locus-tag	class	description
IJ21_RS00005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IJ21_RS00015	COG2508	Transcriptional regulator
IJ21_RS00040	COG1079	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS00045	COG3845	ABC transporter
IJ21_RS00055	COG1335	isochorismatase
IJ21_RS00060	COG0010	Belongs to the arginase family
IJ21_RS00065	COG1177	transmembrane transport
IJ21_RS00075	COG3842	ATPase activity
IJ21_RS00095	COG1511	domain protein
IJ21_RS00100	COG1309	transcriptional regulator
IJ21_RS00105	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS00135	COG3299	homolog of phage Mu protein gp47
IJ21_RS00140	COG3628	GPW Gp25 family protein
IJ21_RS00150	COG4193	domain, Protein
IJ21_RS00210	COG0640	Transcriptional regulator
IJ21_RS00230	COG1397	ADP-ribosylglycohydrolase
IJ21_RS00235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IJ21_RS00240	COG3842	ATPase activity
IJ21_RS00245	COG1177	transmembrane transport
IJ21_RS00250	COG1176	ABC-type spermidine putrescine transport system, permease component I
IJ21_RS00255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IJ21_RS00260	COG1725	Transcriptional regulator
IJ21_RS00265	COG1349	DNA-binding transcription factor activity
IJ21_RS00280	COG3507	Belongs to the glycosyl hydrolase 43 family
IJ21_RS00285	COG0395	ABC-type sugar transport system, permease component
IJ21_RS00290	COG1175	transmembrane transport
IJ21_RS00310	COG0395	ABC-type sugar transport system, permease component
IJ21_RS00315	COG1175	transmembrane transport
IJ21_RS00325	COG1653	transport
IJ21_RS00330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IJ21_RS00335	COG2201	protein-glutamate methylesterase activity
IJ21_RS00340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IJ21_RS00350	COG0643	Histidine kinase
IJ21_RS00350	COG2198	Histidine kinase
IJ21_RS00360	COG4974	Belongs to the 'phage' integrase family
IJ21_RS00370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IJ21_RS00375	COG1494	fructose-1,6-bisphosphatase
IJ21_RS00385	COG2376	Dihydroxyacetone kinase
IJ21_RS00390	COG0698	ribose 5-phosphate isomerase
IJ21_RS00395	COG1879	ABC-type sugar transport system periplasmic component
IJ21_RS00400	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS00405	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS00410	COG1129	ABC transporter
IJ21_RS00415	COG1349	DNA-binding transcription factor activity
IJ21_RS00445	COG0395	ABC-type sugar transport system, permease component
IJ21_RS00450	COG4209	transmembrane transport
IJ21_RS00465	COG0673	inositol 2-dehydrogenase activity
IJ21_RS00480	COG4821	SIS domain
IJ21_RS00495	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IJ21_RS00500	COG2081	HI0933 family
IJ21_RS00545	COG0395	ABC-type sugar transport system, permease component
IJ21_RS00550	COG1175	transmembrane transport
IJ21_RS00555	COG1653	transport
IJ21_RS00560	COG0698	ribose 5-phosphate isomerase
IJ21_RS00570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IJ21_RS00575	COG1609	Transcriptional regulator
IJ21_RS00580	COG1959	2 iron, 2 sulfur cluster binding
IJ21_RS00585	COG0702	epimerase
IJ21_RS00595	COG4989	oxidoreductase activity
IJ21_RS00605	COG3654	unkown
IJ21_RS00620	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS00630	COG1802	Transcriptional regulator
IJ21_RS00645	COG1175	transmembrane transport
IJ21_RS00660	COG0662	Cupin 2, conserved barrel domain protein
IJ21_RS00690	COG1940	carbohydrate kinase activity
IJ21_RS00695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IJ21_RS00705	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS00710	COG1129	ABC transporter
IJ21_RS00715	COG1129	ABC transporter
IJ21_RS00720	COG2972	Histidine kinase
IJ21_RS00725	COG2207	Transcriptional regulator
IJ21_RS00725	COG4753	response regulator
IJ21_RS00735	COG3328	transposase activity
IJ21_RS00765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IJ21_RS00770	COG0557	exoribonuclease II activity
IJ21_RS00775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IJ21_RS00780	COG0148	phosphopyruvate hydratase activity
IJ21_RS00790	COG0149	triose-phosphate isomerase activity
IJ21_RS00795	COG0126	phosphoglycerate kinase activity
IJ21_RS00815	COG0740	serine-type endopeptidase activity
IJ21_RS00820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IJ21_RS00825	COG1481	regulation of sporulation
IJ21_RS00830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IJ21_RS00835	COG1660	Displays ATPase and GTPase activities
IJ21_RS00840	COG1940	carbohydrate kinase activity
IJ21_RS00850	COG0457	Tetratricopeptide repeat
IJ21_RS00860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IJ21_RS00865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IJ21_RS00865	COG0140	phosphoribosyl-ATP diphosphatase activity
IJ21_RS00870	COG0107	imidazoleglycerol-phosphate synthase activity
IJ21_RS00875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IJ21_RS00880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IJ21_RS00885	COG0131	Imidazoleglycerol-phosphate dehydratase
IJ21_RS00890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IJ21_RS00895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IJ21_RS00905	COG0110	maltose O-acetyltransferase activity
IJ21_RS00910	COG0546	phosphoglycolate phosphatase activity
IJ21_RS00915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IJ21_RS00920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IJ21_RS00925	COG3842	ATPase activity
IJ21_RS00930	COG2508	Transcriptional regulator
IJ21_RS00935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IJ21_RS00995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IJ21_RS01000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IJ21_RS01005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IJ21_RS01020	COG0254	rRNA binding
IJ21_RS01030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IJ21_RS01035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IJ21_RS01040	COG0191	fructose-bisphosphate aldolase activity
IJ21_RS01050	COG0504	CTP synthase activity
IJ21_RS01055	COG3343	RNA polymerase activity
IJ21_RS01060	COG1404	Belongs to the peptidase S8 family
IJ21_RS01065	COG0018	arginyl-trna synthetase
IJ21_RS01080	COG2207	Transcriptional regulator
IJ21_RS01080	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS01110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IJ21_RS01115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IJ21_RS01135	COG0791	NLP P60 protein
IJ21_RS01140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IJ21_RS01150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IJ21_RS01160	COG1760	l-serine dehydratase
IJ21_RS01165	COG1760	l-serine dehydratase
IJ21_RS01190	COG0708	Exodeoxyribonuclease III
IJ21_RS01205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS01210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS01215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS01235	COG2154	pterin-4-alpha-carbinolamine dehydratase
IJ21_RS01245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IJ21_RS01250	COG1360	Flagellar Motor Protein
IJ21_RS01255	COG5002	protein histidine kinase activity
IJ21_RS01260	COG0590	tRNA wobble adenosine to inosine editing
IJ21_RS01280	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS01280	COG2169	Transcriptional regulator
IJ21_RS01310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IJ21_RS01330	COG0517	IMP dehydrogenase activity
IJ21_RS01330	COG0516	GMP reductase activity
IJ21_RS01370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IJ21_RS01375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IJ21_RS01380	COG1396	sequence-specific DNA binding
IJ21_RS01385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IJ21_RS01390	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IJ21_RS01395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IJ21_RS01400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IJ21_RS01405	COG0512	Glutamine amidotransferase of anthranilate synthase
IJ21_RS01410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IJ21_RS01415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IJ21_RS01420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IJ21_RS01425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IJ21_RS01430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IJ21_RS01435	COG0157	Belongs to the NadC ModD family
IJ21_RS01440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IJ21_RS01445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IJ21_RS01450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IJ21_RS01460	COG0037	tRNA processing
IJ21_RS01465	COG0515	serine threonine protein kinase
IJ21_RS01465	COG2815	serine threonine protein kinase
IJ21_RS01470	COG2304	oxidoreductase activity
IJ21_RS01475	COG1902	pentaerythritol trinitrate reductase activity
IJ21_RS01480	COG2208	phosphoserine phosphatase activity
IJ21_RS01485	COG1098	S1 RNA binding domain
IJ21_RS01505	COG1376	ErfK ybiS ycfS ynhG family protein
IJ21_RS01510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IJ21_RS01520	COG3956	TIGRFAM MazG family protein
IJ21_RS01525	COG2244	polysaccharide biosynthetic process
IJ21_RS01535	COG2002	toxin-antitoxin pair type II binding
IJ21_RS01550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IJ21_RS01555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IJ21_RS01575	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IJ21_RS01580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IJ21_RS01585	COG2088	sporulation resulting in formation of a cellular spore
IJ21_RS01590	COG0251	oxidation-reduction process
IJ21_RS01595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IJ21_RS01600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IJ21_RS01610	COG4466	Protein conserved in bacteria
IJ21_RS01620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IJ21_RS01630	COG3584	3D domain protein
IJ21_RS01630	COG3583	domain protein
IJ21_RS01635	COG0084	hydrolase, TatD family'
IJ21_RS01640	COG1078	dGTPase activity
IJ21_RS01645	COG2002	toxin-antitoxin pair type II binding
IJ21_RS01650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IJ21_RS01655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IJ21_RS01660	COG4467	Involved in initiation control of chromosome replication
IJ21_RS01665	COG1774	PSP1 C-terminal conserved region
IJ21_RS01670	COG0470	DNA polymerase III
IJ21_RS01675	COG1728	Protein conserved in bacteria
IJ21_RS01680	COG3870	Protein conserved in bacteria
IJ21_RS01685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IJ21_RS01690	COG1982	Orn Lys Arg decarboxylase major
IJ21_RS01725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IJ21_RS01730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IJ21_RS01735	COG0189	ligase activity
IJ21_RS01740	COG0187	DNA topoisomerase II activity
IJ21_RS01750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IJ21_RS01755	COG2501	S4 domain
IJ21_RS01760	COG0592	DNA-directed DNA polymerase activity
IJ21_RS01765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IJ21_RS01770	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IJ21_RS01775	COG0594	ribonuclease P activity
IJ21_RS01785	COG1847	R3H domain protein
IJ21_RS01790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IJ21_RS01795	COG0445	tRNA wobble uridine modification
IJ21_RS01800	COG0357	Ribosomal RNA small subunit methyltransferase G
IJ21_RS01805	COG1475	DNA binding
IJ21_RS01810	COG1192	Involved in chromosome partitioning
IJ21_RS01815	COG1475	DNA binding
IJ21_RS01820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IJ21_RS01840	COG0668	transmembrane transport
IJ21_RS01845	COG4481	Protein conserved in bacteria
IJ21_RS01865	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IJ21_RS01870	COG1053	succinate dehydrogenase
IJ21_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS01905	COG1595	DNA-templated transcription, initiation
IJ21_RS01915	COG1960	acyl-CoA dehydrogenase activity
IJ21_RS01920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS01925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS01935	COG1733	regulation of RNA biosynthetic process
IJ21_RS01940	COG0360	Binds together with S18 to 16S ribosomal RNA
IJ21_RS01945	COG0629	single-stranded DNA binding
IJ21_RS01950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IJ21_RS01975	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IJ21_RS01980	COG0359	binds to the 23S rRNA
IJ21_RS01985	COG0305	Participates in initiation and elongation during chromosome replication
IJ21_RS01995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IJ21_RS02005	COG0739	heme binding
IJ21_RS02015	COG5002	protein histidine kinase activity
IJ21_RS02030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IJ21_RS02040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IJ21_RS02045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IJ21_RS02055	COG1361	Conserved repeat domain
IJ21_RS02105	COG1840	ABC-type Fe3 transport system, periplasmic component
IJ21_RS02110	COG3842	ATPase activity
IJ21_RS02115	COG1178	ABC-type Fe3 transport system permease component
IJ21_RS02130	COG0579	oxidoreductase
IJ21_RS02140	COG1215	transferase activity, transferring glycosyl groups
IJ21_RS02145	COG1309	transcriptional regulator
IJ21_RS02175	COG3711	transcriptional antiterminator
IJ21_RS02185	COG0246	Mannitol dehydrogenase
IJ21_RS02195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IJ21_RS02210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IJ21_RS02235	COG3275	phosphorelay sensor kinase activity
IJ21_RS02240	COG3279	Response regulator of the LytR AlgR family
IJ21_RS02245	COG1966	Carbon starvation protein
IJ21_RS02265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IJ21_RS02265	COG2169	Transcriptional regulator
IJ21_RS02270	COG0586	Pfam SNARE associated Golgi protein
IJ21_RS02280	COG1073	alpha beta
IJ21_RS02290	COG3231	kanamycin kinase activity
IJ21_RS02300	COG2608	mercury ion transmembrane transporter activity
IJ21_RS02305	COG2217	Heavy metal translocating P-type atpase
IJ21_RS02320	COG2132	Multicopper oxidase
IJ21_RS02335	COG1846	Transcriptional regulator
IJ21_RS02340	COG2211	Major facilitator Superfamily
IJ21_RS02350	COG0116	Belongs to the methyltransferase superfamily
IJ21_RS02355	COG4977	sequence-specific DNA binding
IJ21_RS02355	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS02365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS02370	COG4607	ABC-type enterochelin transport system periplasmic component
IJ21_RS02375	COG1132	(ABC) transporter
IJ21_RS02380	COG1132	(ABC) transporter
IJ21_RS02395	COG1136	(ABC) transporter
IJ21_RS02395	COG0577	efflux transmembrane transporter activity
IJ21_RS02400	COG2205	protein histidine kinase activity
IJ21_RS02410	COG0745	RESPONSE REGULATOR receiver
IJ21_RS02415	COG5002	protein histidine kinase activity
IJ21_RS02435	COG1904	glucuronate isomerase
IJ21_RS02440	COG1368	sulfuric ester hydrolase activity
IJ21_RS02445	COG5002	protein histidine kinase activity
IJ21_RS02460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IJ21_RS02465	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS02480	COG1132	(ABC) transporter
IJ21_RS02485	COG1132	(ABC) transporter
IJ21_RS02495	COG0733	neurotransmitter:sodium symporter activity
IJ21_RS02500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IJ21_RS02510	COG3693	PFAM glycoside hydrolase, family 10
IJ21_RS02535	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IJ21_RS02540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IJ21_RS02555	COG0463	Glycosyl transferase, family 2
IJ21_RS02560	COG1215	transferase activity, transferring glycosyl groups
IJ21_RS02565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IJ21_RS02580	COG1091	dTDP-4-dehydrorhamnose reductase activity
IJ21_RS02585	COG1216	Glycosyl transferase, family 2
IJ21_RS02590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IJ21_RS02615	COG2076	Multidrug Resistance protein
IJ21_RS02630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IJ21_RS02640	COG1801	Protein of unknown function DUF72
IJ21_RS02645	COG0656	L-ascorbic acid biosynthetic process
IJ21_RS02690	COG0012	GTP binding
IJ21_RS02695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IJ21_RS02700	COG2890	protein-(glutamine-N5) methyltransferase activity
IJ21_RS02715	COG2972	Histidine kinase
IJ21_RS02720	COG4753	response regulator
IJ21_RS02720	COG2207	Transcriptional regulator
IJ21_RS02725	COG4213	ABC transporter substrate-binding protein
IJ21_RS02735	COG4214	carbohydrate transport
IJ21_RS02740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IJ21_RS02755	COG1063	alcohol dehydrogenase
IJ21_RS02760	COG1349	DNA-binding transcription factor activity
IJ21_RS02765	COG1653	transport
IJ21_RS02770	COG1175	transmembrane transport
IJ21_RS02775	COG0395	ABC-type sugar transport system, permease component
IJ21_RS02780	COG1063	alcohol dehydrogenase
IJ21_RS02790	COG4753	response regulator
IJ21_RS02790	COG2207	Transcriptional regulator
IJ21_RS02795	COG2972	Histidine kinase
IJ21_RS02800	COG1063	alcohol dehydrogenase
IJ21_RS02805	COG1070	Carbohydrate kinase
IJ21_RS02810	COG1063	alcohol dehydrogenase
IJ21_RS02815	COG0583	DNA-binding transcription factor activity
IJ21_RS02820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS02825	COG1473	amidohydrolase
IJ21_RS02845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS02855	COG1653	transport
IJ21_RS02860	COG1175	transmembrane transport
IJ21_RS02865	COG0395	ABC-type sugar transport system, permease component
IJ21_RS02870	COG0009	L-threonylcarbamoyladenylate synthase
IJ21_RS02875	COG1971	Probably functions as a manganese efflux pump
IJ21_RS02885	COG0698	ribose 5-phosphate isomerase
IJ21_RS02890	COG4475	Protein of unknown function (DUF436)
IJ21_RS02900	COG2315	Protein conserved in bacteria
IJ21_RS02915	COG1175	transmembrane transport
IJ21_RS02920	COG0395	ABC-type sugar transport system, permease component
IJ21_RS02930	COG3250	beta-galactosidase activity
IJ21_RS02940	COG1621	beta-fructofuranosidase activity
IJ21_RS02945	COG3328	transposase activity
IJ21_RS02965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IJ21_RS02970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IJ21_RS02985	COG0356	it plays a direct role in the translocation of protons across the membrane
IJ21_RS02990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IJ21_RS02995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IJ21_RS03005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IJ21_RS03010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IJ21_RS03015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IJ21_RS03020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IJ21_RS03025	COG4464	protein tyrosine phosphatase activity
IJ21_RS03030	COG0783	Belongs to the Dps family
IJ21_RS03035	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IJ21_RS03045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IJ21_RS03050	COG0649	NAD binding
IJ21_RS03055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IJ21_RS03065	COG0839	Belongs to the complex I subunit 6 family
IJ21_RS03070	COG0713	ATP synthesis coupled electron transport
IJ21_RS03075	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IJ21_RS03085	COG1007	ATP synthesis coupled electron transport
IJ21_RS03095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IJ21_RS03100	COG2385	sporulation resulting in formation of a cellular spore
IJ21_RS03105	COG0739	heme binding
IJ21_RS03110	COG1609	Transcriptional regulator
IJ21_RS03120	COG4786	Flagellar basal body rod
IJ21_RS03135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IJ21_RS03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IJ21_RS03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IJ21_RS03160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IJ21_RS03165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IJ21_RS03170	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS03200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IJ21_RS03220	COG4585	Histidine kinase
IJ21_RS03235	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IJ21_RS03240	COG1040	competence protein
IJ21_RS03260	COG4786	Flagellar basal body rod
IJ21_RS03260	COG1256	bacterial-type flagellum assembly
IJ21_RS03265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IJ21_RS03275	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IJ21_RS03280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IJ21_RS03290	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IJ21_RS03305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IJ21_RS03320	COG1086	Polysaccharide biosynthesis protein
IJ21_RS03325	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
IJ21_RS03340	COG2089	acid synthase
IJ21_RS03345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IJ21_RS03350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IJ21_RS03355	COG1278	Cold shock
IJ21_RS03370	COG0789	Transcriptional regulator
IJ21_RS03385	COG0653	protein targeting
IJ21_RS03390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IJ21_RS03395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IJ21_RS03400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IJ21_RS03405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IJ21_RS03415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IJ21_RS03420	COG0137	argininosuccinate synthase activity
IJ21_RS03425	COG0165	Argininosuccinate lyase
IJ21_RS03435	COG2884	Cell division ATP-binding protein ftsE
IJ21_RS03440	COG2177	Part of the ABC transporter FtsEX involved in
IJ21_RS03445	COG0739	heme binding
IJ21_RS03450	COG0793	Belongs to the peptidase S41A family
IJ21_RS03450	COG3409	Peptidoglycan-binding domain 1 protein
IJ21_RS03465	COG0556	nucleotide-excision repair
IJ21_RS03470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IJ21_RS03475	COG1418	mRNA catabolic process
IJ21_RS03480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IJ21_RS03490	COG1082	Xylose isomerase domain protein TIM barrel
IJ21_RS03495	COG0826	peptidase U32
IJ21_RS03500	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IJ21_RS03505	COG0210	DNA helicase
IJ21_RS03510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IJ21_RS03555	COG3880	PFAM UvrB UvrC protein
IJ21_RS03560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IJ21_RS03565	COG0542	response to heat
IJ21_RS03570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IJ21_RS03575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IJ21_RS03580	COG1183	phosphatidylcholine synthase activity
IJ21_RS03590	COG4956	integral membrane protein (PIN domain superfamily)
IJ21_RS03595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IJ21_RS03600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IJ21_RS03605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IJ21_RS03610	COG1045	serine acetyltransferase
IJ21_RS03615	COG0215	cysteine-tRNA ligase activity
IJ21_RS03620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IJ21_RS03625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IJ21_RS03640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IJ21_RS03645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IJ21_RS03650	COG0250	Participates in transcription elongation, termination and antitermination
IJ21_RS03655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IJ21_RS03660	COG0081	regulation of translation
IJ21_RS03665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IJ21_RS03670	COG0222	ribosome binding
IJ21_RS03675	COG2813	Specifically methylates the guanine in position
IJ21_RS03680	COG0085	RNA polymerase activity
IJ21_RS03685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IJ21_RS03690	COG1358	cellular component organization or biogenesis
IJ21_RS03695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IJ21_RS03700	COG0049	tRNA binding
IJ21_RS03705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IJ21_RS03710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IJ21_RS03720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IJ21_RS03725	COG0088	Forms part of the polypeptide exit tunnel
IJ21_RS03730	COG0089	rRNA binding
IJ21_RS03735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IJ21_RS03740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IJ21_RS03745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IJ21_RS03750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IJ21_RS03755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IJ21_RS03760	COG0255	Belongs to the universal ribosomal protein uL29 family
IJ21_RS03765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IJ21_RS03770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IJ21_RS03775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IJ21_RS03780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IJ21_RS03785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IJ21_RS03790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IJ21_RS03795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IJ21_RS03800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IJ21_RS03805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IJ21_RS03810	COG1841	ribosomal large subunit assembly
IJ21_RS03815	COG0200	Binds to the 23S rRNA
IJ21_RS03820	COG0201	protein transport
IJ21_RS03825	COG0563	adenylate kinase activity
IJ21_RS03830	COG0024	Methionine aminopeptidase
IJ21_RS03835	COG2163	COG2163 Ribosomal protein L14E L6E L27E
IJ21_RS03840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IJ21_RS03845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IJ21_RS03850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IJ21_RS03855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IJ21_RS03860	COG0202	RNA polymerase activity
IJ21_RS03865	COG0203	ribosomal protein L17
IJ21_RS03870	COG0101	tRNA pseudouridine synthase activity
IJ21_RS03875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IJ21_RS03880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IJ21_RS03885	COG0175	sulfate reduction
IJ21_RS03890	COG2046	Belongs to the sulfate adenylyltransferase family
IJ21_RS03895	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS03900	COG0489	protein tyrosine kinase activity
IJ21_RS03910	COG2194	sulfuric ester hydrolase activity
IJ21_RS03915	COG0726	polysaccharide deacetylase
IJ21_RS04005	COG1120	ATPase activity
IJ21_RS04040	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IJ21_RS04045	COG1595	DNA-templated transcription, initiation
IJ21_RS04050	COG5662	AntiSigma factor
IJ21_RS04055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IJ21_RS04065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IJ21_RS04085	COG0747	negative chemotaxis
IJ21_RS04090	COG0601	transmembrane transport
IJ21_RS04095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS04100	COG0444	Belongs to the ABC transporter superfamily
IJ21_RS04120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IJ21_RS04125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IJ21_RS04130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IJ21_RS04135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IJ21_RS04140	COG1733	regulation of RNA biosynthetic process
IJ21_RS04160	COG4209	transmembrane transport
IJ21_RS04165	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04170	COG1653	transport
IJ21_RS04180	COG2972	Histidine kinase
IJ21_RS04185	COG2207	Transcriptional regulator
IJ21_RS04185	COG4753	response regulator
IJ21_RS04190	COG4213	ABC transporter substrate-binding protein
IJ21_RS04200	COG4213	ABC transporter substrate-binding protein
IJ21_RS04210	COG4214	carbohydrate transport
IJ21_RS04215	COG0500	methyltransferase
IJ21_RS04230	COG2972	Histidine kinase
IJ21_RS04240	COG1175	transmembrane transport
IJ21_RS04245	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04250	COG1621	beta-fructofuranosidase activity
IJ21_RS04255	COG2207	Transcriptional regulator
IJ21_RS04255	COG4753	response regulator
IJ21_RS04265	COG4977	sequence-specific DNA binding
IJ21_RS04270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IJ21_RS04275	COG4753	response regulator
IJ21_RS04275	COG2207	Transcriptional regulator
IJ21_RS04290	COG2972	Histidine kinase
IJ21_RS04295	COG4209	transmembrane transport
IJ21_RS04300	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04305	COG1653	transport
IJ21_RS04355	COG1653	transport
IJ21_RS04365	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04385	COG1175	transmembrane transport
IJ21_RS04390	COG3833	ABC-type maltose transport systems, permease component
IJ21_RS04415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IJ21_RS04420	COG1846	Transcriptional regulator
IJ21_RS04430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IJ21_RS04435	COG1733	regulation of RNA biosynthetic process
IJ21_RS04440	COG2814	Major facilitator Superfamily
IJ21_RS04445	COG0656	L-ascorbic acid biosynthetic process
IJ21_RS04450	COG2176	DNA-directed DNA polymerase activity
IJ21_RS04480	COG1131	(ABC) transporter
IJ21_RS04490	COG1309	transcriptional regulator
IJ21_RS04500	COG3832	glyoxalase III activity
IJ21_RS04505	COG0640	Transcriptional regulator
IJ21_RS04515	COG0673	inositol 2-dehydrogenase activity
IJ21_RS04535	COG3842	ATPase activity
IJ21_RS04585	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04590	COG4209	transmembrane transport
IJ21_RS04595	COG1653	transport
IJ21_RS04605	COG3328	transposase activity
IJ21_RS04615	COG5566	PFAM Mor transcription activator
IJ21_RS04620	COG1737	Transcriptional regulator
IJ21_RS04640	COG0659	secondary active sulfate transmembrane transporter activity
IJ21_RS04695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IJ21_RS04705	COG0720	synthase
IJ21_RS04715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IJ21_RS04720	COG0765	amino acid transport
IJ21_RS04725	COG0765	amino acid transport
IJ21_RS04730	COG1126	abc transporter atp-binding protein
IJ21_RS04735	COG0456	acetyltransferase
IJ21_RS04740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IJ21_RS04745	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS04755	COG1408	metallophosphoesterase
IJ21_RS04775	COG2378	regulation of single-species biofilm formation
IJ21_RS04785	COG0673	inositol 2-dehydrogenase activity
IJ21_RS04790	COG4209	transmembrane transport
IJ21_RS04795	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04815	COG1126	abc transporter atp-binding protein
IJ21_RS04820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IJ21_RS04825	COG0765	amino acid transport
IJ21_RS04830	COG0765	amino acid transport
IJ21_RS04840	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04845	COG4209	transmembrane transport
IJ21_RS04850	COG2972	Histidine kinase
IJ21_RS04865	COG3250	beta-galactosidase activity
IJ21_RS04900	COG0366	Alpha amylase catalytic
IJ21_RS04920	COG0395	ABC-type sugar transport system, permease component
IJ21_RS04935	COG3559	Exporter of polyketide antibiotics
IJ21_RS04940	COG1131	(ABC) transporter
IJ21_RS04965	COG1309	transcriptional regulator
IJ21_RS04970	COG0745	RESPONSE REGULATOR receiver
IJ21_RS04985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IJ21_RS04990	COG0765	amino acid transport
IJ21_RS04995	COG1126	abc transporter atp-binding protein
IJ21_RS05000	COG2079	MmgE PrpD family protein
IJ21_RS05010	COG1175	transmembrane transport
IJ21_RS05015	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05020	COG2972	Histidine kinase
IJ21_RS05025	COG2207	Transcriptional regulator
IJ21_RS05025	COG4753	response regulator
IJ21_RS05055	COG1053	succinate dehydrogenase
IJ21_RS05065	COG1473	amidohydrolase
IJ21_RS05075	COG3608	succinylglutamate desuccinylase aspartoacylase
IJ21_RS05080	COG0456	acetyltransferase
IJ21_RS05085	COG0778	Nitroreductase
IJ21_RS05095	COG1012	belongs to the aldehyde dehydrogenase family
IJ21_RS05100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IJ21_RS05120	COG0477	Major facilitator Superfamily
IJ21_RS05125	COG1510	regulation of RNA biosynthetic process
IJ21_RS05130	COG0517	IMP dehydrogenase activity
IJ21_RS05130	COG4175	Glycine betaine
IJ21_RS05135	COG4176	ABC-type proline glycine betaine transport system permease component
IJ21_RS05150	COG4149	molybdate abc transporter
IJ21_RS05155	COG0725	ABC transporter, periplasmic molybdate-binding protein
IJ21_RS05165	COG1879	ABC-type sugar transport system periplasmic component
IJ21_RS05170	COG1129	ABC transporter
IJ21_RS05175	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS05180	COG0159	tryptophan synthase activity
IJ21_RS05185	COG1070	Carbohydrate kinase
IJ21_RS05195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IJ21_RS05200	COG1845	cytochrome c oxidase, subunit III
IJ21_RS05205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IJ21_RS05220	COG2207	Transcriptional regulator
IJ21_RS05220	COG4753	response regulator
IJ21_RS05225	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05230	COG1175	transmembrane transport
IJ21_RS05240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IJ21_RS05245	COG1486	melibiose metabolic process
IJ21_RS05270	COG1105	Belongs to the carbohydrate kinase PfkB family
IJ21_RS05290	COG4632	Exopolysaccharide biosynthesis protein
IJ21_RS05290	COG5434	Belongs to the glycosyl hydrolase 28 family
IJ21_RS05300	COG2205	protein histidine kinase activity
IJ21_RS05310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IJ21_RS05310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IJ21_RS05315	COG3459	Glycosyltransferase 36 associated
IJ21_RS05320	COG4209	transmembrane transport
IJ21_RS05325	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05335	COG3275	phosphorelay sensor kinase activity
IJ21_RS05340	COG4753	response regulator
IJ21_RS05340	COG2207	Transcriptional regulator
IJ21_RS05345	COG2267	carboxylic ester hydrolase activity
IJ21_RS05355	COG0457	Tetratricopeptide repeat
IJ21_RS05365	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05370	COG4209	transmembrane transport
IJ21_RS05375	COG2972	Histidine kinase
IJ21_RS05400	COG1803	Methylglyoxal synthase
IJ21_RS05405	COG1686	Belongs to the peptidase S11 family
IJ21_RS05410	COG1174	glycine betaine transport
IJ21_RS05415	COG1732	Glycine betaine
IJ21_RS05420	COG1174	glycine betaine transport
IJ21_RS05425	COG0517	IMP dehydrogenase activity
IJ21_RS05425	COG1125	glycine betaine transport
IJ21_RS05435	COG1741	Belongs to the pirin family
IJ21_RS05440	COG1272	protein, Hemolysin III
IJ21_RS05445	COG1396	sequence-specific DNA binding
IJ21_RS05460	COG2207	Transcriptional regulator
IJ21_RS05465	COG1653	transport
IJ21_RS05470	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05475	COG4209	transmembrane transport
IJ21_RS05480	COG2207	Transcriptional regulator
IJ21_RS05485	COG4209	transmembrane transport
IJ21_RS05490	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05495	COG1653	transport
IJ21_RS05505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IJ21_RS05505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IJ21_RS05520	COG2208	phosphoserine phosphatase activity
IJ21_RS05525	COG1191	sigma factor activity
IJ21_RS05530	COG2172	sigma factor antagonist activity
IJ21_RS05535	COG1366	Belongs to the anti-sigma-factor antagonist family
IJ21_RS05560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IJ21_RS05565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IJ21_RS05570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IJ21_RS05580	COG4840	Belongs to the UPF0435 family
IJ21_RS05590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IJ21_RS05615	COG0577	efflux transmembrane transporter activity
IJ21_RS05620	COG1136	(ABC) transporter
IJ21_RS05645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS05665	COG2183	response to ionizing radiation
IJ21_RS05675	COG3091	SprT-like family
IJ21_RS05685	COG2972	Histidine kinase
IJ21_RS05690	COG4753	response regulator
IJ21_RS05690	COG2207	Transcriptional regulator
IJ21_RS05695	COG4209	transmembrane transport
IJ21_RS05700	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05705	COG1653	transport
IJ21_RS05710	COG1053	succinate dehydrogenase
IJ21_RS05710	COG3976	FMN-binding domain protein
IJ21_RS05730	COG2239	Acts as a magnesium transporter
IJ21_RS05785	COG1472	Belongs to the glycosyl hydrolase 3 family
IJ21_RS05790	COG4209	transmembrane transport
IJ21_RS05795	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05805	COG2972	Histidine kinase
IJ21_RS05810	COG2197	response regulator
IJ21_RS05830	COG1120	ATPase activity
IJ21_RS05835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS05865	COG1653	transport
IJ21_RS05875	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05890	COG1175	transmembrane transport
IJ21_RS05895	COG0395	ABC-type sugar transport system, permease component
IJ21_RS05900	COG2873	o-acetylhomoserine
IJ21_RS05910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS05920	COG1011	Hydrolase
IJ21_RS05925	COG0747	negative chemotaxis
IJ21_RS05935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS05945	COG4608	Belongs to the ABC transporter superfamily
IJ21_RS05950	COG0456	acetyltransferase
IJ21_RS05955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IJ21_RS05960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IJ21_RS05970	COG0318	PFAM AMP-dependent synthetase and ligase
IJ21_RS05995	COG4209	transmembrane transport
IJ21_RS06000	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06005	COG1653	transport
IJ21_RS06010	COG2207	Transcriptional regulator
IJ21_RS06015	COG1069	ribulokinase activity
IJ21_RS06020	COG1968	undecaprenyl-diphosphatase activity
IJ21_RS06035	COG0697	spore germination
IJ21_RS06060	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS06065	COG1609	Transcriptional regulator
IJ21_RS06070	COG0383	alpha-mannosidase activity
IJ21_RS06075	COG1725	Transcriptional regulator
IJ21_RS06080	COG1131	(ABC) transporter
IJ21_RS06115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IJ21_RS06120	COG1609	Transcriptional regulator
IJ21_RS06145	COG0693	protein deglycase activity
IJ21_RS06150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IJ21_RS06180	COG3250	beta-galactosidase activity
IJ21_RS06190	COG3944	biosynthesis protein
IJ21_RS06195	COG0489	protein tyrosine kinase activity
IJ21_RS06200	COG1086	Polysaccharide biosynthesis protein
IJ21_RS06215	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS06230	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS06230	COG0297	glycogen (starch) synthase activity
IJ21_RS06240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IJ21_RS06250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IJ21_RS06255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IJ21_RS06260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IJ21_RS06280	COG2972	Histidine kinase
IJ21_RS06285	COG0745	RESPONSE REGULATOR receiver
IJ21_RS06290	COG4209	transmembrane transport
IJ21_RS06295	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06305	COG1501	Belongs to the glycosyl hydrolase 31 family
IJ21_RS06310	COG5002	protein histidine kinase activity
IJ21_RS06315	COG4977	sequence-specific DNA binding
IJ21_RS06315	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS06320	COG0673	inositol 2-dehydrogenase activity
IJ21_RS06330	COG0745	RESPONSE REGULATOR receiver
IJ21_RS06335	COG5002	protein histidine kinase activity
IJ21_RS06335	COG3850	Histidine kinase
IJ21_RS06345	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS06350	COG3386	PFAM SMP-30 Gluconolaconase
IJ21_RS06355	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IJ21_RS06360	COG1349	DNA-binding transcription factor activity
IJ21_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS06370	COG2340	Cysteine-rich secretory protein family
IJ21_RS06375	COG1388	LysM domain
IJ21_RS06375	COG3584	3D domain protein
IJ21_RS06385	COG3458	cephalosporin-C deacetylase activity
IJ21_RS06390	COG3275	phosphorelay sensor kinase activity
IJ21_RS06395	COG2207	Transcriptional regulator
IJ21_RS06395	COG4753	response regulator
IJ21_RS06400	COG1653	transport
IJ21_RS06420	COG1175	transmembrane transport
IJ21_RS06425	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06440	COG1175	transmembrane transport
IJ21_RS06445	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06465	COG0673	inositol 2-dehydrogenase activity
IJ21_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS06485	COG0179	Fumarylacetoacetate (FAA) hydrolase
IJ21_RS06495	COG0840	transmembrane signaling receptor activity
IJ21_RS06500	COG1929	Belongs to the glycerate kinase type-1 family
IJ21_RS06520	COG0701	Predicted permease
IJ21_RS06525	COG0180	Tryptophanyl-tRNA synthetase
IJ21_RS06540	COG1988	membrane-bound metal-dependent
IJ21_RS06550	COG3773	Cell wall hydrolase
IJ21_RS06575	COG2207	Transcriptional regulator
IJ21_RS06585	COG1175	transmembrane transport
IJ21_RS06590	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06605	COG3328	transposase activity
IJ21_RS06610	COG1312	Catalyzes the dehydration of D-mannonate
IJ21_RS06615	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS06660	COG3655	Transcriptional regulator
IJ21_RS06665	COG3739	integral membrane protein
IJ21_RS06670	COG1132	(ABC) transporter
IJ21_RS06680	COG5002	protein histidine kinase activity
IJ21_RS06695	COG0673	inositol 2-dehydrogenase activity
IJ21_RS06700	COG0561	phosphatase activity
IJ21_RS06705	COG2839	Protein conserved in bacteria
IJ21_RS06715	COG2244	polysaccharide biosynthetic process
IJ21_RS06725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS06735	COG1612	heme a metabolic process
IJ21_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS06750	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IJ21_RS06760	COG1252	NADH dehydrogenase
IJ21_RS06765	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IJ21_RS06770	COG0316	Belongs to the HesB IscA family
IJ21_RS06790	COG0745	RESPONSE REGULATOR receiver
IJ21_RS06795	COG5002	protein histidine kinase activity
IJ21_RS06800	COG1136	(ABC) transporter
IJ21_RS06805	COG0577	efflux transmembrane transporter activity
IJ21_RS06810	COG0189	ligase activity
IJ21_RS06825	COG1252	NADH dehydrogenase
IJ21_RS06835	COG3253	May function as heme-dependent peroxidase
IJ21_RS06855	COG1484	DNA-dependent DNA replication
IJ21_RS06860	COG2972	Histidine kinase
IJ21_RS06870	COG2182	Extracellular solute-binding protein
IJ21_RS06875	COG1175	transmembrane transport
IJ21_RS06880	COG0395	ABC-type sugar transport system, permease component
IJ21_RS06885	COG0322	excinuclease ABC activity
IJ21_RS06895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IJ21_RS06900	COG0569	domain protein
IJ21_RS06905	COG0791	NLP P60 protein
IJ21_RS06910	COG0583	DNA-binding transcription factor activity
IJ21_RS06915	COG2009	succinate dehydrogenase
IJ21_RS06920	COG1053	succinate dehydrogenase
IJ21_RS06925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IJ21_RS06930	COG1733	regulation of RNA biosynthetic process
IJ21_RS06935	COG1741	Belongs to the pirin family
IJ21_RS06955	COG0583	DNA-binding transcription factor activity
IJ21_RS06960	COG2124	cytochrome p450
IJ21_RS06965	COG0598	Magnesium transport protein CorA
IJ21_RS06970	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IJ21_RS06975	COG0626	cystathionine gamma-synthase activity
IJ21_RS06980	COG0626	cystathionine gamma-synthase activity
IJ21_RS06985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IJ21_RS06995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IJ21_RS07000	COG3584	3D domain protein
IJ21_RS07005	COG1595	DNA-templated transcription, initiation
IJ21_RS07010	COG4758	membrane
IJ21_RS07015	COG4585	Histidine kinase
IJ21_RS07020	COG2197	response regulator
IJ21_RS07030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IJ21_RS07035	COG0745	RESPONSE REGULATOR receiver
IJ21_RS07040	COG3850	Histidine kinase
IJ21_RS07040	COG5002	protein histidine kinase activity
IJ21_RS07045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IJ21_RS07050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IJ21_RS07070	COG0745	RESPONSE REGULATOR receiver
IJ21_RS07075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IJ21_RS07080	COG2002	toxin-antitoxin pair type II binding
IJ21_RS07085	COG2207	Transcriptional regulator
IJ21_RS07085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS07090	COG2972	Histidine kinase
IJ21_RS07105	COG2182	Extracellular solute-binding protein
IJ21_RS07110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IJ21_RS07125	COG2766	serine protein kinase
IJ21_RS07145	COG0534	Mate efflux family protein
IJ21_RS07150	COG0840	transmembrane signaling receptor activity
IJ21_RS07160	COG2719	SpoVR family
IJ21_RS07165	COG1657	PFAM Prenyltransferase squalene oxidase
IJ21_RS07170	COG2718	Belongs to the UPF0229 family
IJ21_RS07180	COG3845	ABC transporter
IJ21_RS07185	COG4603	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS07190	COG1079	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS07195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IJ21_RS07200	COG0813	purine-nucleoside phosphorylase activity
IJ21_RS07205	COG2363	Small membrane protein
IJ21_RS07220	COG3377	Domain of unknown function (DUF1805)
IJ21_RS07225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IJ21_RS07230	COG0396	ATPase activity
IJ21_RS07235	COG0719	Fe-S assembly protein
IJ21_RS07240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IJ21_RS07245	COG0822	iron-sulfur transferase activity
IJ21_RS07250	COG0719	Fe-S assembly protein
IJ21_RS07260	COG0673	inositol 2-dehydrogenase activity
IJ21_RS07280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IJ21_RS07285	COG0314	molybdopterin synthase activity
IJ21_RS07290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IJ21_RS07300	COG0737	Belongs to the 5'-nucleotidase family
IJ21_RS07305	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IJ21_RS07305	COG2199	diguanylate cyclase activity
IJ21_RS07310	COG0535	radical SAM domain protein
IJ21_RS07315	COG0628	permease
IJ21_RS07330	COG3546	catalase activity
IJ21_RS07355	COG0189	ligase activity
IJ21_RS07360	COG0189	ligase activity
IJ21_RS07365	COG0189	ligase activity
IJ21_RS07385	COG4109	DRTGG domain
IJ21_RS07405	COG0587	DNA-directed DNA polymerase activity
IJ21_RS07410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IJ21_RS07420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IJ21_RS07425	COG0825	malonyl-CoA metabolic process
IJ21_RS07435	COG0824	Thioesterase
IJ21_RS07440	COG3030	protein affecting phage T7 exclusion by the F plasmid
IJ21_RS07445	COG0628	permease
IJ21_RS07450	COG0372	Belongs to the citrate synthase family
IJ21_RS07455	COG0538	isocitrate dehydrogenase activity
IJ21_RS07460	COG0039	L-malate dehydrogenase activity
IJ21_RS07465	COG0514	ATP-dependent DNA helicase (RecQ)
IJ21_RS07480	COG1349	DNA-binding transcription factor activity
IJ21_RS07490	COG0363	glucosamine-6-phosphate deaminase activity
IJ21_RS07495	COG1304	FMN binding
IJ21_RS07500	COG1609	Transcriptional regulator
IJ21_RS07520	COG2226	methyltransferase
IJ21_RS07525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS07525	COG3453	Protein conserved in bacteria
IJ21_RS07535	COG3344	reverse transcriptase
IJ21_RS07540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IJ21_RS07545	COG5401	PFAM Sporulation and spore germination
IJ21_RS07550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IJ21_RS07555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IJ21_RS07570	COG1120	ATPase activity
IJ21_RS07670	COG1518	maintenance of DNA repeat elements
IJ21_RS07675	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IJ21_RS07705	COG0367	asparagine synthase
IJ21_RS07760	COG0544	peptidyl-prolyl cis-trans isomerase activity
IJ21_RS07765	COG0740	serine-type endopeptidase activity
IJ21_RS07770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IJ21_RS07780	COG1067	ATP-dependent peptidase activity
IJ21_RS07780	COG0470	DNA polymerase III
IJ21_RS07800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IJ21_RS07820	COG0113	porphobilinogen synthase activity
IJ21_RS07825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IJ21_RS07830	COG0564	pseudouridine synthase activity
IJ21_RS07835	COG1388	LysM domain
IJ21_RS07840	COG0525	valine-tRNA ligase activity
IJ21_RS07845	COG0285	dihydrofolate synthase activity
IJ21_RS07850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IJ21_RS07865	COG0424	maF-like protein
IJ21_RS07870	COG2003	Belongs to the UPF0758 family
IJ21_RS07875	COG1077	Cell shape determining protein MreB Mrl
IJ21_RS07890	COG0850	regulation of cytokinetic process
IJ21_RS07895	COG2894	cell division
IJ21_RS07900	COG0772	Belongs to the SEDS family
IJ21_RS07905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IJ21_RS07915	COG1994	Peptidase M50
IJ21_RS07925	COG1530	ribonuclease E activity
IJ21_RS07945	COG0492	ferredoxin-NADP+ reductase activity
IJ21_RS07950	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IJ21_RS07955	COG2868	ribosomal protein
IJ21_RS07960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IJ21_RS07970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IJ21_RS07975	COG4492	Belongs to the UPF0735 family
IJ21_RS07980	COG0460	homoserine dehydrogenase
IJ21_RS07985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IJ21_RS07990	COG0083	homoserine kinase activity
IJ21_RS07995	COG0077	Prephenate dehydratase
IJ21_RS08000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IJ21_RS08005	COG1388	LysM domain
IJ21_RS08015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IJ21_RS08020	COG0632	four-way junction helicase activity
IJ21_RS08025	COG2255	four-way junction helicase activity
IJ21_RS08030	COG2385	sporulation resulting in formation of a cellular spore
IJ21_RS08030	COG2385	sporulation resulting in formation of a cellular spore
IJ21_RS08035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IJ21_RS08040	COG0343	queuine tRNA-ribosyltransferase activity
IJ21_RS08045	COG1862	Preprotein translocase
IJ21_RS08060	COG2323	membrane
IJ21_RS08065	COG2244	polysaccharide biosynthetic process
IJ21_RS08080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IJ21_RS08085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IJ21_RS08085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IJ21_RS08090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IJ21_RS08095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IJ21_RS08100	COG1490	D-aminoacyl-tRNA deacylase activity
IJ21_RS08105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IJ21_RS08110	COG0124	histidyl-tRNA synthetase
IJ21_RS08115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IJ21_RS08120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IJ21_RS08130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IJ21_RS08135	COG1253	flavin adenine dinucleotide binding
IJ21_RS08140	COG0482	sulfurtransferase activity
IJ21_RS08145	COG1959	2 iron, 2 sulfur cluster binding
IJ21_RS08150	COG1104	cysteine desulfurase activity
IJ21_RS08165	COG0628	permease
IJ21_RS08170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IJ21_RS08175	COG4472	Bacterial protein of unknown function (DUF965)
IJ21_RS08195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IJ21_RS08200	COG0826	peptidase U32
IJ21_RS08205	COG0826	peptidase U32
IJ21_RS08210	COG0840	transmembrane signaling receptor activity
IJ21_RS08220	COG0768	penicillin binding
IJ21_RS08235	COG0129	dihydroxy-acid dehydratase activity
IJ21_RS08250	COG0346	lactoylglutathione lyase activity
IJ21_RS08265	COG1695	Transcriptional regulator
IJ21_RS08270	COG1846	Transcriptional regulator
IJ21_RS08280	COG2207	Transcriptional regulator
IJ21_RS08280	COG4753	response regulator
IJ21_RS08285	COG2972	Histidine kinase
IJ21_RS08300	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS08310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IJ21_RS08315	COG1070	Carbohydrate kinase
IJ21_RS08320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IJ21_RS08325	COG0390	transport system, permease component
IJ21_RS08330	COG0778	Nitroreductase
IJ21_RS08345	COG4120	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS08350	COG1122	ATPase activity
IJ21_RS08355	COG1609	Transcriptional regulator
IJ21_RS08400	COG0383	alpha-mannosidase activity
IJ21_RS08410	COG1940	carbohydrate kinase activity
IJ21_RS08445	COG1653	transport
IJ21_RS08450	COG4209	transmembrane transport
IJ21_RS08455	COG0395	ABC-type sugar transport system, permease component
IJ21_RS08465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IJ21_RS08480	COG2188	Transcriptional regulator
IJ21_RS08495	COG0395	ABC-type sugar transport system, permease component
IJ21_RS08500	COG0626	cystathionine gamma-synthase activity
IJ21_RS08510	COG1979	alcohol dehydrogenase
IJ21_RS08525	COG0069	glutamate synthase activity
IJ21_RS08540	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IJ21_RS08565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS08575	COG0667	Aldo Keto reductase
IJ21_RS08580	COG1956	GAF domain-containing protein
IJ21_RS08590	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS08595	COG1609	Transcriptional regulator
IJ21_RS08605	COG1175	transmembrane transport
IJ21_RS08610	COG0395	ABC-type sugar transport system, permease component
IJ21_RS08615	COG1482	cell wall glycoprotein biosynthetic process
IJ21_RS08635	COG0366	Alpha amylase catalytic
IJ21_RS08640	COG1929	Belongs to the glycerate kinase type-1 family
IJ21_RS08675	COG3177	Filamentation induced by cAMP protein fic
IJ21_RS08720	COG1396	sequence-specific DNA binding
IJ21_RS08790	COG0305	Participates in initiation and elongation during chromosome replication
IJ21_RS08870	COG0582	viral genome integration into host DNA
IJ21_RS08950	COG1388	LysM domain
IJ21_RS08950	COG3942	CHAP domain
IJ21_RS09005	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS09050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS09060	COG2207	Transcriptional regulator
IJ21_RS09075	COG2207	Transcriptional regulator
IJ21_RS09080	COG4209	transmembrane transport
IJ21_RS09085	COG0395	ABC-type sugar transport system, permease component
IJ21_RS09090	COG1653	transport
IJ21_RS09115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IJ21_RS09125	COG0714	Associated with various cellular activities
IJ21_RS09135	COG1305	Transglutaminase-like
IJ21_RS09140	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IJ21_RS09145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IJ21_RS09150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IJ21_RS09155	COG1534	Rna-binding protein
IJ21_RS09160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IJ21_RS09165	COG1713	HD superfamily hydrolase involved in NAD metabolism
IJ21_RS09170	COG0799	negative regulation of ribosome biogenesis
IJ21_RS09175	COG2996	Protein conserved in bacteria
IJ21_RS09180	COG2226	methyltransferase
IJ21_RS09195	COG0714	Associated with various cellular activities
IJ21_RS09225	COG0495	leucyl-tRNA aminoacylation
IJ21_RS09230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IJ21_RS09235	COG1555	photosystem II stabilization
IJ21_RS09235	COG1596	polysaccharide export
IJ21_RS09250	COG2333	competence protein COMEC
IJ21_RS09250	COG0658	competence protein
IJ21_RS09255	COG1595	DNA-templated transcription, initiation
IJ21_RS09265	COG1466	dna polymerase III delta subunit
IJ21_RS09270	COG0268	Binds directly to 16S ribosomal RNA
IJ21_RS09280	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS09290	COG0481	GTPase activity
IJ21_RS09295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IJ21_RS09300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IJ21_RS09300	COG0165	Argininosuccinate lyase
IJ21_RS09305	COG1420	regulation of RNA biosynthetic process
IJ21_RS09315	COG0443	Heat shock 70 kDa protein
IJ21_RS09330	COG2264	protein methyltransferase activity
IJ21_RS09335	COG1994	Peptidase M50
IJ21_RS09340	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IJ21_RS09345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IJ21_RS09355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IJ21_RS09360	COG1283	sodium-dependent phosphate transmembrane transporter activity
IJ21_RS09365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IJ21_RS09375	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IJ21_RS09380	COG1074	ATP-dependent DNA helicase activity
IJ21_RS09385	COG0420	3'-5' exonuclease activity
IJ21_RS09390	COG0419	ATPase involved in DNA repair
IJ21_RS09410	COG0537	adenosine 5'-monophosphoramidase activity
IJ21_RS09415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IJ21_RS09420	COG1610	YqeY-like protein
IJ21_RS09425	COG1030	water channel activity
IJ21_RS09430	COG4864	UPF0365 protein
IJ21_RS09450	COG1702	phosphate starvation-inducible protein PhoH
IJ21_RS09455	COG1480	7TM receptor with intracellular HD hydrolase
IJ21_RS09460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IJ21_RS09465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IJ21_RS09470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IJ21_RS09475	COG1381	Involved in DNA repair and RecF pathway recombination
IJ21_RS09480	COG0534	Mate efflux family protein
IJ21_RS09485	COG0752	glycyl-tRNA synthetase alpha subunit
IJ21_RS09490	COG0751	glycine-tRNA ligase activity
IJ21_RS09500	COG1671	Belongs to the UPF0178 family
IJ21_RS09505	COG0358	DNA primase activity
IJ21_RS09520	COG2384	SAM-dependent methyltransferase
IJ21_RS09525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IJ21_RS09555	COG0741	lytic transglycosylase activity
IJ21_RS09560	COG1104	cysteine desulfurase activity
IJ21_RS09565	COG0301	tRNA thio-modification
IJ21_RS09570	COG0861	Integral membrane protein TerC family
IJ21_RS09575	COG0861	Integral membrane protein TerC family
IJ21_RS09585	COG1217	gtp-binding protein TYPA
IJ21_RS09600	COG1316	TRANSCRIPTIONal
IJ21_RS09615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IJ21_RS09645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IJ21_RS09655	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IJ21_RS09660	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IJ21_RS09670	COG2001	Belongs to the MraZ family
IJ21_RS09675	COG0275	rRNA processing
IJ21_RS09685	COG0768	penicillin binding
IJ21_RS09690	COG0768	penicillin binding
IJ21_RS09700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IJ21_RS09705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IJ21_RS09710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IJ21_RS09715	COG0772	Belongs to the SEDS family
IJ21_RS09725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IJ21_RS09730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IJ21_RS09735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IJ21_RS09740	COG0849	cell division
IJ21_RS09745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IJ21_RS09755	COG1191	sigma factor activity
IJ21_RS09760	COG1191	sigma factor activity
IJ21_RS09765	COG1873	PFAM PRC-barrel domain
IJ21_RS09770	COG1496	oxidoreductase activity
IJ21_RS09775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IJ21_RS09780	COG1799	cell septum assembly
IJ21_RS09790	COG2302	S4 RNA-binding domain
IJ21_RS09795	COG3599	regulation of cell shape
IJ21_RS09815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IJ21_RS09820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IJ21_RS09825	COG0564	pseudouridine synthase activity
IJ21_RS09830	COG0436	Aminotransferase
IJ21_RS09840	COG0540	Belongs to the ATCase OTCase family
IJ21_RS09855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IJ21_RS09860	COG0284	orotidine-5'-phosphate decarboxylase activity
IJ21_RS09870	COG1131	(ABC) transporter
IJ21_RS09885	COG1131	(ABC) transporter
IJ21_RS09900	COG0656	L-ascorbic acid biosynthetic process
IJ21_RS09905	COG2755	lipolytic protein G-D-S-L family
IJ21_RS09905	COG0657	acetylesterase activity
IJ21_RS09915	COG1136	(ABC) transporter
IJ21_RS09920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IJ21_RS09930	COG1136	(ABC) transporter
IJ21_RS09930	COG0577	efflux transmembrane transporter activity
IJ21_RS09940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IJ21_RS09980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IJ21_RS10010	COG1234	tRNA 3'-trailer cleavage
IJ21_RS10040	COG1982	Orn Lys Arg decarboxylase major
IJ21_RS10050	COG4493	Belongs to the UPF0637 family
IJ21_RS10060	COG1070	Carbohydrate kinase
IJ21_RS10065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IJ21_RS10075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IJ21_RS10080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IJ21_RS10085	COG1832	CoA-binding protein
IJ21_RS10095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IJ21_RS10095	COG1263	PTS System
IJ21_RS10095	COG2190	(PTS) system
IJ21_RS10100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IJ21_RS10130	COG0123	including yeast histone deacetylase and acetoin utilization protein
IJ21_RS10135	COG0454	-acetyltransferase
IJ21_RS10140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IJ21_RS10145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IJ21_RS10150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IJ21_RS10160	COG2268	Band 7 protein
IJ21_RS10165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IJ21_RS10190	COG4838	Belongs to the UPF0358 family
IJ21_RS10195	COG1302	Protein conserved in bacteria
IJ21_RS10200	COG0772	Belongs to the SEDS family
IJ21_RS10210	COG1473	amidohydrolase
IJ21_RS10215	COG0517	IMP dehydrogenase activity
IJ21_RS10220	COG1525	nuclease
IJ21_RS10250	COG0697	spore germination
IJ21_RS10260	COG0613	PHP domain protein
IJ21_RS10270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IJ21_RS10275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IJ21_RS10280	COG0646	methionine synthase
IJ21_RS10280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IJ21_RS10285	COG2052	Domain of unknown function (DUF370)
IJ21_RS10290	COG0194	GDP metabolic process
IJ21_RS10295	COG1758	RNA polymerase activity
IJ21_RS10300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IJ21_RS10305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IJ21_RS10310	COG0242	peptide deformylase activity
IJ21_RS10315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IJ21_RS10320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IJ21_RS10320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IJ21_RS10325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IJ21_RS10330	COG0631	protein serine/threonine phosphatase activity
IJ21_RS10335	COG2815	serine threonine protein kinase
IJ21_RS10335	COG0515	serine threonine protein kinase
IJ21_RS10345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IJ21_RS10360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IJ21_RS10365	COG1653	transport
IJ21_RS10380	COG2972	Histidine kinase
IJ21_RS10385	COG2207	Transcriptional regulator
IJ21_RS10385	COG4753	response regulator
IJ21_RS10390	COG1302	Protein conserved in bacteria
IJ21_RS10395	COG1461	Dihydroxyacetone kinase
IJ21_RS10400	COG1307	EDD domain protein, DegV family
IJ21_RS10405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IJ21_RS10415	COG2135	peptidase activity
IJ21_RS10430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IJ21_RS10445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS10455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS10465	COG0084	hydrolase, TatD family'
IJ21_RS10470	COG0506	proline dehydrogenase activity
IJ21_RS10475	COG0742	ribosomal rna small subunit methyltransferase
IJ21_RS10480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IJ21_RS10485	COG3314	Sporulation integral membrane protein YlbJ
IJ21_RS10490	COG3480	Lon protease (S16) C-terminal proteolytic domain
IJ21_RS10495	COG1323	Belongs to the UPF0348 family
IJ21_RS10505	COG1349	DNA-binding transcription factor activity
IJ21_RS10510	COG0416	fatty acid biosynthetic process
IJ21_RS10515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IJ21_RS10520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IJ21_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS10530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IJ21_RS10535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IJ21_RS10545	COG1196	nuclear chromosome segregation
IJ21_RS10550	COG0552	protein localization to endoplasmic reticulum
IJ21_RS10555	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IJ21_RS10560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IJ21_RS10575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IJ21_RS10580	COG0336	Belongs to the RNA methyltransferase TrmD family
IJ21_RS10585	COG0071	Belongs to the small heat shock protein (HSP20) family
IJ21_RS10590	COG0335	large ribosomal subunit rRNA binding
IJ21_RS10605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IJ21_RS10615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IJ21_RS10620	COG0792	nuclease activity
IJ21_RS10635	COG0045	succinate-CoA ligase (ADP-forming) activity
IJ21_RS10640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IJ21_RS10645	COG0758	DNA mediated transformation
IJ21_RS10650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IJ21_RS10655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IJ21_RS10660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IJ21_RS10665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IJ21_RS10670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IJ21_RS10675	COG1815	bacterial-type flagellum-dependent cell motility
IJ21_RS10680	COG1558	bacterial-type flagellum-dependent cell motility
IJ21_RS10690	COG1766	The M ring may be actively involved in energy transduction
IJ21_RS10695	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IJ21_RS10705	COG1157	protein secretion by the type III secretion system
IJ21_RS10725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IJ21_RS10730	COG4786	Flagellar basal body rod
IJ21_RS10735	COG1582	Flagellar protein (FlbD)
IJ21_RS10745	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IJ21_RS10750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IJ21_RS10750	COG1776	CheC inhibitor of MCP methylation
IJ21_RS10755	COG2201	protein-glutamate methylesterase activity
IJ21_RS10760	COG3190	flagellar
IJ21_RS10765	COG1338	Plays a role in the flagellum-specific transport system
IJ21_RS10770	COG1987	bacterial-type flagellum assembly
IJ21_RS10775	COG1684	flagellar biosynthetic protein fliR
IJ21_RS10780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IJ21_RS10785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IJ21_RS10790	COG1419	protein localization to endoplasmic reticulum
IJ21_RS10795	COG0455	bacterial-type flagellum organization
IJ21_RS10800	COG2201	protein-glutamate methylesterase activity
IJ21_RS10805	COG0643	Histidine kinase
IJ21_RS10805	COG2198	Histidine kinase
IJ21_RS10810	COG0835	chemotaxis
IJ21_RS10815	COG1776	CheC inhibitor of MCP methylation
IJ21_RS10820	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IJ21_RS10830	COG1191	sigma factor activity
IJ21_RS10855	COG0052	Belongs to the universal ribosomal protein uS2 family
IJ21_RS10860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IJ21_RS10865	COG0528	UMP kinase activity
IJ21_RS10870	COG0233	cytoplasmic translational termination
IJ21_RS10875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IJ21_RS10880	COG4589	Belongs to the CDS family
IJ21_RS10885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IJ21_RS10890	COG0750	zinc metalloprotease
IJ21_RS10895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IJ21_RS10900	COG2176	DNA-directed DNA polymerase activity
IJ21_RS10905	COG0779	Required for maturation of 30S ribosomal subunits
IJ21_RS10910	COG0195	Participates in both transcription termination and antitermination
IJ21_RS10915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IJ21_RS10920	COG1358	cellular component organization or biogenesis
IJ21_RS10930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IJ21_RS10935	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IJ21_RS10940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IJ21_RS10945	COG0196	riboflavin kinase activity
IJ21_RS10950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IJ21_RS10955	COG1185	polyribonucleotide nucleotidyltransferase activity
IJ21_RS10960	COG0726	polysaccharide deacetylase
IJ21_RS10965	COG0612	Peptidase, M16
IJ21_RS10970	COG0756	dUTP diphosphatase activity
IJ21_RS10975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IJ21_RS10980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IJ21_RS10985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IJ21_RS10990	COG0527	aspartate kinase activity
IJ21_RS11000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IJ21_RS11005	COG0740	serine-type endopeptidase activity
IJ21_RS11015	COG1674	ftsk spoiiie
IJ21_RS11025	COG0612	Peptidase, M16
IJ21_RS11030	COG0612	Peptidase, M16
IJ21_RS11035	COG0300	oxidoreductase activity
IJ21_RS11050	COG1426	Protein conserved in bacteria
IJ21_RS11060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IJ21_RS11065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IJ21_RS11070	COG1058	Belongs to the CinA family
IJ21_RS11070	COG1546	Belongs to the CinA family
IJ21_RS11075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IJ21_RS11090	COG1692	metallophosphoesterase
IJ21_RS11095	COG2359	stage V sporulation protein S
IJ21_RS11105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IJ21_RS11105	COG0674	pyruvate-flavodoxin oxidoreductase activity
IJ21_RS11110	COG1013	pyruvate-flavodoxin oxidoreductase activity
IJ21_RS11115	COG4869	propanediol catabolic process
IJ21_RS11120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IJ21_RS11125	COG4550	Control of competence regulator ComK, YlbF/YmcA
IJ21_RS11130	COG1268	BioY protein
IJ21_RS11140	COG2814	Major facilitator Superfamily
IJ21_RS11155	COG5002	protein histidine kinase activity
IJ21_RS11160	COG0745	RESPONSE REGULATOR receiver
IJ21_RS11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IJ21_RS11170	COG1609	Transcriptional regulator
IJ21_RS11175	COG1653	transport
IJ21_RS11180	COG4209	transmembrane transport
IJ21_RS11185	COG0395	ABC-type sugar transport system, permease component
IJ21_RS11195	COG1609	Transcriptional regulator
IJ21_RS11200	COG3962	Belongs to the TPP enzyme family
IJ21_RS11205	COG1082	Xylose isomerase domain protein TIM barrel
IJ21_RS11210	COG0673	inositol 2-dehydrogenase activity
IJ21_RS11215	COG3718	enzyme involved in inositol metabolism
IJ21_RS11220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IJ21_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
IJ21_RS11230	COG0393	Putative heavy-metal-binding
IJ21_RS11240	COG1131	(ABC) transporter
IJ21_RS11255	COG0714	Associated with various cellular activities
IJ21_RS11280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS11285	COG2217	Heavy metal translocating P-type atpase
IJ21_RS11300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS11305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS11310	COG1120	ATPase activity
IJ21_RS11315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IJ21_RS11325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IJ21_RS11330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IJ21_RS11340	COG1643	Atp-dependent helicase
IJ21_RS11355	COG3973	AAA domain
IJ21_RS11360	COG2217	Heavy metal translocating P-type atpase
IJ21_RS11365	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IJ21_RS11380	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IJ21_RS11390	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IJ21_RS11395	COG1653	transport
IJ21_RS11400	COG1175	transmembrane transport
IJ21_RS11410	COG2972	Histidine kinase
IJ21_RS11415	COG2207	Transcriptional regulator
IJ21_RS11415	COG4753	response regulator
IJ21_RS11440	COG3069	C4-dicarboxylate transmembrane transporter activity
IJ21_RS11445	COG3973	AAA domain
IJ21_RS11450	COG2133	pyrroloquinoline quinone binding
IJ21_RS11465	COG0586	Pfam SNARE associated Golgi protein
IJ21_RS11470	COG3409	Peptidoglycan-binding domain 1 protein
IJ21_RS11470	COG3773	Cell wall hydrolase
IJ21_RS11480	COG1686	Belongs to the peptidase S11 family
IJ21_RS11485	COG1366	Belongs to the anti-sigma-factor antagonist family
IJ21_RS11490	COG2172	sigma factor antagonist activity
IJ21_RS11510	COG0697	spore germination
IJ21_RS11515	COG0019	diaminopimelate decarboxylase activity
IJ21_RS11520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IJ21_RS11525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IJ21_RS11525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IJ21_RS11530	COG0307	riboflavin synthase, alpha
IJ21_RS11535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IJ21_RS11535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IJ21_RS11540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IJ21_RS11545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IJ21_RS11550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IJ21_RS11560	COG3874	Sporulation protein YtfJ
IJ21_RS11565	COG1686	Belongs to the peptidase S11 family
IJ21_RS11570	COG2715	membrane protein required for spore maturation
IJ21_RS11575	COG0700	Nucleoside recognition
IJ21_RS11580	COG1187	pseudouridine synthase activity
IJ21_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS11590	COG1333	cytochrome c biogenesis protein
IJ21_RS11595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IJ21_RS11600	COG0745	RESPONSE REGULATOR receiver
IJ21_RS11605	COG5002	protein histidine kinase activity
IJ21_RS11610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IJ21_RS11615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS11625	COG1266	CAAX protease self-immunity
IJ21_RS11635	COG1408	metallophosphoesterase
IJ21_RS11640	COG0726	polysaccharide deacetylase
IJ21_RS11650	COG4862	establishment of competence for transformation
IJ21_RS11655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IJ21_RS11660	COG2339	peptidase activity
IJ21_RS11665	COG2959	enzyme of heme biosynthesis
IJ21_RS11680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IJ21_RS11690	COG0539	negative regulation of cytoplasmic translation
IJ21_RS11700	COG1160	GTP binding
IJ21_RS11705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IJ21_RS11745	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IJ21_RS11750	COG0776	regulation of translation
IJ21_RS11775	COG2226	methyltransferase
IJ21_RS11780	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IJ21_RS11785	COG0163	prenyltransferase activity
IJ21_RS11790	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IJ21_RS11800	COG0105	UTP biosynthetic process
IJ21_RS11805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IJ21_RS11810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IJ21_RS11815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IJ21_RS11820	COG4401	Chorismate mutase type I
IJ21_RS11830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IJ21_RS11835	COG0134	indole-3-glycerol-phosphate synthase activity
IJ21_RS11840	COG0135	phosphoribosylanthranilate isomerase activity
IJ21_RS11845	COG0133	tryptophan synthase activity
IJ21_RS11850	COG0159	tryptophan synthase activity
IJ21_RS11855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IJ21_RS11860	COG0287	Prephenate dehydrogenase
IJ21_RS11875	COG0406	alpha-ribazole phosphatase activity
IJ21_RS11885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IJ21_RS11900	COG0723	plastoquinol--plastocyanin reductase activity
IJ21_RS11905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IJ21_RS11915	COG4347	Protein of unknown function (DUF1405)
IJ21_RS11925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IJ21_RS11930	COG1694	Mazg nucleotide pyrophosphohydrolase
IJ21_RS11935	COG0457	Tetratricopeptide repeat
IJ21_RS11940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IJ21_RS11945	COG1803	Methylglyoxal synthase
IJ21_RS11950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IJ21_RS11955	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS11965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IJ21_RS11965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IJ21_RS11970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IJ21_RS11975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IJ21_RS11990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IJ21_RS11990	COG1199	ATP-dependent helicase activity
IJ21_RS11995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IJ21_RS12000	COG0402	S-adenosylhomocysteine deaminase activity
IJ21_RS12015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IJ21_RS12020	COG1250	3-hydroxyacyl-CoA dehydrogenase
IJ21_RS12025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IJ21_RS12030	COG0017	Asparaginyl-tRNA synthetase
IJ21_RS12035	COG3935	DnaD domain protein
IJ21_RS12040	COG0789	Transcriptional regulator
IJ21_RS12045	COG0235	Class ii aldolase
IJ21_RS12050	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IJ21_RS12055	COG1850	ribulose-bisphosphate carboxylase activity
IJ21_RS12065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IJ21_RS12070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IJ21_RS12075	COG0436	Aminotransferase
IJ21_RS12085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IJ21_RS12090	COG0583	DNA-binding transcription factor activity
IJ21_RS12095	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IJ21_RS12100	COG0066	3-isopropylmalate dehydratase activity
IJ21_RS12105	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS12115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IJ21_RS12125	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IJ21_RS12130	COG0745	RESPONSE REGULATOR receiver
IJ21_RS12135	COG5002	protein histidine kinase activity
IJ21_RS12145	COG0501	Belongs to the peptidase M48B family
IJ21_RS12150	COG1132	(ABC) transporter
IJ21_RS12155	COG1132	(ABC) transporter
IJ21_RS12160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IJ21_RS12170	COG1131	(ABC) transporter
IJ21_RS12175	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IJ21_RS12180	COG0187	DNA topoisomerase II activity
IJ21_RS12185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IJ21_RS12195	COG1846	Transcriptional regulator
IJ21_RS12200	COG3328	transposase activity
IJ21_RS12205	COG0564	pseudouridine synthase activity
IJ21_RS12210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IJ21_RS12210	COG0116	Belongs to the methyltransferase superfamily
IJ21_RS12215	COG0745	RESPONSE REGULATOR receiver
IJ21_RS12220	COG5002	protein histidine kinase activity
IJ21_RS12230	COG3620	sequence-specific DNA binding
IJ21_RS12245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS12250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS12255	COG4209	transmembrane transport
IJ21_RS12260	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12270	COG4753	response regulator
IJ21_RS12270	COG2207	Transcriptional regulator
IJ21_RS12275	COG2972	Histidine kinase
IJ21_RS12285	COG2169	Transcriptional regulator
IJ21_RS12295	COG0737	Belongs to the 5'-nucleotidase family
IJ21_RS12305	COG2972	Histidine kinase
IJ21_RS12310	COG4753	response regulator
IJ21_RS12310	COG2207	Transcriptional regulator
IJ21_RS12315	COG0673	inositol 2-dehydrogenase activity
IJ21_RS12320	COG1063	alcohol dehydrogenase
IJ21_RS12325	COG4209	transmembrane transport
IJ21_RS12330	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IJ21_RS12350	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS12370	COG2368	4-hydroxyphenylacetate
IJ21_RS12375	COG2368	4-hydroxyphenylacetate
IJ21_RS12385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IJ21_RS12390	COG2011	ABC-type metal ion transport system permease component
IJ21_RS12395	COG1464	Belongs to the NlpA lipoprotein family
IJ21_RS12405	COG0523	cobalamin synthesis protein
IJ21_RS12410	COG0735	belongs to the Fur family
IJ21_RS12415	COG0640	Transcriptional regulator
IJ21_RS12425	COG2249	NAD(P)H dehydrogenase (quinone) activity
IJ21_RS12440	COG1331	Highly conserved protein containing a thioredoxin domain
IJ21_RS12450	COG2226	methyltransferase
IJ21_RS12455	COG0644	oxidoreductase
IJ21_RS12465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IJ21_RS12480	COG1547	Domain of unknown function (DUF309)
IJ21_RS12485	COG0288	reversible hydration of carbon dioxide
IJ21_RS12495	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IJ21_RS12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS12505	COG1116	anion transmembrane transporter activity
IJ21_RS12510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS12515	COG4129	membrane
IJ21_RS12530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IJ21_RS12535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IJ21_RS12540	COG2136	Putative SAM-dependent methyltransferase
IJ21_RS12540	COG2521	methyltransferase
IJ21_RS12545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IJ21_RS12550	COG1923	regulation of RNA biosynthetic process
IJ21_RS12555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IJ21_RS12560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IJ21_RS12575	COG0464	growth
IJ21_RS12580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IJ21_RS12585	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IJ21_RS12590	COG0789	Transcriptional regulator
IJ21_RS12595	COG0174	glutamine synthetase
IJ21_RS12605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IJ21_RS12625	COG1011	Hydrolase
IJ21_RS12630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IJ21_RS12635	COG1410	methionine synthase
IJ21_RS12635	COG0646	methionine synthase
IJ21_RS12640	COG1234	tRNA 3'-trailer cleavage
IJ21_RS12650	COG0778	Nitroreductase
IJ21_RS12655	COG1111	helicase
IJ21_RS12655	COG1205	dead DEAH box helicase
IJ21_RS12670	COG0647	UMP catabolic process
IJ21_RS12675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IJ21_RS12680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IJ21_RS12690	COG1119	ATPase activity
IJ21_RS12695	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IJ21_RS12700	COG2972	Histidine kinase
IJ21_RS12705	COG4753	response regulator
IJ21_RS12705	COG2207	Transcriptional regulator
IJ21_RS12710	COG1653	transport
IJ21_RS12715	COG1175	transmembrane transport
IJ21_RS12720	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IJ21_RS12730	COG1653	transport
IJ21_RS12735	COG4209	transmembrane transport
IJ21_RS12740	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IJ21_RS12750	COG2207	Transcriptional regulator
IJ21_RS12755	COG1653	transport
IJ21_RS12760	COG2815	serine threonine protein kinase
IJ21_RS12760	COG0515	serine threonine protein kinase
IJ21_RS12765	COG0488	(ABC) transporter
IJ21_RS12770	COG0745	RESPONSE REGULATOR receiver
IJ21_RS12775	COG3850	Histidine kinase
IJ21_RS12775	COG5002	protein histidine kinase activity
IJ21_RS12780	COG0791	NLP P60 protein
IJ21_RS12785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IJ21_RS12785	COG3153	acetyltransferase
IJ21_RS12790	COG0456	acetyltransferase
IJ21_RS12800	COG0321	lipoyl(octanoyl) transferase activity
IJ21_RS12800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IJ21_RS12805	COG1193	negative regulation of DNA recombination
IJ21_RS12815	COG2860	membrane
IJ21_RS12820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IJ21_RS12850	COG1607	acyl-coa hydrolase
IJ21_RS12855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IJ21_RS12860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IJ21_RS12865	COG0493	'glutamate synthase
IJ21_RS12870	COG1131	(ABC) transporter
IJ21_RS12890	COG5002	protein histidine kinase activity
IJ21_RS12935	COG1175	transmembrane transport
IJ21_RS12940	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12955	COG1175	transmembrane transport
IJ21_RS12960	COG0395	ABC-type sugar transport system, permease component
IJ21_RS12965	COG0673	inositol 2-dehydrogenase activity
IJ21_RS12975	COG1609	Transcriptional regulator
IJ21_RS12990	COG3119	arylsulfatase activity
IJ21_RS13020	COG4974	Belongs to the 'phage' integrase family
IJ21_RS13030	COG2814	Major facilitator Superfamily
IJ21_RS13035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IJ21_RS13050	COG1349	DNA-binding transcription factor activity
IJ21_RS13055	COG1653	transport
IJ21_RS13060	COG1175	transmembrane transport
IJ21_RS13070	COG3842	ATPase activity
IJ21_RS13075	COG3842	ATPase activity
IJ21_RS13080	COG1063	alcohol dehydrogenase
IJ21_RS13085	COG0698	ribose 5-phosphate isomerase
IJ21_RS13090	COG2376	Dihydroxyacetone kinase
IJ21_RS13095	COG1461	Dihydroxyacetone kinase
IJ21_RS13105	COG1349	DNA-binding transcription factor activity
IJ21_RS13110	COG3394	polysaccharide catabolic process
IJ21_RS13120	COG0674	pyruvate-flavodoxin oxidoreductase activity
IJ21_RS13150	COG0363	glucosamine-6-phosphate deaminase activity
IJ21_RS13155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IJ21_RS13160	COG4821	SIS domain
IJ21_RS13165	COG0492	ferredoxin-NADP+ reductase activity
IJ21_RS13175	COG4974	Belongs to the 'phage' integrase family
IJ21_RS13180	COG2733	membrane
IJ21_RS13205	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13220	COG1175	transmembrane transport
IJ21_RS13245	COG1609	Transcriptional regulator
IJ21_RS13260	COG1175	transmembrane transport
IJ21_RS13265	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13280	COG0217	transcriptional regulatory protein
IJ21_RS13285	COG2972	Histidine kinase
IJ21_RS13290	COG3279	Response regulator of the LytR AlgR family
IJ21_RS13300	COG1175	transmembrane transport
IJ21_RS13305	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13330	COG1175	transmembrane transport
IJ21_RS13335	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13340	COG1363	Peptidase, m42
IJ21_RS13345	COG0006	proline dipeptidase activity
IJ21_RS13350	COG1012	belongs to the aldehyde dehydrogenase family
IJ21_RS13355	COG2814	Major facilitator Superfamily
IJ21_RS13360	COG0386	Belongs to the glutathione peroxidase family
IJ21_RS13370	COG1609	Transcriptional regulator
IJ21_RS13375	COG4149	molybdate abc transporter
IJ21_RS13380	COG3842	ATPase activity
IJ21_RS13400	COG0442	prolyl-tRNA aminoacylation
IJ21_RS13410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IJ21_RS13420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IJ21_RS13425	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS13430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IJ21_RS13435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IJ21_RS13440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IJ21_RS13445	COG2084	Dehydrogenase
IJ21_RS13450	COG2186	Transcriptional regulator
IJ21_RS13455	COG2721	sulfolactate sulfo-lyase activity
IJ21_RS13460	COG4209	transmembrane transport
IJ21_RS13465	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13470	COG1653	transport
IJ21_RS13475	COG2207	Transcriptional regulator
IJ21_RS13480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IJ21_RS13500	COG0588	phosphoglycerate mutase activity
IJ21_RS13500	COG0588	phosphoglycerate mutase activity
IJ21_RS13510	COG4209	transmembrane transport
IJ21_RS13515	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13520	COG1653	transport
IJ21_RS13525	COG2188	Transcriptional regulator
IJ21_RS13555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IJ21_RS13560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IJ21_RS13570	COG1454	alcohol dehydrogenase
IJ21_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
IJ21_RS13580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IJ21_RS13585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IJ21_RS13595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IJ21_RS13600	COG0746	molybdenum cofactor guanylyltransferase activity
IJ21_RS13620	COG2267	carboxylic ester hydrolase activity
IJ21_RS13650	COG1937	Protein conserved in bacteria
IJ21_RS13670	COG1846	Transcriptional regulator
IJ21_RS13675	COG0702	epimerase
IJ21_RS13685	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS13700	COG1522	sequence-specific DNA binding
IJ21_RS13705	COG1902	pentaerythritol trinitrate reductase activity
IJ21_RS13715	COG3226	Transcriptional regulator
IJ21_RS13735	COG0673	inositol 2-dehydrogenase activity
IJ21_RS13740	COG0673	inositol 2-dehydrogenase activity
IJ21_RS13745	COG1132	(ABC) transporter
IJ21_RS13750	COG1320	monovalent cation:proton antiporter activity
IJ21_RS13755	COG2212	antiporter activity
IJ21_RS13760	COG1863	multisubunit Na H antiporter MnhE subunit
IJ21_RS13765	COG0651	ATP synthesis coupled electron transport
IJ21_RS13770	COG1006	Multisubunit Na H antiporter MnhC subunit
IJ21_RS13775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IJ21_RS13775	COG2111	Na H antiporter
IJ21_RS13805	COG0477	Major facilitator Superfamily
IJ21_RS13835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IJ21_RS13845	COG2323	membrane
IJ21_RS13860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IJ21_RS13865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IJ21_RS13870	COG1780	Probably involved in ribonucleotide reductase function
IJ21_RS13875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IJ21_RS13880	COG2059	Chromate
IJ21_RS13890	COG1940	carbohydrate kinase activity
IJ21_RS13905	COG1619	proteins homologs of microcin C7 resistance protein MccF
IJ21_RS13910	COG2195	Cleaves the N-terminal amino acid of tripeptides
IJ21_RS13930	COG1595	DNA-templated transcription, initiation
IJ21_RS13940	COG1609	Transcriptional regulator
IJ21_RS13955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IJ21_RS13960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IJ21_RS13970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IJ21_RS13975	COG0395	ABC-type sugar transport system, permease component
IJ21_RS13980	COG1175	transmembrane transport
IJ21_RS13985	COG1653	transport
IJ21_RS13995	COG2070	2-Nitropropane dioxygenase
IJ21_RS14000	COG1131	(ABC) transporter
IJ21_RS14015	COG3344	reverse transcriptase
IJ21_RS14020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IJ21_RS14025	COG1321	iron dependent repressor
IJ21_RS14025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IJ21_RS14030	COG1121	(ABC) transporter
IJ21_RS14035	COG0803	Belongs to the bacterial solute-binding protein 9 family
IJ21_RS14060	COG1842	Phage shock protein A
IJ21_RS14080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IJ21_RS14105	COG0489	protein tyrosine kinase activity
IJ21_RS14115	COG1054	Belongs to the UPF0176 family
IJ21_RS14130	COG0395	ABC-type sugar transport system, permease component
IJ21_RS14135	COG1175	transmembrane transport
IJ21_RS14140	COG3842	ATPase activity
IJ21_RS14145	COG1653	transport
IJ21_RS14160	COG0490	domain, Protein
IJ21_RS14165	COG0475	glutathione-regulated potassium exporter activity
IJ21_RS14170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IJ21_RS14185	COG1252	NADH dehydrogenase
IJ21_RS14190	COG1876	peptidase activity
IJ21_RS14205	COG3011	Protein conserved in bacteria
IJ21_RS14230	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IJ21_RS14235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IJ21_RS14240	COG1653	transport
IJ21_RS14245	COG0395	ABC-type sugar transport system, permease component
IJ21_RS14250	COG4209	transmembrane transport
IJ21_RS14255	COG1653	transport
IJ21_RS14280	COG1595	DNA-templated transcription, initiation
IJ21_RS14290	COG1131	(ABC) transporter
IJ21_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS14305	COG0640	Transcriptional regulator
IJ21_RS14325	COG3209	COG3209 Rhs family protein
IJ21_RS14325	COG4104	PAAR repeat-containing protein
IJ21_RS14360	COG1725	Transcriptional regulator
IJ21_RS14365	COG0667	Aldo Keto reductase
IJ21_RS14380	COG1649	PFAM Uncharacterised BCR, COG1649
IJ21_RS14385	COG0583	DNA-binding transcription factor activity
IJ21_RS14395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IJ21_RS14410	COG2217	Heavy metal translocating P-type atpase
IJ21_RS14415	COG0628	permease
IJ21_RS14420	COG1363	Peptidase, m42
IJ21_RS14430	COG1309	transcriptional regulator
IJ21_RS14440	COG0784	Response regulator, receiver
IJ21_RS14440	COG2205	protein histidine kinase activity
IJ21_RS14440	COG5002	protein histidine kinase activity
IJ21_RS14445	COG3764	Sortase (surface protein transpeptidase)
IJ21_RS14470	COG5522	Integral membrane protein (intg_mem_TP0381)
IJ21_RS14480	COG0488	(ABC) transporter
IJ21_RS14490	COG0673	inositol 2-dehydrogenase activity
IJ21_RS14510	COG0095	Lipoate-protein ligase
IJ21_RS14555	COG0395	ABC-type sugar transport system, permease component
IJ21_RS14560	COG4209	transmembrane transport
IJ21_RS14570	COG2207	Transcriptional regulator
IJ21_RS14570	COG4753	response regulator
IJ21_RS14575	COG2972	Histidine kinase
IJ21_RS14580	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS14590	COG0673	inositol 2-dehydrogenase activity
IJ21_RS14595	COG1201	RNA secondary structure unwinding
IJ21_RS14600	COG0561	phosphatase activity
IJ21_RS14640	COG4608	Belongs to the ABC transporter superfamily
IJ21_RS14645	COG0444	Belongs to the ABC transporter superfamily
IJ21_RS14650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS14655	COG0601	transmembrane transport
IJ21_RS14660	COG0747	negative chemotaxis
IJ21_RS14665	COG3119	arylsulfatase activity
IJ21_RS14670	COG3119	arylsulfatase activity
IJ21_RS14675	COG0529	Catalyzes the synthesis of activated sulfate
IJ21_RS14680	COG0673	inositol 2-dehydrogenase activity
IJ21_RS14685	COG3119	arylsulfatase activity
IJ21_RS14695	COG0673	inositol 2-dehydrogenase activity
IJ21_RS14720	COG0018	arginyl-trna synthetase
IJ21_RS14725	COG0508	dehydrogenase complex catalyzes the overall conversion of
IJ21_RS14730	COG0567	Dehydrogenase, E1 component
IJ21_RS14745	COG2514	catechol 2,3-dioxygenase activity
IJ21_RS14755	COG2814	Major facilitator Superfamily
IJ21_RS14760	COG0740	serine-type endopeptidase activity
IJ21_RS14790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IJ21_RS14805	COG0490	domain, Protein
IJ21_RS14810	COG0475	glutathione-regulated potassium exporter activity
IJ21_RS14825	COG4974	Belongs to the 'phage' integrase family
IJ21_RS14835	COG0686	Belongs to the AlaDH PNT family
IJ21_RS14840	COG0735	belongs to the Fur family
IJ21_RS14845	COG1300	Membrane
IJ21_RS14850	COG1379	DNA repair
IJ21_RS14865	COG2195	Cleaves the N-terminal amino acid of tripeptides
IJ21_RS14870	COG0321	lipoyl(octanoyl) transferase activity
IJ21_RS14875	COG0508	dehydrogenase complex catalyzes the overall conversion of
IJ21_RS14880	COG0022	dehydrogenase e1 component
IJ21_RS14885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IJ21_RS14890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IJ21_RS14900	COG0745	RESPONSE REGULATOR receiver
IJ21_RS14905	COG0750	zinc metalloprotease
IJ21_RS14910	COG0497	DNA recombination
IJ21_RS14915	COG1438	arginine binding
IJ21_RS14930	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IJ21_RS14935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IJ21_RS14950	COG1570	exodeoxyribonuclease VII activity
IJ21_RS14960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IJ21_RS14975	COG1302	Protein conserved in bacteria
IJ21_RS14980	COG0439	Biotin carboxylase
IJ21_RS14985	COG0511	ligase activity, forming carbon-carbon bonds
IJ21_RS15025	COG3854	ATPases associated with a variety of cellular activities
IJ21_RS15035	COG1809	phosphosulfolactate synthase activity
IJ21_RS15040	COG2045	Belongs to the ComB family
IJ21_RS15045	COG2707	UPF0756 membrane protein
IJ21_RS15065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IJ21_RS15070	COG0006	proline dipeptidase activity
IJ21_RS15075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IJ21_RS15085	COG3872	metal-dependent enzyme
IJ21_RS15095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IJ21_RS15100	COG1335	isochorismatase
IJ21_RS15110	COG1321	iron dependent repressor
IJ21_RS15115	COG0785	Cytochrome C biogenesis protein
IJ21_RS15120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IJ21_RS15125	COG1121	(ABC) transporter
IJ21_RS15140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IJ21_RS15155	COG2207	Transcriptional regulator
IJ21_RS15180	COG1349	DNA-binding transcription factor activity
IJ21_RS15185	COG1070	Carbohydrate kinase
IJ21_RS15190	COG4952	isomerase
IJ21_RS15200	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS15200	COG3347	Dehydrogenase
IJ21_RS15245	COG4154	Belongs to the RbsD FucU family
IJ21_RS15260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IJ21_RS15265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IJ21_RS15275	COG3949	Membrane
IJ21_RS15290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IJ21_RS15300	COG2017	converts alpha-aldose to the beta-anomer
IJ21_RS15305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IJ21_RS15320	COG1464	Belongs to the NlpA lipoprotein family
IJ21_RS15325	COG2011	ABC-type metal ion transport system permease component
IJ21_RS15340	COG3250	beta-galactosidase activity
IJ21_RS15350	COG1175	transmembrane transport
IJ21_RS15360	COG2972	Histidine kinase
IJ21_RS15365	COG2207	Transcriptional regulator
IJ21_RS15365	COG4753	response regulator
IJ21_RS15375	COG1064	alcohol dehydrogenase
IJ21_RS15385	COG0789	Transcriptional regulator
IJ21_RS15390	COG0667	Aldo Keto reductase
IJ21_RS15395	COG1309	transcriptional regulator
IJ21_RS15400	COG3180	Ammonia monooxygenase
IJ21_RS15405	COG1846	Transcriptional regulator
IJ21_RS15405	COG0456	acetyltransferase
IJ21_RS15410	COG1937	Protein conserved in bacteria
IJ21_RS15415	COG2210	Belongs to the sulfur carrier protein TusA family
IJ21_RS15420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS15420	COG0425	Belongs to the sulfur carrier protein TusA family
IJ21_RS15425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS15425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS15430	COG0425	Belongs to the sulfur carrier protein TusA family
IJ21_RS15430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS15440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IJ21_RS15460	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS15465	COG2861	carbohydrate metabolic process
IJ21_RS15480	COG1132	(ABC) transporter
IJ21_RS15485	COG1132	(ABC) transporter
IJ21_RS15500	COG2169	Transcriptional regulator
IJ21_RS15505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IJ21_RS15525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IJ21_RS15530	COG3949	Membrane
IJ21_RS15545	COG0384	phenazine biosynthesis protein PhzF
IJ21_RS15555	COG1011	Hydrolase
IJ21_RS15565	COG1349	DNA-binding transcription factor activity
IJ21_RS15580	COG3833	ABC-type maltose transport systems, permease component
IJ21_RS15585	COG1175	transmembrane transport
IJ21_RS15590	COG2182	Extracellular solute-binding protein
IJ21_RS15595	COG1609	Transcriptional regulator
IJ21_RS15620	COG2207	Transcriptional regulator
IJ21_RS15620	COG3708	Transcriptional regulator
IJ21_RS15625	COG0247	lactate metabolic process
IJ21_RS15630	COG0277	FAD linked oxidase domain protein
IJ21_RS15635	COG2186	Transcriptional regulator
IJ21_RS15645	COG1940	carbohydrate kinase activity
IJ21_RS15650	COG2329	Antibiotic biosynthesis monooxygenase
IJ21_RS15655	COG1119	ATPase activity
IJ21_RS15670	COG1842	Phage shock protein A
IJ21_RS15685	COG0395	ABC-type sugar transport system, permease component
IJ21_RS15690	COG4209	transmembrane transport
IJ21_RS15695	COG1653	transport
IJ21_RS15730	COG0395	ABC-type sugar transport system, permease component
IJ21_RS15735	COG4209	transmembrane transport
IJ21_RS15770	COG1587	Uroporphyrinogen-III synthase
IJ21_RS15775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IJ21_RS15780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IJ21_RS15785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS15790	COG1999	signal sequence binding
IJ21_RS15795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IJ21_RS15800	COG0395	ABC-type sugar transport system, permease component
IJ21_RS15805	COG1175	transmembrane transport
IJ21_RS15810	COG1653	transport
IJ21_RS15820	COG4753	response regulator
IJ21_RS15820	COG2207	Transcriptional regulator
IJ21_RS15825	COG2972	Histidine kinase
IJ21_RS15840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IJ21_RS15850	COG3959	Transketolase, thiamine diphosphate binding domain
IJ21_RS15865	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS15870	COG1129	ABC transporter
IJ21_RS15890	COG1472	Belongs to the glycosyl hydrolase 3 family
IJ21_RS15895	COG1653	transport
IJ21_RS15900	COG0395	ABC-type sugar transport system, permease component
IJ21_RS15905	COG4209	transmembrane transport
IJ21_RS15910	COG2207	Transcriptional regulator
IJ21_RS15935	COG2226	methyltransferase
IJ21_RS15955	COG1605	Chorismate mutase
IJ21_RS15955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IJ21_RS15980	COG1414	Transcriptional regulator
IJ21_RS15995	COG0410	ABC transporter
IJ21_RS16015	COG0683	leucine binding
IJ21_RS16035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IJ21_RS16060	COG4608	Belongs to the ABC transporter superfamily
IJ21_RS16065	COG0444	Belongs to the ABC transporter superfamily
IJ21_RS16070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS16075	COG0601	transmembrane transport
IJ21_RS16085	COG0154	amidase activity
IJ21_RS16090	COG0561	phosphatase activity
IJ21_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS16100	COG1312	Catalyzes the dehydration of D-mannonate
IJ21_RS16105	COG1802	Transcriptional regulator
IJ21_RS16110	COG1509	lysine 2,3-aminomutase activity
IJ21_RS16115	COG0484	heat shock protein binding
IJ21_RS16120	COG1136	(ABC) transporter
IJ21_RS16125	COG0577	efflux transmembrane transporter activity
IJ21_RS16130	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS16140	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16150	COG1082	Xylose isomerase domain protein TIM barrel
IJ21_RS16160	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16165	COG2207	Transcriptional regulator
IJ21_RS16170	COG2972	Histidine kinase
IJ21_RS16175	COG2258	MOSC domain
IJ21_RS16180	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16185	COG4977	sequence-specific DNA binding
IJ21_RS16185	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS16195	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16210	COG3119	arylsulfatase activity
IJ21_RS16220	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IJ21_RS16260	COG4753	response regulator
IJ21_RS16260	COG2207	Transcriptional regulator
IJ21_RS16265	COG2972	Histidine kinase
IJ21_RS16275	COG0395	ABC-type sugar transport system, permease component
IJ21_RS16280	COG1175	transmembrane transport
IJ21_RS16290	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS16290	COG2207	Transcriptional regulator
IJ21_RS16295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS16300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS16305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IJ21_RS16320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS16330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IJ21_RS16335	COG0583	DNA-binding transcription factor activity
IJ21_RS16350	COG0604	alcohol dehydrogenase
IJ21_RS16355	COG2814	Major facilitator Superfamily
IJ21_RS16360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IJ21_RS16365	COG1752	Esterase of the alpha-beta hydrolase superfamily
IJ21_RS16375	COG0531	amino acid
IJ21_RS16385	COG0697	spore germination
IJ21_RS16405	COG0517	IMP dehydrogenase activity
IJ21_RS16410	COG0574	Belongs to the PEP-utilizing enzyme family
IJ21_RS16410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IJ21_RS16415	COG0697	spore germination
IJ21_RS16435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IJ21_RS16440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IJ21_RS16445	COG0686	Belongs to the AlaDH PNT family
IJ21_RS16450	COG2508	Transcriptional regulator
IJ21_RS16450	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IJ21_RS16455	COG1113	amino acid transport
IJ21_RS16485	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16495	COG0395	ABC-type sugar transport system, permease component
IJ21_RS16500	COG4209	transmembrane transport
IJ21_RS16505	COG1653	transport
IJ21_RS16510	COG2207	Transcriptional regulator
IJ21_RS16510	COG4753	response regulator
IJ21_RS16515	COG2972	Histidine kinase
IJ21_RS16525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IJ21_RS16530	COG0798	PFAM Bile acid sodium symporter
IJ21_RS16535	COG0640	Transcriptional regulator
IJ21_RS16545	COG1309	transcriptional regulator
IJ21_RS16550	COG2076	Multidrug Resistance protein
IJ21_RS16555	COG2076	Multidrug Resistance protein
IJ21_RS16560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS16565	COG4521	taurine ABC transporter
IJ21_RS16570	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IJ21_RS16575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS16580	COG1294	oxidase, subunit
IJ21_RS16585	COG1271	oxidase subunit
IJ21_RS16590	COG3275	phosphorelay sensor kinase activity
IJ21_RS16595	COG2207	Transcriptional regulator
IJ21_RS16600	COG4565	transcriptional regulatory protein
IJ21_RS16605	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16610	COG0673	inositol 2-dehydrogenase activity
IJ21_RS16620	COG1172	Belongs to the binding-protein-dependent transport system permease family
IJ21_RS16625	COG1129	ABC transporter
IJ21_RS16635	COG0596	Alpha beta hydrolase
IJ21_RS16640	COG1737	Transcriptional regulator
IJ21_RS16650	COG0395	ABC-type sugar transport system, permease component
IJ21_RS16655	COG4209	transmembrane transport
IJ21_RS16660	COG1653	transport
IJ21_RS16685	COG0598	Magnesium transport protein CorA
IJ21_RS16690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IJ21_RS16700	COG1752	Esterase of the alpha-beta hydrolase superfamily
IJ21_RS16715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IJ21_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS16725	COG2814	Major facilitator Superfamily
IJ21_RS16735	COG1012	belongs to the aldehyde dehydrogenase family
IJ21_RS16770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS16775	COG0604	alcohol dehydrogenase
IJ21_RS16775	COG3321	synthase
IJ21_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS16780	COG0318	PFAM AMP-dependent synthetase and ligase
IJ21_RS16820	COG2318	DinB family
IJ21_RS16825	COG2318	DinB family
IJ21_RS16830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IJ21_RS16830	COG0456	acetyltransferase
IJ21_RS16845	COG0640	Transcriptional regulator
IJ21_RS16860	COG0494	nUDIX hydrolase
IJ21_RS16900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IJ21_RS16910	COG3181	Tripartite tricarboxylate transporter family receptor
IJ21_RS16920	COG0500	methyltransferase
IJ21_RS16940	COG0861	Integral membrane protein TerC family
IJ21_RS16945	COG5609	conserved protein (DUF2294)
IJ21_RS16955	COG2378	regulation of single-species biofilm formation
IJ21_RS16970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IJ21_RS16975	COG0798	PFAM Bile acid sodium symporter
IJ21_RS16980	COG0640	Transcriptional regulator
IJ21_RS16985	COG0659	secondary active sulfate transmembrane transporter activity
IJ21_RS16990	COG0589	response to stress
IJ21_RS16995	COG0668	transmembrane transport
IJ21_RS17020	COG2205	protein histidine kinase activity
IJ21_RS17025	COG0745	RESPONSE REGULATOR receiver
IJ21_RS17045	COG4974	Belongs to the 'phage' integrase family
IJ21_RS17050	COG4974	Belongs to the 'phage' integrase family
IJ21_RS17100	COG4974	Belongs to the 'phage' integrase family
IJ21_RS17215	COG1192	Involved in chromosome partitioning
IJ21_RS17255	COG0739	heme binding
IJ21_RS17255	COG1196	nuclear chromosome segregation
IJ21_RS17255	COG0741	lytic transglycosylase activity
IJ21_RS17305	COG1742	UPF0060 membrane protein
IJ21_RS17310	COG0789	Transcriptional regulator
IJ21_RS17355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS17365	COG0785	Cytochrome C biogenesis protein
IJ21_RS17380	COG2132	Multicopper oxidase
IJ21_RS17400	COG5002	protein histidine kinase activity
IJ21_RS17420	COG2217	Heavy metal translocating P-type atpase
IJ21_RS17425	COG2608	mercury ion transmembrane transporter activity
IJ21_RS17435	COG2197	response regulator
IJ21_RS17440	COG4191	Histidine kinase
IJ21_RS17455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS17460	COG0785	Cytochrome C biogenesis protein
IJ21_RS17480	COG0737	Belongs to the 5'-nucleotidase family
IJ21_RS17485	COG2226	methyltransferase
IJ21_RS17490	COG2205	protein histidine kinase activity
IJ21_RS17505	COG1054	Belongs to the UPF0176 family
IJ21_RS17510	COG1937	Protein conserved in bacteria
IJ21_RS17515	COG2210	Belongs to the sulfur carrier protein TusA family
IJ21_RS17525	COG0425	Belongs to the sulfur carrier protein TusA family
IJ21_RS17530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS17530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS17535	COG2210	Belongs to the sulfur carrier protein TusA family
IJ21_RS17540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS17540	COG0425	Belongs to the sulfur carrier protein TusA family
IJ21_RS17545	COG0425	Belongs to the sulfur carrier protein TusA family
IJ21_RS17545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS17550	COG0730	response to heat
IJ21_RS17555	COG3118	belongs to the thioredoxin family
IJ21_RS17560	COG1309	transcriptional regulator
IJ21_RS17565	COG0577	efflux transmembrane transporter activity
IJ21_RS17565	COG1136	(ABC) transporter
IJ21_RS17580	COG2814	Major facilitator Superfamily
IJ21_RS17585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS17585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IJ21_RS17590	COG1104	cysteine desulfurase activity
IJ21_RS17595	COG0640	Transcriptional regulator
IJ21_RS17610	COG0346	lactoylglutathione lyase activity
IJ21_RS17615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IJ21_RS17625	COG0798	PFAM Bile acid sodium symporter
IJ21_RS17630	COG0640	Transcriptional regulator
IJ21_RS17635	COG2226	methyltransferase
IJ21_RS17640	COG1595	DNA-templated transcription, initiation
IJ21_RS17645	COG2072	flavoprotein involved in K transport
IJ21_RS17665	COG3328	transposase activity
IJ21_RS17720	COG4895	conserved protein (DUF2196)
IJ21_RS17725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IJ21_RS17725	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IJ21_RS17730	COG0561	phosphatase activity
IJ21_RS17735	COG1187	pseudouridine synthase activity
IJ21_RS17740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IJ21_RS17740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IJ21_RS17750	COG2357	RelA SpoT domain protein
IJ21_RS17755	COG0167	dihydroorotate dehydrogenase activity
IJ21_RS17770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IJ21_RS17775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IJ21_RS17780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IJ21_RS17785	COG2814	Major facilitator Superfamily
IJ21_RS17795	COG5002	protein histidine kinase activity
IJ21_RS17795	COG2176	DNA-directed DNA polymerase activity
IJ21_RS17805	COG0004	ammonium transporteR
IJ21_RS17810	COG0789	Transcriptional regulator
IJ21_RS17815	COG2738	Putative neutral zinc metallopeptidase
IJ21_RS17820	COG0583	DNA-binding transcription factor activity
IJ21_RS17825	COG0705	Rhomboid family
IJ21_RS17830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IJ21_RS17845	COG5578	integral membrane protein
IJ21_RS17850	COG0513	Belongs to the DEAD box helicase family
IJ21_RS17855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IJ21_RS17870	COG0450	alkyl hydroperoxide reductase
IJ21_RS17930	COG1164	Oligoendopeptidase f
IJ21_RS17935	COG1136	(ABC) transporter
IJ21_RS17945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IJ21_RS17950	COG1136	(ABC) transporter
IJ21_RS17960	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS17970	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IJ21_RS17975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IJ21_RS17980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IJ21_RS17990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IJ21_RS17995	COG0805	protein transport
IJ21_RS18000	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IJ21_RS18015	COG1368	sulfuric ester hydrolase activity
IJ21_RS18020	COG4844	belongs to the
IJ21_RS18045	COG1486	melibiose metabolic process
IJ21_RS18065	COG2445	Protein of unknown function DUF86
IJ21_RS18090	COG4824	toxin secretion phage lysis holin
IJ21_RS18105	COG3833	ABC-type maltose transport systems, permease component
IJ21_RS18110	COG1175	transmembrane transport
IJ21_RS18125	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18135	COG1653	transport
IJ21_RS18150	COG1132	(ABC) transporter
IJ21_RS18160	COG1132	(ABC) transporter
IJ21_RS18175	COG0673	inositol 2-dehydrogenase activity
IJ21_RS18180	COG2207	Transcriptional regulator
IJ21_RS18185	COG4209	transmembrane transport
IJ21_RS18190	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18210	COG3239	Fatty acid desaturase
IJ21_RS18225	COG4166	transmembrane transport
IJ21_RS18230	COG0601	transmembrane transport
IJ21_RS18235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS18240	COG0444	Belongs to the ABC transporter superfamily
IJ21_RS18245	COG4608	Belongs to the ABC transporter superfamily
IJ21_RS18255	COG1653	transport
IJ21_RS18260	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18280	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18295	COG3842	ATPase activity
IJ21_RS18300	COG5002	protein histidine kinase activity
IJ21_RS18310	COG3344	reverse transcriptase
IJ21_RS18315	COG1653	transport
IJ21_RS18320	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18325	COG4209	transmembrane transport
IJ21_RS18335	COG2972	Histidine kinase
IJ21_RS18340	COG2207	Transcriptional regulator
IJ21_RS18340	COG4753	response regulator
IJ21_RS18360	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18365	COG1175	transmembrane transport
IJ21_RS18380	COG2140	Oxalate decarboxylase
IJ21_RS18400	COG1309	transcriptional regulator
IJ21_RS18405	COG0010	Belongs to the arginase family
IJ21_RS18415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IJ21_RS18420	COG2819	hydrolase of the alpha beta superfamily
IJ21_RS18430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS18435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS18440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS18445	COG2207	Transcriptional regulator
IJ21_RS18445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS18460	COG0454	-acetyltransferase
IJ21_RS18460	COG0456	acetyltransferase
IJ21_RS18470	COG1404	Belongs to the peptidase S8 family
IJ21_RS18480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS18485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IJ21_RS18500	COG2205	protein histidine kinase activity
IJ21_RS18505	COG2972	Histidine kinase
IJ21_RS18510	COG4753	response regulator
IJ21_RS18510	COG2207	Transcriptional regulator
IJ21_RS18520	COG1175	transmembrane transport
IJ21_RS18525	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS18535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS18540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS18565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS18570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS18575	COG1116	anion transmembrane transporter activity
IJ21_RS18580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS18585	COG1132	(ABC) transporter
IJ21_RS18595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS18605	COG0492	ferredoxin-NADP+ reductase activity
IJ21_RS18615	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18620	COG1175	transmembrane transport
IJ21_RS18635	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18650	COG3842	ATPase activity
IJ21_RS18655	COG0667	Aldo Keto reductase
IJ21_RS18675	COG0596	Alpha beta hydrolase
IJ21_RS18680	COG0840	transmembrane signaling receptor activity
IJ21_RS18685	COG2249	NAD(P)H dehydrogenase (quinone) activity
IJ21_RS18695	COG0840	transmembrane signaling receptor activity
IJ21_RS18705	COG1309	transcriptional regulator
IJ21_RS18715	COG1132	(ABC) transporter
IJ21_RS18740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IJ21_RS18755	COG0237	dephospho-CoA kinase activity
IJ21_RS18760	COG1971	Probably functions as a manganese efflux pump
IJ21_RS18765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IJ21_RS18775	COG0628	permease
IJ21_RS18790	COG0704	Plays a role in the regulation of phosphate uptake
IJ21_RS18795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IJ21_RS18800	COG0581	inorganic phosphate transmembrane transporter activity
IJ21_RS18805	COG0573	inorganic phosphate transmembrane transporter activity
IJ21_RS18810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IJ21_RS18825	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18830	COG4209	transmembrane transport
IJ21_RS18835	COG1653	transport
IJ21_RS18845	COG3275	phosphorelay sensor kinase activity
IJ21_RS18860	COG1486	melibiose metabolic process
IJ21_RS18865	COG2169	Transcriptional regulator
IJ21_RS18875	COG2207	Transcriptional regulator
IJ21_RS18895	COG1653	transport
IJ21_RS18900	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18905	COG4209	transmembrane transport
IJ21_RS18915	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
IJ21_RS18925	COG1609	Transcriptional regulator
IJ21_RS18940	COG1653	transport
IJ21_RS18945	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18960	COG1653	transport
IJ21_RS18965	COG0395	ABC-type sugar transport system, permease component
IJ21_RS18970	COG4209	transmembrane transport
IJ21_RS18980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IJ21_RS18985	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IJ21_RS18985	COG1605	Chorismate mutase
IJ21_RS18990	COG0791	NLP P60 protein
IJ21_RS19000	COG0673	inositol 2-dehydrogenase activity
IJ21_RS19010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IJ21_RS19025	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS19030	COG0395	ABC-type sugar transport system, permease component
IJ21_RS19050	COG0395	ABC-type sugar transport system, permease component
IJ21_RS19055	COG1175	transmembrane transport
IJ21_RS19070	COG0395	ABC-type sugar transport system, permease component
IJ21_RS19085	COG3842	ATPase activity
IJ21_RS19095	COG1472	Belongs to the glycosyl hydrolase 3 family
IJ21_RS19110	COG2972	Histidine kinase
IJ21_RS19115	COG2207	Transcriptional regulator
IJ21_RS19120	COG0673	inositol 2-dehydrogenase activity
IJ21_RS19130	COG0745	RESPONSE REGULATOR receiver
IJ21_RS19135	COG5002	protein histidine kinase activity
IJ21_RS19140	COG0385	Bile acid
IJ21_RS19160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IJ21_RS19165	COG4715	Zinc finger, swim domain protein
IJ21_RS19175	COG4977	sequence-specific DNA binding
IJ21_RS19175	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS19200	COG1482	cell wall glycoprotein biosynthetic process
IJ21_RS19205	COG1175	transmembrane transport
IJ21_RS19210	COG1653	transport
IJ21_RS19215	COG0395	ABC-type sugar transport system, permease component
IJ21_RS19220	COG4977	sequence-specific DNA binding
IJ21_RS19220	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS19235	COG2151	metal-sulfur cluster biosynthetic enzyme
IJ21_RS19265	COG1063	alcohol dehydrogenase
IJ21_RS19270	COG2721	sulfolactate sulfo-lyase activity
IJ21_RS19275	COG0246	Mannitol dehydrogenase
IJ21_RS19280	COG4977	sequence-specific DNA binding
IJ21_RS19280	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS19285	COG1472	Belongs to the glycosyl hydrolase 3 family
IJ21_RS19290	COG2066	Belongs to the glutaminase family
IJ21_RS19300	COG1349	DNA-binding transcription factor activity
IJ21_RS19345	COG2197	response regulator
IJ21_RS19355	COG0431	NADPH-dependent FMN reductase
IJ21_RS19360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IJ21_RS19365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IJ21_RS19370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS19375	COG1116	anion transmembrane transporter activity
IJ21_RS19385	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS19405	COG1349	DNA-binding transcription factor activity
IJ21_RS19410	COG1063	alcohol dehydrogenase
IJ21_RS19435	COG0395	ABC-type sugar transport system, permease component
IJ21_RS19440	COG4209	transmembrane transport
IJ21_RS19475	COG1846	Transcriptional regulator
IJ21_RS19490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IJ21_RS19500	COG1086	Polysaccharide biosynthesis protein
IJ21_RS19510	COG0463	Glycosyl transferase, family 2
IJ21_RS19520	COG0351	phosphomethylpyrimidine kinase
IJ21_RS19525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IJ21_RS19530	COG2022	thiamine diphosphate biosynthetic process
IJ21_RS19535	COG0352	thiamine-phosphate diphosphorylase activity
IJ21_RS19540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IJ21_RS19545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IJ21_RS19555	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS19565	COG0688	phosphatidylethanolamine metabolic process
IJ21_RS19580	COG2207	Transcriptional regulator
IJ21_RS19600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IJ21_RS19605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IJ21_RS19610	COG1181	Belongs to the D-alanine--D-alanine ligase family
IJ21_RS19620	COG1131	(ABC) transporter
IJ21_RS19630	COG0300	oxidoreductase activity
IJ21_RS19655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IJ21_RS19660	COG0436	Aminotransferase
IJ21_RS19665	COG1393	Belongs to the ArsC family
IJ21_RS19670	COG0564	pseudouridine synthase activity
IJ21_RS19675	COG2096	Adenosyltransferase
IJ21_RS19685	COG3328	transposase activity
IJ21_RS19695	COG0436	Aminotransferase
IJ21_RS19700	COG1522	sequence-specific DNA binding
IJ21_RS19720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IJ21_RS19725	COG0477	Major facilitator Superfamily
IJ21_RS19735	COG3766	membrane
IJ21_RS19740	COG1193	negative regulation of DNA recombination
IJ21_RS19755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IJ21_RS19760	COG0072	phenylalanine-tRNA ligase activity
IJ21_RS19760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IJ21_RS19765	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IJ21_RS19770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IJ21_RS19780	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IJ21_RS19785	COG1609	Transcriptional regulator
IJ21_RS19805	COG1653	transport
IJ21_RS19810	COG4549	nuclear export factor GLE1
IJ21_RS19830	COG4585	Histidine kinase
IJ21_RS19840	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IJ21_RS19845	COG1984	allophanate hydrolase subunit 2
IJ21_RS19850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IJ21_RS19855	COG1131	(ABC) transporter
IJ21_RS19865	COG1595	DNA-templated transcription, initiation
IJ21_RS19875	COG1131	(ABC) transporter
IJ21_RS19905	COG1033	growth of symbiont in host cell
IJ21_RS19905	COG2409	Drug exporters of the RND superfamily
IJ21_RS19915	COG1556	Lactate utilization protein
IJ21_RS19920	COG1139	Iron-sulfur cluster binding protein
IJ21_RS19925	COG0247	lactate metabolic process
IJ21_RS19930	COG2186	Transcriptional regulator
IJ21_RS19945	COG0667	Aldo Keto reductase
IJ21_RS19950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IJ21_RS19955	COG3852	Histidine kinase
IJ21_RS19960	COG2172	sigma factor antagonist activity
IJ21_RS19965	COG3693	PFAM glycoside hydrolase, family 10
IJ21_RS19970	COG1191	sigma factor activity
IJ21_RS19980	COG0450	alkyl hydroperoxide reductase
IJ21_RS19985	COG0473	3-isopropylmalate dehydrogenase activity
IJ21_RS19990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IJ21_RS19995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IJ21_RS20000	COG0440	acetolactate synthase activity
IJ21_RS20005	COG0028	Belongs to the TPP enzyme family
IJ21_RS20020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IJ21_RS20025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IJ21_RS20035	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20040	COG1175	transmembrane transport
IJ21_RS20045	COG1653	transport
IJ21_RS20060	COG2207	Transcriptional regulator
IJ21_RS20060	COG4753	response regulator
IJ21_RS20065	COG3275	phosphorelay sensor kinase activity
IJ21_RS20070	COG1215	transferase activity, transferring glycosyl groups
IJ21_RS20080	COG0671	phosphoesterase, PA-phosphatase related
IJ21_RS20085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IJ21_RS20095	COG1242	4 iron, 4 sulfur cluster binding
IJ21_RS20100	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IJ21_RS20105	COG0346	lactoylglutathione lyase activity
IJ21_RS20110	COG1482	cell wall glycoprotein biosynthetic process
IJ21_RS20115	COG0789	Transcriptional regulator
IJ21_RS20125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IJ21_RS20130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IJ21_RS20135	COG1695	Transcriptional regulator
IJ21_RS20155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IJ21_RS20160	COG0640	Transcriptional regulator
IJ21_RS20165	COG0346	lactoylglutathione lyase activity
IJ21_RS20170	COG3328	transposase activity
IJ21_RS20210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IJ21_RS20215	COG3300	MHYT domain
IJ21_RS20215	COG5001	Diguanylate cyclase
IJ21_RS20220	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20225	COG1175	transmembrane transport
IJ21_RS20240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IJ21_RS20255	COG1653	transport
IJ21_RS20260	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20265	COG4209	transmembrane transport
IJ21_RS20270	COG1917	Cupin 2, conserved barrel domain protein
IJ21_RS20270	COG2207	Transcriptional regulator
IJ21_RS20275	COG1361	Conserved repeat domain
IJ21_RS20280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IJ21_RS20285	COG2971	BadF BadG BcrA BcrD
IJ21_RS20290	COG3876	Protein conserved in bacteria
IJ21_RS20305	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20310	COG1175	transmembrane transport
IJ21_RS20320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IJ21_RS20335	COG1737	Transcriptional regulator
IJ21_RS20340	COG0643	Histidine kinase
IJ21_RS20340	COG0784	Response regulator, receiver
IJ21_RS20340	COG2198	Histidine kinase
IJ21_RS20345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IJ21_RS20350	COG0745	RESPONSE REGULATOR receiver
IJ21_RS20355	COG2198	Histidine kinase
IJ21_RS20355	COG0643	Histidine kinase
IJ21_RS20360	COG2201	protein-glutamate methylesterase activity
IJ21_RS20375	COG0835	chemotaxis
IJ21_RS20380	COG0840	transmembrane signaling receptor activity
IJ21_RS20385	COG0582	viral genome integration into host DNA
IJ21_RS20390	COG0673	inositol 2-dehydrogenase activity
IJ21_RS20395	COG1653	transport
IJ21_RS20400	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20405	COG4209	transmembrane transport
IJ21_RS20410	COG4753	response regulator
IJ21_RS20410	COG2207	Transcriptional regulator
IJ21_RS20415	COG1695	Transcriptional regulator
IJ21_RS20425	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20430	COG4209	transmembrane transport
IJ21_RS20440	COG1609	Transcriptional regulator
IJ21_RS20445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS20450	COG0583	DNA-binding transcription factor activity
IJ21_RS20485	COG4208	sulfate ABC transporter
IJ21_RS20495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IJ21_RS20510	COG0024	Methionine aminopeptidase
IJ21_RS20515	COG3409	Peptidoglycan-binding domain 1 protein
IJ21_RS20515	COG0793	Belongs to the peptidase S41A family
IJ21_RS20520	COG0561	phosphatase activity
IJ21_RS20525	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IJ21_RS20530	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IJ21_RS20535	COG4208	sulfate ABC transporter
IJ21_RS20540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IJ21_RS20545	COG1739	Uncharacterized protein family UPF0029
IJ21_RS20550	COG0166	Belongs to the GPI family
IJ21_RS20560	COG3123	guanosine phosphorylase activity
IJ21_RS20570	COG0788	formyltetrahydrofolate deformylase activity
IJ21_RS20575	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IJ21_RS20590	COG1090	epimerase
IJ21_RS20655	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20660	COG4209	transmembrane transport
IJ21_RS20680	COG2972	Histidine kinase
IJ21_RS20685	COG1653	transport
IJ21_RS20700	COG0673	inositol 2-dehydrogenase activity
IJ21_RS20715	COG2207	Transcriptional regulator
IJ21_RS20715	COG4753	response regulator
IJ21_RS20715	COG4753	response regulator
IJ21_RS20715	COG2207	Transcriptional regulator
IJ21_RS20720	COG2972	Histidine kinase
IJ21_RS20725	COG0395	ABC-type sugar transport system, permease component
IJ21_RS20730	COG1175	transmembrane transport
IJ21_RS20735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IJ21_RS20740	COG0105	UTP biosynthetic process
IJ21_RS20745	COG1494	fructose-1,6-bisphosphatase
IJ21_RS20750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IJ21_RS20765	COG3093	addiction module antidote protein HigA
IJ21_RS20775	COG2346	COG2346, Truncated hemoglobins
IJ21_RS20780	COG3314	Sporulation integral membrane protein YlbJ
IJ21_RS20785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IJ21_RS20790	COG1132	(ABC) transporter
IJ21_RS20795	COG4470	Protein conserved in bacteria
IJ21_RS20800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IJ21_RS20805	COG0739	heme binding
IJ21_RS20825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IJ21_RS20830	COG0569	domain protein
IJ21_RS20840	COG3454	Phosphonate metabolism
IJ21_RS20845	COG0673	inositol 2-dehydrogenase activity
IJ21_RS20860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IJ21_RS20865	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IJ21_RS20870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IJ21_RS20890	COG2197	response regulator
IJ21_RS20895	COG4585	Histidine kinase
IJ21_RS20900	COG1842	Phage shock protein A
IJ21_RS20910	COG1842	Phage shock protein A
IJ21_RS20925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IJ21_RS20940	COG0735	belongs to the Fur family
IJ21_RS20950	COG0789	Transcriptional regulator
IJ21_RS21070	COG3858	chitin binding
IJ21_RS21075	COG0735	belongs to the Fur family
IJ21_RS21090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IJ21_RS21095	COG0154	amidase activity
IJ21_RS21100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IJ21_RS21115	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IJ21_RS21120	COG1131	(ABC) transporter
IJ21_RS21140	COG1595	DNA-templated transcription, initiation
IJ21_RS21190	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
IJ21_RS21205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IJ21_RS21210	COG2337	Toxic component of a toxin-antitoxin (TA) module
IJ21_RS21215	COG0864	Transcriptional regulator
IJ21_RS21220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IJ21_RS21225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IJ21_RS21230	COG3850	Histidine kinase
IJ21_RS21230	COG2205	protein histidine kinase activity
IJ21_RS21230	COG3437	response regulator, receiver
IJ21_RS21230	COG4999	Histidine kinase
IJ21_RS21260	COG1175	transmembrane transport
IJ21_RS21265	COG0395	ABC-type sugar transport system, permease component
IJ21_RS21280	COG0395	ABC-type sugar transport system, permease component
IJ21_RS21285	COG1175	transmembrane transport
IJ21_RS21295	COG2207	Transcriptional regulator
IJ21_RS21295	COG4753	response regulator
IJ21_RS21300	COG2972	Histidine kinase
IJ21_RS21320	COG0523	cobalamin synthesis protein
IJ21_RS21330	COG1846	Transcriptional regulator
IJ21_RS21340	COG3328	transposase activity
IJ21_RS21345	COG0459	protein refolding
IJ21_RS21350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IJ21_RS21355	COG0805	protein transport
IJ21_RS21360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IJ21_RS21370	COG0521	Mo-molybdopterin cofactor biosynthetic process
IJ21_RS21375	COG0315	cyclic pyranopterin monophosphate synthase activity
IJ21_RS21380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IJ21_RS21385	COG0488	(ABC) transporter
IJ21_RS21400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IJ21_RS21415	COG0456	acetyltransferase
IJ21_RS21420	COG1214	PFAM Peptidase M22, glycoprotease
IJ21_RS21425	COG0802	atpase or kinase
IJ21_RS21430	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IJ21_RS21435	COG0402	S-adenosylhomocysteine deaminase activity
IJ21_RS21445	COG0154	amidase activity
IJ21_RS21455	COG1335	isochorismatase
IJ21_RS21465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IJ21_RS21475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IJ21_RS21485	COG0405	Gamma-glutamyltransferase
IJ21_RS21490	COG1522	sequence-specific DNA binding
IJ21_RS21495	COG2059	Chromate
IJ21_RS21500	COG2059	Chromate
IJ21_RS21505	COG0492	ferredoxin-NADP+ reductase activity
IJ21_RS21525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IJ21_RS21530	COG1253	flavin adenine dinucleotide binding
IJ21_RS21535	COG3285	dna ligase
IJ21_RS21535	COG1793	dna ligase
IJ21_RS21550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IJ21_RS21555	COG1131	(ABC) transporter
IJ21_RS21570	COG0529	Catalyzes the synthesis of activated sulfate
IJ21_RS21575	COG1132	(ABC) transporter
IJ21_RS21605	COG3551	Protein conserved in bacteria
IJ21_RS21615	COG1316	TRANSCRIPTIONal
IJ21_RS21620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IJ21_RS21635	COG0110	maltose O-acetyltransferase activity
IJ21_RS21650	COG0438	transferase activity, transferring glycosyl groups
IJ21_RS21675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IJ21_RS21680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IJ21_RS21685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IJ21_RS21690	COG0489	protein tyrosine kinase activity
IJ21_RS21695	COG3944	biosynthesis protein
IJ21_RS21705	COG1396	sequence-specific DNA binding
IJ21_RS21710	COG0069	glutamate synthase activity
IJ21_RS21710	COG0067	glutamate synthase
IJ21_RS21710	COG0070	glutamate synthase
IJ21_RS21725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IJ21_RS21735	COG0791	NLP P60 protein
IJ21_RS21735	COG0741	lytic transglycosylase activity
IJ21_RS21740	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS21760	COG3328	transposase activity
IJ21_RS21765	COG3328	transposase activity
IJ21_RS21780	COG0395	ABC-type sugar transport system, permease component
IJ21_RS21785	COG1175	transmembrane transport
IJ21_RS21795	COG2188	Transcriptional regulator
IJ21_RS21840	COG1388	LysM domain
IJ21_RS21840	COG4641	Protein conserved in bacteria
IJ21_RS21845	COG1216	Glycosyl transferase, family 2
IJ21_RS21850	COG1216	Glycosyl transferase, family 2
IJ21_RS21900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IJ21_RS21915	COG0488	(ABC) transporter
IJ21_RS21920	COG0673	inositol 2-dehydrogenase activity
IJ21_RS21925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IJ21_RS21930	COG1413	lyase activity
IJ21_RS21940	COG0800	Aldolase
IJ21_RS21945	COG1194	a g-specific adenine glycosylase
IJ21_RS21955	COG0736	holo-[acyl-carrier-protein] synthase activity
IJ21_RS21960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IJ21_RS21980	COG5002	protein histidine kinase activity
IJ21_RS21985	COG2267	carboxylic ester hydrolase activity
IJ21_RS21990	COG2081	HI0933 family
IJ21_RS22005	COG1131	(ABC) transporter
IJ21_RS22010	COG0667	Aldo Keto reductase
IJ21_RS22015	COG1070	Carbohydrate kinase
IJ21_RS22020	COG2115	Belongs to the xylose isomerase family
IJ21_RS22030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IJ21_RS22035	COG2814	Major facilitator Superfamily
IJ21_RS22040	COG1876	peptidase activity
IJ21_RS22050	COG2223	nitrite transmembrane transporter activity
IJ21_RS22055	COG2706	6-phosphogluconolactonase activity
IJ21_RS22070	COG0463	Glycosyl transferase, family 2
IJ21_RS22085	COG1178	ABC-type Fe3 transport system permease component
IJ21_RS22090	COG1840	ABC-type Fe3 transport system, periplasmic component
IJ21_RS22100	COG1668	transmembrane transport
IJ21_RS22105	COG4152	abc transporter atp-binding protein
IJ21_RS22110	COG1131	(ABC) transporter
IJ21_RS22130	COG3336	cytochrome c oxidase
IJ21_RS22150	COG2010	Cytochrome c
IJ21_RS22150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IJ21_RS22160	COG0667	Aldo Keto reductase
IJ21_RS22165	COG1733	regulation of RNA biosynthetic process
IJ21_RS22170	COG0791	NLP P60 protein
IJ21_RS22175	COG3344	reverse transcriptase
IJ21_RS22185	COG1227	inorganic diphosphatase activity
IJ21_RS22190	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IJ21_RS22200	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22210	COG1653	transport
IJ21_RS22215	COG2207	Transcriptional regulator
IJ21_RS22215	COG4753	response regulator
IJ21_RS22225	COG2972	Histidine kinase
IJ21_RS22230	COG1073	alpha beta
IJ21_RS22260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IJ21_RS22270	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IJ21_RS22295	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS22300	COG0457	Tetratricopeptide repeat
IJ21_RS22315	COG1653	transport
IJ21_RS22320	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22325	COG1175	transmembrane transport
IJ21_RS22330	COG4948	Mandelate Racemase Muconate Lactonizing
IJ21_RS22335	COG1802	Transcriptional regulator
IJ21_RS22340	COG1346	cytolysis
IJ21_RS22355	COG1396	sequence-specific DNA binding
IJ21_RS22360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IJ21_RS22370	COG2972	Histidine kinase
IJ21_RS22375	COG4753	response regulator
IJ21_RS22375	COG2207	Transcriptional regulator
IJ21_RS22385	COG1175	transmembrane transport
IJ21_RS22390	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22400	COG0596	Alpha beta hydrolase
IJ21_RS22410	COG2002	toxin-antitoxin pair type II binding
IJ21_RS22415	COG0765	amino acid transport
IJ21_RS22420	COG1126	abc transporter atp-binding protein
IJ21_RS22435	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22440	COG4209	transmembrane transport
IJ21_RS22445	COG1653	transport
IJ21_RS22450	COG3275	phosphorelay sensor kinase activity
IJ21_RS22455	COG4753	response regulator
IJ21_RS22455	COG2207	Transcriptional regulator
IJ21_RS22460	COG0753	catalase activity
IJ21_RS22465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IJ21_RS22470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IJ21_RS22480	COG1063	alcohol dehydrogenase
IJ21_RS22485	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IJ21_RS22495	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22510	COG1609	Transcriptional regulator
IJ21_RS22530	COG3693	PFAM glycoside hydrolase, family 10
IJ21_RS22570	COG2972	Histidine kinase
IJ21_RS22580	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22585	COG4209	transmembrane transport
IJ21_RS22590	COG2309	aminopeptidase activity
IJ21_RS22595	COG1285	pathogenesis
IJ21_RS22610	COG2211	Major facilitator Superfamily
IJ21_RS22615	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS22620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IJ21_RS22625	COG4753	response regulator
IJ21_RS22625	COG2207	Transcriptional regulator
IJ21_RS22630	COG2972	Histidine kinase
IJ21_RS22645	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22650	COG4209	transmembrane transport
IJ21_RS22660	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS22670	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS22680	COG1175	transmembrane transport
IJ21_RS22690	COG1285	pathogenesis
IJ21_RS22695	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IJ21_RS22700	COG0647	UMP catabolic process
IJ21_RS22720	COG3328	transposase activity
IJ21_RS22725	COG2819	hydrolase of the alpha beta superfamily
IJ21_RS22730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS22735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS22735	COG2207	Transcriptional regulator
IJ21_RS22745	COG0604	alcohol dehydrogenase
IJ21_RS22750	COG0318	PFAM AMP-dependent synthetase and ligase
IJ21_RS22755	COG2050	protein possibly involved in aromatic compounds catabolism
IJ21_RS22785	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS22790	COG5001	Diguanylate cyclase
IJ21_RS22825	COG0395	ABC-type sugar transport system, permease component
IJ21_RS22830	COG4209	transmembrane transport
IJ21_RS22840	COG2197	response regulator
IJ21_RS22845	COG2972	Histidine kinase
IJ21_RS22855	COG0574	Belongs to the PEP-utilizing enzyme family
IJ21_RS22855	COG3848	Pyruvate phosphate dikinase
IJ21_RS22890	COG4264	IucA IucC family
IJ21_RS22895	COG0019	diaminopimelate decarboxylase activity
IJ21_RS22905	COG4264	IucA IucC family
IJ21_RS22910	COG4264	IucA IucC family
IJ21_RS22935	COG1120	ATPase activity
IJ21_RS22940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS22945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS22950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS22975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IJ21_RS22980	COG1597	lipid kinase activity
IJ21_RS22990	COG4496	protein, YerC YecD
IJ21_RS23000	COG0306	phosphate transporter
IJ21_RS23005	COG1392	Phosphate transport regulator
IJ21_RS23010	COG1470	cell adhesion involved in biofilm formation
IJ21_RS23020	COG5002	protein histidine kinase activity
IJ21_RS23025	COG0745	RESPONSE REGULATOR receiver
IJ21_RS23040	COG0151	Belongs to the GarS family
IJ21_RS23045	COG0138	bifunctional purine biosynthesis protein purh
IJ21_RS23050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IJ21_RS23055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IJ21_RS23060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IJ21_RS23065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IJ21_RS23075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IJ21_RS23080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IJ21_RS23085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IJ21_RS23090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IJ21_RS23095	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IJ21_RS23100	COG2252	PERMEase
IJ21_RS23105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IJ21_RS23105	COG0519	Catalyzes the synthesis of GMP from XMP
IJ21_RS23120	COG0714	Associated with various cellular activities
IJ21_RS23145	COG0194	GDP metabolic process
IJ21_RS23150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IJ21_RS23155	COG2207	Transcriptional regulator
IJ21_RS23160	COG4209	transmembrane transport
IJ21_RS23165	COG0395	ABC-type sugar transport system, permease component
IJ21_RS23185	COG4555	ABC transporter
IJ21_RS23195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IJ21_RS23205	COG1132	(ABC) transporter
IJ21_RS23215	COG1309	transcriptional regulator
IJ21_RS23220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IJ21_RS23225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IJ21_RS23230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IJ21_RS23235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IJ21_RS23235	COG1918	ferrous iron import across plasma membrane
IJ21_RS23240	COG0483	inositol monophosphate 1-phosphatase activity
IJ21_RS23245	COG0730	response to heat
IJ21_RS23270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IJ21_RS23280	COG1414	Transcriptional regulator
IJ21_RS23290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IJ21_RS23295	COG0302	gtp cyclohydrolase
IJ21_RS23305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IJ21_RS23310	COG0328	RNA-DNA hybrid ribonuclease activity
IJ21_RS23315	COG0681	Belongs to the peptidase S26 family
IJ21_RS23330	COG0431	NADPH-dependent FMN reductase
IJ21_RS23335	COG1069	ribulokinase activity
IJ21_RS23350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IJ21_RS23360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IJ21_RS23365	COG2246	polysaccharide biosynthetic process
IJ21_RS23370	COG0432	Pfam Uncharacterised protein family UPF0047
IJ21_RS23380	COG0783	Belongs to the Dps family
IJ21_RS23385	COG0179	Fumarylacetoacetate (FAA) hydrolase
IJ21_RS23390	COG0488	(ABC) transporter
IJ21_RS23400	COG0402	S-adenosylhomocysteine deaminase activity
IJ21_RS23410	COG0800	Aldolase
IJ21_RS23430	COG0318	PFAM AMP-dependent synthetase and ligase
IJ21_RS23435	COG1960	acyl-CoA dehydrogenase activity
IJ21_RS23440	COG0183	Belongs to the thiolase family
IJ21_RS23445	COG1024	Enoyl-CoA hydratase
IJ21_RS23445	COG1250	3-hydroxyacyl-CoA dehydrogenase
IJ21_RS23450	COG0247	lactate metabolic process
IJ21_RS23450	COG2181	nitrate reductase activity
IJ21_RS23455	COG2086	electron transfer activity
IJ21_RS23460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IJ21_RS23490	COG2207	Transcriptional regulator
IJ21_RS23500	COG0395	ABC-type sugar transport system, permease component
IJ21_RS23505	COG4209	transmembrane transport
IJ21_RS23510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IJ21_RS23525	COG1857	crispr-associated protein
IJ21_RS23540	COG1203	CRISPR-associated helicase, Cas3
IJ21_RS23550	COG2378	regulation of single-species biofilm formation
IJ21_RS23570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IJ21_RS23585	COG1253	flavin adenine dinucleotide binding
IJ21_RS23600	COG0546	phosphoglycolate phosphatase activity
IJ21_RS23605	COG4608	Belongs to the ABC transporter superfamily
IJ21_RS23615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IJ21_RS23620	COG0601	transmembrane transport
IJ21_RS23625	COG0747	negative chemotaxis
IJ21_RS23630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IJ21_RS23640	COG0398	Pfam SNARE associated Golgi protein
IJ21_RS23650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IJ21_RS23665	COG1175	transmembrane transport
IJ21_RS23670	COG0395	ABC-type sugar transport system, permease component
IJ21_RS23685	COG4129	membrane
IJ21_RS23690	COG4191	Histidine kinase
IJ21_RS23695	COG1970	mechanosensitive ion channel activity
IJ21_RS23705	COG1696	Membrane protein involved in D-alanine export
IJ21_RS23720	COG1609	Transcriptional regulator
IJ21_RS23730	COG3534	alpha-L-arabinofuranosidase
IJ21_RS23735	COG0515	serine threonine protein kinase
IJ21_RS23745	COG0745	RESPONSE REGULATOR receiver
IJ21_RS23755	COG1028	Short-chain dehydrogenase reductase Sdr
IJ21_RS23760	COG1132	(ABC) transporter
IJ21_RS23765	COG1132	(ABC) transporter
IJ21_RS23770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IJ21_RS23775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IJ21_RS23780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS23785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IJ21_RS23790	COG1120	ATPase activity
IJ21_RS23795	COG1368	sulfuric ester hydrolase activity
IJ21_RS23800	COG2357	RelA SpoT domain protein
IJ21_RS23810	COG0477	Major facilitator Superfamily
IJ21_RS23815	COG1846	Transcriptional regulator
IJ21_RS23820	COG1609	Transcriptional regulator
IJ21_RS23830	COG0038	chloride channel
IJ21_RS23835	COG0667	Aldo Keto reductase
IJ21_RS23840	COG3458	cephalosporin-C deacetylase activity
IJ21_RS23845	COG0584	glycerophosphoryl diester phosphodiesterase
IJ21_RS23860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IJ21_RS23865	COG0395	ABC-type sugar transport system, permease component
IJ21_RS23870	COG1175	transmembrane transport
IJ21_RS23875	COG1653	transport
IJ21_RS23885	COG3275	phosphorelay sensor kinase activity
IJ21_RS23890	COG2207	Transcriptional regulator
IJ21_RS23890	COG4753	response regulator
IJ21_RS23895	COG1611	Belongs to the LOG family
IJ21_RS23935	COG0789	Transcriptional regulator
IJ21_RS23950	COG0860	N-Acetylmuramoyl-L-alanine amidase
IJ21_RS23955	COG0656	L-ascorbic acid biosynthetic process
IJ21_RS23965	COG1131	(ABC) transporter
IJ21_RS23985	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IJ21_RS23985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IJ21_RS23995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IJ21_RS24000	COG1063	alcohol dehydrogenase
IJ21_RS24015	COG1850	ribulose-bisphosphate carboxylase activity
IJ21_RS24030	COG5285	phytanoyl-CoA dioxygenase
IJ21_RS24040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IJ21_RS24045	COG4821	SIS domain
IJ21_RS24055	COG1735	metal-dependent hydrolase with the TIM-barrel fold
IJ21_RS24075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system