locus-tag	class	description
H70737_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H70737_RS00010	COG0592	DNA-directed DNA polymerase activity
H70737_RS00015	COG2501	S4 domain
H70737_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H70737_RS00030	COG0187	DNA topoisomerase II activity
H70737_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H70737_RS00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H70737_RS00075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H70737_RS00080	COG0444	Belongs to the ABC transporter superfamily
H70737_RS00085	COG4608	Belongs to the ABC transporter superfamily
H70737_RS00095	COG1228	amidohydrolase
H70737_RS00130	COG1982	Orn Lys Arg decarboxylase major
H70737_RS00135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H70737_RS00140	COG3870	Protein conserved in bacteria
H70737_RS00145	COG1728	Protein conserved in bacteria
H70737_RS00150	COG0470	DNA polymerase III
H70737_RS00155	COG1774	PSP1 C-terminal conserved region
H70737_RS00160	COG4467	Involved in initiation control of chromosome replication
H70737_RS00165	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H70737_RS00170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H70737_RS00175	COG2002	toxin-antitoxin pair type II binding
H70737_RS00180	COG1078	dGTPase activity
H70737_RS00185	COG0084	hydrolase, TatD family'
H70737_RS00190	COG3583	domain protein
H70737_RS00190	COG3584	3D domain protein
H70737_RS00195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H70737_RS00200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H70737_RS00210	COG4466	Protein conserved in bacteria
H70737_RS00225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H70737_RS00230	COG2088	sporulation resulting in formation of a cellular spore
H70737_RS00240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H70737_RS00245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H70737_RS00265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H70737_RS00270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H70737_RS00275	COG2002	toxin-antitoxin pair type II binding
H70737_RS00280	COG2244	polysaccharide biosynthetic process
H70737_RS00285	COG3956	TIGRFAM MazG family protein
H70737_RS00295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H70737_RS00315	COG1098	S1 RNA binding domain
H70737_RS00320	COG2208	phosphoserine phosphatase activity
H70737_RS00325	COG2304	oxidoreductase activity
H70737_RS00330	COG0515	serine threonine protein kinase
H70737_RS00335	COG0037	tRNA processing
H70737_RS00345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H70737_RS00350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H70737_RS00355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H70737_RS00360	COG0157	Belongs to the NadC ModD family
H70737_RS00370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H70737_RS00375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H70737_RS00380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H70737_RS00385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H70737_RS00390	COG0512	Glutamine amidotransferase of anthranilate synthase
H70737_RS00395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H70737_RS00400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H70737_RS00405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H70737_RS00410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H70737_RS00415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H70737_RS00445	COG0517	IMP dehydrogenase activity
H70737_RS00445	COG0516	GMP reductase activity
H70737_RS00450	COG1686	Belongs to the peptidase S11 family
H70737_RS00465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H70737_RS00530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS00535	COG0590	tRNA wobble adenosine to inosine editing
H70737_RS00540	COG5002	protein histidine kinase activity
H70737_RS00545	COG1187	pseudouridine synthase activity
H70737_RS00550	COG1360	Flagellar Motor Protein
H70737_RS00555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H70737_RS00565	COG2154	pterin-4-alpha-carbinolamine dehydratase
H70737_RS00570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H70737_RS00570	COG2010	Cytochrome c
H70737_RS00580	COG0791	NLP P60 protein
H70737_RS00610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H70737_RS00625	COG0018	arginyl-trna synthetase
H70737_RS00635	COG3343	RNA polymerase activity
H70737_RS00640	COG0504	CTP synthase activity
H70737_RS00645	COG2204	response regulator
H70737_RS00655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H70737_RS00660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H70737_RS00670	COG0254	rRNA binding
H70737_RS00675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H70737_RS00680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H70737_RS00685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H70737_RS00765	COG2508	Transcriptional regulator
H70737_RS00770	COG3842	ATPase activity
H70737_RS00775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H70737_RS00780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H70737_RS00785	COG0546	phosphoglycolate phosphatase activity
H70737_RS00790	COG0110	maltose O-acetyltransferase activity
H70737_RS00805	COG1070	Carbohydrate kinase
H70737_RS00810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H70737_RS00815	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H70737_RS00820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H70737_RS00825	COG0131	Imidazoleglycerol-phosphate dehydratase
H70737_RS00830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H70737_RS00835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H70737_RS00840	COG0107	imidazoleglycerol-phosphate synthase activity
H70737_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
H70737_RS00845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H70737_RS00850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H70737_RS00855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H70737_RS00865	COG0492	ferredoxin-NADP+ reductase activity
H70737_RS00875	COG1904	glucuronate isomerase
H70737_RS00880	COG1609	Transcriptional regulator
H70737_RS00885	COG0246	Mannitol dehydrogenase
H70737_RS00890	COG2721	sulfolactate sulfo-lyase activity
H70737_RS00905	COG1940	carbohydrate kinase activity
H70737_RS00910	COG1660	Displays ATPase and GTPase activities
H70737_RS00915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H70737_RS00920	COG1481	regulation of sporulation
H70737_RS00925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H70737_RS00945	COG0740	serine-type endopeptidase activity
H70737_RS00970	COG0126	phosphoglycerate kinase activity
H70737_RS00975	COG0149	triose-phosphate isomerase activity
H70737_RS00980	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H70737_RS00985	COG0148	phosphopyruvate hydratase activity
H70737_RS00990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H70737_RS00995	COG0557	exoribonuclease II activity
H70737_RS01000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H70737_RS01010	COG0778	Nitroreductase
H70737_RS01020	COG2081	HI0933 family
H70737_RS01025	COG2081	HI0933 family
H70737_RS01030	COG0604	alcohol dehydrogenase
H70737_RS01040	COG0668	transmembrane transport
H70737_RS01055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H70737_RS01065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H70737_RS01065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS01075	COG0477	Major facilitator Superfamily
H70737_RS01110	COG0402	S-adenosylhomocysteine deaminase activity
H70737_RS01120	COG1132	(ABC) transporter
H70737_RS01130	COG2211	Major facilitator Superfamily
H70737_RS01135	COG3394	polysaccharide catabolic process
H70737_RS01150	COG0737	Belongs to the 5'-nucleotidase family
H70737_RS01160	COG0534	Mate efflux family protein
H70737_RS01165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H70737_RS01170	COG2205	protein histidine kinase activity
H70737_RS01175	COG0745	RESPONSE REGULATOR receiver
H70737_RS01185	COG0697	spore germination
H70737_RS01190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS01200	COG1486	melibiose metabolic process
H70737_RS01220	COG0395	ABC-type sugar transport system, permease component
H70737_RS01225	COG1175	transmembrane transport
H70737_RS01230	COG0189	ligase activity
H70737_RS01275	COG0531	amino acid
H70737_RS01285	COG0697	spore germination
H70737_RS01290	COG0572	uridine kinase
H70737_RS01295	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H70737_RS01325	COG0686	Belongs to the AlaDH PNT family
H70737_RS01345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H70737_RS01355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H70737_RS01360	COG4715	Zinc finger, swim domain protein
H70737_RS01365	COG0071	Belongs to the small heat shock protein (HSP20) family
H70737_RS01370	COG0484	heat shock protein binding
H70737_RS01385	COG0463	Glycosyl transferase, family 2
H70737_RS01395	COG0601	transmembrane transport
H70737_RS01400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H70737_RS01405	COG0444	Belongs to the ABC transporter superfamily
H70737_RS01410	COG4608	Belongs to the ABC transporter superfamily
H70737_RS01425	COG1309	transcriptional regulator
H70737_RS01435	COG2076	Multidrug Resistance protein
H70737_RS01450	COG0395	ABC-type sugar transport system, permease component
H70737_RS01455	COG1175	transmembrane transport
H70737_RS01460	COG1510	regulation of RNA biosynthetic process
H70737_RS01470	COG0628	permease
H70737_RS01480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H70737_RS01500	COG0803	Belongs to the bacterial solute-binding protein 9 family
H70737_RS01505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H70737_RS01510	COG1121	(ABC) transporter
H70737_RS01530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H70737_RS01535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS01545	COG1177	transmembrane transport
H70737_RS01555	COG3842	ATPase activity
H70737_RS01575	COG3655	Transcriptional regulator
H70737_RS01580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H70737_RS01585	COG0210	DNA helicase
H70737_RS01600	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H70737_RS01600	COG0662	Cupin 2, conserved barrel domain protein
H70737_RS01605	COG2972	Histidine kinase
H70737_RS01610	COG2204	response regulator
H70737_RS01620	COG4209	transmembrane transport
H70737_RS01625	COG0395	ABC-type sugar transport system, permease component
H70737_RS01635	COG0561	phosphatase activity
H70737_RS01640	COG2733	membrane
H70737_RS01645	COG0438	transferase activity, transferring glycosyl groups
H70737_RS01660	COG3850	Histidine kinase
H70737_RS01660	COG3437	response regulator, receiver
H70737_RS01660	COG2205	protein histidine kinase activity
H70737_RS01660	COG4999	Histidine kinase
H70737_RS01670	COG1523	belongs to the glycosyl hydrolase 13 family
H70737_RS01675	COG0493	'glutamate synthase
H70737_RS01680	COG0622	Phosphoesterase
H70737_RS01685	COG2957	Belongs to the agmatine deiminase family
H70737_RS01700	COG2310	stress, protein
H70737_RS01705	COG2310	stress, protein
H70737_RS01710	COG2310	stress, protein
H70737_RS01715	COG2310	stress, protein
H70737_RS01720	COG0861	Integral membrane protein TerC family
H70737_RS01735	COG1358	cellular component organization or biogenesis
H70737_RS01760	COG2116	formate transmembrane transporter activity
H70737_RS01765	COG5002	protein histidine kinase activity
H70737_RS01795	COG3275	phosphorelay sensor kinase activity
H70737_RS01800	COG3279	Response regulator of the LytR AlgR family
H70737_RS01805	COG2223	nitrite transmembrane transporter activity
H70737_RS01830	COG0508	dehydrogenase complex catalyzes the overall conversion of
H70737_RS01835	COG0567	Dehydrogenase, E1 component
H70737_RS01840	COG1396	sequence-specific DNA binding
H70737_RS01850	COG0681	Belongs to the peptidase S26 family
H70737_RS01860	COG4989	oxidoreductase activity
H70737_RS01870	COG2814	Major facilitator Superfamily
H70737_RS01885	COG2217	Heavy metal translocating P-type atpase
H70737_RS01890	COG0778	Nitroreductase
H70737_RS01895	COG1131	(ABC) transporter
H70737_RS01900	COG0842	Transport permease protein
H70737_RS01905	COG4585	Histidine kinase
H70737_RS01910	COG2197	response regulator
H70737_RS01915	COG0588	phosphoglycerate mutase activity
H70737_RS01920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H70737_RS01925	COG0583	DNA-binding transcription factor activity
H70737_RS01930	COG1942	4-Oxalocrotonate Tautomerase
H70737_RS01945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS01945	COG2207	Transcriptional regulator
H70737_RS01955	COG1132	(ABC) transporter
H70737_RS01965	COG1309	transcriptional regulator
H70737_RS01970	COG2814	Major facilitator Superfamily
H70737_RS01975	COG0583	DNA-binding transcription factor activity
H70737_RS01980	COG4122	O-methyltransferase activity
H70737_RS01985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS01990	COG0577	efflux transmembrane transporter activity
H70737_RS01995	COG1136	(ABC) transporter
H70737_RS02000	COG2205	protein histidine kinase activity
H70737_RS02005	COG0745	RESPONSE REGULATOR receiver
H70737_RS02015	COG2814	Major facilitator Superfamily
H70737_RS02040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H70737_RS02045	COG1757	Na H antiporter
H70737_RS02050	COG0251	oxidation-reduction process
H70737_RS02055	COG1053	succinate dehydrogenase
H70737_RS02075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H70737_RS02085	COG0738	Major facilitator superfamily
H70737_RS02090	COG3871	stress protein (general stress protein 26)
H70737_RS02120	COG0640	Transcriptional regulator
H70737_RS02130	COG2217	Heavy metal translocating P-type atpase
H70737_RS02140	COG4846	Membrane protein involved in cytochrome C biogenesis
H70737_RS02145	COG2261	transglycosylase associated protein
H70737_RS02150	COG2706	6-phosphogluconolactonase activity
H70737_RS02165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H70737_RS02170	COG4208	sulfate ABC transporter
H70737_RS02185	COG2207	Transcriptional regulator
H70737_RS02190	COG4209	transmembrane transport
H70737_RS02195	COG0395	ABC-type sugar transport system, permease component
H70737_RS02200	COG1653	transport
H70737_RS02225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H70737_RS02225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H70737_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS02245	COG1760	l-serine dehydratase
H70737_RS02250	COG1760	l-serine dehydratase
H70737_RS02260	COG4895	conserved protein (DUF2196)
H70737_RS02290	COG4209	transmembrane transport
H70737_RS02295	COG0395	ABC-type sugar transport system, permease component
H70737_RS02310	COG2207	Transcriptional regulator
H70737_RS02310	COG4753	response regulator
H70737_RS02315	COG2746	aminoglycoside 3-N-acetyltransferase activity
H70737_RS02320	COG0406	alpha-ribazole phosphatase activity
H70737_RS02335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H70737_RS02340	COG0431	NADPH-dependent FMN reductase
H70737_RS02345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H70737_RS02350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H70737_RS02355	COG0602	queuosine metabolic process
H70737_RS02365	COG0011	TIGRFAM Protein of
H70737_RS02385	COG2249	NAD(P)H dehydrogenase (quinone) activity
H70737_RS02390	COG1733	regulation of RNA biosynthetic process
H70737_RS02440	COG1122	ATPase activity
H70737_RS02450	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H70737_RS02455	COG0826	peptidase U32
H70737_RS02460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H70737_RS02465	COG0109	protoheme IX farnesyltransferase activity
H70737_RS02480	COG1252	NADH dehydrogenase
H70737_RS02490	COG3237	CsbD-like
H70737_RS02495	COG3850	Histidine kinase
H70737_RS02495	COG4999	Histidine kinase
H70737_RS02495	COG3437	response regulator, receiver
H70737_RS02495	COG2205	protein histidine kinase activity
H70737_RS02510	COG0251	oxidation-reduction process
H70737_RS02520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H70737_RS02530	COG2357	RelA SpoT domain protein
H70737_RS02540	COG1378	Sugar-specific transcriptional regulator TrmB
H70737_RS02550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H70737_RS02575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H70737_RS02575	COG2010	Cytochrome c
H70737_RS02590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H70737_RS02595	COG3336	cytochrome c oxidase
H70737_RS02615	COG1122	ATPase activity
H70737_RS02620	COG4152	abc transporter atp-binding protein
H70737_RS02625	COG1668	transmembrane transport
H70737_RS02655	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H70737_RS02670	COG2205	protein histidine kinase activity
H70737_RS02680	COG3118	belongs to the thioredoxin family
H70737_RS02685	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS02695	COG0789	Transcriptional regulator
H70737_RS02700	COG3118	belongs to the thioredoxin family
H70737_RS02705	COG1595	DNA-templated transcription, initiation
H70737_RS02710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H70737_RS02715	COG0697	spore germination
H70737_RS02720	COG0531	amino acid
H70737_RS02735	COG0095	Lipoate-protein ligase
H70737_RS02740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H70737_RS02745	COG1846	Transcriptional regulator
H70737_RS02750	COG0778	Nitroreductase
H70737_RS02760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H70737_RS02775	COG0659	secondary active sulfate transmembrane transporter activity
H70737_RS02790	COG0697	spore germination
H70737_RS02815	COG2329	Antibiotic biosynthesis monooxygenase
H70737_RS02830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H70737_RS02835	COG0463	Glycosyl transferase, family 2
H70737_RS02840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H70737_RS02855	COG5002	protein histidine kinase activity
H70737_RS02860	COG0745	RESPONSE REGULATOR receiver
H70737_RS02865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H70737_RS02870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H70737_RS02875	COG0058	SHG alpha-glucan phosphorylase activity
H70737_RS02880	COG1956	GAF domain-containing protein
H70737_RS02895	COG0477	Major facilitator Superfamily
H70737_RS02900	COG1846	Transcriptional regulator
H70737_RS02905	COG2814	Major facilitator Superfamily
H70737_RS02910	COG1131	(ABC) transporter
H70737_RS02920	COG2081	HI0933 family
H70737_RS02925	COG5002	protein histidine kinase activity
H70737_RS02935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H70737_RS02945	COG0736	holo-[acyl-carrier-protein] synthase activity
H70737_RS02955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H70737_RS02970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H70737_RS02980	COG0302	gtp cyclohydrolase
H70737_RS02985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H70737_RS02995	COG1414	Transcriptional regulator
H70737_RS03000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H70737_RS03020	COG4294	response to UV
H70737_RS03025	COG0483	inositol monophosphate 1-phosphatase activity
H70737_RS03040	COG0242	peptide deformylase activity
H70737_RS03055	COG1316	TRANSCRIPTIONal
H70737_RS03060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H70737_RS03075	COG2378	regulation of single-species biofilm formation
H70737_RS03080	COG0586	Pfam SNARE associated Golgi protein
H70737_RS03085	COG0726	polysaccharide deacetylase
H70737_RS03095	COG1305	Transglutaminase-like
H70737_RS03100	COG0519	Catalyzes the synthesis of GMP from XMP
H70737_RS03100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H70737_RS03105	COG0813	purine-nucleoside phosphorylase activity
H70737_RS03110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H70737_RS03115	COG2188	Transcriptional regulator
H70737_RS03120	COG2272	Belongs to the type-B carboxylesterase lipase family
H70737_RS03140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H70737_RS03160	COG2252	PERMEase
H70737_RS03180	COG0463	Glycosyl transferase, family 2
H70737_RS03235	COG1720	tRNA m6t6A37 methyltransferase activity
H70737_RS03245	COG2814	Major facilitator Superfamily
H70737_RS03250	COG3326	Membrane
H70737_RS03255	COG0589	response to stress
H70737_RS03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H70737_RS03265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H70737_RS03270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H70737_RS03280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H70737_RS03285	COG0047	phosphoribosylformylglycinamidine synthase activity
H70737_RS03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H70737_RS03295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H70737_RS03305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H70737_RS03310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H70737_RS03320	COG0151	Belongs to the GarS family
H70737_RS03325	COG0653	protein targeting
H70737_RS03330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H70737_RS03350	COG1073	alpha beta
H70737_RS03355	COG3384	dioxygenase
H70737_RS03360	COG1470	cell adhesion involved in biofilm formation
H70737_RS03365	COG1392	Phosphate transport regulator
H70737_RS03370	COG0306	phosphate transporter
H70737_RS03385	COG0598	Magnesium transport protein CorA
H70737_RS03395	COG4496	protein, YerC YecD
H70737_RS03405	COG1597	lipid kinase activity
H70737_RS03410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H70737_RS03420	COG4974	Belongs to the 'phage' integrase family
H70737_RS03480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H70737_RS03495	COG3976	FMN-binding domain protein
H70737_RS03495	COG1053	succinate dehydrogenase
H70737_RS03530	COG1476	TRANSCRIPTIONal
H70737_RS03545	COG0513	Belongs to the DEAD box helicase family
H70737_RS03550	COG0494	nUDIX hydrolase
H70737_RS03595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS03600	COG0431	NADPH-dependent FMN reductase
H70737_RS03615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS03615	COG2207	Transcriptional regulator
H70737_RS03620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H70737_RS03630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS03635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS03650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H70737_RS03660	COG2249	NAD(P)H dehydrogenase (quinone) activity
H70737_RS03665	COG1733	regulation of RNA biosynthetic process
H70737_RS03685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H70737_RS03690	COG5426	von Willebrand factor, type A
H70737_RS03700	COG3279	Response regulator of the LytR AlgR family
H70737_RS03720	COG1136	(ABC) transporter
H70737_RS03750	COG3022	response to hydroperoxide
H70737_RS03760	COG1132	(ABC) transporter
H70737_RS03765	COG1132	(ABC) transporter
H70737_RS03780	COG0519	Catalyzes the synthesis of GMP from XMP
H70737_RS03810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H70737_RS03815	COG1846	Transcriptional regulator
H70737_RS03835	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H70737_RS03860	COG0784	Response regulator, receiver
H70737_RS03860	COG2198	Histidine kinase
H70737_RS03860	COG5002	protein histidine kinase activity
H70737_RS03865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H70737_RS03875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS03875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS03885	COG1609	Transcriptional regulator
H70737_RS03895	COG1175	transmembrane transport
H70737_RS03905	COG0366	Alpha amylase catalytic
H70737_RS03910	COG0366	Alpha amylase catalytic
H70737_RS03920	COG1609	Transcriptional regulator
H70737_RS03935	COG1175	transmembrane transport
H70737_RS03940	COG0395	ABC-type sugar transport system, permease component
H70737_RS03980	COG1122	ATPase activity
H70737_RS03990	COG2205	protein histidine kinase activity
H70737_RS03995	COG0745	RESPONSE REGULATOR receiver
H70737_RS04000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H70737_RS04015	COG0534	Mate efflux family protein
H70737_RS04030	COG0745	RESPONSE REGULATOR receiver
H70737_RS04035	COG5002	protein histidine kinase activity
H70737_RS04065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H70737_RS04080	COG2911	Protein conserved in bacteria
H70737_RS04080	COG1361	Conserved repeat domain
H70737_RS04080	COG3266	domain, Protein
H70737_RS04180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H70737_RS04190	COG0753	catalase activity
H70737_RS04195	COG0058	SHG alpha-glucan phosphorylase activity
H70737_RS04200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H70737_RS04205	COG0710	3-dehydroquinate dehydratase activity
H70737_RS04210	COG0789	Transcriptional regulator
H70737_RS04230	COG4209	transmembrane transport
H70737_RS04235	COG0395	ABC-type sugar transport system, permease component
H70737_RS04260	COG2207	Transcriptional regulator
H70737_RS04260	COG4753	response regulator
H70737_RS04265	COG2972	Histidine kinase
H70737_RS04275	COG1175	transmembrane transport
H70737_RS04330	COG0673	inositol 2-dehydrogenase activity
H70737_RS04340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H70737_RS04355	COG1501	Belongs to the glycosyl hydrolase 31 family
H70737_RS04370	COG2972	Histidine kinase
H70737_RS04385	COG1653	transport
H70737_RS04390	COG1874	Beta-galactosidase
H70737_RS04410	COG4474	Belongs to the UPF0398 family
H70737_RS04415	COG0154	amidase activity
H70737_RS04425	COG5002	protein histidine kinase activity
H70737_RS04430	COG0745	RESPONSE REGULATOR receiver
H70737_RS04440	COG0494	nUDIX hydrolase
H70737_RS04460	COG0655	NAD(P)H dehydrogenase (quinone) activity
H70737_RS04465	COG3708	Transcriptional regulator
H70737_RS04500	COG2304	oxidoreductase activity
H70737_RS04525	COG0840	transmembrane signaling receptor activity
H70737_RS04530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H70737_RS04535	COG1845	cytochrome c oxidase, subunit III
H70737_RS04545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H70737_RS04550	COG0726	polysaccharide deacetylase
H70737_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H70737_RS04560	COG0765	amino acid transport
H70737_RS04565	COG1126	abc transporter atp-binding protein
H70737_RS04570	COG1725	Transcriptional regulator
H70737_RS04575	COG1131	(ABC) transporter
H70737_RS04585	COG3541	Predicted nucleotidyltransferase
H70737_RS04590	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
H70737_RS04600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H70737_RS04605	COG1011	Hydrolase
H70737_RS04610	COG0346	lactoylglutathione lyase activity
H70737_RS04615	COG2746	aminoglycoside 3-N-acetyltransferase activity
H70737_RS04620	COG1227	inorganic diphosphatase activity
H70737_RS04630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H70737_RS04645	COG2205	protein histidine kinase activity
H70737_RS04650	COG2205	protein histidine kinase activity
H70737_RS04685	COG2197	response regulator
H70737_RS04695	COG0489	protein tyrosine kinase activity
H70737_RS04700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H70737_RS04705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H70737_RS04710	COG1215	transferase activity, transferring glycosyl groups
H70737_RS04720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H70737_RS04740	COG0438	transferase activity, transferring glycosyl groups
H70737_RS04745	COG0438	transferase activity, transferring glycosyl groups
H70737_RS04755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H70737_RS04760	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H70737_RS04760	COG0662	Cupin 2, conserved barrel domain protein
H70737_RS04765	COG2133	pyrroloquinoline quinone binding
H70737_RS04765	COG5183	chlorophyll binding
H70737_RS04770	COG5183	chlorophyll binding
H70737_RS04770	COG2133	pyrroloquinoline quinone binding
H70737_RS04790	COG0783	Belongs to the Dps family
H70737_RS04820	COG0725	ABC transporter, periplasmic molybdate-binding protein
H70737_RS04825	COG4149	molybdate abc transporter
H70737_RS04830	COG1910	domain protein
H70737_RS04850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H70737_RS04860	COG0456	acetyltransferase
H70737_RS04860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H70737_RS04875	COG3773	Cell wall hydrolase
H70737_RS04880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H70737_RS04890	COG1309	transcriptional regulator
H70737_RS04895	COG1511	domain protein
H70737_RS04900	COG0067	glutamate synthase
H70737_RS04900	COG0069	glutamate synthase activity
H70737_RS04900	COG0070	glutamate synthase
H70737_RS04905	COG1131	(ABC) transporter
H70737_RS04910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H70737_RS04920	COG0739	heme binding
H70737_RS04925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H70737_RS04930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS04935	COG3285	dna ligase
H70737_RS04935	COG1793	dna ligase
H70737_RS04970	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H70737_RS04980	COG0802	atpase or kinase
H70737_RS04985	COG1214	PFAM Peptidase M22, glycoprotease
H70737_RS04990	COG0456	acetyltransferase
H70737_RS04995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H70737_RS05000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H70737_RS05005	COG0488	(ABC) transporter
H70737_RS05010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H70737_RS05015	COG0315	cyclic pyranopterin monophosphate synthase activity
H70737_RS05020	COG0521	Mo-molybdopterin cofactor biosynthetic process
H70737_RS05025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H70737_RS05030	COG0805	protein transport
H70737_RS05035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H70737_RS05040	COG0459	protein refolding
H70737_RS05045	COG1940	carbohydrate kinase activity
H70737_RS05050	COG0363	glucosamine-6-phosphate deaminase activity
H70737_RS05065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H70737_RS05070	COG2207	Transcriptional regulator
H70737_RS05075	COG4209	transmembrane transport
H70737_RS05080	COG0395	ABC-type sugar transport system, permease component
H70737_RS05100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H70737_RS05110	COG2814	Major facilitator Superfamily
H70737_RS05125	COG1349	DNA-binding transcription factor activity
H70737_RS05130	COG2807	transmembrane transport
H70737_RS05135	COG2508	Transcriptional regulator
H70737_RS05145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H70737_RS05150	COG1304	FMN binding
H70737_RS05160	COG0549	Belongs to the carbamate kinase family
H70737_RS05165	COG1953	Uracil, thiamine, allantoin
H70737_RS05170	COG0590	tRNA wobble adenosine to inosine editing
H70737_RS05180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H70737_RS05190	COG0840	transmembrane signaling receptor activity
H70737_RS05195	COG0346	lactoylglutathione lyase activity
H70737_RS05200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H70737_RS05205	COG1309	transcriptional regulator
H70737_RS05210	COG2084	Dehydrogenase
H70737_RS05220	COG0657	acetylesterase activity
H70737_RS05230	COG1846	Transcriptional regulator
H70737_RS05235	COG2814	Major facilitator Superfamily
H70737_RS05245	COG0737	Belongs to the 5'-nucleotidase family
H70737_RS05255	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H70737_RS05275	COG0667	Aldo Keto reductase
H70737_RS05280	COG2207	Transcriptional regulator
H70737_RS05290	COG1494	fructose-1,6-bisphosphatase
H70737_RS05295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H70737_RS05300	COG0517	IMP dehydrogenase activity
H70737_RS05305	COG0697	spore germination
H70737_RS05310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS05320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H70737_RS05325	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H70737_RS05345	COG0577	efflux transmembrane transporter activity
H70737_RS05350	COG1136	(ABC) transporter
H70737_RS05355	COG2205	protein histidine kinase activity
H70737_RS05360	COG0745	RESPONSE REGULATOR receiver
H70737_RS05370	COG0406	alpha-ribazole phosphatase activity
H70737_RS05375	COG5001	Diguanylate cyclase
H70737_RS05375	COG3300	MHYT domain
H70737_RS05380	COG2211	Major facilitator Superfamily
H70737_RS05385	COG0584	glycerophosphoryl diester phosphodiesterase
H70737_RS05395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H70737_RS05415	COG0154	amidase activity
H70737_RS05435	COG0366	Alpha amylase catalytic
H70737_RS05440	COG0395	ABC-type sugar transport system, permease component
H70737_RS05445	COG1175	transmembrane transport
H70737_RS05450	COG1653	transport
H70737_RS05465	COG0673	inositol 2-dehydrogenase activity
H70737_RS05480	COG3142	Participates in the control of copper homeostasis
H70737_RS05490	COG1376	ErfK ybiS ycfS ynhG family protein
H70737_RS05495	COG0488	(ABC) transporter
H70737_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS05540	COG0745	RESPONSE REGULATOR receiver
H70737_RS05555	COG0084	hydrolase, TatD family'
H70737_RS05570	COG1846	Transcriptional regulator
H70737_RS05590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H70737_RS05595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H70737_RS05605	COG2337	Toxic component of a toxin-antitoxin (TA) module
H70737_RS05615	COG2814	Major facilitator Superfamily
H70737_RS05620	COG2183	response to ionizing radiation
H70737_RS05625	COG0840	transmembrane signaling receptor activity
H70737_RS05625	COG3290	protein histidine kinase activity
H70737_RS05630	COG1349	DNA-binding transcription factor activity
H70737_RS05635	COG3842	ATPase activity
H70737_RS05640	COG1178	ABC-type Fe3 transport system permease component
H70737_RS05665	COG0322	excinuclease ABC activity
H70737_RS05680	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS05700	COG1595	DNA-templated transcription, initiation
H70737_RS05705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H70737_RS05705	COG2755	lipolytic protein G-D-S-L family
H70737_RS05730	COG0457	Tetratricopeptide repeat
H70737_RS05740	COG3091	SprT-like family
H70737_RS05755	COG1522	sequence-specific DNA binding
H70737_RS05760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H70737_RS05790	COG2226	methyltransferase
H70737_RS05825	COG0386	Belongs to the glutathione peroxidase family
H70737_RS05835	COG3011	Protein conserved in bacteria
H70737_RS05900	COG1090	epimerase
H70737_RS05910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H70737_RS05915	COG0788	formyltetrahydrofolate deformylase activity
H70737_RS05975	COG0456	acetyltransferase
H70737_RS06000	COG0166	Belongs to the GPI family
H70737_RS06005	COG1739	Uncharacterized protein family UPF0029
H70737_RS06010	COG1309	transcriptional regulator
H70737_RS06015	COG0432	Pfam Uncharacterised protein family UPF0047
H70737_RS06020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H70737_RS06025	COG4208	sulfate ABC transporter
H70737_RS06035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H70737_RS06040	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H70737_RS06040	COG0321	lipoyl(octanoyl) transferase activity
H70737_RS06050	COG1132	(ABC) transporter
H70737_RS06055	COG0561	phosphatase activity
H70737_RS06070	COG0095	Lipoate-protein ligase
H70737_RS06080	COG0024	Methionine aminopeptidase
H70737_RS06085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H70737_RS06100	COG0406	alpha-ribazole phosphatase activity
H70737_RS06115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS06125	COG0436	Aminotransferase
H70737_RS06130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H70737_RS06135	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
H70737_RS06140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H70737_RS06145	COG1742	UPF0060 membrane protein
H70737_RS06150	COG3290	protein histidine kinase activity
H70737_RS06150	COG0840	transmembrane signaling receptor activity
H70737_RS06155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H70737_RS06160	COG0318	PFAM AMP-dependent synthetase and ligase
H70737_RS06165	COG0183	Belongs to the thiolase family
H70737_RS06185	COG1122	ATPase activity
H70737_RS06190	COG1122	ATPase activity
H70737_RS06195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H70737_RS06205	COG2267	carboxylic ester hydrolase activity
H70737_RS06210	COG0006	proline dipeptidase activity
H70737_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS06220	COG1247	-acetyltransferase
H70737_RS06225	COG1733	regulation of RNA biosynthetic process
H70737_RS06235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS06240	COG4605	iron ion homeostasis
H70737_RS06245	COG4604	ABC transporter, ATP-binding protein
H70737_RS06250	COG4607	ABC-type enterochelin transport system periplasmic component
H70737_RS06255	COG1595	DNA-templated transcription, initiation
H70737_RS06270	COG0456	acetyltransferase
H70737_RS06295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H70737_RS06300	COG4716	Myosin-crossreactive antigen
H70737_RS06325	COG0564	pseudouridine synthase activity
H70737_RS06340	COG0814	amino acid
H70737_RS06345	COG0697	spore germination
H70737_RS06350	COG0514	ATP-dependent DNA helicase (RecQ)
H70737_RS06355	COG1032	radical SAM domain protein
H70737_RS06365	COG1482	cell wall glycoprotein biosynthetic process
H70737_RS06370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H70737_RS06375	COG1242	4 iron, 4 sulfur cluster binding
H70737_RS06385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H70737_RS06390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H70737_RS06395	COG0671	phosphoesterase, PA-phosphatase related
H70737_RS06400	COG1215	transferase activity, transferring glycosyl groups
H70737_RS06410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H70737_RS06415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H70737_RS06420	COG1607	acyl-coa hydrolase
H70737_RS06425	COG1744	ABC transporter substrate-binding protein PnrA-like
H70737_RS06430	COG3845	ABC transporter
H70737_RS06435	COG4603	Belongs to the binding-protein-dependent transport system permease family
H70737_RS06440	COG1079	Belongs to the binding-protein-dependent transport system permease family
H70737_RS06455	COG0028	Belongs to the TPP enzyme family
H70737_RS06460	COG0440	acetolactate synthase activity
H70737_RS06465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H70737_RS06470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H70737_RS06485	COG2972	Histidine kinase
H70737_RS06490	COG2207	Transcriptional regulator
H70737_RS06490	COG4753	response regulator
H70737_RS06495	COG1653	transport
H70737_RS06500	COG4209	transmembrane transport
H70737_RS06505	COG0395	ABC-type sugar transport system, permease component
H70737_RS06525	COG3279	Response regulator of the LytR AlgR family
H70737_RS06530	COG2972	Histidine kinase
H70737_RS06530	COG0745	RESPONSE REGULATOR receiver
H70737_RS06555	COG0667	Aldo Keto reductase
H70737_RS06560	COG0473	3-isopropylmalate dehydrogenase activity
H70737_RS06565	COG0450	alkyl hydroperoxide reductase
H70737_RS06575	COG4191	Histidine kinase
H70737_RS06580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H70737_RS06605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H70737_RS06610	COG1733	regulation of RNA biosynthetic process
H70737_RS06620	COG1051	belongs to the nudix hydrolase family
H70737_RS06630	COG0488	(ABC) transporter
H70737_RS06640	COG2059	Chromate
H70737_RS06645	COG2059	Chromate
H70737_RS06650	COG0405	Gamma-glutamyltransferase
H70737_RS06655	COG0154	amidase activity
H70737_RS06670	COG2508	Transcriptional regulator
H70737_RS06675	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H70737_RS06690	COG3845	ABC transporter
H70737_RS06695	COG1079	Belongs to the binding-protein-dependent transport system permease family
H70737_RS06700	COG1079	Belongs to the binding-protein-dependent transport system permease family
H70737_RS06710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H70737_RS06715	COG2080	2 iron, 2 sulfur cluster binding
H70737_RS06725	COG3195	allantoin biosynthetic process
H70737_RS06725	COG3648	Uricase
H70737_RS06730	COG2351	hydroxyisourate hydrolase activity
H70737_RS06735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H70737_RS06740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H70737_RS06745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H70737_RS06750	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H70737_RS06760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H70737_RS06770	COG3481	metal-dependent phosphohydrolase, HD sub domain
H70737_RS06780	COG2304	oxidoreductase activity
H70737_RS06785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H70737_RS06810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H70737_RS06815	COG0697	spore germination
H70737_RS06840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H70737_RS06845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H70737_RS06850	COG1780	Probably involved in ribonucleotide reductase function
H70737_RS06860	COG2199	diguanylate cyclase activity
H70737_RS06860	COG2203	Gaf domain
H70737_RS06865	COG3940	Belongs to the glycosyl hydrolase 43 family
H70737_RS06870	COG0395	ABC-type sugar transport system, permease component
H70737_RS06875	COG1175	transmembrane transport
H70737_RS06880	COG1653	transport
H70737_RS06885	COG1609	Transcriptional regulator
H70737_RS06890	COG0154	amidase activity
H70737_RS06905	COG0673	inositol 2-dehydrogenase activity
H70737_RS06955	COG0789	Transcriptional regulator
H70737_RS06960	COG1064	alcohol dehydrogenase
H70737_RS06965	COG1609	Transcriptional regulator
H70737_RS06970	COG4209	transmembrane transport
H70737_RS06975	COG0395	ABC-type sugar transport system, permease component
H70737_RS06985	COG1621	beta-fructofuranosidase activity
H70737_RS06990	COG1940	carbohydrate kinase activity
H70737_RS07010	COG3852	Histidine kinase
H70737_RS07015	COG1199	ATP-dependent helicase activity
H70737_RS07025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H70737_RS07030	COG3693	PFAM glycoside hydrolase, family 10
H70737_RS07035	COG2409	Drug exporters of the RND superfamily
H70737_RS07045	COG2814	Major facilitator Superfamily
H70737_RS07050	COG1309	transcriptional regulator
H70737_RS07055	COG2182	Extracellular solute-binding protein
H70737_RS07070	COG0346	lactoylglutathione lyase activity
H70737_RS07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS07085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS07090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS07110	COG2207	Transcriptional regulator
H70737_RS07110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS07115	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS07120	COG2814	Major facilitator Superfamily
H70737_RS07130	COG1522	sequence-specific DNA binding
H70737_RS07135	COG2205	protein histidine kinase activity
H70737_RS07175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H70737_RS07190	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS07210	COG2076	Multidrug Resistance protein
H70737_RS07215	COG2076	Multidrug Resistance protein
H70737_RS07220	COG0656	L-ascorbic acid biosynthetic process
H70737_RS07225	COG1363	Peptidase, m42
H70737_RS07235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H70737_RS07245	COG0714	Associated with various cellular activities
H70737_RS07260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H70737_RS07265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H70737_RS07270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H70737_RS07275	COG1534	Rna-binding protein
H70737_RS07280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H70737_RS07285	COG1713	HD superfamily hydrolase involved in NAD metabolism
H70737_RS07290	COG0799	negative regulation of ribosome biogenesis
H70737_RS07295	COG2996	Protein conserved in bacteria
H70737_RS07300	COG2226	methyltransferase
H70737_RS07320	COG3940	Belongs to the glycosyl hydrolase 43 family
H70737_RS07335	COG0667	Aldo Keto reductase
H70737_RS07345	COG1349	DNA-binding transcription factor activity
H70737_RS07350	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
H70737_RS07355	COG1070	Carbohydrate kinase
H70737_RS07360	COG0235	Class ii aldolase
H70737_RS07365	COG4154	Belongs to the RbsD FucU family
H70737_RS07370	COG2207	Transcriptional regulator
H70737_RS07370	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS07375	COG0673	inositol 2-dehydrogenase activity
H70737_RS07395	COG2972	Histidine kinase
H70737_RS07400	COG2207	Transcriptional regulator
H70737_RS07400	COG4753	response regulator
H70737_RS07405	COG1175	transmembrane transport
H70737_RS07410	COG0395	ABC-type sugar transport system, permease component
H70737_RS07415	COG1653	transport
H70737_RS07430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H70737_RS07435	COG2312	Erythromycin esterase
H70737_RS07445	COG5002	protein histidine kinase activity
H70737_RS07450	COG2323	membrane
H70737_RS07455	COG3534	alpha-L-arabinofuranosidase
H70737_RS07475	COG3507	Belongs to the glycosyl hydrolase 43 family
H70737_RS07495	COG0395	ABC-type sugar transport system, permease component
H70737_RS07500	COG3940	Belongs to the glycosyl hydrolase 43 family
H70737_RS07510	COG1131	(ABC) transporter
H70737_RS07525	COG1595	DNA-templated transcription, initiation
H70737_RS07560	COG0477	Major facilitator Superfamily
H70737_RS07570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H70737_RS07580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H70737_RS07590	COG0534	Mate efflux family protein
H70737_RS07605	COG4472	Bacterial protein of unknown function (DUF965)
H70737_RS07615	COG3906	Belongs to the UPF0473 family
H70737_RS07625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H70737_RS07630	COG0826	peptidase U32
H70737_RS07635	COG0826	peptidase U32
H70737_RS07640	COG0840	transmembrane signaling receptor activity
H70737_RS07645	COG2972	Histidine kinase
H70737_RS07655	COG1609	Transcriptional regulator
H70737_RS07665	COG3546	catalase activity
H70737_RS07670	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H70737_RS07685	COG2207	Transcriptional regulator
H70737_RS07685	COG4753	response regulator
H70737_RS07690	COG2182	Extracellular solute-binding protein
H70737_RS07695	COG1175	transmembrane transport
H70737_RS07700	COG0395	ABC-type sugar transport system, permease component
H70737_RS07705	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H70737_RS07710	COG3458	cephalosporin-C deacetylase activity
H70737_RS07715	COG0840	transmembrane signaling receptor activity
H70737_RS07730	COG2972	Histidine kinase
H70737_RS07735	COG2207	Transcriptional regulator
H70737_RS07745	COG0768	penicillin binding
H70737_RS07750	COG0628	permease
H70737_RS07765	COG3594	Acyltransferase
H70737_RS07770	COG0596	Alpha beta hydrolase
H70737_RS07780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H70737_RS07785	COG0667	Aldo Keto reductase
H70737_RS07800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H70737_RS07805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H70737_RS07810	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H70737_RS07815	COG1979	alcohol dehydrogenase
H70737_RS07825	COG2268	Band 7 protein
H70737_RS07830	COG1131	(ABC) transporter
H70737_RS07840	COG3711	transcriptional antiterminator
H70737_RS07845	COG1263	PTS System
H70737_RS07845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS07845	COG2190	(PTS) system
H70737_RS07855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H70737_RS07860	COG1523	belongs to the glycosyl hydrolase 13 family
H70737_RS07870	COG0577	efflux transmembrane transporter activity
H70737_RS07875	COG1136	(ABC) transporter
H70737_RS07875	COG0577	efflux transmembrane transporter activity
H70737_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H70737_RS07890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H70737_RS07920	COG1193	negative regulation of DNA recombination
H70737_RS07925	COG3766	membrane
H70737_RS07950	COG1522	sequence-specific DNA binding
H70737_RS07955	COG0436	Aminotransferase
H70737_RS07965	COG2096	Adenosyltransferase
H70737_RS07970	COG0564	pseudouridine synthase activity
H70737_RS07975	COG1393	Belongs to the ArsC family
H70737_RS07985	COG1609	Transcriptional regulator
H70737_RS07995	COG1175	transmembrane transport
H70737_RS08000	COG0395	ABC-type sugar transport system, permease component
H70737_RS08010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H70737_RS08015	COG1940	carbohydrate kinase activity
H70737_RS08025	COG0598	Magnesium transport protein CorA
H70737_RS08030	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H70737_RS08035	COG0626	cystathionine gamma-synthase activity
H70737_RS08040	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H70737_RS08055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H70737_RS08060	COG3584	3D domain protein
H70737_RS08070	COG4585	Histidine kinase
H70737_RS08075	COG2197	response regulator
H70737_RS08080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H70737_RS08085	COG0745	RESPONSE REGULATOR receiver
H70737_RS08090	COG5002	protein histidine kinase activity
H70737_RS08095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H70737_RS08100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H70737_RS08105	COG0174	glutamine synthetase
H70737_RS08120	COG1175	transmembrane transport
H70737_RS08125	COG0395	ABC-type sugar transport system, permease component
H70737_RS08145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H70737_RS08150	COG2002	toxin-antitoxin pair type II binding
H70737_RS08155	COG5434	Belongs to the glycosyl hydrolase 28 family
H70737_RS08155	COG4632	Exopolysaccharide biosynthesis protein
H70737_RS08170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS08185	COG2766	serine protein kinase
H70737_RS08190	COG2207	Transcriptional regulator
H70737_RS08190	COG3708	Transcriptional regulator
H70737_RS08200	COG2719	SpoVR family
H70737_RS08210	COG1653	transport
H70737_RS08220	COG4209	transmembrane transport
H70737_RS08225	COG0395	ABC-type sugar transport system, permease component
H70737_RS08230	COG1309	transcriptional regulator
H70737_RS08235	COG2814	Major facilitator Superfamily
H70737_RS08245	COG4753	response regulator
H70737_RS08245	COG2207	Transcriptional regulator
H70737_RS08260	COG0395	ABC-type sugar transport system, permease component
H70737_RS08265	COG4209	transmembrane transport
H70737_RS08275	COG4209	transmembrane transport
H70737_RS08280	COG0395	ABC-type sugar transport system, permease component
H70737_RS08320	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H70737_RS08360	COG0745	RESPONSE REGULATOR receiver
H70737_RS08365	COG2205	protein histidine kinase activity
H70737_RS08370	COG1131	(ABC) transporter
H70737_RS08380	COG3850	Histidine kinase
H70737_RS08380	COG3437	response regulator, receiver
H70737_RS08380	COG2205	protein histidine kinase activity
H70737_RS08380	COG4999	Histidine kinase
H70737_RS08385	COG1307	EDD domain protein, DegV family
H70737_RS08390	COG3708	Transcriptional regulator
H70737_RS08390	COG2207	Transcriptional regulator
H70737_RS08395	COG0366	Alpha amylase catalytic
H70737_RS08400	COG1554	hydrolase, family 65, central catalytic
H70737_RS08405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H70737_RS08410	COG1609	Transcriptional regulator
H70737_RS08415	COG1874	Beta-galactosidase
H70737_RS08415	COG0366	Alpha amylase catalytic
H70737_RS08425	COG2182	Extracellular solute-binding protein
H70737_RS08430	COG1175	transmembrane transport
H70737_RS08435	COG3833	ABC-type maltose transport systems, permease component
H70737_RS08440	COG0840	transmembrane signaling receptor activity
H70737_RS08450	COG1486	melibiose metabolic process
H70737_RS08455	COG2718	Belongs to the UPF0229 family
H70737_RS08485	COG2363	Small membrane protein
H70737_RS08495	COG3377	Domain of unknown function (DUF1805)
H70737_RS08500	COG0783	Belongs to the Dps family
H70737_RS08505	COG0396	ATPase activity
H70737_RS08510	COG0719	Fe-S assembly protein
H70737_RS08515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H70737_RS08520	COG0822	iron-sulfur transferase activity
H70737_RS08525	COG0719	Fe-S assembly protein
H70737_RS08530	COG1132	(ABC) transporter
H70737_RS08535	COG1132	(ABC) transporter
H70737_RS08545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H70737_RS08545	COG2199	diguanylate cyclase activity
H70737_RS08550	COG0314	molybdopterin synthase activity
H70737_RS08555	COG0737	Belongs to the 5'-nucleotidase family
H70737_RS08570	COG0535	radical SAM domain protein
H70737_RS08575	COG1253	flavin adenine dinucleotide binding
H70737_RS08580	COG0745	RESPONSE REGULATOR receiver
H70737_RS08585	COG2205	protein histidine kinase activity
H70737_RS08590	COG1183	phosphatidylcholine synthase activity
H70737_RS08595	COG0586	Pfam SNARE associated Golgi protein
H70737_RS08600	COG0628	permease
H70737_RS08615	COG3546	catalase activity
H70737_RS08625	COG1280	lysine exporter protein (LysE YggA)
H70737_RS08635	COG2315	Protein conserved in bacteria
H70737_RS08680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H70737_RS08695	COG2207	Transcriptional regulator
H70737_RS08700	COG2723	6-phospho-beta-galactosidase activity
H70737_RS08705	COG1263	PTS System
H70737_RS08705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS08705	COG2190	(PTS) system
H70737_RS08730	COG0110	maltose O-acetyltransferase activity
H70737_RS08745	COG0583	DNA-binding transcription factor activity
H70737_RS08760	COG1131	(ABC) transporter
H70737_RS08770	COG2972	Histidine kinase
H70737_RS08770	COG0745	RESPONSE REGULATOR receiver
H70737_RS08775	COG3279	Response regulator of the LytR AlgR family
H70737_RS08780	COG1595	DNA-templated transcription, initiation
H70737_RS08795	COG0667	Aldo Keto reductase
H70737_RS08800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H70737_RS08815	COG2843	Capsule synthesis protein
H70737_RS08820	COG2002	toxin-antitoxin pair type II binding
H70737_RS08850	COG0189	ligase activity
H70737_RS08860	COG0189	ligase activity
H70737_RS08865	COG0189	ligase activity
H70737_RS08875	COG0189	ligase activity
H70737_RS08880	COG3679	Belongs to the UPF0342 family
H70737_RS08900	COG4109	DRTGG domain
H70737_RS08925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H70737_RS08935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H70737_RS08940	COG0825	malonyl-CoA metabolic process
H70737_RS08945	COG0469	pyruvate kinase activity
H70737_RS08960	COG0824	Thioesterase
H70737_RS08965	COG3030	protein affecting phage T7 exclusion by the F plasmid
H70737_RS08970	COG0628	permease
H70737_RS08975	COG0372	Belongs to the citrate synthase family
H70737_RS08980	COG0538	isocitrate dehydrogenase activity
H70737_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS09015	COG5002	protein histidine kinase activity
H70737_RS09020	COG0745	RESPONSE REGULATOR receiver
H70737_RS09025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H70737_RS09030	COG0704	Plays a role in the regulation of phosphate uptake
H70737_RS09035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H70737_RS09035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H70737_RS09040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H70737_RS09045	COG1971	Probably functions as a manganese efflux pump
H70737_RS09050	COG0237	dephospho-CoA kinase activity
H70737_RS09055	COG1196	nuclear chromosome segregation
H70737_RS09055	COG0741	lytic transglycosylase activity
H70737_RS09055	COG0739	heme binding
H70737_RS09065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H70737_RS09090	COG1361	Conserved repeat domain
H70737_RS09095	COG3693	PFAM glycoside hydrolase, family 10
H70737_RS09110	COG2972	Histidine kinase
H70737_RS09115	COG2207	Transcriptional regulator
H70737_RS09125	COG1175	transmembrane transport
H70737_RS09130	COG0395	ABC-type sugar transport system, permease component
H70737_RS09140	COG2814	Major facilitator Superfamily
H70737_RS09150	COG3275	phosphorelay sensor kinase activity
H70737_RS09155	COG1653	transport
H70737_RS09160	COG2207	Transcriptional regulator
H70737_RS09170	COG0366	Alpha amylase catalytic
H70737_RS09170	COG1470	cell adhesion involved in biofilm formation
H70737_RS09200	COG1653	transport
H70737_RS09205	COG1175	transmembrane transport
H70737_RS09210	COG0395	ABC-type sugar transport system, permease component
H70737_RS09220	COG0346	lactoylglutathione lyase activity
H70737_RS09255	COG1442	glycosyl transferase family 8
H70737_RS09260	COG1072	(Pantothenic acid kinase))
H70737_RS09295	COG3693	PFAM glycoside hydrolase, family 10
H70737_RS09310	COG1045	serine acetyltransferase
H70737_RS09320	COG3401	FG-GAP repeat protein
H70737_RS09340	COG4948	Mandelate Racemase Muconate Lactonizing
H70737_RS09345	COG2755	lipolytic protein G-D-S-L family
H70737_RS09350	COG2207	Transcriptional regulator
H70737_RS09355	COG1653	transport
H70737_RS09360	COG1653	transport
H70737_RS09365	COG4209	transmembrane transport
H70737_RS09370	COG0395	ABC-type sugar transport system, permease component
H70737_RS09375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H70737_RS09380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H70737_RS09390	COG1073	alpha beta
H70737_RS09405	COG0693	protein deglycase activity
H70737_RS09435	COG2207	Transcriptional regulator
H70737_RS09440	COG0656	L-ascorbic acid biosynthetic process
H70737_RS09445	COG1199	ATP-dependent helicase activity
H70737_RS09455	COG0789	Transcriptional regulator
H70737_RS09460	COG1053	succinate dehydrogenase
H70737_RS09460	COG3976	FMN-binding domain protein
H70737_RS09475	COG5492	domain, Protein
H70737_RS09485	COG0840	transmembrane signaling receptor activity
H70737_RS09500	COG0740	serine-type endopeptidase activity
H70737_RS09515	COG0366	Alpha amylase catalytic
H70737_RS09520	COG1368	sulfuric ester hydrolase activity
H70737_RS09545	COG1428	Deoxynucleoside kinase
H70737_RS09550	COG1428	Deoxynucleoside kinase
H70737_RS09565	COG1653	transport
H70737_RS09570	COG4209	transmembrane transport
H70737_RS09575	COG0395	ABC-type sugar transport system, permease component
H70737_RS09580	COG1063	alcohol dehydrogenase
H70737_RS09590	COG0438	transferase activity, transferring glycosyl groups
H70737_RS09595	COG0673	inositol 2-dehydrogenase activity
H70737_RS09605	COG0673	inositol 2-dehydrogenase activity
H70737_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS09620	COG3386	PFAM SMP-30 Gluconolaconase
H70737_RS09625	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS09640	COG0129	dihydroxy-acid dehydratase activity
H70737_RS09645	COG0129	dihydroxy-acid dehydratase activity
H70737_RS09660	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H70737_RS09690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H70737_RS09695	COG0385	Bile acid
H70737_RS09700	COG0840	transmembrane signaling receptor activity
H70737_RS09710	COG1418	mRNA catabolic process
H70737_RS09720	COG1132	(ABC) transporter
H70737_RS09725	COG2807	transmembrane transport
H70737_RS09730	COG4106	trans-aconitate 2-methyltransferase activity
H70737_RS09750	COG2205	protein histidine kinase activity
H70737_RS09750	COG0784	Response regulator, receiver
H70737_RS09765	COG0701	Predicted permease
H70737_RS09770	COG0523	cobalamin synthesis protein
H70737_RS09775	COG0523	cobalamin synthesis protein
H70737_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS09805	COG2445	Protein of unknown function DUF86
H70737_RS09820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H70737_RS09840	COG4844	belongs to the
H70737_RS09845	COG1368	sulfuric ester hydrolase activity
H70737_RS09850	COG0116	Belongs to the methyltransferase superfamily
H70737_RS09860	COG2814	Major facilitator Superfamily
H70737_RS09865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H70737_RS09870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H70737_RS09875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H70737_RS09880	COG2843	Capsule synthesis protein
H70737_RS09885	COG0584	glycerophosphoryl diester phosphodiesterase
H70737_RS09900	COG1309	transcriptional regulator
H70737_RS09905	COG0488	(ABC) transporter
H70737_RS09920	COG1363	Peptidase, m42
H70737_RS09925	COG5416	Lipopolysaccharide assembly protein A domain
H70737_RS09930	COG1164	Oligoendopeptidase f
H70737_RS09940	COG1278	Cold shock
H70737_RS09975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS09980	COG0513	Belongs to the DEAD box helicase family
H70737_RS10000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H70737_RS10005	COG0705	Rhomboid family
H70737_RS10010	COG0583	DNA-binding transcription factor activity
H70737_RS10015	COG2738	Putative neutral zinc metallopeptidase
H70737_RS10025	COG0004	ammonium transporteR
H70737_RS10045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H70737_RS10050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H70737_RS10055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H70737_RS10060	COG1141	Ferredoxin
H70737_RS10065	COG1376	ErfK ybiS ycfS ynhG family protein
H70737_RS10070	COG0167	dihydroorotate dehydrogenase activity
H70737_RS10075	COG2357	RelA SpoT domain protein
H70737_RS10080	COG1547	Domain of unknown function (DUF309)
H70737_RS10085	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H70737_RS10085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H70737_RS10090	COG1187	pseudouridine synthase activity
H70737_RS10095	COG0561	phosphatase activity
H70737_RS10105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H70737_RS10120	COG4555	ABC transporter
H70737_RS10145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H70737_RS10145	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H70737_RS10150	COG0438	transferase activity, transferring glycosyl groups
H70737_RS10155	COG0420	3'-5' exonuclease activity
H70737_RS10160	COG4717	serine-type aminopeptidase activity
H70737_RS10165	COG3949	Membrane
H70737_RS10170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H70737_RS10205	COG1131	(ABC) transporter
H70737_RS10215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H70737_RS10220	COG1404	Belongs to the peptidase S8 family
H70737_RS10230	COG0789	Transcriptional regulator
H70737_RS10230	COG4978	Transcriptional regulator
H70737_RS10260	COG1120	ATPase activity
H70737_RS10265	COG0748	coenzyme F420 binding
H70737_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS10300	COG2861	carbohydrate metabolic process
H70737_RS10305	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS10315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H70737_RS10325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H70737_RS10340	COG0295	cytidine deaminase activity
H70737_RS10355	COG1733	regulation of RNA biosynthetic process
H70737_RS10365	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS10365	COG4977	sequence-specific DNA binding
H70737_RS10370	COG0110	maltose O-acetyltransferase activity
H70737_RS10380	COG0346	lactoylglutathione lyase activity
H70737_RS10385	COG0110	maltose O-acetyltransferase activity
H70737_RS10390	COG2318	DinB family
H70737_RS10395	COG2207	Transcriptional regulator
H70737_RS10395	COG4753	response regulator
H70737_RS10400	COG2972	Histidine kinase
H70737_RS10410	COG1175	transmembrane transport
H70737_RS10415	COG0395	ABC-type sugar transport system, permease component
H70737_RS10450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H70737_RS10455	COG0189	ligase activity
H70737_RS10470	COG2423	ornithine cyclodeaminase activity
H70737_RS10475	COG0583	DNA-binding transcription factor activity
H70737_RS10480	COG0534	Mate efflux family protein
H70737_RS10495	COG4753	response regulator
H70737_RS10495	COG2207	Transcriptional regulator
H70737_RS10515	COG3275	phosphorelay sensor kinase activity
H70737_RS10520	COG4753	response regulator
H70737_RS10520	COG2207	Transcriptional regulator
H70737_RS10525	COG4209	transmembrane transport
H70737_RS10530	COG0395	ABC-type sugar transport system, permease component
H70737_RS10535	COG1653	transport
H70737_RS10550	COG0383	alpha-mannosidase activity
H70737_RS10555	COG1846	Transcriptional regulator
H70737_RS10560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H70737_RS10565	COG1609	Transcriptional regulator
H70737_RS10580	COG2318	DinB family
H70737_RS10585	COG2378	regulation of single-species biofilm formation
H70737_RS10590	COG1309	transcriptional regulator
H70737_RS10610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS10615	COG4607	ABC-type enterochelin transport system periplasmic component
H70737_RS10645	COG1609	Transcriptional regulator
H70737_RS10655	COG4209	transmembrane transport
H70737_RS10660	COG0395	ABC-type sugar transport system, permease component
H70737_RS10690	COG0351	phosphomethylpyrimidine kinase
H70737_RS10695	COG0457	Tetratricopeptide repeat
H70737_RS10695	COG0463	Glycosyl transferase, family 2
H70737_RS10700	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS10700	COG2207	Transcriptional regulator
H70737_RS10710	COG1653	transport
H70737_RS10715	COG4209	transmembrane transport
H70737_RS10720	COG0395	ABC-type sugar transport system, permease component
H70737_RS10725	COG1653	transport
H70737_RS10750	COG2267	carboxylic ester hydrolase activity
H70737_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS10760	COG3347	Dehydrogenase
H70737_RS10765	COG1349	DNA-binding transcription factor activity
H70737_RS10770	COG0247	lactate metabolic process
H70737_RS10775	COG1139	Iron-sulfur cluster binding protein
H70737_RS10780	COG1556	Lactate utilization protein
H70737_RS10785	COG1070	Carbohydrate kinase
H70737_RS10795	COG4806	L-rhamnose isomerase
H70737_RS10810	COG1733	regulation of RNA biosynthetic process
H70737_RS10815	COG0778	Nitroreductase
H70737_RS10820	COG1380	Effector of murein hydrolase LrgA
H70737_RS10825	COG1346	cytolysis
H70737_RS10845	COG1683	Conserved Protein
H70737_RS10855	COG1051	belongs to the nudix hydrolase family
H70737_RS10870	COG2205	protein histidine kinase activity
H70737_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS10920	COG1694	Mazg nucleotide pyrophosphohydrolase
H70737_RS10925	COG1611	Belongs to the LOG family
H70737_RS10930	COG2357	RelA SpoT domain protein
H70737_RS10940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H70737_RS10945	COG0390	transport system, permease component
H70737_RS10965	COG0604	alcohol dehydrogenase
H70737_RS10980	COG2205	protein histidine kinase activity
H70737_RS10995	COG2318	DinB family
H70737_RS11020	COG0840	transmembrane signaling receptor activity
H70737_RS11030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H70737_RS11040	COG4585	Histidine kinase
H70737_RS11050	COG4549	nuclear export factor GLE1
H70737_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS11085	COG0583	DNA-binding transcription factor activity
H70737_RS11100	COG2814	Major facilitator Superfamily
H70737_RS11125	COG0592	DNA-directed DNA polymerase activity
H70737_RS11135	COG0778	Nitroreductase
H70737_RS11150	COG1252	NADH dehydrogenase
H70737_RS11165	COG0024	Methionine aminopeptidase
H70737_RS11180	COG2270	Major facilitator Superfamily
H70737_RS11195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS11200	COG1959	2 iron, 2 sulfur cluster binding
H70737_RS11215	COG3340	Belongs to the peptidase S51 family
H70737_RS11230	COG2514	catechol 2,3-dioxygenase activity
H70737_RS11240	COG2910	NAD(P)H-binding
H70737_RS11245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS11250	COG0025	NhaP-type Na H and K H
H70737_RS11270	COG2966	Psort location CytoplasmicMembrane, score
H70737_RS11275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H70737_RS11280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS11285	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS11285	COG2207	Transcriptional regulator
H70737_RS11300	COG3459	Glycosyltransferase 36 associated
H70737_RS11305	COG1609	Transcriptional regulator
H70737_RS11315	COG2207	Transcriptional regulator
H70737_RS11330	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS11405	COG1234	tRNA 3'-trailer cleavage
H70737_RS11415	COG3906	Belongs to the UPF0473 family
H70737_RS11420	COG1982	Orn Lys Arg decarboxylase major
H70737_RS11435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H70737_RS11440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H70737_RS11445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H70737_RS11450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H70737_RS11455	COG1832	CoA-binding protein
H70737_RS11470	COG2190	(PTS) system
H70737_RS11470	COG1263	PTS System
H70737_RS11470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS11475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H70737_RS11480	COG1595	DNA-templated transcription, initiation
H70737_RS11490	COG0693	protein deglycase activity
H70737_RS11500	COG1609	Transcriptional regulator
H70737_RS11510	COG0454	-acetyltransferase
H70737_RS11515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H70737_RS11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H70737_RS11525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H70737_RS11530	COG2203	Gaf domain
H70737_RS11530	COG2199	diguanylate cyclase activity
H70737_RS11540	COG2309	aminopeptidase activity
H70737_RS11550	COG4838	Belongs to the UPF0358 family
H70737_RS11555	COG0387	Pfam Sodium calcium exchanger
H70737_RS11565	COG0772	Belongs to the SEDS family
H70737_RS11575	COG1473	amidohydrolase
H70737_RS11580	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H70737_RS11585	COG1061	Type III restriction enzyme res subunit
H70737_RS11610	COG0583	DNA-binding transcription factor activity
H70737_RS11615	COG0613	PHP domain protein
H70737_RS11620	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H70737_RS11625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H70737_RS11630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H70737_RS11635	COG0697	spore germination
H70737_RS11645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H70737_RS11650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H70737_RS11650	COG0646	methionine synthase
H70737_RS11655	COG1561	YicC-like family, N-terminal region
H70737_RS11660	COG2052	Domain of unknown function (DUF370)
H70737_RS11665	COG0194	GDP metabolic process
H70737_RS11670	COG1758	RNA polymerase activity
H70737_RS11675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H70737_RS11680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H70737_RS11685	COG0242	peptide deformylase activity
H70737_RS11690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H70737_RS11695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H70737_RS11695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H70737_RS11705	COG0631	protein serine/threonine phosphatase activity
H70737_RS11710	COG2815	serine threonine protein kinase
H70737_RS11710	COG0515	serine threonine protein kinase
H70737_RS11715	COG1162	GTPase activity
H70737_RS11720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H70737_RS11730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H70737_RS11735	COG1461	Dihydroxyacetone kinase
H70737_RS11740	COG1307	EDD domain protein, DegV family
H70737_RS11745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H70737_RS11775	COG0791	NLP P60 protein
H70737_RS11785	COG4120	Belongs to the binding-protein-dependent transport system permease family
H70737_RS11790	COG1116	anion transmembrane transporter activity
H70737_RS11790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H70737_RS11795	COG2972	Histidine kinase
H70737_RS11800	COG2207	Transcriptional regulator
H70737_RS11800	COG4753	response regulator
H70737_RS11805	COG1653	transport
H70737_RS11810	COG1175	transmembrane transport
H70737_RS11815	COG0395	ABC-type sugar transport system, permease component
H70737_RS11820	COG2755	lipolytic protein G-D-S-L family
H70737_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS11830	COG1285	pathogenesis
H70737_RS11835	COG2017	converts alpha-aldose to the beta-anomer
H70737_RS11840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H70737_RS11865	COG4876	unkown
H70737_RS11870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H70737_RS11880	COG2706	6-phosphogluconolactonase activity
H70737_RS11885	COG1923	regulation of RNA biosynthetic process
H70737_RS11890	COG0671	phosphoesterase, PA-phosphatase related
H70737_RS11900	COG4129	membrane
H70737_RS11905	COG3973	AAA domain
H70737_RS11910	COG2814	Major facilitator Superfamily
H70737_RS11915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H70737_RS11930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H70737_RS11945	COG1846	Transcriptional regulator
H70737_RS11950	COG2409	Drug exporters of the RND superfamily
H70737_RS11950	COG1033	growth of symbiont in host cell
H70737_RS11955	COG3397	chitin binding
H70737_RS11970	COG1611	Belongs to the LOG family
H70737_RS11980	COG1971	Probably functions as a manganese efflux pump
H70737_RS12000	COG0395	ABC-type sugar transport system, permease component
H70737_RS12005	COG2972	Histidine kinase
H70737_RS12015	COG2207	Transcriptional regulator
H70737_RS12015	COG4753	response regulator
H70737_RS12020	COG3239	Fatty acid desaturase
H70737_RS12025	COG4585	Histidine kinase
H70737_RS12030	COG2197	response regulator
H70737_RS12050	COG1187	pseudouridine synthase activity
H70737_RS12060	COG0351	phosphomethylpyrimidine kinase
H70737_RS12065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H70737_RS12070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H70737_RS12075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS12080	COG1116	anion transmembrane transporter activity
H70737_RS12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H70737_RS12090	COG0765	amino acid transport
H70737_RS12095	COG1126	abc transporter atp-binding protein
H70737_RS12105	COG0735	belongs to the Fur family
H70737_RS12120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H70737_RS12135	COG0673	inositol 2-dehydrogenase activity
H70737_RS12140	COG0673	inositol 2-dehydrogenase activity
H70737_RS12155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H70737_RS12165	COG0444	Belongs to the ABC transporter superfamily
H70737_RS12170	COG3507	Belongs to the glycosyl hydrolase 43 family
H70737_RS12175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H70737_RS12195	COG0708	Exodeoxyribonuclease III
H70737_RS12220	COG0180	Tryptophanyl-tRNA synthetase
H70737_RS12230	COG1733	regulation of RNA biosynthetic process
H70737_RS12235	COG1595	DNA-templated transcription, initiation
H70737_RS12245	COG0488	(ABC) transporter
H70737_RS12250	COG3275	phosphorelay sensor kinase activity
H70737_RS12255	COG4753	response regulator
H70737_RS12255	COG2207	Transcriptional regulator
H70737_RS12265	COG1175	transmembrane transport
H70737_RS12270	COG0395	ABC-type sugar transport system, permease component
H70737_RS12275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H70737_RS12280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H70737_RS12310	COG0583	DNA-binding transcription factor activity
H70737_RS12325	COG4245	von Willebrand factor, type A
H70737_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS12355	COG1733	regulation of RNA biosynthetic process
H70737_RS12375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS12380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS12385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS12405	COG0640	Transcriptional regulator
H70737_RS12415	COG2111	Na H antiporter
H70737_RS12415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H70737_RS12420	COG1006	Multisubunit Na H antiporter MnhC subunit
H70737_RS12425	COG0651	ATP synthesis coupled electron transport
H70737_RS12430	COG1863	multisubunit Na H antiporter MnhE subunit
H70737_RS12435	COG2212	antiporter activity
H70737_RS12440	COG1320	monovalent cation:proton antiporter activity
H70737_RS12450	COG1309	transcriptional regulator
H70737_RS12455	COG2814	Major facilitator Superfamily
H70737_RS12460	COG2368	4-hydroxyphenylacetate
H70737_RS12505	COG0653	protein targeting
H70737_RS12515	COG5002	protein histidine kinase activity
H70737_RS12515	COG3850	Histidine kinase
H70737_RS12520	COG0745	RESPONSE REGULATOR receiver
H70737_RS12550	COG1131	(ABC) transporter
H70737_RS12560	COG1725	Transcriptional regulator
H70737_RS12565	COG1131	(ABC) transporter
H70737_RS12585	COG1388	LysM domain
H70737_RS12585	COG1705	Flagellar rod assembly protein muramidase FlgJ
H70737_RS12605	COG0742	ribosomal rna small subunit methyltransferase
H70737_RS12610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H70737_RS12615	COG3314	Sporulation integral membrane protein YlbJ
H70737_RS12620	COG3480	Lon protease (S16) C-terminal proteolytic domain
H70737_RS12625	COG1323	Belongs to the UPF0348 family
H70737_RS12635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H70737_RS12640	COG1349	DNA-binding transcription factor activity
H70737_RS12645	COG0416	fatty acid biosynthetic process
H70737_RS12655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H70737_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS12665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H70737_RS12670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H70737_RS12680	COG1196	nuclear chromosome segregation
H70737_RS12685	COG0552	protein localization to endoplasmic reticulum
H70737_RS12695	COG2308	Evidence 4 Homologs of previously reported genes of
H70737_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS12730	COG1643	Atp-dependent helicase
H70737_RS12765	COG0745	RESPONSE REGULATOR receiver
H70737_RS12770	COG5002	protein histidine kinase activity
H70737_RS12770	COG3850	Histidine kinase
H70737_RS12780	COG1840	ABC-type Fe3 transport system, periplasmic component
H70737_RS12790	COG3842	ATPase activity
H70737_RS12810	COG3711	transcriptional antiterminator
H70737_RS12815	COG2190	(PTS) system
H70737_RS12820	COG2190	(PTS) system
H70737_RS12820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS12820	COG1263	PTS System
H70737_RS12840	COG1131	(ABC) transporter
H70737_RS12850	COG1733	regulation of RNA biosynthetic process
H70737_RS12855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H70737_RS12855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H70737_RS12860	COG4555	ABC transporter
H70737_RS12880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H70737_RS12885	COG0640	Transcriptional regulator
H70737_RS12890	COG2814	Major facilitator Superfamily
H70737_RS12895	COG1525	nuclease
H70737_RS12920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS12925	COG1940	carbohydrate kinase activity
H70737_RS12955	COG1309	transcriptional regulator
H70737_RS12960	COG0477	Major facilitator Superfamily
H70737_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS12980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H70737_RS12990	COG2814	Major facilitator Superfamily
H70737_RS12995	COG0697	spore germination
H70737_RS13005	COG1609	Transcriptional regulator
H70737_RS13010	COG0673	inositol 2-dehydrogenase activity
H70737_RS13030	COG0662	Cupin 2, conserved barrel domain protein
H70737_RS13030	COG2207	Transcriptional regulator
H70737_RS13040	COG0673	inositol 2-dehydrogenase activity
H70737_RS13045	COG1011	Hydrolase
H70737_RS13050	COG0454	-acetyltransferase
H70737_RS13065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H70737_RS13070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H70737_RS13095	COG0384	phenazine biosynthesis protein PhzF
H70737_RS13100	COG0494	nUDIX hydrolase
H70737_RS13110	COG0583	DNA-binding transcription factor activity
H70737_RS13115	COG2391	methyltransferase activity
H70737_RS13120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H70737_RS13120	COG0425	Belongs to the sulfur carrier protein TusA family
H70737_RS13135	COG4209	transmembrane transport
H70737_RS13140	COG0395	ABC-type sugar transport system, permease component
H70737_RS13150	COG2197	response regulator
H70737_RS13155	COG0745	RESPONSE REGULATOR receiver
H70737_RS13155	COG2972	Histidine kinase
H70737_RS13165	COG2323	membrane
H70737_RS13170	COG0697	spore germination
H70737_RS13185	COG0714	Associated with various cellular activities
H70737_RS13205	COG1136	(ABC) transporter
H70737_RS13210	COG0577	efflux transmembrane transporter activity
H70737_RS13220	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS13225	COG1528	Iron-storage protein
H70737_RS13230	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H70737_RS13235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H70737_RS13240	COG2703	oxygen carrier activity
H70737_RS13245	COG1408	metallophosphoesterase
H70737_RS13265	COG0745	RESPONSE REGULATOR receiver
H70737_RS13270	COG5002	protein histidine kinase activity
H70737_RS13270	COG3850	Histidine kinase
H70737_RS13275	COG0577	efflux transmembrane transporter activity
H70737_RS13280	COG1136	(ABC) transporter
H70737_RS13285	COG0252	asparaginase activity
H70737_RS13290	COG0583	DNA-binding transcription factor activity
H70737_RS13295	COG1846	Transcriptional regulator
H70737_RS13295	COG0456	acetyltransferase
H70737_RS13305	COG0673	inositol 2-dehydrogenase activity
H70737_RS13330	COG0579	oxidoreductase
H70737_RS13355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H70737_RS13360	COG1725	Transcriptional regulator
H70737_RS13365	COG1131	(ABC) transporter
H70737_RS13385	COG3655	Transcriptional regulator
H70737_RS13395	COG3655	Transcriptional regulator
H70737_RS13400	COG3739	integral membrane protein
H70737_RS13415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H70737_RS13425	COG0667	Aldo Keto reductase
H70737_RS13430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H70737_RS13440	COG0745	RESPONSE REGULATOR receiver
H70737_RS13445	COG5002	protein histidine kinase activity
H70737_RS13450	COG1695	Transcriptional regulator
H70737_RS13455	COG2814	Major facilitator Superfamily
H70737_RS13470	COG1063	alcohol dehydrogenase
H70737_RS13495	COG4632	Exopolysaccharide biosynthesis protein
H70737_RS13495	COG5434	Belongs to the glycosyl hydrolase 28 family
H70737_RS13505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H70737_RS13515	COG0038	chloride channel
H70737_RS13520	COG0488	(ABC) transporter
H70737_RS13525	COG2814	Major facilitator Superfamily
H70737_RS13530	COG0154	amidase activity
H70737_RS13575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H70737_RS13600	COG0583	DNA-binding transcription factor activity
H70737_RS13605	COG2814	Major facilitator Superfamily
H70737_RS13610	COG2816	NAD+ diphosphatase activity
H70737_RS13640	COG2226	methyltransferase
H70737_RS13655	COG5002	protein histidine kinase activity
H70737_RS13655	COG3850	Histidine kinase
H70737_RS13670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H70737_RS13675	COG5566	PFAM Mor transcription activator
H70737_RS13680	COG1309	transcriptional regulator
H70737_RS13685	COG1063	alcohol dehydrogenase
H70737_RS13720	COG5566	PFAM Mor transcription activator
H70737_RS13730	COG1388	LysM domain
H70737_RS13745	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H70737_RS13745	COG2755	lipolytic protein G-D-S-L family
H70737_RS13755	COG0488	(ABC) transporter
H70737_RS13765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H70737_RS13770	COG0456	acetyltransferase
H70737_RS13780	COG2076	Multidrug Resistance protein
H70737_RS13785	COG2076	Multidrug Resistance protein
H70737_RS13805	COG4941	Belongs to the sigma-70 factor family
H70737_RS13820	COG1846	Transcriptional regulator
H70737_RS13825	COG2814	Major facilitator Superfamily
H70737_RS13865	COG1349	DNA-binding transcription factor activity
H70737_RS13880	COG1175	transmembrane transport
H70737_RS13885	COG0395	ABC-type sugar transport system, permease component
H70737_RS13905	COG1757	Na H antiporter
H70737_RS13920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H70737_RS13925	COG0739	heme binding
H70737_RS13930	COG0745	RESPONSE REGULATOR receiver
H70737_RS13935	COG2205	protein histidine kinase activity
H70737_RS13940	COG0702	epimerase
H70737_RS13955	COG0488	(ABC) transporter
H70737_RS13960	COG2207	Transcriptional regulator
H70737_RS13965	COG0383	alpha-mannosidase activity
H70737_RS13970	COG2972	Histidine kinase
H70737_RS13975	COG4209	transmembrane transport
H70737_RS13980	COG0395	ABC-type sugar transport system, permease component
H70737_RS13985	COG1653	transport
H70737_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
H70737_RS14000	COG3507	Belongs to the glycosyl hydrolase 43 family
H70737_RS14015	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS14020	COG2244	polysaccharide biosynthetic process
H70737_RS14025	COG1657	PFAM Prenyltransferase squalene oxidase
H70737_RS14035	COG1012	belongs to the aldehyde dehydrogenase family
H70737_RS14040	COG0840	transmembrane signaling receptor activity
H70737_RS14050	COG0778	Nitroreductase
H70737_RS14055	COG1132	(ABC) transporter
H70737_RS14060	COG1132	(ABC) transporter
H70737_RS14080	COG1309	transcriptional regulator
H70737_RS14090	COG4977	sequence-specific DNA binding
H70737_RS14095	COG3507	Belongs to the glycosyl hydrolase 43 family
H70737_RS14115	COG2207	Transcriptional regulator
H70737_RS14115	COG4753	response regulator
H70737_RS14140	COG3250	beta-galactosidase activity
H70737_RS14150	COG5434	Belongs to the glycosyl hydrolase 28 family
H70737_RS14155	COG2205	protein histidine kinase activity
H70737_RS14180	COG0395	ABC-type sugar transport system, permease component
H70737_RS14185	COG4209	transmembrane transport
H70737_RS14190	COG4753	response regulator
H70737_RS14190	COG2207	Transcriptional regulator
H70737_RS14195	COG3275	phosphorelay sensor kinase activity
H70737_RS14230	COG1609	Transcriptional regulator
H70737_RS14240	COG0235	Class ii aldolase
H70737_RS14245	COG2160	L-arabinose isomerase activity
H70737_RS14265	COG1764	response to oxidative stress
H70737_RS14275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS14290	COG0745	RESPONSE REGULATOR receiver
H70737_RS14290	COG2972	Histidine kinase
H70737_RS14315	COG2378	regulation of single-species biofilm formation
H70737_RS14320	COG2267	carboxylic ester hydrolase activity
H70737_RS14380	COG0745	RESPONSE REGULATOR receiver
H70737_RS14390	COG0640	Transcriptional regulator
H70737_RS14420	COG1131	(ABC) transporter
H70737_RS14425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H70737_RS14430	COG4753	response regulator
H70737_RS14430	COG2207	Transcriptional regulator
H70737_RS14450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS14460	COG0584	glycerophosphoryl diester phosphodiesterase
H70737_RS14475	COG0673	inositol 2-dehydrogenase activity
H70737_RS14505	COG0456	acetyltransferase
H70737_RS14510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H70737_RS14515	COG0765	amino acid transport
H70737_RS14520	COG0765	amino acid transport
H70737_RS14525	COG1126	abc transporter atp-binding protein
H70737_RS14530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS14535	COG1473	amidohydrolase
H70737_RS14550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS14555	COG1473	amidohydrolase
H70737_RS14570	COG0431	NADPH-dependent FMN reductase
H70737_RS14580	COG4221	oxidoreductase activity
H70737_RS14590	COG0667	Aldo Keto reductase
H70737_RS14595	COG2207	Transcriptional regulator
H70737_RS14605	COG0673	inositol 2-dehydrogenase activity
H70737_RS14625	COG2814	Major facilitator Superfamily
H70737_RS14655	COG1175	transmembrane transport
H70737_RS14660	COG0395	ABC-type sugar transport system, permease component
H70737_RS14690	COG2207	Transcriptional regulator
H70737_RS14690	COG4753	response regulator
H70737_RS14710	COG3693	PFAM glycoside hydrolase, family 10
H70737_RS14725	COG3153	acetyltransferase
H70737_RS14780	COG2186	Transcriptional regulator
H70737_RS14785	COG1119	ATPase activity
H70737_RS14790	COG4977	sequence-specific DNA binding
H70737_RS14835	COG0534	Mate efflux family protein
H70737_RS14840	COG0583	DNA-binding transcription factor activity
H70737_RS14845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H70737_RS14855	COG1268	BioY protein
H70737_RS14865	COG0813	purine-nucleoside phosphorylase activity
H70737_RS14870	COG2233	PERMEase
H70737_RS14875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H70737_RS14880	COG0366	Alpha amylase catalytic
H70737_RS14885	COG1263	PTS System
H70737_RS14885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS14890	COG2188	Transcriptional regulator
H70737_RS14895	COG1414	Transcriptional regulator
H70737_RS14905	COG2814	Major facilitator Superfamily
H70737_RS14930	COG0316	Belongs to the HesB IscA family
H70737_RS14940	COG2207	Transcriptional regulator
H70737_RS14940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS14945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS14950	COG0492	ferredoxin-NADP+ reductase activity
H70737_RS14960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H70737_RS14965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS14970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H70737_RS14975	COG0402	S-adenosylhomocysteine deaminase activity
H70737_RS15005	COG1271	oxidase subunit
H70737_RS15010	COG1294	oxidase, subunit
H70737_RS15020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H70737_RS15030	COG1595	DNA-templated transcription, initiation
H70737_RS15050	COG1309	transcriptional regulator
H70737_RS15055	COG4209	transmembrane transport
H70737_RS15060	COG0395	ABC-type sugar transport system, permease component
H70737_RS15065	COG1653	transport
H70737_RS15070	COG3275	phosphorelay sensor kinase activity
H70737_RS15075	COG2207	Transcriptional regulator
H70737_RS15075	COG4753	response regulator
H70737_RS15110	COG0768	penicillin binding
H70737_RS15115	COG0745	RESPONSE REGULATOR receiver
H70737_RS15120	COG2205	protein histidine kinase activity
H70737_RS15125	COG1131	(ABC) transporter
H70737_RS15165	COG2207	Transcriptional regulator
H70737_RS15165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS15170	COG1653	transport
H70737_RS15175	COG4209	transmembrane transport
H70737_RS15180	COG0395	ABC-type sugar transport system, permease component
H70737_RS15225	COG2972	Histidine kinase
H70737_RS15225	COG0745	RESPONSE REGULATOR receiver
H70737_RS15260	COG0367	asparagine synthase
H70737_RS15265	COG0596	Alpha beta hydrolase
H70737_RS15270	COG4224	UPF0291 protein
H70737_RS15295	COG1131	(ABC) transporter
H70737_RS15300	COG1725	Transcriptional regulator
H70737_RS15315	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H70737_RS15320	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
H70737_RS15325	COG1691	(AIR) carboxylase
H70737_RS15330	COG1070	Carbohydrate kinase
H70737_RS15335	COG1606	tRNA processing
H70737_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS15360	COG0673	inositol 2-dehydrogenase activity
H70737_RS15365	COG0673	inositol 2-dehydrogenase activity
H70737_RS15375	COG2207	Transcriptional regulator
H70737_RS15385	COG2211	Major facilitator Superfamily
H70737_RS15390	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H70737_RS15395	COG3250	beta-galactosidase activity
H70737_RS15400	COG1904	glucuronate isomerase
H70737_RS15415	COG1486	melibiose metabolic process
H70737_RS15425	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H70737_RS15430	COG2814	Major facilitator Superfamily
H70737_RS15445	COG2207	Transcriptional regulator
H70737_RS15445	COG4753	response regulator
H70737_RS15450	COG2972	Histidine kinase
H70737_RS15460	COG1175	transmembrane transport
H70737_RS15465	COG1653	transport
H70737_RS15475	COG0531	amino acid
H70737_RS15480	COG0697	spore germination
H70737_RS15485	COG1201	RNA secondary structure unwinding
H70737_RS15500	COG0477	Major facilitator Superfamily
H70737_RS15510	COG1253	flavin adenine dinucleotide binding
H70737_RS15530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H70737_RS15540	COG2309	aminopeptidase activity
H70737_RS15545	COG2309	aminopeptidase activity
H70737_RS15560	COG1309	transcriptional regulator
H70737_RS15565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS15575	COG3620	sequence-specific DNA binding
H70737_RS15580	COG0778	Nitroreductase
H70737_RS15585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H70737_RS15590	COG0581	inorganic phosphate transmembrane transporter activity
H70737_RS15595	COG0573	inorganic phosphate transmembrane transporter activity
H70737_RS15600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H70737_RS15615	COG2972	Histidine kinase
H70737_RS15620	COG4753	response regulator
H70737_RS15620	COG2207	Transcriptional regulator
H70737_RS15630	COG1172	Belongs to the binding-protein-dependent transport system permease family
H70737_RS15635	COG1129	ABC transporter
H70737_RS15650	COG1063	alcohol dehydrogenase
H70737_RS15655	COG2720	vancomycin resistance protein
H70737_RS15670	COG0720	synthase
H70737_RS15675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H70737_RS15680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H70737_RS15700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H70737_RS15705	COG1120	ATPase activity
H70737_RS15710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS15715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS15720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS15725	COG0531	amino acid
H70737_RS15730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H70737_RS15740	COG1253	flavin adenine dinucleotide binding
H70737_RS15835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H70737_RS15855	COG5518	Phage portal protein
H70737_RS15970	COG3773	Cell wall hydrolase
H70737_RS15985	COG0531	amino acid
H70737_RS15990	COG0039	L-malate dehydrogenase activity
H70737_RS15995	COG4974	Belongs to the 'phage' integrase family
H70737_RS16000	COG0583	DNA-binding transcription factor activity
H70737_RS16005	COG0531	amino acid
H70737_RS16055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H70737_RS16060	COG4533	DNA binding
H70737_RS16065	COG2211	Major facilitator Superfamily
H70737_RS16070	COG2378	regulation of single-species biofilm formation
H70737_RS16075	COG0673	inositol 2-dehydrogenase activity
H70737_RS16085	COG1309	transcriptional regulator
H70737_RS16100	COG0303	'Molybdopterin
H70737_RS16115	COG1842	Phage shock protein A
H70737_RS16125	COG0167	dihydroorotate dehydrogenase activity
H70737_RS16130	COG0543	2 iron, 2 sulfur cluster binding
H70737_RS16135	COG1902	pentaerythritol trinitrate reductase activity
H70737_RS16145	COG1388	LysM domain
H70737_RS16145	COG3584	3D domain protein
H70737_RS16155	COG0248	Ppx GppA phosphatase
H70737_RS16160	COG1126	abc transporter atp-binding protein
H70737_RS16165	COG0765	amino acid transport
H70737_RS16170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H70737_RS16175	COG0297	glycogen (starch) synthase activity
H70737_RS16180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H70737_RS16185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H70737_RS16195	COG5002	protein histidine kinase activity
H70737_RS16200	COG0745	RESPONSE REGULATOR receiver
H70737_RS16215	COG0477	Major facilitator Superfamily
H70737_RS16230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H70737_RS16240	COG1357	PFAM Pentapeptide repeats (8 copies)
H70737_RS16245	COG0442	prolyl-tRNA aminoacylation
H70737_RS16250	COG0493	'glutamate synthase
H70737_RS16255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H70737_RS16265	COG1619	proteins homologs of microcin C7 resistance protein MccF
H70737_RS16280	COG0022	dehydrogenase e1 component
H70737_RS16290	COG2382	esterase
H70737_RS16295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H70737_RS16300	COG1564	THIamine pyrophosphokinase
H70737_RS16315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H70737_RS16320	COG0488	(ABC) transporter
H70737_RS16330	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H70737_RS16335	COG1119	ATPase activity
H70737_RS16350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H70737_RS16360	COG0647	UMP catabolic process
H70737_RS16365	COG1234	tRNA 3'-trailer cleavage
H70737_RS16370	COG1410	methionine synthase
H70737_RS16370	COG0646	methionine synthase
H70737_RS16380	COG1011	Hydrolase
H70737_RS16390	COG4224	UPF0291 protein
H70737_RS16400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H70737_RS16405	COG1376	ErfK ybiS ycfS ynhG family protein
H70737_RS16420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS16500	COG0174	glutamine synthetase
H70737_RS16505	COG0789	Transcriptional regulator
H70737_RS16510	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H70737_RS16515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H70737_RS16520	COG0464	growth
H70737_RS16535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H70737_RS16540	COG1923	regulation of RNA biosynthetic process
H70737_RS16545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H70737_RS16550	COG2521	methyltransferase
H70737_RS16550	COG2136	Putative SAM-dependent methyltransferase
H70737_RS16555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H70737_RS16560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H70737_RS16585	COG4129	membrane
H70737_RS16590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS16595	COG1116	anion transmembrane transporter activity
H70737_RS16600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H70737_RS16620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H70737_RS16630	COG1011	Hydrolase
H70737_RS16640	COG0640	Transcriptional regulator
H70737_RS16645	COG0492	ferredoxin-NADP+ reductase activity
H70737_RS16650	COG2707	UPF0756 membrane protein
H70737_RS16660	COG1595	DNA-templated transcription, initiation
H70737_RS16665	COG1132	(ABC) transporter
H70737_RS16680	COG1132	(ABC) transporter
H70737_RS16685	COG1132	(ABC) transporter
H70737_RS16705	COG0523	cobalamin synthesis protein
H70737_RS16710	COG0521	Mo-molybdopterin cofactor biosynthetic process
H70737_RS16720	COG0674	pyruvate-flavodoxin oxidoreductase activity
H70737_RS16730	COG1113	amino acid transport
H70737_RS16750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H70737_RS16755	COG1335	isochorismatase
H70737_RS16765	COG4550	Control of competence regulator ComK, YlbF/YmcA
H70737_RS16770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H70737_RS16775	COG3552	Protein containing von Willebrand factor type A (VWA) domain
H70737_RS16785	COG0714	Associated with various cellular activities
H70737_RS16805	COG0235	Class ii aldolase
H70737_RS16810	COG4806	L-rhamnose isomerase
H70737_RS16815	COG1070	Carbohydrate kinase
H70737_RS16820	COG1454	alcohol dehydrogenase
H70737_RS16825	COG1349	DNA-binding transcription factor activity
H70737_RS16835	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H70737_RS16840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H70737_RS16845	COG3588	fructose-bisphosphate aldolase
H70737_RS16855	COG2207	Transcriptional regulator
H70737_RS16875	COG0395	ABC-type sugar transport system, permease component
H70737_RS16880	COG1175	transmembrane transport
H70737_RS16910	COG3250	beta-galactosidase activity
H70737_RS16955	COG3279	Response regulator of the LytR AlgR family
H70737_RS16960	COG2972	Histidine kinase
H70737_RS16960	COG0745	RESPONSE REGULATOR receiver
H70737_RS16970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS16980	COG0789	Transcriptional regulator
H70737_RS16980	COG4978	Transcriptional regulator
H70737_RS17000	COG3119	arylsulfatase activity
H70737_RS17020	COG0395	ABC-type sugar transport system, permease component
H70737_RS17025	COG4209	transmembrane transport
H70737_RS17030	COG4753	response regulator
H70737_RS17030	COG2207	Transcriptional regulator
H70737_RS17040	COG3119	arylsulfatase activity
H70737_RS17045	COG2169	Transcriptional regulator
H70737_RS17045	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS17050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H70737_RS17055	COG2059	Chromate
H70737_RS17065	COG1846	Transcriptional regulator
H70737_RS17065	COG1940	carbohydrate kinase activity
H70737_RS17100	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H70737_RS17105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H70737_RS17115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H70737_RS17130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H70737_RS17140	COG1086	Polysaccharide biosynthesis protein
H70737_RS17145	COG0438	transferase activity, transferring glycosyl groups
H70737_RS17160	COG0489	protein tyrosine kinase activity
H70737_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS17195	COG1132	(ABC) transporter
H70737_RS17210	COG3832	glyoxalase III activity
H70737_RS17220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS17225	COG2207	Transcriptional regulator
H70737_RS17225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS17230	COG0789	Transcriptional regulator
H70737_RS17230	COG4978	Transcriptional regulator
H70737_RS17240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H70737_RS17245	COG0463	Glycosyl transferase, family 2
H70737_RS17265	COG0673	inositol 2-dehydrogenase activity
H70737_RS17280	COG1175	transmembrane transport
H70737_RS17300	COG0840	transmembrane signaling receptor activity
H70737_RS17315	COG0395	ABC-type sugar transport system, permease component
H70737_RS17325	COG1653	transport
H70737_RS17330	COG3275	phosphorelay sensor kinase activity
H70737_RS17335	COG4753	response regulator
H70737_RS17335	COG2207	Transcriptional regulator
H70737_RS17375	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS17380	COG3173	Aminoglycoside phosphotransferase
H70737_RS17440	COG0386	Belongs to the glutathione peroxidase family
H70737_RS17445	COG2807	transmembrane transport
H70737_RS17450	COG0583	DNA-binding transcription factor activity
H70737_RS17480	COG2318	DinB family
H70737_RS17500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H70737_RS17530	COG0702	epimerase
H70737_RS17540	COG1846	Transcriptional regulator
H70737_RS17550	COG2226	methyltransferase
H70737_RS17650	COG1595	DNA-templated transcription, initiation
H70737_RS17660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H70737_RS17675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H70737_RS17680	COG2169	Transcriptional regulator
H70737_RS17685	COG0789	Transcriptional regulator
H70737_RS17690	COG1027	Aspartate ammonia-lyase
H70737_RS17700	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H70737_RS17705	COG1349	DNA-binding transcription factor activity
H70737_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS17725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H70737_RS17735	COG1874	Beta-galactosidase
H70737_RS17750	COG1056	cytidyltransferase-related domain
H70737_RS17750	COG1051	belongs to the nudix hydrolase family
H70737_RS17820	COG1846	Transcriptional regulator
H70737_RS17825	COG0456	acetyltransferase
H70737_RS17830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H70737_RS17845	COG1131	(ABC) transporter
H70737_RS17850	COG4326	sporulation control protein
H70737_RS17855	COG1132	(ABC) transporter
H70737_RS17865	COG0583	DNA-binding transcription factor activity
H70737_RS17870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H70737_RS17885	COG0583	DNA-binding transcription factor activity
H70737_RS17925	COG0513	Belongs to the DEAD box helicase family
H70737_RS17930	COG4869	propanediol catabolic process
H70737_RS17940	COG2359	stage V sporulation protein S
H70737_RS17945	COG1692	metallophosphoesterase
H70737_RS17955	COG2137	regulation of response to DNA damage stimulus
H70737_RS17970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H70737_RS17980	COG1426	Protein conserved in bacteria
H70737_RS17995	COG0300	oxidoreductase activity
H70737_RS18000	COG0612	Peptidase, M16
H70737_RS18005	COG0612	Peptidase, M16
H70737_RS18015	COG4980	gas vesicle protein
H70737_RS18015	COG1674	ftsk spoiiie
H70737_RS18025	COG0740	serine-type endopeptidase activity
H70737_RS18030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H70737_RS18035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H70737_RS18040	COG0527	aspartate kinase activity
H70737_RS18045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H70737_RS18050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H70737_RS18055	COG0756	dUTP diphosphatase activity
H70737_RS18060	COG0612	Peptidase, M16
H70737_RS18070	COG1185	polyribonucleotide nucleotidyltransferase activity
H70737_RS18075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H70737_RS18080	COG0196	riboflavin kinase activity
H70737_RS18085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H70737_RS18090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H70737_RS18095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H70737_RS18100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H70737_RS18105	COG1358	cellular component organization or biogenesis
H70737_RS18110	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H70737_RS18115	COG0195	Participates in both transcription termination and antitermination
H70737_RS18120	COG0779	Required for maturation of 30S ribosomal subunits
H70737_RS18125	COG2176	DNA-directed DNA polymerase activity
H70737_RS18130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H70737_RS18135	COG0750	zinc metalloprotease
H70737_RS18140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H70737_RS18145	COG4589	Belongs to the CDS family
H70737_RS18150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H70737_RS18155	COG0233	cytoplasmic translational termination
H70737_RS18160	COG0528	UMP kinase activity
H70737_RS18165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H70737_RS18170	COG0052	Belongs to the universal ribosomal protein uS2 family
H70737_RS18195	COG1191	sigma factor activity
H70737_RS18205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H70737_RS18210	COG1776	CheC inhibitor of MCP methylation
H70737_RS18215	COG0835	chemotaxis
H70737_RS18220	COG0643	Histidine kinase
H70737_RS18220	COG2198	Histidine kinase
H70737_RS18225	COG2201	protein-glutamate methylesterase activity
H70737_RS18230	COG0455	bacterial-type flagellum organization
H70737_RS18235	COG1419	protein localization to endoplasmic reticulum
H70737_RS18240	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H70737_RS18245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H70737_RS18250	COG1684	flagellar biosynthetic protein fliR
H70737_RS18255	COG1987	bacterial-type flagellum assembly
H70737_RS18260	COG1338	Plays a role in the flagellum-specific transport system
H70737_RS18265	COG3190	flagellar
H70737_RS18270	COG2201	protein-glutamate methylesterase activity
H70737_RS18275	COG1776	CheC inhibitor of MCP methylation
H70737_RS18275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H70737_RS18280	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H70737_RS18295	COG4786	Flagellar basal body rod
H70737_RS18305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H70737_RS18325	COG1157	protein secretion by the type III secretion system
H70737_RS18335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H70737_RS18340	COG1766	The M ring may be actively involved in energy transduction
H70737_RS18345	COG1677	Flagellar hook-basal body complex protein FliE
H70737_RS18350	COG1558	bacterial-type flagellum-dependent cell motility
H70737_RS18360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H70737_RS18365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H70737_RS18370	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H70737_RS18375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H70737_RS18380	COG0758	DNA mediated transformation
H70737_RS18380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H70737_RS18385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H70737_RS18390	COG0045	succinate-CoA ligase (ADP-forming) activity
H70737_RS18395	COG1846	Transcriptional regulator
H70737_RS18400	COG1764	response to oxidative stress
H70737_RS18405	COG0606	chelatase, subunit chli
H70737_RS18420	COG0792	nuclease activity
H70737_RS18435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H70737_RS18450	COG0335	large ribosomal subunit rRNA binding
H70737_RS18470	COG0336	Belongs to the RNA methyltransferase TrmD family
H70737_RS18475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H70737_RS18485	COG0228	four-way junction DNA binding
H70737_RS18490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H70737_RS18495	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H70737_RS18500	COG1272	protein, Hemolysin III
H70737_RS18505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H70737_RS18515	COG0288	reversible hydration of carbon dioxide
H70737_RS18530	COG1619	proteins homologs of microcin C7 resistance protein MccF
H70737_RS18545	COG0628	permease
H70737_RS18575	COG1846	Transcriptional regulator
H70737_RS18595	COG1122	ATPase activity
H70737_RS18620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H70737_RS18625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H70737_RS18645	COG2226	methyltransferase
H70737_RS18665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H70737_RS18680	COG2011	ABC-type metal ion transport system permease component
H70737_RS18685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H70737_RS18690	COG1473	amidohydrolase
H70737_RS18700	COG0733	neurotransmitter:sodium symporter activity
H70737_RS18705	COG0395	ABC-type sugar transport system, permease component
H70737_RS18710	COG4209	transmembrane transport
H70737_RS18715	COG2972	Histidine kinase
H70737_RS18720	COG2207	Transcriptional regulator
H70737_RS18740	COG2972	Histidine kinase
H70737_RS18740	COG0745	RESPONSE REGULATOR receiver
H70737_RS18745	COG0666	response to abiotic stimulus
H70737_RS18755	COG0745	RESPONSE REGULATOR receiver
H70737_RS18760	COG5002	protein histidine kinase activity
H70737_RS18765	COG1082	Xylose isomerase domain protein TIM barrel
H70737_RS18770	COG0583	DNA-binding transcription factor activity
H70737_RS18775	COG0667	Aldo Keto reductase
H70737_RS18815	COG1263	PTS System
H70737_RS18815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS18825	COG2971	BadF BadG BcrA BcrD
H70737_RS18830	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS18835	COG3876	Protein conserved in bacteria
H70737_RS18850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H70737_RS18855	COG0395	ABC-type sugar transport system, permease component
H70737_RS18860	COG1175	transmembrane transport
H70737_RS18870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H70737_RS18875	COG1737	Transcriptional regulator
H70737_RS18880	COG2409	Drug exporters of the RND superfamily
H70737_RS18880	COG1033	growth of symbiont in host cell
H70737_RS18890	COG0745	RESPONSE REGULATOR receiver
H70737_RS18895	COG2205	protein histidine kinase activity
H70737_RS18905	COG0577	efflux transmembrane transporter activity
H70737_RS18910	COG1136	(ABC) transporter
H70737_RS18925	COG1785	Belongs to the alkaline phosphatase family
H70737_RS18955	COG4753	response regulator
H70737_RS18955	COG2207	Transcriptional regulator
H70737_RS18960	COG2972	Histidine kinase
H70737_RS18975	COG0395	ABC-type sugar transport system, permease component
H70737_RS18980	COG4209	transmembrane transport
H70737_RS18995	COG2207	Transcriptional regulator
H70737_RS19020	COG3493	citrate carrier protein
H70737_RS19025	COG4565	transcriptional regulatory protein
H70737_RS19030	COG3290	protein histidine kinase activity
H70737_RS19055	COG0110	maltose O-acetyltransferase activity
H70737_RS19060	COG0583	DNA-binding transcription factor activity
H70737_RS19065	COG1151	hydroxylamine reductase activity
H70737_RS19070	COG2814	Major facilitator Superfamily
H70737_RS19075	COG0697	spore germination
H70737_RS19095	COG0477	Major facilitator Superfamily
H70737_RS19105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H70737_RS19115	COG0697	spore germination
H70737_RS19125	COG2340	Cysteine-rich secretory protein family
H70737_RS19140	COG1396	sequence-specific DNA binding
H70737_RS19160	COG1316	TRANSCRIPTIONal
H70737_RS19165	COG0772	Belongs to the SEDS family
H70737_RS19175	COG5002	protein histidine kinase activity
H70737_RS19180	COG0745	RESPONSE REGULATOR receiver
H70737_RS19185	COG0673	inositol 2-dehydrogenase activity
H70737_RS19195	COG0673	inositol 2-dehydrogenase activity
H70737_RS19215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H70737_RS19220	COG1349	DNA-binding transcription factor activity
H70737_RS19230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H70737_RS19245	COG0395	ABC-type sugar transport system, permease component
H70737_RS19250	COG1175	transmembrane transport
H70737_RS19265	COG1653	transport
H70737_RS19270	COG2197	response regulator
H70737_RS19275	COG2972	Histidine kinase
H70737_RS19295	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS19330	COG4191	Histidine kinase
H70737_RS19335	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS19335	COG2207	Transcriptional regulator
H70737_RS19340	COG0697	spore germination
H70737_RS19375	COG4753	response regulator
H70737_RS19375	COG2207	Transcriptional regulator
H70737_RS19380	COG2972	Histidine kinase
H70737_RS19405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS19405	COG2207	Transcriptional regulator
H70737_RS19415	COG2340	Cysteine-rich secretory protein family
H70737_RS19420	COG1846	Transcriptional regulator
H70737_RS19425	COG0477	Major facilitator Superfamily
H70737_RS19435	COG2323	membrane
H70737_RS19440	COG2205	protein histidine kinase activity
H70737_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS19480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS19485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS19490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS19495	COG0529	Catalyzes the synthesis of activated sulfate
H70737_RS19530	COG1368	sulfuric ester hydrolase activity
H70737_RS19535	COG1879	ABC-type sugar transport system periplasmic component
H70737_RS19540	COG1172	Belongs to the binding-protein-dependent transport system permease family
H70737_RS19545	COG1129	ABC transporter
H70737_RS19550	COG1869	D-ribose catabolic process
H70737_RS19555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H70737_RS19560	COG1609	Transcriptional regulator
H70737_RS19580	COG1132	(ABC) transporter
H70737_RS19585	COG1132	(ABC) transporter
H70737_RS19635	COG1136	(ABC) transporter
H70737_RS19685	COG1785	Belongs to the alkaline phosphatase family
H70737_RS19710	COG0431	NADPH-dependent FMN reductase
H70737_RS19720	COG0346	lactoylglutathione lyase activity
H70737_RS19755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H70737_RS19760	COG4608	Belongs to the ABC transporter superfamily
H70737_RS19765	COG0444	Belongs to the ABC transporter superfamily
H70737_RS19770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H70737_RS19775	COG0601	transmembrane transport
H70737_RS19795	COG1285	pathogenesis
H70737_RS19800	COG2070	2-Nitropropane dioxygenase
H70737_RS19825	COG0577	efflux transmembrane transporter activity
H70737_RS19825	COG1136	(ABC) transporter
H70737_RS19830	COG5002	protein histidine kinase activity
H70737_RS19835	COG0745	RESPONSE REGULATOR receiver
H70737_RS19865	COG1132	(ABC) transporter
H70737_RS19910	COG1316	TRANSCRIPTIONal
H70737_RS19920	COG1278	Cold shock
H70737_RS19925	COG0840	transmembrane signaling receptor activity
H70737_RS19930	COG0517	IMP dehydrogenase activity
H70737_RS19930	COG0516	GMP reductase activity
H70737_RS19935	COG0024	Methionine aminopeptidase
H70737_RS19940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H70737_RS19945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H70737_RS19955	COG0745	RESPONSE REGULATOR receiver
H70737_RS19970	COG2848	UPF0210 protein
H70737_RS19985	COG3754	Rhamnan synthesis protein F
H70737_RS19990	COG2814	Major facilitator Superfamily
H70737_RS19995	COG1846	Transcriptional regulator
H70737_RS20005	COG2197	response regulator
H70737_RS20010	COG2972	Histidine kinase
H70737_RS20020	COG0395	ABC-type sugar transport system, permease component
H70737_RS20025	COG4209	transmembrane transport
H70737_RS20030	COG2814	Major facilitator Superfamily
H70737_RS20040	COG1664	Polymer-forming cytoskeletal
H70737_RS20045	COG0789	Transcriptional regulator
H70737_RS20055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H70737_RS20060	COG4608	Belongs to the ABC transporter superfamily
H70737_RS20065	COG0444	Belongs to the ABC transporter superfamily
H70737_RS20070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H70737_RS20075	COG0601	transmembrane transport
H70737_RS20080	COG0747	negative chemotaxis
H70737_RS20090	COG2388	GCN5-related N-acetyl-transferase
H70737_RS20105	COG0716	FMN binding
H70737_RS20120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H70737_RS20120	COG0116	Belongs to the methyltransferase superfamily
H70737_RS20125	COG0564	pseudouridine synthase activity
H70737_RS20130	COG1846	Transcriptional regulator
H70737_RS20135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H70737_RS20145	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H70737_RS20150	COG1131	(ABC) transporter
H70737_RS20160	COG2340	Cysteine-rich secretory protein family
H70737_RS20175	COG4211	Belongs to the binding-protein-dependent transport system permease family
H70737_RS20195	COG2972	Histidine kinase
H70737_RS20200	COG2207	Transcriptional regulator
H70737_RS20200	COG4753	response regulator
H70737_RS20205	COG0456	acetyltransferase
H70737_RS20210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H70737_RS20215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H70737_RS20225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H70737_RS20240	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS20245	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS20245	COG2247	cell wall binding repeat
H70737_RS20250	COG0066	3-isopropylmalate dehydratase activity
H70737_RS20255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H70737_RS20260	COG0277	FAD linked oxidase domain protein
H70737_RS20265	COG0583	DNA-binding transcription factor activity
H70737_RS20275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H70737_RS20300	COG1595	DNA-templated transcription, initiation
H70737_RS20305	COG3935	DnaD domain protein
H70737_RS20310	COG0017	Asparaginyl-tRNA synthetase
H70737_RS20315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H70737_RS20320	COG1250	3-hydroxyacyl-CoA dehydrogenase
H70737_RS20325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H70737_RS20340	COG0402	S-adenosylhomocysteine deaminase activity
H70737_RS20345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H70737_RS20350	COG1199	ATP-dependent helicase activity
H70737_RS20350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H70737_RS20360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H70737_RS20365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H70737_RS20370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H70737_RS20385	COG0438	transferase activity, transferring glycosyl groups
H70737_RS20390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H70737_RS20395	COG1803	Methylglyoxal synthase
H70737_RS20400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H70737_RS20410	COG1694	Mazg nucleotide pyrophosphohydrolase
H70737_RS20415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS20425	COG4347	Protein of unknown function (DUF1405)
H70737_RS20475	COG1396	sequence-specific DNA binding
H70737_RS20480	COG2807	transmembrane transport
H70737_RS20485	COG0287	Prephenate dehydrogenase
H70737_RS20490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H70737_RS20495	COG0159	tryptophan synthase activity
H70737_RS20500	COG0133	tryptophan synthase activity
H70737_RS20505	COG0135	phosphoribosylanthranilate isomerase activity
H70737_RS20510	COG0134	indole-3-glycerol-phosphate synthase activity
H70737_RS20515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H70737_RS20525	COG4401	Chorismate mutase type I
H70737_RS20530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H70737_RS20535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H70737_RS20540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H70737_RS20545	COG0105	UTP biosynthetic process
H70737_RS20560	COG0163	prenyltransferase activity
H70737_RS20570	COG2226	methyltransferase
H70737_RS20595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H70737_RS20625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H70737_RS20630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H70737_RS20635	COG1160	GTP binding
H70737_RS20645	COG0204	Acyl-transferase
H70737_RS20650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H70737_RS20660	COG2959	enzyme of heme biosynthesis
H70737_RS20670	COG2339	peptidase activity
H70737_RS20675	COG4862	establishment of competence for transformation
H70737_RS20685	COG0726	polysaccharide deacetylase
H70737_RS20690	COG1408	metallophosphoesterase
H70737_RS20710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H70737_RS20730	COG0028	Belongs to the TPP enzyme family
H70737_RS20760	COG5002	protein histidine kinase activity
H70737_RS20760	COG5002	protein histidine kinase activity
H70737_RS20765	COG0745	RESPONSE REGULATOR receiver
H70737_RS20770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H70737_RS20775	COG1333	cytochrome c biogenesis protein
H70737_RS20780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H70737_RS20785	COG1187	pseudouridine synthase activity
H70737_RS20795	COG0700	Nucleoside recognition
H70737_RS20800	COG2715	membrane protein required for spore maturation
H70737_RS20805	COG1686	Belongs to the peptidase S11 family
H70737_RS20810	COG3874	Sporulation protein YtfJ
H70737_RS20820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H70737_RS20825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H70737_RS20830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H70737_RS20835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H70737_RS20835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H70737_RS20840	COG0307	riboflavin synthase, alpha
H70737_RS20845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H70737_RS20845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H70737_RS20855	COG5002	protein histidine kinase activity
H70737_RS20865	COG5522	Integral membrane protein (intg_mem_TP0381)
H70737_RS20870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H70737_RS20875	COG0019	diaminopimelate decarboxylase activity
H70737_RS20880	COG0697	spore germination
H70737_RS20905	COG0395	ABC-type sugar transport system, permease component
H70737_RS20910	COG4209	transmembrane transport
H70737_RS20920	COG2207	Transcriptional regulator
H70737_RS20925	COG3275	phosphorelay sensor kinase activity
H70737_RS20935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H70737_RS20940	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS20950	COG2272	Belongs to the type-B carboxylesterase lipase family
H70737_RS20955	COG0628	permease
H70737_RS20970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS20975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS20980	COG4977	sequence-specific DNA binding
H70737_RS20980	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS20990	COG1132	(ABC) transporter
H70737_RS20995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS21000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H70737_RS21005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS21015	COG0577	efflux transmembrane transporter activity
H70737_RS21020	COG1136	(ABC) transporter
H70737_RS21025	COG0477	Major facilitator Superfamily
H70737_RS21035	COG2201	protein-glutamate methylesterase activity
H70737_RS21040	COG0840	transmembrane signaling receptor activity
H70737_RS21045	COG2197	response regulator
H70737_RS21060	COG2172	sigma factor antagonist activity
H70737_RS21065	COG1366	Belongs to the anti-sigma-factor antagonist family
H70737_RS21070	COG1686	Belongs to the peptidase S11 family
H70737_RS21075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H70737_RS21090	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H70737_RS21095	COG4974	Belongs to the 'phage' integrase family
H70737_RS21105	COG0735	belongs to the Fur family
H70737_RS21110	COG1300	Membrane
H70737_RS21115	COG1379	DNA repair
H70737_RS21125	COG2195	Cleaves the N-terminal amino acid of tripeptides
H70737_RS21130	COG0321	lipoyl(octanoyl) transferase activity
H70737_RS21135	COG0508	dehydrogenase complex catalyzes the overall conversion of
H70737_RS21140	COG0022	dehydrogenase e1 component
H70737_RS21145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H70737_RS21150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H70737_RS21160	COG1132	(ABC) transporter
H70737_RS21165	COG1132	(ABC) transporter
H70737_RS21235	COG0488	(ABC) transporter
H70737_RS21245	COG0745	RESPONSE REGULATOR receiver
H70737_RS21250	COG0750	zinc metalloprotease
H70737_RS21255	COG0497	DNA recombination
H70737_RS21270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H70737_RS21275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H70737_RS21285	COG1722	exodeoxyribonuclease VII activity
H70737_RS21290	COG1570	exodeoxyribonuclease VII activity
H70737_RS21295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H70737_RS21300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H70737_RS21315	COG1302	Protein conserved in bacteria
H70737_RS21320	COG0439	Biotin carboxylase
H70737_RS21325	COG0511	ligase activity, forming carbon-carbon bonds
H70737_RS21365	COG3854	ATPases associated with a variety of cellular activities
H70737_RS21375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS21385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H70737_RS21390	COG0006	proline dipeptidase activity
H70737_RS21400	COG3872	metal-dependent enzyme
H70737_RS21410	COG1752	Esterase of the alpha-beta hydrolase superfamily
H70737_RS21415	COG1649	PFAM Uncharacterised BCR, COG1649
H70737_RS21420	COG1321	iron dependent repressor
H70737_RS21425	COG1533	DNA photolyase activity
H70737_RS21430	COG0785	Cytochrome C biogenesis protein
H70737_RS21435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H70737_RS21440	COG1121	(ABC) transporter
H70737_RS21445	COG0803	Belongs to the bacterial solute-binding protein 9 family
H70737_RS21445	COG3443	Belongs to the bacterial solute-binding protein 9 family
H70737_RS21450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H70737_RS21450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H70737_RS21455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H70737_RS21460	COG0735	belongs to the Fur family
H70737_RS21470	COG3275	phosphorelay sensor kinase activity
H70737_RS21475	COG2207	Transcriptional regulator
H70737_RS21475	COG4753	response regulator
H70737_RS21485	COG1653	transport
H70737_RS21490	COG0395	ABC-type sugar transport system, permease component
H70737_RS21495	COG4209	transmembrane transport
H70737_RS21500	COG4753	response regulator
H70737_RS21500	COG2207	Transcriptional regulator
H70737_RS21505	COG2972	Histidine kinase
H70737_RS21510	COG0395	ABC-type sugar transport system, permease component
H70737_RS21515	COG1175	transmembrane transport
H70737_RS21520	COG1653	transport
H70737_RS21525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H70737_RS21535	COG1012	belongs to the aldehyde dehydrogenase family
H70737_RS21535	COG1454	alcohol dehydrogenase
H70737_RS21545	COG0395	ABC-type sugar transport system, permease component
H70737_RS21550	COG1175	transmembrane transport
H70737_RS21555	COG2204	response regulator
H70737_RS21560	COG2972	Histidine kinase
H70737_RS21570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H70737_RS21575	COG1554	hydrolase, family 65, central catalytic
H70737_RS21585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H70737_RS21595	COG2146	nitrite reductase [NAD(P)H] activity
H70737_RS21600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H70737_RS21615	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H70737_RS21625	COG1733	regulation of RNA biosynthetic process
H70737_RS21635	COG0673	inositol 2-dehydrogenase activity
H70737_RS21645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H70737_RS21645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H70737_RS21660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H70737_RS21665	COG1968	undecaprenyl-diphosphatase activity
H70737_RS21670	COG0586	Pfam SNARE associated Golgi protein
H70737_RS21675	COG0577	efflux transmembrane transporter activity
H70737_RS21680	COG1136	(ABC) transporter
H70737_RS21685	COG2205	protein histidine kinase activity
H70737_RS21690	COG0745	RESPONSE REGULATOR receiver
H70737_RS21705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS21710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H70737_RS21715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H70737_RS21715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H70737_RS21715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H70737_RS21720	COG1105	Belongs to the carbohydrate kinase PfkB family
H70737_RS21725	COG1349	DNA-binding transcription factor activity
H70737_RS21735	COG0628	permease
H70737_RS21745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H70737_RS21750	COG0328	RNA-DNA hybrid ribonuclease activity
H70737_RS21750	COG3341	Caulimovirus viroplasmin
H70737_RS21760	COG0693	protein deglycase activity
H70737_RS21765	COG4335	DNA alkylation repair
H70737_RS21790	COG3623	hexulose-6-phosphate isomerase
H70737_RS21800	COG5426	von Willebrand factor, type A
H70737_RS21805	COG0395	ABC-type sugar transport system, permease component
H70737_RS21810	COG1175	transmembrane transport
H70737_RS21815	COG1653	transport
H70737_RS21820	COG2972	Histidine kinase
H70737_RS21825	COG4753	response regulator
H70737_RS21825	COG2207	Transcriptional regulator
H70737_RS21830	COG2318	DinB family
H70737_RS21845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H70737_RS21855	COG4555	ABC transporter
H70737_RS21880	COG0583	DNA-binding transcription factor activity
H70737_RS21885	COG0477	Major facilitator Superfamily
H70737_RS21915	COG1131	(ABC) transporter
H70737_RS21920	COG0745	RESPONSE REGULATOR receiver
H70737_RS21925	COG5002	protein histidine kinase activity
H70737_RS21940	COG0745	RESPONSE REGULATOR receiver
H70737_RS21945	COG1063	alcohol dehydrogenase
H70737_RS21955	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
H70737_RS21965	COG0366	Alpha amylase catalytic
H70737_RS21970	COG0395	ABC-type sugar transport system, permease component
H70737_RS21975	COG1175	transmembrane transport
H70737_RS21980	COG1653	transport
H70737_RS21985	COG1609	Transcriptional regulator
H70737_RS22000	COG4753	response regulator
H70737_RS22000	COG2207	Transcriptional regulator
H70737_RS22005	COG2972	Histidine kinase
H70737_RS22015	COG0395	ABC-type sugar transport system, permease component
H70737_RS22020	COG1175	transmembrane transport
H70737_RS22025	COG0534	Mate efflux family protein
H70737_RS22030	COG1846	Transcriptional regulator
H70737_RS22045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H70737_RS22055	COG4977	sequence-specific DNA binding
H70737_RS22055	COG1917	Cupin 2, conserved barrel domain protein
H70737_RS22070	COG2207	Transcriptional regulator
H70737_RS22080	COG0395	ABC-type sugar transport system, permease component
H70737_RS22085	COG4209	transmembrane transport
H70737_RS22090	COG2972	Histidine kinase
H70737_RS22105	COG3279	Response regulator of the LytR AlgR family
H70737_RS22130	COG5434	Belongs to the glycosyl hydrolase 28 family
H70737_RS22145	COG0395	ABC-type sugar transport system, permease component
H70737_RS22150	COG4209	transmembrane transport
H70737_RS22180	COG2801	Transposase and inactivated derivatives
H70737_RS22200	COG3706	GGDEF domain
H70737_RS22215	COG1876	peptidase activity
H70737_RS22235	COG5183	chlorophyll binding
H70737_RS22235	COG2133	pyrroloquinoline quinone binding
H70737_RS22245	COG3209	COG3209 Rhs family protein
H70737_RS22250	COG2856	Zn peptidase
H70737_RS22290	COG0582	viral genome integration into host DNA
H70737_RS22310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H70737_RS22315	COG0284	orotidine-5'-phosphate decarboxylase activity
H70737_RS22320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H70737_RS22325	COG0505	Belongs to the CarA family
H70737_RS22330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H70737_RS22335	COG0540	Belongs to the ATCase OTCase family
H70737_RS22340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H70737_RS22345	COG0436	Aminotransferase
H70737_RS22350	COG0564	pseudouridine synthase activity
H70737_RS22355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H70737_RS22360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H70737_RS22380	COG3599	regulation of cell shape
H70737_RS22385	COG2302	S4 RNA-binding domain
H70737_RS22395	COG1799	cell septum assembly
H70737_RS22400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H70737_RS22405	COG1496	oxidoreductase activity
H70737_RS22410	COG1873	PFAM PRC-barrel domain
H70737_RS22415	COG1191	sigma factor activity
H70737_RS22420	COG1191	sigma factor activity
H70737_RS22430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H70737_RS22435	COG0849	cell division
H70737_RS22440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H70737_RS22445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H70737_RS22450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H70737_RS22455	COG0772	Belongs to the SEDS family
H70737_RS22460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H70737_RS22465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H70737_RS22470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H70737_RS22475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H70737_RS22480	COG0768	penicillin binding
H70737_RS22485	COG0768	penicillin binding
H70737_RS22495	COG0275	rRNA processing
H70737_RS22500	COG2001	Belongs to the MraZ family
H70737_RS22505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H70737_RS22510	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H70737_RS22515	COG4608	Belongs to the ABC transporter superfamily
H70737_RS22520	COG0444	Belongs to the ABC transporter superfamily
H70737_RS22525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H70737_RS22530	COG0601	transmembrane transport
H70737_RS22535	COG4166	transmembrane transport
H70737_RS22545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H70737_RS22570	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H70737_RS22585	COG1316	TRANSCRIPTIONal
H70737_RS22595	COG1217	gtp-binding protein TYPA
H70737_RS22605	COG0861	Integral membrane protein TerC family
H70737_RS22610	COG0861	Integral membrane protein TerC family
H70737_RS22615	COG0301	tRNA thio-modification
H70737_RS22620	COG1104	cysteine desulfurase activity
H70737_RS22630	COG4709	membrane
H70737_RS22650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS22655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS22660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H70737_RS22665	COG2384	SAM-dependent methyltransferase
H70737_RS22680	COG0358	DNA primase activity
H70737_RS22685	COG1671	Belongs to the UPF0178 family
H70737_RS22690	COG0751	glycine-tRNA ligase activity
H70737_RS22695	COG0752	glycyl-tRNA synthetase alpha subunit
H70737_RS22700	COG1381	Involved in DNA repair and RecF pathway recombination
H70737_RS22705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H70737_RS22715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H70737_RS22720	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H70737_RS22725	COG1480	7TM receptor with intracellular HD hydrolase
H70737_RS22730	COG1702	phosphate starvation-inducible protein PhoH
H70737_RS22750	COG4864	UPF0365 protein
H70737_RS22755	COG1030	water channel activity
H70737_RS22760	COG1610	YqeY-like protein
H70737_RS22765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H70737_RS22770	COG0537	adenosine 5'-monophosphoramidase activity
H70737_RS22775	COG0419	ATPase involved in DNA repair
H70737_RS22780	COG0420	3'-5' exonuclease activity
H70737_RS22790	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H70737_RS22810	COG1283	sodium-dependent phosphate transmembrane transporter activity
H70737_RS22815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H70737_RS22825	COG4720	Psort location CytoplasmicMembrane, score
H70737_RS22845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H70737_RS22850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H70737_RS22855	COG1994	Peptidase M50
H70737_RS22860	COG2264	protein methyltransferase activity
H70737_RS22865	COG0519	Catalyzes the synthesis of GMP from XMP
H70737_RS22875	COG1595	DNA-templated transcription, initiation
H70737_RS22920	COG1420	regulation of RNA biosynthetic process
H70737_RS22930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H70737_RS22935	COG0445	tRNA wobble uridine modification
H70737_RS22940	COG0395	ABC-type sugar transport system, permease component
H70737_RS22955	COG2204	response regulator
H70737_RS22965	COG0481	GTPase activity
H70737_RS22985	COG0268	Binds directly to 16S ribosomal RNA
H70737_RS22990	COG1466	dna polymerase III delta subunit
H70737_RS23000	COG1595	DNA-templated transcription, initiation
H70737_RS23010	COG0800	Aldolase
H70737_RS23015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H70737_RS23020	COG1609	Transcriptional regulator
H70737_RS23035	COG0658	competence protein
H70737_RS23035	COG2333	competence protein COMEC
H70737_RS23050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H70737_RS23055	COG0495	leucyl-tRNA aminoacylation
H70737_RS23060	COG0628	permease
H70737_RS23075	COG1104	cysteine desulfurase activity
H70737_RS23080	COG1683	Conserved Protein
H70737_RS23085	COG2135	peptidase activity
H70737_RS23095	COG1216	Glycosyl transferase, family 2
H70737_RS23115	COG1959	2 iron, 2 sulfur cluster binding
H70737_RS23120	COG0482	sulfurtransferase activity
H70737_RS23135	COG0601	transmembrane transport
H70737_RS23140	COG4608	Belongs to the ABC transporter superfamily
H70737_RS23150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H70737_RS23155	COG5566	PFAM Mor transcription activator
H70737_RS23160	COG3973	AAA domain
H70737_RS23170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H70737_RS23175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H70737_RS23180	COG0124	histidyl-tRNA synthetase
H70737_RS23190	COG0693	protein deglycase activity
H70737_RS23200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H70737_RS23205	COG2233	PERMEase
H70737_RS23210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H70737_RS23215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H70737_RS23215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H70737_RS23225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H70737_RS23225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H70737_RS23230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H70737_RS23230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H70737_RS23240	COG2244	polysaccharide biosynthetic process
H70737_RS23245	COG2323	membrane
H70737_RS23260	COG1862	Preprotein translocase
H70737_RS23270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H70737_RS23275	COG2385	sporulation resulting in formation of a cellular spore
H70737_RS23280	COG2255	four-way junction helicase activity
H70737_RS23285	COG0632	four-way junction helicase activity
H70737_RS23290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H70737_RS23310	COG2423	ornithine cyclodeaminase activity
H70737_RS23315	COG0667	Aldo Keto reductase
H70737_RS23320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H70737_RS23325	COG4989	oxidoreductase activity
H70737_RS23375	COG1660	Displays ATPase and GTPase activities
H70737_RS23400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H70737_RS23405	COG0077	Prephenate dehydratase
H70737_RS23410	COG0083	homoserine kinase activity
H70737_RS23415	COG0460	homoserine dehydrogenase
H70737_RS23420	COG4492	Belongs to the UPF0735 family
H70737_RS23445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H70737_RS23455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H70737_RS23460	COG2868	ribosomal protein
H70737_RS23465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H70737_RS23475	COG1994	Peptidase M50
H70737_RS23485	COG2894	cell division
H70737_RS23490	COG0850	regulation of cytokinetic process
H70737_RS23500	COG1792	Involved in formation and maintenance of cell shape
H70737_RS23505	COG1077	Cell shape determining protein MreB Mrl
H70737_RS23510	COG2003	Belongs to the UPF0758 family
H70737_RS23515	COG0424	maF-like protein
H70737_RS23540	COG3706	GGDEF domain
H70737_RS23545	COG3706	GGDEF domain
H70737_RS23550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H70737_RS23555	COG0285	dihydrofolate synthase activity
H70737_RS23560	COG0525	valine-tRNA ligase activity
H70737_RS23565	COG1388	LysM domain
H70737_RS23570	COG0564	pseudouridine synthase activity
H70737_RS23575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H70737_RS23580	COG0113	porphobilinogen synthase activity
H70737_RS23595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H70737_RS23595	COG1648	precorrin-2 dehydrogenase activity
H70737_RS23625	COG1086	Polysaccharide biosynthesis protein
H70737_RS23645	COG0438	transferase activity, transferring glycosyl groups
H70737_RS23665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H70737_RS23700	COG0489	protein tyrosine kinase activity
H70737_RS23705	COG3944	biosynthesis protein
H70737_RS23715	COG4464	protein tyrosine phosphatase activity
H70737_RS23720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H70737_RS23730	COG0470	DNA polymerase III
H70737_RS23730	COG1067	ATP-dependent peptidase activity
H70737_RS23740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H70737_RS23745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H70737_RS23750	COG0740	serine-type endopeptidase activity
H70737_RS23755	COG0544	peptidyl-prolyl cis-trans isomerase activity
H70737_RS23770	COG0581	inorganic phosphate transmembrane transporter activity
H70737_RS23775	COG0573	inorganic phosphate transmembrane transporter activity
H70737_RS23790	COG0246	Mannitol dehydrogenase
H70737_RS23795	COG1312	Catalyzes the dehydration of D-mannonate
H70737_RS23805	COG1063	alcohol dehydrogenase
H70737_RS23810	COG3250	beta-galactosidase activity
H70737_RS23825	COG1131	(ABC) transporter
H70737_RS23830	COG0842	Transport permease protein
H70737_RS23830	COG1511	domain protein
H70737_RS23835	COG1309	transcriptional regulator
H70737_RS23860	COG0018	arginyl-trna synthetase
H70737_RS23865	COG3459	Glycosyltransferase 36 associated
H70737_RS23870	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS23900	COG0367	asparagine synthase
H70737_RS23905	COG0656	L-ascorbic acid biosynthetic process
H70737_RS23935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H70737_RS23940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H70737_RS23950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H70737_RS23955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS23965	COG0366	Alpha amylase catalytic
H70737_RS23970	COG2207	Transcriptional regulator
H70737_RS23970	COG4753	response regulator
H70737_RS23980	COG1653	transport
H70737_RS23985	COG1175	transmembrane transport
H70737_RS23995	COG0861	Integral membrane protein TerC family
H70737_RS24015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS24030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS24035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H70737_RS24040	COG1687	branched-chain amino acid
H70737_RS24050	COG2188	Transcriptional regulator
H70737_RS24070	COG3964	amidohydrolase
H70737_RS24075	COG2731	YhcH YjgK YiaL family protein
H70737_RS24080	COG1737	Transcriptional regulator
H70737_RS24090	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H70737_RS24095	COG0395	ABC-type sugar transport system, permease component
H70737_RS24100	COG1175	transmembrane transport
H70737_RS24115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H70737_RS24130	COG2207	Transcriptional regulator
H70737_RS24130	COG4753	response regulator
H70737_RS24135	COG2972	Histidine kinase
H70737_RS24140	COG0395	ABC-type sugar transport system, permease component
H70737_RS24145	COG4209	transmembrane transport
H70737_RS24165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H70737_RS24185	COG3708	Transcriptional regulator
H70737_RS24185	COG2207	Transcriptional regulator
H70737_RS24205	COG3279	Response regulator of the LytR AlgR family
H70737_RS24210	COG2323	membrane
H70737_RS24220	COG0189	ligase activity
H70737_RS24245	COG0604	alcohol dehydrogenase
H70737_RS24250	COG0640	Transcriptional regulator
H70737_RS24260	COG1595	DNA-templated transcription, initiation
H70737_RS24270	COG1132	(ABC) transporter
H70737_RS24275	COG2375	cellular response to nickel ion
H70737_RS24275	COG1132	(ABC) transporter
H70737_RS24305	COG0395	ABC-type sugar transport system, permease component
H70737_RS24310	COG4209	transmembrane transport
H70737_RS24315	COG1486	melibiose metabolic process
H70737_RS24330	COG2197	response regulator
H70737_RS24335	COG2822	iron ion transport
H70737_RS24340	COG2837	iron assimilation
H70737_RS24345	COG0672	)-iron permease
H70737_RS24350	COG1609	Transcriptional regulator
H70737_RS24355	COG1737	Transcriptional regulator
H70737_RS24385	COG0463	Glycosyl transferase, family 2
H70737_RS24385	COG1216	Glycosyl transferase, family 2
H70737_RS24400	COG1088	dTDP-glucose 4,6-dehydratase activity
H70737_RS24410	COG1086	Polysaccharide biosynthesis protein
H70737_RS24425	COG0438	transferase activity, transferring glycosyl groups
H70737_RS24430	COG4641	Protein conserved in bacteria
H70737_RS24430	COG1388	LysM domain
H70737_RS24450	COG1368	sulfuric ester hydrolase activity
H70737_RS24455	COG0402	S-adenosylhomocysteine deaminase activity
H70737_RS24495	COG4977	sequence-specific DNA binding
H70737_RS24500	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H70737_RS24505	COG0463	Glycosyl transferase, family 2
H70737_RS24525	COG0189	ligase activity
H70737_RS24530	COG0688	phosphatidylethanolamine metabolic process
H70737_RS24540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H70737_RS24545	COG0588	phosphoglycerate mutase activity
H70737_RS24575	COG1131	(ABC) transporter
H70737_RS24585	COG0300	oxidoreductase activity
H70737_RS24595	COG0583	DNA-binding transcription factor activity
H70737_RS24600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H70737_RS24605	COG0778	Nitroreductase
H70737_RS24615	COG1408	metallophosphoesterase
H70737_RS24625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H70737_RS24630	COG1053	succinate dehydrogenase
H70737_RS24635	COG2009	succinate dehydrogenase
H70737_RS24640	COG0583	DNA-binding transcription factor activity
H70737_RS24645	COG0569	domain protein
H70737_RS24650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H70737_RS24660	COG0322	excinuclease ABC activity
H70737_RS24665	COG3118	belongs to the thioredoxin family
H70737_RS24670	COG1484	DNA-dependent DNA replication
H70737_RS24685	COG3253	May function as heme-dependent peroxidase
H70737_RS24695	COG1252	NADH dehydrogenase
H70737_RS24700	COG0492	ferredoxin-NADP+ reductase activity
H70737_RS24705	COG0189	ligase activity
H70737_RS24715	COG0456	acetyltransferase
H70737_RS24720	COG0316	Belongs to the HesB IscA family
H70737_RS24725	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H70737_RS24730	COG1252	NADH dehydrogenase
H70737_RS24735	COG4844	belongs to the
H70737_RS24740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H70737_RS24745	COG1464	Belongs to the NlpA lipoprotein family
H70737_RS24750	COG2011	ABC-type metal ion transport system permease component
H70737_RS24755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H70737_RS24765	COG1612	heme a metabolic process
H70737_RS24770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H70737_RS24775	COG2244	polysaccharide biosynthetic process
H70737_RS24780	COG2839	Protein conserved in bacteria
H70737_RS24785	COG0561	phosphatase activity
H70737_RS24790	COG0768	penicillin binding
H70737_RS24795	COG0768	penicillin binding
H70737_RS24815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H70737_RS24825	COG0109	protoheme IX farnesyltransferase activity
H70737_RS24830	COG1988	membrane-bound metal-dependent
H70737_RS24840	COG0180	Tryptophanyl-tRNA synthetase
H70737_RS24865	COG3093	addiction module antidote protein HigA
H70737_RS24880	COG2346	COG2346, Truncated hemoglobins
H70737_RS24885	COG3314	Sporulation integral membrane protein YlbJ
H70737_RS24890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H70737_RS24900	COG0793	Belongs to the peptidase S41A family
H70737_RS24900	COG3409	Peptidoglycan-binding domain 1 protein
H70737_RS24915	COG0739	heme binding
H70737_RS24965	COG0463	Glycosyl transferase, family 2
H70737_RS24965	COG0457	Tetratricopeptide repeat
H70737_RS25010	COG4175	Glycine betaine
H70737_RS25010	COG0517	IMP dehydrogenase activity
H70737_RS25015	COG1510	regulation of RNA biosynthetic process
H70737_RS25035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H70737_RS25045	COG0534	Mate efflux family protein
H70737_RS25060	COG3833	ABC-type maltose transport systems, permease component
H70737_RS25065	COG4209	transmembrane transport
H70737_RS25070	COG2207	Transcriptional regulator
H70737_RS25070	COG1609	Transcriptional regulator
H70737_RS25080	COG1104	cysteine desulfurase activity
H70737_RS25085	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H70737_RS25090	COG0709	Synthesizes selenophosphate from selenide and ATP
H70737_RS25095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H70737_RS25115	COG0395	ABC-type sugar transport system, permease component
H70737_RS25120	COG4209	transmembrane transport
H70737_RS25125	COG1653	transport
H70737_RS25135	COG3275	phosphorelay sensor kinase activity
H70737_RS25145	COG2169	Transcriptional regulator
H70737_RS25145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H70737_RS25150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H70737_RS25175	COG3711	transcriptional antiterminator
H70737_RS25180	COG1263	PTS System
H70737_RS25180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H70737_RS25180	COG2190	(PTS) system
H70737_RS25195	COG0745	RESPONSE REGULATOR receiver
H70737_RS25200	COG5002	protein histidine kinase activity
H70737_RS25210	COG1132	(ABC) transporter
H70737_RS25215	COG1132	(ABC) transporter
H70737_RS25220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H70737_RS25225	COG0569	domain protein
H70737_RS25235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H70737_RS25240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H70737_RS25245	COG0697	spore germination
H70737_RS25250	COG0531	amino acid
H70737_RS25265	COG2197	response regulator
H70737_RS25270	COG4585	Histidine kinase
H70737_RS25280	COG1842	Phage shock protein A
H70737_RS25300	COG2205	protein histidine kinase activity
H70737_RS25305	COG0745	RESPONSE REGULATOR receiver
H70737_RS25315	COG1136	(ABC) transporter
H70737_RS25315	COG0577	efflux transmembrane transporter activity
H70737_RS25325	COG2011	ABC-type metal ion transport system permease component
H70737_RS25330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H70737_RS25340	COG1957	nucleoside hydrolase
H70737_RS25345	COG1079	Belongs to the binding-protein-dependent transport system permease family
H70737_RS25350	COG4603	Belongs to the binding-protein-dependent transport system permease family
H70737_RS25355	COG3845	ABC transporter
H70737_RS25360	COG1744	ABC transporter substrate-binding protein PnrA-like
H70737_RS25470	COG3858	chitin binding
H70737_RS25475	COG0735	belongs to the Fur family
H70737_RS25485	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H70737_RS25485	COG0456	acetyltransferase
H70737_RS25490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H70737_RS25495	COG0154	amidase activity
H70737_RS25500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H70737_RS25510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H70737_RS25515	COG1131	(ABC) transporter
H70737_RS25535	COG1595	DNA-templated transcription, initiation
H70737_RS25545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H70737_RS25555	COG0586	Pfam SNARE associated Golgi protein
H70737_RS25560	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS25565	COG0640	Transcriptional regulator
H70737_RS25585	COG0384	phenazine biosynthesis protein PhzF
H70737_RS25595	COG2267	carboxylic ester hydrolase activity
H70737_RS25615	COG3833	ABC-type maltose transport systems, permease component
H70737_RS25620	COG1175	transmembrane transport
H70737_RS25625	COG2182	Extracellular solute-binding protein
H70737_RS25645	COG1191	sigma factor activity
H70737_RS25655	COG1366	Belongs to the anti-sigma-factor antagonist family
H70737_RS25665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H70737_RS25670	COG2205	protein histidine kinase activity
H70737_RS25670	COG3437	response regulator, receiver
H70737_RS25670	COG3850	Histidine kinase
H70737_RS25670	COG4999	Histidine kinase
H70737_RS25675	COG2208	phosphoserine phosphatase activity
H70737_RS25705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H70737_RS25720	COG0488	(ABC) transporter
H70737_RS25730	COG1413	lyase activity
H70737_RS25735	COG0833	amino acid
H70737_RS25755	COG0395	ABC-type sugar transport system, permease component
H70737_RS25760	COG4209	transmembrane transport
H70737_RS25765	COG4753	response regulator
H70737_RS25765	COG2207	Transcriptional regulator
H70737_RS25770	COG2972	Histidine kinase
H70737_RS25775	COG1070	Carbohydrate kinase
H70737_RS25805	COG2217	Heavy metal translocating P-type atpase
H70737_RS25820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H70737_RS25835	COG0330	HflC and HflK could
H70737_RS25845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS25855	COG0659	secondary active sulfate transmembrane transporter activity
H70737_RS25860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H70737_RS25860	COG1605	Chorismate mutase
H70737_RS25865	COG0386	Belongs to the glutathione peroxidase family
H70737_RS25875	COG1053	succinate dehydrogenase
H70737_RS25895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS25900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS25905	COG1116	anion transmembrane transporter activity
H70737_RS25935	COG3103	Sh3 type 3 domain protein
H70737_RS25935	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS25935	COG4991	sh3 domain protein
H70737_RS25940	COG1732	Glycine betaine
H70737_RS25945	COG1174	glycine betaine transport
H70737_RS25960	COG1914	H( )-stimulated, divalent metal cation uptake system
H70737_RS25985	COG2140	Oxalate decarboxylase
H70737_RS25990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H70737_RS25995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H70737_RS26000	COG0640	Transcriptional regulator
H70737_RS26005	COG5002	protein histidine kinase activity
H70737_RS26010	COG0745	RESPONSE REGULATOR receiver
H70737_RS26025	COG2197	response regulator
H70737_RS26030	COG4585	Histidine kinase
H70737_RS26060	COG1131	(ABC) transporter
H70737_RS26070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H70737_RS26070	COG3321	synthase
H70737_RS26070	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS26070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H70737_RS26070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H70737_RS26085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H70737_RS26095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H70737_RS26110	COG4846	Membrane protein involved in cytochrome C biogenesis
H70737_RS26115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H70737_RS26120	COG0840	transmembrane signaling receptor activity
H70737_RS26130	COG2217	Heavy metal translocating P-type atpase
H70737_RS26155	COG0813	purine-nucleoside phosphorylase activity
H70737_RS26170	COG0450	alkyl hydroperoxide reductase
H70737_RS26185	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H70737_RS26190	COG1874	Beta-galactosidase
H70737_RS26190	COG0366	Alpha amylase catalytic
H70737_RS26220	COG1335	isochorismatase
H70737_RS26225	COG0492	ferredoxin-NADP+ reductase activity
H70737_RS26230	COG0656	L-ascorbic acid biosynthetic process
H70737_RS26235	COG1309	transcriptional regulator
H70737_RS26245	COG3833	ABC-type maltose transport systems, permease component
H70737_RS26270	COG2972	Histidine kinase
H70737_RS26275	COG5646	InterPro IPR014922
H70737_RS26280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H70737_RS26290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H70737_RS26300	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H70737_RS26305	COG5662	AntiSigma factor
H70737_RS26310	COG1595	DNA-templated transcription, initiation
H70737_RS26315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H70737_RS26320	COG0583	DNA-binding transcription factor activity
H70737_RS26325	COG3842	ATPase activity
H70737_RS26330	COG1840	ABC-type Fe3 transport system, periplasmic component
H70737_RS26335	COG1178	ABC-type Fe3 transport system permease component
H70737_RS26340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H70737_RS26350	COG1876	peptidase activity
H70737_RS26385	COG3778	Protein conserved in bacteria
H70737_RS26405	COG3299	homolog of phage Mu protein gp47
H70737_RS26410	COG3628	GPW Gp25 family protein
H70737_RS26465	COG1396	sequence-specific DNA binding
H70737_RS26575	COG0726	polysaccharide deacetylase
H70737_RS26580	COG2326	polyphosphate kinase activity
H70737_RS26585	COG2194	sulfuric ester hydrolase activity
H70737_RS26595	COG0489	protein tyrosine kinase activity
H70737_RS26600	COG0860	N-Acetylmuramoyl-L-alanine amidase
H70737_RS26605	COG2046	Belongs to the sulfate adenylyltransferase family
H70737_RS26610	COG0175	sulfate reduction
H70737_RS26615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H70737_RS26620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H70737_RS26625	COG0101	tRNA pseudouridine synthase activity
H70737_RS26630	COG0203	ribosomal protein L17
H70737_RS26635	COG0202	RNA polymerase activity
H70737_RS26640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H70737_RS26645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H70737_RS26650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H70737_RS26655	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H70737_RS26660	COG2163	COG2163 Ribosomal protein L14E L6E L27E
H70737_RS26665	COG0024	Methionine aminopeptidase
H70737_RS26670	COG0563	adenylate kinase activity
H70737_RS26675	COG0201	protein transport
H70737_RS26680	COG0200	Binds to the 23S rRNA
H70737_RS26685	COG1841	ribosomal large subunit assembly
H70737_RS26690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H70737_RS26695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H70737_RS26700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H70737_RS26705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H70737_RS26710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H70737_RS26715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H70737_RS26720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H70737_RS26725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H70737_RS26730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H70737_RS26735	COG0255	Belongs to the universal ribosomal protein uL29 family
H70737_RS26740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H70737_RS26745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H70737_RS26755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H70737_RS26760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H70737_RS26765	COG0089	rRNA binding
H70737_RS26770	COG0088	Forms part of the polypeptide exit tunnel
H70737_RS26775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H70737_RS26785	COG0840	transmembrane signaling receptor activity
H70737_RS26790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H70737_RS26795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H70737_RS26800	COG0049	tRNA binding
H70737_RS26805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H70737_RS26810	COG1358	cellular component organization or biogenesis
H70737_RS26815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H70737_RS26820	COG0085	RNA polymerase activity
H70737_RS26825	COG2813	Specifically methylates the guanine in position
H70737_RS26830	COG0222	ribosome binding
H70737_RS26835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H70737_RS26840	COG0081	regulation of translation
H70737_RS26845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H70737_RS26850	COG0250	Participates in transcription elongation, termination and antitermination
H70737_RS26855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H70737_RS26865	COG3688	RNA-binding protein containing a PIN domain
H70737_RS26870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H70737_RS26875	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H70737_RS26880	COG0215	cysteine-tRNA ligase activity
H70737_RS26885	COG1045	serine acetyltransferase
H70737_RS26890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H70737_RS26895	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H70737_RS26900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H70737_RS26905	COG4956	integral membrane protein (PIN domain superfamily)
H70737_RS26910	COG1183	phosphatidylcholine synthase activity
H70737_RS26915	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H70737_RS26920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H70737_RS26925	COG0542	response to heat
H70737_RS26930	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H70737_RS26935	COG3880	PFAM UvrB UvrC protein
H70737_RS26970	COG2223	nitrite transmembrane transporter activity
H70737_RS26975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H70737_RS26995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H70737_RS27000	COG0210	DNA helicase
H70737_RS27005	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H70737_RS27015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H70737_RS27030	COG1091	dTDP-4-dehydrorhamnose reductase activity
H70737_RS27045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H70737_RS27055	COG0463	Glycosyl transferase, family 2
H70737_RS27080	COG0438	transferase activity, transferring glycosyl groups
H70737_RS27080	COG1216	Glycosyl transferase, family 2
H70737_RS27090	COG1134	teichoic acid transport
H70737_RS27105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H70737_RS27110	COG0826	peptidase U32
H70737_RS27120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H70737_RS27130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H70737_RS27135	COG0556	nucleotide-excision repair
H70737_RS27140	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H70737_RS27150	COG0509	glycine decarboxylation via glycine cleavage system
H70737_RS27155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H70737_RS27160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H70737_RS27165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H70737_RS27170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H70737_RS27175	COG0475	glutathione-regulated potassium exporter activity
H70737_RS27195	COG1131	(ABC) transporter
H70737_RS27205	COG2197	response regulator
H70737_RS27215	COG3409	Peptidoglycan-binding domain 1 protein
H70737_RS27215	COG0793	Belongs to the peptidase S41A family
H70737_RS27220	COG0739	heme binding
H70737_RS27225	COG2177	Part of the ABC transporter FtsEX involved in
H70737_RS27230	COG2884	Cell division ATP-binding protein ftsE
H70737_RS27235	COG2720	vancomycin resistance protein
H70737_RS27260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H70737_RS27270	COG1459	type II secretion system
H70737_RS27280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H70737_RS27310	COG5564	TIM-barrel signal transduction protein
H70737_RS27320	COG5564	TIM-barrel signal transduction protein
H70737_RS27325	COG0165	Argininosuccinate lyase
H70737_RS27330	COG0137	argininosuccinate synthase activity
H70737_RS27335	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H70737_RS27345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H70737_RS27350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H70737_RS27355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H70737_RS27360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS27365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H70737_RS27370	COG0653	protein targeting
H70737_RS27385	COG1278	Cold shock
H70737_RS27415	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H70737_RS27435	COG1216	Glycosyl transferase, family 2
H70737_RS27440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H70737_RS27450	COG0463	Glycosyl transferase, family 2
H70737_RS27450	COG0457	Tetratricopeptide repeat
H70737_RS27455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS27460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS27465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS27470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H70737_RS27475	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H70737_RS27485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H70737_RS27490	COG1256	bacterial-type flagellum assembly
H70737_RS27490	COG4786	Flagellar basal body rod
H70737_RS27515	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H70737_RS27545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H70737_RS27575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H70737_RS27595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H70737_RS27615	COG4786	Flagellar basal body rod
H70737_RS27625	COG1609	Transcriptional regulator
H70737_RS27630	COG0739	heme binding
H70737_RS27635	COG2385	sporulation resulting in formation of a cellular spore
H70737_RS27640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H70737_RS27645	COG4836	Membrane
H70737_RS27650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H70737_RS27655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H70737_RS27660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H70737_RS27665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H70737_RS27670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H70737_RS27675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H70737_RS27680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H70737_RS27685	COG0356	it plays a direct role in the translocation of protons across the membrane
H70737_RS27700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H70737_RS27710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H70737_RS27715	COG4475	Protein of unknown function (DUF436)
H70737_RS27725	COG1971	Probably functions as a manganese efflux pump
H70737_RS27730	COG0009	L-threonylcarbamoyladenylate synthase
H70737_RS27740	COG0772	Belongs to the SEDS family
H70737_RS27745	COG0772	Belongs to the SEDS family
H70737_RS27750	COG2890	protein-(glutamine-N5) methyltransferase activity
H70737_RS27755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H70737_RS27760	COG0012	GTP binding
H70737_RS27775	COG1304	FMN binding
H70737_RS27785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H70737_RS27790	COG1309	transcriptional regulator
H70737_RS27795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H70737_RS27800	COG3381	protein complex oligomerization
H70737_RS27810	COG2911	Protein conserved in bacteria
H70737_RS27810	COG1361	Conserved repeat domain
H70737_RS27810	COG3266	domain, Protein
H70737_RS27815	COG5002	protein histidine kinase activity
H70737_RS27825	COG1132	(ABC) transporter
H70737_RS27840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS27845	COG2258	MOSC domain
H70737_RS27855	COG2814	Major facilitator Superfamily
H70737_RS27860	COG2116	formate transmembrane transporter activity
H70737_RS27865	COG0446	pyridine nucleotide-disulphide oxidoreductase
H70737_RS27870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H70737_RS27875	COG0386	Belongs to the glutathione peroxidase family
H70737_RS27880	COG1876	peptidase activity
H70737_RS27890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H70737_RS27905	COG1587	Uroporphyrinogen-III synthase
H70737_RS27910	COG0840	transmembrane signaling receptor activity
H70737_RS27930	COG0697	spore germination
H70737_RS27935	COG0723	plastoquinol--plastocyanin reductase activity
H70737_RS27935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H70737_RS27940	COG0300	oxidoreductase activity
H70737_RS27980	COG0583	DNA-binding transcription factor activity
H70737_RS27985	COG1380	Effector of murein hydrolase LrgA
H70737_RS27990	COG1346	cytolysis
H70737_RS28005	COG1368	sulfuric ester hydrolase activity
H70737_RS28010	COG1846	Transcriptional regulator
H70737_RS28015	COG0840	transmembrane signaling receptor activity
H70737_RS28030	COG1131	(ABC) transporter
H70737_RS28035	COG1733	regulation of RNA biosynthetic process
H70737_RS28075	COG1575	Belongs to the MenA family. Type 1 subfamily
H70737_RS28090	COG2210	Belongs to the sulfur carrier protein TusA family
H70737_RS28110	COG1653	transport
H70737_RS28125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H70737_RS28130	COG0667	Aldo Keto reductase
H70737_RS28160	COG0493	'glutamate synthase
H70737_RS28170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H70737_RS28175	COG1012	belongs to the aldehyde dehydrogenase family
H70737_RS28180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H70737_RS28185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H70737_RS28210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H70737_RS28210	COG0392	lysyltransferase activity
H70737_RS28220	COG2814	Major facilitator Superfamily
H70737_RS28225	COG0400	carboxylic ester hydrolase activity
H70737_RS28230	COG0346	lactoylglutathione lyase activity
H70737_RS28235	COG2259	Doxx family
H70737_RS28240	COG1846	Transcriptional regulator
H70737_RS28245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H70737_RS28250	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H70737_RS28275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H70737_RS28280	COG1177	transmembrane transport
H70737_RS28285	COG1176	ABC-type spermidine putrescine transport system, permease component I
H70737_RS28290	COG3842	ATPase activity
H70737_RS28300	COG0697	spore germination
H70737_RS28305	COG0583	DNA-binding transcription factor activity
H70737_RS28310	COG0667	Aldo Keto reductase
H70737_RS28315	COG1012	belongs to the aldehyde dehydrogenase family
H70737_RS28325	COG0395	ABC-type sugar transport system, permease component
H70737_RS28330	COG1175	transmembrane transport
H70737_RS28335	COG1653	transport
H70737_RS28345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H70737_RS28355	COG3764	Sortase (surface protein transpeptidase)
H70737_RS28360	COG2195	Cleaves the N-terminal amino acid of tripeptides
H70737_RS28365	COG1733	regulation of RNA biosynthetic process
H70737_RS28370	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H70737_RS28375	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H70737_RS28380	COG0534	Mate efflux family protein
H70737_RS28385	COG2203	Gaf domain
H70737_RS28385	COG4585	Histidine kinase
H70737_RS28390	COG2197	response regulator
H70737_RS28395	COG0431	NADPH-dependent FMN reductase
H70737_RS28405	COG0346	lactoylglutathione lyase activity
H70737_RS28415	COG1278	Cold shock
H70737_RS28425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H70737_RS28445	COG0784	Response regulator, receiver
H70737_RS28445	COG5002	protein histidine kinase activity
H70737_RS28450	COG4912	Dna alkylation repair
H70737_RS28455	COG2199	diguanylate cyclase activity
H70737_RS28465	COG0254	rRNA binding
H70737_RS28480	COG1215	transferase activity, transferring glycosyl groups
H70737_RS28500	COG0753	catalase activity
H70737_RS28510	COG3766	membrane
H70737_RS28540	COG3835	regulator
H70737_RS28545	COG1929	Belongs to the glycerate kinase type-1 family
H70737_RS28550	COG2610	gluconate transmembrane transporter activity
H70737_RS28555	COG2233	PERMEase
H70737_RS28560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H70737_RS28570	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H70737_RS28580	COG2814	Major facilitator Superfamily
H70737_RS28585	COG0656	L-ascorbic acid biosynthetic process
H70737_RS28605	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H70737_RS28630	COG0322	excinuclease ABC activity
H70737_RS28645	COG3104	oligopeptide transport
H70737_RS28650	COG3069	C4-dicarboxylate transmembrane transporter activity
H70737_RS28660	COG1309	transcriptional regulator
H70737_RS28665	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H70737_RS28675	COG0840	transmembrane signaling receptor activity
H70737_RS28680	COG1408	metallophosphoesterase
H70737_RS28695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H70737_RS28735	COG5001	Diguanylate cyclase
H70737_RS28735	COG3300	MHYT domain
H70737_RS28745	COG2824	Alkylphosphonate utilization operon protein PhnA
H70737_RS28760	COG2197	response regulator
H70737_RS28775	COG2197	response regulator
H70737_RS28780	COG1704	LemA family
H70737_RS28800	COG2200	EAL domain
H70737_RS28820	COG0596	Alpha beta hydrolase
H70737_RS28825	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS28850	COG0745	RESPONSE REGULATOR receiver
H70737_RS28870	COG4589	Belongs to the CDS family
H70737_RS28885	COG0402	S-adenosylhomocysteine deaminase activity
H70737_RS28910	COG2197	response regulator
H70737_RS28925	COG1279	arginine transmembrane transporter activity
H70737_RS28935	COG1597	lipid kinase activity
H70737_RS28940	COG2814	Major facilitator Superfamily
H70737_RS28960	COG1115	amino acid carrier protein
H70737_RS28965	COG0753	catalase activity
H70737_RS28970	COG1086	Polysaccharide biosynthesis protein
H70737_RS28980	COG2318	DinB family
H70737_RS28985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H70737_RS29000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H70737_RS29020	COG1175	transmembrane transport
H70737_RS29025	COG0745	RESPONSE REGULATOR receiver
H70737_RS29030	COG5002	protein histidine kinase activity
H70737_RS29030	COG3850	Histidine kinase
H70737_RS29035	COG3665	Urea carboxylase-associated protein
H70737_RS29040	COG1280	lysine exporter protein (LysE YggA)
H70737_RS29045	COG3403	YqcI/YcgG family
H70737_RS29050	COG1113	amino acid transport
H70737_RS29055	COG5577	PFAM Coat F domain
H70737_RS29060	COG2271	Major facilitator Superfamily
H70737_RS29065	COG1309	transcriptional regulator
H70737_RS29075	COG4682	membrane
H70737_RS29085	COG2226	methyltransferase
H70737_RS29105	COG1653	transport
H70737_RS29110	COG0395	ABC-type sugar transport system, permease component
H70737_RS29115	COG4209	transmembrane transport
H70737_RS29125	COG2972	Histidine kinase
H70737_RS29130	COG1522	sequence-specific DNA binding
H70737_RS29140	COG3973	AAA domain
H70737_RS29145	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H70737_RS29150	COG1595	DNA-templated transcription, initiation
H70737_RS29165	COG0789	Transcriptional regulator
H70737_RS29175	COG1819	glycosyl
H70737_RS29180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H70737_RS29180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H70737_RS29180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H70737_RS29185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H70737_RS29185	COG3711	transcriptional antiterminator
H70737_RS29195	COG0534	Mate efflux family protein
H70737_RS29200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H70737_RS29225	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS29230	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS29235	COG2169	Transcriptional regulator
H70737_RS29240	COG1408	metallophosphoesterase
H70737_RS29250	COG2814	Major facilitator Superfamily
H70737_RS29255	COG3620	sequence-specific DNA binding
H70737_RS29260	COG1113	amino acid transport
H70737_RS29270	COG0477	Major facilitator Superfamily
H70737_RS29275	COG0667	Aldo Keto reductase
H70737_RS29300	COG0640	Transcriptional regulator
H70737_RS29310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H70737_RS29315	COG4988	ABC transporter
H70737_RS29320	COG1294	oxidase, subunit
H70737_RS29325	COG1271	oxidase subunit
H70737_RS29335	COG1278	Cold shock
H70737_RS29340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H70737_RS29350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H70737_RS29365	COG5002	protein histidine kinase activity
H70737_RS29370	COG0745	RESPONSE REGULATOR receiver
H70737_RS29375	COG0739	heme binding
H70737_RS29385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H70737_RS29390	COG0305	Participates in initiation and elongation during chromosome replication
H70737_RS29395	COG0359	binds to the 23S rRNA
H70737_RS29400	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H70737_RS29420	COG1316	TRANSCRIPTIONal
H70737_RS29435	COG1193	negative regulation of DNA recombination
H70737_RS29440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H70737_RS29445	COG0629	single-stranded DNA binding
H70737_RS29450	COG0360	Binds together with S18 to 16S ribosomal RNA
H70737_RS29465	COG4481	Protein conserved in bacteria
H70737_RS29470	COG0668	transmembrane transport
H70737_RS29490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H70737_RS29495	COG1475	DNA binding
H70737_RS29500	COG1192	Involved in chromosome partitioning
H70737_RS29505	COG1475	DNA binding
H70737_RS29510	COG0357	Ribosomal RNA small subunit methyltransferase G
H70737_RS29515	COG0445	tRNA wobble uridine modification
H70737_RS29520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H70737_RS29525	COG1847	R3H domain protein
H70737_RS29540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H70737_RS29570	COG1215	transferase activity, transferring glycosyl groups
H70737_RS29575	COG1442	glycosyl transferase family 8
H70737_RS29575	COG1216	Glycosyl transferase, family 2
H70737_RS29580	COG1649	PFAM Uncharacterised BCR, COG1649
H70737_RS29580	COG0726	polysaccharide deacetylase
H70737_RS29600	COG1309	transcriptional regulator
H70737_RS29615	COG0737	Belongs to the 5'-nucleotidase family
H70737_RS29635	COG2972	Histidine kinase
H70737_RS29680	COG1361	Conserved repeat domain
H70737_RS29700	COG1846	Transcriptional regulator
H70737_RS29705	COG3300	MHYT domain
H70737_RS29705	COG5001	Diguanylate cyclase
H70737_RS29735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H70737_RS29735	COG3291	Pkd domain containing protein
H70737_RS29770	COG0494	nUDIX hydrolase
H70737_RS29775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H70737_RS29810	COG0477	Major facilitator Superfamily
H70737_RS29820	COG5002	protein histidine kinase activity
H70737_RS29825	COG2376	Dihydroxyacetone kinase
H70737_RS29830	COG2972	Histidine kinase
H70737_RS29895	COG3279	Response regulator of the LytR AlgR family
H70737_RS29900	COG5002	protein histidine kinase activity
H70737_RS29905	COG1664	Polymer-forming cytoskeletal
H70737_RS29920	COG4585	Histidine kinase
H70737_RS29935	COG1361	Conserved repeat domain
H70737_RS29940	COG1404	Belongs to the peptidase S8 family
H70737_RS29945	COG1555	photosystem II stabilization
H70737_RS29950	COG1388	LysM domain
H70737_RS29960	COG2972	Histidine kinase
H70737_RS29985	COG1472	Belongs to the glycosyl hydrolase 3 family
H70737_RS29995	COG4470	Protein conserved in bacteria
H70737_RS30005	COG0463	Glycosyl transferase, family 2
H70737_RS30005	COG0457	Tetratricopeptide repeat
H70737_RS30025	COG3321	synthase
H70737_RS30025	COG1028	Short-chain dehydrogenase reductase Sdr
H70737_RS30025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H70737_RS30025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H70737_RS30025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H70737_RS30035	COG1682	transport, permease protein
H70737_RS30050	COG1361	Conserved repeat domain
H70737_RS30070	COG1752	Esterase of the alpha-beta hydrolase superfamily