locus-tag	class	description
E6C60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E6C60_RS00010	COG0592	DNA-directed DNA polymerase activity
E6C60_RS00015	COG2501	S4 domain
E6C60_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C60_RS00030	COG0187	DNA topoisomerase II activity
E6C60_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C60_RS00045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E6C60_RS00080	COG1982	Orn Lys Arg decarboxylase major
E6C60_RS00080	COG1982	Orn Lys Arg decarboxylase major
E6C60_RS00085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E6C60_RS00090	COG3870	Protein conserved in bacteria
E6C60_RS00095	COG1728	Protein conserved in bacteria
E6C60_RS00100	COG0470	DNA polymerase III
E6C60_RS00105	COG1774	PSP1 C-terminal conserved region
E6C60_RS00110	COG4467	Involved in initiation control of chromosome replication
E6C60_RS00115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E6C60_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E6C60_RS00125	COG2002	toxin-antitoxin pair type II binding
E6C60_RS00130	COG1078	dGTPase activity
E6C60_RS00135	COG0084	hydrolase, TatD family'
E6C60_RS00140	COG3583	domain protein
E6C60_RS00140	COG3584	3D domain protein
E6C60_RS00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E6C60_RS00160	COG4466	Protein conserved in bacteria
E6C60_RS00170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E6C60_RS00175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C60_RS00180	COG2088	sporulation resulting in formation of a cellular spore
E6C60_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E6C60_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C60_RS00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E6C60_RS00215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C60_RS00220	COG2002	toxin-antitoxin pair type II binding
E6C60_RS00225	COG2244	polysaccharide biosynthetic process
E6C60_RS00230	COG3956	TIGRFAM MazG family protein
E6C60_RS00240	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E6C60_RS00260	COG1098	S1 RNA binding domain
E6C60_RS00265	COG2208	phosphoserine phosphatase activity
E6C60_RS00270	COG2304	oxidoreductase activity
E6C60_RS00275	COG0515	serine threonine protein kinase
E6C60_RS00280	COG0037	tRNA processing
E6C60_RS00290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E6C60_RS00295	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E6C60_RS00300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E6C60_RS00315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E6C60_RS00320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C60_RS00325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C60_RS00330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E6C60_RS00335	COG0512	Glutamine amidotransferase of anthranilate synthase
E6C60_RS00340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E6C60_RS00345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E6C60_RS00355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E6C60_RS00360	COG1396	sequence-specific DNA binding
E6C60_RS00365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C60_RS00370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C60_RS00380	COG3226	Transcriptional regulator
E6C60_RS00405	COG0517	IMP dehydrogenase activity
E6C60_RS00405	COG0516	GMP reductase activity
E6C60_RS00425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C60_RS00455	COG0590	tRNA wobble adenosine to inosine editing
E6C60_RS00460	COG5002	protein histidine kinase activity
E6C60_RS00465	COG1187	pseudouridine synthase activity
E6C60_RS00470	COG1360	Flagellar Motor Protein
E6C60_RS00475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C60_RS00485	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C60_RS00500	COG0791	NLP P60 protein
E6C60_RS00500	COG1388	LysM domain
E6C60_RS00525	COG1970	mechanosensitive ion channel activity
E6C60_RS00530	COG2094	Belongs to the DNA glycosylase MPG family
E6C60_RS00535	COG3064	Membrane
E6C60_RS00540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E6C60_RS00545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E6C60_RS00550	COG0010	Belongs to the arginase family
E6C60_RS00555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C60_RS00555	COG3153	acetyltransferase
E6C60_RS00560	COG0456	acetyltransferase
E6C60_RS00575	COG0018	arginyl-trna synthetase
E6C60_RS00580	COG1404	Belongs to the peptidase S8 family
E6C60_RS00585	COG3343	RNA polymerase activity
E6C60_RS00590	COG0504	CTP synthase activity
E6C60_RS00605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C60_RS00610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E6C60_RS00620	COG0254	rRNA binding
E6C60_RS00630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E6C60_RS00635	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E6C60_RS00640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E6C60_RS00720	COG2508	Transcriptional regulator
E6C60_RS00725	COG3842	ATPase activity
E6C60_RS00730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E6C60_RS00735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E6C60_RS00740	COG0546	phosphoglycolate phosphatase activity
E6C60_RS00745	COG0110	maltose O-acetyltransferase activity
E6C60_RS00760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E6C60_RS00765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E6C60_RS00770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E6C60_RS00775	COG0131	Imidazoleglycerol-phosphate dehydratase
E6C60_RS00780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C60_RS00785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E6C60_RS00790	COG0107	imidazoleglycerol-phosphate synthase activity
E6C60_RS00795	COG0140	phosphoribosyl-ATP diphosphatase activity
E6C60_RS00795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E6C60_RS00800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E6C60_RS00830	COG5337	Spore coat protein CotH
E6C60_RS00835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C60_RS00840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS00845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS00860	COG2197	response regulator
E6C60_RS00865	COG4585	Histidine kinase
E6C60_RS00870	COG0842	Transport permease protein
E6C60_RS00875	COG1131	(ABC) transporter
E6C60_RS00885	COG1940	carbohydrate kinase activity
E6C60_RS00890	COG1660	Displays ATPase and GTPase activities
E6C60_RS00895	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E6C60_RS00900	COG1481	regulation of sporulation
E6C60_RS00905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C60_RS00910	COG2207	Transcriptional regulator
E6C60_RS00915	COG4209	transmembrane transport
E6C60_RS00920	COG0395	ABC-type sugar transport system, permease component
E6C60_RS00925	COG1653	transport
E6C60_RS00945	COG3119	arylsulfatase activity
E6C60_RS00960	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C60_RS00965	COG1177	transmembrane transport
E6C60_RS00970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E6C60_RS00980	COG0740	serine-type endopeptidase activity
E6C60_RS00995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E6C60_RS01005	COG0149	triose-phosphate isomerase activity
E6C60_RS01010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E6C60_RS01015	COG0148	phosphopyruvate hydratase activity
E6C60_RS01040	COG4948	Mandelate Racemase Muconate Lactonizing
E6C60_RS01060	COG0800	Aldolase
E6C60_RS01070	COG3119	arylsulfatase activity
E6C60_RS01075	COG3119	arylsulfatase activity
E6C60_RS01085	COG3119	arylsulfatase activity
E6C60_RS01090	COG3250	beta-galactosidase activity
E6C60_RS01100	COG2186	Transcriptional regulator
E6C60_RS01105	COG0277	FAD linked oxidase domain protein
E6C60_RS01110	COG0247	lactate metabolic process
E6C60_RS01115	COG1737	Transcriptional regulator
E6C60_RS01120	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E6C60_RS01130	COG1175	transmembrane transport
E6C60_RS01135	COG0395	ABC-type sugar transport system, permease component
E6C60_RS01140	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E6C60_RS01145	COG3876	Protein conserved in bacteria
E6C60_RS01150	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C60_RS01155	COG2971	BadF BadG BcrA BcrD
E6C60_RS01165	COG1175	transmembrane transport
E6C60_RS01170	COG0395	ABC-type sugar transport system, permease component
E6C60_RS01175	COG1653	transport
E6C60_RS01185	COG4209	transmembrane transport
E6C60_RS01190	COG0395	ABC-type sugar transport system, permease component
E6C60_RS01195	COG1653	transport
E6C60_RS01205	COG1653	transport
E6C60_RS01210	COG1653	transport
E6C60_RS01245	COG2207	Transcriptional regulator
E6C60_RS01245	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS01255	COG3119	arylsulfatase activity
E6C60_RS01265	COG3344	reverse transcriptase
E6C60_RS01280	COG1132	(ABC) transporter
E6C60_RS01285	COG1132	(ABC) transporter
E6C60_RS01320	COG1199	ATP-dependent helicase activity
E6C60_RS01360	COG1960	acyl-CoA dehydrogenase activity
E6C60_RS01365	COG2814	Major facilitator Superfamily
E6C60_RS01370	COG1733	regulation of RNA biosynthetic process
E6C60_RS01375	COG2072	flavoprotein involved in K transport
E6C60_RS01385	COG0640	Transcriptional regulator
E6C60_RS01400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E6C60_RS01405	COG0557	exoribonuclease II activity
E6C60_RS01410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E6C60_RS01455	COG3328	transposase activity
E6C60_RS01550	COG0154	amidase activity
E6C60_RS01570	COG2962	Rard protein
E6C60_RS01590	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E6C60_RS01600	COG3279	Response regulator of the LytR AlgR family
E6C60_RS01615	COG4209	transmembrane transport
E6C60_RS01620	COG0395	ABC-type sugar transport system, permease component
E6C60_RS01625	COG1653	transport
E6C60_RS01635	COG4753	response regulator
E6C60_RS01635	COG2207	Transcriptional regulator
E6C60_RS01675	COG2273	Hydrolase Family 16
E6C60_RS01685	COG2323	membrane
E6C60_RS01700	COG1842	Phage shock protein A
E6C60_RS01705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E6C60_RS01715	COG4260	virion core protein, lumpy skin disease virus
E6C60_RS01760	COG1131	(ABC) transporter
E6C60_RS01775	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C60_RS01780	COG3845	ABC transporter
E6C60_RS01785	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS01790	COG1079	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS01795	COG1595	DNA-templated transcription, initiation
E6C60_RS01810	COG2207	Transcriptional regulator
E6C60_RS01825	COG0534	Mate efflux family protein
E6C60_RS01835	COG0395	ABC-type sugar transport system, permease component
E6C60_RS01840	COG1175	transmembrane transport
E6C60_RS01855	COG3275	phosphorelay sensor kinase activity
E6C60_RS01860	COG2207	Transcriptional regulator
E6C60_RS01860	COG4753	response regulator
E6C60_RS01865	COG1653	transport
E6C60_RS01870	COG0366	Alpha amylase catalytic
E6C60_RS01870	COG1874	Beta-galactosidase
E6C60_RS01875	COG0572	uridine kinase
E6C60_RS01885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C60_RS01890	COG4715	Zinc finger, swim domain protein
E6C60_RS01900	COG3622	Belongs to the hyi family
E6C60_RS01930	COG1482	cell wall glycoprotein biosynthetic process
E6C60_RS01935	COG4977	sequence-specific DNA binding
E6C60_RS01935	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS01945	COG1027	Aspartate ammonia-lyase
E6C60_RS01960	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E6C60_RS01965	COG0640	Transcriptional regulator
E6C60_RS01990	COG0436	Aminotransferase
E6C60_RS01995	COG0028	Belongs to the TPP enzyme family
E6C60_RS02000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C60_RS02005	COG1132	(ABC) transporter
E6C60_RS02010	COG1132	(ABC) transporter
E6C60_RS02025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C60_RS02040	COG2207	Transcriptional regulator
E6C60_RS02075	COG1760	l-serine dehydratase
E6C60_RS02080	COG1760	l-serine dehydratase
E6C60_RS02095	COG4209	transmembrane transport
E6C60_RS02100	COG0395	ABC-type sugar transport system, permease component
E6C60_RS02105	COG2207	Transcriptional regulator
E6C60_RS02115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C60_RS02120	COG1984	allophanate hydrolase subunit 2
E6C60_RS02125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E6C60_RS02135	COG1595	DNA-templated transcription, initiation
E6C60_RS02155	COG1278	Cold shock
E6C60_RS02165	COG2116	formate transmembrane transporter activity
E6C60_RS02170	COG0778	Nitroreductase
E6C60_RS02185	COG0656	L-ascorbic acid biosynthetic process
E6C60_RS02190	COG2814	Major facilitator Superfamily
E6C60_RS02195	COG0210	DNA helicase
E6C60_RS02200	COG4989	oxidoreductase activity
E6C60_RS02215	COG3437	response regulator, receiver
E6C60_RS02225	COG2608	mercury ion transmembrane transporter activity
E6C60_RS02235	COG0708	Exodeoxyribonuclease III
E6C60_RS02240	COG0084	hydrolase, TatD family'
E6C60_RS02245	COG1116	anion transmembrane transporter activity
E6C60_RS02250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C60_RS02260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C60_RS02265	COG0346	lactoylglutathione lyase activity
E6C60_RS02270	COG3871	stress protein (general stress protein 26)
E6C60_RS02275	COG5001	Diguanylate cyclase
E6C60_RS02285	COG1554	hydrolase, family 65, central catalytic
E6C60_RS02290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C60_RS02295	COG1609	Transcriptional regulator
E6C60_RS02305	COG0745	RESPONSE REGULATOR receiver
E6C60_RS02310	COG2205	protein histidine kinase activity
E6C60_RS02345	COG2972	Histidine kinase
E6C60_RS02345	COG0745	RESPONSE REGULATOR receiver
E6C60_RS02355	COG0840	transmembrane signaling receptor activity
E6C60_RS02355	COG5278	phosphoserine phosphatase activity
E6C60_RS02360	COG5001	Diguanylate cyclase
E6C60_RS02360	COG3300	MHYT domain
E6C60_RS02365	COG1937	Protein conserved in bacteria
E6C60_RS02370	COG0425	Belongs to the sulfur carrier protein TusA family
E6C60_RS02375	COG2210	Belongs to the sulfur carrier protein TusA family
E6C60_RS02380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E6C60_RS02380	COG0425	Belongs to the sulfur carrier protein TusA family
E6C60_RS02385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C60_RS02385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E6C60_RS02390	COG2130	NADP-dependent
E6C60_RS02395	COG3706	GGDEF domain
E6C60_RS02400	COG4846	Membrane protein involved in cytochrome C biogenesis
E6C60_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C60_RS02415	COG1595	DNA-templated transcription, initiation
E6C60_RS02435	COG2706	6-phosphogluconolactonase activity
E6C60_RS02445	COG2910	NAD(P)H-binding
E6C60_RS02450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C60_RS02450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E6C60_RS02460	COG0431	NADPH-dependent FMN reductase
E6C60_RS02480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E6C60_RS02485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E6C60_RS02490	COG0011	TIGRFAM Protein of
E6C60_RS02500	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS02535	COG2770	Histidine kinase
E6C60_RS02535	COG3437	response regulator, receiver
E6C60_RS02540	COG0805	protein transport
E6C60_RS02560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C60_RS02590	COG2205	protein histidine kinase activity
E6C60_RS02590	COG3437	response regulator, receiver
E6C60_RS02590	COG3850	Histidine kinase
E6C60_RS02590	COG4999	Histidine kinase
E6C60_RS02605	COG0251	oxidation-reduction process
E6C60_RS02615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C60_RS02625	COG1876	peptidase activity
E6C60_RS02650	COG1408	metallophosphoesterase
E6C60_RS02680	COG0024	Methionine aminopeptidase
E6C60_RS02685	COG2010	Cytochrome c
E6C60_RS02685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C60_RS02700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E6C60_RS02705	COG3336	cytochrome c oxidase
E6C60_RS02725	COG1122	ATPase activity
E6C60_RS02730	COG4152	abc transporter atp-binding protein
E6C60_RS02735	COG1668	transmembrane transport
E6C60_RS02750	COG0693	protein deglycase activity
E6C60_RS02785	COG1136	(ABC) transporter
E6C60_RS02800	COG0492	ferredoxin-NADP+ reductase activity
E6C60_RS02805	COG3069	C4-dicarboxylate transmembrane transporter activity
E6C60_RS02870	COG0463	Glycosyl transferase, family 2
E6C60_RS02870	COG0457	Tetratricopeptide repeat
E6C60_RS02885	COG0662	Cupin 2, conserved barrel domain protein
E6C60_RS02885	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E6C60_RS02890	COG0457	Tetratricopeptide repeat
E6C60_RS02890	COG0463	Glycosyl transferase, family 2
E6C60_RS02925	COG0109	protoheme IX farnesyltransferase activity
E6C60_RS02930	COG1609	Transcriptional regulator
E6C60_RS02935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C60_RS02940	COG1869	D-ribose catabolic process
E6C60_RS02945	COG1129	ABC transporter
E6C60_RS02950	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS02955	COG1879	ABC-type sugar transport system periplasmic component
E6C60_RS02965	COG0673	inositol 2-dehydrogenase activity
E6C60_RS02975	COG0673	inositol 2-dehydrogenase activity
E6C60_RS02985	COG0789	Transcriptional regulator
E6C60_RS03005	COG1968	undecaprenyl-diphosphatase activity
E6C60_RS03010	COG0586	Pfam SNARE associated Golgi protein
E6C60_RS03015	COG1902	pentaerythritol trinitrate reductase activity
E6C60_RS03020	COG2205	protein histidine kinase activity
E6C60_RS03025	COG0745	RESPONSE REGULATOR receiver
E6C60_RS03035	COG3883	PFAM NLP P60 protein
E6C60_RS03035	COG0791	NLP P60 protein
E6C60_RS03040	COG4895	conserved protein (DUF2196)
E6C60_RS03050	COG1956	GAF domain-containing protein
E6C60_RS03060	COG1073	alpha beta
E6C60_RS03075	COG1122	ATPase activity
E6C60_RS03085	COG3344	reverse transcriptase
E6C60_RS03090	COG1131	(ABC) transporter
E6C60_RS03100	COG2081	HI0933 family
E6C60_RS03110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E6C60_RS03115	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C60_RS03125	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E6C60_RS03130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E6C60_RS03135	COG0456	acetyltransferase
E6C60_RS03145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E6C60_RS03150	COG3763	UPF0154 protein
E6C60_RS03155	COG0302	gtp cyclohydrolase
E6C60_RS03160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E6C60_RS03170	COG1414	Transcriptional regulator
E6C60_RS03175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E6C60_RS03185	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C60_RS03195	COG4294	response to UV
E6C60_RS03200	COG0483	inositol monophosphate 1-phosphatase activity
E6C60_RS03225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E6C60_RS03240	COG1252	NADH dehydrogenase
E6C60_RS03245	COG0714	Associated with various cellular activities
E6C60_RS03255	COG1305	Transglutaminase-like
E6C60_RS03260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E6C60_RS03260	COG0519	Catalyzes the synthesis of GMP from XMP
E6C60_RS03265	COG4974	Belongs to the 'phage' integrase family
E6C60_RS03365	COG0732	type I restriction modification DNA specificity domain
E6C60_RS03370	COG0732	type I restriction modification DNA specificity domain
E6C60_RS03390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C60_RS03400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C60_RS03405	COG0107	imidazoleglycerol-phosphate synthase activity
E6C60_RS03440	COG2252	PERMEase
E6C60_RS03460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C60_RS03475	COG0395	ABC-type sugar transport system, permease component
E6C60_RS03480	COG2972	Histidine kinase
E6C60_RS03485	COG1653	transport
E6C60_RS03490	COG4753	response regulator
E6C60_RS03490	COG2207	Transcriptional regulator
E6C60_RS03495	COG2261	transglycosylase associated protein
E6C60_RS03500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C60_RS03510	COG0737	Belongs to the 5'-nucleotidase family
E6C60_RS03515	COG0673	inositol 2-dehydrogenase activity
E6C60_RS03520	COG3326	Membrane
E6C60_RS03525	COG0589	response to stress
E6C60_RS03530	COG3344	reverse transcriptase
E6C60_RS03535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E6C60_RS03540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E6C60_RS03545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E6C60_RS03555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C60_RS03560	COG0047	phosphoribosylformylglycinamidine synthase activity
E6C60_RS03565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C60_RS03570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E6C60_RS03575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E6C60_RS03580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E6C60_RS03590	COG0151	Belongs to the GarS family
E6C60_RS03595	COG2182	Extracellular solute-binding protein
E6C60_RS03600	COG1175	transmembrane transport
E6C60_RS03605	COG3833	ABC-type maltose transport systems, permease component
E6C60_RS03610	COG0840	transmembrane signaling receptor activity
E6C60_RS03625	COG0346	lactoylglutathione lyase activity
E6C60_RS03630	COG0400	carboxylic ester hydrolase activity
E6C60_RS03640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C60_RS03660	COG1470	cell adhesion involved in biofilm formation
E6C60_RS03665	COG1392	Phosphate transport regulator
E6C60_RS03670	COG0306	phosphate transporter
E6C60_RS03675	COG0598	Magnesium transport protein CorA
E6C60_RS03690	COG4496	protein, YerC YecD
E6C60_RS03700	COG1597	lipid kinase activity
E6C60_RS03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E6C60_RS03725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C60_RS03730	COG0210	DNA helicase
E6C60_RS03780	COG4209	transmembrane transport
E6C60_RS03785	COG0395	ABC-type sugar transport system, permease component
E6C60_RS03790	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C60_RS03795	COG3250	beta-galactosidase activity
E6C60_RS03820	COG1653	transport
E6C60_RS03825	COG3119	arylsulfatase activity
E6C60_RS03830	COG2207	Transcriptional regulator
E6C60_RS03835	COG1653	transport
E6C60_RS03840	COG4209	transmembrane transport
E6C60_RS03845	COG0395	ABC-type sugar transport system, permease component
E6C60_RS03860	COG3119	arylsulfatase activity
E6C60_RS03865	COG3250	beta-galactosidase activity
E6C60_RS03870	COG3119	arylsulfatase activity
E6C60_RS03870	COG3408	Glycogen debranching enzyme
E6C60_RS03880	COG2207	Transcriptional regulator
E6C60_RS03880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C60_RS03885	COG3250	beta-galactosidase activity
E6C60_RS03890	COG3119	arylsulfatase activity
E6C60_RS03895	COG3119	arylsulfatase activity
E6C60_RS03900	COG2207	Transcriptional regulator
E6C60_RS03905	COG4209	transmembrane transport
E6C60_RS03910	COG0395	ABC-type sugar transport system, permease component
E6C60_RS03915	COG1653	transport
E6C60_RS03930	COG2972	Histidine kinase
E6C60_RS03935	COG4753	response regulator
E6C60_RS03935	COG2207	Transcriptional regulator
E6C60_RS03940	COG1653	transport
E6C60_RS03945	COG1175	transmembrane transport
E6C60_RS03950	COG0395	ABC-type sugar transport system, permease component
E6C60_RS03970	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS03970	COG4977	sequence-specific DNA binding
E6C60_RS03980	COG3693	PFAM glycoside hydrolase, family 10
E6C60_RS03990	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
E6C60_RS03995	COG2942	2-epimerase
E6C60_RS04015	COG4977	sequence-specific DNA binding
E6C60_RS04015	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS04025	COG1486	melibiose metabolic process
E6C60_RS04030	COG3119	arylsulfatase activity
E6C60_RS04035	COG3119	arylsulfatase activity
E6C60_RS04040	COG4753	response regulator
E6C60_RS04040	COG2207	Transcriptional regulator
E6C60_RS04045	COG3275	phosphorelay sensor kinase activity
E6C60_RS04050	COG4209	transmembrane transport
E6C60_RS04055	COG0395	ABC-type sugar transport system, permease component
E6C60_RS04060	COG1653	transport
E6C60_RS04065	COG1653	transport
E6C60_RS04070	COG3328	transposase activity
E6C60_RS04075	COG3119	arylsulfatase activity
E6C60_RS04080	COG3507	Belongs to the glycosyl hydrolase 43 family
E6C60_RS04085	COG1653	transport
E6C60_RS04105	COG5002	protein histidine kinase activity
E6C60_RS04110	COG0745	RESPONSE REGULATOR receiver
E6C60_RS04120	COG1132	(ABC) transporter
E6C60_RS04125	COG1132	(ABC) transporter
E6C60_RS04130	COG2207	Transcriptional regulator
E6C60_RS04130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C60_RS04140	COG0398	Pfam SNARE associated Golgi protein
E6C60_RS04145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C60_RS04160	COG4753	response regulator
E6C60_RS04160	COG4753	response regulator
E6C60_RS04160	COG2207	Transcriptional regulator
E6C60_RS04160	COG2207	Transcriptional regulator
E6C60_RS04165	COG2972	Histidine kinase
E6C60_RS04170	COG4209	transmembrane transport
E6C60_RS04175	COG0395	ABC-type sugar transport system, permease component
E6C60_RS04180	COG1653	transport
E6C60_RS04200	COG3481	metal-dependent phosphohydrolase, HD sub domain
E6C60_RS04205	COG0398	Pfam SNARE associated Golgi protein
E6C60_RS04225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C60_RS04350	COG0673	inositol 2-dehydrogenase activity
E6C60_RS04355	COG3119	arylsulfatase activity
E6C60_RS04365	COG0613	PHP domain protein
E6C60_RS04375	COG1175	transmembrane transport
E6C60_RS04380	COG0395	ABC-type sugar transport system, permease component
E6C60_RS04390	COG0823	Involved in the tonB-independent uptake of proteins
E6C60_RS04395	COG2186	Transcriptional regulator
E6C60_RS04415	COG4085	toxin activity
E6C60_RS04415	COG0737	Belongs to the 5'-nucleotidase family
E6C60_RS04415	COG0737	Belongs to the 5'-nucleotidase family
E6C60_RS04415	COG1525	nuclease
E6C60_RS04415	COG4085	toxin activity
E6C60_RS04415	COG1525	nuclease
E6C60_RS04435	COG2200	EAL domain
E6C60_RS04435	COG2199	diguanylate cyclase activity
E6C60_RS04445	COG0531	amino acid
E6C60_RS04455	COG3665	Urea carboxylase-associated protein
E6C60_RS04460	COG0439	Biotin carboxylase
E6C60_RS04470	COG0840	transmembrane signaling receptor activity
E6C60_RS04625	COG3328	transposase activity
E6C60_RS04675	COG5444	nuclease activity
E6C60_RS04700	COG1316	TRANSCRIPTIONal
E6C60_RS04765	COG0494	nUDIX hydrolase
E6C60_RS04780	COG1061	Type III restriction enzyme res subunit
E6C60_RS04865	COG0778	Nitroreductase
E6C60_RS04880	COG0840	transmembrane signaling receptor activity
E6C60_RS04895	COG0737	Belongs to the 5'-nucleotidase family
E6C60_RS04915	COG3639	organic phosphonate transmembrane transporter activity
E6C60_RS04920	COG2084	Dehydrogenase
E6C60_RS04930	COG3119	arylsulfatase activity
E6C60_RS04935	COG1309	transcriptional regulator
E6C60_RS04945	COG0667	Aldo Keto reductase
E6C60_RS04950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E6C60_RS04955	COG0351	phosphomethylpyrimidine kinase
E6C60_RS04990	COG0415	Belongs to the DNA photolyase family
E6C60_RS04995	COG2378	regulation of single-species biofilm formation
E6C60_RS05015	COG1653	transport
E6C60_RS05020	COG4209	transmembrane transport
E6C60_RS05025	COG0395	ABC-type sugar transport system, permease component
E6C60_RS05035	COG0473	3-isopropylmalate dehydrogenase activity
E6C60_RS05070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E6C60_RS05090	COG0523	cobalamin synthesis protein
E6C60_RS05100	COG0673	inositol 2-dehydrogenase activity
E6C60_RS05110	COG1090	epimerase
E6C60_RS05115	COG1388	LysM domain
E6C60_RS05115	COG0791	NLP P60 protein
E6C60_RS05120	COG2207	Transcriptional regulator
E6C60_RS05130	COG1744	ABC transporter substrate-binding protein PnrA-like
E6C60_RS05135	COG3845	ABC transporter
E6C60_RS05140	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS05145	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS05150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C60_RS05190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C60_RS05195	COG0601	transmembrane transport
E6C60_RS05225	COG1129	ABC transporter
E6C60_RS05230	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS05235	COG0824	Thioesterase
E6C60_RS05240	COG0673	inositol 2-dehydrogenase activity
E6C60_RS05245	COG3239	Fatty acid desaturase
E6C60_RS05250	COG4585	Histidine kinase
E6C60_RS05255	COG2197	response regulator
E6C60_RS05260	COG2059	Chromate
E6C60_RS05265	COG2059	Chromate
E6C60_RS05270	COG3428	Bacterial PH domain
E6C60_RS05280	COG1090	epimerase
E6C60_RS05295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E6C60_RS05320	COG0494	nUDIX hydrolase
E6C60_RS05325	COG0456	acetyltransferase
E6C60_RS05325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E6C60_RS05355	COG3266	domain, Protein
E6C60_RS05355	COG2911	Protein conserved in bacteria
E6C60_RS05355	COG1361	Conserved repeat domain
E6C60_RS05360	COG2226	methyltransferase
E6C60_RS05375	COG0395	ABC-type sugar transport system, permease component
E6C60_RS05380	COG3119	arylsulfatase activity
E6C60_RS05390	COG3459	Glycosyltransferase 36 associated
E6C60_RS05395	COG1609	Transcriptional regulator
E6C60_RS05400	COG0643	Histidine kinase
E6C60_RS05400	COG2198	Histidine kinase
E6C60_RS05405	COG0835	chemotaxis
E6C60_RS05410	COG0840	transmembrane signaling receptor activity
E6C60_RS05420	COG2201	protein-glutamate methylesterase activity
E6C60_RS05445	COG0668	transmembrane transport
E6C60_RS05460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E6C60_RS05465	COG0583	DNA-binding transcription factor activity
E6C60_RS05485	COG3118	belongs to the thioredoxin family
E6C60_RS05495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS05505	COG3706	GGDEF domain
E6C60_RS05515	COG1132	(ABC) transporter
E6C60_RS05520	COG1132	(ABC) transporter
E6C60_RS05525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS05540	COG1215	transferase activity, transferring glycosyl groups
E6C60_RS05545	COG1215	transferase activity, transferring glycosyl groups
E6C60_RS05555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C60_RS05565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C60_RS05570	COG2011	ABC-type metal ion transport system permease component
E6C60_RS05590	COG1595	DNA-templated transcription, initiation
E6C60_RS05600	COG3458	cephalosporin-C deacetylase activity
E6C60_RS05615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C60_RS05625	COG1335	isochorismatase
E6C60_RS05635	COG4474	Belongs to the UPF0398 family
E6C60_RS05650	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E6C60_RS05655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C60_RS05660	COG1309	transcriptional regulator
E6C60_RS05670	COG1876	peptidase activity
E6C60_RS05680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E6C60_RS05690	COG0300	oxidoreductase activity
E6C60_RS05695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E6C60_RS05710	COG1794	racemase activity, acting on amino acids and derivatives
E6C60_RS05715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C60_RS05720	COG2205	protein histidine kinase activity
E6C60_RS05725	COG2205	protein histidine kinase activity
E6C60_RS05750	COG0783	Belongs to the Dps family
E6C60_RS05755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E6C60_RS05765	COG0720	synthase
E6C60_RS05770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E6C60_RS05800	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS05815	COG0463	Glycosyl transferase, family 2
E6C60_RS05820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E6C60_RS05850	COG4641	Protein conserved in bacteria
E6C60_RS05855	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS05865	COG1086	Polysaccharide biosynthesis protein
E6C60_RS05890	COG0363	glucosamine-6-phosphate deaminase activity
E6C60_RS05895	COG1737	Transcriptional regulator
E6C60_RS05900	COG2197	response regulator
E6C60_RS05915	COG2207	Transcriptional regulator
E6C60_RS05915	COG4753	response regulator
E6C60_RS05920	COG2972	Histidine kinase
E6C60_RS05925	COG4209	transmembrane transport
E6C60_RS05930	COG0395	ABC-type sugar transport system, permease component
E6C60_RS05935	COG1653	transport
E6C60_RS05975	COG0442	prolyl-tRNA aminoacylation
E6C60_RS05985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C60_RS05990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C60_RS05995	COG0058	SHG alpha-glucan phosphorylase activity
E6C60_RS06005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E6C60_RS06010	COG5401	PFAM Sporulation and spore germination
E6C60_RS06015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E6C60_RS06020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E6C60_RS06025	COG0367	asparagine synthase
E6C60_RS06055	COG0018	arginyl-trna synthetase
E6C60_RS06060	COG2226	methyltransferase
E6C60_RS06075	COG0544	peptidyl-prolyl cis-trans isomerase activity
E6C60_RS06080	COG0740	serine-type endopeptidase activity
E6C60_RS06085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E6C60_RS06095	COG0470	DNA polymerase III
E6C60_RS06095	COG1067	ATP-dependent peptidase activity
E6C60_RS06105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E6C60_RS06115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E6C60_RS06125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C60_RS06130	COG1648	precorrin-2 dehydrogenase activity
E6C60_RS06130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C60_RS06145	COG0113	porphobilinogen synthase activity
E6C60_RS06150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E6C60_RS06155	COG0564	pseudouridine synthase activity
E6C60_RS06160	COG1388	LysM domain
E6C60_RS06160	COG1388	LysM domain
E6C60_RS06165	COG0525	valine-tRNA ligase activity
E6C60_RS06170	COG0285	dihydrofolate synthase activity
E6C60_RS06175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E6C60_RS06190	COG0424	maF-like protein
E6C60_RS06195	COG2003	Belongs to the UPF0758 family
E6C60_RS06200	COG1077	Cell shape determining protein MreB Mrl
E6C60_RS06220	COG2894	cell division
E6C60_RS06230	COG1994	Peptidase M50
E6C60_RS06235	COG1530	ribonuclease E activity
E6C60_RS06240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E6C60_RS06245	COG2868	ribosomal protein
E6C60_RS06250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E6C60_RS06260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E6C60_RS06265	COG4492	Belongs to the UPF0735 family
E6C60_RS06275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E6C60_RS06280	COG0083	homoserine kinase activity
E6C60_RS06285	COG0077	Prephenate dehydratase
E6C60_RS06290	COG1388	LysM domain
E6C60_RS06290	COG0791	NLP P60 protein
E6C60_RS06365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E6C60_RS06370	COG0632	four-way junction helicase activity
E6C60_RS06375	COG2255	four-way junction helicase activity
E6C60_RS06380	COG2385	sporulation resulting in formation of a cellular spore
E6C60_RS06380	COG2247	cell wall binding repeat
E6C60_RS06385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E6C60_RS06395	COG1862	Preprotein translocase
E6C60_RS06410	COG2323	membrane
E6C60_RS06415	COG2244	polysaccharide biosynthetic process
E6C60_RS06425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C60_RS06425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C60_RS06430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C60_RS06430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C60_RS06440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E6C60_RS06440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E6C60_RS06445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C60_RS06455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E6C60_RS06460	COG1490	D-aminoacyl-tRNA deacylase activity
E6C60_RS06475	COG0124	histidyl-tRNA synthetase
E6C60_RS06480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E6C60_RS06485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E6C60_RS06490	COG3973	AAA domain
E6C60_RS06495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E6C60_RS06500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E6C60_RS06505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E6C60_RS06530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C60_RS06540	COG4209	transmembrane transport
E6C60_RS06545	COG0395	ABC-type sugar transport system, permease component
E6C60_RS06550	COG1653	transport
E6C60_RS06560	COG4209	transmembrane transport
E6C60_RS06565	COG0395	ABC-type sugar transport system, permease component
E6C60_RS06585	COG2207	Transcriptional regulator
E6C60_RS06585	COG4753	response regulator
E6C60_RS06590	COG2972	Histidine kinase
E6C60_RS06600	COG0482	sulfurtransferase activity
E6C60_RS06605	COG1959	2 iron, 2 sulfur cluster binding
E6C60_RS06610	COG1104	cysteine desulfurase activity
E6C60_RS06625	COG0628	permease
E6C60_RS06630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E6C60_RS06655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E6C60_RS06660	COG0826	peptidase U32
E6C60_RS06665	COG0826	peptidase U32
E6C60_RS06670	COG0840	transmembrane signaling receptor activity
E6C60_RS06675	COG0768	penicillin binding
E6C60_RS06680	COG0546	phosphoglycolate phosphatase activity
E6C60_RS06685	COG0628	permease
E6C60_RS06695	COG0129	dihydroxy-acid dehydratase activity
E6C60_RS06705	COG0546	phosphoglycolate phosphatase activity
E6C60_RS06710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E6C60_RS06715	COG0667	Aldo Keto reductase
E6C60_RS06725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E6C60_RS06730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E6C60_RS06735	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E6C60_RS06740	COG1979	alcohol dehydrogenase
E6C60_RS06750	COG2268	Band 7 protein
E6C60_RS06755	COG0436	Aminotransferase
E6C60_RS06760	COG3711	transcriptional antiterminator
E6C60_RS06765	COG2190	(PTS) system
E6C60_RS06765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C60_RS06765	COG1263	PTS System
E6C60_RS06770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C60_RS06780	COG1523	belongs to the glycosyl hydrolase 13 family
E6C60_RS06785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E6C60_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS06795	COG1349	DNA-binding transcription factor activity
E6C60_RS06800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E6C60_RS06805	COG2160	L-arabinose isomerase activity
E6C60_RS06820	COG1069	ribulokinase activity
E6C60_RS06825	COG0366	Alpha amylase catalytic
E6C60_RS06835	COG0657	acetylesterase activity
E6C60_RS06835	COG2755	lipolytic protein G-D-S-L family
E6C60_RS06840	COG0693	protein deglycase activity
E6C60_RS06885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C60_RS06890	COG1388	LysM domain
E6C60_RS06905	COG0395	ABC-type sugar transport system, permease component
E6C60_RS06910	COG1175	transmembrane transport
E6C60_RS06925	COG2972	Histidine kinase
E6C60_RS06940	COG5285	phytanoyl-CoA dioxygenase
E6C60_RS06945	COG1363	Peptidase, m42
E6C60_RS06955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C60_RS06965	COG0714	Associated with various cellular activities
E6C60_RS06975	COG1305	Transglutaminase-like
E6C60_RS06980	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E6C60_RS06985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E6C60_RS06990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E6C60_RS06995	COG1534	Rna-binding protein
E6C60_RS07000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E6C60_RS07005	COG1713	HD superfamily hydrolase involved in NAD metabolism
E6C60_RS07010	COG0799	negative regulation of ribosome biogenesis
E6C60_RS07015	COG2996	Protein conserved in bacteria
E6C60_RS07020	COG2226	methyltransferase
E6C60_RS07040	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS07040	COG2207	Transcriptional regulator
E6C60_RS07045	COG0495	leucyl-tRNA aminoacylation
E6C60_RS07050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E6C60_RS07055	COG1596	polysaccharide export
E6C60_RS07055	COG1555	photosystem II stabilization
E6C60_RS07065	COG2333	competence protein COMEC
E6C60_RS07065	COG0658	competence protein
E6C60_RS07070	COG1595	DNA-templated transcription, initiation
E6C60_RS07080	COG1466	dna polymerase III delta subunit
E6C60_RS07085	COG0268	Binds directly to 16S ribosomal RNA
E6C60_RS07090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E6C60_RS07110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C60_RS07115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E6C60_RS07115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E6C60_RS07120	COG1420	regulation of RNA biosynthetic process
E6C60_RS07125	COG0459	protein refolding
E6C60_RS07155	COG2264	protein methyltransferase activity
E6C60_RS07160	COG1994	Peptidase M50
E6C60_RS07165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E6C60_RS07170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C60_RS07180	COG1283	sodium-dependent phosphate transmembrane transporter activity
E6C60_RS07185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C60_RS07190	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E6C60_RS07195	COG1074	ATP-dependent DNA helicase activity
E6C60_RS07205	COG1074	ATP-dependent DNA helicase activity
E6C60_RS07210	COG0420	3'-5' exonuclease activity
E6C60_RS07215	COG0419	ATPase involved in DNA repair
E6C60_RS07220	COG0537	adenosine 5'-monophosphoramidase activity
E6C60_RS07225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E6C60_RS07230	COG1610	YqeY-like protein
E6C60_RS07235	COG1030	water channel activity
E6C60_RS07240	COG4864	UPF0365 protein
E6C60_RS07260	COG1702	phosphate starvation-inducible protein PhoH
E6C60_RS07265	COG1480	7TM receptor with intracellular HD hydrolase
E6C60_RS07270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E6C60_RS07275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E6C60_RS07280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E6C60_RS07290	COG1381	Involved in DNA repair and RecF pathway recombination
E6C60_RS07295	COG0752	glycyl-tRNA synthetase alpha subunit
E6C60_RS07300	COG0751	glycine-tRNA ligase activity
E6C60_RS07305	COG1671	Belongs to the UPF0178 family
E6C60_RS07310	COG0358	DNA primase activity
E6C60_RS07320	COG2384	SAM-dependent methyltransferase
E6C60_RS07325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E6C60_RS07360	COG0739	heme binding
E6C60_RS07360	COG0741	lytic transglycosylase activity
E6C60_RS07360	COG1196	nuclear chromosome segregation
E6C60_RS07365	COG1104	cysteine desulfurase activity
E6C60_RS07370	COG0301	tRNA thio-modification
E6C60_RS07375	COG0861	Integral membrane protein TerC family
E6C60_RS07385	COG1217	gtp-binding protein TYPA
E6C60_RS07400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E6C60_RS07425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C60_RS07435	COG4166	transmembrane transport
E6C60_RS07440	COG0601	transmembrane transport
E6C60_RS07445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C60_RS07450	COG0444	Belongs to the ABC transporter superfamily
E6C60_RS07455	COG4608	Belongs to the ABC transporter superfamily
E6C60_RS07460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
E6C60_RS07465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E6C60_RS07470	COG2001	Belongs to the MraZ family
E6C60_RS07475	COG0275	rRNA processing
E6C60_RS07485	COG0768	penicillin binding
E6C60_RS07490	COG0768	penicillin binding
E6C60_RS07495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C60_RS07500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E6C60_RS07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C60_RS07510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E6C60_RS07515	COG0772	Belongs to the SEDS family
E6C60_RS07520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C60_RS07525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E6C60_RS07530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C60_RS07535	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E6C60_RS07540	COG0849	cell division
E6C60_RS07545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E6C60_RS07555	COG1191	sigma factor activity
E6C60_RS07560	COG1191	sigma factor activity
E6C60_RS07565	COG1873	PFAM PRC-barrel domain
E6C60_RS07575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E6C60_RS07580	COG1799	cell septum assembly
E6C60_RS07585	COG0762	integral membrane protein
E6C60_RS07590	COG2302	S4 RNA-binding domain
E6C60_RS07595	COG3599	regulation of cell shape
E6C60_RS07610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E6C60_RS07615	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E6C60_RS07620	COG0564	pseudouridine synthase activity
E6C60_RS07625	COG0436	Aminotransferase
E6C60_RS07630	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E6C60_RS07635	COG0540	Belongs to the ATCase OTCase family
E6C60_RS07640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E6C60_RS07650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E6C60_RS07655	COG0284	orotidine-5'-phosphate decarboxylase activity
E6C60_RS07660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E6C60_RS07665	COG1131	(ABC) transporter
E6C60_RS07710	COG3546	catalase activity
E6C60_RS07715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS07760	COG3328	transposase activity
E6C60_RS07835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E6C60_RS07845	COG0628	permease
E6C60_RS07850	COG1376	ErfK ybiS ycfS ynhG family protein
E6C60_RS07860	COG2972	Histidine kinase
E6C60_RS07865	COG2207	Transcriptional regulator
E6C60_RS07865	COG4753	response regulator
E6C60_RS07870	COG1653	transport
E6C60_RS07875	COG4209	transmembrane transport
E6C60_RS07880	COG0395	ABC-type sugar transport system, permease component
E6C60_RS07895	COG0383	alpha-mannosidase activity
E6C60_RS07905	COG1376	ErfK ybiS ycfS ynhG family protein
E6C60_RS07925	COG1234	tRNA 3'-trailer cleavage
E6C60_RS07935	COG3906	Belongs to the UPF0473 family
E6C60_RS07940	COG1982	Orn Lys Arg decarboxylase major
E6C60_RS07945	COG4493	Belongs to the UPF0637 family
E6C60_RS07955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E6C60_RS07965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E6C60_RS07970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E6C60_RS07975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E6C60_RS07980	COG1832	CoA-binding protein
E6C60_RS07985	COG2190	(PTS) system
E6C60_RS07985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C60_RS07985	COG1263	PTS System
E6C60_RS07990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C60_RS07995	COG0693	protein deglycase activity
E6C60_RS08005	COG3118	belongs to the thioredoxin family
E6C60_RS08010	COG1609	Transcriptional regulator
E6C60_RS08015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C60_RS08020	COG0454	-acetyltransferase
E6C60_RS08025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C60_RS08035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E6C60_RS08040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E6C60_RS08045	COG2203	Gaf domain
E6C60_RS08045	COG2199	diguanylate cyclase activity
E6C60_RS08055	COG2309	aminopeptidase activity
E6C60_RS08065	COG4838	Belongs to the UPF0358 family
E6C60_RS08070	COG1302	Protein conserved in bacteria
E6C60_RS08075	COG0772	Belongs to the SEDS family
E6C60_RS08085	COG1473	amidohydrolase
E6C60_RS08105	COG4471	UPF0298 protein
E6C60_RS08120	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E6C60_RS08125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E6C60_RS08130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E6C60_RS08135	COG0646	methionine synthase
E6C60_RS08135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E6C60_RS08145	COG2052	Domain of unknown function (DUF370)
E6C60_RS08150	COG0194	GDP metabolic process
E6C60_RS08155	COG1758	RNA polymerase activity
E6C60_RS08160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E6C60_RS08165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E6C60_RS08170	COG0242	peptide deformylase activity
E6C60_RS08175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E6C60_RS08180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C60_RS08180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C60_RS08185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E6C60_RS08190	COG0631	protein serine/threonine phosphatase activity
E6C60_RS08195	COG0515	serine threonine protein kinase
E6C60_RS08195	COG2815	serine threonine protein kinase
E6C60_RS08200	COG1162	GTPase activity
E6C60_RS08205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E6C60_RS08215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E6C60_RS08220	COG1461	Dihydroxyacetone kinase
E6C60_RS08225	COG1307	EDD domain protein, DegV family
E6C60_RS08230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C60_RS08240	COG2135	peptidase activity
E6C60_RS08245	COG2252	PERMEase
E6C60_RS08255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C60_RS08270	COG1121	(ABC) transporter
E6C60_RS08325	COG1349	DNA-binding transcription factor activity
E6C60_RS08330	COG1105	Belongs to the carbohydrate kinase PfkB family
E6C60_RS08335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C60_RS08335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C60_RS08335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C60_RS08340	COG0673	inositol 2-dehydrogenase activity
E6C60_RS08350	COG0673	inositol 2-dehydrogenase activity
E6C60_RS08355	COG0673	inositol 2-dehydrogenase activity
E6C60_RS08395	COG0673	inositol 2-dehydrogenase activity
E6C60_RS08410	COG1216	Glycosyl transferase, family 2
E6C60_RS08440	COG4876	unkown
E6C60_RS08450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C60_RS08450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C60_RS08465	COG0861	Integral membrane protein TerC family
E6C60_RS08495	COG1733	regulation of RNA biosynthetic process
E6C60_RS08505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C60_RS08520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E6C60_RS08525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C60_RS08525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C60_RS08530	COG0803	Belongs to the bacterial solute-binding protein 9 family
E6C60_RS08535	COG1121	(ABC) transporter
E6C60_RS08540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C60_RS08545	COG0785	Cytochrome C biogenesis protein
E6C60_RS08555	COG1321	iron dependent repressor
E6C60_RS08560	COG1649	PFAM Uncharacterised BCR, COG1649
E6C60_RS08565	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C60_RS08575	COG3872	metal-dependent enzyme
E6C60_RS08585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E6C60_RS08590	COG0006	proline dipeptidase activity
E6C60_RS08595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E6C60_RS08610	COG3854	ATPases associated with a variety of cellular activities
E6C60_RS08650	COG0511	ligase activity, forming carbon-carbon bonds
E6C60_RS08655	COG0439	Biotin carboxylase
E6C60_RS08660	COG1302	Protein conserved in bacteria
E6C60_RS08675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C60_RS08680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E6C60_RS08685	COG1570	exodeoxyribonuclease VII activity
E6C60_RS08690	COG1722	exodeoxyribonuclease VII activity
E6C60_RS08695	COG0142	geranyltranstransferase activity
E6C60_RS08700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C60_RS08705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E6C60_RS08715	COG1438	arginine binding
E6C60_RS08720	COG0497	DNA recombination
E6C60_RS08725	COG0750	zinc metalloprotease
E6C60_RS08730	COG0745	RESPONSE REGULATOR receiver
E6C60_RS08745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C60_RS08750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C60_RS08755	COG0022	dehydrogenase e1 component
E6C60_RS08760	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C60_RS08765	COG0321	lipoyl(octanoyl) transferase activity
E6C60_RS08775	COG2195	Cleaves the N-terminal amino acid of tripeptides
E6C60_RS08795	COG1379	DNA repair
E6C60_RS08800	COG1300	Membrane
E6C60_RS08805	COG0735	belongs to the Fur family
E6C60_RS08815	COG4974	Belongs to the 'phage' integrase family
E6C60_RS08830	COG1686	Belongs to the peptidase S11 family
E6C60_RS08835	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C60_RS08840	COG2172	sigma factor antagonist activity
E6C60_RS08860	COG0697	spore germination
E6C60_RS08865	COG0019	diaminopimelate decarboxylase activity
E6C60_RS08870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E6C60_RS08875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C60_RS08875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C60_RS08885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C60_RS08885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C60_RS08890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E6C60_RS08895	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E6C60_RS08900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C60_RS08910	COG3874	Sporulation protein YtfJ
E6C60_RS08915	COG1686	Belongs to the peptidase S11 family
E6C60_RS08920	COG2715	membrane protein required for spore maturation
E6C60_RS08925	COG0700	Nucleoside recognition
E6C60_RS08935	COG1187	pseudouridine synthase activity
E6C60_RS08940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS08945	COG1333	cytochrome c biogenesis protein
E6C60_RS08950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C60_RS08955	COG0745	RESPONSE REGULATOR receiver
E6C60_RS08960	COG5002	protein histidine kinase activity
E6C60_RS08960	COG5002	protein histidine kinase activity
E6C60_RS08965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C60_RS08980	COG1408	metallophosphoesterase
E6C60_RS08985	COG0726	polysaccharide deacetylase
E6C60_RS08995	COG4862	establishment of competence for transformation
E6C60_RS09000	COG2339	peptidase activity
E6C60_RS09005	COG2959	enzyme of heme biosynthesis
E6C60_RS09015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E6C60_RS09020	COG0204	Acyl-transferase
E6C60_RS09025	COG0539	negative regulation of cytoplasmic translation
E6C60_RS09030	COG1160	GTP binding
E6C60_RS09035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E6C60_RS09040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E6C60_RS09060	COG2871	sodium ion transport
E6C60_RS09070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E6C60_RS09075	COG0776	regulation of translation
E6C60_RS09090	COG0142	geranyltranstransferase activity
E6C60_RS09095	COG2226	methyltransferase
E6C60_RS09100	COG0109	protoheme IX farnesyltransferase activity
E6C60_RS09105	COG0163	prenyltransferase activity
E6C60_RS09110	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E6C60_RS09120	COG0105	UTP biosynthetic process
E6C60_RS09125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C60_RS09130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C60_RS09135	COG4401	Chorismate mutase type I
E6C60_RS09145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E6C60_RS09150	COG0134	indole-3-glycerol-phosphate synthase activity
E6C60_RS09155	COG0135	phosphoribosylanthranilate isomerase activity
E6C60_RS09160	COG0133	tryptophan synthase activity
E6C60_RS09165	COG0159	tryptophan synthase activity
E6C60_RS09170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C60_RS09175	COG0287	Prephenate dehydrogenase
E6C60_RS09180	COG3344	reverse transcriptase
E6C60_RS09230	COG4347	Protein of unknown function (DUF1405)
E6C60_RS09240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS09245	COG1694	Mazg nucleotide pyrophosphohydrolase
E6C60_RS09255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E6C60_RS09260	COG1803	Methylglyoxal synthase
E6C60_RS09265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E6C60_RS09270	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS09275	COG0617	tRNA 3'-terminal CCA addition
E6C60_RS09285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E6C60_RS09290	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E6C60_RS09295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E6C60_RS09305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C60_RS09305	COG1199	ATP-dependent helicase activity
E6C60_RS09310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E6C60_RS09315	COG0402	S-adenosylhomocysteine deaminase activity
E6C60_RS09335	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C60_RS09340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C60_RS09345	COG0017	Asparaginyl-tRNA synthetase
E6C60_RS09355	COG0366	Alpha amylase catalytic
E6C60_RS09365	COG0235	Class ii aldolase
E6C60_RS09370	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
E6C60_RS09375	COG1850	ribulose-bisphosphate carboxylase activity
E6C60_RS09385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E6C60_RS09390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E6C60_RS09395	COG0436	Aminotransferase
E6C60_RS09400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C60_RS09410	COG0583	DNA-binding transcription factor activity
E6C60_RS09415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C60_RS09420	COG0066	3-isopropylmalate dehydratase activity
E6C60_RS09425	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS09435	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS09450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C60_RS09460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E6C60_RS09465	COG1132	(ABC) transporter
E6C60_RS09470	COG1132	(ABC) transporter
E6C60_RS09480	COG2340	Cysteine-rich secretory protein family
E6C60_RS09490	COG1131	(ABC) transporter
E6C60_RS09495	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E6C60_RS09500	COG0187	DNA topoisomerase II activity
E6C60_RS09505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C60_RS09515	COG0564	pseudouridine synthase activity
E6C60_RS09520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C60_RS09520	COG0116	Belongs to the methyltransferase superfamily
E6C60_RS09525	COG1193	negative regulation of DNA recombination
E6C60_RS09530	COG0791	NLP P60 protein
E6C60_RS09530	COG1388	LysM domain
E6C60_RS09545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C60_RS09550	COG0573	inorganic phosphate transmembrane transporter activity
E6C60_RS09555	COG0581	inorganic phosphate transmembrane transporter activity
E6C60_RS09560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C60_RS09565	COG0640	Transcriptional regulator
E6C60_RS09570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E6C60_RS09575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C60_RS09625	COG0463	Glycosyl transferase, family 2
E6C60_RS09660	COG0288	reversible hydration of carbon dioxide
E6C60_RS09670	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E6C60_RS09675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C60_RS09680	COG1116	anion transmembrane transporter activity
E6C60_RS09685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C60_RS09690	COG4129	membrane
E6C60_RS09705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E6C60_RS09710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E6C60_RS09715	COG2136	Putative SAM-dependent methyltransferase
E6C60_RS09715	COG2521	methyltransferase
E6C60_RS09720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E6C60_RS09725	COG1923	regulation of RNA biosynthetic process
E6C60_RS09730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E6C60_RS09745	COG0464	growth
E6C60_RS09750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C60_RS09755	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E6C60_RS09760	COG0789	Transcriptional regulator
E6C60_RS09765	COG0174	glutamine synthetase
E6C60_RS09770	COG0582	viral genome integration into host DNA
E6C60_RS09810	COG3935	DnaD domain protein
E6C60_RS09850	COG0582	viral genome integration into host DNA
E6C60_RS09985	COG5301	cellulose 1,4-beta-cellobiosidase activity
E6C60_RS10005	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS10045	COG3328	transposase activity
E6C60_RS10055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C60_RS10075	COG1011	Hydrolase
E6C60_RS10080	COG0702	epimerase
E6C60_RS10090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E6C60_RS10095	COG0646	methionine synthase
E6C60_RS10095	COG1410	methionine synthase
E6C60_RS10100	COG1234	tRNA 3'-trailer cleavage
E6C60_RS10105	COG0647	UMP catabolic process
E6C60_RS10115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E6C60_RS10125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS10130	COG1119	ATPase activity
E6C60_RS10135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E6C60_RS10140	COG0515	serine threonine protein kinase
E6C60_RS10140	COG2815	serine threonine protein kinase
E6C60_RS10190	COG0488	(ABC) transporter
E6C60_RS10195	COG0745	RESPONSE REGULATOR receiver
E6C60_RS10200	COG0791	NLP P60 protein
E6C60_RS10205	COG1564	THIamine pyrophosphokinase
E6C60_RS10210	COG2860	membrane
E6C60_RS10215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C60_RS10235	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C60_RS10245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E6C60_RS10250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C60_RS10255	COG0493	'glutamate synthase
E6C60_RS10275	COG0477	Major facilitator Superfamily
E6C60_RS10280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E6C60_RS10290	COG0745	RESPONSE REGULATOR receiver
E6C60_RS10295	COG5002	protein histidine kinase activity
E6C60_RS10305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C60_RS10310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C60_RS10315	COG0297	glycogen (starch) synthase activity
E6C60_RS10325	COG0765	amino acid transport
E6C60_RS10330	COG1126	abc transporter atp-binding protein
E6C60_RS10335	COG1388	LysM domain
E6C60_RS10335	COG3584	3D domain protein
E6C60_RS10345	COG1902	pentaerythritol trinitrate reductase activity
E6C60_RS10350	COG1842	Phage shock protein A
E6C60_RS10375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C60_RS10380	COG0805	protein transport
E6C60_RS10385	COG0303	'Molybdopterin
E6C60_RS10390	COG1763	Mo-molybdopterin cofactor biosynthetic process
E6C60_RS10405	COG0667	Aldo Keto reductase
E6C60_RS10410	COG0725	ABC transporter, periplasmic molybdate-binding protein
E6C60_RS10415	COG4149	molybdate abc transporter
E6C60_RS10450	COG4974	Belongs to the 'phage' integrase family
E6C60_RS10455	COG0039	L-malate dehydrogenase activity
E6C60_RS10460	COG1280	lysine exporter protein (LysE YggA)
E6C60_RS10495	COG1653	transport
E6C60_RS10500	COG0395	ABC-type sugar transport system, permease component
E6C60_RS10505	COG1175	transmembrane transport
E6C60_RS10510	COG3773	Cell wall hydrolase
E6C60_RS10520	COG1253	flavin adenine dinucleotide binding
E6C60_RS10545	COG2309	aminopeptidase activity
E6C60_RS10550	COG2309	aminopeptidase activity
E6C60_RS10565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E6C60_RS10575	COG1216	Glycosyl transferase, family 2
E6C60_RS10580	COG0297	glycogen (starch) synthase activity
E6C60_RS10595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C60_RS10600	COG1368	sulfuric ester hydrolase activity
E6C60_RS10605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E6C60_RS10610	COG2329	Antibiotic biosynthesis monooxygenase
E6C60_RS10615	COG2404	hydrolase activity, acting on ester bonds
E6C60_RS10620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E6C60_RS10635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C60_RS10640	COG0803	Belongs to the bacterial solute-binding protein 9 family
E6C60_RS10645	COG1121	(ABC) transporter
E6C60_RS10650	COG1321	iron dependent repressor
E6C60_RS10650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C60_RS10655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C60_RS10660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C60_RS10670	COG0142	geranyltranstransferase activity
E6C60_RS10710	COG1199	ATP-dependent helicase activity
E6C60_RS10715	COG0464	growth
E6C60_RS10725	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C60_RS10735	COG1357	PFAM Pentapeptide repeats (8 copies)
E6C60_RS10750	COG1136	(ABC) transporter
E6C60_RS10750	COG0577	efflux transmembrane transporter activity
E6C60_RS10795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E6C60_RS10820	COG5002	protein histidine kinase activity
E6C60_RS10820	COG0784	Response regulator, receiver
E6C60_RS10820	COG2205	protein histidine kinase activity
E6C60_RS10825	COG2205	protein histidine kinase activity
E6C60_RS10825	COG0784	Response regulator, receiver
E6C60_RS10825	COG2198	Histidine kinase
E6C60_RS10840	COG0425	Belongs to the sulfur carrier protein TusA family
E6C60_RS10850	COG0246	Mannitol dehydrogenase
E6C60_RS10860	COG3711	transcriptional antiterminator
E6C60_RS10885	COG0662	Cupin 2, conserved barrel domain protein
E6C60_RS10895	COG0579	oxidoreductase
E6C60_RS10900	COG0628	permease
E6C60_RS10905	COG1733	regulation of RNA biosynthetic process
E6C60_RS10910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E6C60_RS10915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E6C60_RS10920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C60_RS10930	COG1124	(ABC) transporter
E6C60_RS10935	COG0444	Belongs to the ABC transporter superfamily
E6C60_RS10940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C60_RS10945	COG0601	transmembrane transport
E6C60_RS10950	COG0747	negative chemotaxis
E6C60_RS10970	COG0515	serine threonine protein kinase
E6C60_RS10985	COG2076	Multidrug Resistance protein
E6C60_RS10995	COG1216	Glycosyl transferase, family 2
E6C60_RS11010	COG0765	amino acid transport
E6C60_RS11015	COG1253	flavin adenine dinucleotide binding
E6C60_RS11020	COG1253	flavin adenine dinucleotide binding
E6C60_RS11045	COG4589	Belongs to the CDS family
E6C60_RS11055	COG0589	response to stress
E6C60_RS11060	COG0659	secondary active sulfate transmembrane transporter activity
E6C60_RS11080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E6C60_RS11095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E6C60_RS11100	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS11110	COG3842	ATPase activity
E6C60_RS11125	COG4134	Bacterial extracellular solute-binding protein
E6C60_RS11135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C60_RS11155	COG1131	(ABC) transporter
E6C60_RS11220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E6C60_RS11230	COG0583	DNA-binding transcription factor activity
E6C60_RS11235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E6C60_RS11240	COG4191	Histidine kinase
E6C60_RS11245	COG1435	thymidine kinase activity
E6C60_RS11250	COG0398	Pfam SNARE associated Golgi protein
E6C60_RS11255	COG1320	monovalent cation:proton antiporter activity
E6C60_RS11260	COG2212	antiporter activity
E6C60_RS11265	COG1863	multisubunit Na H antiporter MnhE subunit
E6C60_RS11270	COG0651	ATP synthesis coupled electron transport
E6C60_RS11275	COG1006	Multisubunit Na H antiporter MnhC subunit
E6C60_RS11280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C60_RS11280	COG2111	Na H antiporter
E6C60_RS11295	COG4946	Tricorn protease homolog
E6C60_RS11295	COG0823	Involved in the tonB-independent uptake of proteins
E6C60_RS11295	COG1506	peptidase
E6C60_RS11305	COG1063	alcohol dehydrogenase
E6C60_RS11345	COG0803	Belongs to the bacterial solute-binding protein 9 family
E6C60_RS11350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C60_RS11355	COG1121	(ABC) transporter
E6C60_RS11360	COG1469	GTP cyclohydrolase I activity
E6C60_RS11385	COG1388	LysM domain
E6C60_RS11385	COG0791	NLP P60 protein
E6C60_RS11395	COG2133	pyrroloquinoline quinone binding
E6C60_RS11400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C60_RS11405	COG1556	Lactate utilization protein
E6C60_RS11410	COG1139	Iron-sulfur cluster binding protein
E6C60_RS11420	COG1349	DNA-binding transcription factor activity
E6C60_RS11425	COG1070	Carbohydrate kinase
E6C60_RS11430	COG4806	L-rhamnose isomerase
E6C60_RS11435	COG3347	Dehydrogenase
E6C60_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS11475	COG1227	inorganic diphosphatase activity
E6C60_RS11480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E6C60_RS11485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C60_RS11490	COG2198	Histidine kinase
E6C60_RS11490	COG5002	protein histidine kinase activity
E6C60_RS11490	COG0784	Response regulator, receiver
E6C60_RS11495	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C60_RS11520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E6C60_RS11550	COG1316	TRANSCRIPTIONal
E6C60_RS11560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E6C60_RS11585	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C60_RS11590	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS11600	COG0489	protein tyrosine kinase activity
E6C60_RS11610	COG3944	biosynthesis protein
E6C60_RS11650	COG0714	Associated with various cellular activities
E6C60_RS11665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E6C60_RS11670	COG0492	ferredoxin-NADP+ reductase activity
E6C60_RS11680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C60_RS11685	COG4120	Belongs to the binding-protein-dependent transport system permease family
E6C60_RS11695	COG1054	Belongs to the UPF0176 family
E6C60_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS11710	COG2706	6-phosphogluconolactonase activity
E6C60_RS11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C60_RS11720	COG0567	Dehydrogenase, E1 component
E6C60_RS11725	COG1801	Protein of unknown function DUF72
E6C60_RS11735	COG1280	lysine exporter protein (LysE YggA)
E6C60_RS11740	COG1113	amino acid transport
E6C60_RS11750	COG2205	protein histidine kinase activity
E6C60_RS11750	COG0784	Response regulator, receiver
E6C60_RS11760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E6C60_RS11780	COG1643	Atp-dependent helicase
E6C60_RS11785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C60_RS11790	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS11825	COG1674	ftsk spoiiie
E6C60_RS11840	COG0492	ferredoxin-NADP+ reductase activity
E6C60_RS11850	COG1132	(ABC) transporter
E6C60_RS11860	COG0494	nUDIX hydrolase
E6C60_RS11870	COG1132	(ABC) transporter
E6C60_RS11875	COG1132	(ABC) transporter
E6C60_RS11895	COG0523	cobalamin synthesis protein
E6C60_RS11900	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C60_RS11910	COG0604	alcohol dehydrogenase
E6C60_RS11915	COG3344	reverse transcriptase
E6C60_RS11920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E6C60_RS11925	COG1335	isochorismatase
E6C60_RS11935	COG4550	Control of competence regulator ComK, YlbF/YmcA
E6C60_RS11940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C60_RS11945	COG4869	propanediol catabolic process
E6C60_RS11950	COG1013	pyruvate-flavodoxin oxidoreductase activity
E6C60_RS11955	COG0674	pyruvate-flavodoxin oxidoreductase activity
E6C60_RS11955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E6C60_RS11965	COG2359	stage V sporulation protein S
E6C60_RS11970	COG1692	metallophosphoesterase
E6C60_RS11975	COG1418	mRNA catabolic process
E6C60_RS11980	COG2137	regulation of response to DNA damage stimulus
E6C60_RS11985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E6C60_RS11990	COG1058	Belongs to the CinA family
E6C60_RS11990	COG1546	Belongs to the CinA family
E6C60_RS11995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C60_RS12010	COG1426	Protein conserved in bacteria
E6C60_RS12025	COG0300	oxidoreductase activity
E6C60_RS12030	COG0612	Peptidase, M16
E6C60_RS12035	COG0612	Peptidase, M16
E6C60_RS12045	COG2721	sulfolactate sulfo-lyase activity
E6C60_RS12050	COG0246	Mannitol dehydrogenase
E6C60_RS12055	COG1904	glucuronate isomerase
E6C60_RS12060	COG2207	Transcriptional regulator
E6C60_RS12060	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS12065	COG4980	gas vesicle protein
E6C60_RS12065	COG1674	ftsk spoiiie
E6C60_RS12075	COG0740	serine-type endopeptidase activity
E6C60_RS12080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E6C60_RS12085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C60_RS12090	COG0527	aspartate kinase activity
E6C60_RS12095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C60_RS12100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E6C60_RS12105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C60_RS12110	COG0756	dUTP diphosphatase activity
E6C60_RS12115	COG0612	Peptidase, M16
E6C60_RS12120	COG0726	polysaccharide deacetylase
E6C60_RS12125	COG1185	polyribonucleotide nucleotidyltransferase activity
E6C60_RS12130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E6C60_RS12135	COG0196	riboflavin kinase activity
E6C60_RS12140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E6C60_RS12145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E6C60_RS12150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E6C60_RS12155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E6C60_RS12160	COG1358	cellular component organization or biogenesis
E6C60_RS12170	COG0195	Participates in both transcription termination and antitermination
E6C60_RS12175	COG0779	Required for maturation of 30S ribosomal subunits
E6C60_RS12180	COG2176	DNA-directed DNA polymerase activity
E6C60_RS12185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E6C60_RS12190	COG0750	zinc metalloprotease
E6C60_RS12195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E6C60_RS12200	COG4589	Belongs to the CDS family
E6C60_RS12205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E6C60_RS12210	COG0233	cytoplasmic translational termination
E6C60_RS12215	COG0528	UMP kinase activity
E6C60_RS12220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E6C60_RS12225	COG0052	Belongs to the universal ribosomal protein uS2 family
E6C60_RS12250	COG1191	sigma factor activity
E6C60_RS12260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C60_RS12265	COG1776	CheC inhibitor of MCP methylation
E6C60_RS12275	COG0643	Histidine kinase
E6C60_RS12275	COG2198	Histidine kinase
E6C60_RS12280	COG2201	protein-glutamate methylesterase activity
E6C60_RS12285	COG0455	bacterial-type flagellum organization
E6C60_RS12290	COG1419	protein localization to endoplasmic reticulum
E6C60_RS12295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C60_RS12300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C60_RS12305	COG1684	flagellar biosynthetic protein fliR
E6C60_RS12310	COG1987	bacterial-type flagellum assembly
E6C60_RS12315	COG1338	Plays a role in the flagellum-specific transport system
E6C60_RS12320	COG3190	flagellar
E6C60_RS12325	COG2201	protein-glutamate methylesterase activity
E6C60_RS12330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C60_RS12330	COG1776	CheC inhibitor of MCP methylation
E6C60_RS12335	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C60_RS12350	COG4786	Flagellar basal body rod
E6C60_RS12360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E6C60_RS12375	COG2882	bacterial-type flagellum organization
E6C60_RS12380	COG1157	protein secretion by the type III secretion system
E6C60_RS12390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C60_RS12395	COG1766	The M ring may be actively involved in energy transduction
E6C60_RS12405	COG1558	bacterial-type flagellum-dependent cell motility
E6C60_RS12410	COG1815	bacterial-type flagellum-dependent cell motility
E6C60_RS12415	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E6C60_RS12420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E6C60_RS12425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E6C60_RS12430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E6C60_RS12435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E6C60_RS12435	COG0758	DNA mediated transformation
E6C60_RS12440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E6C60_RS12445	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C60_RS12450	COG0606	chelatase, subunit chli
E6C60_RS12460	COG0318	PFAM AMP-dependent synthetase and ligase
E6C60_RS12470	COG2382	esterase
E6C60_RS12475	COG0792	nuclease activity
E6C60_RS12490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E6C60_RS12505	COG0335	large ribosomal subunit rRNA binding
E6C60_RS12510	COG0336	Belongs to the RNA methyltransferase TrmD family
E6C60_RS12515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E6C60_RS12520	COG1837	Belongs to the UPF0109 family
E6C60_RS12525	COG0228	four-way junction DNA binding
E6C60_RS12530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E6C60_RS12535	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
E6C60_RS12540	COG1272	protein, Hemolysin III
E6C60_RS12545	COG0552	protein localization to endoplasmic reticulum
E6C60_RS12550	COG1196	nuclear chromosome segregation
E6C60_RS12560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C60_RS12565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E6C60_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS12575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E6C60_RS12580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C60_RS12585	COG0416	fatty acid biosynthetic process
E6C60_RS12590	COG1349	DNA-binding transcription factor activity
E6C60_RS12595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E6C60_RS12605	COG1323	Belongs to the UPF0348 family
E6C60_RS12610	COG3480	Lon protease (S16) C-terminal proteolytic domain
E6C60_RS12615	COG3314	Sporulation integral membrane protein YlbJ
E6C60_RS12620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E6C60_RS12625	COG0742	ribosomal rna small subunit methyltransferase
E6C60_RS12640	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS12660	COG5301	cellulose 1,4-beta-cellobiosidase activity
E6C60_RS12765	COG1802	Transcriptional regulator
E6C60_RS12765	COG4626	Terminase
E6C60_RS12830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C60_RS12830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C60_RS12860	COG2002	toxin-antitoxin pair type II binding
E6C60_RS12895	COG0582	viral genome integration into host DNA
E6C60_RS12910	COG2755	lipolytic protein G-D-S-L family
E6C60_RS12915	COG1033	growth of symbiont in host cell
E6C60_RS12915	COG2409	Drug exporters of the RND superfamily
E6C60_RS12920	COG1846	Transcriptional regulator
E6C60_RS12930	COG1846	Transcriptional regulator
E6C60_RS12955	COG2211	Major facilitator Superfamily
E6C60_RS12960	COG0584	glycerophosphoryl diester phosphodiesterase
E6C60_RS12965	COG2814	Major facilitator Superfamily
E6C60_RS12970	COG0840	transmembrane signaling receptor activity
E6C60_RS12975	COG3973	AAA domain
E6C60_RS12980	COG4129	membrane
E6C60_RS12985	COG0671	phosphoesterase, PA-phosphatase related
E6C60_RS12995	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E6C60_RS13000	COG0709	Synthesizes selenophosphate from selenide and ATP
E6C60_RS13005	COG0701	Predicted permease
E6C60_RS13010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C60_RS13025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E6C60_RS13030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C60_RS13035	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E6C60_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
E6C60_RS13045	COG4604	ABC transporter, ATP-binding protein
E6C60_RS13065	COG2226	methyltransferase
E6C60_RS13070	COG0840	transmembrane signaling receptor activity
E6C60_RS13075	COG0384	phenazine biosynthesis protein PhzF
E6C60_RS13110	COG2808	Putative FMN-binding domain
E6C60_RS13115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E6C60_RS13120	COG2188	Transcriptional regulator
E6C60_RS13125	COG1263	PTS System
E6C60_RS13125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C60_RS13130	COG0366	Alpha amylase catalytic
E6C60_RS13145	COG2972	Histidine kinase
E6C60_RS13150	COG4753	response regulator
E6C60_RS13150	COG2207	Transcriptional regulator
E6C60_RS13155	COG1653	transport
E6C60_RS13160	COG0395	ABC-type sugar transport system, permease component
E6C60_RS13165	COG4209	transmembrane transport
E6C60_RS13180	COG2198	Histidine kinase
E6C60_RS13180	COG2205	protein histidine kinase activity
E6C60_RS13180	COG0784	Response regulator, receiver
E6C60_RS13210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E6C60_RS13215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E6C60_RS13260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E6C60_RS13275	COG0596	Alpha beta hydrolase
E6C60_RS13275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C60_RS13275	COG2226	methyltransferase
E6C60_RS13315	COG3344	reverse transcriptase
E6C60_RS13325	COG1278	Cold shock
E6C60_RS13355	COG3328	transposase activity
E6C60_RS13410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C60_RS13430	COG2247	cell wall binding repeat
E6C60_RS13430	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS13435	COG0840	transmembrane signaling receptor activity
E6C60_RS13440	COG2861	carbohydrate metabolic process
E6C60_RS13445	COG1733	regulation of RNA biosynthetic process
E6C60_RS13460	COG0667	Aldo Keto reductase
E6C60_RS13505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C60_RS13520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C60_RS13525	COG3949	Membrane
E6C60_RS13535	COG5001	Diguanylate cyclase
E6C60_RS13535	COG3447	MASE1 domain protein
E6C60_RS13535	COG5002	protein histidine kinase activity
E6C60_RS13540	COG0561	phosphatase activity
E6C60_RS13545	COG1187	pseudouridine synthase activity
E6C60_RS13550	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E6C60_RS13550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C60_RS13555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS13565	COG1547	Domain of unknown function (DUF309)
E6C60_RS13570	COG2357	RelA SpoT domain protein
E6C60_RS13575	COG0167	dihydroorotate dehydrogenase activity
E6C60_RS13585	COG1141	Ferredoxin
E6C60_RS13590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C60_RS13595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C60_RS13600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS13620	COG0004	ammonium transporteR
E6C60_RS13625	COG0789	Transcriptional regulator
E6C60_RS13630	COG2738	Putative neutral zinc metallopeptidase
E6C60_RS13635	COG0583	DNA-binding transcription factor activity
E6C60_RS13640	COG0705	Rhomboid family
E6C60_RS13645	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E6C60_RS13660	COG5578	integral membrane protein
E6C60_RS13670	COG0513	Belongs to the DEAD box helicase family
E6C60_RS13675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS13690	COG0534	Mate efflux family protein
E6C60_RS13725	COG1164	Oligoendopeptidase f
E6C60_RS13730	COG5416	Lipopolysaccharide assembly protein A domain
E6C60_RS13735	COG1363	Peptidase, m42
E6C60_RS13770	COG0488	(ABC) transporter
E6C60_RS13780	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C60_RS13785	COG0584	glycerophosphoryl diester phosphodiesterase
E6C60_RS13790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E6C60_RS13795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E6C60_RS13800	COG2814	Major facilitator Superfamily
E6C60_RS13810	COG0116	Belongs to the methyltransferase superfamily
E6C60_RS13820	COG4844	belongs to the
E6C60_RS13835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E6C60_RS13840	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E6C60_RS13855	COG2445	Protein of unknown function DUF86
E6C60_RS13875	COG2205	protein histidine kinase activity
E6C60_RS13890	COG0673	inositol 2-dehydrogenase activity
E6C60_RS13895	COG1082	Xylose isomerase domain protein TIM barrel
E6C60_RS13905	COG0667	Aldo Keto reductase
E6C60_RS13940	COG0704	Plays a role in the regulation of phosphate uptake
E6C60_RS13950	COG0577	efflux transmembrane transporter activity
E6C60_RS13950	COG1136	(ABC) transporter
E6C60_RS13955	COG1136	(ABC) transporter
E6C60_RS13965	COG3850	Histidine kinase
E6C60_RS13965	COG5002	protein histidine kinase activity
E6C60_RS13970	COG0745	RESPONSE REGULATOR receiver
E6C60_RS13990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C60_RS13995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E6C60_RS14005	COG0741	lytic transglycosylase activity
E6C60_RS14010	COG0237	dephospho-CoA kinase activity
E6C60_RS14015	COG1971	Probably functions as a manganese efflux pump
E6C60_RS14020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E6C60_RS14025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C60_RS14025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C60_RS14030	COG0704	Plays a role in the regulation of phosphate uptake
E6C60_RS14035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C60_RS14045	COG0745	RESPONSE REGULATOR receiver
E6C60_RS14050	COG5002	protein histidine kinase activity
E6C60_RS14055	COG0385	Bile acid
E6C60_RS14065	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS14075	COG0039	L-malate dehydrogenase activity
E6C60_RS14080	COG0538	isocitrate dehydrogenase activity
E6C60_RS14085	COG0372	Belongs to the citrate synthase family
E6C60_RS14095	COG0581	inorganic phosphate transmembrane transporter activity
E6C60_RS14100	COG0573	inorganic phosphate transmembrane transporter activity
E6C60_RS14105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C60_RS14110	COG3030	protein affecting phage T7 exclusion by the F plasmid
E6C60_RS14115	COG0824	Thioesterase
E6C60_RS14120	COG0469	pyruvate kinase activity
E6C60_RS14125	COG0825	malonyl-CoA metabolic process
E6C60_RS14130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E6C60_RS14140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E6C60_RS14145	COG0587	DNA-directed DNA polymerase activity
E6C60_RS14165	COG4109	DRTGG domain
E6C60_RS14175	COG3679	Belongs to the UPF0342 family
E6C60_RS14180	COG4399	Belongs to the UPF0754 family
E6C60_RS14185	COG0189	ligase activity
E6C60_RS14190	COG0189	ligase activity
E6C60_RS14195	COG0189	ligase activity
E6C60_RS14210	COG0189	ligase activity
E6C60_RS14220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E6C60_RS14245	COG3546	catalase activity
E6C60_RS14260	COG0535	radical SAM domain protein
E6C60_RS14265	COG2409	Drug exporters of the RND superfamily
E6C60_RS14280	COG0737	Belongs to the 5'-nucleotidase family
E6C60_RS14285	COG0314	molybdopterin synthase activity
E6C60_RS14295	COG0719	Fe-S assembly protein
E6C60_RS14300	COG0822	iron-sulfur transferase activity
E6C60_RS14305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C60_RS14310	COG0719	Fe-S assembly protein
E6C60_RS14315	COG0396	ATPase activity
E6C60_RS14320	COG0783	Belongs to the Dps family
E6C60_RS14325	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
E6C60_RS14335	COG3377	Domain of unknown function (DUF1805)
E6C60_RS14345	COG2363	Small membrane protein
E6C60_RS14355	COG3300	MHYT domain
E6C60_RS14355	COG5001	Diguanylate cyclase
E6C60_RS14380	COG3766	membrane
E6C60_RS14390	COG0395	ABC-type sugar transport system, permease component
E6C60_RS14395	COG4209	transmembrane transport
E6C60_RS14420	COG1917	Cupin 2, conserved barrel domain protein
E6C60_RS14420	COG4977	sequence-specific DNA binding
E6C60_RS14430	COG3119	arylsulfatase activity
E6C60_RS14445	COG1063	alcohol dehydrogenase
E6C60_RS14460	COG3250	beta-galactosidase activity
E6C60_RS14465	COG2718	Belongs to the UPF0229 family
E6C60_RS14470	COG3119	arylsulfatase activity
E6C60_RS14475	COG1472	Belongs to the glycosyl hydrolase 3 family
E6C60_RS14485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C60_RS14485	COG2169	Transcriptional regulator
E6C60_RS14505	COG2017	converts alpha-aldose to the beta-anomer
E6C60_RS14525	COG0395	ABC-type sugar transport system, permease component
E6C60_RS14530	COG4209	transmembrane transport
E6C60_RS14540	COG3250	beta-galactosidase activity
E6C60_RS14545	COG1012	belongs to the aldehyde dehydrogenase family
E6C60_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS14560	COG1063	alcohol dehydrogenase
E6C60_RS14565	COG4948	Mandelate Racemase Muconate Lactonizing
E6C60_RS14570	COG1414	Transcriptional regulator
E6C60_RS14585	COG4753	response regulator
E6C60_RS14585	COG2207	Transcriptional regulator
E6C60_RS14590	COG0395	ABC-type sugar transport system, permease component
E6C60_RS14595	COG1175	transmembrane transport
E6C60_RS14610	COG2207	Transcriptional regulator
E6C60_RS14610	COG4753	response regulator
E6C60_RS14615	COG2972	Histidine kinase
E6C60_RS14625	COG0653	protein targeting
E6C60_RS14700	COG0154	amidase activity
E6C60_RS14710	COG1653	transport
E6C60_RS14715	COG0395	ABC-type sugar transport system, permease component
E6C60_RS14720	COG4209	transmembrane transport
E6C60_RS14725	COG2207	Transcriptional regulator
E6C60_RS14725	COG4753	response regulator
E6C60_RS14730	COG2972	Histidine kinase
E6C60_RS14740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C60_RS14750	COG0745	RESPONSE REGULATOR receiver
E6C60_RS14755	COG2205	protein histidine kinase activity
E6C60_RS14755	COG0784	Response regulator, receiver
E6C60_RS14780	COG1940	carbohydrate kinase activity
E6C60_RS14785	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C60_RS14820	COG0778	Nitroreductase
E6C60_RS14830	COG0697	spore germination
E6C60_RS14860	COG1609	Transcriptional regulator
E6C60_RS14865	COG2323	membrane
E6C60_RS14870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C60_RS14875	COG0800	Aldolase
E6C60_RS14880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS14890	COG1307	EDD domain protein, DegV family
E6C60_RS14895	COG2205	protein histidine kinase activity
E6C60_RS14895	COG0784	Response regulator, receiver
E6C60_RS14910	COG1494	fructose-1,6-bisphosphatase
E6C60_RS14915	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
E6C60_RS14920	COG0517	IMP dehydrogenase activity
E6C60_RS14975	COG3842	ATPase activity
E6C60_RS14985	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C60_RS14990	COG2719	SpoVR family
E6C60_RS14995	COG0840	transmembrane signaling receptor activity
E6C60_RS15075	COG0305	Participates in initiation and elongation during chromosome replication
E6C60_RS15090	COG2176	DNA-directed DNA polymerase activity
E6C60_RS15095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E6C60_RS15155	COG1396	sequence-specific DNA binding
E6C60_RS15170	COG1674	ftsk spoiiie
E6C60_RS15225	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS15245	COG5301	cellulose 1,4-beta-cellobiosidase activity
E6C60_RS15340	COG0740	serine-type endopeptidase activity
E6C60_RS15400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C60_RS15415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C60_RS15435	COG2002	toxin-antitoxin pair type II binding
E6C60_RS15440	COG2357	RelA SpoT domain protein
E6C60_RS15455	COG1024	Enoyl-CoA hydratase
E6C60_RS15460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C60_RS15475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C60_RS15490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E6C60_RS15505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E6C60_RS15510	COG2972	Histidine kinase
E6C60_RS15515	COG4753	response regulator
E6C60_RS15515	COG2207	Transcriptional regulator
E6C60_RS15515	COG4753	response regulator
E6C60_RS15515	COG2207	Transcriptional regulator
E6C60_RS15525	COG0395	ABC-type sugar transport system, permease component
E6C60_RS15530	COG4209	transmembrane transport
E6C60_RS15535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E6C60_RS15540	COG5002	protein histidine kinase activity
E6C60_RS15540	COG3850	Histidine kinase
E6C60_RS15545	COG0745	RESPONSE REGULATOR receiver
E6C60_RS15550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C60_RS15555	COG2197	response regulator
E6C60_RS15560	COG4585	Histidine kinase
E6C60_RS15565	COG4758	membrane
E6C60_RS15575	COG3584	3D domain protein
E6C60_RS15580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E6C60_RS15595	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E6C60_RS15600	COG0626	cystathionine gamma-synthase activity
E6C60_RS15605	COG0626	cystathionine gamma-synthase activity
E6C60_RS15610	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E6C60_RS15615	COG0598	Magnesium transport protein CorA
E6C60_RS15630	COG1940	carbohydrate kinase activity
E6C60_RS15635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C60_RS15640	COG1393	Belongs to the ArsC family
E6C60_RS15645	COG0564	pseudouridine synthase activity
E6C60_RS15650	COG2096	Adenosyltransferase
E6C60_RS15660	COG0436	Aminotransferase
E6C60_RS15665	COG1522	sequence-specific DNA binding
E6C60_RS15680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C60_RS15685	COG3344	reverse transcriptase
E6C60_RS15695	COG3766	membrane
E6C60_RS15700	COG1193	negative regulation of DNA recombination
E6C60_RS15720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E6C60_RS15750	COG0189	ligase activity
E6C60_RS15765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C60_RS15770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C60_RS15775	COG4191	Histidine kinase
E6C60_RS15785	COG0450	alkyl hydroperoxide reductase
E6C60_RS15790	COG0473	3-isopropylmalate dehydrogenase activity
E6C60_RS15795	COG0667	Aldo Keto reductase
E6C60_RS15800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C60_RS15805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E6C60_RS15815	COG0028	Belongs to the TPP enzyme family
E6C60_RS15830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E6C60_RS15835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E6C60_RS15845	COG1215	transferase activity, transferring glycosyl groups
E6C60_RS15865	COG1242	4 iron, 4 sulfur cluster binding
E6C60_RS15870	COG0275	rRNA processing
E6C60_RS15875	COG1482	cell wall glycoprotein biosynthetic process
E6C60_RS15885	COG1032	radical SAM domain protein
E6C60_RS15890	COG0514	ATP-dependent DNA helicase (RecQ)
E6C60_RS15895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E6C60_RS15910	COG1247	-acetyltransferase
E6C60_RS15915	COG0006	proline dipeptidase activity
E6C60_RS15930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C60_RS15935	COG1120	ATPase activity
E6C60_RS15940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS15945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C60_RS15955	COG0095	Lipoate-protein ligase
E6C60_RS15965	COG0561	phosphatase activity
E6C60_RS15970	COG1234	tRNA 3'-trailer cleavage
E6C60_RS15975	COG4150	thiosulfate binding
E6C60_RS15980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C60_RS15985	COG4208	sulfate ABC transporter
E6C60_RS15995	COG0432	Pfam Uncharacterised protein family UPF0047
E6C60_RS16000	COG1309	transcriptional regulator
E6C60_RS16005	COG1739	Uncharacterized protein family UPF0029
E6C60_RS16010	COG0166	Belongs to the GPI family
E6C60_RS16040	COG0714	Associated with various cellular activities
E6C60_RS16055	COG1131	(ABC) transporter
E6C60_RS16065	COG0788	formyltetrahydrofolate deformylase activity
E6C60_RS16130	COG1525	nuclease
E6C60_RS16135	COG3011	Protein conserved in bacteria
E6C60_RS16150	COG1764	response to oxidative stress
E6C60_RS16185	COG3266	domain, Protein
E6C60_RS16185	COG1361	Conserved repeat domain
E6C60_RS16185	COG2911	Protein conserved in bacteria
E6C60_RS16190	COG0395	ABC-type sugar transport system, permease component
E6C60_RS16195	COG1175	transmembrane transport
E6C60_RS16205	COG0647	UMP catabolic process
E6C60_RS16220	COG3091	SprT-like family
E6C60_RS16235	COG2183	response to ionizing radiation
E6C60_RS16240	COG2337	Toxic component of a toxin-antitoxin (TA) module
E6C60_RS16245	COG0864	Transcriptional regulator
E6C60_RS16250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E6C60_RS16255	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E6C60_RS16260	COG1131	(ABC) transporter
E6C60_RS16285	COG1510	regulation of RNA biosynthetic process
E6C60_RS16290	COG0517	IMP dehydrogenase activity
E6C60_RS16290	COG4175	Glycine betaine
E6C60_RS16300	COG2113	Glycine betaine
E6C60_RS16305	COG0584	glycerophosphoryl diester phosphodiesterase
E6C60_RS16320	COG2323	membrane
E6C60_RS16330	COG3279	Response regulator of the LytR AlgR family
E6C60_RS16335	COG2972	Histidine kinase
E6C60_RS16335	COG0745	RESPONSE REGULATOR receiver
E6C60_RS16365	COG0459	protein refolding
E6C60_RS16370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C60_RS16375	COG3344	reverse transcriptase
E6C60_RS16380	COG0805	protein transport
E6C60_RS16385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C60_RS16390	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C60_RS16395	COG0315	cyclic pyranopterin monophosphate synthase activity
E6C60_RS16400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E6C60_RS16405	COG0488	(ABC) transporter
E6C60_RS16420	COG3119	arylsulfatase activity
E6C60_RS16430	COG1653	transport
E6C60_RS16435	COG0395	ABC-type sugar transport system, permease component
E6C60_RS16440	COG4209	transmembrane transport
E6C60_RS16445	COG2207	Transcriptional regulator
E6C60_RS16445	COG4753	response regulator
E6C60_RS16450	COG2972	Histidine kinase
E6C60_RS16455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E6C60_RS16460	COG0456	acetyltransferase
E6C60_RS16465	COG1214	PFAM Peptidase M22, glycoprotease
E6C60_RS16470	COG0802	atpase or kinase
E6C60_RS16495	COG1793	dna ligase
E6C60_RS16505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS16510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C60_RS16515	COG0739	heme binding
E6C60_RS16530	COG1132	(ABC) transporter
E6C60_RS16550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C60_RS16560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C60_RS16560	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS16565	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS16570	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS16585	COG0438	transferase activity, transferring glycosyl groups
E6C60_RS16600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E6C60_RS16605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E6C60_RS16610	COG0489	protein tyrosine kinase activity
E6C60_RS16615	COG3944	biosynthesis protein
E6C60_RS16645	COG1316	TRANSCRIPTIONal
E6C60_RS16660	COG0069	glutamate synthase activity
E6C60_RS16660	COG0067	glutamate synthase
E6C60_RS16660	COG0070	glutamate synthase
E6C60_RS16665	COG1511	domain protein
E6C60_RS16670	COG1309	transcriptional regulator
E6C60_RS16675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C60_RS16680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E6C60_RS16685	COG3773	Cell wall hydrolase
E6C60_RS16705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C60_RS16710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E6C60_RS16725	COG1396	sequence-specific DNA binding
E6C60_RS16735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C60_RS16745	COG1361	Conserved repeat domain
E6C60_RS16745	COG2911	Protein conserved in bacteria
E6C60_RS16745	COG3266	domain, Protein
E6C60_RS16750	COG3266	domain, Protein
E6C60_RS16750	COG2911	Protein conserved in bacteria
E6C60_RS16750	COG1361	Conserved repeat domain
E6C60_RS16755	COG1361	Conserved repeat domain
E6C60_RS16755	COG3266	domain, Protein
E6C60_RS16755	COG2911	Protein conserved in bacteria
E6C60_RS16765	COG1122	ATPase activity
E6C60_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS16790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C60_RS16800	COG1131	(ABC) transporter
E6C60_RS16810	COG0300	oxidoreductase activity
E6C60_RS16820	COG0583	DNA-binding transcription factor activity
E6C60_RS16830	COG1408	metallophosphoesterase
E6C60_RS16835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E6C60_RS16840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E6C60_RS16845	COG1053	succinate dehydrogenase
E6C60_RS16850	COG2009	succinate dehydrogenase
E6C60_RS16855	COG0583	DNA-binding transcription factor activity
E6C60_RS16860	COG0569	domain protein
E6C60_RS16865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E6C60_RS16875	COG0322	excinuclease ABC activity
E6C60_RS16880	COG3118	belongs to the thioredoxin family
E6C60_RS16890	COG1484	DNA-dependent DNA replication
E6C60_RS16905	COG3253	May function as heme-dependent peroxidase
E6C60_RS16910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS16915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS16920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E6C60_RS16930	COG1252	NADH dehydrogenase
E6C60_RS16945	COG0189	ligase activity
E6C60_RS16955	COG0316	Belongs to the HesB IscA family
E6C60_RS16960	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E6C60_RS16965	COG1252	NADH dehydrogenase
E6C60_RS16970	COG4844	belongs to the
E6C60_RS16975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E6C60_RS16980	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS16985	COG0644	oxidoreductase
E6C60_RS17005	COG2011	ABC-type metal ion transport system permease component
E6C60_RS17020	COG1612	heme a metabolic process
E6C60_RS17025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C60_RS17035	COG2244	polysaccharide biosynthetic process
E6C60_RS17040	COG2839	Protein conserved in bacteria
E6C60_RS17045	COG0561	phosphatase activity
E6C60_RS17070	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E6C60_RS17105	COG3093	addiction module antidote protein HigA
E6C60_RS17120	COG2346	COG2346, Truncated hemoglobins
E6C60_RS17125	COG3314	Sporulation integral membrane protein YlbJ
E6C60_RS17130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E6C60_RS17135	COG4470	Protein conserved in bacteria
E6C60_RS17140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C60_RS17145	COG0739	heme binding
E6C60_RS17155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C60_RS17160	COG0569	domain protein
E6C60_RS17170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E6C60_RS17175	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E6C60_RS17180	COG2197	response regulator
E6C60_RS17185	COG4585	Histidine kinase
E6C60_RS17195	COG1842	Phage shock protein A
E6C60_RS17205	COG1842	Phage shock protein A
E6C60_RS17320	COG0735	belongs to the Fur family
E6C60_RS17335	COG1285	pathogenesis
E6C60_RS17345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C60_RS17350	COG0154	amidase activity
E6C60_RS17355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C60_RS17375	COG1595	DNA-templated transcription, initiation
E6C60_RS17385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C60_RS17395	COG0586	Pfam SNARE associated Golgi protein
E6C60_RS17425	COG4840	Belongs to the UPF0435 family
E6C60_RS17435	COG2261	transglycosylase associated protein
E6C60_RS17450	COG0598	Magnesium transport protein CorA
E6C60_RS17455	COG1191	sigma factor activity
E6C60_RS17460	COG2172	sigma factor antagonist activity
E6C60_RS17470	COG0784	Response regulator, receiver
E6C60_RS17470	COG2205	protein histidine kinase activity
E6C60_RS17475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C60_RS17480	COG0784	Response regulator, receiver
E6C60_RS17480	COG2205	protein histidine kinase activity
E6C60_RS17480	COG5002	protein histidine kinase activity
E6C60_RS17485	COG2208	phosphoserine phosphatase activity
E6C60_RS17520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E6C60_RS17530	COG0488	(ABC) transporter
E6C60_RS17540	COG1294	oxidase, subunit
E6C60_RS17545	COG1271	oxidase subunit
E6C60_RS17550	COG1413	lyase activity
E6C60_RS17555	COG0833	amino acid
E6C60_RS17570	COG1070	Carbohydrate kinase
E6C60_RS17575	COG2115	Belongs to the xylose isomerase family
E6C60_RS17600	COG2217	Heavy metal translocating P-type atpase
E6C60_RS17605	COG3344	reverse transcriptase
E6C60_RS17620	COG0673	inositol 2-dehydrogenase activity
E6C60_RS17630	COG1131	(ABC) transporter
E6C60_RS17640	COG1595	DNA-templated transcription, initiation
E6C60_RS17655	COG3546	catalase activity
E6C60_RS17660	COG0667	Aldo Keto reductase
E6C60_RS17670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E6C60_RS17675	COG0477	Major facilitator Superfamily
E6C60_RS17680	COG3852	Histidine kinase
E6C60_RS17695	COG0351	phosphomethylpyrimidine kinase
E6C60_RS17700	COG0024	Methionine aminopeptidase
E6C60_RS17705	COG0861	Integral membrane protein TerC family
E6C60_RS17710	COG1486	melibiose metabolic process
E6C60_RS17715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C60_RS17725	COG0295	cytidine deaminase activity
E6C60_RS17730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C60_RS17735	COG0328	RNA-DNA hybrid ribonuclease activity
E6C60_RS17735	COG3341	Caulimovirus viroplasmin
E6C60_RS17750	COG2814	Major facilitator Superfamily
E6C60_RS17765	COG0445	tRNA wobble uridine modification
E6C60_RS17775	COG2207	Transcriptional regulator
E6C60_RS17775	COG4753	response regulator
E6C60_RS17785	COG3119	arylsulfatase activity
E6C60_RS17800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E6C60_RS17805	COG1653	transport
E6C60_RS17810	COG2207	Transcriptional regulator
E6C60_RS17830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C60_RS17865	COG3266	domain, Protein
E6C60_RS17865	COG2911	Protein conserved in bacteria
E6C60_RS17865	COG1361	Conserved repeat domain
E6C60_RS17870	COG1742	UPF0060 membrane protein
E6C60_RS17875	COG0494	nUDIX hydrolase
E6C60_RS17895	COG0583	DNA-binding transcription factor activity
E6C60_RS17920	COG3328	transposase activity
E6C60_RS17970	COG0732	type I restriction modification DNA specificity domain
E6C60_RS17985	COG0514	ATP-dependent DNA helicase (RecQ)
E6C60_RS17990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C60_RS18035	COG0210	DNA helicase
E6C60_RS18040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C60_RS18105	COG1396	sequence-specific DNA binding
E6C60_RS18145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E6C60_RS18150	COG4856	YbbR-like protein
E6C60_RS18155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E6C60_RS18165	COG1595	DNA-templated transcription, initiation
E6C60_RS18170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E6C60_RS18270	COG0726	polysaccharide deacetylase
E6C60_RS18290	COG0489	protein tyrosine kinase activity
E6C60_RS18295	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C60_RS18300	COG2046	Belongs to the sulfate adenylyltransferase family
E6C60_RS18305	COG0175	sulfate reduction
E6C60_RS18320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E6C60_RS18325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E6C60_RS18330	COG0101	tRNA pseudouridine synthase activity
E6C60_RS18335	COG0203	ribosomal protein L17
E6C60_RS18340	COG0202	RNA polymerase activity
E6C60_RS18345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E6C60_RS18350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E6C60_RS18355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E6C60_RS18360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E6C60_RS18370	COG0024	Methionine aminopeptidase
E6C60_RS18375	COG0563	adenylate kinase activity
E6C60_RS18380	COG0201	protein transport
E6C60_RS18385	COG0200	Binds to the 23S rRNA
E6C60_RS18390	COG1841	ribosomal large subunit assembly
E6C60_RS18395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E6C60_RS18400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E6C60_RS18405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E6C60_RS18415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E6C60_RS18420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E6C60_RS18425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E6C60_RS18430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E6C60_RS18435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E6C60_RS18440	COG0255	Belongs to the universal ribosomal protein uL29 family
E6C60_RS18445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E6C60_RS18450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E6C60_RS18455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E6C60_RS18460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E6C60_RS18465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E6C60_RS18470	COG0089	rRNA binding
E6C60_RS18475	COG0088	Forms part of the polypeptide exit tunnel
E6C60_RS18480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E6C60_RS18490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C60_RS18495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C60_RS18500	COG0049	tRNA binding
E6C60_RS18505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E6C60_RS18510	COG1358	cellular component organization or biogenesis
E6C60_RS18515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E6C60_RS18520	COG0085	RNA polymerase activity
E6C60_RS18525	COG2813	Specifically methylates the guanine in position
E6C60_RS18530	COG0222	ribosome binding
E6C60_RS18535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E6C60_RS18540	COG0081	regulation of translation
E6C60_RS18550	COG0250	Participates in transcription elongation, termination and antitermination
E6C60_RS18555	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E6C60_RS18560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E6C60_RS18570	COG3688	RNA-binding protein containing a PIN domain
E6C60_RS18575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C60_RS18580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E6C60_RS18585	COG0215	cysteine-tRNA ligase activity
E6C60_RS18590	COG1045	serine acetyltransferase
E6C60_RS18595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C60_RS18600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E6C60_RS18605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E6C60_RS18610	COG4956	integral membrane protein (PIN domain superfamily)
E6C60_RS18620	COG1183	phosphatidylcholine synthase activity
E6C60_RS18625	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E6C60_RS18630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E6C60_RS18635	COG0542	response to heat
E6C60_RS18640	COG3869	Catalyzes the specific phosphorylation of arginine residues in
E6C60_RS18645	COG3880	PFAM UvrB UvrC protein
E6C60_RS18660	COG1131	(ABC) transporter
E6C60_RS18665	COG1725	Transcriptional regulator
E6C60_RS18675	COG1131	(ABC) transporter
E6C60_RS18705	COG2223	nitrite transmembrane transporter activity
E6C60_RS18710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E6C60_RS18715	COG0210	DNA helicase
E6C60_RS18720	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
E6C60_RS18725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E6C60_RS18735	COG1215	transferase activity, transferring glycosyl groups
E6C60_RS18740	COG1091	dTDP-4-dehydrorhamnose reductase activity
E6C60_RS18755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E6C60_RS18785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C60_RS18790	COG0110	maltose O-acetyltransferase activity
E6C60_RS18805	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E6C60_RS18805	COG0662	Cupin 2, conserved barrel domain protein
E6C60_RS18825	COG2911	Protein conserved in bacteria
E6C60_RS18825	COG1361	Conserved repeat domain
E6C60_RS18825	COG3266	domain, Protein
E6C60_RS18830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E6C60_RS18835	COG3594	Acyltransferase
E6C60_RS18845	COG0826	peptidase U32
E6C60_RS18855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C60_RS18865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C60_RS18870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E6C60_RS18875	COG0556	nucleotide-excision repair
E6C60_RS18880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C60_RS18885	COG1360	Flagellar Motor Protein
E6C60_RS18905	COG0793	Belongs to the peptidase S41A family
E6C60_RS18905	COG3409	Peptidoglycan-binding domain 1 protein
E6C60_RS18910	COG0739	heme binding
E6C60_RS18915	COG2177	Part of the ABC transporter FtsEX involved in
E6C60_RS18920	COG2884	Cell division ATP-binding protein ftsE
E6C60_RS18925	COG2720	vancomycin resistance protein
E6C60_RS18945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E6C60_RS18955	COG1459	type II secretion system
E6C60_RS18965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E6C60_RS18995	COG0165	Argininosuccinate lyase
E6C60_RS19000	COG0137	argininosuccinate synthase activity
E6C60_RS19005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E6C60_RS19015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E6C60_RS19020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E6C60_RS19025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E6C60_RS19035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E6C60_RS19040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E6C60_RS19045	COG0653	protein targeting
E6C60_RS19055	COG1278	Cold shock
E6C60_RS19060	COG3328	transposase activity
E6C60_RS19065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C60_RS19075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E6C60_RS19080	COG2089	acid synthase
E6C60_RS19085	COG1083	cytidylyl-transferase
E6C60_RS19090	COG1086	Polysaccharide biosynthesis protein
E6C60_RS19110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E6C60_RS19120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C60_RS19125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E6C60_RS19130	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E6C60_RS19135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C60_RS19140	COG1256	bacterial-type flagellum assembly
E6C60_RS19140	COG4786	Flagellar basal body rod
E6C60_RS19165	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E6C60_RS19225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C60_RS19245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E6C60_RS19260	COG4786	Flagellar basal body rod
E6C60_RS19265	COG4786	Flagellar basal body rod
E6C60_RS19275	COG1609	Transcriptional regulator
E6C60_RS19285	COG2385	sporulation resulting in formation of a cellular spore
E6C60_RS19290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C60_RS19300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E6C60_RS19305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E6C60_RS19310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C60_RS19315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E6C60_RS19330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C60_RS19335	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C60_RS19350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E6C60_RS19355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E6C60_RS19360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C60_RS19370	COG0698	ribose 5-phosphate isomerase
E6C60_RS19375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C60_RS19380	COG1971	Probably functions as a manganese efflux pump
E6C60_RS19385	COG0009	L-threonylcarbamoyladenylate synthase
E6C60_RS19395	COG0772	Belongs to the SEDS family
E6C60_RS19400	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C60_RS19405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E6C60_RS19410	COG0012	GTP binding
E6C60_RS19415	COG1304	FMN binding
E6C60_RS19440	COG2076	Multidrug Resistance protein
E6C60_RS19445	COG2076	Multidrug Resistance protein
E6C60_RS19455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C60_RS19465	COG0746	molybdenum cofactor guanylyltransferase activity
E6C60_RS19475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C60_RS19480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C60_RS19485	COG2258	MOSC domain
E6C60_RS19500	COG2814	Major facilitator Superfamily
E6C60_RS19505	COG0243	molybdopterin cofactor binding
E6C60_RS19510	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C60_RS19515	COG0784	Response regulator, receiver
E6C60_RS19515	COG2205	protein histidine kinase activity
E6C60_RS19555	COG1587	Uroporphyrinogen-III synthase
E6C60_RS19560	COG0753	catalase activity
E6C60_RS19565	COG0745	RESPONSE REGULATOR receiver
E6C60_RS19575	COG3706	GGDEF domain
E6C60_RS19580	COG0667	Aldo Keto reductase
E6C60_RS19595	COG0697	spore germination
E6C60_RS19600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C60_RS19600	COG0723	plastoquinol--plastocyanin reductase activity
E6C60_RS19610	COG2252	PERMEase
E6C60_RS19620	COG1309	transcriptional regulator
E6C60_RS19625	COG1597	lipid kinase activity
E6C60_RS19630	COG4585	Histidine kinase
E6C60_RS19635	COG2197	response regulator
E6C60_RS19650	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E6C60_RS19695	COG0673	inositol 2-dehydrogenase activity
E6C60_RS19700	COG0753	catalase activity
E6C60_RS19705	COG2814	Major facilitator Superfamily
E6C60_RS19710	COG1368	sulfuric ester hydrolase activity
E6C60_RS19715	COG0252	asparaginase activity
E6C60_RS19720	COG1253	flavin adenine dinucleotide binding
E6C60_RS19755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E6C60_RS19760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C60_RS19770	COG1174	glycine betaine transport
E6C60_RS19790	COG2155	Conserved Protein
E6C60_RS19800	COG0583	DNA-binding transcription factor activity
E6C60_RS19805	COG2855	membrane
E6C60_RS19825	COG3237	CsbD-like
E6C60_RS19830	COG0386	Belongs to the glutathione peroxidase family
E6C60_RS19850	COG2966	Psort location CytoplasmicMembrane, score
E6C60_RS19855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C60_RS19860	COG2217	Heavy metal translocating P-type atpase
E6C60_RS19875	COG1312	Catalyzes the dehydration of D-mannonate
E6C60_RS19880	COG1028	Short-chain dehydrogenase reductase Sdr
E6C60_RS19890	COG0180	Tryptophanyl-tRNA synthetase
E6C60_RS19895	COG2814	Major facilitator Superfamily
E6C60_RS19900	COG1378	Sugar-specific transcriptional regulator TrmB
E6C60_RS19910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E6C60_RS19915	COG1120	ATPase activity
E6C60_RS19925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C60_RS19930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E6C60_RS19935	COG2972	Histidine kinase
E6C60_RS19935	COG0745	RESPONSE REGULATOR receiver
E6C60_RS19940	COG0492	ferredoxin-NADP+ reductase activity
E6C60_RS19945	COG1120	ATPase activity
E6C60_RS19950	COG2321	neutral zinc metallopeptidase
E6C60_RS19955	COG3119	arylsulfatase activity
E6C60_RS19965	COG2207	Transcriptional regulator
E6C60_RS19970	COG4209	transmembrane transport
E6C60_RS19975	COG0395	ABC-type sugar transport system, permease component
E6C60_RS19980	COG1653	transport
E6C60_RS19985	COG1653	transport
E6C60_RS19990	COG1653	transport
E6C60_RS19995	COG0733	neurotransmitter:sodium symporter activity
E6C60_RS20000	COG4297	protein containing double-stranded beta helix domain
E6C60_RS20015	COG0523	cobalamin synthesis protein
E6C60_RS20050	COG4989	oxidoreductase activity
E6C60_RS20055	COG5001	Diguanylate cyclase
E6C60_RS20055	COG3300	MHYT domain
E6C60_RS20065	COG1597	lipid kinase activity
E6C60_RS20070	COG2182	Extracellular solute-binding protein
E6C60_RS20075	COG2207	Transcriptional regulator
E6C60_RS20075	COG4753	response regulator
E6C60_RS20080	COG2972	Histidine kinase
E6C60_RS20085	COG3344	reverse transcriptase
E6C60_RS20105	COG3344	reverse transcriptase
E6C60_RS20110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E6C60_RS20115	COG1442	glycosyl transferase family 8
E6C60_RS20115	COG1216	Glycosyl transferase, family 2
E6C60_RS20140	COG0745	RESPONSE REGULATOR receiver
E6C60_RS20145	COG2205	protein histidine kinase activity
E6C60_RS20150	COG2205	protein histidine kinase activity
E6C60_RS20160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E6C60_RS20185	COG2084	Dehydrogenase
E6C60_RS20195	COG2610	gluconate transmembrane transporter activity
E6C60_RS20200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C60_RS20200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C60_RS20210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E6C60_RS20220	COG2022	thiamine diphosphate biosynthetic process
E6C60_RS20220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C60_RS20225	COG2022	thiamine diphosphate biosynthetic process
E6C60_RS20235	COG0352	thiamine-phosphate diphosphorylase activity
E6C60_RS20240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E6C60_RS20255	COG3403	YqcI/YcgG family
E6C60_RS20260	COG2235	arginine
E6C60_RS20265	COG5577	PFAM Coat F domain
E6C60_RS20285	COG1132	(ABC) transporter
E6C60_RS20300	COG1442	glycosyl transferase family 8
E6C60_RS20300	COG1216	Glycosyl transferase, family 2
E6C60_RS20380	COG1595	DNA-templated transcription, initiation
E6C60_RS20395	COG3706	GGDEF domain
E6C60_RS20420	COG0601	transmembrane transport
E6C60_RS20430	COG0444	Belongs to the ABC transporter superfamily
E6C60_RS20435	COG4608	Belongs to the ABC transporter superfamily
E6C60_RS20440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C60_RS20450	COG0488	(ABC) transporter
E6C60_RS20455	COG0322	excinuclease ABC activity
E6C60_RS20460	COG3708	Transcriptional regulator
E6C60_RS20460	COG2207	Transcriptional regulator
E6C60_RS20485	COG3328	transposase activity
E6C60_RS20530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C60_RS20535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E6C60_RS20550	COG5002	protein histidine kinase activity
E6C60_RS20555	COG0745	RESPONSE REGULATOR receiver
E6C60_RS20560	COG4942	peptidase
E6C60_RS20570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E6C60_RS20575	COG0305	Participates in initiation and elongation during chromosome replication
E6C60_RS20580	COG0359	binds to the 23S rRNA
E6C60_RS20585	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E6C60_RS20605	COG1316	TRANSCRIPTIONal
E6C60_RS20615	COG4608	Belongs to the ABC transporter superfamily
E6C60_RS20620	COG0444	Belongs to the ABC transporter superfamily
E6C60_RS20625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C60_RS20630	COG0601	transmembrane transport
E6C60_RS20645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E6C60_RS20650	COG0629	single-stranded DNA binding
E6C60_RS20655	COG0360	Binds together with S18 to 16S ribosomal RNA
E6C60_RS20665	COG1361	Conserved repeat domain
E6C60_RS20675	COG4481	Protein conserved in bacteria
E6C60_RS20680	COG0668	transmembrane transport
E6C60_RS20700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C60_RS20705	COG1475	DNA binding
E6C60_RS20710	COG1192	Involved in chromosome partitioning
E6C60_RS20715	COG1475	DNA binding
E6C60_RS20725	COG0445	tRNA wobble uridine modification
E6C60_RS20730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E6C60_RS20735	COG1847	R3H domain protein
E6C60_RS20750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E6C60_RS20760	COG1070	Carbohydrate kinase