locus-tag	class	description
PPYC1_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PPYC1_RS00010	COG0592	DNA-directed DNA polymerase activity
PPYC1_RS00015	COG2501	S4 domain
PPYC1_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PPYC1_RS00030	COG0187	DNA topoisomerase II activity
PPYC1_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PPYC1_RS00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPYC1_RS00080	COG1982	Orn Lys Arg decarboxylase major
PPYC1_RS00085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PPYC1_RS00090	COG3870	Protein conserved in bacteria
PPYC1_RS00095	COG1728	Protein conserved in bacteria
PPYC1_RS00100	COG0470	DNA polymerase III
PPYC1_RS00105	COG1774	PSP1 C-terminal conserved region
PPYC1_RS00110	COG4467	Involved in initiation control of chromosome replication
PPYC1_RS00115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PPYC1_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PPYC1_RS00125	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS00130	COG1078	dGTPase activity
PPYC1_RS00135	COG0084	hydrolase, TatD family'
PPYC1_RS00140	COG3584	3D domain protein
PPYC1_RS00140	COG3583	domain protein
PPYC1_RS00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PPYC1_RS00160	COG4466	Protein conserved in bacteria
PPYC1_RS00170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PPYC1_RS00175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPYC1_RS00180	COG2088	sporulation resulting in formation of a cellular spore
PPYC1_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PPYC1_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PPYC1_RS00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PPYC1_RS00215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PPYC1_RS00220	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS00225	COG2244	polysaccharide biosynthetic process
PPYC1_RS00230	COG3956	TIGRFAM MazG family protein
PPYC1_RS00240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PPYC1_RS00260	COG1098	S1 RNA binding domain
PPYC1_RS00265	COG2208	phosphoserine phosphatase activity
PPYC1_RS00275	COG0515	serine threonine protein kinase
PPYC1_RS00290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPYC1_RS00300	COG0157	Belongs to the NadC ModD family
PPYC1_RS00305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PPYC1_RS00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPYC1_RS00325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PPYC1_RS00330	COG0512	Glutamine amidotransferase of anthranilate synthase
PPYC1_RS00335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPYC1_RS00340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PPYC1_RS00345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PPYC1_RS00350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PPYC1_RS00355	COG1396	sequence-specific DNA binding
PPYC1_RS00360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPYC1_RS00365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PPYC1_RS00375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPYC1_RS00390	COG0318	PFAM AMP-dependent synthetase and ligase
PPYC1_RS00395	COG1012	belongs to the aldehyde dehydrogenase family
PPYC1_RS00400	COG0028	Belongs to the TPP enzyme family
PPYC1_RS00405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPYC1_RS00410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPYC1_RS00440	COG0516	GMP reductase activity
PPYC1_RS00440	COG0517	IMP dehydrogenase activity
PPYC1_RS00445	COG1686	Belongs to the peptidase S11 family
PPYC1_RS00475	COG0280	phosphate acetyltransferase
PPYC1_RS00480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPYC1_RS00505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS00510	COG0590	tRNA wobble adenosine to inosine editing
PPYC1_RS00515	COG5002	protein histidine kinase activity
PPYC1_RS00520	COG1187	pseudouridine synthase activity
PPYC1_RS00525	COG1360	Flagellar Motor Protein
PPYC1_RS00530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPYC1_RS00540	COG2154	pterin-4-alpha-carbinolamine dehydratase
PPYC1_RS00550	COG0791	NLP P60 protein
PPYC1_RS00570	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS00575	COG1733	regulation of RNA biosynthetic process
PPYC1_RS00580	COG2190	(PTS) system
PPYC1_RS00600	COG1357	PFAM Pentapeptide repeats (8 copies)
PPYC1_RS00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPYC1_RS00630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PPYC1_RS00635	COG2211	Major facilitator Superfamily
PPYC1_RS00640	COG1132	(ABC) transporter
PPYC1_RS00650	COG0583	DNA-binding transcription factor activity
PPYC1_RS00660	COG0018	arginyl-trna synthetase
PPYC1_RS00670	COG0583	DNA-binding transcription factor activity
PPYC1_RS00675	COG3842	ATPase activity
PPYC1_RS00685	COG1177	transmembrane transport
PPYC1_RS00690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PPYC1_RS00695	COG1404	Belongs to the peptidase S8 family
PPYC1_RS00700	COG3343	RNA polymerase activity
PPYC1_RS00705	COG0504	CTP synthase activity
PPYC1_RS00710	COG2204	response regulator
PPYC1_RS00720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPYC1_RS00725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PPYC1_RS00735	COG0254	rRNA binding
PPYC1_RS00745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PPYC1_RS00750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PPYC1_RS00755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PPYC1_RS00835	COG2508	Transcriptional regulator
PPYC1_RS00840	COG3842	ATPase activity
PPYC1_RS00845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PPYC1_RS00850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PPYC1_RS00855	COG0546	phosphoglycolate phosphatase activity
PPYC1_RS00860	COG0110	maltose O-acetyltransferase activity
PPYC1_RS00870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PPYC1_RS00875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PPYC1_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PPYC1_RS00885	COG0131	Imidazoleglycerol-phosphate dehydratase
PPYC1_RS00890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PPYC1_RS00895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PPYC1_RS00900	COG0107	imidazoleglycerol-phosphate synthase activity
PPYC1_RS00905	COG0140	phosphoribosyl-ATP diphosphatase activity
PPYC1_RS00905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PPYC1_RS00910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PPYC1_RS00925	COG1940	carbohydrate kinase activity
PPYC1_RS00930	COG1660	Displays ATPase and GTPase activities
PPYC1_RS00935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PPYC1_RS00940	COG1481	regulation of sporulation
PPYC1_RS00945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS00960	COG0740	serine-type endopeptidase activity
PPYC1_RS00980	COG0126	phosphoglycerate kinase activity
PPYC1_RS00985	COG0149	triose-phosphate isomerase activity
PPYC1_RS00995	COG0148	phosphopyruvate hydratase activity
PPYC1_RS01000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPYC1_RS01005	COG0557	exoribonuclease II activity
PPYC1_RS01010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PPYC1_RS01020	COG4224	UPF0291 protein
PPYC1_RS01025	COG2259	Doxx family
PPYC1_RS01030	COG0346	lactoylglutathione lyase activity
PPYC1_RS01035	COG1733	regulation of RNA biosynthetic process
PPYC1_RS01040	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS01045	COG1216	Glycosyl transferase, family 2
PPYC1_RS01050	COG2188	Transcriptional regulator
PPYC1_RS01055	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
PPYC1_RS01065	COG1842	Phage shock protein A
PPYC1_RS01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPYC1_RS01075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PPYC1_RS01080	COG4260	virion core protein, lumpy skin disease virus
PPYC1_RS01095	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS01095	COG2207	Transcriptional regulator
PPYC1_RS01110	COG0534	Mate efflux family protein
PPYC1_RS01115	COG0604	alcohol dehydrogenase
PPYC1_RS01135	COG4977	sequence-specific DNA binding
PPYC1_RS01135	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS01145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS01150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS01155	COG0383	alpha-mannosidase activity
PPYC1_RS01160	COG3711	transcriptional antiterminator
PPYC1_RS01160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS01170	COG1595	DNA-templated transcription, initiation
PPYC1_RS01180	COG3250	beta-galactosidase activity
PPYC1_RS01200	COG2972	Histidine kinase
PPYC1_RS01205	COG2207	Transcriptional regulator
PPYC1_RS01205	COG4753	response regulator
PPYC1_RS01210	COG2271	Major facilitator Superfamily
PPYC1_RS01215	COG0800	Aldolase
PPYC1_RS01220	COG1414	Transcriptional regulator
PPYC1_RS01230	COG0572	uridine kinase
PPYC1_RS01250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPYC1_RS01255	COG4715	Zinc finger, swim domain protein
PPYC1_RS01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPYC1_RS01285	COG1554	hydrolase, family 65, central catalytic
PPYC1_RS01290	COG1609	Transcriptional regulator
PPYC1_RS01295	COG2190	(PTS) system
PPYC1_RS01295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS01295	COG1263	PTS System
PPYC1_RS01315	COG1846	Transcriptional regulator
PPYC1_RS01320	COG0784	Response regulator, receiver
PPYC1_RS01325	COG4191	Histidine kinase
PPYC1_RS01350	COG0601	transmembrane transport
PPYC1_RS01355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS01360	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS01365	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS01380	COG3480	Lon protease (S16) C-terminal proteolytic domain
PPYC1_RS01400	COG1653	transport
PPYC1_RS01405	COG1175	transmembrane transport
PPYC1_RS01410	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS01415	COG2207	Transcriptional regulator
PPYC1_RS01415	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS01420	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS01425	COG3338	carbonate dehydratase activity
PPYC1_RS01435	COG1733	regulation of RNA biosynthetic process
PPYC1_RS01440	COG2814	Major facilitator Superfamily
PPYC1_RS01445	COG0656	L-ascorbic acid biosynthetic process
PPYC1_RS01450	COG1609	Transcriptional regulator
PPYC1_RS01455	COG1621	beta-fructofuranosidase activity
PPYC1_RS01495	COG0697	spore germination
PPYC1_RS01500	COG3152	Membrane
PPYC1_RS01505	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS01510	COG1278	Cold shock
PPYC1_RS01520	COG2267	carboxylic ester hydrolase activity
PPYC1_RS01540	COG1725	Transcriptional regulator
PPYC1_RS01545	COG1131	(ABC) transporter
PPYC1_RS01570	COG1609	Transcriptional regulator
PPYC1_RS01575	COG3459	Glycosyltransferase 36 associated
PPYC1_RS01585	COG1653	transport
PPYC1_RS01590	COG1175	transmembrane transport
PPYC1_RS01595	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS01600	COG0535	radical SAM domain protein
PPYC1_RS01605	COG1131	(ABC) transporter
PPYC1_RS01635	COG0326	Molecular chaperone. Has ATPase activity
PPYC1_RS01645	COG0584	glycerophosphoryl diester phosphodiesterase
PPYC1_RS01655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPYC1_RS01665	COG0463	Glycosyl transferase, family 2
PPYC1_RS01670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PPYC1_RS01675	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS01680	COG5002	protein histidine kinase activity
PPYC1_RS01685	COG1404	Belongs to the peptidase S8 family
PPYC1_RS01695	COG0657	acetylesterase activity
PPYC1_RS01700	COG1846	Transcriptional regulator
PPYC1_RS01705	COG1793	dna ligase
PPYC1_RS01715	COG2322	membrane
PPYC1_RS01730	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS01735	COG3291	Pkd domain containing protein
PPYC1_RS01735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PPYC1_RS01745	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PPYC1_RS01750	COG1737	Transcriptional regulator
PPYC1_RS01755	COG1940	carbohydrate kinase activity
PPYC1_RS01760	COG1233	COG1233 Phytoene dehydrogenase and related
PPYC1_RS01885	COG4585	Histidine kinase
PPYC1_RS01890	COG2197	response regulator
PPYC1_RS01900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPYC1_RS01925	COG1175	transmembrane transport
PPYC1_RS01935	COG2972	Histidine kinase
PPYC1_RS01940	COG2207	Transcriptional regulator
PPYC1_RS01940	COG4753	response regulator
PPYC1_RS01945	COG0583	DNA-binding transcription factor activity
PPYC1_RS01950	COG0163	prenyltransferase activity
PPYC1_RS01955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPYC1_RS01975	COG4932	domain protein
PPYC1_RS01975	COG5492	domain, Protein
PPYC1_RS01980	COG1760	l-serine dehydratase
PPYC1_RS01985	COG1760	l-serine dehydratase
PPYC1_RS02000	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS02005	COG0601	transmembrane transport
PPYC1_RS02025	COG0765	amino acid transport
PPYC1_RS02030	COG0765	amino acid transport
PPYC1_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS02060	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS02060	COG2207	Transcriptional regulator
PPYC1_RS02065	COG2733	membrane
PPYC1_RS02075	COG0778	Nitroreductase
PPYC1_RS02080	COG1733	regulation of RNA biosynthetic process
PPYC1_RS02090	COG4549	nuclear export factor GLE1
PPYC1_RS02095	COG2372	response to copper ion
PPYC1_RS02095	COG1276	copper resistance
PPYC1_RS02100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
PPYC1_RS02100	COG2199	diguanylate cyclase activity
PPYC1_RS02110	COG2814	Major facilitator Superfamily
PPYC1_RS02120	COG1595	DNA-templated transcription, initiation
PPYC1_RS02135	COG2608	mercury ion transmembrane transporter activity
PPYC1_RS02140	COG2217	Heavy metal translocating P-type atpase
PPYC1_RS02150	COG0778	Nitroreductase
PPYC1_RS02155	COG0084	hydrolase, TatD family'
PPYC1_RS02160	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PPYC1_RS02165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPYC1_RS02175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPYC1_RS02180	COG3871	stress protein (general stress protein 26)
PPYC1_RS02185	COG0737	Belongs to the 5'-nucleotidase family
PPYC1_RS02195	COG0604	alcohol dehydrogenase
PPYC1_RS02205	COG4221	oxidoreductase activity
PPYC1_RS02215	COG0366	Alpha amylase catalytic
PPYC1_RS02220	COG0560	Phosphoserine phosphatase
PPYC1_RS02230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPYC1_RS02235	COG2011	ABC-type metal ion transport system permease component
PPYC1_RS02240	COG0789	Transcriptional regulator
PPYC1_RS02245	COG0667	Aldo Keto reductase
PPYC1_RS02255	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS02255	COG2972	Histidine kinase
PPYC1_RS02260	COG3279	Response regulator of the LytR AlgR family
PPYC1_RS02265	COG0789	Transcriptional regulator
PPYC1_RS02280	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS02285	COG2205	protein histidine kinase activity
PPYC1_RS02315	COG0515	serine threonine protein kinase
PPYC1_RS02325	COG1070	Carbohydrate kinase
PPYC1_RS02340	COG0024	Methionine aminopeptidase
PPYC1_RS02345	COG4846	Membrane protein involved in cytochrome C biogenesis
PPYC1_RS02350	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PPYC1_RS02355	COG0778	Nitroreductase
PPYC1_RS02360	COG0392	lysyltransferase activity
PPYC1_RS02360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PPYC1_RS02370	COG2814	Major facilitator Superfamily
PPYC1_RS02375	COG2706	6-phosphogluconolactonase activity
PPYC1_RS02395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PPYC1_RS02395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PPYC1_RS02405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PPYC1_RS02410	COG0840	transmembrane signaling receptor activity
PPYC1_RS02415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPYC1_RS02420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPYC1_RS02425	COG0011	TIGRFAM Protein of
PPYC1_RS02440	COG2814	Major facilitator Superfamily
PPYC1_RS02445	COG0789	Transcriptional regulator
PPYC1_RS02445	COG4978	Transcriptional regulator
PPYC1_RS02485	COG2267	carboxylic ester hydrolase activity
PPYC1_RS02490	COG0662	Cupin 2, conserved barrel domain protein
PPYC1_RS02495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS02505	COG0412	Dienelactone hydrolase
PPYC1_RS02510	COG0640	Transcriptional regulator
PPYC1_RS02515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PPYC1_RS02540	COG2770	Histidine kinase
PPYC1_RS02540	COG3437	response regulator, receiver
PPYC1_RS02545	COG5002	protein histidine kinase activity
PPYC1_RS02545	COG2205	protein histidine kinase activity
PPYC1_RS02545	COG0784	Response regulator, receiver
PPYC1_RS02550	COG0702	epimerase
PPYC1_RS02565	COG0251	oxidation-reduction process
PPYC1_RS02570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPYC1_RS02580	COG0385	Bile acid
PPYC1_RS02585	COG1902	pentaerythritol trinitrate reductase activity
PPYC1_RS02590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS02595	COG2207	Transcriptional regulator
PPYC1_RS02595	COG4753	response regulator
PPYC1_RS02600	COG2972	Histidine kinase
PPYC1_RS02630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPYC1_RS02640	COG1876	peptidase activity
PPYC1_RS02655	COG0754	glutathionylspermidine amidase activity
PPYC1_RS02660	COG3766	membrane
PPYC1_RS02665	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS02675	COG2814	Major facilitator Superfamily
PPYC1_RS02680	COG1846	Transcriptional regulator
PPYC1_RS02685	COG1309	transcriptional regulator
PPYC1_RS02690	COG2814	Major facilitator Superfamily
PPYC1_RS02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPYC1_RS02710	COG2357	RelA SpoT domain protein
PPYC1_RS02715	COG1854	S-ribosylhomocysteine lyase activity
PPYC1_RS02720	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS02725	COG1464	Belongs to the NlpA lipoprotein family
PPYC1_RS02730	COG2207	Transcriptional regulator
PPYC1_RS02740	COG2207	Transcriptional regulator
PPYC1_RS02745	COG0697	spore germination
PPYC1_RS02750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPYC1_RS02755	COG0210	DNA helicase
PPYC1_RS02785	COG1970	mechanosensitive ion channel activity
PPYC1_RS02790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPYC1_RS02815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PPYC1_RS02825	COG0024	Methionine aminopeptidase
PPYC1_RS02860	COG1131	(ABC) transporter
PPYC1_RS02865	COG4152	abc transporter atp-binding protein
PPYC1_RS02870	COG1668	transmembrane transport
PPYC1_RS02905	COG2267	carboxylic ester hydrolase activity
PPYC1_RS02910	COG2814	Major facilitator Superfamily
PPYC1_RS02935	COG0385	Bile acid
PPYC1_RS02945	COG0457	Tetratricopeptide repeat
PPYC1_RS02970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PPYC1_RS02975	COG3250	beta-galactosidase activity
PPYC1_RS03015	COG0738	Major facilitator superfamily
PPYC1_RS03020	COG0110	maltose O-acetyltransferase activity
PPYC1_RS03025	COG1396	sequence-specific DNA binding
PPYC1_RS03035	COG0366	Alpha amylase catalytic
PPYC1_RS03040	COG1263	PTS System
PPYC1_RS03040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS03045	COG2188	Transcriptional regulator
PPYC1_RS03055	COG0531	amino acid
PPYC1_RS03060	COG0697	spore germination
PPYC1_RS03065	COG1609	Transcriptional regulator
PPYC1_RS03070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPYC1_RS03075	COG0698	ribose 5-phosphate isomerase
PPYC1_RS03095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS03100	COG2146	nitrite reductase [NAD(P)H] activity
PPYC1_RS03110	COG3693	PFAM glycoside hydrolase, family 10
PPYC1_RS03120	COG0697	spore germination
PPYC1_RS03125	COG0531	amino acid
PPYC1_RS03135	COG1695	Transcriptional regulator
PPYC1_RS03140	COG3479	Phenolic acid decarboxylase
PPYC1_RS03150	COG1733	regulation of RNA biosynthetic process
PPYC1_RS03160	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS03165	COG5002	protein histidine kinase activity
PPYC1_RS03170	COG1183	phosphatidylcholine synthase activity
PPYC1_RS03175	COG0586	Pfam SNARE associated Golgi protein
PPYC1_RS03180	COG3223	Belongs to the PsiE family
PPYC1_RS03185	COG0628	permease
PPYC1_RS03200	COG2315	Protein conserved in bacteria
PPYC1_RS03205	COG0778	Nitroreductase
PPYC1_RS03210	COG0346	lactoylglutathione lyase activity
PPYC1_RS03220	COG3173	Aminoglycoside phosphotransferase
PPYC1_RS03240	COG1874	Beta-galactosidase
PPYC1_RS03245	COG2972	Histidine kinase
PPYC1_RS03250	COG4753	response regulator
PPYC1_RS03250	COG2207	Transcriptional regulator
PPYC1_RS03305	COG0789	Transcriptional regulator
PPYC1_RS03310	COG2814	Major facilitator Superfamily
PPYC1_RS03315	COG0589	response to stress
PPYC1_RS03320	COG1012	belongs to the aldehyde dehydrogenase family
PPYC1_RS03340	COG2378	regulation of single-species biofilm formation
PPYC1_RS03345	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS03360	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS03370	COG0789	Transcriptional regulator
PPYC1_RS03395	COG1956	GAF domain-containing protein
PPYC1_RS03405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS03415	COG4721	ABC-type cobalt transport system, permease component
PPYC1_RS03420	COG1122	ATPase activity
PPYC1_RS03425	COG0477	Major facilitator Superfamily
PPYC1_RS03430	COG1621	beta-fructofuranosidase activity
PPYC1_RS03435	COG1621	beta-fructofuranosidase activity
PPYC1_RS03440	COG1846	Transcriptional regulator
PPYC1_RS03450	COG1113	amino acid transport
PPYC1_RS03455	COG1280	lysine exporter protein (LysE YggA)
PPYC1_RS03460	COG2222	sugar isomerase
PPYC1_RS03465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPYC1_RS03470	COG2188	Transcriptional regulator
PPYC1_RS03475	COG1228	amidohydrolase
PPYC1_RS03480	COG1288	antiporter activity
PPYC1_RS03485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PPYC1_RS03490	COG2081	HI0933 family
PPYC1_RS03495	COG5002	protein histidine kinase activity
PPYC1_RS03505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PPYC1_RS03525	COG1454	alcohol dehydrogenase
PPYC1_RS03530	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS03530	COG2207	Transcriptional regulator
PPYC1_RS03535	COG2318	DinB family
PPYC1_RS03545	COG0456	acetyltransferase
PPYC1_RS03555	COG0328	RNA-DNA hybrid ribonuclease activity
PPYC1_RS03560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PPYC1_RS03570	COG0302	gtp cyclohydrolase
PPYC1_RS03575	COG0095	Lipoate-protein ligase
PPYC1_RS03580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PPYC1_RS03590	COG1414	Transcriptional regulator
PPYC1_RS03595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PPYC1_RS03600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS03605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PPYC1_RS03625	COG4294	response to UV
PPYC1_RS03630	COG0483	inositol monophosphate 1-phosphatase activity
PPYC1_RS03640	COG2972	Histidine kinase
PPYC1_RS03645	COG4753	response regulator
PPYC1_RS03645	COG2207	Transcriptional regulator
PPYC1_RS03650	COG1653	transport
PPYC1_RS03655	COG1175	transmembrane transport
PPYC1_RS03660	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS03665	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS03670	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PPYC1_RS03680	COG0697	spore germination
PPYC1_RS03685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPYC1_RS03690	COG1316	TRANSCRIPTIONal
PPYC1_RS03695	COG4555	ABC transporter
PPYC1_RS03710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PPYC1_RS03735	COG0697	spore germination
PPYC1_RS03740	COG0586	Pfam SNARE associated Golgi protein
PPYC1_RS03745	COG0519	Catalyzes the synthesis of GMP from XMP
PPYC1_RS03745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PPYC1_RS03750	COG3340	Belongs to the peptidase S51 family
PPYC1_RS03760	COG0583	DNA-binding transcription factor activity
PPYC1_RS03770	COG1846	Transcriptional regulator
PPYC1_RS03775	COG0604	alcohol dehydrogenase
PPYC1_RS03785	COG2252	PERMEase
PPYC1_RS03805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPYC1_RS03815	COG0252	asparaginase activity
PPYC1_RS03825	COG3326	Membrane
PPYC1_RS03830	COG0589	response to stress
PPYC1_RS03835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PPYC1_RS03840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PPYC1_RS03845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PPYC1_RS03855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PPYC1_RS03860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPYC1_RS03865	COG0047	phosphoribosylformylglycinamidine synthase activity
PPYC1_RS03870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PPYC1_RS03875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PPYC1_RS03885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PPYC1_RS03890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PPYC1_RS03900	COG0151	Belongs to the GarS family
PPYC1_RS03915	COG1309	transcriptional regulator
PPYC1_RS03925	COG1309	transcriptional regulator
PPYC1_RS03930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS03935	COG0765	amino acid transport
PPYC1_RS03940	COG1126	abc transporter atp-binding protein
PPYC1_RS03955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS03960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS03965	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PPYC1_RS03975	COG3290	protein histidine kinase activity
PPYC1_RS03980	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PPYC1_RS03985	COG0656	L-ascorbic acid biosynthetic process
PPYC1_RS03995	COG0640	Transcriptional regulator
PPYC1_RS04000	COG0400	carboxylic ester hydrolase activity
PPYC1_RS04010	COG1653	transport
PPYC1_RS04015	COG1175	transmembrane transport
PPYC1_RS04020	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS04025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PPYC1_RS04030	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS04035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS04040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS04065	COG3384	dioxygenase
PPYC1_RS04080	COG1470	cell adhesion involved in biofilm formation
PPYC1_RS04085	COG1392	Phosphate transport regulator
PPYC1_RS04090	COG0306	phosphate transporter
PPYC1_RS04095	COG0765	amino acid transport
PPYC1_RS04110	COG0598	Magnesium transport protein CorA
PPYC1_RS04120	COG4496	protein, YerC YecD
PPYC1_RS04130	COG1597	lipid kinase activity
PPYC1_RS04135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PPYC1_RS04150	COG0326	Molecular chaperone. Has ATPase activity
PPYC1_RS04155	COG1192	Involved in chromosome partitioning
PPYC1_RS04160	COG1475	DNA binding
PPYC1_RS04340	COG0791	NLP P60 protein
PPYC1_RS04340	COG1388	LysM domain
PPYC1_RS04340	COG3103	Sh3 type 3 domain protein
PPYC1_RS04380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPYC1_RS04385	COG0720	synthase
PPYC1_RS04395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPYC1_RS04400	COG0514	ATP-dependent DNA helicase (RecQ)
PPYC1_RS04460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PPYC1_RS04475	COG1228	amidohydrolase
PPYC1_RS04485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PPYC1_RS04490	COG5426	von Willebrand factor, type A
PPYC1_RS04500	COG2378	regulation of single-species biofilm formation
PPYC1_RS04510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PPYC1_RS04555	COG1113	amino acid transport
PPYC1_RS04580	COG1733	regulation of RNA biosynthetic process
PPYC1_RS04585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS04605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPYC1_RS04610	COG3239	Fatty acid desaturase
PPYC1_RS04615	COG4585	Histidine kinase
PPYC1_RS04620	COG2197	response regulator
PPYC1_RS04625	COG1428	Deoxynucleoside kinase
PPYC1_RS04630	COG1428	Deoxynucleoside kinase
PPYC1_RS04635	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS04645	COG2011	ABC-type metal ion transport system permease component
PPYC1_RS04655	COG1473	amidohydrolase
PPYC1_RS04675	COG2814	Major facilitator Superfamily
PPYC1_RS04680	COG0583	DNA-binding transcription factor activity
PPYC1_RS04685	COG2814	Major facilitator Superfamily
PPYC1_RS04690	COG0710	3-dehydroquinate dehydratase activity
PPYC1_RS04695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PPYC1_RS04720	COG2814	Major facilitator Superfamily
PPYC1_RS04725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPYC1_RS04730	COG4989	oxidoreductase activity
PPYC1_RS04750	COG3541	Predicted nucleotidyltransferase
PPYC1_RS04760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PPYC1_RS04775	COG4172	Belongs to the ABC transporter superfamily
PPYC1_RS04785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPYC1_RS04790	COG2011	ABC-type metal ion transport system permease component
PPYC1_RS04815	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS04820	COG1472	Belongs to the glycosyl hydrolase 3 family
PPYC1_RS04845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS04850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS04855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS04860	COG1120	ATPase activity
PPYC1_RS04880	COG4264	IucA IucC family
PPYC1_RS04885	COG4264	IucA IucC family
PPYC1_RS04895	COG0019	diaminopimelate decarboxylase activity
PPYC1_RS04900	COG4264	IucA IucC family
PPYC1_RS04910	COG4474	Belongs to the UPF0398 family
PPYC1_RS04915	COG3401	FG-GAP repeat protein
PPYC1_RS04935	COG2116	formate transmembrane transporter activity
PPYC1_RS04940	COG0561	phosphatase activity
PPYC1_RS04955	COG2310	stress, protein
PPYC1_RS04960	COG2310	stress, protein
PPYC1_RS04965	COG2310	stress, protein
PPYC1_RS04975	COG0861	Integral membrane protein TerC family
PPYC1_RS04990	COG1358	cellular component organization or biogenesis
PPYC1_RS05025	COG4166	transmembrane transport
PPYC1_RS05030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS05035	COG0601	transmembrane transport
PPYC1_RS05040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PPYC1_RS05045	COG0765	amino acid transport
PPYC1_RS05050	COG1126	abc transporter atp-binding protein
PPYC1_RS05060	COG1309	transcriptional regulator
PPYC1_RS05075	COG1473	amidohydrolase
PPYC1_RS05085	COG1024	Enoyl-CoA hydratase
PPYC1_RS05100	COG0534	Mate efflux family protein
PPYC1_RS05110	COG0656	L-ascorbic acid biosynthetic process
PPYC1_RS05135	COG3401	FG-GAP repeat protein
PPYC1_RS05145	COG4209	transmembrane transport
PPYC1_RS05150	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS05160	COG1621	beta-fructofuranosidase activity
PPYC1_RS05170	COG0535	radical SAM domain protein
PPYC1_RS05170	COG1433	Dinitrogenase iron-molybdenum cofactor
PPYC1_RS05175	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
PPYC1_RS05180	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPYC1_RS05190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPYC1_RS05195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
PPYC1_RS05205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPYC1_RS05215	COG1132	(ABC) transporter
PPYC1_RS05220	COG1132	(ABC) transporter
PPYC1_RS05230	COG2814	Major facilitator Superfamily
PPYC1_RS05245	COG2814	Major facilitator Superfamily
PPYC1_RS05250	COG4753	response regulator
PPYC1_RS05250	COG2207	Transcriptional regulator
PPYC1_RS05255	COG2972	Histidine kinase
PPYC1_RS05265	COG0561	phosphatase activity
PPYC1_RS05270	COG1486	melibiose metabolic process
PPYC1_RS05275	COG5297	Belongs to the glycosyl hydrolase family 6
PPYC1_RS05285	COG4999	Histidine kinase
PPYC1_RS05285	COG3850	Histidine kinase
PPYC1_RS05285	COG2205	protein histidine kinase activity
PPYC1_RS05285	COG3437	response regulator, receiver
PPYC1_RS05290	COG1725	Transcriptional regulator
PPYC1_RS05295	COG1131	(ABC) transporter
PPYC1_RS05315	COG0656	L-ascorbic acid biosynthetic process
PPYC1_RS05320	COG3663	DNA glycosylase
PPYC1_RS05325	COG0686	Belongs to the AlaDH PNT family
PPYC1_RS05355	COG1253	flavin adenine dinucleotide binding
PPYC1_RS05360	COG0840	transmembrane signaling receptor activity
PPYC1_RS05370	COG5522	Integral membrane protein (intg_mem_TP0381)
PPYC1_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS05385	COG1285	pathogenesis
PPYC1_RS05390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PPYC1_RS05410	COG0697	spore germination
PPYC1_RS05415	COG1378	Sugar-specific transcriptional regulator TrmB
PPYC1_RS05425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPYC1_RS05425	COG1605	Chorismate mutase
PPYC1_RS05445	COG2205	protein histidine kinase activity
PPYC1_RS05510	COG2972	Histidine kinase
PPYC1_RS05515	COG2197	response regulator
PPYC1_RS05520	COG1151	hydroxylamine reductase activity
PPYC1_RS05540	COG4213	ABC transporter substrate-binding protein
PPYC1_RS05550	COG4214	carbohydrate transport
PPYC1_RS05555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PPYC1_RS05560	COG1522	sequence-specific DNA binding
PPYC1_RS05570	COG2217	Heavy metal translocating P-type atpase
PPYC1_RS05575	COG2223	nitrite transmembrane transporter activity
PPYC1_RS05600	COG1621	beta-fructofuranosidase activity
PPYC1_RS05605	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS05605	COG4977	sequence-specific DNA binding
PPYC1_RS05610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PPYC1_RS05620	COG0720	synthase
PPYC1_RS05625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PPYC1_RS05655	COG0737	Belongs to the 5'-nucleotidase family
PPYC1_RS05665	COG1396	sequence-specific DNA binding
PPYC1_RS05705	COG2823	Periplasmic or secreted lipoprotein
PPYC1_RS05705	COG1652	LysM domain
PPYC1_RS05725	COG3299	homolog of phage Mu protein gp47
PPYC1_RS05750	COG4824	toxin secretion phage lysis holin
PPYC1_RS05755	COG3757	hydrolase, family 25
PPYC1_RS05790	COG4221	oxidoreductase activity
PPYC1_RS05790	COG4221	oxidoreductase activity
PPYC1_RS05790	COG3321	synthase
PPYC1_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS05790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS05790	COG3321	synthase
PPYC1_RS05790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS05800	COG0436	Aminotransferase
PPYC1_RS05810	COG0300	oxidoreductase activity
PPYC1_RS05810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS05810	COG3321	synthase
PPYC1_RS05810	COG4221	oxidoreductase activity
PPYC1_RS05840	COG0747	negative chemotaxis
PPYC1_RS05845	COG0601	transmembrane transport
PPYC1_RS05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS05855	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PPYC1_RS05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS05875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PPYC1_RS05880	COG3773	Cell wall hydrolase
PPYC1_RS05890	COG0067	glutamate synthase
PPYC1_RS05890	COG0070	glutamate synthase
PPYC1_RS05890	COG0069	glutamate synthase activity
PPYC1_RS05900	COG2197	response regulator
PPYC1_RS05905	COG3944	biosynthesis protein
PPYC1_RS05910	COG0489	protein tyrosine kinase activity
PPYC1_RS05915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPYC1_RS05920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPYC1_RS05925	COG1216	Glycosyl transferase, family 2
PPYC1_RS05935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PPYC1_RS05955	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS05960	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS05970	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PPYC1_RS05975	COG0662	Cupin 2, conserved barrel domain protein
PPYC1_RS05975	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPYC1_RS05980	COG2133	pyrroloquinoline quinone binding
PPYC1_RS05980	COG5183	chlorophyll binding
PPYC1_RS06000	COG3944	biosynthesis protein
PPYC1_RS06005	COG0489	protein tyrosine kinase activity
PPYC1_RS06010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PPYC1_RS06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPYC1_RS06045	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PPYC1_RS06050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PPYC1_RS06065	COG1131	(ABC) transporter
PPYC1_RS06070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PPYC1_RS06075	COG0628	permease
PPYC1_RS06085	COG0739	heme binding
PPYC1_RS06090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPYC1_RS06095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS06110	COG0367	asparagine synthase
PPYC1_RS06135	COG1132	(ABC) transporter
PPYC1_RS06140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PPYC1_RS06165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PPYC1_RS06170	COG4689	acetoacetate decarboxylase
PPYC1_RS06175	COG0183	Belongs to the thiolase family
PPYC1_RS06185	COG0802	atpase or kinase
PPYC1_RS06190	COG1214	PFAM Peptidase M22, glycoprotease
PPYC1_RS06195	COG0456	acetyltransferase
PPYC1_RS06200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PPYC1_RS06205	COG0488	(ABC) transporter
PPYC1_RS06210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PPYC1_RS06215	COG0315	cyclic pyranopterin monophosphate synthase activity
PPYC1_RS06220	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPYC1_RS06225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PPYC1_RS06230	COG0805	protein transport
PPYC1_RS06235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PPYC1_RS06240	COG0459	protein refolding
PPYC1_RS06295	COG0789	Transcriptional regulator
PPYC1_RS06365	COG1175	transmembrane transport
PPYC1_RS06370	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS06375	COG1653	transport
PPYC1_RS06380	COG1309	transcriptional regulator
PPYC1_RS06395	COG2113	Glycine betaine
PPYC1_RS06400	COG0517	IMP dehydrogenase activity
PPYC1_RS06400	COG4175	Glycine betaine
PPYC1_RS06405	COG1510	regulation of RNA biosynthetic process
PPYC1_RS06410	COG2272	Belongs to the type-B carboxylesterase lipase family
PPYC1_RS06430	COG1131	(ABC) transporter
PPYC1_RS06435	COG2205	protein histidine kinase activity
PPYC1_RS06440	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS06455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PPYC1_RS06460	COG0662	Cupin 2, conserved barrel domain protein
PPYC1_RS06460	COG2207	Transcriptional regulator
PPYC1_RS06470	COG1280	lysine exporter protein (LysE YggA)
PPYC1_RS06475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PPYC1_RS06480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PPYC1_RS06485	COG0864	Transcriptional regulator
PPYC1_RS06490	COG2337	Toxic component of a toxin-antitoxin (TA) module
PPYC1_RS06495	COG2183	response to ionizing radiation
PPYC1_RS06515	COG0561	phosphatase activity
PPYC1_RS06520	COG1349	DNA-binding transcription factor activity
PPYC1_RS06560	COG0830	nickel cation binding
PPYC1_RS06570	COG0386	Belongs to the glutathione peroxidase family
PPYC1_RS06585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PPYC1_RS06600	COG2814	Major facilitator Superfamily
PPYC1_RS06610	COG1045	serine acetyltransferase
PPYC1_RS06635	COG1914	H( )-stimulated, divalent metal cation uptake system
PPYC1_RS06645	COG1764	response to oxidative stress
PPYC1_RS06655	COG3011	Protein conserved in bacteria
PPYC1_RS06665	COG0803	Belongs to the bacterial solute-binding protein 9 family
PPYC1_RS06670	COG1121	(ABC) transporter
PPYC1_RS06675	COG1321	iron dependent repressor
PPYC1_RS06675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPYC1_RS06680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPYC1_RS06685	COG2205	protein histidine kinase activity
PPYC1_RS06735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PPYC1_RS06760	COG1090	epimerase
PPYC1_RS06765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPYC1_RS06770	COG0788	formyltetrahydrofolate deformylase activity
PPYC1_RS06790	COG0166	Belongs to the GPI family
PPYC1_RS06795	COG1739	Uncharacterized protein family UPF0029
PPYC1_RS06805	COG0432	Pfam Uncharacterised protein family UPF0047
PPYC1_RS06810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PPYC1_RS06815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPYC1_RS06815	COG0321	lipoyl(octanoyl) transferase activity
PPYC1_RS06820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS06830	COG0561	phosphatase activity
PPYC1_RS06835	COG0095	Lipoate-protein ligase
PPYC1_RS06840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPYC1_RS06850	COG0588	phosphoglycerate mutase activity
PPYC1_RS06855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS06860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS06865	COG1120	ATPase activity
PPYC1_RS06870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PPYC1_RS06875	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
PPYC1_RS06880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PPYC1_RS06885	COG1492	cobalamin metabolic process
PPYC1_RS06890	COG0840	transmembrane signaling receptor activity
PPYC1_RS06895	COG2190	(PTS) system
PPYC1_RS06895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS06895	COG1263	PTS System
PPYC1_RS06900	COG3711	transcriptional antiterminator
PPYC1_RS06905	COG1263	PTS System
PPYC1_RS06905	COG2190	(PTS) system
PPYC1_RS06905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS06915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PPYC1_RS06920	COG0006	proline dipeptidase activity
PPYC1_RS06930	COG1247	-acetyltransferase
PPYC1_RS06935	COG3610	response to peptide
PPYC1_RS06940	COG2966	Psort location CytoplasmicMembrane, score
PPYC1_RS06955	COG2112	serine threonine protein kinase
PPYC1_RS06965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PPYC1_RS06985	COG0514	ATP-dependent DNA helicase (RecQ)
PPYC1_RS06995	COG1785	Belongs to the alkaline phosphatase family
PPYC1_RS07000	COG0586	Pfam SNARE associated Golgi protein
PPYC1_RS07040	COG0667	Aldo Keto reductase
PPYC1_RS07080	COG1418	mRNA catabolic process
PPYC1_RS07125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS07130	COG2205	protein histidine kinase activity
PPYC1_RS07135	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS07150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS07215	COG2814	Major facilitator Superfamily
PPYC1_RS07220	COG0567	Dehydrogenase, E1 component
PPYC1_RS07225	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPYC1_RS07230	COG2318	DinB family
PPYC1_RS07240	COG1482	cell wall glycoprotein biosynthetic process
PPYC1_RS07245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PPYC1_RS07250	COG1242	4 iron, 4 sulfur cluster binding
PPYC1_RS07260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PPYC1_RS07265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPYC1_RS07270	COG0671	phosphoesterase, PA-phosphatase related
PPYC1_RS07275	COG1215	transferase activity, transferring glycosyl groups
PPYC1_RS07285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PPYC1_RS07290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PPYC1_RS07295	COG1744	ABC transporter substrate-binding protein PnrA-like
PPYC1_RS07300	COG3845	ABC transporter
PPYC1_RS07305	COG4603	Belongs to the binding-protein-dependent transport system permease family
PPYC1_RS07310	COG1079	Belongs to the binding-protein-dependent transport system permease family
PPYC1_RS07325	COG0028	Belongs to the TPP enzyme family
PPYC1_RS07330	COG0440	acetolactate synthase activity
PPYC1_RS07335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PPYC1_RS07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPYC1_RS07350	COG0450	alkyl hydroperoxide reductase
PPYC1_RS07360	COG4191	Histidine kinase
PPYC1_RS07385	COG0488	(ABC) transporter
PPYC1_RS07390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PPYC1_RS07400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PPYC1_RS07410	COG1193	negative regulation of DNA recombination
PPYC1_RS07415	COG3766	membrane
PPYC1_RS07425	COG0477	Major facilitator Superfamily
PPYC1_RS07445	COG1522	sequence-specific DNA binding
PPYC1_RS07450	COG0436	Aminotransferase
PPYC1_RS07465	COG2096	Adenosyltransferase
PPYC1_RS07470	COG0564	pseudouridine synthase activity
PPYC1_RS07475	COG1393	Belongs to the ArsC family
PPYC1_RS07480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PPYC1_RS07485	COG1940	carbohydrate kinase activity
PPYC1_RS07495	COG0598	Magnesium transport protein CorA
PPYC1_RS07500	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PPYC1_RS07505	COG0626	cystathionine gamma-synthase activity
PPYC1_RS07510	COG0626	cystathionine gamma-synthase activity
PPYC1_RS07515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPYC1_RS07520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS07525	COG0475	glutathione-regulated potassium exporter activity
PPYC1_RS07530	COG0490	domain, Protein
PPYC1_RS07545	COG3584	3D domain protein
PPYC1_RS07555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPYC1_RS07560	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS07565	COG5002	protein histidine kinase activity
PPYC1_RS07565	COG3850	Histidine kinase
PPYC1_RS07570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PPYC1_RS07575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PPYC1_RS07580	COG0174	glutamine synthetase
PPYC1_RS07590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PPYC1_RS07595	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS07610	COG2197	response regulator
PPYC1_RS07615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS07625	COG2766	serine protein kinase
PPYC1_RS07630	COG3290	protein histidine kinase activity
PPYC1_RS07630	COG0840	transmembrane signaling receptor activity
PPYC1_RS07645	COG3212	peptidase
PPYC1_RS07655	COG3850	Histidine kinase
PPYC1_RS07655	COG5002	protein histidine kinase activity
PPYC1_RS07660	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS07665	COG4126	flavin adenine dinucleotide binding
PPYC1_RS07680	COG2508	Transcriptional regulator
PPYC1_RS07685	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS07690	COG5002	protein histidine kinase activity
PPYC1_RS07705	COG2719	SpoVR family
PPYC1_RS07710	COG2718	Belongs to the UPF0229 family
PPYC1_RS07715	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS07720	COG2205	protein histidine kinase activity
PPYC1_RS07790	COG1396	sequence-specific DNA binding
PPYC1_RS07795	COG1607	acyl-coa hydrolase
PPYC1_RS07810	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PPYC1_RS07820	COG1307	EDD domain protein, DegV family
PPYC1_RS07830	COG2363	Small membrane protein
PPYC1_RS07845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PPYC1_RS07860	COG0640	Transcriptional regulator
PPYC1_RS07865	COG2814	Major facilitator Superfamily
PPYC1_RS07880	COG0456	acetyltransferase
PPYC1_RS08120	COG0582	viral genome integration into host DNA
PPYC1_RS08135	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PPYC1_RS08140	COG0783	Belongs to the Dps family
PPYC1_RS08145	COG0396	ATPase activity
PPYC1_RS08150	COG0719	Fe-S assembly protein
PPYC1_RS08155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPYC1_RS08160	COG0822	iron-sulfur transferase activity
PPYC1_RS08165	COG0719	Fe-S assembly protein
PPYC1_RS08180	COG0737	Belongs to the 5'-nucleotidase family
PPYC1_RS08190	COG0535	radical SAM domain protein
PPYC1_RS08195	COG1253	flavin adenine dinucleotide binding
PPYC1_RS08210	COG3546	catalase activity
PPYC1_RS08215	COG0463	Glycosyl transferase, family 2
PPYC1_RS08220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PPYC1_RS08230	COG0546	phosphoglycolate phosphatase activity
PPYC1_RS08235	COG0189	ligase activity
PPYC1_RS08250	COG0189	ligase activity
PPYC1_RS08255	COG0189	ligase activity
PPYC1_RS08260	COG0189	ligase activity
PPYC1_RS08265	COG3679	Belongs to the UPF0342 family
PPYC1_RS08275	COG4109	DRTGG domain
PPYC1_RS08295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPYC1_RS08305	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PPYC1_RS08310	COG0825	malonyl-CoA metabolic process
PPYC1_RS08315	COG0469	pyruvate kinase activity
PPYC1_RS08320	COG0583	DNA-binding transcription factor activity
PPYC1_RS08325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PPYC1_RS08330	COG0573	inorganic phosphate transmembrane transporter activity
PPYC1_RS08335	COG0581	inorganic phosphate transmembrane transporter activity
PPYC1_RS08340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPYC1_RS08350	COG0824	Thioesterase
PPYC1_RS08355	COG3030	protein affecting phage T7 exclusion by the F plasmid
PPYC1_RS08360	COG0628	permease
PPYC1_RS08365	COG0372	Belongs to the citrate synthase family
PPYC1_RS08370	COG0538	isocitrate dehydrogenase activity
PPYC1_RS08375	COG0039	L-malate dehydrogenase activity
PPYC1_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS08390	COG5002	protein histidine kinase activity
PPYC1_RS08395	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS08400	COG0840	transmembrane signaling receptor activity
PPYC1_RS08405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPYC1_RS08410	COG0704	Plays a role in the regulation of phosphate uptake
PPYC1_RS08420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPYC1_RS08425	COG1971	Probably functions as a manganese efflux pump
PPYC1_RS08430	COG0237	dephospho-CoA kinase activity
PPYC1_RS08445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PPYC1_RS08460	COG5566	PFAM Mor transcription activator
PPYC1_RS08505	COG0840	transmembrane signaling receptor activity
PPYC1_RS08520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPYC1_RS08535	COG4122	O-methyltransferase activity
PPYC1_RS08540	COG1349	DNA-binding transcription factor activity
PPYC1_RS08545	COG1105	Belongs to the carbohydrate kinase PfkB family
PPYC1_RS08550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS08550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS08550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS08555	COG0583	DNA-binding transcription factor activity
PPYC1_RS08560	COG1942	4-Oxalocrotonate Tautomerase
PPYC1_RS08575	COG2084	Dehydrogenase
PPYC1_RS08590	COG3711	transcriptional antiterminator
PPYC1_RS08595	COG2190	(PTS) system
PPYC1_RS08595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS08595	COG1263	PTS System
PPYC1_RS08600	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS08605	COG0583	DNA-binding transcription factor activity
PPYC1_RS08610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PPYC1_RS08660	COG0326	Molecular chaperone. Has ATPase activity
PPYC1_RS08720	COG3279	Response regulator of the LytR AlgR family
PPYC1_RS08725	COG2972	Histidine kinase
PPYC1_RS08740	COG4209	transmembrane transport
PPYC1_RS08745	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS08750	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS08760	COG5520	Belongs to the glycosyl hydrolase 30 family
PPYC1_RS08765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPYC1_RS08775	COG0371	Dehydrogenase
PPYC1_RS08785	COG0235	Class ii aldolase
PPYC1_RS08790	COG1069	ribulokinase activity
PPYC1_RS08805	COG0726	polysaccharide deacetylase
PPYC1_RS08810	COG4824	toxin secretion phage lysis holin
PPYC1_RS08820	COG2445	Protein of unknown function DUF86
PPYC1_RS08830	COG4980	gas vesicle protein
PPYC1_RS08835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPYC1_RS08855	COG4844	belongs to the
PPYC1_RS08865	COG1368	sulfuric ester hydrolase activity
PPYC1_RS08870	COG0116	Belongs to the methyltransferase superfamily
PPYC1_RS08875	COG4122	O-methyltransferase activity
PPYC1_RS08880	COG2814	Major facilitator Superfamily
PPYC1_RS08885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PPYC1_RS08890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PPYC1_RS08895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PPYC1_RS08900	COG2843	Capsule synthesis protein
PPYC1_RS08905	COG0584	glycerophosphoryl diester phosphodiesterase
PPYC1_RS08920	COG1309	transcriptional regulator
PPYC1_RS08925	COG0488	(ABC) transporter
PPYC1_RS08930	COG0667	Aldo Keto reductase
PPYC1_RS08935	COG0583	DNA-binding transcription factor activity
PPYC1_RS08940	COG1363	Peptidase, m42
PPYC1_RS08945	COG5416	Lipopolysaccharide assembly protein A domain
PPYC1_RS08950	COG1164	Oligoendopeptidase f
PPYC1_RS08970	COG0534	Mate efflux family protein
PPYC1_RS08990	COG0534	Mate efflux family protein
PPYC1_RS09005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS09010	COG0513	Belongs to the DEAD box helicase family
PPYC1_RS09015	COG5578	integral membrane protein
PPYC1_RS09030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PPYC1_RS09035	COG0705	Rhomboid family
PPYC1_RS09040	COG0583	DNA-binding transcription factor activity
PPYC1_RS09045	COG2738	Putative neutral zinc metallopeptidase
PPYC1_RS09050	COG0789	Transcriptional regulator
PPYC1_RS09060	COG0004	ammonium transporteR
PPYC1_RS09070	COG2176	DNA-directed DNA polymerase activity
PPYC1_RS09080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPYC1_RS09085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPYC1_RS09095	COG1376	ErfK ybiS ycfS ynhG family protein
PPYC1_RS09100	COG0167	dihydroorotate dehydrogenase activity
PPYC1_RS09105	COG2357	RelA SpoT domain protein
PPYC1_RS09110	COG1547	Domain of unknown function (DUF309)
PPYC1_RS09120	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PPYC1_RS09120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPYC1_RS09125	COG1187	pseudouridine synthase activity
PPYC1_RS09130	COG5001	Diguanylate cyclase
PPYC1_RS09130	COG5002	protein histidine kinase activity
PPYC1_RS09130	COG3447	MASE1 domain protein
PPYC1_RS09140	COG3949	Membrane
PPYC1_RS09145	COG0586	Pfam SNARE associated Golgi protein
PPYC1_RS09150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPYC1_RS09165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PPYC1_RS09180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPYC1_RS09185	COG2861	carbohydrate metabolic process
PPYC1_RS09210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PPYC1_RS09220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPYC1_RS09225	COG0456	acetyltransferase
PPYC1_RS09230	COG2378	regulation of single-species biofilm formation
PPYC1_RS09240	COG2814	Major facilitator Superfamily
PPYC1_RS09245	COG1309	transcriptional regulator
PPYC1_RS09265	COG0436	Aminotransferase
PPYC1_RS09295	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS09300	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS09305	COG3940	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS09315	COG0702	epimerase
PPYC1_RS09320	COG2226	methyltransferase
PPYC1_RS09325	COG0456	acetyltransferase
PPYC1_RS09325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PPYC1_RS09340	COG1846	Transcriptional regulator
PPYC1_RS09350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPYC1_RS09355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PPYC1_RS09385	COG1609	Transcriptional regulator
PPYC1_RS09395	COG2207	Transcriptional regulator
PPYC1_RS09400	COG1940	carbohydrate kinase activity
PPYC1_RS09415	COG4209	transmembrane transport
PPYC1_RS09420	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS09440	COG4895	conserved protein (DUF2196)
PPYC1_RS09445	COG3647	Membrane
PPYC1_RS09450	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS09460	COG4129	membrane
PPYC1_RS09465	COG3973	AAA domain
PPYC1_RS09470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PPYC1_RS09490	COG0840	transmembrane signaling receptor activity
PPYC1_RS09495	COG2211	Major facilitator Superfamily
PPYC1_RS09500	COG1114	Component of the transport system for branched-chain amino acids
PPYC1_RS09505	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS09505	COG2207	Transcriptional regulator
PPYC1_RS09510	COG1501	Belongs to the glycosyl hydrolase 31 family
PPYC1_RS09525	COG2814	Major facilitator Superfamily
PPYC1_RS09530	COG2814	Major facilitator Superfamily
PPYC1_RS09535	COG1846	Transcriptional regulator
PPYC1_RS09540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PPYC1_RS09545	COG0517	IMP dehydrogenase activity
PPYC1_RS09555	COG0726	polysaccharide deacetylase
PPYC1_RS09575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PPYC1_RS09585	COG1846	Transcriptional regulator
PPYC1_RS09590	COG5012	cobalamin binding
PPYC1_RS09595	COG2198	Histidine kinase
PPYC1_RS09595	COG2205	protein histidine kinase activity
PPYC1_RS09595	COG0784	Response regulator, receiver
PPYC1_RS09600	COG2211	Major facilitator Superfamily
PPYC1_RS09615	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS09625	COG5646	InterPro IPR014922
PPYC1_RS09630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS09640	COG1454	alcohol dehydrogenase
PPYC1_RS09660	COG1846	Transcriptional regulator
PPYC1_RS09665	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS09670	COG0789	Transcriptional regulator
PPYC1_RS09705	COG2207	Transcriptional regulator
PPYC1_RS09710	COG0531	amino acid
PPYC1_RS09740	COG0742	ribosomal rna small subunit methyltransferase
PPYC1_RS09745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PPYC1_RS09750	COG3314	Sporulation integral membrane protein YlbJ
PPYC1_RS09755	COG3480	Lon protease (S16) C-terminal proteolytic domain
PPYC1_RS09770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PPYC1_RS09790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPYC1_RS09800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS09805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPYC1_RS09810	COG0571	ribonuclease III activity
PPYC1_RS09815	COG1196	nuclear chromosome segregation
PPYC1_RS09820	COG0552	protein localization to endoplasmic reticulum
PPYC1_RS09825	COG1272	protein, Hemolysin III
PPYC1_RS09830	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PPYC1_RS09835	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PPYC1_RS09840	COG0228	four-way junction DNA binding
PPYC1_RS09850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PPYC1_RS09855	COG0336	Belongs to the RNA methyltransferase TrmD family
PPYC1_RS09860	COG0335	large ribosomal subunit rRNA binding
PPYC1_RS09875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PPYC1_RS09890	COG0792	nuclease activity
PPYC1_RS09905	COG1764	response to oxidative stress
PPYC1_RS09910	COG1846	Transcriptional regulator
PPYC1_RS09915	COG0045	succinate-CoA ligase (ADP-forming) activity
PPYC1_RS09920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PPYC1_RS09925	COG0758	DNA mediated transformation
PPYC1_RS09930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PPYC1_RS09935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PPYC1_RS09940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PPYC1_RS09945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PPYC1_RS09950	COG1815	bacterial-type flagellum-dependent cell motility
PPYC1_RS09955	COG1558	bacterial-type flagellum-dependent cell motility
PPYC1_RS09960	COG1677	Flagellar hook-basal body complex protein FliE
PPYC1_RS09965	COG1766	The M ring may be actively involved in energy transduction
PPYC1_RS09970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPYC1_RS09980	COG1157	protein secretion by the type III secretion system
PPYC1_RS09985	COG2882	bacterial-type flagellum organization
PPYC1_RS10000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PPYC1_RS10010	COG4786	Flagellar basal body rod
PPYC1_RS10025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPYC1_RS10030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PPYC1_RS10030	COG1776	CheC inhibitor of MCP methylation
PPYC1_RS10035	COG2201	protein-glutamate methylesterase activity
PPYC1_RS10040	COG3190	flagellar
PPYC1_RS10045	COG1338	Plays a role in the flagellum-specific transport system
PPYC1_RS10050	COG1987	bacterial-type flagellum assembly
PPYC1_RS10055	COG1684	flagellar biosynthetic protein fliR
PPYC1_RS10060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPYC1_RS10065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PPYC1_RS10070	COG1419	protein localization to endoplasmic reticulum
PPYC1_RS10075	COG0455	bacterial-type flagellum organization
PPYC1_RS10080	COG2201	protein-glutamate methylesterase activity
PPYC1_RS10085	COG0643	Histidine kinase
PPYC1_RS10085	COG2198	Histidine kinase
PPYC1_RS10095	COG1776	CheC inhibitor of MCP methylation
PPYC1_RS10100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PPYC1_RS10110	COG1191	sigma factor activity
PPYC1_RS10135	COG0052	Belongs to the universal ribosomal protein uS2 family
PPYC1_RS10140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PPYC1_RS10145	COG0528	UMP kinase activity
PPYC1_RS10150	COG0233	cytoplasmic translational termination
PPYC1_RS10155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PPYC1_RS10160	COG4589	Belongs to the CDS family
PPYC1_RS10165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PPYC1_RS10170	COG0750	zinc metalloprotease
PPYC1_RS10175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PPYC1_RS10180	COG2176	DNA-directed DNA polymerase activity
PPYC1_RS10185	COG0779	Required for maturation of 30S ribosomal subunits
PPYC1_RS10190	COG0195	Participates in both transcription termination and antitermination
PPYC1_RS10200	COG1358	cellular component organization or biogenesis
PPYC1_RS10210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PPYC1_RS10215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PPYC1_RS10220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PPYC1_RS10225	COG0196	riboflavin kinase activity
PPYC1_RS10230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PPYC1_RS10235	COG1185	polyribonucleotide nucleotidyltransferase activity
PPYC1_RS10240	COG0726	polysaccharide deacetylase
PPYC1_RS10245	COG0612	Peptidase, M16
PPYC1_RS10250	COG0756	dUTP diphosphatase activity
PPYC1_RS10255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPYC1_RS10260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPYC1_RS10265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PPYC1_RS10270	COG0527	aspartate kinase activity
PPYC1_RS10275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PPYC1_RS10280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PPYC1_RS10285	COG0740	serine-type endopeptidase activity
PPYC1_RS10295	COG1674	ftsk spoiiie
PPYC1_RS10305	COG0612	Peptidase, M16
PPYC1_RS10310	COG0612	Peptidase, M16
PPYC1_RS10315	COG0300	oxidoreductase activity
PPYC1_RS10330	COG1426	Protein conserved in bacteria
PPYC1_RS10340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PPYC1_RS10345	COG1058	Belongs to the CinA family
PPYC1_RS10345	COG1546	Belongs to the CinA family
PPYC1_RS10365	COG1692	metallophosphoesterase
PPYC1_RS10370	COG2359	stage V sporulation protein S
PPYC1_RS10385	COG4869	propanediol catabolic process
PPYC1_RS10390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPYC1_RS10395	COG4550	Control of competence regulator ComK, YlbF/YmcA
PPYC1_RS10410	COG1335	isochorismatase
PPYC1_RS10415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PPYC1_RS10420	COG0521	Mo-molybdopterin cofactor biosynthetic process
PPYC1_RS10430	COG0018	arginyl-trna synthetase
PPYC1_RS10440	COG1132	(ABC) transporter
PPYC1_RS10445	COG1132	(ABC) transporter
PPYC1_RS10465	COG2707	UPF0756 membrane protein
PPYC1_RS10470	COG0492	ferredoxin-NADP+ reductase activity
PPYC1_RS10475	COG0640	Transcriptional regulator
PPYC1_RS10485	COG1376	ErfK ybiS ycfS ynhG family protein
PPYC1_RS10505	COG1674	ftsk spoiiie
PPYC1_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS10595	COG2801	Transposase and inactivated derivatives
PPYC1_RS10680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPYC1_RS10685	COG1643	Atp-dependent helicase
PPYC1_RS10705	COG0110	maltose O-acetyltransferase activity
PPYC1_RS10720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PPYC1_RS10725	COG3599	regulation of cell shape
PPYC1_RS10730	COG1959	2 iron, 2 sulfur cluster binding
PPYC1_RS10755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS10765	COG1733	regulation of RNA biosynthetic process
PPYC1_RS10770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPYC1_RS10775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PPYC1_RS10780	COG2135	peptidase activity
PPYC1_RS10785	COG0477	Major facilitator Superfamily
PPYC1_RS10790	COG1764	response to oxidative stress
PPYC1_RS10795	COG2706	6-phosphogluconolactonase activity
PPYC1_RS10810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PPYC1_RS10820	COG0346	lactoylglutathione lyase activity
PPYC1_RS10830	COG1404	Belongs to the peptidase S8 family
PPYC1_RS10840	COG3527	Alpha-acetolactate decarboxylase
PPYC1_RS10845	COG0028	Belongs to the TPP enzyme family
PPYC1_RS10855	COG1904	glucuronate isomerase
PPYC1_RS10860	COG2211	Major facilitator Superfamily
PPYC1_RS10865	COG1609	Transcriptional regulator
PPYC1_RS10870	COG0028	Belongs to the TPP enzyme family
PPYC1_RS10875	COG0246	Mannitol dehydrogenase
PPYC1_RS10880	COG2721	sulfolactate sulfo-lyase activity
PPYC1_RS10900	COG4209	transmembrane transport
PPYC1_RS10905	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS10915	COG2972	Histidine kinase
PPYC1_RS10920	COG4753	response regulator
PPYC1_RS10920	COG2207	Transcriptional regulator
PPYC1_RS10930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPYC1_RS10935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPYC1_RS10940	COG0058	SHG alpha-glucan phosphorylase activity
PPYC1_RS10960	COG0667	Aldo Keto reductase
PPYC1_RS10965	COG0697	spore germination
PPYC1_RS10970	COG0523	cobalamin synthesis protein
PPYC1_RS10975	COG0583	DNA-binding transcription factor activity
PPYC1_RS10980	COG2329	Antibiotic biosynthesis monooxygenase
PPYC1_RS10985	COG2323	membrane
PPYC1_RS10990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PPYC1_RS10995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS11000	COG0431	NADPH-dependent FMN reductase
PPYC1_RS11005	COG0583	DNA-binding transcription factor activity
PPYC1_RS11010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS11015	COG0765	amino acid transport
PPYC1_RS11020	COG0765	amino acid transport
PPYC1_RS11025	COG1126	abc transporter atp-binding protein
PPYC1_RS11030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS11035	COG1473	amidohydrolase
PPYC1_RS11055	COG0747	negative chemotaxis
PPYC1_RS11060	COG0601	transmembrane transport
PPYC1_RS11065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS11070	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS11075	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS11080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PPYC1_RS11105	COG1714	RDD family
PPYC1_RS11110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS11115	COG1199	ATP-dependent helicase activity
PPYC1_RS11130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PPYC1_RS11135	COG0626	cystathionine gamma-synthase activity
PPYC1_RS11195	COG0477	Major facilitator Superfamily
PPYC1_RS11215	COG0254	rRNA binding
PPYC1_RS11220	COG0523	cobalamin synthesis protein
PPYC1_RS11230	COG0701	Predicted permease
PPYC1_RS11235	COG0523	cobalamin synthesis protein
PPYC1_RS11240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS11250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS11255	COG1121	(ABC) transporter
PPYC1_RS11260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PPYC1_RS11265	COG0803	Belongs to the bacterial solute-binding protein 9 family
PPYC1_RS11270	COG2201	protein-glutamate methylesterase activity
PPYC1_RS11350	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PPYC1_RS11355	COG1959	2 iron, 2 sulfur cluster binding
PPYC1_RS11360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS11365	COG3347	Dehydrogenase
PPYC1_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS11370	COG4952	isomerase
PPYC1_RS11375	COG1070	Carbohydrate kinase
PPYC1_RS11380	COG1349	DNA-binding transcription factor activity
PPYC1_RS11385	COG0247	lactate metabolic process
PPYC1_RS11390	COG1139	Iron-sulfur cluster binding protein
PPYC1_RS11400	COG1609	Transcriptional regulator
PPYC1_RS11405	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS11410	COG0697	spore germination
PPYC1_RS11415	COG3711	transcriptional antiterminator
PPYC1_RS11420	COG2190	(PTS) system
PPYC1_RS11420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS11420	COG1263	PTS System
PPYC1_RS11425	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS11455	COG3401	FG-GAP repeat protein
PPYC1_RS11455	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS11480	COG1136	(ABC) transporter
PPYC1_RS11485	COG1136	(ABC) transporter
PPYC1_RS11485	COG0577	efflux transmembrane transporter activity
PPYC1_RS11490	COG0517	IMP dehydrogenase activity
PPYC1_RS11495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PPYC1_RS11500	COG1494	fructose-1,6-bisphosphatase
PPYC1_RS11525	COG1132	(ABC) transporter
PPYC1_RS11530	COG1132	(ABC) transporter
PPYC1_RS11550	COG1846	Transcriptional regulator
PPYC1_RS11555	COG0456	acetyltransferase
PPYC1_RS11560	COG2076	Multidrug Resistance protein
PPYC1_RS11565	COG2076	Multidrug Resistance protein
PPYC1_RS11570	COG2508	Transcriptional regulator
PPYC1_RS11580	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS11590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPYC1_RS11595	COG1447	Phosphotransferase system cellobiose-specific component IIA
PPYC1_RS11600	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS11605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PPYC1_RS11630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS11630	COG3711	transcriptional antiterminator
PPYC1_RS11640	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PPYC1_RS11640	COG2508	Transcriptional regulator
PPYC1_RS11660	COG0366	Alpha amylase catalytic
PPYC1_RS11660	COG1874	Beta-galactosidase
PPYC1_RS11665	COG0366	Alpha amylase catalytic
PPYC1_RS11675	COG0300	oxidoreductase activity
PPYC1_RS11680	COG0702	epimerase
PPYC1_RS11690	COG2205	protein histidine kinase activity
PPYC1_RS11695	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS11705	COG3275	phosphorelay sensor kinase activity
PPYC1_RS11710	COG4753	response regulator
PPYC1_RS11710	COG2207	Transcriptional regulator
PPYC1_RS11725	COG4209	transmembrane transport
PPYC1_RS11730	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS11735	COG0366	Alpha amylase catalytic
PPYC1_RS11740	COG0366	Alpha amylase catalytic
PPYC1_RS11745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PPYC1_RS11750	COG2205	protein histidine kinase activity
PPYC1_RS11760	COG0154	amidase activity
PPYC1_RS11765	COG3848	Pyruvate phosphate dikinase
PPYC1_RS11765	COG0574	Belongs to the PEP-utilizing enzyme family
PPYC1_RS11780	COG4978	Transcriptional regulator
PPYC1_RS11780	COG0789	Transcriptional regulator
PPYC1_RS11795	COG1312	Catalyzes the dehydration of D-mannonate
PPYC1_RS11800	COG0246	Mannitol dehydrogenase
PPYC1_RS11820	COG0667	Aldo Keto reductase
PPYC1_RS11825	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS11835	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS11840	COG1609	Transcriptional regulator
PPYC1_RS11850	COG0667	Aldo Keto reductase
PPYC1_RS11860	COG2207	Transcriptional regulator
PPYC1_RS11865	COG0667	Aldo Keto reductase
PPYC1_RS11870	COG4221	oxidoreductase activity
PPYC1_RS11890	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS11900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPYC1_RS11910	COG2814	Major facilitator Superfamily
PPYC1_RS11920	COG1309	transcriptional regulator
PPYC1_RS11925	COG0477	Major facilitator Superfamily
PPYC1_RS11935	COG0601	transmembrane transport
PPYC1_RS11940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS11945	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS11955	COG0534	Mate efflux family protein
PPYC1_RS11960	COG0753	catalase activity
PPYC1_RS11965	COG0529	Catalyzes the synthesis of activated sulfate
PPYC1_RS12005	COG2066	Belongs to the glutaminase family
PPYC1_RS12010	COG2514	catechol 2,3-dioxygenase activity
PPYC1_RS12015	COG2259	Doxx family
PPYC1_RS12030	COG5434	Belongs to the glycosyl hydrolase 28 family
PPYC1_RS12030	COG4632	Exopolysaccharide biosynthesis protein
PPYC1_RS12045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PPYC1_RS12050	COG2186	Transcriptional regulator
PPYC1_RS12055	COG2017	converts alpha-aldose to the beta-anomer
PPYC1_RS12060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPYC1_RS12070	COG2309	aminopeptidase activity
PPYC1_RS12080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPYC1_RS12085	COG1253	flavin adenine dinucleotide binding
PPYC1_RS12095	COG3773	Cell wall hydrolase
PPYC1_RS12100	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS12120	COG0531	amino acid
PPYC1_RS12125	COG0039	L-malate dehydrogenase activity
PPYC1_RS12145	COG3850	Histidine kinase
PPYC1_RS12145	COG5002	protein histidine kinase activity
PPYC1_RS12150	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS12165	COG2223	nitrite transmembrane transporter activity
PPYC1_RS12180	COG1193	negative regulation of DNA recombination
PPYC1_RS12185	COG1940	carbohydrate kinase activity
PPYC1_RS12190	COG0561	phosphatase activity
PPYC1_RS12200	COG4974	Belongs to the 'phage' integrase family
PPYC1_RS12215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS12220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS12225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS12230	COG1132	(ABC) transporter
PPYC1_RS12235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS12240	COG1879	ABC-type sugar transport system periplasmic component
PPYC1_RS12245	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPYC1_RS12250	COG1129	ABC transporter
PPYC1_RS12255	COG1869	D-ribose catabolic process
PPYC1_RS12260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPYC1_RS12265	COG1609	Transcriptional regulator
PPYC1_RS12270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PPYC1_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS12300	COG1473	amidohydrolase
PPYC1_RS12310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS12320	COG0747	negative chemotaxis
PPYC1_RS12330	COG4974	Belongs to the 'phage' integrase family
PPYC1_RS12335	COG1763	Mo-molybdopterin cofactor biosynthetic process
PPYC1_RS12340	COG0303	'Molybdopterin
PPYC1_RS12375	COG1842	Phage shock protein A
PPYC1_RS12380	COG1902	pentaerythritol trinitrate reductase activity
PPYC1_RS12390	COG1388	LysM domain
PPYC1_RS12390	COG3584	3D domain protein
PPYC1_RS12395	COG1126	abc transporter atp-binding protein
PPYC1_RS12400	COG0765	amino acid transport
PPYC1_RS12405	COG1473	amidohydrolase
PPYC1_RS12415	COG0297	glycogen (starch) synthase activity
PPYC1_RS12420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PPYC1_RS12425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PPYC1_RS12430	COG5002	protein histidine kinase activity
PPYC1_RS12435	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS12450	COG0477	Major facilitator Superfamily
PPYC1_RS12470	COG0493	'glutamate synthase
PPYC1_RS12475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PPYC1_RS12480	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PPYC1_RS12490	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPYC1_RS12495	COG0022	dehydrogenase e1 component
PPYC1_RS12510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPYC1_RS12515	COG1564	THIamine pyrophosphokinase
PPYC1_RS12520	COG0791	NLP P60 protein
PPYC1_RS12525	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS12530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPYC1_RS12535	COG2022	thiamine diphosphate biosynthetic process
PPYC1_RS12545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PPYC1_RS12550	COG0352	thiamine-phosphate diphosphorylase activity
PPYC1_RS12555	COG0488	(ABC) transporter
PPYC1_RS12615	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PPYC1_RS12620	COG1119	ATPase activity
PPYC1_RS12625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPYC1_RS12635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PPYC1_RS12640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PPYC1_RS12650	COG1234	tRNA 3'-trailer cleavage
PPYC1_RS12655	COG0646	methionine synthase
PPYC1_RS12655	COG1410	methionine synthase
PPYC1_RS12660	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PPYC1_RS12665	COG1011	Hydrolase
PPYC1_RS12675	COG4224	UPF0291 protein
PPYC1_RS12685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PPYC1_RS12740	COG0583	DNA-binding transcription factor activity
PPYC1_RS12745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPYC1_RS12750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PPYC1_RS12785	COG1733	regulation of RNA biosynthetic process
PPYC1_RS12810	COG0488	(ABC) transporter
PPYC1_RS12830	COG1361	Conserved repeat domain
PPYC1_RS12860	COG5484	DNA packaging
PPYC1_RS12860	COG3728	DNA packaging
PPYC1_RS12875	COG2267	carboxylic ester hydrolase activity
PPYC1_RS12925	COG0592	DNA-directed DNA polymerase activity
PPYC1_RS12930	COG0174	glutamine synthetase
PPYC1_RS12935	COG0789	Transcriptional regulator
PPYC1_RS12940	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PPYC1_RS12945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PPYC1_RS12950	COG0464	growth
PPYC1_RS12965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPYC1_RS12970	COG1923	regulation of RNA biosynthetic process
PPYC1_RS12975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PPYC1_RS12980	COG2136	Putative SAM-dependent methyltransferase
PPYC1_RS12980	COG2521	methyltransferase
PPYC1_RS12985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PPYC1_RS12990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PPYC1_RS13005	COG0583	DNA-binding transcription factor activity
PPYC1_RS13010	COG0531	amino acid
PPYC1_RS13015	COG4129	membrane
PPYC1_RS13020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PPYC1_RS13025	COG1116	anion transmembrane transporter activity
PPYC1_RS13030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PPYC1_RS13035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PPYC1_RS13040	COG0288	reversible hydration of carbon dioxide
PPYC1_RS13065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPYC1_RS13070	COG3119	arylsulfatase activity
PPYC1_RS13085	COG1566	PFAM secretion protein HlyD family protein
PPYC1_RS13090	COG2814	Major facilitator Superfamily
PPYC1_RS13095	COG1566	PFAM secretion protein HlyD family protein
PPYC1_RS13105	COG0716	FMN binding
PPYC1_RS13115	COG0564	pseudouridine synthase activity
PPYC1_RS13120	COG2814	Major facilitator Superfamily
PPYC1_RS13125	COG1846	Transcriptional regulator
PPYC1_RS13135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PPYC1_RS13150	COG1131	(ABC) transporter
PPYC1_RS13165	COG2340	Cysteine-rich secretory protein family
PPYC1_RS13175	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PPYC1_RS13180	COG1132	(ABC) transporter
PPYC1_RS13185	COG1132	(ABC) transporter
PPYC1_RS13190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PPYC1_RS13205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PPYC1_RS13215	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPYC1_RS13220	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPYC1_RS13225	COG0066	3-isopropylmalate dehydratase activity
PPYC1_RS13230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PPYC1_RS13235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PPYC1_RS13305	COG2030	dehydratase
PPYC1_RS13315	COG3383	formate dehydrogenase (NAD+) activity
PPYC1_RS13320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPYC1_RS13330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PPYC1_RS13330	COG0493	'glutamate synthase
PPYC1_RS13335	COG1027	Aspartate ammonia-lyase
PPYC1_RS13350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PPYC1_RS13355	COG1785	Belongs to the alkaline phosphatase family
PPYC1_RS13360	COG1228	amidohydrolase
PPYC1_RS13365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PPYC1_RS13370	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS13375	COG4172	Belongs to the ABC transporter superfamily
PPYC1_RS13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS13390	COG4166	transmembrane transport
PPYC1_RS13395	COG0583	DNA-binding transcription factor activity
PPYC1_RS13415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PPYC1_RS13420	COG0436	Aminotransferase
PPYC1_RS13425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PPYC1_RS13430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PPYC1_RS13440	COG1850	ribulose-bisphosphate carboxylase activity
PPYC1_RS13445	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PPYC1_RS13450	COG0235	Class ii aldolase
PPYC1_RS13455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PPYC1_RS13480	COG3935	DnaD domain protein
PPYC1_RS13485	COG0017	Asparaginyl-tRNA synthetase
PPYC1_RS13490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PPYC1_RS13495	COG1250	3-hydroxyacyl-CoA dehydrogenase
PPYC1_RS13500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPYC1_RS13515	COG0402	S-adenosylhomocysteine deaminase activity
PPYC1_RS13520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PPYC1_RS13525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PPYC1_RS13525	COG1199	ATP-dependent helicase activity
PPYC1_RS13535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PPYC1_RS13540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PPYC1_RS13545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PPYC1_RS13555	COG0617	tRNA 3'-terminal CCA addition
PPYC1_RS13560	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS13565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PPYC1_RS13570	COG1803	Methylglyoxal synthase
PPYC1_RS13575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PPYC1_RS13585	COG1694	Mazg nucleotide pyrophosphohydrolase
PPYC1_RS13590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS13605	COG4347	Protein of unknown function (DUF1405)
PPYC1_RS13625	COG0588	phosphoglycerate mutase activity
PPYC1_RS13640	COG0287	Prephenate dehydrogenase
PPYC1_RS13645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PPYC1_RS13650	COG0159	tryptophan synthase activity
PPYC1_RS13655	COG0133	tryptophan synthase activity
PPYC1_RS13660	COG0135	phosphoribosylanthranilate isomerase activity
PPYC1_RS13665	COG0134	indole-3-glycerol-phosphate synthase activity
PPYC1_RS13670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPYC1_RS13680	COG4401	Chorismate mutase type I
PPYC1_RS13685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PPYC1_RS13690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PPYC1_RS13695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPYC1_RS13700	COG0105	UTP biosynthetic process
PPYC1_RS13710	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPYC1_RS13715	COG0163	prenyltransferase activity
PPYC1_RS13720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PPYC1_RS13725	COG2226	methyltransferase
PPYC1_RS13750	COG0776	regulation of translation
PPYC1_RS13755	COG1172	Belongs to the binding-protein-dependent transport system permease family
PPYC1_RS13760	COG1129	ABC transporter
PPYC1_RS13780	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PPYC1_RS13785	COG2871	sodium ion transport
PPYC1_RS13800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PPYC1_RS13805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PPYC1_RS13810	COG1160	GTP binding
PPYC1_RS13830	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PPYC1_RS13835	COG2959	enzyme of heme biosynthesis
PPYC1_RS13840	COG2339	peptidase activity
PPYC1_RS13845	COG4862	establishment of competence for transformation
PPYC1_RS13855	COG0726	polysaccharide deacetylase
PPYC1_RS13870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PPYC1_RS13875	COG5002	protein histidine kinase activity
PPYC1_RS13880	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS13885	COG1187	pseudouridine synthase activity
PPYC1_RS13890	COG0700	Nucleoside recognition
PPYC1_RS13895	COG2715	membrane protein required for spore maturation
PPYC1_RS13900	COG1686	Belongs to the peptidase S11 family
PPYC1_RS13910	COG3874	Sporulation protein YtfJ
PPYC1_RS13920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PPYC1_RS13925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PPYC1_RS13935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPYC1_RS13935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PPYC1_RS13950	COG0674	pyruvate-flavodoxin oxidoreductase activity
PPYC1_RS13960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PPYC1_RS13965	COG0019	diaminopimelate decarboxylase activity
PPYC1_RS13970	COG0697	spore germination
PPYC1_RS13990	COG2172	sigma factor antagonist activity
PPYC1_RS13995	COG1366	Belongs to the anti-sigma-factor antagonist family
PPYC1_RS14000	COG1686	Belongs to the peptidase S11 family
PPYC1_RS14020	COG4974	Belongs to the 'phage' integrase family
PPYC1_RS14030	COG0735	belongs to the Fur family
PPYC1_RS14035	COG1300	Membrane
PPYC1_RS14040	COG1379	DNA repair
PPYC1_RS14045	COG0494	nUDIX hydrolase
PPYC1_RS14055	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPYC1_RS14060	COG0321	lipoyl(octanoyl) transferase activity
PPYC1_RS14065	COG0508	dehydrogenase complex catalyzes the overall conversion of
PPYC1_RS14070	COG0022	dehydrogenase e1 component
PPYC1_RS14075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PPYC1_RS14080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PPYC1_RS14090	COG1435	thymidine kinase activity
PPYC1_RS14095	COG4326	sporulation control protein
PPYC1_RS14110	COG0840	transmembrane signaling receptor activity
PPYC1_RS14120	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS14125	COG0750	zinc metalloprotease
PPYC1_RS14130	COG0497	DNA recombination
PPYC1_RS14135	COG1438	arginine binding
PPYC1_RS14145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PPYC1_RS14150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PPYC1_RS14155	COG0142	geranyltranstransferase activity
PPYC1_RS14160	COG1722	exodeoxyribonuclease VII activity
PPYC1_RS14170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PPYC1_RS14175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPYC1_RS14190	COG1302	Protein conserved in bacteria
PPYC1_RS14195	COG0439	Biotin carboxylase
PPYC1_RS14200	COG0511	ligase activity, forming carbon-carbon bonds
PPYC1_RS14240	COG3854	ATPases associated with a variety of cellular activities
PPYC1_RS14250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PPYC1_RS14255	COG0006	proline dipeptidase activity
PPYC1_RS14270	COG3872	metal-dependent enzyme
PPYC1_RS14280	COG1752	Esterase of the alpha-beta hydrolase superfamily
PPYC1_RS14285	COG1649	PFAM Uncharacterised BCR, COG1649
PPYC1_RS14290	COG1321	iron dependent repressor
PPYC1_RS14295	COG1533	DNA photolyase activity
PPYC1_RS14300	COG0785	Cytochrome C biogenesis protein
PPYC1_RS14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPYC1_RS14305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PPYC1_RS14310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PPYC1_RS14315	COG0735	belongs to the Fur family
PPYC1_RS14325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PPYC1_RS14335	COG1454	alcohol dehydrogenase
PPYC1_RS14335	COG1012	belongs to the aldehyde dehydrogenase family
PPYC1_RS14345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPYC1_RS14350	COG3384	dioxygenase
PPYC1_RS14360	COG1733	regulation of RNA biosynthetic process
PPYC1_RS14375	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS14385	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS14400	COG3534	alpha-L-arabinofuranosidase
PPYC1_RS14415	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS14420	COG0861	Integral membrane protein TerC family
PPYC1_RS14425	COG0398	Pfam SNARE associated Golgi protein
PPYC1_RS14430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPYC1_RS14430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PPYC1_RS14440	COG4876	unkown
PPYC1_RS14445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS14460	COG0697	spore germination
PPYC1_RS14465	COG0531	amino acid
PPYC1_RS14475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PPYC1_RS14480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PPYC1_RS14490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PPYC1_RS14495	COG1307	EDD domain protein, DegV family
PPYC1_RS14500	COG1461	Dihydroxyacetone kinase
PPYC1_RS14505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PPYC1_RS14520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PPYC1_RS14525	COG1162	GTPase activity
PPYC1_RS14530	COG2815	serine threonine protein kinase
PPYC1_RS14530	COG0515	serine threonine protein kinase
PPYC1_RS14535	COG0631	protein serine/threonine phosphatase activity
PPYC1_RS14540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPYC1_RS14545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PPYC1_RS14545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PPYC1_RS14555	COG0242	peptide deformylase activity
PPYC1_RS14560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PPYC1_RS14565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PPYC1_RS14570	COG1758	RNA polymerase activity
PPYC1_RS14575	COG0194	GDP metabolic process
PPYC1_RS14580	COG2052	Domain of unknown function (DUF370)
PPYC1_RS14585	COG1561	YicC-like family, N-terminal region
PPYC1_RS14590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PPYC1_RS14590	COG0646	methionine synthase
PPYC1_RS14600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PPYC1_RS14605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PPYC1_RS14615	COG0613	PHP domain protein
PPYC1_RS14630	COG4471	UPF0298 protein
PPYC1_RS14650	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PPYC1_RS14655	COG1473	amidohydrolase
PPYC1_RS14660	COG0772	Belongs to the SEDS family
PPYC1_RS14665	COG1302	Protein conserved in bacteria
PPYC1_RS14670	COG0387	Pfam Sodium calcium exchanger
PPYC1_RS14675	COG4838	Belongs to the UPF0358 family
PPYC1_RS14685	COG2309	aminopeptidase activity
PPYC1_RS14695	COG2199	diguanylate cyclase activity
PPYC1_RS14695	COG2203	Gaf domain
PPYC1_RS14700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PPYC1_RS14705	COG3708	Transcriptional regulator
PPYC1_RS14705	COG2207	Transcriptional regulator
PPYC1_RS14710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PPYC1_RS14720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PPYC1_RS14725	COG0454	-acetyltransferase
PPYC1_RS14730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPYC1_RS14735	COG1609	Transcriptional regulator
PPYC1_RS14750	COG0693	protein deglycase activity
PPYC1_RS14755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PPYC1_RS14760	COG2190	(PTS) system
PPYC1_RS14760	COG1263	PTS System
PPYC1_RS14760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS14765	COG1832	CoA-binding protein
PPYC1_RS14770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PPYC1_RS14775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PPYC1_RS14780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PPYC1_RS14795	COG4493	Belongs to the UPF0637 family
PPYC1_RS14805	COG1982	Orn Lys Arg decarboxylase major
PPYC1_RS14820	COG1234	tRNA 3'-trailer cleavage
PPYC1_RS14830	COG2153	protein acetylation
PPYC1_RS14840	COG2146	nitrite reductase [NAD(P)H] activity
PPYC1_RS14845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS14850	COG3707	response regulator
PPYC1_RS14855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PPYC1_RS14860	COG0243	molybdopterin cofactor binding
PPYC1_RS14865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS14870	COG2223	nitrite transmembrane transporter activity
PPYC1_RS14875	COG0281	malic enzyme
PPYC1_RS14880	COG0679	Auxin Efflux Carrier
PPYC1_RS14895	COG1874	Beta-galactosidase
PPYC1_RS14900	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS14905	COG4209	transmembrane transport
PPYC1_RS14915	COG2207	Transcriptional regulator
PPYC1_RS14915	COG4753	response regulator
PPYC1_RS14920	COG3275	phosphorelay sensor kinase activity
PPYC1_RS14925	COG3209	COG3209 Rhs family protein
PPYC1_RS14970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPYC1_RS14975	COG2070	2-Nitropropane dioxygenase
PPYC1_RS14975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPYC1_RS14980	COG3321	synthase
PPYC1_RS14985	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS14990	COG4221	oxidoreductase activity
PPYC1_RS14990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS14990	COG3321	synthase
PPYC1_RS14995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPYC1_RS14995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS14995	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS14995	COG3321	synthase
PPYC1_RS14995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS15000	COG3321	synthase
PPYC1_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS15000	COG4221	oxidoreductase activity
PPYC1_RS15000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS15005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS15005	COG0318	PFAM AMP-dependent synthetase and ligase
PPYC1_RS15005	COG0300	oxidoreductase activity
PPYC1_RS15005	COG3321	synthase
PPYC1_RS15010	COG1024	Enoyl-CoA hydratase
PPYC1_RS15015	COG1024	Enoyl-CoA hydratase
PPYC1_RS15020	COG3425	synthase
PPYC1_RS15025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PPYC1_RS15030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS15045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPYC1_RS15130	COG4824	toxin secretion phage lysis holin
PPYC1_RS15170	COG1742	UPF0060 membrane protein
PPYC1_RS15195	COG0371	Dehydrogenase
PPYC1_RS15250	COG0583	DNA-binding transcription factor activity
PPYC1_RS15265	COG1073	alpha beta
PPYC1_RS15275	COG1653	transport
PPYC1_RS15285	COG4209	transmembrane transport
PPYC1_RS15290	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS15295	COG2207	Transcriptional regulator
PPYC1_RS15300	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS15310	COG1280	lysine exporter protein (LysE YggA)
PPYC1_RS15335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PPYC1_RS15345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PPYC1_RS15360	COG0564	pseudouridine synthase activity
PPYC1_RS15365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PPYC1_RS15370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PPYC1_RS15385	COG3599	regulation of cell shape
PPYC1_RS15390	COG2302	S4 RNA-binding domain
PPYC1_RS15395	COG0762	integral membrane protein
PPYC1_RS15400	COG1799	cell septum assembly
PPYC1_RS15405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PPYC1_RS15410	COG1496	oxidoreductase activity
PPYC1_RS15415	COG1873	PFAM PRC-barrel domain
PPYC1_RS15420	COG1191	sigma factor activity
PPYC1_RS15425	COG1191	sigma factor activity
PPYC1_RS15435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PPYC1_RS15440	COG0849	cell division
PPYC1_RS15445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PPYC1_RS15450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPYC1_RS15455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PPYC1_RS15460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PPYC1_RS15465	COG0772	Belongs to the SEDS family
PPYC1_RS15470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PPYC1_RS15475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPYC1_RS15480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PPYC1_RS15490	COG0768	penicillin binding
PPYC1_RS15495	COG0768	penicillin binding
PPYC1_RS15505	COG0275	rRNA processing
PPYC1_RS15510	COG2001	Belongs to the MraZ family
PPYC1_RS15515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PPYC1_RS15520	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PPYC1_RS15525	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS15530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS15535	COG0601	transmembrane transport
PPYC1_RS15540	COG4166	transmembrane transport
PPYC1_RS15550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PPYC1_RS15565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PPYC1_RS15570	COG1316	TRANSCRIPTIONal
PPYC1_RS15575	COG1217	gtp-binding protein TYPA
PPYC1_RS15585	COG0861	Integral membrane protein TerC family
PPYC1_RS15590	COG0861	Integral membrane protein TerC family
PPYC1_RS15595	COG0301	tRNA thio-modification
PPYC1_RS15600	COG1104	cysteine desulfurase activity
PPYC1_RS15605	COG0741	lytic transglycosylase activity
PPYC1_RS15635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS15640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS15655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PPYC1_RS15660	COG2384	SAM-dependent methyltransferase
PPYC1_RS15675	COG0358	DNA primase activity
PPYC1_RS15680	COG1671	Belongs to the UPF0178 family
PPYC1_RS15685	COG0751	glycine-tRNA ligase activity
PPYC1_RS15690	COG0752	glycyl-tRNA synthetase alpha subunit
PPYC1_RS15695	COG1381	Involved in DNA repair and RecF pathway recombination
PPYC1_RS15705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PPYC1_RS15710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PPYC1_RS15715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PPYC1_RS15720	COG1480	7TM receptor with intracellular HD hydrolase
PPYC1_RS15725	COG1702	phosphate starvation-inducible protein PhoH
PPYC1_RS15740	COG0531	amino acid
PPYC1_RS15750	COG4864	UPF0365 protein
PPYC1_RS15755	COG1030	water channel activity
PPYC1_RS15760	COG1610	YqeY-like protein
PPYC1_RS15765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PPYC1_RS15770	COG0537	adenosine 5'-monophosphoramidase activity
PPYC1_RS15775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS15785	COG0419	ATPase involved in DNA repair
PPYC1_RS15790	COG0420	3'-5' exonuclease activity
PPYC1_RS15795	COG1074	ATP-dependent DNA helicase activity
PPYC1_RS15800	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PPYC1_RS15810	COG1283	sodium-dependent phosphate transmembrane transporter activity
PPYC1_RS15820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PPYC1_RS15825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PPYC1_RS15830	COG1994	Peptidase M50
PPYC1_RS15860	COG3493	citrate carrier protein
PPYC1_RS15865	COG4565	transcriptional regulatory protein
PPYC1_RS15870	COG3290	protein histidine kinase activity
PPYC1_RS15890	COG1420	regulation of RNA biosynthetic process
PPYC1_RS15905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PPYC1_RS15910	COG0481	GTPase activity
PPYC1_RS15920	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPYC1_RS15925	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PPYC1_RS15930	COG0268	Binds directly to 16S ribosomal RNA
PPYC1_RS15935	COG1466	dna polymerase III delta subunit
PPYC1_RS15945	COG1595	DNA-templated transcription, initiation
PPYC1_RS15950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PPYC1_RS15955	COG2333	competence protein COMEC
PPYC1_RS15955	COG0658	competence protein
PPYC1_RS15965	COG1555	photosystem II stabilization
PPYC1_RS15970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PPYC1_RS15975	COG0495	leucyl-tRNA aminoacylation
PPYC1_RS15980	COG1942	4-Oxalocrotonate Tautomerase
PPYC1_RS15985	COG2226	methyltransferase
PPYC1_RS15990	COG2996	Protein conserved in bacteria
PPYC1_RS15995	COG0799	negative regulation of ribosome biogenesis
PPYC1_RS16000	COG1713	HD superfamily hydrolase involved in NAD metabolism
PPYC1_RS16005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PPYC1_RS16010	COG1534	Rna-binding protein
PPYC1_RS16015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PPYC1_RS16020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PPYC1_RS16025	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PPYC1_RS16030	COG1305	Transglutaminase-like
PPYC1_RS16040	COG0714	Associated with various cellular activities
PPYC1_RS16050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PPYC1_RS16060	COG1363	Peptidase, m42
PPYC1_RS16070	COG4305	rare lipoprotein A
PPYC1_RS16080	COG1653	transport
PPYC1_RS16085	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS16090	COG4209	transmembrane transport
PPYC1_RS16110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PPYC1_RS16115	COG0697	spore germination
PPYC1_RS16125	COG1683	Conserved Protein
PPYC1_RS16190	COG5609	conserved protein (DUF2294)
PPYC1_RS16205	COG3420	alginic acid biosynthetic process
PPYC1_RS16210	COG4149	molybdate abc transporter
PPYC1_RS16215	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPYC1_RS16220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPYC1_RS16225	COG0314	molybdopterin synthase activity
PPYC1_RS16235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PPYC1_RS16245	COG3383	formate dehydrogenase (NAD+) activity
PPYC1_RS16250	COG2427	Protein of unknown function (DUF1641)
PPYC1_RS16270	COG4977	sequence-specific DNA binding
PPYC1_RS16280	COG1744	ABC transporter substrate-binding protein PnrA-like
PPYC1_RS16295	COG1027	Aspartate ammonia-lyase
PPYC1_RS16310	COG1361	Conserved repeat domain
PPYC1_RS16315	COG0436	Aminotransferase
PPYC1_RS16330	COG1177	transmembrane transport
PPYC1_RS16335	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPYC1_RS16345	COG1473	amidohydrolase
PPYC1_RS16350	COG2171	N-acyltransferase activity
PPYC1_RS16360	COG0697	spore germination
PPYC1_RS16365	COG2897	thiosulfate sulfurtransferase activity
PPYC1_RS16380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS16385	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
PPYC1_RS16390	COG1660	Displays ATPase and GTPase activities
PPYC1_RS16480	COG1051	belongs to the nudix hydrolase family
PPYC1_RS16525	COG2318	DinB family
PPYC1_RS16590	COG0789	Transcriptional regulator
PPYC1_RS16625	COG4974	Belongs to the 'phage' integrase family
PPYC1_RS16630	COG0840	transmembrane signaling receptor activity
PPYC1_RS16650	COG1397	ADP-ribosylglycohydrolase
PPYC1_RS16675	COG5278	phosphoserine phosphatase activity
PPYC1_RS16675	COG0840	transmembrane signaling receptor activity
PPYC1_RS16680	COG0383	alpha-mannosidase activity
PPYC1_RS16700	COG1472	Belongs to the glycosyl hydrolase 3 family
PPYC1_RS16705	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS16710	COG4209	transmembrane transport
PPYC1_RS16715	COG1653	transport
PPYC1_RS16725	COG3275	phosphorelay sensor kinase activity
PPYC1_RS16765	COG2814	Major facilitator Superfamily
PPYC1_RS16770	COG3250	beta-galactosidase activity
PPYC1_RS16775	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS16780	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS16790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PPYC1_RS16795	COG0747	negative chemotaxis
PPYC1_RS16800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS16805	COG0601	transmembrane transport
PPYC1_RS16820	COG2814	Major facilitator Superfamily
PPYC1_RS16825	COG1361	Conserved repeat domain
PPYC1_RS16840	COG0596	Alpha beta hydrolase
PPYC1_RS16845	COG0840	transmembrane signaling receptor activity
PPYC1_RS16850	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS16855	COG2190	(PTS) system
PPYC1_RS16855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS16855	COG1263	PTS System
PPYC1_RS16860	COG3711	transcriptional antiterminator
PPYC1_RS16865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PPYC1_RS16880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PPYC1_RS16885	COG2223	nitrite transmembrane transporter activity
PPYC1_RS16895	COG2197	response regulator
PPYC1_RS16900	COG4585	Histidine kinase
PPYC1_RS16910	COG2181	nitrate reductase activity
PPYC1_RS16920	COG1140	nitrate reductase beta subunit
PPYC1_RS16925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PPYC1_RS16930	COG4149	molybdate abc transporter
PPYC1_RS16935	COG0725	ABC transporter, periplasmic molybdate-binding protein
PPYC1_RS16945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PPYC1_RS16950	COG0535	radical SAM domain protein
PPYC1_RS17015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPYC1_RS17020	COG0436	Aminotransferase
PPYC1_RS17025	COG1464	Belongs to the NlpA lipoprotein family
PPYC1_RS17030	COG1388	LysM domain
PPYC1_RS17045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPYC1_RS17050	COG2169	Transcriptional regulator
PPYC1_RS17055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PPYC1_RS17080	COG2814	Major facilitator Superfamily
PPYC1_RS17090	COG4221	oxidoreductase activity
PPYC1_RS17100	COG2207	Transcriptional regulator
PPYC1_RS17115	COG1063	alcohol dehydrogenase
PPYC1_RS17125	COG2304	oxidoreductase activity
PPYC1_RS17130	COG1113	amino acid transport
PPYC1_RS17140	COG0778	Nitroreductase
PPYC1_RS17145	COG1846	Transcriptional regulator
PPYC1_RS17150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PPYC1_RS17160	COG0312	modulator of DNA gyrase
PPYC1_RS17165	COG0312	modulator of DNA gyrase
PPYC1_RS17240	COG0076	glutamate decarboxylase activity
PPYC1_RS17260	COG0693	protein deglycase activity
PPYC1_RS17285	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS17305	COG2972	Histidine kinase
PPYC1_RS17310	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS17320	COG1917	Cupin 2, conserved barrel domain protein
PPYC1_RS17330	COG1609	Transcriptional regulator
PPYC1_RS17335	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PPYC1_RS17345	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS17380	COG3866	Pectate lyase
PPYC1_RS17385	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS17390	COG5002	protein histidine kinase activity
PPYC1_RS17395	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS17410	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PPYC1_RS17445	COG4412	M6 family metalloprotease domain protein
PPYC1_RS17445	COG1404	Belongs to the peptidase S8 family
PPYC1_RS17450	COG4412	M6 family metalloprotease domain protein
PPYC1_RS17450	COG1404	Belongs to the peptidase S8 family
PPYC1_RS17455	COG0659	secondary active sulfate transmembrane transporter activity
PPYC1_RS17470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PPYC1_RS17475	COG2814	Major facilitator Superfamily
PPYC1_RS17480	COG1126	abc transporter atp-binding protein
PPYC1_RS17485	COG0765	amino acid transport
PPYC1_RS17490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS17500	COG2261	transglycosylase associated protein
PPYC1_RS17510	COG3458	cephalosporin-C deacetylase activity
PPYC1_RS17520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS17535	COG2376	Dihydroxyacetone kinase
PPYC1_RS17545	COG2169	Transcriptional regulator
PPYC1_RS17600	COG1714	RDD family
PPYC1_RS17640	COG0484	heat shock protein binding
PPYC1_RS17660	COG0515	serine threonine protein kinase
PPYC1_RS17660	COG2815	serine threonine protein kinase
PPYC1_RS17665	COG2223	nitrite transmembrane transporter activity
PPYC1_RS17670	COG3279	Response regulator of the LytR AlgR family
PPYC1_RS17675	COG3275	phosphorelay sensor kinase activity
PPYC1_RS17680	COG1619	proteins homologs of microcin C7 resistance protein MccF
PPYC1_RS17685	COG0840	transmembrane signaling receptor activity
PPYC1_RS17690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PPYC1_RS17695	COG1523	belongs to the glycosyl hydrolase 13 family
PPYC1_RS17700	COG1132	(ABC) transporter
PPYC1_RS17705	COG4988	ABC transporter
PPYC1_RS17710	COG0246	Mannitol dehydrogenase
PPYC1_RS17715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS17720	COG3711	transcriptional antiterminator
PPYC1_RS17735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PPYC1_RS17740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPYC1_RS17745	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PPYC1_RS17760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS17760	COG2190	(PTS) system
PPYC1_RS17760	COG1263	PTS System
PPYC1_RS17765	COG3711	transcriptional antiterminator
PPYC1_RS17770	COG2268	Band 7 protein
PPYC1_RS17780	COG1979	alcohol dehydrogenase
PPYC1_RS17785	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PPYC1_RS17790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PPYC1_RS17795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PPYC1_RS17805	COG0667	Aldo Keto reductase
PPYC1_RS17810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PPYC1_RS17815	COG0546	phosphoglycolate phosphatase activity
PPYC1_RS17825	COG3594	Acyltransferase
PPYC1_RS17835	COG0129	dihydroxy-acid dehydratase activity
PPYC1_RS17845	COG0628	permease
PPYC1_RS17850	COG0768	penicillin binding
PPYC1_RS17855	COG0840	transmembrane signaling receptor activity
PPYC1_RS17860	COG0826	peptidase U32
PPYC1_RS17865	COG0826	peptidase U32
PPYC1_RS17870	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PPYC1_RS17880	COG3906	Belongs to the UPF0473 family
PPYC1_RS17890	COG4472	Bacterial protein of unknown function (DUF965)
PPYC1_RS17895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPYC1_RS17900	COG0628	permease
PPYC1_RS17920	COG1104	cysteine desulfurase activity
PPYC1_RS17925	COG1959	2 iron, 2 sulfur cluster binding
PPYC1_RS17930	COG0482	sulfurtransferase activity
PPYC1_RS17935	COG2326	polyphosphate kinase activity
PPYC1_RS17940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPYC1_RS17945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PPYC1_RS17950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPYC1_RS18035	COG0300	oxidoreductase activity
PPYC1_RS18035	COG4221	oxidoreductase activity
PPYC1_RS18035	COG3321	synthase
PPYC1_RS18035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS18035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS18035	COG3321	synthase
PPYC1_RS18035	COG0300	oxidoreductase activity
PPYC1_RS18035	COG4221	oxidoreductase activity
PPYC1_RS18040	COG0300	oxidoreductase activity
PPYC1_RS18040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS18040	COG4221	oxidoreductase activity
PPYC1_RS18040	COG3321	synthase
PPYC1_RS18045	COG3321	synthase
PPYC1_RS18045	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS18045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS18045	COG4221	oxidoreductase activity
PPYC1_RS18050	COG4221	oxidoreductase activity
PPYC1_RS18050	COG3321	synthase
PPYC1_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS18050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS18055	COG0318	PFAM AMP-dependent synthetase and ligase
PPYC1_RS18055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PPYC1_RS18055	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS18055	COG0300	oxidoreductase activity
PPYC1_RS18055	COG3321	synthase
PPYC1_RS18060	COG2070	2-Nitropropane dioxygenase
PPYC1_RS18060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PPYC1_RS18065	COG3321	synthase
PPYC1_RS18070	COG4585	Histidine kinase
PPYC1_RS18075	COG2197	response regulator
PPYC1_RS18105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPYC1_RS18110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PPYC1_RS18115	COG3973	AAA domain
PPYC1_RS18120	COG1132	(ABC) transporter
PPYC1_RS18130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PPYC1_RS18135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PPYC1_RS18140	COG0124	histidyl-tRNA synthetase
PPYC1_RS18150	COG0693	protein deglycase activity
PPYC1_RS18155	COG1490	D-aminoacyl-tRNA deacylase activity
PPYC1_RS18160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PPYC1_RS18170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPYC1_RS18175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PPYC1_RS18175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PPYC1_RS18185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPYC1_RS18190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPYC1_RS18190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PPYC1_RS18200	COG2244	polysaccharide biosynthetic process
PPYC1_RS18205	COG2323	membrane
PPYC1_RS18215	COG1862	Preprotein translocase
PPYC1_RS18225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PPYC1_RS18230	COG2385	sporulation resulting in formation of a cellular spore
PPYC1_RS18230	COG2385	sporulation resulting in formation of a cellular spore
PPYC1_RS18235	COG2255	four-way junction helicase activity
PPYC1_RS18240	COG0632	four-way junction helicase activity
PPYC1_RS18245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PPYC1_RS18325	COG1388	LysM domain
PPYC1_RS18325	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPYC1_RS18330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PPYC1_RS18335	COG0077	Prephenate dehydratase
PPYC1_RS18340	COG0083	homoserine kinase activity
PPYC1_RS18345	COG0460	homoserine dehydrogenase
PPYC1_RS18350	COG4492	Belongs to the UPF0735 family
PPYC1_RS18355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PPYC1_RS18370	COG2868	ribosomal protein
PPYC1_RS18375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PPYC1_RS18385	COG1994	Peptidase M50
PPYC1_RS18395	COG2894	cell division
PPYC1_RS18400	COG0850	regulation of cytokinetic process
PPYC1_RS18415	COG1077	Cell shape determining protein MreB Mrl
PPYC1_RS18420	COG2003	Belongs to the UPF0758 family
PPYC1_RS18425	COG0424	maF-like protein
PPYC1_RS18440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PPYC1_RS18445	COG0285	dihydrofolate synthase activity
PPYC1_RS18450	COG0525	valine-tRNA ligase activity
PPYC1_RS18455	COG1388	LysM domain
PPYC1_RS18460	COG0564	pseudouridine synthase activity
PPYC1_RS18465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PPYC1_RS18470	COG0113	porphobilinogen synthase activity
PPYC1_RS18485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PPYC1_RS18485	COG1648	precorrin-2 dehydrogenase activity
PPYC1_RS18500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PPYC1_RS18510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PPYC1_RS18520	COG1067	ATP-dependent peptidase activity
PPYC1_RS18520	COG0470	DNA polymerase III
PPYC1_RS18530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PPYC1_RS18535	COG0740	serine-type endopeptidase activity
PPYC1_RS18540	COG0544	peptidyl-prolyl cis-trans isomerase activity
PPYC1_RS18560	COG0708	Exodeoxyribonuclease III
PPYC1_RS18570	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS18575	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS18580	COG1175	transmembrane transport
PPYC1_RS18595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PPYC1_RS18600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PPYC1_RS18605	COG1263	PTS System
PPYC1_RS18605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS18620	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS18625	COG1979	alcohol dehydrogenase
PPYC1_RS18630	COG1115	amino acid carrier protein
PPYC1_RS18635	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS18640	COG1609	Transcriptional regulator
PPYC1_RS18645	COG3711	transcriptional antiterminator
PPYC1_RS18650	COG1263	PTS System
PPYC1_RS18650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS18650	COG2190	(PTS) system
PPYC1_RS18660	COG0662	Cupin 2, conserved barrel domain protein
PPYC1_RS18660	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PPYC1_RS18690	COG1216	Glycosyl transferase, family 2
PPYC1_RS18690	COG1442	glycosyl transferase family 8
PPYC1_RS18710	COG0281	malic enzyme
PPYC1_RS18715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PPYC1_RS18720	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PPYC1_RS18725	COG0351	phosphomethylpyrimidine kinase
PPYC1_RS18730	COG0352	thiamine-phosphate diphosphorylase activity
PPYC1_RS18745	COG1609	Transcriptional regulator
PPYC1_RS18750	COG1486	melibiose metabolic process
PPYC1_RS18770	COG0367	asparagine synthase
PPYC1_RS18775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PPYC1_RS18780	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PPYC1_RS18785	COG5401	PFAM Sporulation and spore germination
PPYC1_RS18790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PPYC1_RS18800	COG0300	oxidoreductase activity
PPYC1_RS18810	COG0702	epimerase
PPYC1_RS18820	COG2226	methyltransferase
PPYC1_RS18825	COG1801	Protein of unknown function DUF72
PPYC1_RS18830	COG0457	Tetratricopeptide repeat
PPYC1_RS18830	COG0463	Glycosyl transferase, family 2
PPYC1_RS18845	COG1086	Polysaccharide biosynthesis protein
PPYC1_RS18860	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS18860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PPYC1_RS18870	COG0840	transmembrane signaling receptor activity
PPYC1_RS18880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PPYC1_RS18885	COG0500	methyltransferase
PPYC1_RS18925	COG2197	response regulator
PPYC1_RS18930	COG2822	iron ion transport
PPYC1_RS18935	COG2837	iron assimilation
PPYC1_RS18940	COG0672	)-iron permease
PPYC1_RS18975	COG1131	(ABC) transporter
PPYC1_RS18985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PPYC1_RS19005	COG1737	Transcriptional regulator
PPYC1_RS19010	COG0363	glucosamine-6-phosphate deaminase activity
PPYC1_RS19015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PPYC1_RS19095	COG1263	PTS System
PPYC1_RS19095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS19095	COG2190	(PTS) system
PPYC1_RS19100	COG3192	ethanolamine utilization protein
PPYC1_RS19115	COG1609	Transcriptional regulator
PPYC1_RS19120	COG0492	ferredoxin-NADP+ reductase activity
PPYC1_RS19125	COG1959	2 iron, 2 sulfur cluster binding
PPYC1_RS19130	COG3711	transcriptional antiterminator
PPYC1_RS19130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS19135	COG1447	Phosphotransferase system cellobiose-specific component IIA
PPYC1_RS19140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPYC1_RS19145	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS19205	COG0463	Glycosyl transferase, family 2
PPYC1_RS19220	COG1086	Polysaccharide biosynthesis protein
PPYC1_RS19265	COG1216	Glycosyl transferase, family 2
PPYC1_RS19265	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS19270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PPYC1_RS19290	COG3227	Zinc metalloprotease (Elastase)
PPYC1_RS19295	COG3227	Zinc metalloprotease (Elastase)
PPYC1_RS19315	COG0688	phosphatidylethanolamine metabolic process
PPYC1_RS19340	COG1131	(ABC) transporter
PPYC1_RS19350	COG0300	oxidoreductase activity
PPYC1_RS19360	COG0583	DNA-binding transcription factor activity
PPYC1_RS19365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PPYC1_RS19370	COG2357	RelA SpoT domain protein
PPYC1_RS19385	COG0477	Major facilitator Superfamily
PPYC1_RS19405	COG1408	metallophosphoesterase
PPYC1_RS19410	COG2746	aminoglycoside 3-N-acetyltransferase activity
PPYC1_RS19415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PPYC1_RS19420	COG1053	succinate dehydrogenase
PPYC1_RS19425	COG2009	succinate dehydrogenase
PPYC1_RS19430	COG0583	DNA-binding transcription factor activity
PPYC1_RS19435	COG0569	domain protein
PPYC1_RS19440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PPYC1_RS19455	COG0322	excinuclease ABC activity
PPYC1_RS19460	COG3118	belongs to the thioredoxin family
PPYC1_RS19465	COG1484	DNA-dependent DNA replication
PPYC1_RS19480	COG1252	NADH dehydrogenase
PPYC1_RS19485	COG0492	ferredoxin-NADP+ reductase activity
PPYC1_RS19495	COG0189	ligase activity
PPYC1_RS19505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PPYC1_RS19515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PPYC1_RS19520	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PPYC1_RS19550	COG0697	spore germination
PPYC1_RS19555	COG0583	DNA-binding transcription factor activity
PPYC1_RS19560	COG2323	membrane
PPYC1_RS19570	COG1595	DNA-templated transcription, initiation
PPYC1_RS19575	COG1132	(ABC) transporter
PPYC1_RS19580	COG2197	response regulator
PPYC1_RS19590	COG0316	Belongs to the HesB IscA family
PPYC1_RS19600	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PPYC1_RS19605	COG1252	NADH dehydrogenase
PPYC1_RS19615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPYC1_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS19625	COG1464	Belongs to the NlpA lipoprotein family
PPYC1_RS19630	COG2011	ABC-type metal ion transport system permease component
PPYC1_RS19635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PPYC1_RS19645	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PPYC1_RS19650	COG1612	heme a metabolic process
PPYC1_RS19660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPYC1_RS19680	COG0561	phosphatase activity
PPYC1_RS19685	COG0768	penicillin binding
PPYC1_RS19690	COG0768	penicillin binding
PPYC1_RS19710	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PPYC1_RS19715	COG0109	protoheme IX farnesyltransferase activity
PPYC1_RS19720	COG1988	membrane-bound metal-dependent
PPYC1_RS19730	COG0180	Tryptophanyl-tRNA synthetase
PPYC1_RS19755	COG3093	addiction module antidote protein HigA
PPYC1_RS19770	COG2346	COG2346, Truncated hemoglobins
PPYC1_RS19775	COG3314	Sporulation integral membrane protein YlbJ
PPYC1_RS19780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PPYC1_RS19785	COG4470	Protein conserved in bacteria
PPYC1_RS19790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PPYC1_RS19795	COG0739	heme binding
PPYC1_RS19805	COG0667	Aldo Keto reductase
PPYC1_RS19810	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS19815	COG1175	transmembrane transport
PPYC1_RS19825	COG2972	Histidine kinase
PPYC1_RS19830	COG2204	response regulator
PPYC1_RS19840	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PPYC1_RS19850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PPYC1_RS19855	COG2169	Transcriptional regulator
PPYC1_RS19860	COG1115	amino acid carrier protein
PPYC1_RS19870	COG3711	transcriptional antiterminator
PPYC1_RS19875	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS19885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPYC1_RS19890	COG0569	domain protein
PPYC1_RS19900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
PPYC1_RS19905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PPYC1_RS19920	COG2197	response regulator
PPYC1_RS19925	COG4585	Histidine kinase
PPYC1_RS19935	COG1842	Phage shock protein A
PPYC1_RS19945	COG1842	Phage shock protein A
PPYC1_RS19955	COG2814	Major facilitator Superfamily
PPYC1_RS19965	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PPYC1_RS19975	COG0719	Fe-S assembly protein
PPYC1_RS19980	COG0719	Fe-S assembly protein
PPYC1_RS19985	COG0396	ATPase activity
PPYC1_RS19990	COG1846	Transcriptional regulator
PPYC1_RS20090	COG3858	chitin binding
PPYC1_RS20095	COG0735	belongs to the Fur family
PPYC1_RS20110	COG1285	pathogenesis
PPYC1_RS20115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PPYC1_RS20115	COG0456	acetyltransferase
PPYC1_RS20120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPYC1_RS20125	COG0154	amidase activity
PPYC1_RS20130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PPYC1_RS20150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPYC1_RS20160	COG0586	Pfam SNARE associated Golgi protein
PPYC1_RS20185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PPYC1_RS20195	COG4840	Belongs to the UPF0435 family
PPYC1_RS20200	COG1741	Belongs to the pirin family
PPYC1_RS20205	COG0671	phosphoesterase, PA-phosphatase related
PPYC1_RS20210	COG2261	transglycosylase associated protein
PPYC1_RS20225	COG0598	Magnesium transport protein CorA
PPYC1_RS20230	COG1191	sigma factor activity
PPYC1_RS20240	COG1366	Belongs to the anti-sigma-factor antagonist family
PPYC1_RS20250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PPYC1_RS20255	COG0784	Response regulator, receiver
PPYC1_RS20255	COG2205	protein histidine kinase activity
PPYC1_RS20255	COG5002	protein histidine kinase activity
PPYC1_RS20260	COG2208	phosphoserine phosphatase activity
PPYC1_RS20290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPYC1_RS20305	COG0488	(ABC) transporter
PPYC1_RS20310	COG1120	ATPase activity
PPYC1_RS20325	COG5386	Cell surface protein
PPYC1_RS20335	COG5386	Cell surface protein
PPYC1_RS20350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS20360	COG2329	Antibiotic biosynthesis monooxygenase
PPYC1_RS20365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PPYC1_RS20370	COG1294	oxidase, subunit
PPYC1_RS20375	COG1271	oxidase subunit
PPYC1_RS20380	COG1846	Transcriptional regulator
PPYC1_RS20385	COG2814	Major facilitator Superfamily
PPYC1_RS20390	COG1413	lyase activity
PPYC1_RS20395	COG0833	amino acid
PPYC1_RS20400	COG2211	Major facilitator Superfamily
PPYC1_RS20425	COG1070	Carbohydrate kinase
PPYC1_RS20430	COG2115	Belongs to the xylose isomerase family
PPYC1_RS20440	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS20445	COG3711	transcriptional antiterminator
PPYC1_RS20450	COG2190	(PTS) system
PPYC1_RS20450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PPYC1_RS20450	COG1263	PTS System
PPYC1_RS20475	COG0655	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS20480	COG1566	PFAM secretion protein HlyD family protein
PPYC1_RS20485	COG2814	Major facilitator Superfamily
PPYC1_RS20490	COG2217	Heavy metal translocating P-type atpase
PPYC1_RS20505	COG2217	Heavy metal translocating P-type atpase
PPYC1_RS20510	COG0640	Transcriptional regulator
PPYC1_RS20520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PPYC1_RS20530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PPYC1_RS20535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PPYC1_RS20545	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS20560	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS20565	COG4209	transmembrane transport
PPYC1_RS20575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PPYC1_RS20580	COG4988	ABC transporter
PPYC1_RS20585	COG1294	oxidase, subunit
PPYC1_RS20590	COG1271	oxidase subunit
PPYC1_RS20595	COG2207	Transcriptional regulator
PPYC1_RS20595	COG4753	response regulator
PPYC1_RS20600	COG2972	Histidine kinase
PPYC1_RS20620	COG5039	Polysaccharide pyruvyl transferase
PPYC1_RS20645	COG1253	flavin adenine dinucleotide binding
PPYC1_RS20650	COG1968	undecaprenyl-diphosphatase activity
PPYC1_RS20655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PPYC1_RS20660	COG0667	Aldo Keto reductase
PPYC1_RS20665	COG2819	hydrolase of the alpha beta superfamily
PPYC1_RS20670	COG4607	ABC-type enterochelin transport system periplasmic component
PPYC1_RS20675	COG4604	ABC transporter, ATP-binding protein
PPYC1_RS20680	COG4605	iron ion homeostasis
PPYC1_RS20685	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PPYC1_RS20700	COG0577	efflux transmembrane transporter activity
PPYC1_RS20700	COG1136	(ABC) transporter
PPYC1_RS20715	COG0346	lactoylglutathione lyase activity
PPYC1_RS20725	COG0351	phosphomethylpyrimidine kinase
PPYC1_RS20735	COG0737	Belongs to the 5'-nucleotidase family
PPYC1_RS20750	COG3639	organic phosphonate transmembrane transporter activity
PPYC1_RS20760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PPYC1_RS20765	COG4208	sulfate ABC transporter
PPYC1_RS20770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PPYC1_RS20775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PPYC1_RS20795	COG2814	Major facilitator Superfamily
PPYC1_RS20805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PPYC1_RS20815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PPYC1_RS20820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PPYC1_RS20830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PPYC1_RS20835	COG2390	Transcriptional regulator
PPYC1_RS20865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPYC1_RS20865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PPYC1_RS20880	COG1733	regulation of RNA biosynthetic process
PPYC1_RS20885	COG1733	regulation of RNA biosynthetic process
PPYC1_RS20900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PPYC1_RS20905	COG1846	Transcriptional regulator
PPYC1_RS20920	COG2249	NAD(P)H dehydrogenase (quinone) activity
PPYC1_RS20925	COG1733	regulation of RNA biosynthetic process
PPYC1_RS20930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PPYC1_RS20935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PPYC1_RS20940	COG0640	Transcriptional regulator
PPYC1_RS20950	COG2226	methyltransferase
PPYC1_RS20960	COG0596	Alpha beta hydrolase
PPYC1_RS20975	COG2814	Major facilitator Superfamily
PPYC1_RS20980	COG1819	glycosyl
PPYC1_RS20990	COG2169	Transcriptional regulator
PPYC1_RS21000	COG0456	acetyltransferase
PPYC1_RS21000	COG1846	Transcriptional regulator
PPYC1_RS21005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS21025	COG2197	response regulator
PPYC1_RS21030	COG4585	Histidine kinase
PPYC1_RS21040	COG1819	glycosyl
PPYC1_RS21060	COG1653	transport
PPYC1_RS21065	COG1609	Transcriptional regulator
PPYC1_RS21070	COG2273	Hydrolase Family 16
PPYC1_RS21080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PPYC1_RS21100	COG1132	(ABC) transporter
PPYC1_RS21105	COG1132	(ABC) transporter
PPYC1_RS21135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPYC1_RS21145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PPYC1_RS21150	COG5662	AntiSigma factor
PPYC1_RS21155	COG1595	DNA-templated transcription, initiation
PPYC1_RS21160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PPYC1_RS21260	COG0726	polysaccharide deacetylase
PPYC1_RS21270	COG0489	protein tyrosine kinase activity
PPYC1_RS21275	COG0860	N-Acetylmuramoyl-L-alanine amidase
PPYC1_RS21280	COG2046	Belongs to the sulfate adenylyltransferase family
PPYC1_RS21285	COG0175	sulfate reduction
PPYC1_RS21290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PPYC1_RS21295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PPYC1_RS21300	COG0101	tRNA pseudouridine synthase activity
PPYC1_RS21305	COG0203	ribosomal protein L17
PPYC1_RS21310	COG0202	RNA polymerase activity
PPYC1_RS21315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PPYC1_RS21320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PPYC1_RS21325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PPYC1_RS21330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PPYC1_RS21340	COG0024	Methionine aminopeptidase
PPYC1_RS21345	COG0563	adenylate kinase activity
PPYC1_RS21350	COG0201	protein transport
PPYC1_RS21355	COG0200	Binds to the 23S rRNA
PPYC1_RS21360	COG1841	ribosomal large subunit assembly
PPYC1_RS21365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PPYC1_RS21370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PPYC1_RS21375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PPYC1_RS21385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PPYC1_RS21390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PPYC1_RS21395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PPYC1_RS21400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PPYC1_RS21405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PPYC1_RS21410	COG0255	Belongs to the universal ribosomal protein uL29 family
PPYC1_RS21415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PPYC1_RS21420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PPYC1_RS21425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PPYC1_RS21440	COG0089	rRNA binding
PPYC1_RS21445	COG0088	Forms part of the polypeptide exit tunnel
PPYC1_RS21450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PPYC1_RS21470	COG0049	tRNA binding
PPYC1_RS21475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PPYC1_RS21480	COG1358	cellular component organization or biogenesis
PPYC1_RS21485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PPYC1_RS21490	COG0085	RNA polymerase activity
PPYC1_RS21495	COG2813	Specifically methylates the guanine in position
PPYC1_RS21500	COG0222	ribosome binding
PPYC1_RS21505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PPYC1_RS21510	COG0081	regulation of translation
PPYC1_RS21515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PPYC1_RS21520	COG0250	Participates in transcription elongation, termination and antitermination
PPYC1_RS21525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PPYC1_RS21530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PPYC1_RS21540	COG3688	RNA-binding protein containing a PIN domain
PPYC1_RS21545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PPYC1_RS21550	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PPYC1_RS21555	COG0215	cysteine-tRNA ligase activity
PPYC1_RS21560	COG1045	serine acetyltransferase
PPYC1_RS21565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPYC1_RS21570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PPYC1_RS21575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PPYC1_RS21580	COG4956	integral membrane protein (PIN domain superfamily)
PPYC1_RS21585	COG1183	phosphatidylcholine synthase activity
PPYC1_RS21590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PPYC1_RS21595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PPYC1_RS21600	COG0542	response to heat
PPYC1_RS21605	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PPYC1_RS21610	COG3880	PFAM UvrB UvrC protein
PPYC1_RS21645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PPYC1_RS21650	COG0210	DNA helicase
PPYC1_RS21655	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PPYC1_RS21680	COG1091	dTDP-4-dehydrorhamnose reductase activity
PPYC1_RS21695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PPYC1_RS21705	COG1216	Glycosyl transferase, family 2
PPYC1_RS21705	COG0438	transferase activity, transferring glycosyl groups
PPYC1_RS21730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PPYC1_RS21735	COG0826	peptidase U32
PPYC1_RS21745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPYC1_RS21750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS21760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PPYC1_RS21765	COG0556	nucleotide-excision repair
PPYC1_RS21770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PPYC1_RS21775	COG1360	Flagellar Motor Protein
PPYC1_RS21805	COG5297	Belongs to the glycosyl hydrolase family 6
PPYC1_RS21805	COG4733	cellulase activity
PPYC1_RS21825	COG3409	Peptidoglycan-binding domain 1 protein
PPYC1_RS21825	COG0793	Belongs to the peptidase S41A family
PPYC1_RS21830	COG0739	heme binding
PPYC1_RS21830	COG0741	lytic transglycosylase activity
PPYC1_RS21830	COG1196	nuclear chromosome segregation
PPYC1_RS21835	COG2177	Part of the ABC transporter FtsEX involved in
PPYC1_RS21840	COG2884	Cell division ATP-binding protein ftsE
PPYC1_RS21845	COG2720	vancomycin resistance protein
PPYC1_RS21875	COG0463	Glycosyl transferase, family 2
PPYC1_RS21890	COG0165	Argininosuccinate lyase
PPYC1_RS21895	COG0137	argininosuccinate synthase activity
PPYC1_RS21900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PPYC1_RS21910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PPYC1_RS21915	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PPYC1_RS21920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PPYC1_RS21925	COG3386	PFAM SMP-30 Gluconolaconase
PPYC1_RS21930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PPYC1_RS21935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PPYC1_RS21940	COG0653	protein targeting
PPYC1_RS21945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PPYC1_RS21955	COG1278	Cold shock
PPYC1_RS21965	COG1516	flagellar protein fliS
PPYC1_RS21970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PPYC1_RS21995	COG0463	Glycosyl transferase, family 2
PPYC1_RS21995	COG0457	Tetratricopeptide repeat
PPYC1_RS22000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PPYC1_RS22005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PPYC1_RS22010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PPYC1_RS22020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PPYC1_RS22025	COG1256	bacterial-type flagellum assembly
PPYC1_RS22025	COG4786	Flagellar basal body rod
PPYC1_RS22055	COG1040	competence protein
PPYC1_RS22060	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PPYC1_RS22095	COG1309	transcriptional regulator
PPYC1_RS22100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PPYC1_RS22140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PPYC1_RS22160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PPYC1_RS22165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PPYC1_RS22180	COG4786	Flagellar basal body rod
PPYC1_RS22190	COG1609	Transcriptional regulator
PPYC1_RS22195	COG0739	heme binding
PPYC1_RS22200	COG2385	sporulation resulting in formation of a cellular spore
PPYC1_RS22205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PPYC1_RS22220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PPYC1_RS22225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PPYC1_RS22230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PPYC1_RS22235	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PPYC1_RS22240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PPYC1_RS22245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PPYC1_RS22255	COG0356	it plays a direct role in the translocation of protons across the membrane
PPYC1_RS22270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PPYC1_RS22275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PPYC1_RS22295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PPYC1_RS22300	COG4475	Protein of unknown function (DUF436)
PPYC1_RS22310	COG1971	Probably functions as a manganese efflux pump
PPYC1_RS22315	COG0009	L-threonylcarbamoyladenylate synthase
PPYC1_RS22325	COG0772	Belongs to the SEDS family
PPYC1_RS22330	COG2890	protein-(glutamine-N5) methyltransferase activity
PPYC1_RS22335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PPYC1_RS22340	COG0012	GTP binding
PPYC1_RS22345	COG0456	acetyltransferase
PPYC1_RS22350	COG1304	FMN binding
PPYC1_RS22375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PPYC1_RS22385	COG2076	Multidrug Resistance protein
PPYC1_RS22390	COG2076	Multidrug Resistance protein
PPYC1_RS22400	COG1522	sequence-specific DNA binding
PPYC1_RS22415	COG1279	arginine transmembrane transporter activity
PPYC1_RS22420	COG0746	molybdenum cofactor guanylyltransferase activity
PPYC1_RS22430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PPYC1_RS22450	COG2814	Major facilitator Superfamily
PPYC1_RS22455	COG0243	molybdopterin cofactor binding
PPYC1_RS22470	COG0446	pyridine nucleotide-disulphide oxidoreductase
PPYC1_RS22475	COG0386	Belongs to the glutathione peroxidase family
PPYC1_RS22485	COG1120	ATPase activity
PPYC1_RS22490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS22495	COG0628	permease
PPYC1_RS22500	COG1316	TRANSCRIPTIONal
PPYC1_RS22505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PPYC1_RS22595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS22600	COG1126	abc transporter atp-binding protein
PPYC1_RS22605	COG0765	amino acid transport
PPYC1_RS22610	COG0765	amino acid transport
PPYC1_RS22615	COG0659	secondary active sulfate transmembrane transporter activity
PPYC1_RS22635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PPYC1_RS22650	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS22680	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
PPYC1_RS22705	COG1611	Belongs to the LOG family
PPYC1_RS22710	COG1587	Uroporphyrinogen-III synthase
PPYC1_RS22715	COG0531	amino acid
PPYC1_RS22730	COG0697	spore germination
PPYC1_RS22750	COG0697	spore germination
PPYC1_RS22755	COG0840	transmembrane signaling receptor activity
PPYC1_RS22760	COG2259	Doxx family
PPYC1_RS22775	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS22795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PPYC1_RS22805	COG0697	spore germination
PPYC1_RS22815	COG3706	GGDEF domain
PPYC1_RS22825	COG1472	Belongs to the glycosyl hydrolase 3 family
PPYC1_RS22830	COG2002	toxin-antitoxin pair type II binding
PPYC1_RS22845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PPYC1_RS22870	COG0300	oxidoreductase activity
PPYC1_RS22885	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PPYC1_RS22890	COG0783	Belongs to the Dps family
PPYC1_RS22895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PPYC1_RS22900	COG3842	ATPase activity
PPYC1_RS22910	COG1176	ABC-type spermidine putrescine transport system, permease component I
PPYC1_RS22975	COG0791	NLP P60 protein
PPYC1_RS22995	COG2205	protein histidine kinase activity
PPYC1_RS22995	COG0784	Response regulator, receiver
PPYC1_RS23015	COG1846	Transcriptional regulator
PPYC1_RS23025	COG3706	GGDEF domain
PPYC1_RS23035	COG0583	DNA-binding transcription factor activity
PPYC1_RS23040	COG1380	Effector of murein hydrolase LrgA
PPYC1_RS23045	COG1346	cytolysis
PPYC1_RS23050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PPYC1_RS23060	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PPYC1_RS23070	COG2910	NAD(P)H-binding
PPYC1_RS23075	COG0475	glutathione-regulated potassium exporter activity
PPYC1_RS23090	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS23095	COG2807	transmembrane transport
PPYC1_RS23100	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS23105	COG0800	Aldolase
PPYC1_RS23110	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PPYC1_RS23115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PPYC1_RS23120	COG1609	Transcriptional regulator
PPYC1_RS23125	COG0534	Mate efflux family protein
PPYC1_RS23130	COG0604	alcohol dehydrogenase
PPYC1_RS23135	COG1595	DNA-templated transcription, initiation
PPYC1_RS23145	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS23150	COG1175	transmembrane transport
PPYC1_RS23155	COG1653	transport
PPYC1_RS23165	COG1131	(ABC) transporter
PPYC1_RS23170	COG0488	(ABC) transporter
PPYC1_RS23175	COG2814	Major facilitator Superfamily
PPYC1_RS23180	COG3458	cephalosporin-C deacetylase activity
PPYC1_RS23185	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
PPYC1_RS23190	COG0395	ABC-type sugar transport system, permease component
PPYC1_RS23195	COG1175	transmembrane transport
PPYC1_RS23200	COG2182	Extracellular solute-binding protein
PPYC1_RS23205	COG2942	2-epimerase
PPYC1_RS23210	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
PPYC1_RS23215	COG1609	Transcriptional regulator
PPYC1_RS23225	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
PPYC1_RS23245	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS23250	COG1252	NADH dehydrogenase
PPYC1_RS23275	COG0588	phosphoglycerate mutase activity
PPYC1_RS23295	COG1609	Transcriptional regulator
PPYC1_RS23300	COG2195	Cleaves the N-terminal amino acid of tripeptides
PPYC1_RS23305	COG0840	transmembrane signaling receptor activity
PPYC1_RS23315	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PPYC1_RS23320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PPYC1_RS23325	COG3693	PFAM glycoside hydrolase, family 10
PPYC1_RS23345	COG3275	phosphorelay sensor kinase activity
PPYC1_RS23350	COG2207	Transcriptional regulator
PPYC1_RS23350	COG4753	response regulator
PPYC1_RS23370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PPYC1_RS23375	COG1773	rubredoxin
PPYC1_RS23380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PPYC1_RS23390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PPYC1_RS23405	COG0702	epimerase
PPYC1_RS23410	COG1309	transcriptional regulator
PPYC1_RS23415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PPYC1_RS23420	COG0390	transport system, permease component
PPYC1_RS23465	COG1522	sequence-specific DNA binding
PPYC1_RS23470	COG2814	Major facilitator Superfamily
PPYC1_RS23475	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS23495	COG1874	Beta-galactosidase
PPYC1_RS23495	COG0366	Alpha amylase catalytic
PPYC1_RS23500	COG1902	pentaerythritol trinitrate reductase activity
PPYC1_RS23510	COG2207	Transcriptional regulator
PPYC1_RS23510	COG4753	response regulator
PPYC1_RS23515	COG2972	Histidine kinase
PPYC1_RS23530	COG0840	transmembrane signaling receptor activity
PPYC1_RS23530	COG3290	protein histidine kinase activity
PPYC1_RS23535	COG0523	cobalamin synthesis protein
PPYC1_RS23555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PPYC1_RS23565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PPYC1_RS23565	COG2755	lipolytic protein G-D-S-L family
PPYC1_RS23570	COG0733	neurotransmitter:sodium symporter activity
PPYC1_RS23605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PPYC1_RS23620	COG2188	Transcriptional regulator
PPYC1_RS23625	COG2723	6-phospho-beta-galactosidase activity
PPYC1_RS23630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPYC1_RS23635	COG1447	Phosphotransferase system cellobiose-specific component IIA
PPYC1_RS23640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PPYC1_RS23670	COG4166	transmembrane transport
PPYC1_RS23690	COG2378	regulation of single-species biofilm formation
PPYC1_RS23695	COG0673	inositol 2-dehydrogenase activity
PPYC1_RS23700	COG0252	asparaginase activity
PPYC1_RS23705	COG1126	abc transporter atp-binding protein
PPYC1_RS23710	COG0765	amino acid transport
PPYC1_RS23715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PPYC1_RS23720	COG1124	(ABC) transporter
PPYC1_RS23730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS23735	COG0601	transmembrane transport
PPYC1_RS23740	COG0747	negative chemotaxis
PPYC1_RS23750	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS23755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS23760	COG0601	transmembrane transport
PPYC1_RS23765	COG0747	negative chemotaxis
PPYC1_RS23770	COG2233	PERMEase
PPYC1_RS23775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PPYC1_RS23785	COG4806	L-rhamnose isomerase
PPYC1_RS23790	COG0235	Class ii aldolase
PPYC1_RS23795	COG0662	Cupin 2, conserved barrel domain protein
PPYC1_RS23795	COG2207	Transcriptional regulator
PPYC1_RS23805	COG2040	homocysteine
PPYC1_RS23815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PPYC1_RS23820	COG4565	transcriptional regulatory protein
PPYC1_RS23825	COG3290	protein histidine kinase activity
PPYC1_RS23835	COG0167	dihydroorotate dehydrogenase activity
PPYC1_RS23840	COG0543	2 iron, 2 sulfur cluster binding
PPYC1_RS23845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PPYC1_RS23855	COG2207	Transcriptional regulator
PPYC1_RS23855	COG3708	Transcriptional regulator
PPYC1_RS23860	COG0583	DNA-binding transcription factor activity
PPYC1_RS23865	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS23875	COG1733	regulation of RNA biosynthetic process
PPYC1_RS23880	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS23890	COG0386	Belongs to the glutathione peroxidase family
PPYC1_RS23900	COG1028	Short-chain dehydrogenase reductase Sdr
PPYC1_RS23920	COG0322	excinuclease ABC activity
PPYC1_RS23935	COG0028	Belongs to the TPP enzyme family
PPYC1_RS23935	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PPYC1_RS23940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PPYC1_RS23960	COG0667	Aldo Keto reductase
PPYC1_RS23985	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS23990	COG2205	protein histidine kinase activity
PPYC1_RS23995	COG1136	(ABC) transporter
PPYC1_RS24000	COG0577	efflux transmembrane transporter activity
PPYC1_RS24015	COG0667	Aldo Keto reductase
PPYC1_RS24020	COG0535	radical SAM domain protein
PPYC1_RS24035	COG2210	Belongs to the sulfur carrier protein TusA family
PPYC1_RS24050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PPYC1_RS24060	COG2824	Alkylphosphonate utilization operon protein PhnA
PPYC1_RS24065	COG0702	epimerase
PPYC1_RS24070	COG1597	lipid kinase activity
PPYC1_RS24080	COG4589	Belongs to the CDS family
PPYC1_RS24085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PPYC1_RS24090	COG0697	spore germination
PPYC1_RS24095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS24095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS24095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PPYC1_RS24100	COG3711	transcriptional antiterminator
PPYC1_RS24100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PPYC1_RS24120	COG3835	regulator
PPYC1_RS24125	COG1929	Belongs to the glycerate kinase type-1 family
PPYC1_RS24130	COG2610	gluconate transmembrane transporter activity
PPYC1_RS24150	COG3693	PFAM glycoside hydrolase, family 10
PPYC1_RS24155	COG0657	acetylesterase activity
PPYC1_RS24165	COG1309	transcriptional regulator
PPYC1_RS24200	COG0494	nUDIX hydrolase
PPYC1_RS24205	COG4221	oxidoreductase activity
PPYC1_RS24210	COG0579	oxidoreductase
PPYC1_RS24225	COG2160	L-arabinose isomerase activity
PPYC1_RS24230	COG0235	Class ii aldolase
PPYC1_RS24240	COG1609	Transcriptional regulator
PPYC1_RS24250	COG0702	epimerase
PPYC1_RS24265	COG1309	transcriptional regulator
PPYC1_RS24270	COG2353	YceI-like domain
PPYC1_RS24280	COG0477	Major facilitator Superfamily
PPYC1_RS24305	COG3693	PFAM glycoside hydrolase, family 10
PPYC1_RS24305	COG3507	Belongs to the glycosyl hydrolase 43 family
PPYC1_RS24305	COG2382	esterase
PPYC1_RS24335	COG2207	Transcriptional regulator
PPYC1_RS24335	COG3708	Transcriptional regulator
PPYC1_RS24340	COG2207	Transcriptional regulator
PPYC1_RS24340	COG3708	Transcriptional regulator
PPYC1_RS24365	COG1396	sequence-specific DNA binding
PPYC1_RS24395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PPYC1_RS24405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PPYC1_RS24420	COG5002	protein histidine kinase activity
PPYC1_RS24425	COG0745	RESPONSE REGULATOR receiver
PPYC1_RS24430	COG0739	heme binding
PPYC1_RS24440	COG2188	Transcriptional regulator
PPYC1_RS24445	COG0587	DNA-directed DNA polymerase activity
PPYC1_RS24470	COG3842	ATPase activity
PPYC1_RS24480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PPYC1_RS24485	COG0305	Participates in initiation and elongation during chromosome replication
PPYC1_RS24490	COG0359	binds to the 23S rRNA
PPYC1_RS24495	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PPYC1_RS24525	COG4608	Belongs to the ABC transporter superfamily
PPYC1_RS24530	COG0444	Belongs to the ABC transporter superfamily
PPYC1_RS24535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PPYC1_RS24540	COG0601	transmembrane transport
PPYC1_RS24545	COG4166	transmembrane transport
PPYC1_RS24550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PPYC1_RS24555	COG0629	single-stranded DNA binding
PPYC1_RS24560	COG0360	Binds together with S18 to 16S ribosomal RNA
PPYC1_RS24580	COG4481	Protein conserved in bacteria
PPYC1_RS24585	COG0668	transmembrane transport
PPYC1_RS24600	COG1475	DNA binding
PPYC1_RS24605	COG1192	Involved in chromosome partitioning
PPYC1_RS24610	COG1475	DNA binding
PPYC1_RS24615	COG0357	Ribosomal RNA small subunit methyltransferase G
PPYC1_RS24620	COG0445	tRNA wobble uridine modification
PPYC1_RS24625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PPYC1_RS24630	COG1847	R3H domain protein
PPYC1_RS24640	COG0594	ribonuclease P activity
PPYC1_RS24645	COG0230	Belongs to the bacterial ribosomal protein bL34 family