriptional regulator
PPE_RS12100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PPE_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS12140	COG4974	Belongs to the 'phage' integrase family
PPE_RS12145	COG1763	Mo-molybdopterin cofactor biosynthetic process
PPE_RS12150	COG0303	'Molybdopterin
PPE_RS12180	COG1842	Phage shock protein A
PPE_RS12185	COG1902	pentaerythritol trinitrate reductase activity
PPE_RS12195	COG1388	LysM domain
PPE_RS12195	COG3584	3D domain protein
PPE_RS12200	COG1126	abc transporter atp-binding protein
PPE_RS12205	COG0765	amino acid transport
PPE_RS12210	COG1473	amidohydrolase
PPE_RS12220	COG0297	glycogen (starch) synthase activity
PPE_RS12225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PPE_RS12230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPE_RS12235	COG5002	protein histidine kinase activity
PPE_RS12240	COG0745	RESPONSE REGULATOR receiver
PPE_RS12255	COG0477	Major facilitator Superfamily
PPE_RS12275	COG0493	'glutamate synthase
PPE_RS12280	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PPE_RS12285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PPE_RS12300	COG0022	dehydrogenase e1 component
PPE_RS12315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPE_RS12320	COG1564	THIamine pyrophosphokinase
PPE_RS12325	COG0791	NLP P60 protein
PPE_RS12330	COG0745	RESPONSE REGULATOR receiver
PPE_RS12335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPE_RS12340	COG2022	thiamine diphosphate biosynthetic process
PPE_RS12350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPE_RS12355	COG0352	thiamine-phosphate diphosphorylase activity
PPE_RS12360	COG0488	(ABC) transporter
PPE_RS12415	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PPE_RS12420	COG1119	ATPase activity
PPE_RS12425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPE_RS12430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPE_RS12435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPE_RS12450	COG1234	tRNA 3'-trailer cleavage
PPE_RS12455	COG1410	methionine synthase
PPE_RS12455	COG0646	methionine synthase
PPE_RS12460	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PPE_RS12465	COG1011	Hydrolase
PPE_RS12475	COG4224	UPF0291 protein
PPE_RS12485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPE_RS12510	COG2801	Transposase and inactivated derivatives
PPE_RS12535	COG2801	Transposase and inactivated derivatives
PPE_RS12550	COG2801	Transposase and inactivated derivatives
PPE_RS12575	COG1959	2 iron, 2 sulfur cluster binding
PPE_RS12615	COG0174	glutamine synthetase
PPE_RS12620	COG0789	Transcriptional regulator
PPE_RS12625	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PPE_RS12630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PPE_RS12635	COG0464	growth
PPE_RS12650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPE_RS12655	COG1923	regulation of RNA biosynthetic process
PPE_RS12660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPE_RS12665	COG2521	methyltransferase
PPE_RS12665	COG2136	Putative SAM-dependent methyltransferase
PPE_RS12670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PPE_RS12675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PPE_RS12690	COG0583	DNA-binding transcription factor activity
PPE_RS12695	COG0531	amino acid
PPE_RS12700	COG4129	membrane
PPE_RS12705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPE_RS12710	COG1116	anion transmembrane transporter activity
PPE_RS12715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPE_RS12720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PPE_RS12725	COG0288	reversible hydration of carbon dioxide
PPE_RS12750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPE_RS12755	COG3119	arylsulfatase activity
PPE_RS12770	COG1566	PFAM secretion protein HlyD family protein
PPE_RS12775	COG2814	Major facilitator Superfamily
PPE_RS12780	COG1566	PFAM secretion protein HlyD family protein
PPE_RS12790	COG0716	FMN binding
PPE_RS12800	COG0564	pseudouridine synthase activity
PPE_RS12805	COG2814	Major facilitator Superfamily
PPE_RS12810	COG1846	Transcriptional regulator
PPE_RS12820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PPE_RS12835	COG1131	(ABC) transporter
PPE_RS12850	COG2340	Cysteine-rich secretory protein family
PPE_RS12860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PPE_RS12865	COG1132	(ABC) transporter
PPE_RS12870	COG1132	(ABC) transporter
PPE_RS12875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PPE_RS12885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PPE_RS12895	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPE_RS12900	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPE_RS12905	COG0066	3-isopropylmalate dehydratase activity
PPE_RS12910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPE_RS12915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PPE_RS12965	COG3383	formate dehydrogenase (NAD+) activity
PPE_RS12970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPE_RS12980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPE_RS12980	COG0493	'glutamate synthase
PPE_RS12985	COG1027	Aspartate ammonia-lyase
PPE_RS13000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPE_RS13010	COG0583	DNA-binding transcription factor activity
PPE_RS13030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPE_RS13035	COG0436	Aminotransferase
PPE_RS13040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PPE_RS13045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PPE_RS13055	COG1850	ribulose-bisphosphate carboxylase activity
PPE_RS13060	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PPE_RS13065	COG0235	Class ii aldolase
PPE_RS13070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PPE_RS13095	COG3935	DnaD domain protein
PPE_RS13100	COG0017	Asparaginyl-tRNA synthetase
PPE_RS13105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PPE_RS13110	COG1250	3-hydroxyacyl-CoA dehydrogenase
PPE_RS13115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPE_RS13135	COG2112	serine threonine protein kinase
PPE_RS13145	COG0402	S-adenosylhomocysteine deaminase activity
PPE_RS13150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PPE_RS13155	COG1199	ATP-dependent helicase activity
PPE_RS13155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPE_RS13165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PPE_RS13170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PPE_RS13175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PPE_RS13185	COG0617	tRNA 3'-terminal CCA addition
PPE_RS13190	COG0438	transferase activity, transferring glycosyl groups
PPE_RS13195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PPE_RS13200	COG1803	Methylglyoxal synthase
PPE_RS13205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPE_RS13215	COG1694	Mazg nucleotide pyrophosphohydrolase
PPE_RS13220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS13235	COG4347	Protein of unknown function (DUF1405)
PPE_RS13255	COG0588	phosphoglycerate mutase activity
PPE_RS13275	COG0287	Prephenate dehydrogenase
PPE_RS13280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPE_RS13285	COG0159	tryptophan synthase activity
PPE_RS13290	COG0133	tryptophan synthase activity
PPE_RS13295	COG0135	phosphoribosylanthranilate isomerase activity
PPE_RS13300	COG0134	indole-3-glycerol-phosphate synthase activity
PPE_RS13305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPE_RS13315	COG4401	Chorismate mutase type I
PPE_RS13320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPE_RS13325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PPE_RS13330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPE_RS13335	COG0105	UTP biosynthetic process
PPE_RS13345	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPE_RS13350	COG0163	prenyltransferase activity
PPE_RS13355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPE_RS13360	COG2226	methyltransferase
PPE_RS13385	COG0776	regulation of translation
PPE_RS13390	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPE_RS13395	COG1129	ABC transporter
PPE_RS13410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PPE_RS13415	COG2871	sodium ion transport
PPE_RS13430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PPE_RS13435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PPE_RS13440	COG1160	GTP binding
PPE_RS13455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PPE_RS13460	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PPE_RS13465	COG2959	enzyme of heme biosynthesis
PPE_RS13470	COG2339	peptidase activity
PPE_RS13475	COG4862	establishment of competence for transformation
PPE_RS13500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPE_RS13505	COG5002	protein histidine kinase activity
PPE_RS13510	COG0745	RESPONSE REGULATOR receiver
PPE_RS13515	COG1187	pseudouridine synthase activity
PPE_RS13520	COG0700	Nucleoside recognition
PPE_RS13525	COG2715	membrane protein required for spore maturation
PPE_RS13530	COG1686	Belongs to the peptidase S11 family
PPE_RS13540	COG3874	Sporulation protein YtfJ
PPE_RS13550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PPE_RS13555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PPE_RS13565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPE_RS13565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPE_RS13580	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPE_RS13590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PPE_RS13595	COG0019	diaminopimelate decarboxylase activity
PPE_RS13600	COG0697	spore germination
PPE_RS13620	COG2172	sigma factor antagonist activity
PPE_RS13625	COG1366	Belongs to the anti-sigma-factor antagonist family
PPE_RS13630	COG1686	Belongs to the peptidase S11 family
PPE_RS13650	COG4974	Belongs to the 'phage' integrase family
PPE_RS13660	COG0735	belongs to the Fur family
PPE_RS13665	COG1300	Membrane
PPE_RS13670	COG1379	DNA repair
PPE_RS13675	COG0494	nUDIX hydrolase
PPE_RS13680	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPE_RS13685	COG0321	lipoyl(octanoyl) transferase activity
PPE_RS13690	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPE_RS13695	COG0022	dehydrogenase e1 component
PPE_RS13700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPE_RS13705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPE_RS13715	COG1435	thymidine kinase activity
PPE_RS13720	COG4326	sporulation control protein
PPE_RS13730	COG0840	transmembrane signaling receptor activity
PPE_RS13740	COG0745	RESPONSE REGULATOR receiver
PPE_RS13745	COG0750	zinc metalloprotease
PPE_RS13750	COG0497	DNA recombination
PPE_RS13755	COG1438	arginine binding
PPE_RS13765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PPE_RS13770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPE_RS13775	COG0142	geranyltranstransferase activity
PPE_RS13780	COG1722	exodeoxyribonuclease VII activity
PPE_RS13790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPE_RS13795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPE_RS13810	COG1302	Protein conserved in bacteria
PPE_RS13815	COG0439	Biotin carboxylase
PPE_RS13820	COG0511	ligase activity, forming carbon-carbon bonds
PPE_RS13860	COG3854	ATPases associated with a variety of cellular activities
PPE_RS13870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPE_RS13875	COG0006	proline dipeptidase activity
PPE_RS13890	COG3872	metal-dependent enzyme
PPE_RS13900	COG1752	Esterase of the alpha-beta hydrolase superfamily
PPE_RS13905	COG1649	PFAM Uncharacterised BCR, COG1649
PPE_RS13910	COG1321	iron dependent repressor
PPE_RS13915	COG1533	DNA photolyase activity
PPE_RS13920	COG0785	Cytochrome C biogenesis protein
PPE_RS13925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPE_RS13925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPE_RS13930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PPE_RS13935	COG0735	belongs to the Fur family
PPE_RS13945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PPE_RS13950	COG1882	Formate acetyltransferase
PPE_RS13955	COG1012	belongs to the aldehyde dehydrogenase family
PPE_RS13955	COG1454	alcohol dehydrogenase
PPE_RS13960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPE_RS13965	COG3384	dioxygenase
PPE_RS13970	COG1733	regulation of RNA biosynthetic process
PPE_RS13985	COG0673	inositol 2-dehydrogenase activity
PPE_RS13995	COG0673	inositol 2-dehydrogenase activity
PPE_RS14005	COG3534	alpha-L-arabinofuranosidase
PPE_RS14020	COG0673	inositol 2-dehydrogenase activity
PPE_RS14025	COG0861	Integral membrane protein TerC family
PPE_RS14030	COG0398	Pfam SNARE associated Golgi protein
PPE_RS14035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPE_RS14035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPE_RS14045	COG4876	unkown
PPE_RS14050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS14070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPE_RS14075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPE_RS14085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PPE_RS14090	COG1307	EDD domain protein, DegV family
PPE_RS14095	COG1461	Dihydroxyacetone kinase
PPE_RS14100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PPE_RS14110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPE_RS14115	COG1162	GTPase activity
PPE_RS14120	COG2815	serine threonine protein kinase
PPE_RS14120	COG0515	serine threonine protein kinase
PPE_RS14125	COG0631	protein serine/threonine phosphatase activity
PPE_RS14130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPE_RS14135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPE_RS14135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPE_RS14140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PPE_RS14145	COG0242	peptide deformylase activity
PPE_RS14150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPE_RS14155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPE_RS14160	COG1758	RNA polymerase activity
PPE_RS14165	COG0194	GDP metabolic process
PPE_RS14170	COG2052	Domain of unknown function (DUF370)
PPE_RS14175	COG1561	YicC-like family, N-terminal region
PPE_RS14180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPE_RS14180	COG0646	methionine synthase
PPE_RS14195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PPE_RS14200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPE_RS14210	COG0613	PHP domain protein
PPE_RS14225	COG4471	UPF0298 protein
PPE_RS14245	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PPE_RS14250	COG1473	amidohydrolase
PPE_RS14255	COG0772	Belongs to the SEDS family
PPE_RS14260	COG1302	Protein conserved in bacteria
PPE_RS14265	COG0387	Pfam Sodium calcium exchanger
PPE_RS14270	COG4838	Belongs to the UPF0358 family
PPE_RS14280	COG2309	aminopeptidase activity
PPE_RS14290	COG2203	Gaf domain
PPE_RS14290	COG2199	diguanylate cyclase activity
PPE_RS14295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PPE_RS14300	COG3708	Transcriptional regulator
PPE_RS14300	COG2207	Transcriptional regulator
PPE_RS14305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PPE_RS14315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPE_RS14320	COG0454	-acetyltransferase
PPE_RS14325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPE_RS14330	COG1609	Transcriptional regulator
PPE_RS14345	COG0693	protein deglycase activity
PPE_RS14350	COG2801	Transposase and inactivated derivatives
PPE_RS14360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPE_RS14365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS14365	COG1263	PTS System
PPE_RS14365	COG2190	(PTS) system
PPE_RS14370	COG1832	CoA-binding protein
PPE_RS14375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PPE_RS14380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPE_RS14385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PPE_RS14400	COG4493	Belongs to the UPF0637 family
PPE_RS14410	COG1982	Orn Lys Arg decarboxylase major
PPE_RS14425	COG1234	tRNA 3'-trailer cleavage
PPE_RS14435	COG2153	protein acetylation
PPE_RS14445	COG2146	nitrite reductase [NAD(P)H] activity
PPE_RS14450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPE_RS14455	COG3707	response regulator
PPE_RS14460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPE_RS14465	COG0243	molybdopterin cofactor binding
PPE_RS14470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPE_RS14475	COG2223	nitrite transmembrane transporter activity
PPE_RS14485	COG0281	malic enzyme
PPE_RS14490	COG0679	Auxin Efflux Carrier
PPE_RS14505	COG1874	Beta-galactosidase
PPE_RS14510	COG0395	ABC-type sugar transport system, permease component
PPE_RS14515	COG4209	transmembrane transport
PPE_RS14525	COG2207	Transcriptional regulator
PPE_RS14525	COG4753	response regulator
PPE_RS14530	COG3275	phosphorelay sensor kinase activity
PPE_RS14540	COG3209	COG3209 Rhs family protein
PPE_RS14580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPE_RS14585	COG2070	2-Nitropropane dioxygenase
PPE_RS14585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPE_RS14590	COG3321	synthase
PPE_RS14595	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS14600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPE_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS14600	COG3321	synthase
PPE_RS14600	COG4221	oxidoreductase activity
PPE_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS14605	COG3321	synthase
PPE_RS14605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPE_RS14605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPE_RS14605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPE_RS14610	COG3321	synthase
PPE_RS14610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPE_RS14610	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS14610	COG4221	oxidoreductase activity
PPE_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS14615	COG3321	synthase
PPE_RS14615	COG0318	PFAM AMP-dependent synthetase and ligase
PPE_RS14615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPE_RS14615	COG0300	oxidoreductase activity
PPE_RS14620	COG1024	Enoyl-CoA hydratase
PPE_RS14625	COG1024	Enoyl-CoA hydratase
PPE_RS14630	COG3425	synthase
PPE_RS14635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPE_RS14640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPE_RS14655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPE_RS14695	COG1783	phage Terminase large subunit
PPE_RS14835	COG0592	DNA-directed DNA polymerase activity
PPE_RS14840	COG1484	DNA-dependent DNA replication
PPE_RS14855	COG3293	Transposase
PPE_RS14880	COG1742	UPF0060 membrane protein
PPE_RS14905	COG0371	Dehydrogenase
PPE_RS14950	COG0583	DNA-binding transcription factor activity
PPE_RS14965	COG1073	alpha beta
PPE_RS14975	COG1653	transport
PPE_RS14985	COG4209	transmembrane transport
PPE_RS14990	COG0395	ABC-type sugar transport system, permease component
PPE_RS14995	COG2207	Transcriptional regulator
PPE_RS15000	COG2755	lipolytic protein G-D-S-L family
PPE_RS15030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPE_RS15040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PPE_RS15055	COG0564	pseudouridine synthase activity
PPE_RS15060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PPE_RS15065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PPE_RS15080	COG3599	regulation of cell shape
PPE_RS15085	COG2302	S4 RNA-binding domain
PPE_RS15090	COG0762	integral membrane protein
PPE_RS15095	COG1799	cell septum assembly
PPE_RS15100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PPE_RS15105	COG1496	oxidoreductase activity
PPE_RS15110	COG1873	PFAM PRC-barrel domain
PPE_RS15115	COG1191	sigma factor activity
PPE_RS15120	COG1191	sigma factor activity
PPE_RS15130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPE_RS15135	COG0849	cell division
PPE_RS15140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PPE_RS15145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPE_RS15150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PPE_RS15155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPE_RS15160	COG0772	Belongs to the SEDS family
PPE_RS15165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PPE_RS15170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPE_RS15175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPE_RS15185	COG0768	penicillin binding
PPE_RS15190	COG0768	penicillin binding
PPE_RS15200	COG0275	rRNA processing
PPE_RS15205	COG2001	Belongs to the MraZ family
PPE_RS15210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PPE_RS15215	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PPE_RS15220	COG4608	Belongs to the ABC transporter superfamily
PPE_RS15225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS15230	COG0601	transmembrane transport
PPE_RS15235	COG4166	transmembrane transport
PPE_RS15245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PPE_RS15260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PPE_RS15265	COG1316	TRANSCRIPTIONal
PPE_RS15270	COG1217	gtp-binding protein TYPA
PPE_RS15280	COG0861	Integral membrane protein TerC family
PPE_RS15285	COG0861	Integral membrane protein TerC family
PPE_RS15290	COG0301	tRNA thio-modification
PPE_RS15295	COG1104	cysteine desulfurase activity
PPE_RS15300	COG0741	lytic transglycosylase activity
PPE_RS15325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS15330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS15335	COG2801	Transposase and inactivated derivatives
PPE_RS15345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PPE_RS15350	COG2384	SAM-dependent methyltransferase
PPE_RS15365	COG0358	DNA primase activity
PPE_RS15370	COG1671	Belongs to the UPF0178 family
PPE_RS15375	COG0751	glycine-tRNA ligase activity
PPE_RS15380	COG0752	glycyl-tRNA synthetase alpha subunit
PPE_RS15385	COG1381	Involved in DNA repair and RecF pathway recombination
PPE_RS15390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PPE_RS15395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PPE_RS15400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PPE_RS15405	COG1480	7TM receptor with intracellular HD hydrolase
PPE_RS15410	COG1702	phosphate starvation-inducible protein PhoH
PPE_RS15425	COG0531	amino acid
PPE_RS15435	COG4864	UPF0365 protein
PPE_RS15440	COG1030	water channel activity
PPE_RS15445	COG1610	YqeY-like protein
PPE_RS15450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PPE_RS15455	COG0537	adenosine 5'-monophosphoramidase activity
PPE_RS15460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS15470	COG0419	ATPase involved in DNA repair
PPE_RS15475	COG0420	3'-5' exonuclease activity
PPE_RS15485	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PPE_RS15500	COG1283	sodium-dependent phosphate transmembrane transporter activity
PPE_RS15510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPE_RS15515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PPE_RS15520	COG1994	Peptidase M50
PPE_RS15550	COG3493	citrate carrier protein
PPE_RS15555	COG4565	transcriptional regulatory protein
PPE_RS15560	COG3290	protein histidine kinase activity
PPE_RS15580	COG1420	regulation of RNA biosynthetic process
PPE_RS15590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPE_RS15595	COG0481	GTPase activity
PPE_RS15605	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPE_RS15610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PPE_RS15615	COG0268	Binds directly to 16S ribosomal RNA
PPE_RS15620	COG1466	dna polymerase III delta subunit
PPE_RS15630	COG1595	DNA-templated transcription, initiation
PPE_RS15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPE_RS15640	COG0658	competence protein
PPE_RS15640	COG2333	competence protein COMEC
PPE_RS15650	COG1555	photosystem II stabilization
PPE_RS15655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PPE_RS15660	COG0495	leucyl-tRNA aminoacylation
PPE_RS15665	COG1942	4-Oxalocrotonate Tautomerase
PPE_RS15670	COG2226	methyltransferase
PPE_RS15675	COG2996	Protein conserved in bacteria
PPE_RS15680	COG0799	negative regulation of ribosome biogenesis
PPE_RS15685	COG1713	HD superfamily hydrolase involved in NAD metabolism
PPE_RS15690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PPE_RS15695	COG1534	Rna-binding protein
PPE_RS15700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPE_RS15705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PPE_RS15710	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PPE_RS15715	COG1305	Transglutaminase-like
PPE_RS15725	COG0714	Associated with various cellular activities
PPE_RS15735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPE_RS15745	COG1363	Peptidase, m42
PPE_RS15755	COG4305	rare lipoprotein A
PPE_RS15765	COG1653	transport
PPE_RS15770	COG0395	ABC-type sugar transport system, permease component
PPE_RS15775	COG4209	transmembrane transport
PPE_RS15785	COG0697	spore germination
PPE_RS15795	COG1683	Conserved Protein
PPE_RS15850	COG5609	conserved protein (DUF2294)
PPE_RS15860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PPE_RS15865	COG3420	alginic acid biosynthetic process
PPE_RS15870	COG4149	molybdate abc transporter
PPE_RS15875	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPE_RS15880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPE_RS15885	COG0314	molybdopterin synthase activity
PPE_RS15895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PPE_RS15905	COG3383	formate dehydrogenase (NAD+) activity
PPE_RS15910	COG2427	Protein of unknown function (DUF1641)
PPE_RS15930	COG4977	sequence-specific DNA binding
PPE_RS15935	COG0840	transmembrane signaling receptor activity
PPE_RS15940	COG1744	ABC transporter substrate-binding protein PnrA-like
PPE_RS15950	COG1027	Aspartate ammonia-lyase
PPE_RS15960	COG0436	Aminotransferase
PPE_RS15970	COG1177	transmembrane transport
PPE_RS15975	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPE_RS15985	COG1473	amidohydrolase
PPE_RS15990	COG2171	N-acyltransferase activity
PPE_RS16000	COG0697	spore germination
PPE_RS16005	COG2897	thiosulfate sulfurtransferase activity
PPE_RS16035	COG3293	Transposase
PPE_RS16070	COG3293	Transposase
PPE_RS16160	COG0840	transmembrane signaling receptor activity
PPE_RS16175	COG1397	ADP-ribosylglycohydrolase
PPE_RS16230	COG0071	Belongs to the small heat shock protein (HSP20) family
PPE_RS16235	COG4608	Belongs to the ABC transporter superfamily
PPE_RS16240	COG0444	Belongs to the ABC transporter superfamily
PPE_RS16255	COG0747	negative chemotaxis
PPE_RS16260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS16265	COG0601	transmembrane transport
PPE_RS16280	COG2814	Major facilitator Superfamily
PPE_RS16285	COG1361	Conserved repeat domain
PPE_RS16305	COG0596	Alpha beta hydrolase
PPE_RS16310	COG0840	transmembrane signaling receptor activity
PPE_RS16315	COG2723	6-phospho-beta-galactosidase activity
PPE_RS16320	COG2190	(PTS) system
PPE_RS16320	COG1263	PTS System
PPE_RS16320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS16325	COG3711	transcriptional antiterminator
PPE_RS16335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPE_RS16345	COG0314	molybdopterin synthase activity
PPE_RS16350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPE_RS16355	COG2223	nitrite transmembrane transporter activity
PPE_RS16365	COG2197	response regulator
PPE_RS16370	COG4585	Histidine kinase
PPE_RS16380	COG2181	nitrate reductase activity
PPE_RS16390	COG1140	nitrate reductase beta subunit
PPE_RS16395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PPE_RS16400	COG4149	molybdate abc transporter
PPE_RS16405	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPE_RS16415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PPE_RS16420	COG0535	radical SAM domain protein
PPE_RS16480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPE_RS16485	COG0436	Aminotransferase
PPE_RS16490	COG1464	Belongs to the NlpA lipoprotein family
PPE_RS16500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPE_RS16525	COG2814	Major facilitator Superfamily
PPE_RS16535	COG4221	oxidoreductase activity
PPE_RS16545	COG2207	Transcriptional regulator
PPE_RS16560	COG1063	alcohol dehydrogenase
PPE_RS16575	COG1113	amino acid transport
PPE_RS16585	COG0778	Nitroreductase
PPE_RS16595	COG1846	Transcriptional regulator
PPE_RS16600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PPE_RS16610	COG0312	modulator of DNA gyrase
PPE_RS16615	COG0312	modulator of DNA gyrase
PPE_RS16680	COG0076	glutamate decarboxylase activity
PPE_RS16695	COG0693	protein deglycase activity
PPE_RS16715	COG0395	ABC-type sugar transport system, permease component
PPE_RS16735	COG2972	Histidine kinase
PPE_RS16740	COG0673	inositol 2-dehydrogenase activity
PPE_RS16755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PPE_RS16765	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS16790	COG3866	Pectate lyase
PPE_RS16795	COG0444	Belongs to the ABC transporter superfamily
PPE_RS16800	COG5002	protein histidine kinase activity
PPE_RS16805	COG0745	RESPONSE REGULATOR receiver
PPE_RS16820	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPE_RS16845	COG1404	Belongs to the peptidase S8 family
PPE_RS16845	COG4412	M6 family metalloprotease domain protein
PPE_RS16850	COG1404	Belongs to the peptidase S8 family
PPE_RS16850	COG4412	M6 family metalloprotease domain protein
PPE_RS16855	COG0659	secondary active sulfate transmembrane transporter activity
PPE_RS16870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPE_RS16875	COG2814	Major facilitator Superfamily
PPE_RS16880	COG1126	abc transporter atp-binding protein
PPE_RS16885	COG0765	amino acid transport
PPE_RS16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS16900	COG2261	transglycosylase associated protein
PPE_RS16905	COG3458	cephalosporin-C deacetylase activity
PPE_RS16915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS16940	COG2169	Transcriptional regulator
PPE_RS16955	COG2801	Transposase and inactivated derivatives
PPE_RS16960	COG4282	regulation of fungal-type cell wall biogenesis
PPE_RS17005	COG1714	RDD family
PPE_RS17010	COG1714	RDD family
PPE_RS17050	COG0484	heat shock protein binding
PPE_RS17070	COG0515	serine threonine protein kinase
PPE_RS17070	COG2815	serine threonine protein kinase
PPE_RS17075	COG2223	nitrite transmembrane transporter activity
PPE_RS17080	COG3279	Response regulator of the LytR AlgR family
PPE_RS17085	COG3275	phosphorelay sensor kinase activity
PPE_RS17090	COG1619	proteins homologs of microcin C7 resistance protein MccF
PPE_RS17100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PPE_RS17105	COG1523	belongs to the glycosyl hydrolase 13 family
PPE_RS17110	COG1132	(ABC) transporter
PPE_RS17115	COG4988	ABC transporter
PPE_RS17120	COG0246	Mannitol dehydrogenase
PPE_RS17125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS17130	COG3711	transcriptional antiterminator
PPE_RS17145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPE_RS17150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPE_RS17155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPE_RS17170	COG2190	(PTS) system
PPE_RS17170	COG1263	PTS System
PPE_RS17170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS17175	COG3711	transcriptional antiterminator
PPE_RS17180	COG2268	Band 7 protein
PPE_RS17190	COG1979	alcohol dehydrogenase
PPE_RS17195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PPE_RS17200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PPE_RS17205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PPE_RS17215	COG0667	Aldo Keto reductase
PPE_RS17220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PPE_RS17225	COG0546	phosphoglycolate phosphatase activity
PPE_RS17235	COG3594	Acyltransferase
PPE_RS17245	COG0129	dihydroxy-acid dehydratase activity
PPE_RS17255	COG0628	permease
PPE_RS17260	COG0768	penicillin binding
PPE_RS17265	COG0840	transmembrane signaling receptor activity
PPE_RS17270	COG0826	peptidase U32
PPE_RS17275	COG0826	peptidase U32
PPE_RS17280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PPE_RS17290	COG3906	Belongs to the UPF0473 family
PPE_RS17300	COG4472	Bacterial protein of unknown function (DUF965)
PPE_RS17305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPE_RS17310	COG0628	permease
PPE_RS17330	COG1104	cysteine desulfurase activity
PPE_RS17335	COG1959	2 iron, 2 sulfur cluster binding
PPE_RS17340	COG0482	sulfurtransferase activity
PPE_RS17360	COG2326	polyphosphate kinase activity
PPE_RS17365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPE_RS17370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPE_RS17375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPE_RS17380	COG3973	AAA domain
PPE_RS17385	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
PPE_RS17400	COG0281	malic enzyme
PPE_RS17415	COG3052	prosthetic group binding
PPE_RS17425	COG3493	citrate carrier protein
PPE_RS17430	COG0745	RESPONSE REGULATOR receiver
PPE_RS17435	COG1132	(ABC) transporter
PPE_RS17445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPE_RS17450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPE_RS17455	COG0124	histidyl-tRNA synthetase
PPE_RS17465	COG0693	protein deglycase activity
PPE_RS17470	COG1490	D-aminoacyl-tRNA deacylase activity
PPE_RS17475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPE_RS17485	COG0840	transmembrane signaling receptor activity
PPE_RS17490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPE_RS17495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PPE_RS17495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PPE_RS17505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPE_RS17510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPE_RS17510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPE_RS17520	COG2244	polysaccharide biosynthetic process
PPE_RS17525	COG2323	membrane
PPE_RS17535	COG1862	Preprotein translocase
PPE_RS17545	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPE_RS17550	COG2385	sporulation resulting in formation of a cellular spore
PPE_RS17550	COG2385	sporulation resulting in formation of a cellular spore
PPE_RS17555	COG2255	four-way junction helicase activity
PPE_RS17560	COG0632	four-way junction helicase activity
PPE_RS17565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PPE_RS17650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPE_RS17655	COG0077	Prephenate dehydratase
PPE_RS17660	COG0083	homoserine kinase activity
PPE_RS17665	COG0460	homoserine dehydrogenase
PPE_RS17670	COG4492	Belongs to the UPF0735 family
PPE_RS17675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPE_RS17690	COG2868	ribosomal protein
PPE_RS17695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PPE_RS17705	COG1994	Peptidase M50
PPE_RS17705	COG0517	IMP dehydrogenase activity
PPE_RS17715	COG2894	cell division
PPE_RS17720	COG0850	regulation of cytokinetic process
PPE_RS17735	COG1077	Cell shape determining protein MreB Mrl
PPE_RS17740	COG2003	Belongs to the UPF0758 family
PPE_RS17745	COG0424	maF-like protein
PPE_RS17760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPE_RS17765	COG0285	dihydrofolate synthase activity
PPE_RS17770	COG0525	valine-tRNA ligase activity
PPE_RS17775	COG1388	LysM domain
PPE_RS17780	COG0564	pseudouridine synthase activity
PPE_RS17785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPE_RS17790	COG0113	porphobilinogen synthase activity
PPE_RS17805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPE_RS17805	COG1648	precorrin-2 dehydrogenase activity
PPE_RS17820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PPE_RS17830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PPE_RS17840	COG0470	DNA polymerase III
PPE_RS17840	COG1067	ATP-dependent peptidase activity
PPE_RS17850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PPE_RS17855	COG0740	serine-type endopeptidase activity
PPE_RS17860	COG0544	peptidyl-prolyl cis-trans isomerase activity
PPE_RS17875	COG0708	Exodeoxyribonuclease III
PPE_RS17885	COG2723	6-phospho-beta-galactosidase activity
PPE_RS17890	COG0395	ABC-type sugar transport system, permease component
PPE_RS17895	COG1175	transmembrane transport
PPE_RS17910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PPE_RS17915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PPE_RS17920	COG2190	(PTS) system
PPE_RS17920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS17920	COG1263	PTS System
PPE_RS17935	COG0395	ABC-type sugar transport system, permease component
PPE_RS17940	COG1115	amino acid carrier protein
PPE_RS17950	COG0789	Transcriptional regulator
PPE_RS17955	COG2084	Dehydrogenase
PPE_RS17965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS17990	COG2723	6-phospho-beta-galactosidase activity
PPE_RS18000	COG3711	transcriptional antiterminator
PPE_RS18015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPE_RS18015	COG0662	Cupin 2, conserved barrel domain protein
PPE_RS18045	COG1216	Glycosyl transferase, family 2
PPE_RS18045	COG1442	glycosyl transferase family 8
PPE_RS18065	COG0281	malic enzyme
PPE_RS18070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PPE_RS18075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PPE_RS18080	COG0351	phosphomethylpyrimidine kinase
PPE_RS18095	COG1609	Transcriptional regulator
PPE_RS18100	COG1486	melibiose metabolic process
PPE_RS18120	COG0367	asparagine synthase
PPE_RS18125	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PPE_RS18130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PPE_RS18135	COG5401	PFAM Sporulation and spore germination
PPE_RS18140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPE_RS18150	COG0300	oxidoreductase activity
PPE_RS18160	COG0702	epimerase
PPE_RS18170	COG2226	methyltransferase
PPE_RS18175	COG1801	Protein of unknown function DUF72
PPE_RS18180	COG0457	Tetratricopeptide repeat
PPE_RS18180	COG0463	Glycosyl transferase, family 2
PPE_RS18185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPE_RS18195	COG1086	Polysaccharide biosynthesis protein
PPE_RS18210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PPE_RS18210	COG2755	lipolytic protein G-D-S-L family
PPE_RS18220	COG0840	transmembrane signaling receptor activity
PPE_RS18225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PPE_RS18245	COG2197	response regulator
PPE_RS18250	COG2822	iron ion transport
PPE_RS18255	COG2837	iron assimilation
PPE_RS18260	COG0672	)-iron permease
PPE_RS18295	COG1131	(ABC) transporter
PPE_RS18305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPE_RS18325	COG1737	Transcriptional regulator
PPE_RS18330	COG0363	glucosamine-6-phosphate deaminase activity
PPE_RS18335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PPE_RS18405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPE_RS18405	COG1263	PTS System
PPE_RS18405	COG2190	(PTS) system
PPE_RS18410	COG3192	ethanolamine utilization protein
PPE_RS18425	COG1609	Transcriptional regulator
PPE_RS18435	COG0492	ferredoxin-NADP+ reductase activity
PPE_RS18440	COG1959	2 iron, 2 sulfur cluster binding
PPE_RS18445	COG3711	transcriptional antiterminator
PPE_RS18445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS18450	COG1447	Phosphotransferase system cellobiose-specific component IIA
PPE_RS18455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPE_RS18460	COG2723	6-phospho-beta-galactosidase activity
PPE_RS18520	COG0463	Glycosyl transferase, family 2
PPE_RS18535	COG1086	Polysaccharide biosynthesis protein
PPE_RS18580	COG1216	Glycosyl transferase, family 2
PPE_RS18580	COG0438	transferase activity, transferring glycosyl groups
PPE_RS18585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PPE_RS18605	COG3227	Zinc metalloprotease (Elastase)
PPE_RS18610	COG3227	Zinc metalloprotease (Elastase)
PPE_RS18620	COG0438	transferase activity, transferring glycosyl groups
PPE_RS18630	COG0688	phosphatidylethanolamine metabolic process
PPE_RS18655	COG1131	(ABC) transporter
PPE_RS18665	COG0300	oxidoreductase activity
PPE_RS18675	COG0583	DNA-binding transcription factor activity
PPE_RS18680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PPE_RS18685	COG2357	RelA SpoT domain protein
PPE_RS18710	COG1408	metallophosphoesterase
PPE_RS18715	COG2746	aminoglycoside 3-N-acetyltransferase activity
PPE_RS18720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PPE_RS18725	COG1053	succinate dehydrogenase
PPE_RS18730	COG2009	succinate dehydrogenase
PPE_RS18735	COG0583	DNA-binding transcription factor activity
PPE_RS18740	COG0569	domain protein
PPE_RS18745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPE_RS18755	COG0322	excinuclease ABC activity
PPE_RS18760	COG3118	belongs to the thioredoxin family
PPE_RS18765	COG1484	DNA-dependent DNA replication
PPE_RS18775	COG3253	May function as heme-dependent peroxidase
PPE_RS18795	COG1252	NADH dehydrogenase
PPE_RS18800	COG0492	ferredoxin-NADP+ reductase activity
PPE_RS18810	COG0189	ligase activity
PPE_RS18815	COG0248	Ppx GppA phosphatase
PPE_RS18820	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PPE_RS18830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPE_RS18835	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPE_RS18860	COG0697	spore germination
PPE_RS18865	COG0583	DNA-binding transcription factor activity
PPE_RS18870	COG2323	membrane
PPE_RS18880	COG1595	DNA-templated transcription, initiation
PPE_RS18905	COG0316	Belongs to the HesB IscA family
PPE_RS18915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPE_RS18920	COG1252	NADH dehydrogenase
PPE_RS18930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPE_RS18935	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS18940	COG1464	Belongs to the NlpA lipoprotein family
PPE_RS18945	COG2011	ABC-type metal ion transport system permease component
PPE_RS18950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPE_RS18960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPE_RS18965	COG1612	heme a metabolic process
PPE_RS18970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPE_RS18990	COG0561	phosphatase activity
PPE_RS18995	COG0768	penicillin binding
PPE_RS19000	COG0768	penicillin binding
PPE_RS19020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PPE_RS19025	COG0109	protoheme IX farnesyltransferase activity
PPE_RS19030	COG1988	membrane-bound metal-dependent
PPE_RS19040	COG0180	Tryptophanyl-tRNA synthetase
PPE_RS19075	COG2346	COG2346, Truncated hemoglobins
PPE_RS19080	COG3314	Sporulation integral membrane protein YlbJ
PPE_RS19085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PPE_RS19090	COG4470	Protein conserved in bacteria
PPE_RS19095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPE_RS19100	COG0739	heme binding
PPE_RS19110	COG0667	Aldo Keto reductase
PPE_RS19120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PPE_RS19130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPE_RS19135	COG2169	Transcriptional regulator
PPE_RS19140	COG1115	amino acid carrier protein
PPE_RS19150	COG3711	transcriptional antiterminator
PPE_RS19155	COG2723	6-phospho-beta-galactosidase activity
PPE_RS19165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPE_RS19170	COG0569	domain protein
PPE_RS19180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PPE_RS19185	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPE_RS19200	COG2197	response regulator
PPE_RS19205	COG4585	Histidine kinase
PPE_RS19215	COG1842	Phage shock protein A
PPE_RS19225	COG1842	Phage shock protein A
PPE_RS19235	COG2814	Major facilitator Superfamily
PPE_RS19335	COG3858	chitin binding
PPE_RS19340	COG0735	belongs to the Fur family
PPE_RS19355	COG1285	pathogenesis
PPE_RS19360	COG0456	acetyltransferase
PPE_RS19360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PPE_RS19365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPE_RS19370	COG0154	amidase activity
PPE_RS19375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPE_RS19390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPE_RS19400	COG0586	Pfam SNARE associated Golgi protein
PPE_RS19425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPE_RS19435	COG4840	Belongs to the UPF0435 family
PPE_RS19445	COG0671	phosphoesterase, PA-phosphatase related
PPE_RS19450	COG2261	transglycosylase associated protein
PPE_RS19465	COG0598	Magnesium transport protein CorA
PPE_RS19470	COG1191	sigma factor activity
PPE_RS19480	COG1366	Belongs to the anti-sigma-factor antagonist family
PPE_RS19485	COG0784	Response regulator, receiver
PPE_RS19485	COG2205	protein histidine kinase activity
PPE_RS19490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPE_RS19495	COG2205	protein histidine kinase activity
PPE_RS19495	COG5002	protein histidine kinase activity
PPE_RS19495	COG0784	Response regulator, receiver
PPE_RS19500	COG2208	phosphoserine phosphatase activity
PPE_RS19530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPE_RS19545	COG0488	(ABC) transporter
PPE_RS19550	COG1120	ATPase activity
PPE_RS19565	COG5386	Cell surface protein
PPE_RS19575	COG5386	Cell surface protein
PPE_RS19590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS19600	COG2329	Antibiotic biosynthesis monooxygenase
PPE_RS19605	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PPE_RS19610	COG1294	oxidase, subunit
PPE_RS19615	COG1271	oxidase subunit
PPE_RS19620	COG1846	Transcriptional regulator
PPE_RS19625	COG2814	Major facilitator Superfamily
PPE_RS19630	COG1413	lyase activity
PPE_RS19635	COG0833	amino acid
PPE_RS19640	COG2211	Major facilitator Superfamily
PPE_RS19660	COG1070	Carbohydrate kinase
PPE_RS19665	COG2115	Belongs to the xylose isomerase family
PPE_RS19695	COG0655	NAD(P)H dehydrogenase (quinone) activity
PPE_RS19700	COG1566	PFAM secretion protein HlyD family protein
PPE_RS19705	COG2814	Major facilitator Superfamily
PPE_RS19710	COG2217	Heavy metal translocating P-type atpase
PPE_RS19720	COG2217	Heavy metal translocating P-type atpase
PPE_RS19725	COG0640	Transcriptional regulator
PPE_RS19735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PPE_RS19745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PPE_RS19750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PPE_RS19760	COG2723	6-phospho-beta-galactosidase activity
PPE_RS19775	COG0395	ABC-type sugar transport system, permease component
PPE_RS19780	COG4209	transmembrane transport
PPE_RS19790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PPE_RS19795	COG4988	ABC transporter
PPE_RS19800	COG1294	oxidase, subunit
PPE_RS19805	COG1271	oxidase subunit
PPE_RS19810	COG4753	response regulator
PPE_RS19810	COG2207	Transcriptional regulator
PPE_RS19815	COG2972	Histidine kinase
PPE_RS19835	COG5039	Polysaccharide pyruvyl transferase
PPE_RS19860	COG1253	flavin adenine dinucleotide binding
PPE_RS19870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPE_RS19875	COG0667	Aldo Keto reductase
PPE_RS19880	COG2819	hydrolase of the alpha beta superfamily
PPE_RS19885	COG4607	ABC-type enterochelin transport system periplasmic component
PPE_RS19890	COG4604	ABC transporter, ATP-binding protein
PPE_RS19895	COG4605	iron ion homeostasis
PPE_RS19900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPE_RS19905	COG0745	RESPONSE REGULATOR receiver
PPE_RS19915	COG1136	(ABC) transporter
PPE_RS19930	COG0346	lactoylglutathione lyase activity
PPE_RS19940	COG0351	phosphomethylpyrimidine kinase
PPE_RS19950	COG0737	Belongs to the 5'-nucleotidase family
PPE_RS19955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPE_RS19965	COG3639	organic phosphonate transmembrane transporter activity
PPE_RS19975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPE_RS19980	COG4208	sulfate ABC transporter
PPE_RS19985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PPE_RS19990	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PPE_RS20005	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PPE_RS20015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PPE_RS20020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PPE_RS20035	COG2390	Transcriptional regulator
PPE_RS20055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPE_RS20055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPE_RS20070	COG1733	regulation of RNA biosynthetic process
PPE_RS20075	COG1733	regulation of RNA biosynthetic process
PPE_RS20095	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPE_RS20100	COG1733	regulation of RNA biosynthetic process
PPE_RS20105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPE_RS20110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PPE_RS20115	COG0640	Transcriptional regulator
PPE_RS20120	COG0596	Alpha beta hydrolase
PPE_RS20125	COG2814	Major facilitator Superfamily
PPE_RS20140	COG2207	Transcriptional regulator
PPE_RS20150	COG1846	Transcriptional regulator
PPE_RS20150	COG0456	acetyltransferase
PPE_RS20160	COG1819	glycosyl
PPE_RS20185	COG1609	Transcriptional regulator
PPE_RS20195	COG2273	Hydrolase Family 16
PPE_RS20205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PPE_RS20205	COG0392	lysyltransferase activity
PPE_RS20225	COG5002	protein histidine kinase activity
PPE_RS20235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPE_RS20255	COG0586	Pfam SNARE associated Golgi protein
PPE_RS20270	COG5002	protein histidine kinase activity
PPE_RS20280	COG1132	(ABC) transporter
PPE_RS20285	COG1132	(ABC) transporter
PPE_RS20415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPE_RS20425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PPE_RS20430	COG5662	AntiSigma factor
PPE_RS20435	COG1595	DNA-templated transcription, initiation
PPE_RS20440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PPE_RS20540	COG0726	polysaccharide deacetylase
PPE_RS20550	COG0489	protein tyrosine kinase activity
PPE_RS20555	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPE_RS20560	COG2046	Belongs to the sulfate adenylyltransferase family
PPE_RS20565	COG0175	sulfate reduction
PPE_RS20570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PPE_RS20575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PPE_RS20580	COG0101	tRNA pseudouridine synthase activity
PPE_RS20585	COG0203	ribosomal protein L17
PPE_RS20590	COG0202	RNA polymerase activity
PPE_RS20595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PPE_RS20600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PPE_RS20605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PPE_RS20610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PPE_RS20620	COG0024	Methionine aminopeptidase
PPE_RS20625	COG0563	adenylate kinase activity
PPE_RS20630	COG0201	protein transport
PPE_RS20635	COG0200	Binds to the 23S rRNA
PPE_RS20640	COG1841	ribosomal large subunit assembly
PPE_RS20645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PPE_RS20650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PPE_RS20655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PPE_RS20660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PPE_RS20665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PPE_RS20670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PPE_RS20675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PPE_RS20680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PPE_RS20685	COG0255	Belongs to the universal ribosomal protein uL29 family
PPE_RS20690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PPE_RS20695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PPE_RS20700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PPE_RS20715	COG0089	rRNA binding
PPE_RS20720	COG0088	Forms part of the polypeptide exit tunnel
PPE_RS20725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PPE_RS20745	COG0049	tRNA binding
PPE_RS20750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PPE_RS20755	COG1358	cellular component organization or biogenesis
PPE_RS20760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PPE_RS20765	COG0085	RNA polymerase activity
PPE_RS20770	COG2813	Specifically methylates the guanine in position
PPE_RS20775	COG0222	ribosome binding
PPE_RS20780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PPE_RS20785	COG0081	regulation of translation
PPE_RS20790	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PPE_RS20795	COG0250	Participates in transcription elongation, termination and antitermination
PPE_RS20800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPE_RS20810	COG3688	RNA-binding protein containing a PIN domain
PPE_RS20815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPE_RS20820	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PPE_RS20825	COG0215	cysteine-tRNA ligase activity
PPE_RS20830	COG1045	serine acetyltransferase
PPE_RS20835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPE_RS20840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PPE_RS20845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PPE_RS20850	COG4956	integral membrane protein (PIN domain superfamily)
PPE_RS20855	COG1183	phosphatidylcholine synthase activity
PPE_RS20860	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PPE_RS20865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PPE_RS20870	COG0542	response to heat
PPE_RS20875	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PPE_RS20880	COG3880	PFAM UvrB UvrC protein
PPE_RS20915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPE_RS20920	COG0210	DNA helicase
PPE_RS20925	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PPE_RS20950	COG1091	dTDP-4-dehydrorhamnose reductase activity
PPE_RS20975	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PPE_RS20985	COG1216	Glycosyl transferase, family 2
PPE_RS20985	COG0463	Glycosyl transferase, family 2
PPE_RS20990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PPE_RS20990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PPE_RS20995	COG0367	asparagine synthase
PPE_RS21005	COG1682	transport, permease protein
PPE_RS21015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPE_RS21020	COG0463	Glycosyl transferase, family 2
PPE_RS21030	COG0826	peptidase U32
PPE_RS21040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPE_RS21045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPE_RS21055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPE_RS21060	COG0556	nucleotide-excision repair
PPE_RS21065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPE_RS21070	COG1360	Flagellar Motor Protein
PPE_RS21100	COG1595	DNA-templated transcription, initiation
PPE_RS21140	COG3409	Peptidoglycan-binding domain 1 protein
PPE_RS21140	COG0793	Belongs to the peptidase S41A family
PPE_RS21145	COG0741	lytic transglycosylase activity
PPE_RS21145	COG0739	heme binding
PPE_RS21145	COG1196	nuclear chromosome segregation
PPE_RS21150	COG2177	Part of the ABC transporter FtsEX involved in
PPE_RS21155	COG2884	Cell division ATP-binding protein ftsE
PPE_RS21160	COG2720	vancomycin resistance protein
PPE_RS21190	COG0463	Glycosyl transferase, family 2
PPE_RS21205	COG0165	Argininosuccinate lyase
PPE_RS21210	COG0137	argininosuccinate synthase activity
PPE_RS21215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPE_RS21225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPE_RS21230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PPE_RS21235	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPE_RS21240	COG3386	PFAM SMP-30 Gluconolaconase
PPE_RS21245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPE_RS21250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PPE_RS21255	COG0653	protein targeting
PPE_RS21260	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PPE_RS21270	COG1278	Cold shock
PPE_RS21275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PPE_RS21285	COG0028	Belongs to the TPP enzyme family
PPE_RS21285	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PPE_RS21295	COG3119	arylsulfatase activity
PPE_RS21300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PPE_RS21310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PPE_RS21315	COG2089	acid synthase
PPE_RS21325	COG1086	Polysaccharide biosynthesis protein
PPE_RS21345	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PPE_RS21355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PPE_RS21370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PPE_RS21375	COG4786	Flagellar basal body rod
PPE_RS21375	COG1256	bacterial-type flagellum assembly
PPE_RS21380	COG3418	PFAM FlgN family protein
PPE_RS21395	COG1388	LysM domain
PPE_RS21400	COG1040	competence protein
PPE_RS21405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PPE_RS21440	COG1309	transcriptional regulator
PPE_RS21445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PPE_RS21485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPE_RS21505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPE_RS21510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPE_RS21525	COG4786	Flagellar basal body rod
PPE_RS21535	COG1609	Transcriptional regulator
PPE_RS21540	COG0739	heme binding
PPE_RS21545	COG2385	sporulation resulting in formation of a cellular spore
PPE_RS21550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPE_RS21560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPE_RS21565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPE_RS21570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPE_RS21575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPE_RS21580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPE_RS21585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPE_RS21595	COG0356	it plays a direct role in the translocation of protons across the membrane
PPE_RS21610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PPE_RS21615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PPE_RS21635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPE_RS21640	COG4475	Protein of unknown function (DUF436)
PPE_RS21650	COG1971	Probably functions as a manganese efflux pump
PPE_RS21655	COG0009	L-threonylcarbamoyladenylate synthase
PPE_RS21665	COG0772	Belongs to the SEDS family
PPE_RS21670	COG2890	protein-(glutamine-N5) methyltransferase activity
PPE_RS21675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPE_RS21680	COG0012	GTP binding
PPE_RS21685	COG0456	acetyltransferase
PPE_RS21690	COG1304	FMN binding
PPE_RS21715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPE_RS21725	COG2076	Multidrug Resistance protein
PPE_RS21730	COG2076	Multidrug Resistance protein
PPE_RS21745	COG0746	molybdenum cofactor guanylyltransferase activity
PPE_RS21755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPE_RS21775	COG2814	Major facilitator Superfamily
PPE_RS21780	COG0243	molybdopterin cofactor binding
PPE_RS21785	COG2116	formate transmembrane transporter activity
PPE_RS21790	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPE_RS21795	COG0386	Belongs to the glutathione peroxidase family
PPE_RS21805	COG1120	ATPase activity
PPE_RS21810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS21815	COG0628	permease
PPE_RS21820	COG1316	TRANSCRIPTIONal
PPE_RS21825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPE_RS21925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS21930	COG1126	abc transporter atp-binding protein
PPE_RS21935	COG0765	amino acid transport
PPE_RS21940	COG0765	amino acid transport
PPE_RS21945	COG0659	secondary active sulfate transmembrane transporter activity
PPE_RS21955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PPE_RS21970	COG2002	toxin-antitoxin pair type II binding
PPE_RS22000	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PPE_RS22025	COG1611	Belongs to the LOG family
PPE_RS22030	COG1587	Uroporphyrinogen-III synthase
PPE_RS22035	COG0531	amino acid
PPE_RS22050	COG0697	spore germination
PPE_RS22070	COG0697	spore germination
PPE_RS22075	COG0840	transmembrane signaling receptor activity
PPE_RS22080	COG2259	Doxx family
PPE_RS22095	COG0745	RESPONSE REGULATOR receiver
PPE_RS22115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PPE_RS22125	COG0697	spore germination
PPE_RS22130	COG3706	GGDEF domain
PPE_RS22140	COG1472	Belongs to the glycosyl hydrolase 3 family
PPE_RS22145	COG2002	toxin-antitoxin pair type II binding
PPE_RS22160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PPE_RS22185	COG0300	oxidoreductase activity
PPE_RS22200	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PPE_RS22205	COG0783	Belongs to the Dps family
PPE_RS22210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PPE_RS22215	COG3842	ATPase activity
PPE_RS22225	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPE_RS22340	COG1846	Transcriptional regulator
PPE_RS22350	COG3706	GGDEF domain
PPE_RS22355	COG0583	DNA-binding transcription factor activity
PPE_RS22360	COG1380	Effector of murein hydrolase LrgA
PPE_RS22365	COG1346	cytolysis
PPE_RS22370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PPE_RS22375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PPE_RS22380	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PPE_RS22390	COG2910	NAD(P)H-binding
PPE_RS22395	COG0475	glutathione-regulated potassium exporter activity
PPE_RS22415	COG2807	transmembrane transport
PPE_RS22420	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS22425	COG0800	Aldolase
PPE_RS22430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PPE_RS22435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPE_RS22440	COG1609	Transcriptional regulator
PPE_RS22445	COG0534	Mate efflux family protein
PPE_RS22450	COG0604	alcohol dehydrogenase
PPE_RS22455	COG1595	DNA-templated transcription, initiation
PPE_RS22465	COG0395	ABC-type sugar transport system, permease component
PPE_RS22470	COG1175	transmembrane transport
PPE_RS22475	COG1653	transport
PPE_RS22490	COG1131	(ABC) transporter
PPE_RS22495	COG0488	(ABC) transporter
PPE_RS22500	COG2814	Major facilitator Superfamily
PPE_RS22505	COG3458	cephalosporin-C deacetylase activity
PPE_RS22510	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
PPE_RS22515	COG0395	ABC-type sugar transport system, permease component
PPE_RS22525	COG2182	Extracellular solute-binding protein
PPE_RS22530	COG2942	2-epimerase
PPE_RS22535	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
PPE_RS22540	COG1609	Transcriptional regulator
PPE_RS22550	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
PPE_RS22565	COG1252	NADH dehydrogenase
PPE_RS22585	COG0588	phosphoglycerate mutase activity
PPE_RS22605	COG1609	Transcriptional regulator
PPE_RS22610	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPE_RS22615	COG0840	transmembrane signaling receptor activity
PPE_RS22625	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PPE_RS22630	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPE_RS22635	COG3693	PFAM glycoside hydrolase, family 10
PPE_RS22650	COG3275	phosphorelay sensor kinase activity
PPE_RS22655	COG2207	Transcriptional regulator
PPE_RS22655	COG4753	response regulator
PPE_RS22670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPE_RS22675	COG1773	rubredoxin
PPE_RS22680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPE_RS22690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPE_RS22695	COG0702	epimerase
PPE_RS22700	COG1309	transcriptional regulator
PPE_RS22705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPE_RS22710	COG0390	transport system, permease component
PPE_RS22715	COG3729	General stress protein
PPE_RS22735	COG2002	toxin-antitoxin pair type II binding
PPE_RS22770	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS22790	COG0366	Alpha amylase catalytic
PPE_RS22790	COG1874	Beta-galactosidase
PPE_RS22820	COG1132	(ABC) transporter
PPE_RS22825	COG1902	pentaerythritol trinitrate reductase activity
PPE_RS22835	COG4753	response regulator
PPE_RS22835	COG2207	Transcriptional regulator
PPE_RS22840	COG2972	Histidine kinase
PPE_RS22855	COG3290	protein histidine kinase activity
PPE_RS22855	COG0840	transmembrane signaling receptor activity
PPE_RS22875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PPE_RS22885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PPE_RS22885	COG2755	lipolytic protein G-D-S-L family
PPE_RS22890	COG0733	neurotransmitter:sodium symporter activity
PPE_RS22915	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PPE_RS22930	COG2188	Transcriptional regulator
PPE_RS22935	COG2723	6-phospho-beta-galactosidase activity
PPE_RS22940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPE_RS22945	COG1447	Phosphotransferase system cellobiose-specific component IIA
PPE_RS22950	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPE_RS22975	COG4166	transmembrane transport
PPE_RS22995	COG0252	asparaginase activity
PPE_RS23000	COG1126	abc transporter atp-binding protein
PPE_RS23005	COG0765	amino acid transport
PPE_RS23010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPE_RS23015	COG1124	(ABC) transporter
PPE_RS23025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS23030	COG0601	transmembrane transport
PPE_RS23035	COG0747	negative chemotaxis
PPE_RS23045	COG0444	Belongs to the ABC transporter superfamily
PPE_RS23050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS23055	COG0601	transmembrane transport
PPE_RS23060	COG0747	negative chemotaxis
PPE_RS23065	COG2233	PERMEase
PPE_RS23070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPE_RS23080	COG4806	L-rhamnose isomerase
PPE_RS23085	COG0235	Class ii aldolase
PPE_RS23090	COG0662	Cupin 2, conserved barrel domain protein
PPE_RS23090	COG2207	Transcriptional regulator
PPE_RS23100	COG2040	homocysteine
PPE_RS23115	COG0167	dihydroorotate dehydrogenase activity
PPE_RS23120	COG0543	2 iron, 2 sulfur cluster binding
PPE_RS23125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPE_RS23130	COG2207	Transcriptional regulator
PPE_RS23130	COG3708	Transcriptional regulator
PPE_RS23135	COG0583	DNA-binding transcription factor activity
PPE_RS23140	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS23150	COG1733	regulation of RNA biosynthetic process
PPE_RS23155	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS23165	COG0386	Belongs to the glutathione peroxidase family
PPE_RS23175	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS23190	COG0322	excinuclease ABC activity
PPE_RS23205	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PPE_RS23205	COG0028	Belongs to the TPP enzyme family
PPE_RS23210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PPE_RS23230	COG0667	Aldo Keto reductase
PPE_RS23240	COG0745	RESPONSE REGULATOR receiver
PPE_RS23245	COG2205	protein histidine kinase activity
PPE_RS23250	COG1136	(ABC) transporter
PPE_RS23255	COG0577	efflux transmembrane transporter activity
PPE_RS23265	COG0667	Aldo Keto reductase
PPE_RS23270	COG0535	radical SAM domain protein
PPE_RS23280	COG2210	Belongs to the sulfur carrier protein TusA family
PPE_RS23290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS23300	COG2824	Alkylphosphonate utilization operon protein PhnA
PPE_RS23305	COG0702	epimerase
PPE_RS23310	COG1597	lipid kinase activity
PPE_RS23320	COG4589	Belongs to the CDS family
PPE_RS23325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPE_RS23330	COG0697	spore germination
PPE_RS23335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPE_RS23335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS23335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPE_RS23340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPE_RS23340	COG3711	transcriptional antiterminator
PPE_RS23365	COG3835	regulator
PPE_RS23370	COG1929	Belongs to the glycerate kinase type-1 family
PPE_RS23375	COG2610	gluconate transmembrane transporter activity
PPE_RS23400	COG3693	PFAM glycoside hydrolase, family 10
PPE_RS23405	COG0657	acetylesterase activity
PPE_RS23415	COG1309	transcriptional regulator
PPE_RS23435	COG0579	oxidoreductase
PPE_RS23445	COG2160	L-arabinose isomerase activity
PPE_RS23450	COG0235	Class ii aldolase
PPE_RS23460	COG1609	Transcriptional regulator
PPE_RS23490	COG1309	transcriptional regulator
PPE_RS23495	COG2353	YceI-like domain
PPE_RS23505	COG0477	Major facilitator Superfamily
PPE_RS23525	COG3693	PFAM glycoside hydrolase, family 10
PPE_RS23525	COG3507	Belongs to the glycosyl hydrolase 43 family
PPE_RS23525	COG2382	esterase
PPE_RS23540	COG2340	Cysteine-rich secretory protein family
PPE_RS23545	COG0640	Transcriptional regulator
PPE_RS23550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS23555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS23560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPE_RS23565	COG1902	pentaerythritol trinitrate reductase activity
PPE_RS23570	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS23580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPE_RS23585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PPE_RS23590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PPE_RS23595	COG4221	oxidoreductase activity
PPE_RS23605	COG2084	Dehydrogenase
PPE_RS23610	COG0789	Transcriptional regulator
PPE_RS23615	COG0657	acetylesterase activity
PPE_RS23630	COG1846	Transcriptional regulator
PPE_RS23635	COG0277	FAD linked oxidase domain protein
PPE_RS23640	COG0840	transmembrane signaling receptor activity
PPE_RS23655	COG1733	regulation of RNA biosynthetic process
PPE_RS23670	COG0492	ferredoxin-NADP+ reductase activity
PPE_RS23685	COG2814	Major facilitator Superfamily
PPE_RS23695	COG1309	transcriptional regulator
PPE_RS23700	COG0667	Aldo Keto reductase
PPE_RS23705	COG1028	Short-chain dehydrogenase reductase Sdr
PPE_RS23760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPE_RS23770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPE_RS23785	COG5002	protein histidine kinase activity
PPE_RS23790	COG0745	RESPONSE REGULATOR receiver
PPE_RS23795	COG0739	heme binding
PPE_RS23805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PPE_RS23810	COG0305	Participates in initiation and elongation during chromosome replication
PPE_RS23815	COG0359	binds to the 23S rRNA
PPE_RS23820	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PPE_RS23850	COG4608	Belongs to the ABC transporter superfamily
PPE_RS23855	COG0444	Belongs to the ABC transporter superfamily
PPE_RS23860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPE_RS23865	COG0601	transmembrane transport
PPE_RS23870	COG4166	transmembrane transport
PPE_RS23875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PPE_RS23880	COG0629	single-stranded DNA binding
PPE_RS23885	COG0360	Binds together with S18 to 16S ribosomal RNA
PPE_RS23905	COG4481	Protein conserved in bacteria
PPE_RS23910	COG0668	transmembrane transport
PPE_RS23925	COG1475	DNA binding
PPE_RS23930	COG1192	Involved in chromosome partitioning
PPE_RS23935	COG1475	DNA binding
PPE_RS23940	COG0357	Ribosomal RNA small subunit methyltransferase G
PPE_RS23945	COG0445	tRNA wobble uridine modification
PPE_RS23950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPE_RS23955	COG1847	R3H domain protein
PPE_RS23965	COG0594	ribonuclease P activity
PPE_RS23970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PPE_RS23985	COG0840	transmembrane signaling receptor activity
PPE_RS24005	COG0444	Belongs to the ABC transporter superfamily
PPE_RS24025	COG2376	Dihydroxyacetone kinase
PPE_RS24040	COG0492	ferredoxin-NADP+ reductase activity
PPE_RS24055	COG2202	Pas domain
PPE_RS24055	COG1366	Belongs to the anti-sigma-factor antagonist family
PPE_RS24110	COG1733	regulation of RNA biosynthetic process