locus-tag	class	description
GZH47_RS00040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH47_RS00055	COG2205	protein histidine kinase activity
GZH47_RS00060	COG0745	RESPONSE REGULATOR receiver
GZH47_RS00070	COG2608	mercury ion transmembrane transporter activity
GZH47_RS00080	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS00085	COG0702	epimerase
GZH47_RS00090	COG1959	2 iron, 2 sulfur cluster binding
GZH47_RS00095	COG0300	oxidoreductase activity
GZH47_RS00100	COG1902	pentaerythritol trinitrate reductase activity
GZH47_RS00105	COG1063	alcohol dehydrogenase
GZH47_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS00120	COG1733	regulation of RNA biosynthetic process
GZH47_RS00180	COG1733	regulation of RNA biosynthetic process
GZH47_RS00205	COG0697	spore germination
GZH47_RS00285	COG2197	response regulator
GZH47_RS00290	COG0784	Response regulator, receiver
GZH47_RS00290	COG3437	response regulator, receiver
GZH47_RS00320	COG0456	acetyltransferase
GZH47_RS00340	COG0693	protein deglycase activity
GZH47_RS00340	COG0753	catalase activity
GZH47_RS00375	COG4251	negative regulation of phosphorylation
GZH47_RS00375	COG5001	Diguanylate cyclase
GZH47_RS00375	COG2203	Gaf domain
GZH47_RS00375	COG3706	GGDEF domain
GZH47_RS00380	COG0697	spore germination
GZH47_RS00395	COG5002	protein histidine kinase activity
GZH47_RS00400	COG2207	Transcriptional regulator
GZH47_RS00405	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS00430	COG5002	protein histidine kinase activity
GZH47_RS00430	COG3850	Histidine kinase
GZH47_RS00435	COG0745	RESPONSE REGULATOR receiver
GZH47_RS00455	COG2323	membrane
GZH47_RS00460	COG2814	Major facilitator Superfamily
GZH47_RS00475	COG4221	oxidoreductase activity
GZH47_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZH47_RS00500	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS00505	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GZH47_RS00510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH47_RS00515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZH47_RS00520	COG2351	hydroxyisourate hydrolase activity
GZH47_RS00530	COG3648	Uricase
GZH47_RS00530	COG3195	allantoin biosynthetic process
GZH47_RS00535	COG2080	2 iron, 2 sulfur cluster binding
GZH47_RS00540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GZH47_RS00555	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GZH47_RS00560	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS00605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS00615	COG0655	NAD(P)H dehydrogenase (quinone) activity
GZH47_RS00620	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS00630	COG2508	Transcriptional regulator
GZH47_RS00635	COG0405	Gamma-glutamyltransferase
GZH47_RS00650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZH47_RS00715	COG1132	(ABC) transporter
GZH47_RS00745	COG1309	transcriptional regulator
GZH47_RS00760	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GZH47_RS00765	COG0561	phosphatase activity
GZH47_RS00770	COG1349	DNA-binding transcription factor activity
GZH47_RS00795	COG1361	Conserved repeat domain
GZH47_RS00805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZH47_RS00810	COG2814	Major facilitator Superfamily
GZH47_RS00835	COG1132	(ABC) transporter
GZH47_RS00840	COG1132	(ABC) transporter
GZH47_RS00855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH47_RS00875	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS00880	COG2972	Histidine kinase
GZH47_RS00885	COG2207	Transcriptional regulator
GZH47_RS00920	COG0395	ABC-type sugar transport system, permease component
GZH47_RS00935	COG3842	ATPase activity
GZH47_RS00940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZH47_RS00950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH47_RS00960	COG1132	(ABC) transporter
GZH47_RS00980	COG2814	Major facilitator Superfamily
GZH47_RS01030	COG0395	ABC-type sugar transport system, permease component
GZH47_RS01035	COG1175	transmembrane transport
GZH47_RS01050	COG5002	protein histidine kinase activity
GZH47_RS01055	COG0745	RESPONSE REGULATOR receiver
GZH47_RS01060	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS01065	COG0583	DNA-binding transcription factor activity
GZH47_RS01070	COG2814	Major facilitator Superfamily
GZH47_RS01090	COG0488	(ABC) transporter
GZH47_RS01095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GZH47_RS01110	COG1595	DNA-templated transcription, initiation
GZH47_RS01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZH47_RS01125	COG0392	lysyltransferase activity
GZH47_RS01125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GZH47_RS01135	COG1937	Protein conserved in bacteria
GZH47_RS01140	COG2210	Belongs to the sulfur carrier protein TusA family
GZH47_RS01145	COG0425	Belongs to the sulfur carrier protein TusA family
GZH47_RS01150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH47_RS01150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS01155	COG0425	Belongs to the sulfur carrier protein TusA family
GZH47_RS01155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH47_RS01160	COG0730	response to heat
GZH47_RS01175	COG0745	RESPONSE REGULATOR receiver
GZH47_RS01180	COG5002	protein histidine kinase activity
GZH47_RS01185	COG1073	alpha beta
GZH47_RS01210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZH47_RS01215	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GZH47_RS01275	COG3546	catalase activity
GZH47_RS01295	COG2814	Major facilitator Superfamily
GZH47_RS01315	COG1725	Transcriptional regulator
GZH47_RS01325	COG1131	(ABC) transporter
GZH47_RS01345	COG0697	spore germination
GZH47_RS01365	COG0697	spore germination
GZH47_RS01400	COG0583	DNA-binding transcription factor activity
GZH47_RS01415	COG1131	(ABC) transporter
GZH47_RS01420	COG4585	Histidine kinase
GZH47_RS01425	COG2197	response regulator
GZH47_RS01495	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS01515	COG0745	RESPONSE REGULATOR receiver
GZH47_RS01525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS01555	COG0477	Major facilitator Superfamily
GZH47_RS01560	COG1309	transcriptional regulator
GZH47_RS01595	COG0697	spore germination
GZH47_RS01610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZH47_RS01630	COG2721	sulfolactate sulfo-lyase activity
GZH47_RS01645	COG0346	lactoylglutathione lyase activity
GZH47_RS01665	COG0628	permease
GZH47_RS01670	COG1278	Cold shock
GZH47_RS01675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZH47_RS01680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZH47_RS01700	COG1733	regulation of RNA biosynthetic process
GZH47_RS01765	COG3852	Histidine kinase
GZH47_RS01775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS01780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZH47_RS01785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH47_RS01790	COG1063	alcohol dehydrogenase
GZH47_RS01800	COG0583	DNA-binding transcription factor activity
GZH47_RS01805	COG1011	Hydrolase
GZH47_RS01810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GZH47_RS01815	COG1959	2 iron, 2 sulfur cluster binding
GZH47_RS01820	COG0010	Belongs to the arginase family
GZH47_RS01825	COG1228	amidohydrolase
GZH47_RS01835	COG2986	histidine ammonia-lyase
GZH47_RS01840	COG0753	catalase activity
GZH47_RS01875	COG1842	Phage shock protein A
GZH47_RS01885	COG5002	protein histidine kinase activity
GZH47_RS01890	COG0745	RESPONSE REGULATOR receiver
GZH47_RS01905	COG0395	ABC-type sugar transport system, permease component
GZH47_RS01910	COG4209	transmembrane transport
GZH47_RS01920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZH47_RS01925	COG2971	BadF BadG BcrA BcrD
GZH47_RS01930	COG3876	Protein conserved in bacteria
GZH47_RS01940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZH47_RS01945	COG1737	Transcriptional regulator
GZH47_RS01955	COG0784	Response regulator, receiver
GZH47_RS01960	COG4191	Histidine kinase
GZH47_RS01965	COG0765	amino acid transport
GZH47_RS01970	COG0765	amino acid transport
GZH47_RS01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH47_RS01995	COG1309	transcriptional regulator
GZH47_RS02010	COG2323	membrane
GZH47_RS02035	COG0697	spore germination
GZH47_RS02040	COG0531	amino acid
GZH47_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZH47_RS02095	COG2602	Beta-lactamase
GZH47_RS02110	COG3850	Histidine kinase
GZH47_RS02110	COG5002	protein histidine kinase activity
GZH47_RS02115	COG0745	RESPONSE REGULATOR receiver
GZH47_RS02150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZH47_RS02155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GZH47_RS02160	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS02165	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS02180	COG0346	lactoylglutathione lyase activity
GZH47_RS02210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZH47_RS02215	COG2720	vancomycin resistance protein
GZH47_RS02225	COG5002	protein histidine kinase activity
GZH47_RS02230	COG0574	Belongs to the PEP-utilizing enzyme family
GZH47_RS02230	COG3848	Pyruvate phosphate dikinase
GZH47_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZH47_RS02255	COG0723	plastoquinol--plastocyanin reductase activity
GZH47_RS02260	COG2409	Drug exporters of the RND superfamily
GZH47_RS02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GZH47_RS02285	COG2814	Major facilitator Superfamily
GZH47_RS02295	COG0596	Alpha beta hydrolase
GZH47_RS02300	COG2378	regulation of single-species biofilm formation
GZH47_RS02315	COG0673	inositol 2-dehydrogenase activity
GZH47_RS02330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZH47_RS02335	COG3153	acetyltransferase
GZH47_RS02355	COG2816	NAD+ diphosphatase activity
GZH47_RS02415	COG1216	Glycosyl transferase, family 2
GZH47_RS02425	COG0277	FAD linked oxidase domain protein
GZH47_RS02430	COG1132	(ABC) transporter
GZH47_RS02440	COG1132	(ABC) transporter
GZH47_RS02445	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GZH47_RS02455	COG0640	Transcriptional regulator
GZH47_RS02470	COG2409	Drug exporters of the RND superfamily
GZH47_RS02485	COG5434	Belongs to the glycosyl hydrolase 28 family
GZH47_RS02485	COG4632	Exopolysaccharide biosynthesis protein
GZH47_RS02490	COG0667	Aldo Keto reductase
GZH47_RS02505	COG0667	Aldo Keto reductase
GZH47_RS02515	COG3739	integral membrane protein
GZH47_RS02520	COG0701	Predicted permease
GZH47_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS02580	COG0673	inositol 2-dehydrogenase activity
GZH47_RS02600	COG0697	spore germination
GZH47_RS02610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZH47_RS02640	COG1876	peptidase activity
GZH47_RS02655	COG0395	ABC-type sugar transport system, permease component
GZH47_RS02660	COG1175	transmembrane transport
GZH47_RS02675	COG1024	Enoyl-CoA hydratase
GZH47_RS02680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZH47_RS02685	COG1960	acyl-CoA dehydrogenase activity
GZH47_RS02700	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS02710	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS02720	COG0745	RESPONSE REGULATOR receiver
GZH47_RS02725	COG5002	protein histidine kinase activity
GZH47_RS02725	COG3850	Histidine kinase
GZH47_RS02745	COG0697	spore germination
GZH47_RS02750	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GZH47_RS02755	COG0709	Synthesizes selenophosphate from selenide and ATP
GZH47_RS02765	COG3239	Fatty acid desaturase
GZH47_RS02775	COG1278	Cold shock
GZH47_RS02780	COG4974	Belongs to the 'phage' integrase family
GZH47_RS02805	COG1595	DNA-templated transcription, initiation
GZH47_RS02810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZH47_RS02815	COG0725	ABC transporter, periplasmic molybdate-binding protein
GZH47_RS02820	COG4149	molybdate abc transporter
GZH47_RS02830	COG2801	Transposase and inactivated derivatives
GZH47_RS02835	COG4124	Belongs to the glycosyl hydrolase 26 family
GZH47_RS02840	COG0778	Nitroreductase
GZH47_RS02845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZH47_RS02855	COG1131	(ABC) transporter
GZH47_RS02880	COG2205	protein histidine kinase activity
GZH47_RS02895	COG0493	'glutamate synthase
GZH47_RS02895	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GZH47_RS02900	COG0069	glutamate synthase activity
GZH47_RS02910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZH47_RS02915	COG0583	DNA-binding transcription factor activity
GZH47_RS02920	COG0436	Aminotransferase
GZH47_RS02935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GZH47_RS02940	COG1845	cytochrome c oxidase, subunit III
GZH47_RS02945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZH47_RS02960	COG1846	Transcriptional regulator
GZH47_RS02965	COG0243	molybdopterin cofactor binding
GZH47_RS02980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZH47_RS02995	COG0395	ABC-type sugar transport system, permease component
GZH47_RS03000	COG4209	transmembrane transport
GZH47_RS03035	COG2223	nitrite transmembrane transporter activity
GZH47_RS03040	COG1119	ATPase activity
GZH47_RS03055	COG1595	DNA-templated transcription, initiation
GZH47_RS03060	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GZH47_RS03080	COG1910	domain protein
GZH47_RS03125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH47_RS03135	COG3153	acetyltransferase
GZH47_RS03135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZH47_RS03150	COG1011	Hydrolase
GZH47_RS03155	COG0277	FAD linked oxidase domain protein
GZH47_RS03180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZH47_RS03185	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS03190	COG1247	-acetyltransferase
GZH47_RS03195	COG0395	ABC-type sugar transport system, permease component
GZH47_RS03200	COG1175	transmembrane transport
GZH47_RS03205	COG1653	transport
GZH47_RS03210	COG4753	response regulator
GZH47_RS03210	COG2207	Transcriptional regulator
GZH47_RS03215	COG2972	Histidine kinase
GZH47_RS03220	COG0673	inositol 2-dehydrogenase activity
GZH47_RS03255	COG0395	ABC-type sugar transport system, permease component
GZH47_RS03260	COG4209	transmembrane transport
GZH47_RS03265	COG1653	transport
GZH47_RS03275	COG2972	Histidine kinase
GZH47_RS03325	COG0398	Pfam SNARE associated Golgi protein
GZH47_RS03335	COG3973	AAA domain
GZH47_RS03340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZH47_RS03345	COG0583	DNA-binding transcription factor activity
GZH47_RS03350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZH47_RS03355	COG5002	protein histidine kinase activity
GZH47_RS03360	COG0745	RESPONSE REGULATOR receiver
GZH47_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS03370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH47_RS03380	COG2205	protein histidine kinase activity
GZH47_RS03390	COG3973	AAA domain
GZH47_RS03395	COG0159	tryptophan synthase activity
GZH47_RS03400	COG0133	tryptophan synthase activity
GZH47_RS03415	COG1643	Atp-dependent helicase
GZH47_RS03425	COG1492	cobalamin metabolic process
GZH47_RS03430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZH47_RS03435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GZH47_RS03440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GZH47_RS03445	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GZH47_RS03450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GZH47_RS03455	COG1120	ATPase activity
GZH47_RS03460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS03465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS03470	COG2217	Heavy metal translocating P-type atpase
GZH47_RS03475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH47_RS03490	COG0681	Belongs to the peptidase S26 family
GZH47_RS03495	COG2814	Major facilitator Superfamily
GZH47_RS03500	COG4550	Control of competence regulator ComK, YlbF/YmcA
GZH47_RS03505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZH47_RS03510	COG4869	propanediol catabolic process
GZH47_RS03515	COG1013	pyruvate-flavodoxin oxidoreductase activity
GZH47_RS03520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GZH47_RS03520	COG0674	pyruvate-flavodoxin oxidoreductase activity
GZH47_RS03530	COG2359	stage V sporulation protein S
GZH47_RS03535	COG1692	metallophosphoesterase
GZH47_RS03540	COG1418	mRNA catabolic process
GZH47_RS03545	COG2137	regulation of response to DNA damage stimulus
GZH47_RS03550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZH47_RS03555	COG1546	Belongs to the CinA family
GZH47_RS03555	COG1058	Belongs to the CinA family
GZH47_RS03560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZH47_RS03565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZH47_RS03575	COG1426	Protein conserved in bacteria
GZH47_RS03590	COG0300	oxidoreductase activity
GZH47_RS03595	COG0612	Peptidase, M16
GZH47_RS03600	COG0612	Peptidase, M16
GZH47_RS03620	COG0740	serine-type endopeptidase activity
GZH47_RS03625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZH47_RS03630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH47_RS03635	COG0527	aspartate kinase activity
GZH47_RS03640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZH47_RS03645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZH47_RS03650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH47_RS03655	COG0756	dUTP diphosphatase activity
GZH47_RS03660	COG0612	Peptidase, M16
GZH47_RS03665	COG0726	polysaccharide deacetylase
GZH47_RS03670	COG1185	polyribonucleotide nucleotidyltransferase activity
GZH47_RS03675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZH47_RS03680	COG0196	riboflavin kinase activity
GZH47_RS03685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZH47_RS03690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZH47_RS03695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZH47_RS03700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZH47_RS03710	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GZH47_RS03715	COG0195	Participates in both transcription termination and antitermination
GZH47_RS03720	COG0779	Required for maturation of 30S ribosomal subunits
GZH47_RS03725	COG2176	DNA-directed DNA polymerase activity
GZH47_RS03730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZH47_RS03735	COG0750	zinc metalloprotease
GZH47_RS03740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZH47_RS03745	COG4589	Belongs to the CDS family
GZH47_RS03750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GZH47_RS03755	COG0233	cytoplasmic translational termination
GZH47_RS03760	COG0528	UMP kinase activity
GZH47_RS03765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZH47_RS03770	COG0052	Belongs to the universal ribosomal protein uS2 family
GZH47_RS03795	COG1191	sigma factor activity
GZH47_RS03805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GZH47_RS03810	COG1776	CheC inhibitor of MCP methylation
GZH47_RS03815	COG0835	chemotaxis
GZH47_RS03820	COG0643	Histidine kinase
GZH47_RS03820	COG2198	Histidine kinase
GZH47_RS03825	COG2201	protein-glutamate methylesterase activity
GZH47_RS03830	COG0455	bacterial-type flagellum organization
GZH47_RS03835	COG1419	protein localization to endoplasmic reticulum
GZH47_RS03840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZH47_RS03845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZH47_RS03850	COG1684	flagellar biosynthetic protein fliR
GZH47_RS03855	COG1987	bacterial-type flagellum assembly
GZH47_RS03860	COG1338	Plays a role in the flagellum-specific transport system
GZH47_RS03870	COG2201	protein-glutamate methylesterase activity
GZH47_RS03875	COG1776	CheC inhibitor of MCP methylation
GZH47_RS03875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZH47_RS03880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZH47_RS03895	COG4786	Flagellar basal body rod
GZH47_RS03905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GZH47_RS03925	COG1157	protein secretion by the type III secretion system
GZH47_RS03935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GZH47_RS03940	COG1766	The M ring may be actively involved in energy transduction
GZH47_RS03945	COG1677	Flagellar hook-basal body complex protein FliE
GZH47_RS03950	COG1558	bacterial-type flagellum-dependent cell motility
GZH47_RS03955	COG1815	bacterial-type flagellum-dependent cell motility
GZH47_RS03965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZH47_RS03970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZH47_RS03975	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GZH47_RS03980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZH47_RS03985	COG0758	DNA mediated transformation
GZH47_RS03990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GZH47_RS03995	COG0045	succinate-CoA ligase (ADP-forming) activity
GZH47_RS04010	COG0792	nuclease activity
GZH47_RS04015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GZH47_RS04025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZH47_RS04030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZH47_RS04040	COG0335	large ribosomal subunit rRNA binding
GZH47_RS04050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZH47_RS04060	COG0228	four-way junction DNA binding
GZH47_RS04065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZH47_RS04070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GZH47_RS04075	COG0552	protein localization to endoplasmic reticulum
GZH47_RS04080	COG1196	nuclear chromosome segregation
GZH47_RS04085	COG0571	ribonuclease III activity
GZH47_RS04090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZH47_RS04095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZH47_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS04105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZH47_RS04115	COG0416	fatty acid biosynthetic process
GZH47_RS04125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZH47_RS04130	COG1399	metal-binding, possibly nucleic acid-binding protein
GZH47_RS04135	COG1323	Belongs to the UPF0348 family
GZH47_RS04140	COG3314	Sporulation integral membrane protein YlbJ
GZH47_RS04145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GZH47_RS04150	COG0742	ribosomal rna small subunit methyltransferase
GZH47_RS04155	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS04160	COG0444	Belongs to the ABC transporter superfamily
GZH47_RS04165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS04170	COG0601	transmembrane transport
GZH47_RS04175	COG4166	transmembrane transport
GZH47_RS04180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZH47_RS04185	COG1346	cytolysis
GZH47_RS04195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH47_RS04215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZH47_RS04220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZH47_RS04225	COG1063	alcohol dehydrogenase
GZH47_RS04230	COG0667	Aldo Keto reductase
GZH47_RS04235	COG0667	Aldo Keto reductase
GZH47_RS04245	COG2207	Transcriptional regulator
GZH47_RS04250	COG0563	adenylate kinase activity
GZH47_RS04275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH47_RS04285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZH47_RS04300	COG1705	Flagellar rod assembly protein muramidase FlgJ
GZH47_RS04305	COG3069	C4-dicarboxylate transmembrane transporter activity
GZH47_RS04310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS04315	COG0735	belongs to the Fur family
GZH47_RS04325	COG3935	DnaD domain protein
GZH47_RS04330	COG0017	Asparaginyl-tRNA synthetase
GZH47_RS04335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZH47_RS04340	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZH47_RS04360	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS04365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZH47_RS04370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZH47_RS04370	COG1199	ATP-dependent helicase activity
GZH47_RS04385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GZH47_RS04390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GZH47_RS04400	COG0617	tRNA 3'-terminal CCA addition
GZH47_RS04405	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS04410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZH47_RS04415	COG1803	Methylglyoxal synthase
GZH47_RS04430	COG1694	Mazg nucleotide pyrophosphohydrolase
GZH47_RS04435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH47_RS04445	COG4347	Protein of unknown function (DUF1405)
GZH47_RS04455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZH47_RS04480	COG0588	phosphoglycerate mutase activity
GZH47_RS04495	COG0287	Prephenate dehydrogenase
GZH47_RS04500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZH47_RS04505	COG0159	tryptophan synthase activity
GZH47_RS04510	COG0133	tryptophan synthase activity
GZH47_RS04515	COG0135	phosphoribosylanthranilate isomerase activity
GZH47_RS04520	COG0134	indole-3-glycerol-phosphate synthase activity
GZH47_RS04525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GZH47_RS04540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZH47_RS04545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZH47_RS04550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZH47_RS04560	COG0142	geranyltranstransferase activity
GZH47_RS04565	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GZH47_RS04570	COG0163	prenyltransferase activity
GZH47_RS04575	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GZH47_RS04580	COG2226	methyltransferase
GZH47_RS04605	COG0776	regulation of translation
GZH47_RS04610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZH47_RS04645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZH47_RS04650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZH47_RS04655	COG1160	GTP binding
GZH47_RS04700	COG2959	enzyme of heme biosynthesis
GZH47_RS04710	COG2339	peptidase activity
GZH47_RS04715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GZH47_RS04720	COG4862	establishment of competence for transformation
GZH47_RS04735	COG1408	metallophosphoesterase
GZH47_RS04755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH47_RS04760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZH47_RS04770	COG5002	protein histidine kinase activity
GZH47_RS04775	COG0745	RESPONSE REGULATOR receiver
GZH47_RS04780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZH47_RS04785	COG1333	cytochrome c biogenesis protein
GZH47_RS04790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS04795	COG1187	pseudouridine synthase activity
GZH47_RS04800	COG0700	Nucleoside recognition
GZH47_RS04805	COG2715	membrane protein required for spore maturation
GZH47_RS04810	COG1686	Belongs to the peptidase S11 family
GZH47_RS04815	COG3874	Sporulation protein YtfJ
GZH47_RS04825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZH47_RS04830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZH47_RS04835	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GZH47_RS04840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH47_RS04840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH47_RS04850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZH47_RS04850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZH47_RS04855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZH47_RS04860	COG0019	diaminopimelate decarboxylase activity
GZH47_RS04865	COG0697	spore germination
GZH47_RS04885	COG2172	sigma factor antagonist activity
GZH47_RS04890	COG1366	Belongs to the anti-sigma-factor antagonist family
GZH47_RS04895	COG1686	Belongs to the peptidase S11 family
GZH47_RS04915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GZH47_RS04920	COG4974	Belongs to the 'phage' integrase family
GZH47_RS04930	COG0686	Belongs to the AlaDH PNT family
GZH47_RS04935	COG1404	Belongs to the peptidase S8 family
GZH47_RS04940	COG0735	belongs to the Fur family
GZH47_RS04945	COG1300	Membrane
GZH47_RS04950	COG1379	DNA repair
GZH47_RS04965	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH47_RS04975	COG0321	lipoyl(octanoyl) transferase activity
GZH47_RS04980	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZH47_RS04985	COG0022	dehydrogenase e1 component
GZH47_RS04990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZH47_RS04995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH47_RS05005	COG0740	serine-type endopeptidase activity
GZH47_RS05015	COG0477	Major facilitator Superfamily
GZH47_RS05030	COG0745	RESPONSE REGULATOR receiver
GZH47_RS05035	COG0750	zinc metalloprotease
GZH47_RS05040	COG0497	DNA recombination
GZH47_RS05045	COG1438	arginine binding
GZH47_RS05055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GZH47_RS05060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZH47_RS05070	COG1722	exodeoxyribonuclease VII activity
GZH47_RS05075	COG1570	exodeoxyribonuclease VII activity
GZH47_RS05085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZH47_RS05100	COG1302	Protein conserved in bacteria
GZH47_RS05105	COG0439	Biotin carboxylase
GZH47_RS05110	COG0511	ligase activity, forming carbon-carbon bonds
GZH47_RS05150	COG3854	ATPases associated with a variety of cellular activities
GZH47_RS05160	COG1809	phosphosulfolactate synthase activity
GZH47_RS05165	COG2045	Belongs to the ComB family
GZH47_RS05170	COG2707	UPF0756 membrane protein
GZH47_RS05180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZH47_RS05185	COG0006	proline dipeptidase activity
GZH47_RS05190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GZH47_RS05200	COG3872	metal-dependent enzyme
GZH47_RS05210	COG1321	iron dependent repressor
GZH47_RS05215	COG1533	DNA photolyase activity
GZH47_RS05220	COG0785	Cytochrome C biogenesis protein
GZH47_RS05225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZH47_RS05230	COG1121	(ABC) transporter
GZH47_RS05235	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZH47_RS05235	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZH47_RS05245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZH47_RS05270	COG4493	Belongs to the UPF0637 family
GZH47_RS05275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZH47_RS05290	COG1982	Orn Lys Arg decarboxylase major
GZH47_RS05295	COG1361	Conserved repeat domain
GZH47_RS05305	COG3906	Belongs to the UPF0473 family
GZH47_RS05320	COG1234	tRNA 3'-trailer cleavage
GZH47_RS05360	COG1376	ErfK ybiS ycfS ynhG family protein
GZH47_RS05375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZH47_RS05430	COG1136	(ABC) transporter
GZH47_RS05445	COG1136	(ABC) transporter
GZH47_RS05445	COG0577	efflux transmembrane transporter activity
GZH47_RS05460	COG1131	(ABC) transporter
GZH47_RS05480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZH47_RS05485	COG0505	Belongs to the CarA family
GZH47_RS05490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZH47_RS05495	COG0540	Belongs to the ATCase OTCase family
GZH47_RS05505	COG0436	Aminotransferase
GZH47_RS05510	COG0564	pseudouridine synthase activity
GZH47_RS05515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZH47_RS05520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GZH47_RS05535	COG3599	regulation of cell shape
GZH47_RS05540	COG2302	S4 RNA-binding domain
GZH47_RS05550	COG1799	cell septum assembly
GZH47_RS05555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZH47_RS05560	COG1496	oxidoreductase activity
GZH47_RS05565	COG1873	PFAM PRC-barrel domain
GZH47_RS05570	COG1191	sigma factor activity
GZH47_RS05585	COG1131	(ABC) transporter
GZH47_RS05600	COG2011	ABC-type metal ion transport system permease component
GZH47_RS05610	COG1191	sigma factor activity
GZH47_RS05620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GZH47_RS05625	COG0849	cell division
GZH47_RS05630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GZH47_RS05635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH47_RS05640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZH47_RS05650	COG0772	Belongs to the SEDS family
GZH47_RS05655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZH47_RS05660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH47_RS05665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZH47_RS05675	COG0768	penicillin binding
GZH47_RS05680	COG0768	penicillin binding
GZH47_RS05690	COG0275	rRNA processing
GZH47_RS05695	COG2001	Belongs to the MraZ family
GZH47_RS05710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GZH47_RS05715	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GZH47_RS05725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GZH47_RS05760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GZH47_RS05775	COG1316	TRANSCRIPTIONal
GZH47_RS05790	COG1217	gtp-binding protein TYPA
GZH47_RS05800	COG0861	Integral membrane protein TerC family
GZH47_RS05805	COG0861	Integral membrane protein TerC family
GZH47_RS05810	COG2814	Major facilitator Superfamily
GZH47_RS05820	COG0301	tRNA thio-modification
GZH47_RS05825	COG1104	cysteine desulfurase activity
GZH47_RS05830	COG0741	lytic transglycosylase activity
GZH47_RS05860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZH47_RS05865	COG2384	SAM-dependent methyltransferase
GZH47_RS05880	COG0358	DNA primase activity
GZH47_RS05885	COG1671	Belongs to the UPF0178 family
GZH47_RS05890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZH47_RS05895	COG0751	glycine-tRNA ligase activity
GZH47_RS05900	COG0752	glycyl-tRNA synthetase alpha subunit
GZH47_RS05905	COG1381	Involved in DNA repair and RecF pathway recombination
GZH47_RS05915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZH47_RS05925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZH47_RS05930	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZH47_RS05935	COG1480	7TM receptor with intracellular HD hydrolase
GZH47_RS05940	COG1702	phosphate starvation-inducible protein PhoH
GZH47_RS05960	COG4864	UPF0365 protein
GZH47_RS05965	COG1030	water channel activity
GZH47_RS05975	COG1610	YqeY-like protein
GZH47_RS05980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GZH47_RS05985	COG0537	adenosine 5'-monophosphoramidase activity
GZH47_RS06005	COG0419	ATPase involved in DNA repair
GZH47_RS06010	COG0420	3'-5' exonuclease activity
GZH47_RS06020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GZH47_RS06025	COG5566	PFAM Mor transcription activator
GZH47_RS06035	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZH47_RS06045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZH47_RS06050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZH47_RS06055	COG1994	Peptidase M50
GZH47_RS06060	COG2264	protein methyltransferase activity
GZH47_RS06080	COG0443	Heat shock 70 kDa protein
GZH47_RS06090	COG1420	regulation of RNA biosynthetic process
GZH47_RS06105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GZH47_RS06105	COG0165	Argininosuccinate lyase
GZH47_RS06110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZH47_RS06115	COG0481	GTPase activity
GZH47_RS06125	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS06130	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GZH47_RS06135	COG0268	Binds directly to 16S ribosomal RNA
GZH47_RS06145	COG1466	dna polymerase III delta subunit
GZH47_RS06155	COG1595	DNA-templated transcription, initiation
GZH47_RS06160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH47_RS06175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZH47_RS06180	COG0805	protein transport
GZH47_RS06195	COG0658	competence protein
GZH47_RS06195	COG2333	competence protein COMEC
GZH47_RS06215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZH47_RS06220	COG0495	leucyl-tRNA aminoacylation
GZH47_RS06225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZH47_RS06230	COG2996	Protein conserved in bacteria
GZH47_RS06235	COG0799	negative regulation of ribosome biogenesis
GZH47_RS06240	COG1713	HD superfamily hydrolase involved in NAD metabolism
GZH47_RS06245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GZH47_RS06250	COG1534	Rna-binding protein
GZH47_RS06255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZH47_RS06260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZH47_RS06265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GZH47_RS06280	COG0714	Associated with various cellular activities
GZH47_RS06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZH47_RS06310	COG0778	Nitroreductase
GZH47_RS06315	COG1082	Xylose isomerase domain protein TIM barrel
GZH47_RS06315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GZH47_RS06320	COG0673	inositol 2-dehydrogenase activity
GZH47_RS06345	COG0243	molybdopterin cofactor binding
GZH47_RS06350	COG0667	Aldo Keto reductase
GZH47_RS06355	COG1368	sulfuric ester hydrolase activity
GZH47_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS06370	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS06400	COG0529	Catalyzes the synthesis of activated sulfate
GZH47_RS06415	COG1609	Transcriptional regulator
GZH47_RS06435	COG1136	(ABC) transporter
GZH47_RS06440	COG0577	efflux transmembrane transporter activity
GZH47_RS06445	COG5002	protein histidine kinase activity
GZH47_RS06445	COG3850	Histidine kinase
GZH47_RS06450	COG0745	RESPONSE REGULATOR receiver
GZH47_RS06475	COG0697	spore germination
GZH47_RS06485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZH47_RS06500	COG0673	inositol 2-dehydrogenase activity
GZH47_RS06510	COG3655	Transcriptional regulator
GZH47_RS06530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GZH47_RS06570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GZH47_RS06570	COG0456	acetyltransferase
GZH47_RS06595	COG0673	inositol 2-dehydrogenase activity
GZH47_RS06600	COG2721	sulfolactate sulfo-lyase activity
GZH47_RS06605	COG2721	sulfolactate sulfo-lyase activity
GZH47_RS06625	COG0673	inositol 2-dehydrogenase activity
GZH47_RS06630	COG3481	metal-dependent phosphohydrolase, HD sub domain
GZH47_RS06645	COG0395	ABC-type sugar transport system, permease component
GZH47_RS06650	COG4209	transmembrane transport
GZH47_RS06655	COG1653	transport
GZH47_RS06660	COG4565	transcriptional regulatory protein
GZH47_RS06665	COG2972	Histidine kinase
GZH47_RS06670	COG1609	Transcriptional regulator
GZH47_RS06685	COG0673	inositol 2-dehydrogenase activity
GZH47_RS06715	COG0829	nickel cation binding
GZH47_RS06720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GZH47_RS06730	COG0804	urea catabolic process
GZH47_RS06735	COG0832	Belongs to the urease beta subunit family
GZH47_RS06740	COG0831	urea catabolic process
GZH47_RS06745	COG0129	dihydroxy-acid dehydratase activity
GZH47_RS06750	COG2801	Transposase and inactivated derivatives
GZH47_RS06770	COG0628	permease
GZH47_RS06775	COG0768	penicillin binding
GZH47_RS06780	COG0583	DNA-binding transcription factor activity
GZH47_RS06785	COG0705	Rhomboid family
GZH47_RS06790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GZH47_RS06805	COG5578	integral membrane protein
GZH47_RS06815	COG0513	Belongs to the DEAD box helicase family
GZH47_RS06820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH47_RS06835	COG0431	NADPH-dependent FMN reductase
GZH47_RS06880	COG1164	Oligoendopeptidase f
GZH47_RS06885	COG0431	NADPH-dependent FMN reductase
GZH47_RS06890	COG1136	(ABC) transporter
GZH47_RS06900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZH47_RS06905	COG0577	efflux transmembrane transporter activity
GZH47_RS06905	COG1136	(ABC) transporter
GZH47_RS06915	COG3437	response regulator, receiver
GZH47_RS06915	COG0784	Response regulator, receiver
GZH47_RS06920	COG0584	glycerophosphoryl diester phosphodiesterase
GZH47_RS06925	COG2843	Capsule synthesis protein
GZH47_RS06935	COG0697	spore germination
GZH47_RS06950	COG1304	FMN binding
GZH47_RS06955	COG0363	glucosamine-6-phosphate deaminase activity
GZH47_RS06970	COG1349	DNA-binding transcription factor activity
GZH47_RS06985	COG0514	ATP-dependent DNA helicase (RecQ)
GZH47_RS06990	COG0039	L-malate dehydrogenase activity
GZH47_RS06995	COG0538	isocitrate dehydrogenase activity
GZH47_RS07000	COG0372	Belongs to the citrate synthase family
GZH47_RS07010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZH47_RS07015	COG0628	permease
GZH47_RS07020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GZH47_RS07025	COG3030	protein affecting phage T7 exclusion by the F plasmid
GZH47_RS07040	COG0825	malonyl-CoA metabolic process
GZH47_RS07045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZH47_RS07055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZH47_RS07085	COG4109	DRTGG domain
GZH47_RS07090	COG0189	ligase activity
GZH47_RS07095	COG0189	ligase activity
GZH47_RS07100	COG0189	ligase activity
GZH47_RS07125	COG4632	Exopolysaccharide biosynthesis protein
GZH47_RS07125	COG5434	Belongs to the glycosyl hydrolase 28 family
GZH47_RS07130	COG3546	catalase activity
GZH47_RS07145	COG1253	flavin adenine dinucleotide binding
GZH47_RS07150	COG0535	radical SAM domain protein
GZH47_RS07155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GZH47_RS07155	COG2199	diguanylate cyclase activity
GZH47_RS07165	COG0737	Belongs to the 5'-nucleotidase family
GZH47_RS07175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZH47_RS07180	COG0314	molybdopterin synthase activity
GZH47_RS07190	COG0719	Fe-S assembly protein
GZH47_RS07195	COG0822	iron-sulfur transferase activity
GZH47_RS07200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZH47_RS07205	COG0719	Fe-S assembly protein
GZH47_RS07210	COG0396	ATPase activity
GZH47_RS07220	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GZH47_RS07225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GZH47_RS07230	COG3377	Domain of unknown function (DUF1805)
GZH47_RS07240	COG2363	Small membrane protein
GZH47_RS07250	COG2718	Belongs to the UPF0229 family
GZH47_RS07260	COG1368	sulfuric ester hydrolase activity
GZH47_RS07265	COG5002	protein histidine kinase activity
GZH47_RS07270	COG2719	SpoVR family
GZH47_RS07290	COG2308	Evidence 4 Homologs of previously reported genes of
GZH47_RS07300	COG2766	serine protein kinase
GZH47_RS07315	COG0436	Aminotransferase
GZH47_RS07320	COG2002	toxin-antitoxin pair type II binding
GZH47_RS07325	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GZH47_RS07330	COG0745	RESPONSE REGULATOR receiver
GZH47_RS07345	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZH47_RS07355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZH47_RS07360	COG5002	protein histidine kinase activity
GZH47_RS07360	COG3850	Histidine kinase
GZH47_RS07365	COG0745	RESPONSE REGULATOR receiver
GZH47_RS07370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH47_RS07380	COG2197	response regulator
GZH47_RS07385	COG4585	Histidine kinase
GZH47_RS07390	COG4758	membrane
GZH47_RS07395	COG0004	ammonium transporteR
GZH47_RS07410	COG1595	DNA-templated transcription, initiation
GZH47_RS07415	COG3584	3D domain protein
GZH47_RS07420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZH47_RS07430	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GZH47_RS07435	COG0626	cystathionine gamma-synthase activity
GZH47_RS07440	COG0626	cystathionine gamma-synthase activity
GZH47_RS07445	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GZH47_RS07450	COG0598	Magnesium transport protein CorA
GZH47_RS07455	COG1988	membrane-bound metal-dependent
GZH47_RS07460	COG2270	Major facilitator Superfamily
GZH47_RS07465	COG0583	DNA-binding transcription factor activity
GZH47_RS07485	COG1733	regulation of RNA biosynthetic process
GZH47_RS07490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZH47_RS07495	COG1053	succinate dehydrogenase
GZH47_RS07500	COG2009	succinate dehydrogenase
GZH47_RS07505	COG0583	DNA-binding transcription factor activity
GZH47_RS07515	COG0322	excinuclease ABC activity
GZH47_RS07545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GZH47_RS07550	COG4208	sulfate ABC transporter
GZH47_RS07555	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GZH47_RS07560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GZH47_RS07565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GZH47_RS07570	COG0737	Belongs to the 5'-nucleotidase family
GZH47_RS07580	COG1484	DNA-dependent DNA replication
GZH47_RS07600	COG3253	May function as heme-dependent peroxidase
GZH47_RS07610	COG1252	NADH dehydrogenase
GZH47_RS07625	COG0189	ligase activity
GZH47_RS07630	COG0840	transmembrane signaling receptor activity
GZH47_RS07635	COG0316	Belongs to the HesB IscA family
GZH47_RS07640	COG1272	protein, Hemolysin III
GZH47_RS07645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GZH47_RS07650	COG1252	NADH dehydrogenase
GZH47_RS07655	COG4844	belongs to the
GZH47_RS07660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GZH47_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS07675	COG1612	heme a metabolic process
GZH47_RS07680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS07690	COG2244	polysaccharide biosynthetic process
GZH47_RS07705	COG0561	phosphatase activity
GZH47_RS07710	COG0768	penicillin binding
GZH47_RS07740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS07745	COG0109	protoheme IX farnesyltransferase activity
GZH47_RS07750	COG3773	Cell wall hydrolase
GZH47_RS07765	COG1988	membrane-bound metal-dependent
GZH47_RS07780	COG0180	Tryptophanyl-tRNA synthetase
GZH47_RS07790	COG1295	ribonuclease BN
GZH47_RS07805	COG0701	Predicted permease
GZH47_RS07825	COG0840	transmembrane signaling receptor activity
GZH47_RS07835	COG3458	cephalosporin-C deacetylase activity
GZH47_RS07845	COG3583	domain protein
GZH47_RS07845	COG3584	3D domain protein
GZH47_RS07850	COG4191	Histidine kinase
GZH47_RS07855	COG1309	transcriptional regulator
GZH47_RS07860	COG2340	Cysteine-rich secretory protein family
GZH47_RS07875	COG2340	Cysteine-rich secretory protein family
GZH47_RS07905	COG0346	lactoylglutathione lyase activity
GZH47_RS07910	COG0024	Methionine aminopeptidase
GZH47_RS07915	COG0540	Belongs to the ATCase OTCase family
GZH47_RS07920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH47_RS07940	COG2207	Transcriptional regulator
GZH47_RS07945	COG3275	phosphorelay sensor kinase activity
GZH47_RS07950	COG0395	ABC-type sugar transport system, permease component
GZH47_RS07955	COG4209	transmembrane transport
GZH47_RS07960	COG1653	transport
GZH47_RS07975	COG0395	ABC-type sugar transport system, permease component
GZH47_RS07985	COG2182	Extracellular solute-binding protein
GZH47_RS07990	COG4753	response regulator
GZH47_RS07990	COG2207	Transcriptional regulator
GZH47_RS07995	COG3275	phosphorelay sensor kinase activity
GZH47_RS08060	COG2183	response to ionizing radiation
GZH47_RS08065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS08075	COG0586	Pfam SNARE associated Golgi protein
GZH47_RS08115	COG3706	GGDEF domain
GZH47_RS08140	COG4840	Belongs to the UPF0435 family
GZH47_RS08150	COG1940	carbohydrate kinase activity
GZH47_RS08160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZH47_RS08170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GZH47_RS08175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZH47_RS08180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZH47_RS08220	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GZH47_RS08250	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZH47_RS08255	COG1131	(ABC) transporter
GZH47_RS08275	COG1132	(ABC) transporter
GZH47_RS08315	COG1316	TRANSCRIPTIONal
GZH47_RS08330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZH47_RS08335	COG2244	polysaccharide biosynthetic process
GZH47_RS08360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GZH47_RS08370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH47_RS08375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZH47_RS08380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH47_RS08385	COG0489	protein tyrosine kinase activity
GZH47_RS08390	COG3944	biosynthesis protein
GZH47_RS08395	COG4464	protein tyrosine phosphatase activity
GZH47_RS08400	COG1396	sequence-specific DNA binding
GZH47_RS08410	COG0070	glutamate synthase
GZH47_RS08410	COG0069	glutamate synthase activity
GZH47_RS08410	COG0067	glutamate synthase
GZH47_RS08420	COG1511	domain protein
GZH47_RS08425	COG1309	transcriptional regulator
GZH47_RS08435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZH47_RS08460	COG0488	(ABC) transporter
GZH47_RS08470	COG1413	lyase activity
GZH47_RS08480	COG2207	Transcriptional regulator
GZH47_RS08480	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS08490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS08495	COG0456	acetyltransferase
GZH47_RS08500	COG1473	amidohydrolase
GZH47_RS08515	COG1063	alcohol dehydrogenase
GZH47_RS08530	COG0667	Aldo Keto reductase
GZH47_RS08550	COG3292	Two component regulator propeller
GZH47_RS08550	COG2205	protein histidine kinase activity
GZH47_RS08550	COG0745	RESPONSE REGULATOR receiver
GZH47_RS08555	COG4209	transmembrane transport
GZH47_RS08560	COG0395	ABC-type sugar transport system, permease component
GZH47_RS08580	COG1090	epimerase
GZH47_RS08640	COG2207	Transcriptional regulator
GZH47_RS08640	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS08645	COG1653	transport
GZH47_RS08650	COG0395	ABC-type sugar transport system, permease component
GZH47_RS08655	COG4209	transmembrane transport
GZH47_RS08665	COG2207	Transcriptional regulator
GZH47_RS08675	COG5285	phytanoyl-CoA dioxygenase
GZH47_RS08690	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GZH47_RS08705	COG1312	Catalyzes the dehydration of D-mannonate
GZH47_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS08720	COG0154	amidase activity
GZH47_RS08725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZH47_RS08730	COG0789	Transcriptional regulator
GZH47_RS08765	COG1132	(ABC) transporter
GZH47_RS08770	COG1132	(ABC) transporter
GZH47_RS08790	COG0667	Aldo Keto reductase
GZH47_RS08800	COG2972	Histidine kinase
GZH47_RS08805	COG0395	ABC-type sugar transport system, permease component
GZH47_RS08810	COG4209	transmembrane transport
GZH47_RS08815	COG1653	transport
GZH47_RS08825	COG0673	inositol 2-dehydrogenase activity
GZH47_RS08845	COG2814	Major facilitator Superfamily
GZH47_RS08870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH47_RS08875	COG0156	8-amino-7-oxononanoate synthase activity
GZH47_RS08880	COG1396	sequence-specific DNA binding
GZH47_RS08890	COG1609	Transcriptional regulator
GZH47_RS08900	COG0395	ABC-type sugar transport system, permease component
GZH47_RS08905	COG4209	transmembrane transport
GZH47_RS08915	COG3275	phosphorelay sensor kinase activity
GZH47_RS08920	COG0395	ABC-type sugar transport system, permease component
GZH47_RS08925	COG1175	transmembrane transport
GZH47_RS08930	COG1653	transport
GZH47_RS08970	COG4282	regulation of fungal-type cell wall biogenesis
GZH47_RS09000	COG0800	Aldolase
GZH47_RS09015	COG2010	Cytochrome c
GZH47_RS09025	COG0736	holo-[acyl-carrier-protein] synthase activity
GZH47_RS09055	COG3852	Histidine kinase
GZH47_RS09060	COG2081	HI0933 family
GZH47_RS09075	COG1070	Carbohydrate kinase
GZH47_RS09080	COG2115	Belongs to the xylose isomerase family
GZH47_RS09085	COG1940	carbohydrate kinase activity
GZH47_RS09095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH47_RS09105	COG2207	Transcriptional regulator
GZH47_RS09105	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS09130	COG1595	DNA-templated transcription, initiation
GZH47_RS09135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GZH47_RS09140	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GZH47_RS09145	COG1733	regulation of RNA biosynthetic process
GZH47_RS09150	COG1486	melibiose metabolic process
GZH47_RS09155	COG2207	Transcriptional regulator
GZH47_RS09170	COG2814	Major facilitator Superfamily
GZH47_RS09205	COG1215	transferase activity, transferring glycosyl groups
GZH47_RS09235	COG0778	Nitroreductase
GZH47_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS09295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS09365	COG2223	nitrite transmembrane transporter activity
GZH47_RS09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZH47_RS09380	COG1136	(ABC) transporter
GZH47_RS09380	COG0577	efflux transmembrane transporter activity
GZH47_RS09385	COG1136	(ABC) transporter
GZH47_RS09405	COG1595	DNA-templated transcription, initiation
GZH47_RS09415	COG4977	sequence-specific DNA binding
GZH47_RS09415	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS09420	COG3706	GGDEF domain
GZH47_RS09425	COG2207	Transcriptional regulator
GZH47_RS09425	COG4753	response regulator
GZH47_RS09430	COG0395	ABC-type sugar transport system, permease component
GZH47_RS09435	COG1175	transmembrane transport
GZH47_RS09475	COG2972	Histidine kinase
GZH47_RS09480	COG1595	DNA-templated transcription, initiation
GZH47_RS09485	COG4952	isomerase
GZH47_RS09490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZH47_RS09500	COG1063	alcohol dehydrogenase
GZH47_RS09515	COG1609	Transcriptional regulator
GZH47_RS09520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZH47_RS09535	COG4989	oxidoreductase activity
GZH47_RS09545	COG1609	Transcriptional regulator
GZH47_RS09550	COG0383	alpha-mannosidase activity
GZH47_RS09560	COG1309	transcriptional regulator
GZH47_RS09570	COG1131	(ABC) transporter
GZH47_RS09580	COG1595	DNA-templated transcription, initiation
GZH47_RS09595	COG2271	Major facilitator Superfamily
GZH47_RS09605	COG1227	inorganic diphosphatase activity
GZH47_RS09615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS09635	COG0095	Lipoate-protein ligase
GZH47_RS09645	COG2814	Major facilitator Superfamily
GZH47_RS09665	COG1175	transmembrane transport
GZH47_RS09670	COG2972	Histidine kinase
GZH47_RS09675	COG2207	Transcriptional regulator
GZH47_RS09675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS09680	COG1696	Membrane protein involved in D-alanine export
GZH47_RS09700	COG4753	response regulator
GZH47_RS09700	COG2207	Transcriptional regulator
GZH47_RS09705	COG3275	phosphorelay sensor kinase activity
GZH47_RS09730	COG1874	Beta-galactosidase
GZH47_RS09740	COG3833	ABC-type maltose transport systems, permease component
GZH47_RS09745	COG1175	transmembrane transport
GZH47_RS09765	COG0395	ABC-type sugar transport system, permease component
GZH47_RS09785	COG0768	penicillin binding
GZH47_RS09790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH47_RS09800	COG2271	Major facilitator Superfamily
GZH47_RS09805	COG0697	spore germination
GZH47_RS09815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZH47_RS09830	COG5002	protein histidine kinase activity
GZH47_RS09835	COG0745	RESPONSE REGULATOR receiver
GZH47_RS09850	COG0697	spore germination
GZH47_RS09865	COG2323	membrane
GZH47_RS09870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZH47_RS09880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZH47_RS09895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS09920	COG1653	transport
GZH47_RS09925	COG0395	ABC-type sugar transport system, permease component
GZH47_RS09930	COG4209	transmembrane transport
GZH47_RS09970	COG0395	ABC-type sugar transport system, permease component
GZH47_RS09975	COG4209	transmembrane transport
GZH47_RS09980	COG1609	Transcriptional regulator
GZH47_RS09985	COG0584	glycerophosphoryl diester phosphodiesterase
GZH47_RS10010	COG3842	ATPase activity
GZH47_RS10015	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10020	COG1609	Transcriptional regulator
GZH47_RS10025	COG3344	reverse transcriptase
GZH47_RS10030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZH47_RS10035	COG0697	spore germination
GZH47_RS10050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GZH47_RS10055	COG3483	tryptophan 2,3-dioxygenase activity
GZH47_RS10070	COG2207	Transcriptional regulator
GZH47_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS10090	COG3250	beta-galactosidase activity
GZH47_RS10100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZH47_RS10100	COG2755	lipolytic protein G-D-S-L family
GZH47_RS10105	COG1349	DNA-binding transcription factor activity
GZH47_RS10120	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS10125	COG0444	Belongs to the ABC transporter superfamily
GZH47_RS10130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS10135	COG0601	transmembrane transport
GZH47_RS10140	COG0747	negative chemotaxis
GZH47_RS10145	COG2207	Transcriptional regulator
GZH47_RS10145	COG0662	Cupin 2, conserved barrel domain protein
GZH47_RS10150	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10165	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10185	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10190	COG1175	transmembrane transport
GZH47_RS10200	COG3842	ATPase activity
GZH47_RS10230	COG1668	transmembrane transport
GZH47_RS10235	COG4152	abc transporter atp-binding protein
GZH47_RS10240	COG1131	(ABC) transporter
GZH47_RS10255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GZH47_RS10260	COG3397	chitin binding
GZH47_RS10270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZH47_RS10290	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS10295	COG1802	Transcriptional regulator
GZH47_RS10300	COG1312	Catalyzes the dehydration of D-mannonate
GZH47_RS10305	COG1653	transport
GZH47_RS10310	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10315	COG1175	transmembrane transport
GZH47_RS10325	COG2207	Transcriptional regulator
GZH47_RS10380	COG2801	Transposase and inactivated derivatives
GZH47_RS10395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS10405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS10410	COG0247	lactate metabolic process
GZH47_RS10415	COG0277	FAD linked oxidase domain protein
GZH47_RS10420	COG2186	Transcriptional regulator
GZH47_RS10440	COG0673	inositol 2-dehydrogenase activity
GZH47_RS10450	COG1349	DNA-binding transcription factor activity
GZH47_RS10465	COG3336	cytochrome c oxidase
GZH47_RS10485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZH47_RS10485	COG2010	Cytochrome c
GZH47_RS10495	COG1846	Transcriptional regulator
GZH47_RS10500	COG2259	Doxx family
GZH47_RS10510	COG1486	melibiose metabolic process
GZH47_RS10515	COG2207	Transcriptional regulator
GZH47_RS10540	COG2207	Transcriptional regulator
GZH47_RS10560	COG1131	(ABC) transporter
GZH47_RS10580	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10585	COG4209	transmembrane transport
GZH47_RS10595	COG1609	Transcriptional regulator
GZH47_RS10610	COG2207	Transcriptional regulator
GZH47_RS10610	COG3708	Transcriptional regulator
GZH47_RS10615	COG1366	Belongs to the anti-sigma-factor antagonist family
GZH47_RS10625	COG1191	sigma factor activity
GZH47_RS10630	COG0598	Magnesium transport protein CorA
GZH47_RS10635	COG2208	phosphoserine phosphatase activity
GZH47_RS10645	COG2315	Protein conserved in bacteria
GZH47_RS10670	COG1876	peptidase activity
GZH47_RS10680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH47_RS10685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS10690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GZH47_RS10730	COG1285	pathogenesis
GZH47_RS10740	COG0531	amino acid
GZH47_RS10755	COG0242	peptide deformylase activity
GZH47_RS10780	COG0673	inositol 2-dehydrogenase activity
GZH47_RS10785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZH47_RS10785	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZH47_RS10795	COG0395	ABC-type sugar transport system, permease component
GZH47_RS10800	COG1175	transmembrane transport
GZH47_RS10825	COG0667	Aldo Keto reductase
GZH47_RS10835	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS10850	COG0673	inositol 2-dehydrogenase activity
GZH47_RS10855	COG2079	MmgE PrpD family protein
GZH47_RS10860	COG0372	Belongs to the citrate synthase family
GZH47_RS10865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GZH47_RS10870	COG1960	acyl-CoA dehydrogenase activity
GZH47_RS10875	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZH47_RS10880	COG0183	Belongs to the thiolase family
GZH47_RS10885	COG1960	acyl-CoA dehydrogenase activity
GZH47_RS10895	COG0463	Glycosyl transferase, family 2
GZH47_RS10910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GZH47_RS10920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GZH47_RS10925	COG2390	Transcriptional regulator
GZH47_RS10930	COG1079	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS10935	COG4603	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS10940	COG3845	ABC transporter
GZH47_RS10945	COG1744	ABC transporter substrate-binding protein PnrA-like
GZH47_RS10950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GZH47_RS10950	COG2755	lipolytic protein G-D-S-L family
GZH47_RS10955	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS10960	COG2226	methyltransferase
GZH47_RS10975	COG3386	PFAM SMP-30 Gluconolaconase
GZH47_RS10980	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS11085	COG0693	protein deglycase activity
GZH47_RS11095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZH47_RS11100	COG1335	isochorismatase
GZH47_RS11105	COG1051	belongs to the nudix hydrolase family
GZH47_RS11105	COG1056	cytidyltransferase-related domain
GZH47_RS11175	COG0488	(ABC) transporter
GZH47_RS11180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZH47_RS11185	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS11205	COG0395	ABC-type sugar transport system, permease component
GZH47_RS11210	COG1175	transmembrane transport
GZH47_RS11215	COG2182	Extracellular solute-binding protein
GZH47_RS11230	COG2972	Histidine kinase
GZH47_RS11235	COG2207	Transcriptional regulator
GZH47_RS11240	COG0745	RESPONSE REGULATOR receiver
GZH47_RS11250	COG2205	protein histidine kinase activity
GZH47_RS11255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GZH47_RS11260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GZH47_RS11315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GZH47_RS11320	COG4999	Histidine kinase
GZH47_RS11320	COG3850	Histidine kinase
GZH47_RS11320	COG3437	response regulator, receiver
GZH47_RS11320	COG2205	protein histidine kinase activity
GZH47_RS11335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZH47_RS11350	COG0673	inositol 2-dehydrogenase activity
GZH47_RS11360	COG0395	ABC-type sugar transport system, permease component
GZH47_RS11365	COG4209	transmembrane transport
GZH47_RS11375	COG3266	domain, Protein
GZH47_RS11375	COG2911	Protein conserved in bacteria
GZH47_RS11375	COG1361	Conserved repeat domain
GZH47_RS11380	COG0673	inositol 2-dehydrogenase activity
GZH47_RS11385	COG2207	Transcriptional regulator
GZH47_RS11390	COG3275	phosphorelay sensor kinase activity
GZH47_RS11400	COG0840	transmembrane signaling receptor activity
GZH47_RS11410	COG0395	ABC-type sugar transport system, permease component
GZH47_RS11415	COG1175	transmembrane transport
GZH47_RS11420	COG1653	transport
GZH47_RS11430	COG0405	Gamma-glutamyltransferase
GZH47_RS11445	COG0463	Glycosyl transferase, family 2
GZH47_RS11450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH47_RS11455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZH47_RS11460	COG1846	Transcriptional regulator
GZH47_RS11470	COG0667	Aldo Keto reductase
GZH47_RS11475	COG0028	Belongs to the TPP enzyme family
GZH47_RS11480	COG1960	acyl-CoA dehydrogenase activity
GZH47_RS11485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZH47_RS11495	COG3708	Transcriptional regulator
GZH47_RS11495	COG2207	Transcriptional regulator
GZH47_RS11505	COG1486	melibiose metabolic process
GZH47_RS11535	COG1388	LysM domain
GZH47_RS11540	COG1064	alcohol dehydrogenase
GZH47_RS11545	COG1132	(ABC) transporter
GZH47_RS11550	COG1132	(ABC) transporter
GZH47_RS11560	COG1846	Transcriptional regulator
GZH47_RS11575	COG0673	inositol 2-dehydrogenase activity
GZH47_RS11580	COG0673	inositol 2-dehydrogenase activity
GZH47_RS11590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZH47_RS11600	COG0673	inositol 2-dehydrogenase activity
GZH47_RS11610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS11610	COG2207	Transcriptional regulator
GZH47_RS11630	COG0395	ABC-type sugar transport system, permease component
GZH47_RS11635	COG4209	transmembrane transport
GZH47_RS11650	COG1289	transmembrane transporter activity
GZH47_RS11655	COG0598	Magnesium transport protein CorA
GZH47_RS11690	COG2076	Multidrug Resistance protein
GZH47_RS11705	COG2814	Major facilitator Superfamily
GZH47_RS11710	COG2207	Transcriptional regulator
GZH47_RS11715	COG2972	Histidine kinase
GZH47_RS11755	COG1653	transport
GZH47_RS11760	COG0395	ABC-type sugar transport system, permease component
GZH47_RS11765	COG4209	transmembrane transport
GZH47_RS11785	COG2972	Histidine kinase
GZH47_RS11790	COG0457	Tetratricopeptide repeat
GZH47_RS11860	COG1192	Involved in chromosome partitioning
GZH47_RS11870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GZH47_RS11875	COG1597	lipid kinase activity
GZH47_RS11885	COG4496	protein, YerC YecD
GZH47_RS11895	COG0306	phosphate transporter
GZH47_RS11900	COG1392	Phosphate transport regulator
GZH47_RS11905	COG1470	cell adhesion involved in biofilm formation
GZH47_RS11915	COG1595	DNA-templated transcription, initiation
GZH47_RS11920	COG5002	protein histidine kinase activity
GZH47_RS11925	COG0745	RESPONSE REGULATOR receiver
GZH47_RS11945	COG0151	Belongs to the GarS family
GZH47_RS11955	COG0138	bifunctional purine biosynthesis protein purh
GZH47_RS11960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZH47_RS11965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZH47_RS11970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZH47_RS11975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZH47_RS11980	COG0047	phosphoribosylformylglycinamidine synthase activity
GZH47_RS11985	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZH47_RS11995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZH47_RS12000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZH47_RS12005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZH47_RS12010	COG1131	(ABC) transporter
GZH47_RS12025	COG2252	PERMEase
GZH47_RS12030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZH47_RS12040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZH47_RS12040	COG0519	Catalyzes the synthesis of GMP from XMP
GZH47_RS12050	COG0739	heme binding
GZH47_RS12060	COG1305	Transglutaminase-like
GZH47_RS12070	COG0714	Associated with various cellular activities
GZH47_RS12075	COG0793	Belongs to the peptidase S41A family
GZH47_RS12085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZH47_RS12160	COG4294	response to UV
GZH47_RS12180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZH47_RS12205	COG1414	Transcriptional regulator
GZH47_RS12215	COG0302	gtp cyclohydrolase
GZH47_RS12230	COG0681	Belongs to the peptidase S26 family
GZH47_RS12255	COG1091	dTDP-4-dehydrorhamnose reductase activity
GZH47_RS12270	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GZH47_RS12320	COG1682	transport, permease protein
GZH47_RS12330	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS12335	COG1091	dTDP-4-dehydrorhamnose reductase activity
GZH47_RS12350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZH47_RS12365	COG1069	ribulokinase activity
GZH47_RS12375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH47_RS12390	COG0783	Belongs to the Dps family
GZH47_RS12395	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS12395	COG2207	Transcriptional regulator
GZH47_RS12400	COG0534	Mate efflux family protein
GZH47_RS12410	COG0488	(ABC) transporter
GZH47_RS12440	COG0024	Methionine aminopeptidase
GZH47_RS12460	COG0318	PFAM AMP-dependent synthetase and ligase
GZH47_RS12465	COG1960	acyl-CoA dehydrogenase activity
GZH47_RS12470	COG0183	Belongs to the thiolase family
GZH47_RS12475	COG1250	3-hydroxyacyl-CoA dehydrogenase
GZH47_RS12475	COG1024	Enoyl-CoA hydratase
GZH47_RS12480	COG0247	lactate metabolic process
GZH47_RS12480	COG2181	nitrate reductase activity
GZH47_RS12490	COG2086	electron transfer activity
GZH47_RS12520	COG2326	polyphosphate kinase activity
GZH47_RS12525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GZH47_RS12535	COG2814	Major facilitator Superfamily
GZH47_RS12540	COG0398	Pfam SNARE associated Golgi protein
GZH47_RS12555	COG1595	DNA-templated transcription, initiation
GZH47_RS12565	COG4129	membrane
GZH47_RS12575	COG4191	Histidine kinase
GZH47_RS12580	COG1970	mechanosensitive ion channel activity
GZH47_RS12585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GZH47_RS12605	COG0784	Response regulator, receiver
GZH47_RS12605	COG2205	protein histidine kinase activity
GZH47_RS12615	COG0745	RESPONSE REGULATOR receiver
GZH47_RS12620	COG0784	Response regulator, receiver
GZH47_RS12620	COG2205	protein histidine kinase activity
GZH47_RS12620	COG5002	protein histidine kinase activity
GZH47_RS12635	COG2770	Histidine kinase
GZH47_RS12635	COG3437	response regulator, receiver
GZH47_RS12640	COG2132	Multicopper oxidase
GZH47_RS12680	COG1653	transport
GZH47_RS12685	COG3833	ABC-type maltose transport systems, permease component
GZH47_RS12690	COG1175	transmembrane transport
GZH47_RS12700	COG2972	Histidine kinase
GZH47_RS12705	COG4753	response regulator
GZH47_RS12705	COG2207	Transcriptional regulator
GZH47_RS12710	COG2264	protein methyltransferase activity
GZH47_RS12720	COG3534	alpha-L-arabinofuranosidase
GZH47_RS12730	COG5002	protein histidine kinase activity
GZH47_RS12735	COG0745	RESPONSE REGULATOR receiver
GZH47_RS12745	COG0598	Magnesium transport protein CorA
GZH47_RS12760	COG2197	response regulator
GZH47_RS12765	COG4585	Histidine kinase
GZH47_RS12770	COG0842	Transport permease protein
GZH47_RS12775	COG1131	(ABC) transporter
GZH47_RS12805	COG0243	molybdopterin cofactor binding
GZH47_RS12810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GZH47_RS12825	COG4753	response regulator
GZH47_RS12825	COG2207	Transcriptional regulator
GZH47_RS12830	COG2972	Histidine kinase
GZH47_RS12835	COG0395	ABC-type sugar transport system, permease component
GZH47_RS12840	COG4209	transmembrane transport
GZH47_RS12845	COG1653	transport
GZH47_RS12850	COG0386	Belongs to the glutathione peroxidase family
GZH47_RS12895	COG0673	inositol 2-dehydrogenase activity
GZH47_RS12910	COG0194	GDP metabolic process
GZH47_RS12920	COG1388	LysM domain
GZH47_RS12920	COG3858	chitin binding
GZH47_RS12930	COG1842	Phage shock protein A
GZH47_RS12960	COG0626	cystathionine gamma-synthase activity
GZH47_RS12965	COG0395	ABC-type sugar transport system, permease component
GZH47_RS12970	COG1175	transmembrane transport
GZH47_RS12980	COG2188	Transcriptional regulator
GZH47_RS12985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZH47_RS12990	COG1361	Conserved repeat domain
GZH47_RS12990	COG2911	Protein conserved in bacteria
GZH47_RS12990	COG3266	domain, Protein
GZH47_RS13030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZH47_RS13040	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS13045	COG0444	Belongs to the ABC transporter superfamily
GZH47_RS13050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS13055	COG0601	transmembrane transport
GZH47_RS13075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH47_RS13080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS13085	COG0662	Cupin 2, conserved barrel domain protein
GZH47_RS13100	COG1132	(ABC) transporter
GZH47_RS13105	COG1132	(ABC) transporter
GZH47_RS13120	COG2309	aminopeptidase activity
GZH47_RS13130	COG0765	amino acid transport
GZH47_RS13145	COG2733	membrane
GZH47_RS13150	COG4753	response regulator
GZH47_RS13150	COG2207	Transcriptional regulator
GZH47_RS13155	COG2972	Histidine kinase
GZH47_RS13165	COG1175	transmembrane transport
GZH47_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS13205	COG1741	Belongs to the pirin family
GZH47_RS13240	COG3275	phosphorelay sensor kinase activity
GZH47_RS13245	COG2207	Transcriptional regulator
GZH47_RS13245	COG4753	response regulator
GZH47_RS13250	COG4209	transmembrane transport
GZH47_RS13255	COG0395	ABC-type sugar transport system, permease component
GZH47_RS13260	COG1653	transport
GZH47_RS13285	COG2207	Transcriptional regulator
GZH47_RS13285	COG3708	Transcriptional regulator
GZH47_RS13305	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS13350	COG1051	belongs to the nudix hydrolase family
GZH47_RS13360	COG1309	transcriptional regulator
GZH47_RS13370	COG1595	DNA-templated transcription, initiation
GZH47_RS13390	COG5001	Diguanylate cyclase
GZH47_RS13395	COG0406	alpha-ribazole phosphatase activity
GZH47_RS13410	COG4585	Histidine kinase
GZH47_RS13415	COG2197	response regulator
GZH47_RS13440	COG0494	nUDIX hydrolase
GZH47_RS13460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZH47_RS13475	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS13485	COG1053	succinate dehydrogenase
GZH47_RS13525	COG0840	transmembrane signaling receptor activity
GZH47_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS13570	COG0561	phosphatase activity
GZH47_RS13580	COG1940	carbohydrate kinase activity
GZH47_RS13590	COG0501	Belongs to the peptidase M48B family
GZH47_RS13610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS13625	COG0328	RNA-DNA hybrid ribonuclease activity
GZH47_RS13625	COG3341	Caulimovirus viroplasmin
GZH47_RS13645	COG1247	-acetyltransferase
GZH47_RS13650	COG0726	polysaccharide deacetylase
GZH47_RS13685	COG1051	belongs to the nudix hydrolase family
GZH47_RS13690	COG2040	homocysteine
GZH47_RS13695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZH47_RS13700	COG1126	abc transporter atp-binding protein
GZH47_RS13705	COG0765	amino acid transport
GZH47_RS13710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH47_RS13725	COG1609	Transcriptional regulator
GZH47_RS13735	COG0395	ABC-type sugar transport system, permease component
GZH47_RS13740	COG4209	transmembrane transport
GZH47_RS13745	COG1653	transport
GZH47_RS13770	COG5566	PFAM Mor transcription activator
GZH47_RS13785	COG1607	acyl-coa hydrolase
GZH47_RS13805	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS13805	COG4977	sequence-specific DNA binding
GZH47_RS13815	COG1285	pathogenesis
GZH47_RS13835	COG1595	DNA-templated transcription, initiation
GZH47_RS13845	COG0326	Molecular chaperone. Has ATPase activity
GZH47_RS13850	COG0572	uridine kinase
GZH47_RS13875	COG0726	polysaccharide deacetylase
GZH47_RS13875	COG1649	PFAM Uncharacterised BCR, COG1649
GZH47_RS13890	COG0726	polysaccharide deacetylase
GZH47_RS13900	COG1082	Xylose isomerase domain protein TIM barrel
GZH47_RS13905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZH47_RS13940	COG1252	NADH dehydrogenase
GZH47_RS13950	COG0519	Catalyzes the synthesis of GMP from XMP
GZH47_RS13950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZH47_RS13965	COG4989	oxidoreductase activity
GZH47_RS13975	COG0534	Mate efflux family protein
GZH47_RS13980	COG0653	protein targeting
GZH47_RS13985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH47_RS14000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZH47_RS14015	COG3541	Predicted nucleotidyltransferase
GZH47_RS14075	COG1361	Conserved repeat domain
GZH47_RS14085	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14090	COG4209	transmembrane transport
GZH47_RS14110	COG2207	Transcriptional regulator
GZH47_RS14140	COG1132	(ABC) transporter
GZH47_RS14160	COG3842	ATPase activity
GZH47_RS14165	COG1178	ABC-type Fe3 transport system permease component
GZH47_RS14185	COG1230	cation diffusion facilitator family transporter
GZH47_RS14195	COG0383	alpha-mannosidase activity
GZH47_RS14210	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14220	COG1653	transport
GZH47_RS14225	COG4753	response regulator
GZH47_RS14225	COG2207	Transcriptional regulator
GZH47_RS14230	COG2972	Histidine kinase
GZH47_RS14235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZH47_RS14240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZH47_RS14265	COG3250	beta-galactosidase activity
GZH47_RS14270	COG3250	beta-galactosidase activity
GZH47_RS14275	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14280	COG4209	transmembrane transport
GZH47_RS14290	COG3940	Belongs to the glycosyl hydrolase 43 family
GZH47_RS14295	COG3940	Belongs to the glycosyl hydrolase 43 family
GZH47_RS14305	COG4260	virion core protein, lumpy skin disease virus
GZH47_RS14310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GZH47_RS14315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZH47_RS14320	COG1842	Phage shock protein A
GZH47_RS14325	COG0673	inositol 2-dehydrogenase activity
GZH47_RS14330	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14335	COG4209	transmembrane transport
GZH47_RS14340	COG1653	transport
GZH47_RS14345	COG2207	Transcriptional regulator
GZH47_RS14345	COG4753	response regulator
GZH47_RS14350	COG3275	phosphorelay sensor kinase activity
GZH47_RS14355	COG1653	transport
GZH47_RS14360	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14365	COG4209	transmembrane transport
GZH47_RS14515	COG0653	protein targeting
GZH47_RS14520	COG2188	Transcriptional regulator
GZH47_RS14525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZH47_RS14540	COG3964	amidohydrolase
GZH47_RS14550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH47_RS14570	COG3290	protein histidine kinase activity
GZH47_RS14570	COG0840	transmembrane signaling receptor activity
GZH47_RS14590	COG0395	ABC-type sugar transport system, permease component
GZH47_RS14595	COG1175	transmembrane transport
GZH47_RS14630	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS14660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZH47_RS14665	COG0557	exoribonuclease II activity
GZH47_RS14670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZH47_RS14695	COG0148	phosphopyruvate hydratase activity
GZH47_RS14700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZH47_RS14705	COG0149	triose-phosphate isomerase activity
GZH47_RS14710	COG0126	phosphoglycerate kinase activity
GZH47_RS14730	COG0740	serine-type endopeptidase activity
GZH47_RS14740	COG2968	Membrane
GZH47_RS14745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH47_RS14750	COG1481	regulation of sporulation
GZH47_RS14755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZH47_RS14760	COG1660	Displays ATPase and GTPase activities
GZH47_RS14765	COG1940	carbohydrate kinase activity
GZH47_RS14775	COG0457	Tetratricopeptide repeat
GZH47_RS14785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GZH47_RS14785	COG0140	phosphoribosyl-ATP diphosphatase activity
GZH47_RS14790	COG0107	imidazoleglycerol-phosphate synthase activity
GZH47_RS14795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GZH47_RS14800	COG0131	Imidazoleglycerol-phosphate dehydratase
GZH47_RS14805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZH47_RS14810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZH47_RS14815	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GZH47_RS14820	COG0726	polysaccharide deacetylase
GZH47_RS14820	COG1649	PFAM Uncharacterised BCR, COG1649
GZH47_RS14825	COG0110	maltose O-acetyltransferase activity
GZH47_RS14830	COG0546	phosphoglycolate phosphatase activity
GZH47_RS14840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GZH47_RS14845	COG3842	ATPase activity
GZH47_RS14850	COG2508	Transcriptional regulator
GZH47_RS14855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH47_RS14915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZH47_RS14920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZH47_RS14925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZH47_RS14940	COG0254	rRNA binding
GZH47_RS14950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GZH47_RS14955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH47_RS14960	COG2204	response regulator
GZH47_RS14965	COG0504	CTP synthase activity
GZH47_RS14970	COG3343	RNA polymerase activity
GZH47_RS14975	COG1404	Belongs to the peptidase S8 family
GZH47_RS14980	COG0018	arginyl-trna synthetase
GZH47_RS15005	COG0395	ABC-type sugar transport system, permease component
GZH47_RS15010	COG1175	transmembrane transport
GZH47_RS15015	COG1653	transport
GZH47_RS15020	COG1609	Transcriptional regulator
GZH47_RS15030	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GZH47_RS15035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH47_RS15050	COG1132	(ABC) transporter
GZH47_RS15055	COG1132	(ABC) transporter
GZH47_RS15060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS15060	COG2207	Transcriptional regulator
GZH47_RS15070	COG1819	glycosyl
GZH47_RS15075	COG0791	NLP P60 protein
GZH47_RS15085	COG1595	DNA-templated transcription, initiation
GZH47_RS15095	COG0716	FMN binding
GZH47_RS15115	COG0791	NLP P60 protein
GZH47_RS15125	COG1201	RNA secondary structure unwinding
GZH47_RS15135	COG3458	cephalosporin-C deacetylase activity
GZH47_RS15175	COG0708	Exodeoxyribonuclease III
GZH47_RS15180	COG1418	mRNA catabolic process
GZH47_RS15250	COG1846	Transcriptional regulator
GZH47_RS15255	COG2814	Major facilitator Superfamily
GZH47_RS15260	COG0655	NAD(P)H dehydrogenase (quinone) activity
GZH47_RS15275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GZH47_RS15280	COG0583	DNA-binding transcription factor activity
GZH47_RS15300	COG0583	DNA-binding transcription factor activity
GZH47_RS15305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH47_RS15315	COG2814	Major facilitator Superfamily
GZH47_RS15330	COG1309	transcriptional regulator
GZH47_RS15335	COG0477	Major facilitator Superfamily
GZH47_RS15370	COG1595	DNA-templated transcription, initiation
GZH47_RS15385	COG0667	Aldo Keto reductase
GZH47_RS15395	COG0667	Aldo Keto reductase
GZH47_RS15405	COG1113	amino acid transport
GZH47_RS15410	COG1472	Belongs to the glycosyl hydrolase 3 family
GZH47_RS15420	COG1361	Conserved repeat domain
GZH47_RS15450	COG2124	cytochrome p450
GZH47_RS15455	COG4464	protein tyrosine phosphatase activity
GZH47_RS15470	COG0596	Alpha beta hydrolase
GZH47_RS15475	COG0667	Aldo Keto reductase
GZH47_RS15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS15495	COG0579	oxidoreductase
GZH47_RS15500	COG0488	(ABC) transporter
GZH47_RS15505	COG4124	Belongs to the glycosyl hydrolase 26 family
GZH47_RS15545	COG0189	ligase activity
GZH47_RS15555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GZH47_RS15595	COG2814	Major facilitator Superfamily
GZH47_RS15600	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS15620	COG2155	Conserved Protein
GZH47_RS15625	COG2154	pterin-4-alpha-carbinolamine dehydratase
GZH47_RS15635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GZH47_RS15640	COG1360	Flagellar Motor Protein
GZH47_RS15650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GZH47_RS15655	COG1187	pseudouridine synthase activity
GZH47_RS15665	COG5002	protein histidine kinase activity
GZH47_RS15670	COG0590	tRNA wobble adenosine to inosine editing
GZH47_RS15685	COG0840	transmembrane signaling receptor activity
GZH47_RS15710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZH47_RS15725	COG1686	Belongs to the peptidase S11 family
GZH47_RS15730	COG0516	GMP reductase activity
GZH47_RS15730	COG0517	IMP dehydrogenase activity
GZH47_RS15765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GZH47_RS15770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZH47_RS15775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZH47_RS15780	COG1396	sequence-specific DNA binding
GZH47_RS15785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZH47_RS15790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GZH47_RS15795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZH47_RS15800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZH47_RS15805	COG0512	Glutamine amidotransferase of anthranilate synthase
GZH47_RS15810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZH47_RS15815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZH47_RS15820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZH47_RS15830	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GZH47_RS15835	COG0157	Belongs to the NadC ModD family
GZH47_RS15840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GZH47_RS15845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GZH47_RS15850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH47_RS15860	COG0037	tRNA processing
GZH47_RS15870	COG2304	oxidoreductase activity
GZH47_RS15880	COG2208	phosphoserine phosphatase activity
GZH47_RS15885	COG1098	S1 RNA binding domain
GZH47_RS15905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZH47_RS15910	COG0776	regulation of translation
GZH47_RS15915	COG3956	TIGRFAM MazG family protein
GZH47_RS15920	COG2244	polysaccharide biosynthetic process
GZH47_RS15925	COG2002	toxin-antitoxin pair type II binding
GZH47_RS15930	COG1116	anion transmembrane transporter activity
GZH47_RS15935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS15940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS15960	COG0559	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS15975	COG2706	6-phosphogluconolactonase activity
GZH47_RS15985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZH47_RS16005	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZH47_RS16010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GZH47_RS16015	COG2088	sporulation resulting in formation of a cellular spore
GZH47_RS16020	COG0251	oxidation-reduction process
GZH47_RS16025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH47_RS16030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GZH47_RS16040	COG4466	Protein conserved in bacteria
GZH47_RS16050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZH47_RS16060	COG3583	domain protein
GZH47_RS16060	COG3584	3D domain protein
GZH47_RS16065	COG0084	hydrolase, TatD family'
GZH47_RS16070	COG1078	dGTPase activity
GZH47_RS16075	COG2002	toxin-antitoxin pair type II binding
GZH47_RS16080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZH47_RS16085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZH47_RS16090	COG4467	Involved in initiation control of chromosome replication
GZH47_RS16095	COG1774	PSP1 C-terminal conserved region
GZH47_RS16100	COG0470	DNA polymerase III
GZH47_RS16105	COG1728	Protein conserved in bacteria
GZH47_RS16110	COG3870	Protein conserved in bacteria
GZH47_RS16115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZH47_RS16120	COG1982	Orn Lys Arg decarboxylase major
GZH47_RS16160	COG3437	response regulator, receiver
GZH47_RS16165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZH47_RS16175	COG0187	DNA topoisomerase II activity
GZH47_RS16190	COG2501	S4 domain
GZH47_RS16195	COG0592	DNA-directed DNA polymerase activity
GZH47_RS16200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZH47_RS16205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZH47_RS16210	COG0594	ribonuclease P activity
GZH47_RS16220	COG1847	R3H domain protein
GZH47_RS16225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GZH47_RS16230	COG0445	tRNA wobble uridine modification
GZH47_RS16235	COG0357	Ribosomal RNA small subunit methyltransferase G
GZH47_RS16240	COG1475	DNA binding
GZH47_RS16245	COG1192	Involved in chromosome partitioning
GZH47_RS16250	COG1475	DNA binding
GZH47_RS16255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GZH47_RS16275	COG4481	Protein conserved in bacteria
GZH47_RS16285	COG2207	Transcriptional regulator
GZH47_RS16285	COG4753	response regulator
GZH47_RS16290	COG3275	phosphorelay sensor kinase activity
GZH47_RS16310	COG4211	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS16320	COG0360	Binds together with S18 to 16S ribosomal RNA
GZH47_RS16325	COG0629	single-stranded DNA binding
GZH47_RS16330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZH47_RS16355	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GZH47_RS16360	COG0359	binds to the 23S rRNA
GZH47_RS16365	COG0305	Participates in initiation and elongation during chromosome replication
GZH47_RS16370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZH47_RS16385	COG0745	RESPONSE REGULATOR receiver
GZH47_RS16390	COG5002	protein histidine kinase activity
GZH47_RS16400	COG4853	Protein conserved in bacteria
GZH47_RS16405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZH47_RS16415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH47_RS16430	COG0640	Transcriptional regulator
GZH47_RS16435	COG0477	Major facilitator Superfamily
GZH47_RS16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS16475	COG1595	DNA-templated transcription, initiation
GZH47_RS16520	COG0577	efflux transmembrane transporter activity
GZH47_RS16585	COG0477	Major facilitator Superfamily
GZH47_RS16610	COG0277	FAD linked oxidase domain protein
GZH47_RS16615	COG2910	NAD(P)H-binding
GZH47_RS16620	COG1733	regulation of RNA biosynthetic process
GZH47_RS16635	COG1309	transcriptional regulator
GZH47_RS16645	COG1733	regulation of RNA biosynthetic process
GZH47_RS16655	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GZH47_RS16660	COG4221	oxidoreductase activity
GZH47_RS16670	COG0322	excinuclease ABC activity
GZH47_RS16695	COG2050	protein possibly involved in aromatic compounds catabolism
GZH47_RS16705	COG0395	ABC-type sugar transport system, permease component
GZH47_RS16715	COG2972	Histidine kinase
GZH47_RS16720	COG2207	Transcriptional regulator
GZH47_RS16720	COG4753	response regulator
GZH47_RS16735	COG2814	Major facilitator Superfamily
GZH47_RS16750	COG0666	response to abiotic stimulus
GZH47_RS16760	COG3437	response regulator, receiver
GZH47_RS16760	COG0784	Response regulator, receiver
GZH47_RS16770	COG4585	Histidine kinase
GZH47_RS16775	COG2197	response regulator
GZH47_RS16800	COG1609	Transcriptional regulator
GZH47_RS16800	COG2207	Transcriptional regulator
GZH47_RS16805	COG0673	inositol 2-dehydrogenase activity
GZH47_RS16815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZH47_RS16830	COG2323	membrane
GZH47_RS16835	COG0326	Molecular chaperone. Has ATPase activity
GZH47_RS16880	COG1301	dicarboxylic acid transport
GZH47_RS16890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZH47_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS16910	COG0736	holo-[acyl-carrier-protein] synthase activity
GZH47_RS16930	COG1349	DNA-binding transcription factor activity
GZH47_RS16950	COG1175	transmembrane transport
GZH47_RS16970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH47_RS16975	COG1764	response to oxidative stress
GZH47_RS16980	COG0583	DNA-binding transcription factor activity
GZH47_RS16985	COG2814	Major facilitator Superfamily
GZH47_RS16990	COG0528	UMP kinase activity
GZH47_RS16995	COG5001	Diguanylate cyclase
GZH47_RS16995	COG3300	MHYT domain
GZH47_RS17000	COG0028	Belongs to the TPP enzyme family
GZH47_RS17020	COG4209	transmembrane transport
GZH47_RS17025	COG0395	ABC-type sugar transport system, permease component
GZH47_RS17060	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS17065	COG2814	Major facilitator Superfamily
GZH47_RS17070	COG1733	regulation of RNA biosynthetic process
GZH47_RS17075	COG1937	Protein conserved in bacteria
GZH47_RS17085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH47_RS17095	COG1132	(ABC) transporter
GZH47_RS17100	COG0789	Transcriptional regulator
GZH47_RS17105	COG2814	Major facilitator Superfamily
GZH47_RS17130	COG4702	Belongs to the UPF0303 family
GZH47_RS17155	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS17165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH47_RS17175	COG2223	nitrite transmembrane transporter activity
GZH47_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS17185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS17190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS17195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS17200	COG0492	ferredoxin-NADP+ reductase activity
GZH47_RS17215	COG2207	Transcriptional regulator
GZH47_RS17240	COG0753	catalase activity
GZH47_RS17245	COG0352	thiamine-phosphate diphosphorylase activity
GZH47_RS17250	COG0351	phosphomethylpyrimidine kinase
GZH47_RS17260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS17265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS17270	COG1116	anion transmembrane transporter activity
GZH47_RS17275	COG0840	transmembrane signaling receptor activity
GZH47_RS17285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZH47_RS17300	COG0840	transmembrane signaling receptor activity
GZH47_RS17305	COG1595	DNA-templated transcription, initiation
GZH47_RS17320	COG0592	DNA-directed DNA polymerase activity
GZH47_RS17330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GZH47_RS17335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZH47_RS17345	COG0383	alpha-mannosidase activity
GZH47_RS17355	COG0492	ferredoxin-NADP+ reductase activity
GZH47_RS17365	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
GZH47_RS17370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZH47_RS17390	COG0730	response to heat
GZH47_RS17410	COG2814	Major facilitator Superfamily
GZH47_RS17420	COG0583	DNA-binding transcription factor activity
GZH47_RS17425	COG0583	DNA-binding transcription factor activity
GZH47_RS17440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZH47_RS17445	COG1278	Cold shock
GZH47_RS17450	COG0628	permease
GZH47_RS17455	COG0784	Response regulator, receiver
GZH47_RS17455	COG2198	Histidine kinase
GZH47_RS17455	COG2205	protein histidine kinase activity
GZH47_RS17460	COG1199	ATP-dependent helicase activity
GZH47_RS17470	COG0622	Phosphoesterase
GZH47_RS17485	COG1902	pentaerythritol trinitrate reductase activity
GZH47_RS17490	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GZH47_RS17535	COG1695	Transcriptional regulator
GZH47_RS17540	COG0772	Belongs to the SEDS family
GZH47_RS17545	COG0673	inositol 2-dehydrogenase activity
GZH47_RS17560	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS17600	COG4895	conserved protein (DUF2196)
GZH47_RS17605	COG2731	YhcH YjgK YiaL family protein
GZH47_RS17610	COG4846	Membrane protein involved in cytochrome C biogenesis
GZH47_RS17615	COG1846	Transcriptional regulator
GZH47_RS17655	COG0457	Tetratricopeptide repeat
GZH47_RS17655	COG0463	Glycosyl transferase, family 2
GZH47_RS17680	COG2353	YceI-like domain
GZH47_RS17685	COG0352	thiamine-phosphate diphosphorylase activity
GZH47_RS17690	COG2022	thiamine diphosphate biosynthetic process
GZH47_RS17700	COG1132	(ABC) transporter
GZH47_RS17715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZH47_RS17725	COG1335	isochorismatase
GZH47_RS17730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS17735	COG0778	Nitroreductase
GZH47_RS17740	COG1959	2 iron, 2 sulfur cluster binding
GZH47_RS17750	COG0746	molybdenum cofactor guanylyltransferase activity
GZH47_RS17755	COG2223	nitrite transmembrane transporter activity
GZH47_RS17760	COG3707	response regulator
GZH47_RS17765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZH47_RS17770	COG2146	nitrite reductase [NAD(P)H] activity
GZH47_RS17775	COG1587	Uroporphyrinogen-III synthase
GZH47_RS17805	COG1472	Belongs to the glycosyl hydrolase 3 family
GZH47_RS17810	COG4209	transmembrane transport
GZH47_RS17815	COG0395	ABC-type sugar transport system, permease component
GZH47_RS17835	COG1472	Belongs to the glycosyl hydrolase 3 family
GZH47_RS17840	COG1609	Transcriptional regulator
GZH47_RS17845	COG2182	Extracellular solute-binding protein
GZH47_RS17850	COG1175	transmembrane transport
GZH47_RS17855	COG3833	ABC-type maltose transport systems, permease component
GZH47_RS17865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH47_RS17865	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH47_RS17875	COG4209	transmembrane transport
GZH47_RS17880	COG0395	ABC-type sugar transport system, permease component
GZH47_RS17895	COG4753	response regulator
GZH47_RS17895	COG2207	Transcriptional regulator
GZH47_RS17900	COG4124	Belongs to the glycosyl hydrolase 26 family
GZH47_RS17910	COG1742	UPF0060 membrane protein
GZH47_RS17930	COG2076	Multidrug Resistance protein
GZH47_RS17945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZH47_RS17960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZH47_RS17965	COG0583	DNA-binding transcription factor activity
GZH47_RS17970	COG2188	Transcriptional regulator
GZH47_RS17975	COG0626	cystathionine gamma-synthase activity
GZH47_RS17980	COG0395	ABC-type sugar transport system, permease component
GZH47_RS17995	COG1801	Protein of unknown function DUF72
GZH47_RS18005	COG3118	belongs to the thioredoxin family
GZH47_RS18015	COG0789	Transcriptional regulator
GZH47_RS18020	COG0012	GTP binding
GZH47_RS18025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZH47_RS18030	COG2890	protein-(glutamine-N5) methyltransferase activity
GZH47_RS18040	COG2814	Major facilitator Superfamily
GZH47_RS18045	COG0009	L-threonylcarbamoyladenylate synthase
GZH47_RS18050	COG1971	Probably functions as a manganese efflux pump
GZH47_RS18060	COG0698	ribose 5-phosphate isomerase
GZH47_RS18065	COG4475	Protein of unknown function (DUF436)
GZH47_RS18070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZH47_RS18090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZH47_RS18105	COG0356	it plays a direct role in the translocation of protons across the membrane
GZH47_RS18115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GZH47_RS18120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZH47_RS18125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZH47_RS18130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZH47_RS18135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZH47_RS18140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZH47_RS18165	COG0463	Glycosyl transferase, family 2
GZH47_RS18185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZH47_RS18195	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZH47_RS18200	COG0649	NAD binding
GZH47_RS18205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GZH47_RS18210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZH47_RS18215	COG0839	Belongs to the complex I subunit 6 family
GZH47_RS18220	COG0713	ATP synthesis coupled electron transport
GZH47_RS18225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZH47_RS18235	COG1007	ATP synthesis coupled electron transport
GZH47_RS18250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH47_RS18255	COG2385	sporulation resulting in formation of a cellular spore
GZH47_RS18260	COG0739	heme binding
GZH47_RS18265	COG1609	Transcriptional regulator
GZH47_RS18275	COG4786	Flagellar basal body rod
GZH47_RS18280	COG4786	Flagellar basal body rod
GZH47_RS18295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZH47_RS18300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZH47_RS18305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH47_RS18320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH47_RS18330	COG2373	Large extracellular alpha-helical protein
GZH47_RS18350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZH47_RS18355	COG1361	Conserved repeat domain
GZH47_RS18355	COG2911	Protein conserved in bacteria
GZH47_RS18355	COG3266	domain, Protein
GZH47_RS18380	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GZH47_RS18405	COG1256	bacterial-type flagellum assembly
GZH47_RS18405	COG4786	Flagellar basal body rod
GZH47_RS18410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZH47_RS18420	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GZH47_RS18425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GZH47_RS18430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZH47_RS18440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GZH47_RS18450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GZH47_RS18465	COG2604	Protein of unknown function DUF115
GZH47_RS18480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZH47_RS18500	COG2089	acid synthase
GZH47_RS18505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZH47_RS18510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GZH47_RS18525	COG1278	Cold shock
GZH47_RS18535	COG0653	protein targeting
GZH47_RS18545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH47_RS18550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GZH47_RS18555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GZH47_RS18560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GZH47_RS18570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZH47_RS18575	COG0137	argininosuccinate synthase activity
GZH47_RS18580	COG0165	Argininosuccinate lyase
GZH47_RS18585	COG2720	vancomycin resistance protein
GZH47_RS18590	COG2884	Cell division ATP-binding protein ftsE
GZH47_RS18595	COG2177	Part of the ABC transporter FtsEX involved in
GZH47_RS18600	COG0739	heme binding
GZH47_RS18605	COG3409	Peptidoglycan-binding domain 1 protein
GZH47_RS18605	COG0793	Belongs to the peptidase S41A family
GZH47_RS18615	COG0556	nucleotide-excision repair
GZH47_RS18620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZH47_RS18625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZH47_RS18640	COG0826	peptidase U32
GZH47_RS18660	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GZH47_RS18665	COG0210	DNA helicase
GZH47_RS18670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZH47_RS18700	COG3880	PFAM UvrB UvrC protein
GZH47_RS18705	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GZH47_RS18710	COG0542	response to heat
GZH47_RS18715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZH47_RS18720	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GZH47_RS18725	COG1183	phosphatidylcholine synthase activity
GZH47_RS18735	COG4956	integral membrane protein (PIN domain superfamily)
GZH47_RS18740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZH47_RS18745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZH47_RS18750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZH47_RS18755	COG1045	serine acetyltransferase
GZH47_RS18760	COG0215	cysteine-tRNA ligase activity
GZH47_RS18765	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GZH47_RS18770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH47_RS18775	COG3688	RNA-binding protein containing a PIN domain
GZH47_RS18785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZH47_RS18790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZH47_RS18795	COG0250	Participates in transcription elongation, termination and antitermination
GZH47_RS18800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZH47_RS18805	COG0081	regulation of translation
GZH47_RS18810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZH47_RS18815	COG0222	ribosome binding
GZH47_RS18820	COG2813	Specifically methylates the guanine in position
GZH47_RS18825	COG0085	RNA polymerase activity
GZH47_RS18830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZH47_RS18835	COG1358	cellular component organization or biogenesis
GZH47_RS18840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZH47_RS18845	COG0049	tRNA binding
GZH47_RS18855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZH47_RS18865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZH47_RS18870	COG0088	Forms part of the polypeptide exit tunnel
GZH47_RS18875	COG0089	rRNA binding
GZH47_RS18880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZH47_RS18885	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZH47_RS18895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZH47_RS18900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZH47_RS18905	COG0255	Belongs to the universal ribosomal protein uL29 family
GZH47_RS18910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GZH47_RS18915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZH47_RS18920	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZH47_RS18925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZH47_RS18935	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZH47_RS18940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZH47_RS18945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GZH47_RS18950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZH47_RS18955	COG1841	ribosomal large subunit assembly
GZH47_RS18960	COG0200	Binds to the 23S rRNA
GZH47_RS18965	COG0201	protein transport
GZH47_RS18970	COG0563	adenylate kinase activity
GZH47_RS18975	COG0024	Methionine aminopeptidase
GZH47_RS18985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GZH47_RS18990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZH47_RS18995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZH47_RS19000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZH47_RS19005	COG0202	RNA polymerase activity
GZH47_RS19010	COG0203	ribosomal protein L17
GZH47_RS19020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZH47_RS19025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GZH47_RS19035	COG2046	Belongs to the sulfate adenylyltransferase family
GZH47_RS19040	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS19045	COG0489	protein tyrosine kinase activity
GZH47_RS19060	COG0726	polysaccharide deacetylase
GZH47_RS19125	COG1120	ATPase activity
GZH47_RS19150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GZH47_RS19155	COG1595	DNA-templated transcription, initiation
GZH47_RS19160	COG5662	AntiSigma factor
GZH47_RS19165	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GZH47_RS19175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH47_RS19205	COG2814	Major facilitator Superfamily
GZH47_RS19210	COG0583	DNA-binding transcription factor activity
GZH47_RS19225	COG1501	Belongs to the glycosyl hydrolase 31 family
GZH47_RS19240	COG3275	phosphorelay sensor kinase activity
GZH47_RS19245	COG2207	Transcriptional regulator
GZH47_RS19245	COG4753	response regulator
GZH47_RS19260	COG0395	ABC-type sugar transport system, permease component
GZH47_RS19265	COG2267	carboxylic ester hydrolase activity
GZH47_RS19270	COG2814	Major facilitator Superfamily
GZH47_RS19275	COG0583	DNA-binding transcription factor activity
GZH47_RS19305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GZH47_RS19320	COG0673	inositol 2-dehydrogenase activity
GZH47_RS19330	COG0673	inositol 2-dehydrogenase activity
GZH47_RS19360	COG4209	transmembrane transport
GZH47_RS19365	COG0395	ABC-type sugar transport system, permease component
GZH47_RS19385	COG1335	isochorismatase
GZH47_RS19390	COG2814	Major facilitator Superfamily
GZH47_RS19410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZH47_RS19430	COG0805	protein transport
GZH47_RS19445	COG4209	transmembrane transport
GZH47_RS19450	COG0395	ABC-type sugar transport system, permease component
GZH47_RS19455	COG1653	transport
GZH47_RS19465	COG0673	inositol 2-dehydrogenase activity
GZH47_RS19500	COG0673	inositol 2-dehydrogenase activity
GZH47_RS19545	COG1063	alcohol dehydrogenase
GZH47_RS19565	COG0386	Belongs to the glutathione peroxidase family
GZH47_RS19575	COG3848	Pyruvate phosphate dikinase
GZH47_RS19575	COG0574	Belongs to the PEP-utilizing enzyme family
GZH47_RS19580	COG2207	Transcriptional regulator
GZH47_RS19585	COG3250	beta-galactosidase activity
GZH47_RS19590	COG2909	trisaccharide binding
GZH47_RS19595	COG1361	Conserved repeat domain
GZH47_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS19625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH47_RS19640	COG1760	l-serine dehydratase
GZH47_RS19645	COG1760	l-serine dehydratase
GZH47_RS19655	COG2972	Histidine kinase
GZH47_RS19660	COG1653	transport
GZH47_RS19665	COG1175	transmembrane transport
GZH47_RS19670	COG0395	ABC-type sugar transport system, permease component
GZH47_RS19685	COG1045	serine acetyltransferase
GZH47_RS19695	COG0454	-acetyltransferase
GZH47_RS19705	COG2207	Transcriptional regulator
GZH47_RS19705	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS19730	COG0673	inositol 2-dehydrogenase activity
GZH47_RS19735	COG0477	Major facilitator Superfamily
GZH47_RS19740	COG1876	peptidase activity
GZH47_RS19760	COG1609	Transcriptional regulator
GZH47_RS19770	COG1175	transmembrane transport
GZH47_RS19785	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GZH47_RS19795	COG4209	transmembrane transport
GZH47_RS19810	COG2972	Histidine kinase
GZH47_RS19815	COG2207	Transcriptional regulator
GZH47_RS19815	COG4753	response regulator
GZH47_RS19860	COG2226	methyltransferase
GZH47_RS19880	COG0706	membrane insertase activity
GZH47_RS19885	COG1733	regulation of RNA biosynthetic process
GZH47_RS19895	COG3384	dioxygenase
GZH47_RS19910	COG4977	sequence-specific DNA binding
GZH47_RS19925	COG1695	Transcriptional regulator
GZH47_RS19955	COG2207	Transcriptional regulator
GZH47_RS19955	COG4753	response regulator
GZH47_RS19960	COG2972	Histidine kinase
GZH47_RS19980	COG4209	transmembrane transport
GZH47_RS19985	COG0395	ABC-type sugar transport system, permease component
GZH47_RS20000	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS20005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH47_RS20025	COG4124	Belongs to the glycosyl hydrolase 26 family
GZH47_RS20040	COG0697	spore germination
GZH47_RS20045	COG0546	phosphoglycolate phosphatase activity
GZH47_RS20055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH47_RS20060	COG1132	(ABC) transporter
GZH47_RS20065	COG1132	(ABC) transporter
GZH47_RS20085	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH47_RS20090	COG3275	phosphorelay sensor kinase activity
GZH47_RS20095	COG1653	transport
GZH47_RS20095	COG1653	transport
GZH47_RS20100	COG4209	transmembrane transport
GZH47_RS20105	COG0395	ABC-type sugar transport system, permease component
GZH47_RS20115	COG2207	Transcriptional regulator
GZH47_RS20160	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GZH47_RS20170	COG1486	melibiose metabolic process
GZH47_RS20175	COG0673	inositol 2-dehydrogenase activity
GZH47_RS20185	COG2207	Transcriptional regulator
GZH47_RS20190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZH47_RS20225	COG1609	Transcriptional regulator
GZH47_RS20270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZH47_RS20385	COG2207	Transcriptional regulator
GZH47_RS20385	COG3708	Transcriptional regulator
GZH47_RS20395	COG2814	Major facilitator Superfamily
GZH47_RS20400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS20410	COG0601	transmembrane transport
GZH47_RS20415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS20425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS20430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS20460	COG2514	catechol 2,3-dioxygenase activity
GZH47_RS20465	COG1132	(ABC) transporter
GZH47_RS20470	COG1132	(ABC) transporter
GZH47_RS20475	COG0861	Integral membrane protein TerC family
GZH47_RS20500	COG2972	Histidine kinase
GZH47_RS20505	COG2207	Transcriptional regulator
GZH47_RS20510	COG4209	transmembrane transport
GZH47_RS20515	COG0395	ABC-type sugar transport system, permease component
GZH47_RS20520	COG1653	transport
GZH47_RS20545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS20555	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS20570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZH47_RS20585	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS20595	COG3850	Histidine kinase
GZH47_RS20595	COG5002	protein histidine kinase activity
GZH47_RS20600	COG0745	RESPONSE REGULATOR receiver
GZH47_RS20605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GZH47_RS20610	COG0463	Glycosyl transferase, family 2
GZH47_RS20620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH47_RS20635	COG3152	Membrane
GZH47_RS20640	COG2267	carboxylic ester hydrolase activity
GZH47_RS20645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZH47_RS20665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GZH47_RS20670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZH47_RS20695	COG2801	Transposase and inactivated derivatives
GZH47_RS20715	COG4209	transmembrane transport
GZH47_RS20720	COG0395	ABC-type sugar transport system, permease component
GZH47_RS20725	COG1653	transport
GZH47_RS20740	COG2059	Chromate
GZH47_RS20745	COG1522	sequence-specific DNA binding
GZH47_RS20760	COG3842	ATPase activity
GZH47_RS20765	COG1176	ABC-type spermidine putrescine transport system, permease component I
GZH47_RS20770	COG1177	transmembrane transport
GZH47_RS20775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZH47_RS20800	COG3534	alpha-L-arabinofuranosidase
GZH47_RS20815	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS20820	COG0671	phosphoesterase, PA-phosphatase related
GZH47_RS20845	COG0667	Aldo Keto reductase
GZH47_RS20855	COG3285	dna ligase
GZH47_RS20855	COG1793	dna ligase
GZH47_RS20865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GZH47_RS20880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH47_RS20885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GZH47_RS20890	COG0802	atpase or kinase
GZH47_RS20895	COG1214	PFAM Peptidase M22, glycoprotease
GZH47_RS20900	COG0456	acetyltransferase
GZH47_RS20905	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZH47_RS20910	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS20920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZH47_RS20930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZH47_RS20940	COG2207	Transcriptional regulator
GZH47_RS20940	COG3708	Transcriptional regulator
GZH47_RS20955	COG0488	(ABC) transporter
GZH47_RS20960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZH47_RS20965	COG0315	cyclic pyranopterin monophosphate synthase activity
GZH47_RS20970	COG0521	Mo-molybdopterin cofactor biosynthetic process
GZH47_RS20980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZH47_RS20985	COG0805	protein transport
GZH47_RS20990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS20995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS21000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS21005	COG1120	ATPase activity
GZH47_RS21010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZH47_RS21015	COG0459	protein refolding
GZH47_RS21020	COG0640	Transcriptional regulator
GZH47_RS21025	COG0346	lactoylglutathione lyase activity
GZH47_RS21030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZH47_RS21035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZH47_RS21060	COG5002	protein histidine kinase activity
GZH47_RS21075	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21085	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21115	COG1073	alpha beta
GZH47_RS21130	COG2207	Transcriptional regulator
GZH47_RS21135	COG3119	arylsulfatase activity
GZH47_RS21160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZH47_RS21170	COG3708	Transcriptional regulator
GZH47_RS21170	COG2207	Transcriptional regulator
GZH47_RS21180	COG0640	Transcriptional regulator
GZH47_RS21185	COG5658	integral membrane protein
GZH47_RS21195	COG0523	cobalamin synthesis protein
GZH47_RS21200	COG0523	cobalamin synthesis protein
GZH47_RS21210	COG1605	Chorismate mutase
GZH47_RS21210	COG0287	Prephenate dehydrogenase
GZH47_RS21220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZH47_RS21230	COG0180	Tryptophanyl-tRNA synthetase
GZH47_RS21235	COG2972	Histidine kinase
GZH47_RS21250	COG1175	transmembrane transport
GZH47_RS21260	COG0477	Major facilitator Superfamily
GZH47_RS21270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS21275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS21295	COG1802	Transcriptional regulator
GZH47_RS21300	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS21305	COG5285	phytanoyl-CoA dioxygenase
GZH47_RS21315	COG4209	transmembrane transport
GZH47_RS21320	COG0395	ABC-type sugar transport system, permease component
GZH47_RS21330	COG2207	Transcriptional regulator
GZH47_RS21330	COG4753	response regulator
GZH47_RS21335	COG3275	phosphorelay sensor kinase activity
GZH47_RS21345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GZH47_RS21350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZH47_RS21355	COG0864	Transcriptional regulator
GZH47_RS21360	COG2337	Toxic component of a toxin-antitoxin (TA) module
GZH47_RS21365	COG4209	transmembrane transport
GZH47_RS21370	COG0395	ABC-type sugar transport system, permease component
GZH47_RS21380	COG2972	Histidine kinase
GZH47_RS21450	COG0006	proline dipeptidase activity
GZH47_RS21455	COG1312	Catalyzes the dehydration of D-mannonate
GZH47_RS21470	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21475	COG2207	Transcriptional regulator
GZH47_RS21475	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS21480	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS21485	COG2318	DinB family
GZH47_RS21490	COG1595	DNA-templated transcription, initiation
GZH47_RS21510	COG1131	(ABC) transporter
GZH47_RS21515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZH47_RS21530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH47_RS21535	COG0154	amidase activity
GZH47_RS21540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH47_RS21550	COG0735	belongs to the Fur family
GZH47_RS21685	COG1842	Phage shock protein A
GZH47_RS21690	COG1983	PspC domain protein
GZH47_RS21695	COG1842	Phage shock protein A
GZH47_RS21700	COG4585	Histidine kinase
GZH47_RS21705	COG2197	response regulator
GZH47_RS21710	COG1763	Mo-molybdopterin cofactor biosynthetic process
GZH47_RS21735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GZH47_RS21745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZH47_RS21760	COG1609	Transcriptional regulator
GZH47_RS21765	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21775	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21780	COG0673	inositol 2-dehydrogenase activity
GZH47_RS21790	COG0569	domain protein
GZH47_RS21795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH47_RS21800	COG1940	carbohydrate kinase activity
GZH47_RS21810	COG2059	Chromate
GZH47_RS21830	COG3275	phosphorelay sensor kinase activity
GZH47_RS21840	COG0366	Alpha amylase catalytic
GZH47_RS21840	COG1470	cell adhesion involved in biofilm formation
GZH47_RS21845	COG1175	transmembrane transport
GZH47_RS21855	COG2207	Transcriptional regulator
GZH47_RS21855	COG4753	response regulator
GZH47_RS21885	COG1621	beta-fructofuranosidase activity
GZH47_RS21895	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS21900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GZH47_RS21910	COG3537	Alpha-1,2-mannosidase
GZH47_RS21915	COG2204	response regulator
GZH47_RS21920	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GZH47_RS21920	COG2273	Hydrolase Family 16
GZH47_RS21925	COG1376	ErfK ybiS ycfS ynhG family protein
GZH47_RS21930	COG1609	Transcriptional regulator
GZH47_RS21940	COG4209	transmembrane transport
GZH47_RS21945	COG0395	ABC-type sugar transport system, permease component
GZH47_RS21955	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS21970	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GZH47_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS21980	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS21985	COG0667	Aldo Keto reductase
GZH47_RS22005	COG0667	Aldo Keto reductase
GZH47_RS22010	COG0697	spore germination
GZH47_RS22015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GZH47_RS22030	COG0210	DNA helicase
GZH47_RS22040	COG0739	heme binding
GZH47_RS22045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZH47_RS22050	COG4470	Protein conserved in bacteria
GZH47_RS22055	COG1132	(ABC) transporter
GZH47_RS22060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZH47_RS22065	COG3314	Sporulation integral membrane protein YlbJ
GZH47_RS22070	COG2346	COG2346, Truncated hemoglobins
GZH47_RS22085	COG3093	addiction module antidote protein HigA
GZH47_RS22095	COG0105	UTP biosynthetic process
GZH47_RS22100	COG0778	Nitroreductase
GZH47_RS22245	COG5646	InterPro IPR014922
GZH47_RS22250	COG1090	epimerase
GZH47_RS22260	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZH47_RS22265	COG0788	formyltetrahydrofolate deformylase activity
GZH47_RS22275	COG3123	guanosine phosphorylase activity
GZH47_RS22285	COG0166	Belongs to the GPI family
GZH47_RS22290	COG1739	Uncharacterized protein family UPF0029
GZH47_RS22295	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GZH47_RS22300	COG4208	sulfate ABC transporter
GZH47_RS22305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GZH47_RS22310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GZH47_RS22325	COG0561	phosphatase activity
GZH47_RS22335	COG4989	oxidoreductase activity
GZH47_RS22340	COG0793	Belongs to the peptidase S41A family
GZH47_RS22340	COG3409	Peptidoglycan-binding domain 1 protein
GZH47_RS22345	COG0517	IMP dehydrogenase activity
GZH47_RS22345	COG0516	GMP reductase activity
GZH47_RS22355	COG0640	Transcriptional regulator
GZH47_RS22360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS22370	COG5285	phytanoyl-CoA dioxygenase
GZH47_RS22380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH47_RS22390	COG0667	Aldo Keto reductase
GZH47_RS22435	COG1482	cell wall glycoprotein biosynthetic process
GZH47_RS22440	COG0346	lactoylglutathione lyase activity
GZH47_RS22445	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GZH47_RS22450	COG1242	4 iron, 4 sulfur cluster binding
GZH47_RS22460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZH47_RS22465	COG0671	phosphoesterase, PA-phosphatase related
GZH47_RS22470	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS22480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZH47_RS22485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZH47_RS22490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZH47_RS22495	COG0006	proline dipeptidase activity
GZH47_RS22510	COG0028	Belongs to the TPP enzyme family
GZH47_RS22515	COG0440	acetolactate synthase activity
GZH47_RS22520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZH47_RS22525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH47_RS22525	COG4191	Histidine kinase
GZH47_RS22530	COG2197	response regulator
GZH47_RS22540	COG0473	3-isopropylmalate dehydrogenase activity
GZH47_RS22545	COG0450	alkyl hydroperoxide reductase
GZH47_RS22555	COG1191	sigma factor activity
GZH47_RS22570	COG3852	Histidine kinase
GZH47_RS22575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GZH47_RS22585	COG1070	Carbohydrate kinase
GZH47_RS22595	COG2124	cytochrome p450
GZH47_RS22600	COG1363	Peptidase, m42
GZH47_RS22625	COG4948	Mandelate Racemase Muconate Lactonizing
GZH47_RS22630	COG1874	Beta-galactosidase
GZH47_RS22635	COG1175	transmembrane transport
GZH47_RS22640	COG0395	ABC-type sugar transport system, permease component
GZH47_RS22645	COG1653	transport
GZH47_RS22650	COG3275	phosphorelay sensor kinase activity
GZH47_RS22655	COG2207	Transcriptional regulator
GZH47_RS22655	COG4753	response regulator
GZH47_RS22680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZH47_RS22685	COG2199	diguanylate cyclase activity
GZH47_RS22685	COG2200	EAL domain
GZH47_RS22705	COG1033	growth of symbiont in host cell
GZH47_RS22705	COG2409	Drug exporters of the RND superfamily
GZH47_RS22710	COG1309	transcriptional regulator
GZH47_RS22725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZH47_RS22735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZH47_RS22740	COG5001	Diguanylate cyclase
GZH47_RS22740	COG3300	MHYT domain
GZH47_RS22755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH47_RS22760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH47_RS22770	COG4585	Histidine kinase
GZH47_RS22785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZH47_RS22795	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GZH47_RS22815	COG1193	negative regulation of DNA recombination
GZH47_RS22820	COG3766	membrane
GZH47_RS22830	COG0477	Major facilitator Superfamily
GZH47_RS22835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZH47_RS22840	COG5337	Spore coat protein CotH
GZH47_RS22870	COG1522	sequence-specific DNA binding
GZH47_RS22875	COG0436	Aminotransferase
GZH47_RS22885	COG2096	Adenosyltransferase
GZH47_RS22890	COG0564	pseudouridine synthase activity
GZH47_RS22895	COG1393	Belongs to the ArsC family
GZH47_RS22900	COG0436	Aminotransferase
GZH47_RS22910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH47_RS22945	COG0673	inositol 2-dehydrogenase activity
GZH47_RS22990	COG0300	oxidoreductase activity
GZH47_RS23005	COG1131	(ABC) transporter
GZH47_RS23010	COG4473	ABC transporter
GZH47_RS23015	COG0456	acetyltransferase
GZH47_RS23020	COG0583	DNA-binding transcription factor activity
GZH47_RS23025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GZH47_RS23030	COG0765	amino acid transport
GZH47_RS23035	COG0765	amino acid transport
GZH47_RS23040	COG1126	abc transporter atp-binding protein
GZH47_RS23045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS23050	COG1473	amidohydrolase
GZH47_RS23060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH47_RS23100	COG0513	Belongs to the DEAD box helicase family
GZH47_RS23105	COG0688	phosphatidylethanolamine metabolic process
GZH47_RS23115	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS23130	COG3344	reverse transcriptase
GZH47_RS23155	COG0463	Glycosyl transferase, family 2
GZH47_RS23170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GZH47_RS23180	COG1215	transferase activity, transferring glycosyl groups
GZH47_RS23205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GZH47_RS23240	COG1086	Polysaccharide biosynthesis protein
GZH47_RS23245	COG1091	dTDP-4-dehydrorhamnose reductase activity
GZH47_RS23255	COG1216	Glycosyl transferase, family 2
GZH47_RS23275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS23305	COG1216	Glycosyl transferase, family 2
GZH47_RS23305	COG0463	Glycosyl transferase, family 2
GZH47_RS23315	COG0371	Dehydrogenase
GZH47_RS23330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZH47_RS23335	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS23345	COG4753	response regulator
GZH47_RS23345	COG2207	Transcriptional regulator
GZH47_RS23350	COG2972	Histidine kinase
GZH47_RS23365	COG4209	transmembrane transport
GZH47_RS23370	COG0395	ABC-type sugar transport system, permease component
GZH47_RS23380	COG1811	Na channel or pump
GZH47_RS23385	COG0673	inositol 2-dehydrogenase activity
GZH47_RS23400	COG1940	carbohydrate kinase activity
GZH47_RS23415	COG3119	arylsulfatase activity
GZH47_RS23430	COG0747	negative chemotaxis
GZH47_RS23435	COG0601	transmembrane transport
GZH47_RS23440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS23445	COG0444	Belongs to the ABC transporter superfamily
GZH47_RS23450	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS23465	COG0747	negative chemotaxis
GZH47_RS23470	COG0601	transmembrane transport
GZH47_RS23475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS23485	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS23490	COG3119	arylsulfatase activity
GZH47_RS23505	COG2972	Histidine kinase
GZH47_RS23510	COG4209	transmembrane transport
GZH47_RS23515	COG0395	ABC-type sugar transport system, permease component
GZH47_RS23520	COG1653	transport
GZH47_RS23530	COG1470	cell adhesion involved in biofilm formation
GZH47_RS23530	COG0366	Alpha amylase catalytic
GZH47_RS23545	COG1846	Transcriptional regulator
GZH47_RS23555	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GZH47_RS23560	COG1349	DNA-binding transcription factor activity
GZH47_RS23565	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS23570	COG0800	Aldolase
GZH47_RS23580	COG1132	(ABC) transporter
GZH47_RS23585	COG1132	(ABC) transporter
GZH47_RS23590	COG2972	Histidine kinase
GZH47_RS23595	COG2204	response regulator
GZH47_RS23665	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZH47_RS23685	COG1063	alcohol dehydrogenase
GZH47_RS23700	COG2207	Transcriptional regulator
GZH47_RS23710	COG2197	response regulator
GZH47_RS23730	COG2814	Major facilitator Superfamily
GZH47_RS23735	COG2066	Belongs to the glutaminase family
GZH47_RS23750	COG4715	Zinc finger, swim domain protein
GZH47_RS23755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZH47_RS23765	COG0667	Aldo Keto reductase
GZH47_RS23770	COG1653	transport
GZH47_RS23775	COG1175	transmembrane transport
GZH47_RS23780	COG0395	ABC-type sugar transport system, permease component
GZH47_RS23785	COG2972	Histidine kinase
GZH47_RS23790	COG2207	Transcriptional regulator
GZH47_RS23790	COG4753	response regulator
GZH47_RS23795	COG1472	Belongs to the glycosyl hydrolase 3 family
GZH47_RS23830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZH47_RS23835	COG1940	carbohydrate kinase activity
GZH47_RS23850	COG0477	Major facilitator Superfamily
GZH47_RS23860	COG4533	DNA binding
GZH47_RS23870	COG2318	DinB family
GZH47_RS23885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZH47_RS23890	COG1012	belongs to the aldehyde dehydrogenase family
GZH47_RS23910	COG0385	Bile acid
GZH47_RS23915	COG5002	protein histidine kinase activity
GZH47_RS23920	COG0745	RESPONSE REGULATOR receiver
GZH47_RS23925	COG1082	Xylose isomerase domain protein TIM barrel
GZH47_RS23935	COG0673	inositol 2-dehydrogenase activity
GZH47_RS23945	COG1012	belongs to the aldehyde dehydrogenase family
GZH47_RS23950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZH47_RS23960	COG0493	'glutamate synthase
GZH47_RS23980	COG0488	(ABC) transporter
GZH47_RS23985	COG0477	Major facilitator Superfamily
GZH47_RS24025	COG1476	TRANSCRIPTIONal
GZH47_RS24040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH47_RS24050	COG1294	oxidase, subunit
GZH47_RS24055	COG1271	oxidase subunit
GZH47_RS24065	COG2972	Histidine kinase
GZH47_RS24070	COG2207	Transcriptional regulator
GZH47_RS24070	COG4753	response regulator
GZH47_RS24080	COG1175	transmembrane transport
GZH47_RS24085	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24105	COG2207	Transcriptional regulator
GZH47_RS24110	COG1653	transport
GZH47_RS24115	COG4209	transmembrane transport
GZH47_RS24120	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24125	COG2363	Small membrane protein
GZH47_RS24130	COG4221	oxidoreductase activity
GZH47_RS24140	COG0745	RESPONSE REGULATOR receiver
GZH47_RS24145	COG2205	protein histidine kinase activity
GZH47_RS24150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZH47_RS24160	COG4209	transmembrane transport
GZH47_RS24165	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH47_RS24180	COG2207	Transcriptional regulator
GZH47_RS24180	COG4753	response regulator
GZH47_RS24180	COG4753	response regulator
GZH47_RS24180	COG2207	Transcriptional regulator
GZH47_RS24185	COG2972	Histidine kinase
GZH47_RS24215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GZH47_RS24220	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZH47_RS24240	COG0673	inositol 2-dehydrogenase activity
GZH47_RS24245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GZH47_RS24255	COG0778	Nitroreductase
GZH47_RS24275	COG0697	spore germination
GZH47_RS24280	COG4753	response regulator
GZH47_RS24280	COG2207	Transcriptional regulator
GZH47_RS24290	COG2207	Transcriptional regulator
GZH47_RS24290	COG4753	response regulator
GZH47_RS24300	COG4209	transmembrane transport
GZH47_RS24305	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24310	COG2382	esterase
GZH47_RS24310	COG3507	Belongs to the glycosyl hydrolase 43 family
GZH47_RS24310	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS24315	COG3507	Belongs to the glycosyl hydrolase 43 family
GZH47_RS24320	COG3507	Belongs to the glycosyl hydrolase 43 family
GZH47_RS24330	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS24340	COG5002	protein histidine kinase activity
GZH47_RS24340	COG2198	Histidine kinase
GZH47_RS24340	COG0784	Response regulator, receiver
GZH47_RS24350	COG2409	Drug exporters of the RND superfamily
GZH47_RS24375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZH47_RS24380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZH47_RS24385	COG1845	cytochrome c oxidase, subunit III
GZH47_RS24390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GZH47_RS24400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS24405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH47_RS24410	COG1120	ATPase activity
GZH47_RS24420	COG0601	transmembrane transport
GZH47_RS24425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH47_RS24430	COG0444	Belongs to the ABC transporter superfamily
GZH47_RS24435	COG4608	Belongs to the ABC transporter superfamily
GZH47_RS24455	COG2988	succinylglutamate desuccinylase activity
GZH47_RS24465	COG0671	phosphoesterase, PA-phosphatase related
GZH47_RS24470	COG0463	Glycosyl transferase, family 2
GZH47_RS24495	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GZH47_RS24505	COG3511	phospholipase C
GZH47_RS24515	COG3973	AAA domain
GZH47_RS24525	COG2814	Major facilitator Superfamily
GZH47_RS24540	COG0673	inositol 2-dehydrogenase activity
GZH47_RS24565	COG1472	Belongs to the glycosyl hydrolase 3 family
GZH47_RS24590	COG1070	Carbohydrate kinase
GZH47_RS24595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH47_RS24600	COG1349	DNA-binding transcription factor activity
GZH47_RS24605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GZH47_RS24610	COG1940	carbohydrate kinase activity
GZH47_RS24615	COG1653	transport
GZH47_RS24620	COG1175	transmembrane transport
GZH47_RS24625	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24650	COG3395	kinase activity
GZH47_RS24655	COG1349	DNA-binding transcription factor activity
GZH47_RS24665	COG0697	spore germination
GZH47_RS24720	COG0251	oxidation-reduction process
GZH47_RS24740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH47_RS24760	COG2972	Histidine kinase
GZH47_RS24790	COG0673	inositol 2-dehydrogenase activity
GZH47_RS24795	COG0673	inositol 2-dehydrogenase activity
GZH47_RS24805	COG1175	transmembrane transport
GZH47_RS24810	COG0395	ABC-type sugar transport system, permease component
GZH47_RS24825	COG0456	acetyltransferase
GZH47_RS24850	COG0698	ribose 5-phosphate isomerase
GZH47_RS24895	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS24910	COG0492	ferredoxin-NADP+ reductase activity
GZH47_RS24945	COG1595	DNA-templated transcription, initiation
GZH47_RS24965	COG2084	Dehydrogenase
GZH47_RS24970	COG0673	inositol 2-dehydrogenase activity
GZH47_RS24985	COG2017	converts alpha-aldose to the beta-anomer
GZH47_RS24990	COG1609	Transcriptional regulator
GZH47_RS25005	COG2207	Transcriptional regulator
GZH47_RS25005	COG4753	response regulator
GZH47_RS25015	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS25020	COG2972	Histidine kinase
GZH47_RS25025	COG4753	response regulator
GZH47_RS25025	COG2207	Transcriptional regulator
GZH47_RS25040	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS25050	COG1397	ADP-ribosylglycohydrolase
GZH47_RS25065	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS25100	COG1175	transmembrane transport
GZH47_RS25120	COG0745	RESPONSE REGULATOR receiver
GZH47_RS25125	COG3850	Histidine kinase
GZH47_RS25125	COG5002	protein histidine kinase activity
GZH47_RS25130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZH47_RS25135	COG2226	methyltransferase
GZH47_RS25140	COG2814	Major facilitator Superfamily
GZH47_RS25145	COG0697	spore germination
GZH47_RS25160	COG0814	amino acid
GZH47_RS25170	COG2207	Transcriptional regulator
GZH47_RS25170	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS25180	COG2814	Major facilitator Superfamily
GZH47_RS25220	COG4209	transmembrane transport
GZH47_RS25225	COG0395	ABC-type sugar transport system, permease component
GZH47_RS25240	COG3345	alpha-galactosidase
GZH47_RS25245	COG0662	Cupin 2, conserved barrel domain protein
GZH47_RS25250	COG0673	inositol 2-dehydrogenase activity
GZH47_RS25275	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GZH47_RS25285	COG0494	nUDIX hydrolase
GZH47_RS25290	COG1175	transmembrane transport
GZH47_RS25295	COG0395	ABC-type sugar transport system, permease component
GZH47_RS25300	COG1653	transport
GZH47_RS25330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZH47_RS25355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH47_RS25360	COG2267	carboxylic ester hydrolase activity
GZH47_RS25380	COG0726	polysaccharide deacetylase
GZH47_RS25380	COG1649	PFAM Uncharacterised BCR, COG1649
GZH47_RS25400	COG0583	DNA-binding transcription factor activity
GZH47_RS25440	COG0131	Imidazoleglycerol-phosphate dehydratase
GZH47_RS25480	COG1733	regulation of RNA biosynthetic process
GZH47_RS25485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZH47_RS25495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZH47_RS25500	COG0561	phosphatase activity
GZH47_RS25510	COG2378	regulation of single-species biofilm formation
GZH47_RS25525	COG1309	transcriptional regulator
GZH47_RS25560	COG0738	Major facilitator superfamily
GZH47_RS25565	COG1247	-acetyltransferase
GZH47_RS25590	COG1595	DNA-templated transcription, initiation
GZH47_RS25625	COG0300	oxidoreductase activity
GZH47_RS25630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZH47_RS25640	COG4585	Histidine kinase
GZH47_RS25640	COG2203	Gaf domain
GZH47_RS25645	COG2197	response regulator
GZH47_RS25660	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS25660	COG3347	Dehydrogenase
GZH47_RS25670	COG4806	L-rhamnose isomerase
GZH47_RS25675	COG1070	Carbohydrate kinase
GZH47_RS25680	COG1349	DNA-binding transcription factor activity
GZH47_RS25695	COG1139	Iron-sulfur cluster binding protein
GZH47_RS25700	COG1556	Lactate utilization protein
GZH47_RS25705	COG2186	Transcriptional regulator
GZH47_RS25710	COG3206	protein involved in exopolysaccharide biosynthesis
GZH47_RS25715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZH47_RS25720	COG2357	RelA SpoT domain protein
GZH47_RS25740	COG1501	Belongs to the glycosyl hydrolase 31 family
GZH47_RS25745	COG4209	transmembrane transport
GZH47_RS25750	COG0395	ABC-type sugar transport system, permease component
GZH47_RS25760	COG2972	Histidine kinase
GZH47_RS25770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH47_RS25790	COG3507	Belongs to the glycosyl hydrolase 43 family
GZH47_RS25795	COG2182	Extracellular solute-binding protein
GZH47_RS25800	COG0395	ABC-type sugar transport system, permease component
GZH47_RS25805	COG1175	transmembrane transport
GZH47_RS25840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GZH47_RS25860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZH47_RS25875	COG2207	Transcriptional regulator
GZH47_RS25875	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS25885	COG0586	Pfam SNARE associated Golgi protein
GZH47_RS25895	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS25900	COG2755	lipolytic protein G-D-S-L family
GZH47_RS25900	COG0657	acetylesterase activity
GZH47_RS25920	COG1082	Xylose isomerase domain protein TIM barrel
GZH47_RS25930	COG1609	Transcriptional regulator
GZH47_RS25935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZH47_RS25940	COG1129	ABC transporter
GZH47_RS25945	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS25950	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS25965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH47_RS25975	COG0583	DNA-binding transcription factor activity
GZH47_RS25980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZH47_RS25985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZH47_RS25990	COG0400	carboxylic ester hydrolase activity
GZH47_RS25995	COG0346	lactoylglutathione lyase activity
GZH47_RS26000	COG2259	Doxx family
GZH47_RS26025	COG5002	protein histidine kinase activity
GZH47_RS26030	COG0745	RESPONSE REGULATOR receiver
GZH47_RS26045	COG2207	Transcriptional regulator
GZH47_RS26055	COG1414	Transcriptional regulator
GZH47_RS26060	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS26080	COG2814	Major facilitator Superfamily
GZH47_RS26090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZH47_RS26095	COG0573	inorganic phosphate transmembrane transporter activity
GZH47_RS26100	COG0581	inorganic phosphate transmembrane transporter activity
GZH47_RS26105	COG0840	transmembrane signaling receptor activity
GZH47_RS26110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH47_RS26115	COG0704	Plays a role in the regulation of phosphate uptake
GZH47_RS26120	COG0583	DNA-binding transcription factor activity
GZH47_RS26125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZH47_RS26130	COG0573	inorganic phosphate transmembrane transporter activity
GZH47_RS26135	COG0581	inorganic phosphate transmembrane transporter activity
GZH47_RS26140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH47_RS26145	COG0704	Plays a role in the regulation of phosphate uptake
GZH47_RS26155	COG2200	EAL domain
GZH47_RS26165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZH47_RS26170	COG1971	Probably functions as a manganese efflux pump
GZH47_RS26175	COG0237	dephospho-CoA kinase activity
GZH47_RS26190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZH47_RS26195	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GZH47_RS26210	COG2972	Histidine kinase
GZH47_RS26215	COG4753	response regulator
GZH47_RS26215	COG2207	Transcriptional regulator
GZH47_RS26225	COG4209	transmembrane transport
GZH47_RS26230	COG0395	ABC-type sugar transport system, permease component
GZH47_RS26260	COG1309	transcriptional regulator
GZH47_RS26290	COG0667	Aldo Keto reductase
GZH47_RS26310	COG1132	(ABC) transporter
GZH47_RS26315	COG0395	ABC-type sugar transport system, permease component
GZH47_RS26320	COG1175	transmembrane transport
GZH47_RS26325	COG2182	Extracellular solute-binding protein
GZH47_RS26345	COG4209	transmembrane transport
GZH47_RS26350	COG0395	ABC-type sugar transport system, permease component
GZH47_RS26360	COG2972	Histidine kinase
GZH47_RS26365	COG4753	response regulator
GZH47_RS26365	COG4753	response regulator
GZH47_RS26365	COG2207	Transcriptional regulator
GZH47_RS26365	COG2207	Transcriptional regulator
GZH47_RS26380	COG0745	RESPONSE REGULATOR receiver
GZH47_RS26385	COG5002	protein histidine kinase activity
GZH47_RS26395	COG0840	transmembrane signaling receptor activity
GZH47_RS26425	COG4191	Histidine kinase
GZH47_RS26435	COG2318	DinB family
GZH47_RS26440	COG1649	PFAM Uncharacterised BCR, COG1649
GZH47_RS26445	COG1349	DNA-binding transcription factor activity
GZH47_RS26470	COG0246	Mannitol dehydrogenase
GZH47_RS26475	COG1063	alcohol dehydrogenase
GZH47_RS26480	COG1279	arginine transmembrane transporter activity
GZH47_RS26490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZH47_RS26495	COG1131	(ABC) transporter
GZH47_RS26500	COG0583	DNA-binding transcription factor activity
GZH47_RS26505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GZH47_RS26520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GZH47_RS26540	COG2207	Transcriptional regulator
GZH47_RS26540	COG4753	response regulator
GZH47_RS26545	COG4209	transmembrane transport
GZH47_RS26550	COG0395	ABC-type sugar transport system, permease component
GZH47_RS26560	COG0673	inositol 2-dehydrogenase activity
GZH47_RS26570	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GZH47_RS26580	COG0488	(ABC) transporter
GZH47_RS26585	COG4221	oxidoreductase activity
GZH47_RS26585	COG3321	synthase
GZH47_RS26585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZH47_RS26585	COG0604	alcohol dehydrogenase
GZH47_RS26600	COG2706	6-phosphogluconolactonase activity
GZH47_RS26605	COG5002	protein histidine kinase activity
GZH47_RS26610	COG0745	RESPONSE REGULATOR receiver
GZH47_RS26615	COG1175	transmembrane transport
GZH47_RS26620	COG0395	ABC-type sugar transport system, permease component
GZH47_RS26635	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS26715	COG0583	DNA-binding transcription factor activity
GZH47_RS26720	COG4122	O-methyltransferase activity
GZH47_RS26725	COG0789	Transcriptional regulator
GZH47_RS26740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZH47_RS26745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZH47_RS26760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZH47_RS26790	COG1846	Transcriptional regulator
GZH47_RS26795	COG2814	Major facilitator Superfamily
GZH47_RS26800	COG2140	Oxalate decarboxylase
GZH47_RS26825	COG0463	Glycosyl transferase, family 2
GZH47_RS26825	COG0457	Tetratricopeptide repeat
GZH47_RS26840	COG1136	(ABC) transporter
GZH47_RS26845	COG0577	efflux transmembrane transporter activity
GZH47_RS26850	COG2205	protein histidine kinase activity
GZH47_RS26855	COG0745	RESPONSE REGULATOR receiver
GZH47_RS26860	COG0583	DNA-binding transcription factor activity
GZH47_RS26865	COG1942	4-Oxalocrotonate Tautomerase
GZH47_RS26870	COG2318	DinB family
GZH47_RS26880	COG2814	Major facilitator Superfamily
GZH47_RS26915	COG1335	isochorismatase
GZH47_RS26925	COG0519	Catalyzes the synthesis of GMP from XMP
GZH47_RS26955	COG0583	DNA-binding transcription factor activity
GZH47_RS26975	COG0748	coenzyme F420 binding
GZH47_RS26985	COG1309	transcriptional regulator
GZH47_RS27035	COG3706	GGDEF domain
GZH47_RS27035	COG4251	negative regulation of phosphorylation
GZH47_RS27035	COG2203	Gaf domain
GZH47_RS27035	COG5001	Diguanylate cyclase
GZH47_RS27045	COG2814	Major facilitator Superfamily
GZH47_RS27065	COG2207	Transcriptional regulator
GZH47_RS27080	COG4154	Belongs to the RbsD FucU family
GZH47_RS27105	COG4824	toxin secretion phage lysis holin
GZH47_RS27130	COG2445	Protein of unknown function DUF86
GZH47_RS27155	COG1486	melibiose metabolic process
GZH47_RS27190	COG2801	Transposase and inactivated derivatives
GZH47_RS27195	COG1368	sulfuric ester hydrolase activity
GZH47_RS27200	COG0116	Belongs to the methyltransferase superfamily
GZH47_RS27205	COG4122	O-methyltransferase activity
GZH47_RS27220	COG2249	NAD(P)H dehydrogenase (quinone) activity
GZH47_RS27240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZH47_RS27245	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GZH47_RS27250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZH47_RS27255	COG5401	PFAM Sporulation and spore germination
GZH47_RS27260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GZH47_RS27265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GZH47_RS27270	COG0367	asparagine synthase
GZH47_RS27285	COG0402	S-adenosylhomocysteine deaminase activity
GZH47_RS27290	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS27325	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZH47_RS27330	COG0740	serine-type endopeptidase activity
GZH47_RS27335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZH47_RS27340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZH47_RS27345	COG0470	DNA polymerase III
GZH47_RS27345	COG1067	ATP-dependent peptidase activity
GZH47_RS27355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GZH47_RS27365	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GZH47_RS27375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GZH47_RS27380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZH47_RS27380	COG1648	precorrin-2 dehydrogenase activity
GZH47_RS27395	COG0113	porphobilinogen synthase activity
GZH47_RS27400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZH47_RS27405	COG0564	pseudouridine synthase activity
GZH47_RS27410	COG1388	LysM domain
GZH47_RS27415	COG0525	valine-tRNA ligase activity
GZH47_RS27420	COG0285	dihydrofolate synthase activity
GZH47_RS27425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZH47_RS27435	COG0784	Response regulator, receiver
GZH47_RS27435	COG2205	protein histidine kinase activity
GZH47_RS27435	COG5002	protein histidine kinase activity
GZH47_RS27445	COG0840	transmembrane signaling receptor activity
GZH47_RS27450	COG0835	chemotaxis
GZH47_RS27455	COG2198	Histidine kinase
GZH47_RS27455	COG0643	Histidine kinase
GZH47_RS27460	COG4251	negative regulation of phosphorylation
GZH47_RS27460	COG3706	GGDEF domain
GZH47_RS27460	COG5001	Diguanylate cyclase
GZH47_RS27460	COG2203	Gaf domain
GZH47_RS27470	COG0640	Transcriptional regulator
GZH47_RS27485	COG0424	maF-like protein
GZH47_RS27490	COG2003	Belongs to the UPF0758 family
GZH47_RS27495	COG1077	Cell shape determining protein MreB Mrl
GZH47_RS27510	COG0850	regulation of cytokinetic process
GZH47_RS27515	COG2894	cell division
GZH47_RS27520	COG0772	Belongs to the SEDS family
GZH47_RS27535	COG1994	Peptidase M50
GZH47_RS27540	COG1530	ribonuclease E activity
GZH47_RS27545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZH47_RS27550	COG2868	ribosomal protein
GZH47_RS27555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZH47_RS27565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZH47_RS27570	COG4492	Belongs to the UPF0735 family
GZH47_RS27575	COG0460	homoserine dehydrogenase
GZH47_RS27580	COG0083	homoserine kinase activity
GZH47_RS27585	COG0077	Prephenate dehydratase
GZH47_RS27590	COG1388	LysM domain
GZH47_RS27600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GZH47_RS27605	COG0632	four-way junction helicase activity
GZH47_RS27610	COG2255	four-way junction helicase activity
GZH47_RS27620	COG2385	sporulation resulting in formation of a cellular spore
GZH47_RS27620	COG2385	sporulation resulting in formation of a cellular spore
GZH47_RS27625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GZH47_RS27635	COG1862	Preprotein translocase
GZH47_RS27640	COG0671	phosphoesterase, PA-phosphatase related
GZH47_RS27650	COG2323	membrane
GZH47_RS27655	COG2244	polysaccharide biosynthetic process
GZH47_RS27665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH47_RS27665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH47_RS27670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH47_RS27670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH47_RS27675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZH47_RS27680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GZH47_RS27680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZH47_RS27685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH47_RS27690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GZH47_RS27695	COG1490	D-aminoacyl-tRNA deacylase activity
GZH47_RS27700	COG0124	histidyl-tRNA synthetase
GZH47_RS27705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZH47_RS27710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GZH47_RS27725	COG0840	transmembrane signaling receptor activity
GZH47_RS27730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZH47_RS27735	COG1253	flavin adenine dinucleotide binding
GZH47_RS27740	COG0482	sulfurtransferase activity
GZH47_RS27745	COG1959	2 iron, 2 sulfur cluster binding
GZH47_RS27750	COG1104	cysteine desulfurase activity
GZH47_RS27765	COG0628	permease
GZH47_RS27770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZH47_RS27775	COG4472	Bacterial protein of unknown function (DUF965)
GZH47_RS27780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZH47_RS27795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GZH47_RS27800	COG0826	peptidase U32
GZH47_RS27805	COG0826	peptidase U32
GZH47_RS27815	COG2738	Putative neutral zinc metallopeptidase
GZH47_RS27820	COG0789	Transcriptional regulator
GZH47_RS27825	COG0004	ammonium transporteR
GZH47_RS27835	COG5002	protein histidine kinase activity
GZH47_RS27835	COG2176	DNA-directed DNA polymerase activity
GZH47_RS27845	COG2814	Major facilitator Superfamily
GZH47_RS27850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS27855	COG1131	(ABC) transporter
GZH47_RS27870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZH47_RS27875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH47_RS27880	COG1141	Ferredoxin
GZH47_RS27900	COG1376	ErfK ybiS ycfS ynhG family protein
GZH47_RS27905	COG0167	dihydroorotate dehydrogenase activity
GZH47_RS27910	COG2357	RelA SpoT domain protein
GZH47_RS27920	COG1187	pseudouridine synthase activity
GZH47_RS27925	COG0561	phosphatase activity
GZH47_RS27970	COG1011	Hydrolase
GZH47_RS27975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZH47_RS27985	COG1063	alcohol dehydrogenase
GZH47_RS27995	COG0384	phenazine biosynthesis protein PhzF
GZH47_RS28000	COG0720	synthase
GZH47_RS28005	COG0602	queuosine metabolic process
GZH47_RS28010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GZH47_RS28025	COG0720	synthase
GZH47_RS28030	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS28035	COG0420	3'-5' exonuclease activity
GZH47_RS28040	COG4717	serine-type aminopeptidase activity
GZH47_RS28045	COG3949	Membrane
GZH47_RS28050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GZH47_RS28060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH47_RS28090	COG0840	transmembrane signaling receptor activity
GZH47_RS28095	COG3290	protein histidine kinase activity
GZH47_RS28095	COG0840	transmembrane signaling receptor activity
GZH47_RS28110	COG4509	Sortase family
GZH47_RS28130	COG2861	carbohydrate metabolic process
GZH47_RS28135	COG2247	cell wall binding repeat
GZH47_RS28135	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS28155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZH47_RS28175	COG1785	Belongs to the alkaline phosphatase family
GZH47_RS28190	COG0583	DNA-binding transcription factor activity
GZH47_RS28195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZH47_RS28200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZH47_RS28225	COG1609	Transcriptional regulator
GZH47_RS28230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZH47_RS28250	COG1842	Phage shock protein A
GZH47_RS28270	COG2814	Major facilitator Superfamily
GZH47_RS28285	COG4464	protein tyrosine phosphatase activity
GZH47_RS28295	COG0489	protein tyrosine kinase activity
GZH47_RS28300	COG1086	Polysaccharide biosynthesis protein
GZH47_RS28315	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS28330	COG0297	glycogen (starch) synthase activity
GZH47_RS28330	COG0438	transferase activity, transferring glycosyl groups
GZH47_RS28340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZH47_RS28350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZH47_RS28355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH47_RS28360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GZH47_RS28375	COG2207	Transcriptional regulator
GZH47_RS28375	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS28390	COG1132	(ABC) transporter
GZH47_RS28395	COG1349	DNA-binding transcription factor activity
GZH47_RS28400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH47_RS28405	COG1979	alcohol dehydrogenase
GZH47_RS28425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GZH47_RS28430	COG0297	glycogen (starch) synthase activity
GZH47_RS28440	COG4978	Transcriptional regulator
GZH47_RS28440	COG0789	Transcriptional regulator
GZH47_RS28475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZH47_RS28525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GZH47_RS28535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZH47_RS28540	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZH47_RS28545	COG1832	CoA-binding protein
GZH47_RS28555	COG2190	(PTS) system
GZH47_RS28555	COG1263	PTS System
GZH47_RS28555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH47_RS28560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZH47_RS28565	COG0693	protein deglycase activity
GZH47_RS28580	COG3118	belongs to the thioredoxin family
GZH47_RS28590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZH47_RS28595	COG0123	including yeast histone deacetylase and acetoin utilization protein
GZH47_RS28600	COG0454	-acetyltransferase
GZH47_RS28605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZH47_RS28610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH47_RS28615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZH47_RS28625	COG2268	Band 7 protein
GZH47_RS28630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH47_RS28630	COG2207	Transcriptional regulator
GZH47_RS28650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZH47_RS28655	COG2203	Gaf domain
GZH47_RS28655	COG2199	diguanylate cyclase activity
GZH47_RS28675	COG4838	Belongs to the UPF0358 family
GZH47_RS28680	COG0387	Pfam Sodium calcium exchanger
GZH47_RS28685	COG1302	Protein conserved in bacteria
GZH47_RS28690	COG0772	Belongs to the SEDS family
GZH47_RS28700	COG1473	amidohydrolase
GZH47_RS28705	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GZH47_RS28720	COG4550	Control of competence regulator ComK, YlbF/YmcA
GZH47_RS28725	COG4471	UPF0298 protein
GZH47_RS28740	COG0613	PHP domain protein
GZH47_RS28750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GZH47_RS28755	COG2226	methyltransferase
GZH47_RS28765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GZH47_RS28770	COG0646	methionine synthase
GZH47_RS28770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GZH47_RS28775	COG2052	Domain of unknown function (DUF370)
GZH47_RS28780	COG0194	GDP metabolic process
GZH47_RS28785	COG1758	RNA polymerase activity
GZH47_RS28790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZH47_RS28795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZH47_RS28800	COG0242	peptide deformylase activity
GZH47_RS28805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZH47_RS28810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZH47_RS28810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZH47_RS28815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GZH47_RS28820	COG0631	protein serine/threonine phosphatase activity
GZH47_RS28825	COG0515	serine threonine protein kinase
GZH47_RS28825	COG2815	serine threonine protein kinase
GZH47_RS28835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZH47_RS28850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZH47_RS28855	COG1302	Protein conserved in bacteria
GZH47_RS28860	COG1461	Dihydroxyacetone kinase
GZH47_RS28865	COG1307	EDD domain protein, DegV family
GZH47_RS28870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GZH47_RS28880	COG2135	peptidase activity
GZH47_RS28890	COG0235	Class ii aldolase
GZH47_RS28895	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GZH47_RS28900	COG1850	ribulose-bisphosphate carboxylase activity
GZH47_RS28905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZH47_RS28910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GZH47_RS28915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GZH47_RS28920	COG0436	Aminotransferase
GZH47_RS28930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZH47_RS28935	COG0583	DNA-binding transcription factor activity
GZH47_RS28940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZH47_RS28945	COG0066	3-isopropylmalate dehydratase activity
GZH47_RS28950	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS28965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZH47_RS28975	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZH47_RS28980	COG1132	(ABC) transporter
GZH47_RS28985	COG1132	(ABC) transporter
GZH47_RS28990	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GZH47_RS29005	COG1131	(ABC) transporter
GZH47_RS29010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GZH47_RS29020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZH47_RS29030	COG2843	Capsule synthesis protein
GZH47_RS29035	COG0564	pseudouridine synthase activity
GZH47_RS29040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZH47_RS29040	COG0116	Belongs to the methyltransferase superfamily
GZH47_RS29045	COG0745	RESPONSE REGULATOR receiver
GZH47_RS29050	COG5002	protein histidine kinase activity
GZH47_RS29055	COG3620	sequence-specific DNA binding
GZH47_RS29060	COG1657	PFAM Prenyltransferase squalene oxidase
GZH47_RS29065	COG1132	(ABC) transporter
GZH47_RS29070	COG2309	aminopeptidase activity
GZH47_RS29080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GZH47_RS29085	COG2409	Drug exporters of the RND superfamily
GZH47_RS29090	COG0454	-acetyltransferase
GZH47_RS29150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZH47_RS29155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GZH47_RS29160	COG1116	anion transmembrane transporter activity
GZH47_RS29165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH47_RS29170	COG4106	trans-aconitate 2-methyltransferase activity
GZH47_RS29175	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GZH47_RS29180	COG2045	Belongs to the ComB family
GZH47_RS29205	COG1547	Domain of unknown function (DUF309)
GZH47_RS29210	COG0288	reversible hydration of carbon dioxide
GZH47_RS29215	COG4918	Iron-sulphur cluster biosynthesis
GZH47_RS29220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GZH47_RS29230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZH47_RS29235	COG4129	membrane
GZH47_RS29250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GZH47_RS29255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZH47_RS29265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GZH47_RS29270	COG1923	regulation of RNA biosynthetic process
GZH47_RS29275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH47_RS29295	COG0464	growth
GZH47_RS29300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZH47_RS29305	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GZH47_RS29310	COG0789	Transcriptional regulator
GZH47_RS29315	COG0174	glutamine synthetase
GZH47_RS29320	COG1136	(ABC) transporter
GZH47_RS29335	COG1136	(ABC) transporter
GZH47_RS29350	COG1653	transport
GZH47_RS29355	COG1175	transmembrane transport
GZH47_RS29360	COG0395	ABC-type sugar transport system, permease component
GZH47_RS29380	COG1175	transmembrane transport
GZH47_RS29385	COG0395	ABC-type sugar transport system, permease component
GZH47_RS29395	COG4124	Belongs to the glycosyl hydrolase 26 family
GZH47_RS29405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZH47_RS29415	COG4224	UPF0291 protein
GZH47_RS29420	COG0667	Aldo Keto reductase
GZH47_RS29430	COG1011	Hydrolase
GZH47_RS29435	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GZH47_RS29440	COG1410	methionine synthase
GZH47_RS29440	COG0646	methionine synthase
GZH47_RS29445	COG1234	tRNA 3'-trailer cleavage
GZH47_RS29450	COG1988	membrane-bound metal-dependent
GZH47_RS29455	COG1205	dead DEAH box helicase
GZH47_RS29455	COG1111	helicase
GZH47_RS29470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZH47_RS29475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZH47_RS29485	COG1119	ATPase activity
GZH47_RS29490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GZH47_RS29495	COG2815	serine threonine protein kinase
GZH47_RS29495	COG0515	serine threonine protein kinase
GZH47_RS29500	COG0745	RESPONSE REGULATOR receiver
GZH47_RS29505	COG3850	Histidine kinase
GZH47_RS29505	COG5002	protein histidine kinase activity
GZH47_RS29510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GZH47_RS29510	COG3153	acetyltransferase
GZH47_RS29515	COG0456	acetyltransferase
GZH47_RS29525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZH47_RS29525	COG0321	lipoyl(octanoyl) transferase activity
GZH47_RS29530	COG1193	negative regulation of DNA recombination
GZH47_RS29535	COG2860	membrane
GZH47_RS29540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZH47_RS29570	COG1607	acyl-coa hydrolase
GZH47_RS29580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GZH47_RS29585	COG0493	'glutamate synthase
GZH47_RS29630	COG2201	protein-glutamate methylesterase activity
GZH47_RS29640	COG2258	MOSC domain
GZH47_RS29660	COG0674	pyruvate-flavodoxin oxidoreductase activity
GZH47_RS29675	COG0492	ferredoxin-NADP+ reductase activity
GZH47_RS29685	COG1132	(ABC) transporter
GZH47_RS29690	COG1132	(ABC) transporter
GZH47_RS29700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZH47_RS29705	COG0714	Associated with various cellular activities
GZH47_RS29730	COG3195	allantoin biosynthetic process
GZH47_RS29730	COG3648	Uricase
GZH47_RS29755	COG1132	(ABC) transporter
GZH47_RS29765	COG0038	chloride channel
GZH47_RS29785	COG2217	Heavy metal translocating P-type atpase
GZH47_RS29790	COG2608	mercury ion transmembrane transporter activity
GZH47_RS29795	COG1199	ATP-dependent helicase activity
GZH47_RS29805	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GZH47_RS29810	COG0567	Dehydrogenase, E1 component
GZH47_RS29815	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZH47_RS29820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZH47_RS29825	COG0745	RESPONSE REGULATOR receiver
GZH47_RS29830	COG5002	protein histidine kinase activity
GZH47_RS29835	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH47_RS29840	COG1175	transmembrane transport
GZH47_RS29845	COG0395	ABC-type sugar transport system, permease component
GZH47_RS29860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GZH47_RS29885	COG0386	Belongs to the glutathione peroxidase family
GZH47_RS29890	COG0531	amino acid
GZH47_RS29900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GZH47_RS29905	COG2169	Transcriptional regulator
GZH47_RS29910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZH47_RS29915	COG4191	Histidine kinase
GZH47_RS29915	COG0784	Response regulator, receiver
GZH47_RS29920	COG2201	protein-glutamate methylesterase activity
GZH47_RS29950	COG1368	sulfuric ester hydrolase activity
GZH47_RS29960	COG3665	Urea carboxylase-associated protein
GZH47_RS29965	COG0439	Biotin carboxylase
GZH47_RS29985	COG1122	ATPase activity
GZH47_RS29990	COG1122	ATPase activity
GZH47_RS29995	COG1363	Peptidase, m42
GZH47_RS30025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZH47_RS30030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH47_RS30035	COG0390	transport system, permease component
GZH47_RS30040	COG0667	Aldo Keto reductase
GZH47_RS30055	COG1686	Belongs to the peptidase S11 family
GZH47_RS30070	COG0583	DNA-binding transcription factor activity
GZH47_RS30080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZH47_RS30085	COG0010	Belongs to the arginase family
GZH47_RS30095	COG1012	belongs to the aldehyde dehydrogenase family
GZH47_RS30105	COG0673	inositol 2-dehydrogenase activity
GZH47_RS30120	COG3119	arylsulfatase activity
GZH47_RS30125	COG0673	inositol 2-dehydrogenase activity
GZH47_RS30130	COG0529	Catalyzes the synthesis of activated sulfate
GZH47_RS30135	COG3119	arylsulfatase activity
GZH47_RS30140	COG1917	Cupin 2, conserved barrel domain protein
GZH47_RS30140	COG2207	Transcriptional regulator
GZH47_RS30145	COG3119	arylsulfatase activity
GZH47_RS30145	COG3408	Glycogen debranching enzyme
GZH47_RS30150	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GZH47_RS30165	COG0488	(ABC) transporter
GZH47_RS30195	COG0701	Predicted permease
GZH47_RS30200	COG3689	TIGRFAM TIGR03943 family protein
GZH47_RS30230	COG2032	superoxide dismutase activity
GZH47_RS30280	COG2814	Major facilitator Superfamily
GZH47_RS30285	COG1435	thymidine kinase activity
GZH47_RS30305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH47_RS30310	COG0697	spore germination
GZH47_RS30330	COG0488	(ABC) transporter
GZH47_RS30335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZH47_RS30355	COG0747	negative chemotaxis
GZH47_RS30365	COG0442	prolyl-tRNA aminoacylation
GZH47_RS30375	COG0789	Transcriptional regulator
GZH47_RS30380	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS30415	COG1131	(ABC) transporter
GZH47_RS30445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZH47_RS30445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZH47_RS30450	COG1929	Belongs to the glycerate kinase type-1 family
GZH47_RS30475	COG0011	TIGRFAM Protein of
GZH47_RS30490	COG1511	domain protein
GZH47_RS30495	COG0789	Transcriptional regulator
GZH47_RS30515	COG2207	Transcriptional regulator
GZH47_RS30515	COG4753	response regulator
GZH47_RS30520	COG2972	Histidine kinase
GZH47_RS30530	COG4209	transmembrane transport
GZH47_RS30535	COG0395	ABC-type sugar transport system, permease component
GZH47_RS30595	COG2267	carboxylic ester hydrolase activity
GZH47_RS30605	COG2972	Histidine kinase
GZH47_RS30610	COG4753	response regulator
GZH47_RS30610	COG2207	Transcriptional regulator
GZH47_RS30615	COG1653	transport
GZH47_RS30620	COG4209	transmembrane transport
GZH47_RS30625	COG0395	ABC-type sugar transport system, permease component
GZH47_RS30645	COG3693	PFAM glycoside hydrolase, family 10
GZH47_RS30665	COG0025	NhaP-type Na H and K H
GZH47_RS30700	COG2816	NAD+ diphosphatase activity
GZH47_RS30705	COG2816	NAD+ diphosphatase activity
GZH47_RS30710	COG1132	(ABC) transporter
GZH47_RS30720	COG0124	histidyl-tRNA synthetase
GZH47_RS30730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GZH47_RS30735	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS30765	COG1126	abc transporter atp-binding protein
GZH47_RS30770	COG0765	amino acid transport
GZH47_RS30780	COG3852	Histidine kinase
GZH47_RS30790	COG1125	glycine betaine transport
GZH47_RS30790	COG0517	IMP dehydrogenase activity
GZH47_RS30795	COG1174	glycine betaine transport
GZH47_RS30800	COG1732	Glycine betaine
GZH47_RS30805	COG1174	glycine betaine transport
GZH47_RS30810	COG0813	purine-nucleoside phosphorylase activity
GZH47_RS30825	COG0393	Putative heavy-metal-binding
GZH47_RS30840	COG0697	spore germination
GZH47_RS30850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZH47_RS30855	COG1956	GAF domain-containing protein
GZH47_RS30870	COG0833	amino acid
GZH47_RS30905	COG2207	Transcriptional regulator
GZH47_RS30910	COG1653	transport
GZH47_RS30965	COG0673	inositol 2-dehydrogenase activity
GZH47_RS30995	COG3858	chitin binding
GZH47_RS31000	COG0154	amidase activity
GZH47_RS31015	COG1361	Conserved repeat domain
GZH47_RS31030	COG2972	Histidine kinase
GZH47_RS31040	COG1129	ABC transporter
GZH47_RS31045	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZH47_RS31050	COG1879	ABC-type sugar transport system periplasmic component
GZH47_RS31080	COG0583	DNA-binding transcription factor activity
GZH47_RS31085	COG3773	Cell wall hydrolase
GZH47_RS31090	COG4974	Belongs to the 'phage' integrase family
GZH47_RS31100	COG1846	Transcriptional regulator
GZH47_RS31105	COG0477	Major facilitator Superfamily
GZH47_RS31110	COG0667	Aldo Keto reductase
GZH47_RS31125	COG3173	Aminoglycoside phosphotransferase
GZH47_RS31130	COG1703	isobutyryl-CoA mutase activity
GZH47_RS31130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZH47_RS31130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GZH47_RS31135	COG2096	Adenosyltransferase
GZH47_RS31140	COG1051	belongs to the nudix hydrolase family
GZH47_RS31145	COG0018	arginyl-trna synthetase
GZH47_RS31155	COG2244	polysaccharide biosynthetic process
GZH47_RS31185	COG0791	NLP P60 protein
GZH47_RS31190	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS31195	COG0129	dihydroxy-acid dehydratase activity
GZH47_RS31200	COG5285	phytanoyl-CoA dioxygenase
GZH47_RS31205	COG3185	4-Hydroxyphenylpyruvate dioxygenase
GZH47_RS31215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZH47_RS31230	COG3186	Phenylalanine-4-hydroxylase
GZH47_RS31240	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS31245	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS31250	COG0477	Major facilitator Superfamily
GZH47_RS31280	COG0667	Aldo Keto reductase
GZH47_RS31285	COG4221	oxidoreductase activity
GZH47_RS31295	COG1064	alcohol dehydrogenase
GZH47_RS31305	COG0789	Transcriptional regulator
GZH47_RS31365	COG4585	Histidine kinase
GZH47_RS31370	COG0745	RESPONSE REGULATOR receiver
GZH47_RS31385	COG1999	signal sequence binding
GZH47_RS31405	COG2197	response regulator
GZH47_RS31410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH47_RS31415	COG1131	(ABC) transporter
GZH47_RS31450	COG3328	transposase activity
GZH47_RS31500	COG3344	reverse transcriptase
GZH47_RS31555	COG0489	protein tyrosine kinase activity
GZH47_RS31580	COG0539	negative regulation of cytoplasmic translation
GZH47_RS31670	COG0433	COG0433 Predicted ATPase
GZH47_RS31680	COG0739	heme binding
GZH47_RS31725	COG2003	Belongs to the UPF0758 family
GZH47_RS31760	COG3328	transposase activity
GZH47_RS31770	COG3328	transposase activity
GZH47_RS31795	COG1742	UPF0060 membrane protein
GZH47_RS31800	COG0789	Transcriptional regulator
GZH47_RS31820	COG0534	Mate efflux family protein
GZH47_RS31885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZH47_RS31915	COG2972	Histidine kinase
GZH47_RS31920	COG3279	Response regulator of the LytR AlgR family
GZH47_RS31930	COG4209	transmembrane transport
GZH47_RS31935	COG0395	ABC-type sugar transport system, permease component
GZH47_RS31970	COG5492	domain, Protein
GZH47_RS31995	COG4209	transmembrane transport
GZH47_RS32000	COG0395	ABC-type sugar transport system, permease component
GZH47_RS32025	COG4209	transmembrane transport
GZH47_RS32030	COG0395	ABC-type sugar transport system, permease component
GZH47_RS32035	COG2972	Histidine kinase
GZH47_RS32040	COG4753	response regulator
GZH47_RS32040	COG2207	Transcriptional regulator
GZH47_RS32045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZH47_RS32060	COG1414	Transcriptional regulator
GZH47_RS32065	COG1486	melibiose metabolic process
GZH47_RS32070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH47_RS32080	COG1175	transmembrane transport
GZH47_RS32085	COG0395	ABC-type sugar transport system, permease component
GZH47_RS32090	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS32100	COG3386	PFAM SMP-30 Gluconolaconase
GZH47_RS32105	COG0673	inositol 2-dehydrogenase activity
GZH47_RS32115	COG0129	dihydroxy-acid dehydratase activity
GZH47_RS32125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH47_RS32130	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZH47_RS32135	COG1929	Belongs to the glycerate kinase type-1 family
GZH47_RS32140	COG0277	FAD linked oxidase domain protein
GZH47_RS32250	COG2002	toxin-antitoxin pair type II binding
GZH47_RS32290	COG1199	ATP-dependent helicase activity
GZH47_RS32340	COG3480	Lon protease (S16) C-terminal proteolytic domain
GZH47_RS32380	COG1793	dna ligase
GZH47_RS32420	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS32425	COG1028	Short-chain dehydrogenase reductase Sdr
GZH47_RS32430	COG0477	Major facilitator Superfamily
GZH47_RS32435	COG0702	epimerase
GZH47_RS32450	COG0656	L-ascorbic acid biosynthetic process
GZH47_RS32460	COG0667	Aldo Keto reductase
GZH47_RS32465	COG4221	oxidoreductase activity
GZH47_RS32475	COG1064	alcohol dehydrogenase
GZH47_RS32485	COG0789	Transcriptional regulator
GZH47_RS32490	COG0667	Aldo Keto reductase
GZH47_RS32525	COG1074	ATP-dependent DNA helicase activity
GZH47_RS33070	COG0328	RNA-DNA hybrid ribonuclease activity
GZH47_RS33100	COG0328	RNA-DNA hybrid ribonuclease activity
GZH47_RS33165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZH47_RS33175	COG0789	Transcriptional regulator
GZH47_RS33210	COG4512	PFAM Accessory gene regulator B
GZH47_RS33255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH47_RS33325	COG0358	DNA primase activity
GZH47_RS33570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZH47_RS33615	COG0587	DNA-directed DNA polymerase activity
GZH47_RS33690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH47_RS33695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH47_RS33700	COG1780	Probably involved in ribonucleotide reductase function