locus-tag	class	description
SY83_RS00010	COG1193	negative regulation of DNA recombination
SY83_RS00030	COG3253	May function as heme-dependent peroxidase
SY83_RS00035	COG2267	carboxylic ester hydrolase activity
SY83_RS00040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SY83_RS00045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SY83_RS00050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SY83_RS00060	COG1252	NADH dehydrogenase
SY83_RS00085	COG0411	ABC transporter
SY83_RS00100	COG0189	ligase activity
SY83_RS00110	COG0316	Belongs to the HesB IscA family
SY83_RS00115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SY83_RS00120	COG1252	NADH dehydrogenase
SY83_RS00125	COG4844	belongs to the
SY83_RS00130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SY83_RS00135	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS00155	COG1612	heme a metabolic process
SY83_RS00165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SY83_RS00175	COG2244	polysaccharide biosynthetic process
SY83_RS00190	COG2839	Protein conserved in bacteria
SY83_RS00195	COG0561	phosphatase activity
SY83_RS00200	COG0367	asparagine synthase
SY83_RS00205	COG2814	Major facilitator Superfamily
SY83_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SY83_RS00220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SY83_RS00220	COG1321	iron dependent repressor
SY83_RS00225	COG1121	(ABC) transporter
SY83_RS00230	COG0803	Belongs to the bacterial solute-binding protein 9 family
SY83_RS00235	COG0768	penicillin binding
SY83_RS00255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SY83_RS00270	COG3773	Cell wall hydrolase
SY83_RS00285	COG1988	membrane-bound metal-dependent
SY83_RS00300	COG0180	Tryptophanyl-tRNA synthetase
SY83_RS00320	COG0840	transmembrane signaling receptor activity
SY83_RS00330	COG3093	addiction module antidote protein HigA
SY83_RS00345	COG2346	COG2346, Truncated hemoglobins
SY83_RS00350	COG3314	Sporulation integral membrane protein YlbJ
SY83_RS00355	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SY83_RS00365	COG4470	Protein conserved in bacteria
SY83_RS00475	COG0739	heme binding
SY83_RS00505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SY83_RS00515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SY83_RS00520	COG1082	Xylose isomerase domain protein TIM barrel
SY83_RS00525	COG2207	Transcriptional regulator
SY83_RS00530	COG0673	inositol 2-dehydrogenase activity
SY83_RS00540	COG1609	Transcriptional regulator
SY83_RS00550	COG2169	Transcriptional regulator
SY83_RS00550	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS00575	COG2207	Transcriptional regulator
SY83_RS00585	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS00585	COG2169	Transcriptional regulator
SY83_RS00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SY83_RS00600	COG0673	inositol 2-dehydrogenase activity
SY83_RS00610	COG0673	inositol 2-dehydrogenase activity
SY83_RS00615	COG1609	Transcriptional regulator
SY83_RS00620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SY83_RS00625	COG0384	phenazine biosynthesis protein PhzF
SY83_RS00630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SY83_RS00640	COG2197	response regulator
SY83_RS00645	COG4585	Histidine kinase
SY83_RS00650	COG4758	membrane
SY83_RS00655	COG1842	Phage shock protein A
SY83_RS00660	COG1983	PspC domain protein
SY83_RS00665	COG1842	Phage shock protein A
SY83_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS00680	COG2207	Transcriptional regulator
SY83_RS00680	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS00685	COG0673	inositol 2-dehydrogenase activity
SY83_RS00690	COG0673	inositol 2-dehydrogenase activity
SY83_RS00700	COG1312	Catalyzes the dehydration of D-mannonate
SY83_RS00705	COG1741	Belongs to the pirin family
SY83_RS00710	COG2259	Doxx family
SY83_RS00715	COG1733	regulation of RNA biosynthetic process
SY83_RS00835	COG0735	belongs to the Fur family
SY83_RS00850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SY83_RS00855	COG0154	amidase activity
SY83_RS00860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SY83_RS00890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SY83_RS00900	COG0586	Pfam SNARE associated Golgi protein
SY83_RS00925	COG2094	Belongs to the DNA glycosylase MPG family
SY83_RS00945	COG1294	oxidase, subunit
SY83_RS00950	COG1271	oxidase subunit
SY83_RS00955	COG2205	protein histidine kinase activity
SY83_RS00960	COG2135	peptidase activity
SY83_RS00970	COG4840	Belongs to the UPF0435 family
SY83_RS00975	COG5002	protein histidine kinase activity
SY83_RS00995	COG0514	ATP-dependent DNA helicase (RecQ)
SY83_RS01005	COG4211	Belongs to the binding-protein-dependent transport system permease family
SY83_RS01015	COG1879	ABC-type sugar transport system periplasmic component
SY83_RS01025	COG2972	Histidine kinase
SY83_RS01030	COG2207	Transcriptional regulator
SY83_RS01030	COG4753	response regulator
SY83_RS01055	COG0501	Belongs to the peptidase M48B family
SY83_RS01070	COG0395	ABC-type sugar transport system, permease component
SY83_RS01075	COG1175	transmembrane transport
SY83_RS01085	COG4753	response regulator
SY83_RS01085	COG2207	Transcriptional regulator
SY83_RS01090	COG2972	Histidine kinase
SY83_RS01105	COG0386	Belongs to the glutathione peroxidase family
SY83_RS01115	COG3693	PFAM glycoside hydrolase, family 10
SY83_RS01135	COG4608	Belongs to the ABC transporter superfamily
SY83_RS01140	COG0444	Belongs to the ABC transporter superfamily
SY83_RS01150	COG0601	transmembrane transport
SY83_RS01155	COG0747	negative chemotaxis
SY83_RS01165	COG2226	methyltransferase
SY83_RS01170	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS01185	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SY83_RS01195	COG2207	Transcriptional regulator
SY83_RS01200	COG4242	Belongs to the peptidase S51 family
SY83_RS01225	COG0251	oxidation-reduction process
SY83_RS01230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SY83_RS01240	COG1464	Belongs to the NlpA lipoprotein family
SY83_RS01255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SY83_RS01260	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SY83_RS01275	COG4715	Zinc finger, swim domain protein
SY83_RS01280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SY83_RS01285	COG0006	proline dipeptidase activity
SY83_RS01290	COG2199	diguanylate cyclase activity
SY83_RS01300	COG0747	negative chemotaxis
SY83_RS01305	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS01310	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS01315	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS01320	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS01330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SY83_RS01340	COG0444	Belongs to the ABC transporter superfamily
SY83_RS01345	COG4608	Belongs to the ABC transporter superfamily
SY83_RS01350	COG2972	Histidine kinase
SY83_RS01355	COG2207	Transcriptional regulator
SY83_RS01355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS01365	COG3871	stress protein (general stress protein 26)
SY83_RS01380	COG1653	transport
SY83_RS01385	COG0395	ABC-type sugar transport system, permease component
SY83_RS01390	COG4209	transmembrane transport
SY83_RS01395	COG2972	Histidine kinase
SY83_RS01400	COG4566	intracellular signal transduction
SY83_RS01405	COG0346	lactoylglutathione lyase activity
SY83_RS01415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SY83_RS01420	COG0445	tRNA wobble uridine modification
SY83_RS01425	COG2972	Histidine kinase
SY83_RS01430	COG2207	Transcriptional regulator
SY83_RS01430	COG4753	response regulator
SY83_RS01440	COG0395	ABC-type sugar transport system, permease component
SY83_RS01445	COG4209	transmembrane transport
SY83_RS01450	COG2207	Transcriptional regulator
SY83_RS01450	COG0662	Cupin 2, conserved barrel domain protein
SY83_RS01460	COG1653	transport
SY83_RS01465	COG0395	ABC-type sugar transport system, permease component
SY83_RS01470	COG4209	transmembrane transport
SY83_RS01495	COG0500	methyltransferase
SY83_RS01535	COG0667	Aldo Keto reductase
SY83_RS01550	COG1653	transport
SY83_RS01555	COG0395	ABC-type sugar transport system, permease component
SY83_RS01560	COG4209	transmembrane transport
SY83_RS01570	COG2972	Histidine kinase
SY83_RS01575	COG2197	response regulator
SY83_RS01590	COG0395	ABC-type sugar transport system, permease component
SY83_RS01595	COG4209	transmembrane transport
SY83_RS01600	COG2972	Histidine kinase
SY83_RS01605	COG2207	Transcriptional regulator
SY83_RS01605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS01630	COG0383	alpha-mannosidase activity
SY83_RS01705	COG1061	Type III restriction enzyme res subunit
SY83_RS01715	COG2304	oxidoreductase activity
SY83_RS01730	COG4977	sequence-specific DNA binding
SY83_RS01735	COG1309	transcriptional regulator
SY83_RS01760	COG1501	Belongs to the glycosyl hydrolase 31 family
SY83_RS01765	COG4977	sequence-specific DNA binding
SY83_RS01765	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS01795	COG1215	transferase activity, transferring glycosyl groups
SY83_RS01825	COG0791	NLP P60 protein
SY83_RS01830	COG4948	Mandelate Racemase Muconate Lactonizing
SY83_RS01835	COG1619	proteins homologs of microcin C7 resistance protein MccF
SY83_RS01840	COG4166	transmembrane transport
SY83_RS01845	COG0444	Belongs to the ABC transporter superfamily
SY83_RS01850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SY83_RS01855	COG0601	transmembrane transport
SY83_RS01860	COG2362	D-Aminopeptidase
SY83_RS01875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SY83_RS01885	COG2197	response regulator
SY83_RS01890	COG4585	Histidine kinase
SY83_RS01895	COG3239	Fatty acid desaturase
SY83_RS01905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SY83_RS01910	COG0789	Transcriptional regulator
SY83_RS01920	COG3665	Urea carboxylase-associated protein
SY83_RS01925	COG1280	lysine exporter protein (LysE YggA)
SY83_RS01930	COG3403	YqcI/YcgG family
SY83_RS01935	COG1113	amino acid transport
SY83_RS01940	COG5577	PFAM Coat F domain
SY83_RS01945	COG1063	alcohol dehydrogenase
SY83_RS01950	COG4474	Belongs to the UPF0398 family
SY83_RS01965	COG0824	Thioesterase
SY83_RS01985	COG4753	response regulator
SY83_RS01985	COG2207	Transcriptional regulator
SY83_RS01990	COG3275	phosphorelay sensor kinase activity
SY83_RS02025	COG3833	ABC-type maltose transport systems, permease component
SY83_RS02030	COG1175	transmembrane transport
SY83_RS02035	COG2182	Extracellular solute-binding protein
SY83_RS02040	COG0697	spore germination
SY83_RS02050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SY83_RS02055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SY83_RS02070	COG4753	response regulator
SY83_RS02070	COG2207	Transcriptional regulator
SY83_RS02075	COG2972	Histidine kinase
SY83_RS02080	COG0395	ABC-type sugar transport system, permease component
SY83_RS02085	COG1175	transmembrane transport
SY83_RS02095	COG0673	inositol 2-dehydrogenase activity
SY83_RS02100	COG0673	inositol 2-dehydrogenase activity
SY83_RS02115	COG0772	Belongs to the SEDS family
SY83_RS02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SY83_RS02155	COG2204	response regulator
SY83_RS02160	COG2972	Histidine kinase
SY83_RS02165	COG0395	ABC-type sugar transport system, permease component
SY83_RS02170	COG4209	transmembrane transport
SY83_RS02175	COG1653	transport
SY83_RS02190	COG3250	beta-galactosidase activity
SY83_RS02205	COG2207	Transcriptional regulator
SY83_RS02205	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS02210	COG1609	Transcriptional regulator
SY83_RS02210	COG2207	Transcriptional regulator
SY83_RS02215	COG5285	phytanoyl-CoA dioxygenase
SY83_RS02230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SY83_RS02245	COG3541	Predicted nucleotidyltransferase
SY83_RS02340	COG2801	Transposase and inactivated derivatives
SY83_RS02355	COG3481	metal-dependent phosphohydrolase, HD sub domain
SY83_RS02375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SY83_RS02385	COG1597	lipid kinase activity
SY83_RS02400	COG4496	protein, YerC YecD
SY83_RS02415	COG1012	belongs to the aldehyde dehydrogenase family
SY83_RS02420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SY83_RS02425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SY83_RS02430	COG3829	transcription factor binding
SY83_RS02435	COG0833	amino acid
SY83_RS02445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SY83_RS02455	COG1470	cell adhesion involved in biofilm formation
SY83_RS02470	COG0670	Belongs to the BI1 family
SY83_RS02475	COG0151	Belongs to the GarS family
SY83_RS02485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SY83_RS02490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SY83_RS02495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SY83_RS02500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SY83_RS02505	COG0047	phosphoribosylformylglycinamidine synthase activity
SY83_RS02510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SY83_RS02515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SY83_RS02520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SY83_RS02525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SY83_RS02530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SY83_RS02535	COG1090	epimerase
SY83_RS02570	COG2252	PERMEase
SY83_RS02575	COG2378	regulation of single-species biofilm formation
SY83_RS02580	COG2318	DinB family
SY83_RS02590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SY83_RS02590	COG0519	Catalyzes the synthesis of GMP from XMP
SY83_RS02595	COG0726	polysaccharide deacetylase
SY83_RS02600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SY83_RS02615	COG4555	ABC transporter
SY83_RS02620	COG1316	TRANSCRIPTIONal
SY83_RS02625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SY83_RS02630	COG0583	DNA-binding transcription factor activity
SY83_RS02640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SY83_RS02665	COG0483	inositol monophosphate 1-phosphatase activity
SY83_RS02670	COG0730	response to heat
SY83_RS02685	COG0489	protein tyrosine kinase activity
SY83_RS02685	COG3206	protein involved in exopolysaccharide biosynthesis
SY83_RS02690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SY83_RS02700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SY83_RS02750	COG4294	response to UV
SY83_RS02755	COG1181	Belongs to the D-alanine--D-alanine ligase family
SY83_RS02765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SY83_RS02770	COG1414	Transcriptional regulator
SY83_RS02780	COG0302	gtp cyclohydrolase
SY83_RS02795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SY83_RS02830	COG1194	a g-specific adenine glycosylase
SY83_RS02845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SY83_RS02855	COG0488	(ABC) transporter
SY83_RS02860	COG3118	belongs to the thioredoxin family
SY83_RS02870	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS02870	COG2207	Transcriptional regulator
SY83_RS02875	COG2081	HI0933 family
SY83_RS02925	COG0693	protein deglycase activity
SY83_RS02935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SY83_RS02945	COG0475	glutathione-regulated potassium exporter activity
SY83_RS02980	COG2217	Heavy metal translocating P-type atpase
SY83_RS02985	COG2608	mercury ion transmembrane transporter activity
SY83_RS02995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS03000	COG2602	Beta-lactamase
SY83_RS03010	COG0655	NAD(P)H dehydrogenase (quinone) activity
SY83_RS03020	COG1902	pentaerythritol trinitrate reductase activity
SY83_RS03035	COG2207	Transcriptional regulator
SY83_RS03040	COG2972	Histidine kinase
SY83_RS03045	COG1653	transport
SY83_RS03050	COG4209	transmembrane transport
SY83_RS03055	COG0395	ABC-type sugar transport system, permease component
SY83_RS03065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SY83_RS03070	COG3250	beta-galactosidase activity
SY83_RS03090	COG0737	Belongs to the 5'-nucleotidase family
SY83_RS03115	COG1136	(ABC) transporter
SY83_RS03165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS03180	COG2197	response regulator
SY83_RS03185	COG2972	Histidine kinase
SY83_RS03205	COG1368	sulfuric ester hydrolase activity
SY83_RS03215	COG0697	spore germination
SY83_RS03230	COG2207	Transcriptional regulator
SY83_RS03230	COG4753	response regulator
SY83_RS03245	COG3647	Membrane
SY83_RS03260	COG0395	ABC-type sugar transport system, permease component
SY83_RS03265	COG1175	transmembrane transport
SY83_RS03285	COG4209	transmembrane transport
SY83_RS03290	COG0395	ABC-type sugar transport system, permease component
SY83_RS03295	COG1653	transport
SY83_RS03310	COG3458	cephalosporin-C deacetylase activity
SY83_RS03320	COG2223	nitrite transmembrane transporter activity
SY83_RS03325	COG2814	Major facilitator Superfamily
SY83_RS03335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS03340	COG2814	Major facilitator Superfamily
SY83_RS03345	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SY83_RS03345	COG0662	Cupin 2, conserved barrel domain protein
SY83_RS03360	COG0463	Glycosyl transferase, family 2
SY83_RS03380	COG1486	melibiose metabolic process
SY83_RS03410	COG3275	phosphorelay sensor kinase activity
SY83_RS03415	COG1653	transport
SY83_RS03420	COG0395	ABC-type sugar transport system, permease component
SY83_RS03425	COG4209	transmembrane transport
SY83_RS03435	COG1509	lysine 2,3-aminomutase activity
SY83_RS03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SY83_RS03475	COG2169	Transcriptional regulator
SY83_RS03485	COG2261	transglycosylase associated protein
SY83_RS03490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SY83_RS03510	COG4999	Histidine kinase
SY83_RS03510	COG3850	Histidine kinase
SY83_RS03510	COG3437	response regulator, receiver
SY83_RS03510	COG2205	protein histidine kinase activity
SY83_RS03515	COG1486	melibiose metabolic process
SY83_RS03525	COG0395	ABC-type sugar transport system, permease component
SY83_RS03530	COG4209	transmembrane transport
SY83_RS03540	COG1070	Carbohydrate kinase
SY83_RS03545	COG1621	beta-fructofuranosidase activity
SY83_RS03560	COG1668	transmembrane transport
SY83_RS03565	COG4152	abc transporter atp-binding protein
SY83_RS03570	COG1131	(ABC) transporter
SY83_RS03595	COG1280	lysine exporter protein (LysE YggA)
SY83_RS03610	COG1741	Belongs to the pirin family
SY83_RS03620	COG3336	cytochrome c oxidase
SY83_RS03625	COG2207	Transcriptional regulator
SY83_RS03625	COG4753	response regulator
SY83_RS03630	COG2972	Histidine kinase
SY83_RS03640	COG0395	ABC-type sugar transport system, permease component
SY83_RS03650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SY83_RS03665	COG2010	Cytochrome c
SY83_RS03665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SY83_RS03685	COG1733	regulation of RNA biosynthetic process
SY83_RS03705	COG1595	DNA-templated transcription, initiation
SY83_RS03725	COG2169	Transcriptional regulator
SY83_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS03790	COG0697	spore germination
SY83_RS03795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS03805	COG0666	response to abiotic stimulus
SY83_RS03815	COG0297	glycogen (starch) synthase activity
SY83_RS03820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SY83_RS03825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SY83_RS03830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SY83_RS03850	COG2972	Histidine kinase
SY83_RS03865	COG0395	ABC-type sugar transport system, permease component
SY83_RS03870	COG1175	transmembrane transport
SY83_RS03900	COG4122	O-methyltransferase activity
SY83_RS03905	COG0583	DNA-binding transcription factor activity
SY83_RS03945	COG0456	acetyltransferase
SY83_RS03945	COG1214	PFAM Peptidase M22, glycoprotease
SY83_RS03965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS03980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SY83_RS04000	COG3118	belongs to the thioredoxin family
SY83_RS04005	COG0673	inositol 2-dehydrogenase activity
SY83_RS04010	COG2720	vancomycin resistance protein
SY83_RS04015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SY83_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SY83_RS04025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SY83_RS04030	COG3162	membrane
SY83_RS04060	COG1199	ATP-dependent helicase activity
SY83_RS04075	COG0488	(ABC) transporter
SY83_RS04080	COG1695	Transcriptional regulator
SY83_RS04085	COG2814	Major facilitator Superfamily
SY83_RS04090	COG2252	PERMEase
SY83_RS04110	COG0189	ligase activity
SY83_RS04120	COG0840	transmembrane signaling receptor activity
SY83_RS04125	COG1413	lyase activity
SY83_RS04130	COG1403	HNH endonuclease
SY83_RS04135	COG0671	phosphoesterase, PA-phosphatase related
SY83_RS04140	COG2814	Major facilitator Superfamily
SY83_RS04150	COG2211	Major facilitator Superfamily
SY83_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS04165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SY83_RS04220	COG0596	Alpha beta hydrolase
SY83_RS04225	COG2233	PERMEase
SY83_RS04230	COG1027	Aspartate ammonia-lyase
SY83_RS04235	COG1363	Peptidase, m42
SY83_RS04245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SY83_RS04255	COG0783	Belongs to the Dps family
SY83_RS04260	COG0667	Aldo Keto reductase
SY83_RS04275	COG0860	N-Acetylmuramoyl-L-alanine amidase
SY83_RS04300	COG1176	ABC-type spermidine putrescine transport system, permease component I
SY83_RS04305	COG3842	ATPase activity
SY83_RS04315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SY83_RS04320	COG0601	transmembrane transport
SY83_RS04325	COG0747	negative chemotaxis
SY83_RS04330	COG4608	Belongs to the ABC transporter superfamily
SY83_RS04335	COG0444	Belongs to the ABC transporter superfamily
SY83_RS04350	COG3345	alpha-galactosidase
SY83_RS04355	COG1653	transport
SY83_RS04360	COG2207	Transcriptional regulator
SY83_RS04360	COG4753	response regulator
SY83_RS04360	COG2207	Transcriptional regulator
SY83_RS04360	COG4753	response regulator
SY83_RS04365	COG3275	phosphorelay sensor kinase activity
SY83_RS04370	COG4209	transmembrane transport
SY83_RS04375	COG0395	ABC-type sugar transport system, permease component
SY83_RS04380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SY83_RS04410	COG1653	transport
SY83_RS04415	COG0395	ABC-type sugar transport system, permease component
SY83_RS04420	COG4209	transmembrane transport
SY83_RS04425	COG4753	response regulator
SY83_RS04425	COG2207	Transcriptional regulator
SY83_RS04430	COG2972	Histidine kinase
SY83_RS04435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SY83_RS04445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SY83_RS04465	COG1396	sequence-specific DNA binding
SY83_RS04480	COG3384	dioxygenase
SY83_RS04495	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SY83_RS04515	COG2169	Transcriptional regulator
SY83_RS04520	COG0477	Major facilitator Superfamily
SY83_RS04525	COG3835	regulator
SY83_RS04530	COG1929	Belongs to the glycerate kinase type-1 family
SY83_RS04535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SY83_RS04540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS04540	COG2207	Transcriptional regulator
SY83_RS04545	COG0445	tRNA wobble uridine modification
SY83_RS04555	COG1733	regulation of RNA biosynthetic process
SY83_RS04570	COG1725	Transcriptional regulator
SY83_RS04575	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
SY83_RS04580	COG1595	DNA-templated transcription, initiation
SY83_RS04610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SY83_RS04615	COG3209	COG3209 Rhs family protein
SY83_RS04625	COG0445	tRNA wobble uridine modification
SY83_RS04640	COG0534	Mate efflux family protein
SY83_RS04685	COG2205	protein histidine kinase activity
SY83_RS04690	COG0745	RESPONSE REGULATOR receiver
SY83_RS04695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SY83_RS04700	COG0463	Glycosyl transferase, family 2
SY83_RS04710	COG1404	Belongs to the peptidase S8 family
SY83_RS04720	COG2972	Histidine kinase
SY83_RS04725	COG4753	response regulator
SY83_RS04725	COG2207	Transcriptional regulator
SY83_RS04735	COG0395	ABC-type sugar transport system, permease component
SY83_RS04740	COG4209	transmembrane transport
SY83_RS04755	COG0395	ABC-type sugar transport system, permease component
SY83_RS04760	COG1175	transmembrane transport
SY83_RS04770	COG2972	Histidine kinase
SY83_RS04775	COG4753	response regulator
SY83_RS04775	COG2207	Transcriptional regulator
SY83_RS04785	COG2169	Transcriptional regulator
SY83_RS04785	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS04810	COG0442	prolyl-tRNA aminoacylation
SY83_RS04825	COG2972	Histidine kinase
SY83_RS04830	COG2204	response regulator
SY83_RS04835	COG4209	transmembrane transport
SY83_RS04840	COG0395	ABC-type sugar transport system, permease component
SY83_RS04845	COG1653	transport
SY83_RS04880	COG3275	phosphorelay sensor kinase activity
SY83_RS04890	COG1653	transport
SY83_RS04895	COG4209	transmembrane transport
SY83_RS04900	COG0395	ABC-type sugar transport system, permease component
SY83_RS04905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SY83_RS04925	COG3832	glyoxalase III activity
SY83_RS04930	COG0025	NhaP-type Na H and K H
SY83_RS04950	COG1063	alcohol dehydrogenase
SY83_RS04965	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SY83_RS04970	COG2207	Transcriptional regulator
SY83_RS04975	COG4209	transmembrane transport
SY83_RS04980	COG0395	ABC-type sugar transport system, permease component
SY83_RS04985	COG1653	transport
SY83_RS04995	COG1132	(ABC) transporter
SY83_RS05000	COG1132	(ABC) transporter
SY83_RS05035	COG0300	oxidoreductase activity
SY83_RS05045	COG0640	Transcriptional regulator
SY83_RS05060	COG4977	sequence-specific DNA binding
SY83_RS05060	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS05070	COG4303	Ethanolamine ammonia lyase large subunit
SY83_RS05075	COG2972	Histidine kinase
SY83_RS05080	COG4753	response regulator
SY83_RS05080	COG2207	Transcriptional regulator
SY83_RS05090	COG0395	ABC-type sugar transport system, permease component
SY83_RS05095	COG4209	transmembrane transport
SY83_RS05105	COG4209	transmembrane transport
SY83_RS05110	COG0395	ABC-type sugar transport system, permease component
SY83_RS05115	COG1653	transport
SY83_RS05120	COG2169	Transcriptional regulator
SY83_RS05140	COG1472	Belongs to the glycosyl hydrolase 3 family
SY83_RS05155	COG0697	spore germination
SY83_RS05160	COG1733	regulation of RNA biosynthetic process
SY83_RS05170	COG3546	catalase activity
SY83_RS05185	COG1193	negative regulation of DNA recombination
SY83_RS05200	COG4941	Belongs to the sigma-70 factor family
SY83_RS05225	COG0840	transmembrane signaling receptor activity
SY83_RS05225	COG5278	phosphoserine phosphatase activity
SY83_RS05235	COG4209	transmembrane transport
SY83_RS05240	COG0395	ABC-type sugar transport system, permease component
SY83_RS05250	COG5520	Belongs to the glycosyl hydrolase 30 family
SY83_RS05280	COG0395	ABC-type sugar transport system, permease component
SY83_RS05285	COG1175	transmembrane transport
SY83_RS05300	COG2972	Histidine kinase
SY83_RS05305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SY83_RS05315	COG4948	Mandelate Racemase Muconate Lactonizing
SY83_RS05320	COG1063	alcohol dehydrogenase
SY83_RS05325	COG0473	3-isopropylmalate dehydrogenase activity
SY83_RS05325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SY83_RS05330	COG1414	Transcriptional regulator
SY83_RS05335	COG3386	PFAM SMP-30 Gluconolaconase
SY83_RS05340	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SY83_RS05365	COG3639	organic phosphonate transmembrane transporter activity
SY83_RS05370	COG3639	organic phosphonate transmembrane transporter activity
SY83_RS05375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SY83_RS05390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SY83_RS05390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SY83_RS05395	COG1349	DNA-binding transcription factor activity
SY83_RS05405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SY83_RS05445	COG0583	DNA-binding transcription factor activity
SY83_RS05460	COG1476	TRANSCRIPTIONal
SY83_RS05630	COG0592	DNA-directed DNA polymerase activity
SY83_RS05655	COG0346	lactoylglutathione lyase activity
SY83_RS05680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SY83_RS05690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SY83_RS05695	COG5662	AntiSigma factor
SY83_RS05700	COG1595	DNA-templated transcription, initiation
SY83_RS05705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SY83_RS05810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SY83_RS05815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SY83_RS05820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SY83_RS05825	COG3852	Histidine kinase
SY83_RS05840	COG0254	rRNA binding
SY83_RS05850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SY83_RS05855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SY83_RS05860	COG0191	fructose-bisphosphate aldolase activity
SY83_RS05870	COG0504	CTP synthase activity
SY83_RS05875	COG3343	RNA polymerase activity
SY83_RS05880	COG1404	Belongs to the peptidase S8 family
SY83_RS05885	COG0018	arginyl-trna synthetase
SY83_RS05895	COG0697	spore germination
SY83_RS05915	COG3119	arylsulfatase activity
SY83_RS05920	COG3119	arylsulfatase activity
SY83_RS05930	COG0395	ABC-type sugar transport system, permease component
SY83_RS05950	COG0395	ABC-type sugar transport system, permease component
SY83_RS05955	COG4209	transmembrane transport
SY83_RS05965	COG1082	Xylose isomerase domain protein TIM barrel
SY83_RS05970	COG0673	inositol 2-dehydrogenase activity
SY83_RS05975	COG1082	Xylose isomerase domain protein TIM barrel
SY83_RS05990	COG0010	Belongs to the arginase family
SY83_RS05995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SY83_RS06000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SY83_RS06010	COG0791	NLP P60 protein
SY83_RS06030	COG0791	NLP P60 protein
SY83_RS06035	COG0415	Belongs to the DNA photolyase family
SY83_RS06040	COG0708	Exodeoxyribonuclease III
SY83_RS06050	COG1132	(ABC) transporter
SY83_RS06075	COG0477	Major facilitator Superfamily
SY83_RS06110	COG0504	CTP synthase activity
SY83_RS06145	COG2207	Transcriptional regulator
SY83_RS06175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SY83_RS06190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SY83_RS06195	COG1360	Flagellar Motor Protein
SY83_RS06200	COG1187	pseudouridine synthase activity
SY83_RS06205	COG5002	protein histidine kinase activity
SY83_RS06210	COG0590	tRNA wobble adenosine to inosine editing
SY83_RS06225	COG0598	Magnesium transport protein CorA
SY83_RS06235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SY83_RS06245	COG2814	Major facilitator Superfamily
SY83_RS06255	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SY83_RS06275	COG0517	IMP dehydrogenase activity
SY83_RS06275	COG0516	GMP reductase activity
SY83_RS06280	COG2356	endonuclease I
SY83_RS06315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SY83_RS06320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SY83_RS06325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SY83_RS06330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SY83_RS06335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SY83_RS06340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SY83_RS06345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SY83_RS06350	COG0512	Glutamine amidotransferase of anthranilate synthase
SY83_RS06355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SY83_RS06360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SY83_RS06375	COG0157	Belongs to the NadC ModD family
SY83_RS06380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SY83_RS06385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SY83_RS06390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SY83_RS06400	COG0037	tRNA processing
SY83_RS06405	COG0515	serine threonine protein kinase
SY83_RS06410	COG2304	oxidoreductase activity
SY83_RS06415	COG2208	phosphoserine phosphatase activity
SY83_RS06425	COG1098	S1 RNA binding domain
SY83_RS06445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SY83_RS06450	COG0776	regulation of translation
SY83_RS06455	COG3956	TIGRFAM MazG family protein
SY83_RS06460	COG2244	polysaccharide biosynthetic process
SY83_RS06465	COG2002	toxin-antitoxin pair type II binding
SY83_RS06475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SY83_RS06485	COG0193	aminoacyl-tRNA hydrolase activity
SY83_RS06495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SY83_RS06500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SY83_RS06505	COG2088	sporulation resulting in formation of a cellular spore
SY83_RS06510	COG0251	oxidation-reduction process
SY83_RS06515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SY83_RS06520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SY83_RS06530	COG4466	Protein conserved in bacteria
SY83_RS06540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SY83_RS06550	COG3584	3D domain protein
SY83_RS06555	COG0084	hydrolase, TatD family'
SY83_RS06560	COG1078	dGTPase activity
SY83_RS06565	COG2002	toxin-antitoxin pair type II binding
SY83_RS06570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SY83_RS06575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SY83_RS06580	COG4467	Involved in initiation control of chromosome replication
SY83_RS06585	COG1774	PSP1 C-terminal conserved region
SY83_RS06590	COG0470	DNA polymerase III
SY83_RS06595	COG1728	Protein conserved in bacteria
SY83_RS06600	COG3870	Protein conserved in bacteria
SY83_RS06605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SY83_RS06610	COG1982	Orn Lys Arg decarboxylase major
SY83_RS06645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SY83_RS06650	COG0187	DNA topoisomerase II activity
SY83_RS06660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SY83_RS06665	COG2501	S4 domain
SY83_RS06670	COG0592	DNA-directed DNA polymerase activity
SY83_RS06675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SY83_RS06680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SY83_RS06685	COG0594	ribonuclease P activity
SY83_RS06690	COG0706	membrane insertase activity
SY83_RS06695	COG1847	R3H domain protein
SY83_RS06700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SY83_RS06705	COG0445	tRNA wobble uridine modification
SY83_RS06710	COG0357	Ribosomal RNA small subunit methyltransferase G
SY83_RS06715	COG1475	DNA binding
SY83_RS06720	COG1192	Involved in chromosome partitioning
SY83_RS06725	COG1475	DNA binding
SY83_RS06730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SY83_RS06750	COG0668	transmembrane transport
SY83_RS06755	COG4481	Protein conserved in bacteria
SY83_RS06770	COG0360	Binds together with S18 to 16S ribosomal RNA
SY83_RS06775	COG0629	single-stranded DNA binding
SY83_RS06780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SY83_RS06785	COG0784	Response regulator, receiver
SY83_RS06785	COG2205	protein histidine kinase activity
SY83_RS06800	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SY83_RS06805	COG0359	binds to the 23S rRNA
SY83_RS06810	COG0305	Participates in initiation and elongation during chromosome replication
SY83_RS06815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SY83_RS06840	COG5002	protein histidine kinase activity
SY83_RS06855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SY83_RS06865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SY83_RS06905	COG1216	Glycosyl transferase, family 2
SY83_RS06930	COG1968	undecaprenyl-diphosphatase activity
SY83_RS06935	COG1404	Belongs to the peptidase S8 family
SY83_RS06940	COG1285	pathogenesis
SY83_RS06960	COG2197	response regulator
SY83_RS06980	COG0395	ABC-type sugar transport system, permease component
SY83_RS06985	COG4209	transmembrane transport
SY83_RS06990	COG2207	Transcriptional regulator
SY83_RS06990	COG4753	response regulator
SY83_RS07015	COG1937	Protein conserved in bacteria
SY83_RS07025	COG2814	Major facilitator Superfamily
SY83_RS07035	COG4977	sequence-specific DNA binding
SY83_RS07035	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SY83_RS07055	COG0438	transferase activity, transferring glycosyl groups
SY83_RS07065	COG1086	Polysaccharide biosynthesis protein
SY83_RS07080	COG1216	Glycosyl transferase, family 2
SY83_RS07085	COG1024	Enoyl-CoA hydratase
SY83_RS07100	COG0202	RNA polymerase activity
SY83_RS07155	COG0463	Glycosyl transferase, family 2
SY83_RS07180	COG1215	transferase activity, transferring glycosyl groups
SY83_RS07190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SY83_RS07200	COG0438	transferase activity, transferring glycosyl groups
SY83_RS07210	COG2032	superoxide dismutase activity
SY83_RS07220	COG0840	transmembrane signaling receptor activity
SY83_RS07240	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SY83_RS07245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SY83_RS07260	COG0688	phosphatidylethanolamine metabolic process
SY83_RS07265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SY83_RS07270	COG3344	reverse transcriptase
SY83_RS07315	COG2378	regulation of single-species biofilm formation
SY83_RS07325	COG1309	transcriptional regulator
SY83_RS07330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SY83_RS07340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SY83_RS07350	COG1263	PTS System
SY83_RS07350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SY83_RS07350	COG2190	(PTS) system
SY83_RS07355	COG4473	ABC transporter
SY83_RS07360	COG1131	(ABC) transporter
SY83_RS07370	COG0300	oxidoreductase activity
SY83_RS07385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SY83_RS07465	COG0300	oxidoreductase activity
SY83_RS07470	COG1406	Chemotaxis phosphatase CheX
SY83_RS07475	COG2270	Major facilitator Superfamily
SY83_RS07480	COG0583	DNA-binding transcription factor activity
SY83_RS07515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SY83_RS07520	COG1053	succinate dehydrogenase
SY83_RS07525	COG2009	succinate dehydrogenase
SY83_RS07530	COG0583	DNA-binding transcription factor activity
SY83_RS07540	COG0569	domain protein
SY83_RS07545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SY83_RS07555	COG0322	excinuclease ABC activity
SY83_RS07560	COG2207	Transcriptional regulator
SY83_RS07570	COG3118	belongs to the thioredoxin family
SY83_RS07575	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
SY83_RS07585	COG0395	ABC-type sugar transport system, permease component
SY83_RS07590	COG4209	transmembrane transport
SY83_RS07595	COG3275	phosphorelay sensor kinase activity
SY83_RS07630	COG4753	response regulator
SY83_RS07630	COG2207	Transcriptional regulator
SY83_RS07640	COG1404	Belongs to the peptidase S8 family
SY83_RS07640	COG4412	M6 family metalloprotease domain protein
SY83_RS07645	COG1484	DNA-dependent DNA replication
SY83_RS07655	COG0300	oxidoreductase activity
SY83_RS07665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SY83_RS07675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SY83_RS07685	COG3237	CsbD-like
SY83_RS07695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SY83_RS07705	COG2814	Major facilitator Superfamily
SY83_RS07715	COG0667	Aldo Keto reductase
SY83_RS07725	COG0789	Transcriptional regulator
SY83_RS07745	COG1131	(ABC) transporter
SY83_RS07750	COG1725	Transcriptional regulator
SY83_RS07755	COG1253	flavin adenine dinucleotide binding
SY83_RS07765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SY83_RS07775	COG2197	response regulator
SY83_RS07780	COG4585	Histidine kinase
SY83_RS07795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SY83_RS07800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SY83_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS07815	COG1063	alcohol dehydrogenase
SY83_RS07820	COG1082	Xylose isomerase domain protein TIM barrel
SY83_RS07830	COG0673	inositol 2-dehydrogenase activity
SY83_RS07845	COG5566	PFAM Mor transcription activator
SY83_RS07880	COG1122	ATPase activity
SY83_RS07895	COG0010	Belongs to the arginase family
SY83_RS07905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SY83_RS07915	COG1704	LemA family
SY83_RS07935	COG1129	ABC transporter
SY83_RS07945	COG0559	Belongs to the binding-protein-dependent transport system permease family
SY83_RS07955	COG0831	urea catabolic process
SY83_RS07960	COG0832	Belongs to the urease beta subunit family
SY83_RS07965	COG0804	urea catabolic process
SY83_RS07970	COG0830	nickel cation binding
SY83_RS07975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SY83_RS07980	COG0829	nickel cation binding
SY83_RS07990	COG1349	DNA-binding transcription factor activity
SY83_RS08000	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SY83_RS08005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SY83_RS08005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SY83_RS08015	COG3842	ATPase activity
SY83_RS08020	COG1840	ABC-type Fe3 transport system, periplasmic component
SY83_RS08025	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SY83_RS08055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SY83_RS08075	COG1733	regulation of RNA biosynthetic process
SY83_RS08080	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SY83_RS08085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SY83_RS08090	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SY83_RS08095	COG0765	amino acid transport
SY83_RS08100	COG0765	amino acid transport
SY83_RS08105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SY83_RS08110	COG1126	abc transporter atp-binding protein
SY83_RS08120	COG5434	Belongs to the glycosyl hydrolase 28 family
SY83_RS08125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SY83_RS08130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SY83_RS08135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SY83_RS08145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SY83_RS08155	COG1216	Glycosyl transferase, family 2
SY83_RS08175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SY83_RS08175	COG0463	Glycosyl transferase, family 2
SY83_RS08180	COG0438	transferase activity, transferring glycosyl groups
SY83_RS08185	COG1216	Glycosyl transferase, family 2
SY83_RS08190	COG0438	transferase activity, transferring glycosyl groups
SY83_RS08195	COG1086	Polysaccharide biosynthesis protein
SY83_RS08200	COG0489	protein tyrosine kinase activity
SY83_RS08205	COG3944	biosynthesis protein
SY83_RS08230	COG1408	metallophosphoesterase
SY83_RS08240	COG2186	Transcriptional regulator
SY83_RS08245	COG1556	Lactate utilization protein
SY83_RS08250	COG1139	Iron-sulfur cluster binding protein
SY83_RS08255	COG0247	lactate metabolic process
SY83_RS08260	COG1349	DNA-binding transcription factor activity
SY83_RS08265	COG1070	Carbohydrate kinase
SY83_RS08270	COG4952	isomerase
SY83_RS08275	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS08275	COG3347	Dehydrogenase
SY83_RS08295	COG2972	Histidine kinase
SY83_RS08300	COG4753	response regulator
SY83_RS08300	COG2207	Transcriptional regulator
SY83_RS08305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SY83_RS08315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SY83_RS08320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SY83_RS08325	COG1191	sigma factor activity
SY83_RS08365	COG0450	alkyl hydroperoxide reductase
SY83_RS08380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SY83_RS08385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SY83_RS08390	COG0440	acetolactate synthase activity
SY83_RS08395	COG0028	Belongs to the TPP enzyme family
SY83_RS08410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SY83_RS08415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SY83_RS08420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SY83_RS08425	COG1215	transferase activity, transferring glycosyl groups
SY83_RS08430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SY83_RS08430	COG0438	transferase activity, transferring glycosyl groups
SY83_RS08435	COG0671	phosphoesterase, PA-phosphatase related
SY83_RS08440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SY83_RS08470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SY83_RS08475	COG1242	4 iron, 4 sulfur cluster binding
SY83_RS08485	COG0346	lactoylglutathione lyase activity
SY83_RS08490	COG1482	cell wall glycoprotein biosynthetic process
SY83_RS08535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SY83_RS08550	COG0697	spore germination
SY83_RS08580	COG0351	phosphomethylpyrimidine kinase
SY83_RS08585	COG2022	thiamine diphosphate biosynthetic process
SY83_RS08595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SY83_RS08645	COG2318	DinB family
SY83_RS08655	COG2207	Transcriptional regulator
SY83_RS08675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SY83_RS08680	COG4326	sporulation control protein
SY83_RS08685	COG1309	transcriptional regulator
SY83_RS08690	COG1739	Uncharacterized protein family UPF0029
SY83_RS08695	COG0166	Belongs to the GPI family
SY83_RS08700	COG2084	Dehydrogenase
SY83_RS08705	COG3123	guanosine phosphorylase activity
SY83_RS08715	COG0788	formyltetrahydrofolate deformylase activity
SY83_RS08720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SY83_RS08735	COG1073	alpha beta
SY83_RS08740	COG1388	LysM domain
SY83_RS08740	COG0791	NLP P60 protein
SY83_RS08745	COG0210	DNA helicase
SY83_RS08750	COG3011	Protein conserved in bacteria
SY83_RS08755	COG2197	response regulator
SY83_RS08760	COG5002	protein histidine kinase activity
SY83_RS08765	COG3871	stress protein (general stress protein 26)
SY83_RS08790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SY83_RS08795	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SY83_RS08800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SY83_RS08805	COG1492	cobalamin metabolic process
SY83_RS08810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SY83_RS08815	COG1120	ATPase activity
SY83_RS08820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SY83_RS08825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS08835	COG3250	beta-galactosidase activity
SY83_RS08845	COG0655	NAD(P)H dehydrogenase (quinone) activity
SY83_RS08860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SY83_RS08870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SY83_RS08875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SY83_RS08880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SY83_RS08900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS08905	COG0456	acetyltransferase
SY83_RS08915	COG1473	amidohydrolase
SY83_RS08920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS08925	COG1126	abc transporter atp-binding protein
SY83_RS08930	COG0765	amino acid transport
SY83_RS08935	COG0765	amino acid transport
SY83_RS08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SY83_RS08945	COG0583	DNA-binding transcription factor activity
SY83_RS08950	COG1657	PFAM Prenyltransferase squalene oxidase
SY83_RS08975	COG0438	transferase activity, transferring glycosyl groups
SY83_RS08980	COG0438	transferase activity, transferring glycosyl groups
SY83_RS08995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SY83_RS09000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SY83_RS09005	COG0489	protein tyrosine kinase activity
SY83_RS09010	COG3944	biosynthesis protein
SY83_RS09015	COG1396	sequence-specific DNA binding
SY83_RS09025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS09035	COG0395	ABC-type sugar transport system, permease component
SY83_RS09040	COG4209	transmembrane transport
SY83_RS09045	COG2207	Transcriptional regulator
SY83_RS09050	COG3275	phosphorelay sensor kinase activity
SY83_RS09060	COG2207	Transcriptional regulator
SY83_RS09075	COG1737	Transcriptional regulator
SY83_RS09085	COG1175	transmembrane transport
SY83_RS09090	COG1653	transport
SY83_RS09095	COG2197	response regulator
SY83_RS09110	COG2972	Histidine kinase
SY83_RS09110	COG0745	RESPONSE REGULATOR receiver
SY83_RS09130	COG0784	Response regulator, receiver
SY83_RS09130	COG2205	protein histidine kinase activity
SY83_RS09130	COG5002	protein histidine kinase activity
SY83_RS09135	COG2972	Histidine kinase
SY83_RS09140	COG4753	response regulator
SY83_RS09140	COG2207	Transcriptional regulator
SY83_RS09150	COG0395	ABC-type sugar transport system, permease component
SY83_RS09155	COG4209	transmembrane transport
SY83_RS09185	COG2207	Transcriptional regulator
SY83_RS09185	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS09200	COG1653	transport
SY83_RS09205	COG0395	ABC-type sugar transport system, permease component
SY83_RS09210	COG4209	transmembrane transport
SY83_RS09225	COG3693	PFAM glycoside hydrolase, family 10
SY83_RS09230	COG1653	transport
SY83_RS09235	COG0395	ABC-type sugar transport system, permease component
SY83_RS09240	COG4209	transmembrane transport
SY83_RS09245	COG2207	Transcriptional regulator
SY83_RS09245	COG4753	response regulator
SY83_RS09245	COG2207	Transcriptional regulator
SY83_RS09245	COG4753	response regulator
SY83_RS09250	COG2972	Histidine kinase
SY83_RS09260	COG3345	alpha-galactosidase
SY83_RS09280	COG1309	transcriptional regulator
SY83_RS09335	COG0488	(ABC) transporter
SY83_RS09340	COG1554	hydrolase, family 65, central catalytic
SY83_RS09345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SY83_RS09395	COG0110	maltose O-acetyltransferase activity
SY83_RS09430	COG3708	Transcriptional regulator
SY83_RS09430	COG2207	Transcriptional regulator
SY83_RS09435	COG4753	response regulator
SY83_RS09435	COG2207	Transcriptional regulator
SY83_RS09445	COG4209	transmembrane transport
SY83_RS09450	COG0395	ABC-type sugar transport system, permease component
SY83_RS09460	COG0861	Integral membrane protein TerC family
SY83_RS09470	COG1395	domain, Protein
SY83_RS09480	COG1131	(ABC) transporter
SY83_RS09495	COG2409	Drug exporters of the RND superfamily
SY83_RS09525	COG0778	Nitroreductase
SY83_RS09530	COG1620	l-lactate permease
SY83_RS09535	COG0039	L-malate dehydrogenase activity
SY83_RS09550	COG1136	(ABC) transporter
SY83_RS09555	COG0577	efflux transmembrane transporter activity
SY83_RS09565	COG2205	protein histidine kinase activity
SY83_RS09570	COG0745	RESPONSE REGULATOR receiver
SY83_RS09595	COG1309	transcriptional regulator
SY83_RS09600	COG2814	Major facilitator Superfamily
SY83_RS09605	COG1846	Transcriptional regulator
SY83_RS09610	COG2814	Major facilitator Superfamily
SY83_RS09615	COG0513	Belongs to the DEAD box helicase family
SY83_RS09645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SY83_RS09655	COG0189	ligase activity
SY83_RS09680	COG2197	response regulator
SY83_RS09685	COG2203	Gaf domain
SY83_RS09685	COG4585	Histidine kinase
SY83_RS09690	COG2197	response regulator
SY83_RS09695	COG3437	response regulator, receiver
SY83_RS09695	COG2770	Histidine kinase
SY83_RS09700	COG2169	Transcriptional regulator
SY83_RS09700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SY83_RS09705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SY83_RS09715	COG0583	DNA-binding transcription factor activity
SY83_RS09725	COG2321	neutral zinc metallopeptidase
SY83_RS09730	COG0745	RESPONSE REGULATOR receiver
SY83_RS09735	COG2205	protein histidine kinase activity
SY83_RS09740	COG1131	(ABC) transporter
SY83_RS09760	COG3655	Transcriptional regulator
SY83_RS09805	COG0322	excinuclease ABC activity
SY83_RS09820	COG1132	(ABC) transporter
SY83_RS09825	COG1132	(ABC) transporter
SY83_RS09825	COG1132	(ABC) transporter
SY83_RS09850	COG0778	Nitroreductase
SY83_RS09855	COG1764	response to oxidative stress
SY83_RS09900	COG2211	Major facilitator Superfamily
SY83_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS09950	COG2207	Transcriptional regulator
SY83_RS09950	COG1609	Transcriptional regulator
SY83_RS09955	COG2972	Histidine kinase
SY83_RS09960	COG2207	Transcriptional regulator
SY83_RS09960	COG4753	response regulator
SY83_RS09965	COG1653	transport
SY83_RS09970	COG1175	transmembrane transport
SY83_RS09975	COG0395	ABC-type sugar transport system, permease component
SY83_RS09980	COG2081	HI0933 family
SY83_RS09995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SY83_RS10015	COG0517	IMP dehydrogenase activity
SY83_RS10015	COG1125	glycine betaine transport
SY83_RS10020	COG1174	glycine betaine transport
SY83_RS10030	COG3226	Transcriptional regulator
SY83_RS10040	COG2508	Transcriptional regulator
SY83_RS10045	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS10055	COG0559	Belongs to the binding-protein-dependent transport system permease family
SY83_RS10070	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS10080	COG0438	transferase activity, transferring glycosyl groups
SY83_RS10085	COG1902	pentaerythritol trinitrate reductase activity
SY83_RS10110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SY83_RS10120	COG0667	Aldo Keto reductase
SY83_RS10125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SY83_RS10130	COG1132	(ABC) transporter
SY83_RS10145	COG0745	RESPONSE REGULATOR receiver
SY83_RS10150	COG0386	Belongs to the glutathione peroxidase family
SY83_RS10155	COG1846	Transcriptional regulator
SY83_RS10165	COG1846	Transcriptional regulator
SY83_RS10170	COG2409	Drug exporters of the RND superfamily
SY83_RS10170	COG1033	growth of symbiont in host cell
SY83_RS10180	COG2814	Major facilitator Superfamily
SY83_RS10200	COG2972	Histidine kinase
SY83_RS10205	COG2197	response regulator
SY83_RS10215	COG4209	transmembrane transport
SY83_RS10220	COG0395	ABC-type sugar transport system, permease component
SY83_RS10240	COG2132	Multicopper oxidase
SY83_RS10245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SY83_RS10250	COG1309	transcriptional regulator
SY83_RS10270	COG1597	lipid kinase activity
SY83_RS10310	COG1725	Transcriptional regulator
SY83_RS10315	COG1131	(ABC) transporter
SY83_RS10330	COG1131	(ABC) transporter
SY83_RS10335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SY83_RS10340	COG2205	protein histidine kinase activity
SY83_RS10340	COG0784	Response regulator, receiver
SY83_RS10345	COG2197	response regulator
SY83_RS10360	COG0446	pyridine nucleotide-disulphide oxidoreductase
SY83_RS10385	COG4846	Membrane protein involved in cytochrome C biogenesis
SY83_RS10395	COG0662	Cupin 2, conserved barrel domain protein
SY83_RS10395	COG2207	Transcriptional regulator
SY83_RS10400	COG1486	melibiose metabolic process
SY83_RS10420	COG0454	-acetyltransferase
SY83_RS10420	COG0456	acetyltransferase
SY83_RS10435	COG0673	inositol 2-dehydrogenase activity
SY83_RS10440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
SY83_RS10455	COG0590	tRNA wobble adenosine to inosine editing
SY83_RS10465	COG0745	RESPONSE REGULATOR receiver
SY83_RS10470	COG5002	protein histidine kinase activity
SY83_RS10495	COG1263	PTS System
SY83_RS10495	COG2190	(PTS) system
SY83_RS10495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SY83_RS10500	COG2190	(PTS) system
SY83_RS10500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SY83_RS10500	COG1263	PTS System
SY83_RS10505	COG3711	transcriptional antiterminator
SY83_RS10550	COG0745	RESPONSE REGULATOR receiver
SY83_RS10555	COG5002	protein histidine kinase activity
SY83_RS10560	COG0733	neurotransmitter:sodium symporter activity
SY83_RS10565	COG1523	belongs to the glycosyl hydrolase 13 family
SY83_RS10580	COG0765	amino acid transport
SY83_RS10585	COG1126	abc transporter atp-binding protein
SY83_RS10595	COG0012	GTP binding
SY83_RS10600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SY83_RS10605	COG2890	protein-(glutamine-N5) methyltransferase activity
SY83_RS10615	COG0009	L-threonylcarbamoyladenylate synthase
SY83_RS10620	COG1971	Probably functions as a manganese efflux pump
SY83_RS10625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SY83_RS10630	COG0698	ribose 5-phosphate isomerase
SY83_RS10640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SY83_RS10645	COG0300	oxidoreductase activity
SY83_RS10660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SY83_RS10665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SY83_RS10680	COG0356	it plays a direct role in the translocation of protons across the membrane
SY83_RS10685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SY83_RS10695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SY83_RS10700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SY83_RS10705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SY83_RS10710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SY83_RS10715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SY83_RS10730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SY83_RS10735	COG0649	NAD binding
SY83_RS10740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SY83_RS10755	COG0713	ATP synthesis coupled electron transport
SY83_RS10760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SY83_RS10765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SY83_RS10770	COG1007	ATP synthesis coupled electron transport
SY83_RS10775	COG2258	MOSC domain
SY83_RS10785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SY83_RS10790	COG2385	sporulation resulting in formation of a cellular spore
SY83_RS10795	COG0739	heme binding
SY83_RS10800	COG1609	Transcriptional regulator
SY83_RS10810	COG4786	Flagellar basal body rod
SY83_RS10825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SY83_RS10830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SY83_RS10850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SY83_RS10860	COG2373	Large extracellular alpha-helical protein
SY83_RS10865	COG1361	Conserved repeat domain
SY83_RS10900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SY83_RS10925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SY83_RS10930	COG1040	competence protein
SY83_RS10950	COG1256	bacterial-type flagellum assembly
SY83_RS10950	COG4786	Flagellar basal body rod
SY83_RS10955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SY83_RS10965	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SY83_RS10970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SY83_RS10975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SY83_RS10990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SY83_RS11045	COG1278	Cold shock
SY83_RS11055	COG0653	protein targeting
SY83_RS11060	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SY83_RS11065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SY83_RS11070	COG1131	(ABC) transporter
SY83_RS11085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SY83_RS11090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SY83_RS11095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SY83_RS11105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SY83_RS11110	COG0137	argininosuccinate synthase activity
SY83_RS11115	COG0165	Argininosuccinate lyase
SY83_RS11125	COG2720	vancomycin resistance protein
SY83_RS11130	COG2884	Cell division ATP-binding protein ftsE
SY83_RS11135	COG2177	Part of the ABC transporter FtsEX involved in
SY83_RS11140	COG0739	heme binding
SY83_RS11145	COG3409	Peptidoglycan-binding domain 1 protein
SY83_RS11145	COG0793	Belongs to the peptidase S41A family
SY83_RS11150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SY83_RS11155	COG0556	nucleotide-excision repair
SY83_RS11160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SY83_RS11165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SY83_RS11175	COG0039	L-malate dehydrogenase activity
SY83_RS11180	COG0826	peptidase U32
SY83_RS11185	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SY83_RS11190	COG0210	DNA helicase
SY83_RS11195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SY83_RS11225	COG3880	PFAM UvrB UvrC protein
SY83_RS11230	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SY83_RS11235	COG0542	response to heat
SY83_RS11240	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SY83_RS11245	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SY83_RS11250	COG1183	phosphatidylcholine synthase activity
SY83_RS11260	COG4956	integral membrane protein (PIN domain superfamily)
SY83_RS11270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SY83_RS11275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SY83_RS11280	COG1045	serine acetyltransferase
SY83_RS11285	COG0215	cysteine-tRNA ligase activity
SY83_RS11290	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SY83_RS11295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SY83_RS11300	COG3688	RNA-binding protein containing a PIN domain
SY83_RS11315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SY83_RS11320	COG0250	Participates in transcription elongation, termination and antitermination
SY83_RS11330	COG0081	regulation of translation
SY83_RS11335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SY83_RS11340	COG0222	ribosome binding
SY83_RS11345	COG2813	Specifically methylates the guanine in position
SY83_RS11350	COG0085	RNA polymerase activity
SY83_RS11355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SY83_RS11360	COG1358	cellular component organization or biogenesis
SY83_RS11365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SY83_RS11370	COG0049	tRNA binding
SY83_RS11375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SY83_RS11380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SY83_RS11390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SY83_RS11395	COG0088	Forms part of the polypeptide exit tunnel
SY83_RS11400	COG0089	rRNA binding
SY83_RS11405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SY83_RS11410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SY83_RS11415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SY83_RS11420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SY83_RS11425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SY83_RS11430	COG0255	Belongs to the universal ribosomal protein uL29 family
SY83_RS11440	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SY83_RS11445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SY83_RS11450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SY83_RS11455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SY83_RS11460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SY83_RS11465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SY83_RS11470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SY83_RS11475	COG1841	ribosomal large subunit assembly
SY83_RS11480	COG0200	Binds to the 23S rRNA
SY83_RS11485	COG0201	protein transport
SY83_RS11490	COG0563	adenylate kinase activity
SY83_RS11495	COG0024	Methionine aminopeptidase
SY83_RS11500	COG2163	COG2163 Ribosomal protein L14E L6E L27E
SY83_RS11505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SY83_RS11510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SY83_RS11515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SY83_RS11520	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SY83_RS11525	COG0202	RNA polymerase activity
SY83_RS11530	COG0203	ribosomal protein L17
SY83_RS11535	COG0101	tRNA pseudouridine synthase activity
SY83_RS11540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SY83_RS11545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SY83_RS11550	COG0175	sulfate reduction
SY83_RS11555	COG2046	Belongs to the sulfate adenylyltransferase family
SY83_RS11560	COG0860	N-Acetylmuramoyl-L-alanine amidase
SY83_RS11565	COG0489	protein tyrosine kinase activity
SY83_RS11580	COG0726	polysaccharide deacetylase
SY83_RS11660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SY83_RS11665	COG2508	Transcriptional regulator
SY83_RS11670	COG3842	ATPase activity
SY83_RS11680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SY83_RS11690	COG0110	maltose O-acetyltransferase activity
SY83_RS11695	COG0686	Belongs to the AlaDH PNT family
SY83_RS11700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SY83_RS11700	COG2508	Transcriptional regulator
SY83_RS11705	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SY83_RS11710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SY83_RS11715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SY83_RS11720	COG0131	Imidazoleglycerol-phosphate dehydratase
SY83_RS11725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SY83_RS11730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SY83_RS11735	COG0107	imidazoleglycerol-phosphate synthase activity
SY83_RS11740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SY83_RS11740	COG0140	phosphoribosyl-ATP diphosphatase activity
SY83_RS11745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SY83_RS11765	COG0457	Tetratricopeptide repeat
SY83_RS11770	COG0492	ferredoxin-NADP+ reductase activity
SY83_RS11775	COG1940	carbohydrate kinase activity
SY83_RS11780	COG1660	Displays ATPase and GTPase activities
SY83_RS11785	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SY83_RS11790	COG1481	regulation of sporulation
SY83_RS11795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SY83_RS11815	COG1696	Membrane protein involved in D-alanine export
SY83_RS11825	COG0740	serine-type endopeptidase activity
SY83_RS11840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SY83_RS11845	COG0126	phosphoglycerate kinase activity
SY83_RS11850	COG0149	triose-phosphate isomerase activity
SY83_RS11855	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SY83_RS11860	COG0148	phosphopyruvate hydratase activity
SY83_RS11870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SY83_RS11880	COG0557	exoribonuclease II activity
SY83_RS11885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SY83_RS11910	COG1902	pentaerythritol trinitrate reductase activity
SY83_RS11920	COG2207	Transcriptional regulator
SY83_RS11925	COG1129	ABC transporter
SY83_RS11930	COG1879	ABC-type sugar transport system periplasmic component
SY83_RS11935	COG1129	ABC transporter
SY83_RS11940	COG1172	Belongs to the binding-protein-dependent transport system permease family
SY83_RS11965	COG5646	InterPro IPR014922
SY83_RS11980	COG1309	transcriptional regulator
SY83_RS11995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SY83_RS12000	COG2910	NAD(P)H-binding
SY83_RS12005	COG1733	regulation of RNA biosynthetic process
SY83_RS12015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SY83_RS12030	COG2197	response regulator
SY83_RS12040	COG0681	Belongs to the peptidase S26 family
SY83_RS12055	COG2822	iron ion transport
SY83_RS12060	COG2837	iron assimilation
SY83_RS12065	COG0672	)-iron permease
SY83_RS12070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SY83_RS12075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS12080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SY83_RS12085	COG1116	anion transmembrane transporter activity
SY83_RS12115	COG3275	phosphorelay sensor kinase activity
SY83_RS12120	COG4753	response regulator
SY83_RS12120	COG2207	Transcriptional regulator
SY83_RS12130	COG4209	transmembrane transport
SY83_RS12135	COG0395	ABC-type sugar transport system, permease component
SY83_RS12140	COG1653	transport
SY83_RS12150	COG0840	transmembrane signaling receptor activity
SY83_RS12160	COG1511	domain protein
SY83_RS12165	COG2124	cytochrome p450
SY83_RS12170	COG1994	Peptidase M50
SY83_RS12175	COG2310	stress, protein
SY83_RS12180	COG2310	stress, protein
SY83_RS12185	COG2310	stress, protein
SY83_RS12220	COG1278	Cold shock
SY83_RS12230	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
SY83_RS12240	COG0395	ABC-type sugar transport system, permease component
SY83_RS12245	COG1175	transmembrane transport
SY83_RS12255	COG1609	Transcriptional regulator
SY83_RS12275	COG2733	membrane
SY83_RS12280	COG2155	Conserved Protein
SY83_RS12285	COG0508	dehydrogenase complex catalyzes the overall conversion of
SY83_RS12305	COG3341	Caulimovirus viroplasmin
SY83_RS12305	COG0328	RNA-DNA hybrid ribonuclease activity
SY83_RS12310	COG2267	carboxylic ester hydrolase activity
SY83_RS12315	COG1368	sulfuric ester hydrolase activity
SY83_RS12340	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SY83_RS12345	COG2308	Evidence 4 Homologs of previously reported genes of
SY83_RS12365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SY83_RS12370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SY83_RS12380	COG2205	protein histidine kinase activity
SY83_RS12390	COG2182	Extracellular solute-binding protein
SY83_RS12395	COG1175	transmembrane transport
SY83_RS12400	COG0395	ABC-type sugar transport system, permease component
SY83_RS12405	COG2972	Histidine kinase
SY83_RS12410	COG1472	Belongs to the glycosyl hydrolase 3 family
SY83_RS12430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SY83_RS12435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SY83_RS12440	COG2175	clavaminate synthase activity
SY83_RS12450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SY83_RS12470	COG1120	ATPase activity
SY83_RS12485	COG0800	Aldolase
SY83_RS12495	COG0833	amino acid
SY83_RS12500	COG1595	DNA-templated transcription, initiation
SY83_RS12515	COG3584	3D domain protein
SY83_RS12520	COG0515	serine threonine protein kinase
SY83_RS12545	COG1388	LysM domain
SY83_RS12545	COG3858	chitin binding
SY83_RS12550	COG3546	catalase activity
SY83_RS12565	COG0739	heme binding
SY83_RS12585	COG0778	Nitroreductase
SY83_RS12595	COG0534	Mate efflux family protein
SY83_RS12620	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SY83_RS12625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SY83_RS12630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SY83_RS12650	COG1714	RDD family
SY83_RS12665	COG0398	Pfam SNARE associated Golgi protein
SY83_RS12670	COG2814	Major facilitator Superfamily
SY83_RS12675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SY83_RS12680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SY83_RS12685	COG2011	ABC-type metal ion transport system permease component
SY83_RS12705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SY83_RS12715	COG0024	Methionine aminopeptidase
SY83_RS12720	COG2746	aminoglycoside 3-N-acetyltransferase activity
SY83_RS12730	COG1309	transcriptional regulator
SY83_RS12745	COG0070	glutamate synthase
SY83_RS12745	COG0069	glutamate synthase activity
SY83_RS12745	COG0067	glutamate synthase
SY83_RS12750	COG2972	Histidine kinase
SY83_RS12755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SY83_RS12755	COG2207	Transcriptional regulator
SY83_RS12765	COG4209	transmembrane transport
SY83_RS12770	COG0395	ABC-type sugar transport system, permease component
SY83_RS12775	COG5183	chlorophyll binding
SY83_RS12775	COG2133	pyrroloquinoline quinone binding
SY83_RS12790	COG0463	Glycosyl transferase, family 2
SY83_RS12810	COG0672	)-iron permease
SY83_RS12815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SY83_RS12825	COG0326	Molecular chaperone. Has ATPase activity
SY83_RS12840	COG1131	(ABC) transporter
SY83_RS12845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SY83_RS12850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SY83_RS12870	COG0739	heme binding
SY83_RS12890	COG0697	spore germination
SY83_RS12900	COG3285	dna ligase
SY83_RS12900	COG1793	dna ligase
SY83_RS12915	COG0802	atpase or kinase
SY83_RS12920	COG1214	PFAM Peptidase M22, glycoprotease
SY83_RS12925	COG0456	acetyltransferase
SY83_RS13000	COG0488	(ABC) transporter
SY83_RS13010	COG0315	cyclic pyranopterin monophosphate synthase activity
SY83_RS13015	COG0521	Mo-molybdopterin cofactor biosynthetic process
SY83_RS13025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SY83_RS13030	COG0805	protein transport
SY83_RS13035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SY83_RS13040	COG0459	protein refolding
SY83_RS13110	COG2076	Multidrug Resistance protein
SY83_RS13115	COG0438	transferase activity, transferring glycosyl groups
SY83_RS13125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SY83_RS13130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SY83_RS13145	COG1091	dTDP-4-dehydrorhamnose reductase activity
SY83_RS13160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SY83_RS13165	COG4464	protein tyrosine phosphatase activity
SY83_RS13175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SY83_RS13180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SY83_RS13185	COG0864	Transcriptional regulator
SY83_RS13190	COG2337	Toxic component of a toxin-antitoxin (TA) module
SY83_RS13195	COG2183	response to ionizing radiation
SY83_RS13210	COG3091	SprT-like family
SY83_RS13255	COG1874	Beta-galactosidase
SY83_RS13260	COG2972	Histidine kinase
SY83_RS13265	COG2169	Transcriptional regulator
SY83_RS13270	COG4209	transmembrane transport
SY83_RS13275	COG0395	ABC-type sugar transport system, permease component
SY83_RS13300	COG4753	response regulator
SY83_RS13300	COG2207	Transcriptional regulator
SY83_RS13305	COG3119	arylsulfatase activity
SY83_RS13310	COG2207	Transcriptional regulator
SY83_RS13310	COG1609	Transcriptional regulator
SY83_RS13315	COG4209	transmembrane transport
SY83_RS13320	COG0395	ABC-type sugar transport system, permease component
SY83_RS13325	COG1653	transport
SY83_RS13330	COG3119	arylsulfatase activity
SY83_RS13355	COG4948	Mandelate Racemase Muconate Lactonizing
SY83_RS13365	COG4209	transmembrane transport
SY83_RS13370	COG0395	ABC-type sugar transport system, permease component
SY83_RS13380	COG2207	Transcriptional regulator
SY83_RS13380	COG4753	response regulator
SY83_RS13410	COG2186	Transcriptional regulator
SY83_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS13430	COG1175	transmembrane transport
SY83_RS13435	COG0395	ABC-type sugar transport system, permease component
SY83_RS13450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SY83_RS13465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SY83_RS13480	COG3250	beta-galactosidase activity
SY83_RS13485	COG3940	Belongs to the glycosyl hydrolase 43 family
SY83_RS13495	COG4209	transmembrane transport
SY83_RS13500	COG0395	ABC-type sugar transport system, permease component
SY83_RS13505	COG2207	Transcriptional regulator
SY83_RS13505	COG2207	Transcriptional regulator
SY83_RS13505	COG4753	response regulator
SY83_RS13505	COG4753	response regulator
SY83_RS13510	COG3275	phosphorelay sensor kinase activity
SY83_RS13515	COG1653	transport
SY83_RS13525	COG2207	Transcriptional regulator
SY83_RS13525	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS13555	COG1070	Carbohydrate kinase
SY83_RS13575	COG2226	methyltransferase
SY83_RS13580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SY83_RS13585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SY83_RS13590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS13595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SY83_RS13600	COG5401	PFAM Sporulation and spore germination
SY83_RS13605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SY83_RS13610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SY83_RS13615	COG0367	asparagine synthase
SY83_RS13645	COG0544	peptidyl-prolyl cis-trans isomerase activity
SY83_RS13650	COG0740	serine-type endopeptidase activity
SY83_RS13655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SY83_RS13660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SY83_RS13670	COG1619	proteins homologs of microcin C7 resistance protein MccF
SY83_RS13685	COG1067	ATP-dependent peptidase activity
SY83_RS13685	COG0470	DNA polymerase III
SY83_RS13695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SY83_RS13705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SY83_RS13720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SY83_RS13725	COG1648	precorrin-2 dehydrogenase activity
SY83_RS13725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SY83_RS13740	COG0113	porphobilinogen synthase activity
SY83_RS13745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SY83_RS13750	COG0564	pseudouridine synthase activity
SY83_RS13755	COG1388	LysM domain
SY83_RS13760	COG0525	valine-tRNA ligase activity
SY83_RS13765	COG0285	dihydrofolate synthase activity
SY83_RS13770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SY83_RS13795	COG0424	maF-like protein
SY83_RS13800	COG2003	Belongs to the UPF0758 family
SY83_RS13805	COG1077	Cell shape determining protein MreB Mrl
SY83_RS13825	COG2894	cell division
SY83_RS13830	COG0772	Belongs to the SEDS family
SY83_RS13850	COG1994	Peptidase M50
SY83_RS13855	COG1530	ribonuclease E activity
SY83_RS13860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SY83_RS13865	COG2868	ribosomal protein
SY83_RS13885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SY83_RS13890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SY83_RS13895	COG4492	Belongs to the UPF0735 family
SY83_RS13900	COG0460	homoserine dehydrogenase
SY83_RS13910	COG0077	Prephenate dehydratase
SY83_RS13920	COG1388	LysM domain
SY83_RS13920	COG0791	NLP P60 protein
SY83_RS13930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SY83_RS13935	COG0632	four-way junction helicase activity
SY83_RS13940	COG2255	four-way junction helicase activity
SY83_RS13945	COG2385	sporulation resulting in formation of a cellular spore
SY83_RS13950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SY83_RS13960	COG1862	Preprotein translocase
SY83_RS13965	COG0671	phosphoesterase, PA-phosphatase related
SY83_RS13975	COG2323	membrane
SY83_RS13980	COG2244	polysaccharide biosynthetic process
SY83_RS14000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SY83_RS14000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SY83_RS14005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SY83_RS14015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SY83_RS14020	COG1490	D-aminoacyl-tRNA deacylase activity
SY83_RS14025	COG0124	histidyl-tRNA synthetase
SY83_RS14030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SY83_RS14035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SY83_RS14045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SY83_RS14055	COG0482	sulfurtransferase activity
SY83_RS14060	COG1959	2 iron, 2 sulfur cluster binding
SY83_RS14065	COG1104	cysteine desulfurase activity
SY83_RS14080	COG0628	permease
SY83_RS14085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SY83_RS14090	COG4472	Bacterial protein of unknown function (DUF965)
SY83_RS14095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SY83_RS14100	COG3906	Belongs to the UPF0473 family
SY83_RS14110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SY83_RS14115	COG0826	peptidase U32
SY83_RS14120	COG0826	peptidase U32
SY83_RS14125	COG0840	transmembrane signaling receptor activity
SY83_RS14130	COG0768	penicillin binding
SY83_RS14135	COG0628	permease
SY83_RS14160	COG1309	transcriptional regulator
SY83_RS14175	COG1819	glycosyl
SY83_RS14195	COG1609	Transcriptional regulator
SY83_RS14195	COG2207	Transcriptional regulator
SY83_RS14210	COG1609	Transcriptional regulator
SY83_RS14225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SY83_RS14235	COG1175	transmembrane transport
SY83_RS14240	COG3833	ABC-type maltose transport systems, permease component
SY83_RS14250	COG0383	alpha-mannosidase activity
SY83_RS14265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SY83_RS14275	COG2182	Extracellular solute-binding protein
SY83_RS14280	COG1175	transmembrane transport
SY83_RS14285	COG3833	ABC-type maltose transport systems, permease component
SY83_RS14290	COG1609	Transcriptional regulator
SY83_RS14310	COG1562	ergosterol biosynthetic process
SY83_RS14325	COG1215	transferase activity, transferring glycosyl groups
SY83_RS14330	COG1233	COG1233 Phytoene dehydrogenase and related
SY83_RS14335	COG1304	FMN binding
SY83_RS14340	COG2323	membrane
SY83_RS14350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SY83_RS14360	COG0714	Associated with various cellular activities
SY83_RS14370	COG1305	Transglutaminase-like
SY83_RS14380	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SY83_RS14385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SY83_RS14390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SY83_RS14395	COG1534	Rna-binding protein
SY83_RS14400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SY83_RS14405	COG1713	HD superfamily hydrolase involved in NAD metabolism
SY83_RS14410	COG0799	negative regulation of ribosome biogenesis
SY83_RS14415	COG2996	Protein conserved in bacteria
SY83_RS14420	COG2226	methyltransferase
SY83_RS14425	COG0495	leucyl-tRNA aminoacylation
SY83_RS14430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SY83_RS14435	COG1555	photosystem II stabilization
SY83_RS14435	COG1596	polysaccharide export
SY83_RS14475	COG1595	DNA-templated transcription, initiation
SY83_RS14485	COG1466	dna polymerase III delta subunit
SY83_RS14490	COG0268	Binds directly to 16S ribosomal RNA
SY83_RS14500	COG0860	N-Acetylmuramoyl-L-alanine amidase
SY83_RS14515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SY83_RS14550	COG1420	regulation of RNA biosynthetic process
SY83_RS14555	COG0459	protein refolding
SY83_RS14575	COG1316	TRANSCRIPTIONal
SY83_RS14580	COG0561	phosphatase activity
SY83_RS14585	COG1349	DNA-binding transcription factor activity
SY83_RS14605	COG1994	Peptidase M50
SY83_RS14610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SY83_RS14615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SY83_RS14625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SY83_RS14630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SY83_RS14645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SY83_RS14650	COG1132	(ABC) transporter
SY83_RS14655	COG1132	(ABC) transporter
SY83_RS14660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SY83_RS14665	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SY83_RS14670	COG1074	ATP-dependent DNA helicase activity
SY83_RS14675	COG0420	3'-5' exonuclease activity
SY83_RS14680	COG0419	ATPase involved in DNA repair
SY83_RS14695	COG0537	adenosine 5'-monophosphoramidase activity
SY83_RS14700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SY83_RS14705	COG1610	YqeY-like protein
SY83_RS14710	COG1030	water channel activity
SY83_RS14715	COG4864	UPF0365 protein
SY83_RS14735	COG1702	phosphate starvation-inducible protein PhoH
SY83_RS14740	COG1480	7TM receptor with intracellular HD hydrolase
SY83_RS14745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SY83_RS14750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SY83_RS14760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SY83_RS14765	COG1381	Involved in DNA repair and RecF pathway recombination
SY83_RS14770	COG0752	glycyl-tRNA synthetase alpha subunit
SY83_RS14775	COG0751	glycine-tRNA ligase activity
SY83_RS14780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SY83_RS14790	COG0358	DNA primase activity
SY83_RS14810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SY83_RS14840	COG0741	lytic transglycosylase activity
SY83_RS14845	COG1104	cysteine desulfurase activity
SY83_RS14850	COG0301	tRNA thio-modification
SY83_RS14855	COG0861	Integral membrane protein TerC family
SY83_RS14860	COG0861	Integral membrane protein TerC family
SY83_RS14870	COG1217	gtp-binding protein TYPA
SY83_RS14885	COG1316	TRANSCRIPTIONal
SY83_RS14895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SY83_RS14930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SY83_RS14940	COG4166	transmembrane transport
SY83_RS14945	COG0601	transmembrane transport
SY83_RS14950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SY83_RS14955	COG0444	Belongs to the ABC transporter superfamily
SY83_RS14960	COG4608	Belongs to the ABC transporter superfamily
SY83_RS14965	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SY83_RS14970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SY83_RS14980	COG2001	Belongs to the MraZ family
SY83_RS14985	COG0275	rRNA processing
SY83_RS14995	COG0768	penicillin binding
SY83_RS15000	COG0768	penicillin binding
SY83_RS15010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SY83_RS15020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SY83_RS15025	COG0772	Belongs to the SEDS family
SY83_RS15030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SY83_RS15035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SY83_RS15040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SY83_RS15045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SY83_RS15050	COG0849	cell division
SY83_RS15055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SY83_RS15065	COG1191	sigma factor activity
SY83_RS15070	COG1191	sigma factor activity
SY83_RS15075	COG1846	Transcriptional regulator
SY83_RS15085	COG1873	PFAM PRC-barrel domain
SY83_RS15090	COG1496	oxidoreductase activity
SY83_RS15095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SY83_RS15100	COG1799	cell septum assembly
SY83_RS15110	COG2302	S4 RNA-binding domain
SY83_RS15115	COG3599	regulation of cell shape
SY83_RS15120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SY83_RS15130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SY83_RS15135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SY83_RS15140	COG0564	pseudouridine synthase activity
SY83_RS15145	COG0436	Aminotransferase
SY83_RS15150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SY83_RS15155	COG0540	Belongs to the ATCase OTCase family
SY83_RS15160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SY83_RS15165	COG0505	Belongs to the CarA family
SY83_RS15170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SY83_RS15185	COG1595	DNA-templated transcription, initiation
SY83_RS15190	COG1136	(ABC) transporter
SY83_RS15195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SY83_RS15205	COG1136	(ABC) transporter
SY83_RS15225	COG2205	protein histidine kinase activity
SY83_RS15225	COG0784	Response regulator, receiver
SY83_RS15225	COG2198	Histidine kinase
SY83_RS15230	COG0564	pseudouridine synthase activity
SY83_RS15235	COG2076	Multidrug Resistance protein
SY83_RS15260	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SY83_RS15265	COG2153	protein acetylation
SY83_RS15275	COG1234	tRNA 3'-trailer cleavage
SY83_RS15290	COG3906	Belongs to the UPF0473 family
SY83_RS15300	COG1982	Orn Lys Arg decarboxylase major
SY83_RS15310	COG1744	ABC transporter substrate-binding protein PnrA-like
SY83_RS15315	COG3845	ABC transporter
SY83_RS15320	COG4603	Belongs to the binding-protein-dependent transport system permease family
SY83_RS15325	COG1079	Belongs to the binding-protein-dependent transport system permease family
SY83_RS15330	COG1309	transcriptional regulator
SY83_RS15340	COG1131	(ABC) transporter
SY83_RS15345	COG4493	Belongs to the UPF0637 family
SY83_RS15355	COG1070	Carbohydrate kinase
SY83_RS15360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SY83_RS15370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SY83_RS15375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SY83_RS15380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SY83_RS15385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SY83_RS15390	COG1832	CoA-binding protein
SY83_RS15405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SY83_RS15425	COG1609	Transcriptional regulator
SY83_RS15430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SY83_RS15435	COG0123	including yeast histone deacetylase and acetoin utilization protein
SY83_RS15440	COG0454	-acetyltransferase
SY83_RS15445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SY83_RS15450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SY83_RS15455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SY83_RS15460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SY83_RS15465	COG2199	diguanylate cyclase activity
SY83_RS15465	COG2203	Gaf domain
SY83_RS15485	COG4838	Belongs to the UPF0358 family
SY83_RS15490	COG0387	Pfam Sodium calcium exchanger
SY83_RS15495	COG1302	Protein conserved in bacteria
SY83_RS15500	COG0772	Belongs to the SEDS family
SY83_RS15510	COG1473	amidohydrolase
SY83_RS15515	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SY83_RS15525	COG1061	Type III restriction enzyme res subunit
SY83_RS15560	COG0613	PHP domain protein
SY83_RS15565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SY83_RS15585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SY83_RS15590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SY83_RS15595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SY83_RS15595	COG0646	methionine synthase
SY83_RS15600	COG1561	YicC-like family, N-terminal region
SY83_RS15605	COG2052	Domain of unknown function (DUF370)
SY83_RS15610	COG0194	GDP metabolic process
SY83_RS15615	COG1758	RNA polymerase activity
SY83_RS15620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SY83_RS15625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SY83_RS15630	COG0242	peptide deformylase activity
SY83_RS15635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SY83_RS15640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SY83_RS15640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SY83_RS15645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SY83_RS15650	COG0631	protein serine/threonine phosphatase activity
SY83_RS15655	COG0515	serine threonine protein kinase
SY83_RS15655	COG2815	serine threonine protein kinase
SY83_RS15665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SY83_RS15675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SY83_RS15680	COG1302	Protein conserved in bacteria
SY83_RS15685	COG1461	Dihydroxyacetone kinase
SY83_RS15690	COG1307	EDD domain protein, DegV family
SY83_RS15695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SY83_RS15725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SY83_RS15735	COG0583	DNA-binding transcription factor activity
SY83_RS15760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SY83_RS15765	COG0742	ribosomal rna small subunit methyltransferase
SY83_RS15770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SY83_RS15775	COG3314	Sporulation integral membrane protein YlbJ
SY83_RS15780	COG3480	Lon protease (S16) C-terminal proteolytic domain
SY83_RS15785	COG1323	Belongs to the UPF0348 family
SY83_RS15795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SY83_RS15800	COG1349	DNA-binding transcription factor activity
SY83_RS15805	COG0416	fatty acid biosynthetic process
SY83_RS15815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SY83_RS15820	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS15825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SY83_RS15830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SY83_RS15835	COG0571	ribonuclease III activity
SY83_RS15840	COG1196	nuclear chromosome segregation
SY83_RS15845	COG0552	protein localization to endoplasmic reticulum
SY83_RS15850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SY83_RS15855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SY83_RS15860	COG0228	four-way junction DNA binding
SY83_RS15870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SY83_RS15875	COG0336	Belongs to the RNA methyltransferase TrmD family
SY83_RS15880	COG0335	large ribosomal subunit rRNA binding
SY83_RS15895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SY83_RS15910	COG0792	nuclease activity
SY83_RS15915	COG0606	chelatase, subunit chli
SY83_RS15930	COG0045	succinate-CoA ligase (ADP-forming) activity
SY83_RS15935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SY83_RS15940	COG0758	DNA mediated transformation
SY83_RS15940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SY83_RS15945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SY83_RS15950	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SY83_RS15955	COG4974	Belongs to the 'phage' integrase family
SY83_RS15960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SY83_RS15965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SY83_RS15970	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SY83_RS15975	COG1815	bacterial-type flagellum-dependent cell motility
SY83_RS15980	COG1558	bacterial-type flagellum-dependent cell motility
SY83_RS15985	COG1677	Flagellar hook-basal body complex protein FliE
SY83_RS15990	COG1766	The M ring may be actively involved in energy transduction
SY83_RS15995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SY83_RS16005	COG1157	protein secretion by the type III secretion system
SY83_RS16025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SY83_RS16035	COG4786	Flagellar basal body rod
SY83_RS16050	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SY83_RS16055	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SY83_RS16055	COG1776	CheC inhibitor of MCP methylation
SY83_RS16060	COG2201	protein-glutamate methylesterase activity
SY83_RS16070	COG1338	Plays a role in the flagellum-specific transport system
SY83_RS16075	COG1987	bacterial-type flagellum assembly
SY83_RS16080	COG1684	flagellar biosynthetic protein fliR
SY83_RS16085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SY83_RS16090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SY83_RS16095	COG1419	protein localization to endoplasmic reticulum
SY83_RS16100	COG0455	bacterial-type flagellum organization
SY83_RS16105	COG2201	protein-glutamate methylesterase activity
SY83_RS16110	COG2198	Histidine kinase
SY83_RS16110	COG0643	Histidine kinase
SY83_RS16115	COG0835	chemotaxis
SY83_RS16120	COG1776	CheC inhibitor of MCP methylation
SY83_RS16125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SY83_RS16135	COG1191	sigma factor activity
SY83_RS16160	COG0052	Belongs to the universal ribosomal protein uS2 family
SY83_RS16165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SY83_RS16170	COG0528	UMP kinase activity
SY83_RS16175	COG0233	cytoplasmic translational termination
SY83_RS16185	COG4589	Belongs to the CDS family
SY83_RS16190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SY83_RS16195	COG0750	zinc metalloprotease
SY83_RS16200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SY83_RS16205	COG2176	DNA-directed DNA polymerase activity
SY83_RS16210	COG0779	Required for maturation of 30S ribosomal subunits
SY83_RS16215	COG0195	Participates in both transcription termination and antitermination
SY83_RS16225	COG1358	cellular component organization or biogenesis
SY83_RS16230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SY83_RS16235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SY83_RS16240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SY83_RS16245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SY83_RS16250	COG0196	riboflavin kinase activity
SY83_RS16255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SY83_RS16260	COG1185	polyribonucleotide nucleotidyltransferase activity
SY83_RS16265	COG0726	polysaccharide deacetylase
SY83_RS16270	COG0612	Peptidase, M16
SY83_RS16275	COG0756	dUTP diphosphatase activity
SY83_RS16280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SY83_RS16285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SY83_RS16290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SY83_RS16295	COG0527	aspartate kinase activity
SY83_RS16300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SY83_RS16305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SY83_RS16310	COG0740	serine-type endopeptidase activity
SY83_RS16320	COG1674	ftsk spoiiie
SY83_RS16330	COG0612	Peptidase, M16
SY83_RS16335	COG0612	Peptidase, M16
SY83_RS16340	COG0300	oxidoreductase activity
SY83_RS16355	COG1426	Protein conserved in bacteria
SY83_RS16365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SY83_RS16370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SY83_RS16375	COG1546	Belongs to the CinA family
SY83_RS16375	COG1058	Belongs to the CinA family
SY83_RS16380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SY83_RS16385	COG2137	regulation of response to DNA damage stimulus
SY83_RS16390	COG1418	mRNA catabolic process
SY83_RS16395	COG1692	metallophosphoesterase
SY83_RS16400	COG2359	stage V sporulation protein S
SY83_RS16415	COG1013	pyruvate-flavodoxin oxidoreductase activity
SY83_RS16420	COG4869	propanediol catabolic process
SY83_RS16425	COG2814	Major facilitator Superfamily
SY83_RS16430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SY83_RS16435	COG4550	Control of competence regulator ComK, YlbF/YmcA
SY83_RS16450	COG0601	transmembrane transport
SY83_RS16455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SY83_RS16460	COG0444	Belongs to the ABC transporter superfamily
SY83_RS16465	COG4608	Belongs to the ABC transporter superfamily
SY83_RS16470	COG0745	RESPONSE REGULATOR receiver
SY83_RS16475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SY83_RS16485	COG0656	L-ascorbic acid biosynthetic process
SY83_RS16490	COG0492	ferredoxin-NADP+ reductase activity
SY83_RS16515	COG4895	conserved protein (DUF2196)
SY83_RS16525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SY83_RS16530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SY83_RS16545	COG1979	alcohol dehydrogenase
SY83_RS16550	COG1643	Atp-dependent helicase
SY83_RS16565	COG0463	Glycosyl transferase, family 2
SY83_RS16595	COG4989	oxidoreductase activity
SY83_RS16600	COG1418	mRNA catabolic process
SY83_RS16630	COG0463	Glycosyl transferase, family 2
SY83_RS16630	COG0457	Tetratricopeptide repeat
SY83_RS16640	COG0405	Gamma-glutamyltransferase
SY83_RS16645	COG2059	Chromate
SY83_RS16650	COG2508	Transcriptional regulator
SY83_RS16655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SY83_RS16670	COG3845	ABC transporter
SY83_RS16675	COG4603	Belongs to the binding-protein-dependent transport system permease family
SY83_RS16690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SY83_RS16695	COG2080	2 iron, 2 sulfur cluster binding
SY83_RS16705	COG3648	Uricase
SY83_RS16705	COG3195	allantoin biosynthetic process
SY83_RS16710	COG2351	hydroxyisourate hydrolase activity
SY83_RS16715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SY83_RS16720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SY83_RS16725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SY83_RS16750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SY83_RS16755	COG1116	anion transmembrane transporter activity
SY83_RS16760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SY83_RS16765	COG1082	Xylose isomerase domain protein TIM barrel
SY83_RS16770	COG0322	excinuclease ABC activity
SY83_RS16785	COG1801	Protein of unknown function DUF72
SY83_RS16795	COG4209	transmembrane transport
SY83_RS16800	COG0395	ABC-type sugar transport system, permease component
SY83_RS16805	COG1653	transport
SY83_RS16815	COG0778	Nitroreductase
SY83_RS16825	COG1876	peptidase activity
SY83_RS16830	COG1199	ATP-dependent helicase activity
SY83_RS16845	COG1131	(ABC) transporter
SY83_RS16860	COG2133	pyrroloquinoline quinone binding
SY83_RS16865	COG2066	Belongs to the glutaminase family
SY83_RS16880	COG1278	Cold shock
SY83_RS16895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SY83_RS16900	COG0330	HflC and HflK could
SY83_RS16905	COG0330	HflC and HflK could
SY83_RS16910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SY83_RS16915	COG5522	Integral membrane protein (intg_mem_TP0381)
SY83_RS16920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SY83_RS16925	COG1122	ATPase activity
SY83_RS16930	COG1122	ATPase activity
SY83_RS16935	COG1268	BioY protein
SY83_RS16950	COG1131	(ABC) transporter
SY83_RS16965	COG2323	membrane
SY83_RS16970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SY83_RS16995	COG0583	DNA-binding transcription factor activity
SY83_RS17000	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SY83_RS17005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SY83_RS17010	COG2309	aminopeptidase activity
SY83_RS17030	COG4974	Belongs to the 'phage' integrase family
SY83_RS17040	COG0740	serine-type endopeptidase activity
SY83_RS17050	COG2261	transglycosylase associated protein
SY83_RS17055	COG2207	Transcriptional regulator
SY83_RS17070	COG1175	transmembrane transport
SY83_RS17080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SY83_RS17085	COG2169	Transcriptional regulator
SY83_RS17090	COG1757	Na H antiporter
SY83_RS17105	COG1802	Transcriptional regulator
SY83_RS17110	COG4948	Mandelate Racemase Muconate Lactonizing
SY83_RS17125	COG0454	-acetyltransferase
SY83_RS17130	COG0667	Aldo Keto reductase
SY83_RS17140	COG0697	spore germination
SY83_RS17155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SY83_RS17160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SY83_RS17175	COG0579	oxidoreductase
SY83_RS17180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SY83_RS17190	COG0778	Nitroreductase
SY83_RS17195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS17200	COG1686	Belongs to the peptidase S11 family
SY83_RS17205	COG3119	arylsulfatase activity
SY83_RS17215	COG4221	oxidoreductase activity
SY83_RS17270	COG1733	regulation of RNA biosynthetic process
SY83_RS17275	COG0725	ABC transporter, periplasmic molybdate-binding protein
SY83_RS17280	COG4149	molybdate abc transporter
SY83_RS17330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SY83_RS17335	COG0640	Transcriptional regulator
SY83_RS17340	COG1012	belongs to the aldehyde dehydrogenase family
SY83_RS17350	COG0318	PFAM AMP-dependent synthetase and ligase
SY83_RS17355	COG1960	acyl-CoA dehydrogenase activity
SY83_RS17360	COG0183	Belongs to the thiolase family
SY83_RS17365	COG1024	Enoyl-CoA hydratase
SY83_RS17365	COG1250	3-hydroxyacyl-CoA dehydrogenase
SY83_RS17370	COG2181	nitrate reductase activity
SY83_RS17370	COG0247	lactate metabolic process
SY83_RS17375	COG1309	transcriptional regulator
SY83_RS17380	COG2086	electron transfer activity
SY83_RS17385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SY83_RS17390	COG2329	Antibiotic biosynthesis monooxygenase
SY83_RS17400	COG5002	protein histidine kinase activity
SY83_RS17400	COG2198	Histidine kinase
SY83_RS17400	COG0784	Response regulator, receiver
SY83_RS17430	COG2340	Cysteine-rich secretory protein family
SY83_RS17440	COG2755	lipolytic protein G-D-S-L family
SY83_RS17445	COG0477	Major facilitator Superfamily
SY83_RS17450	COG1408	metallophosphoesterase
SY83_RS17480	COG0551	DNA topoisomerase type I activity
SY83_RS17480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SY83_RS17485	COG0095	Lipoate-protein ligase
SY83_RS17490	COG0673	inositol 2-dehydrogenase activity
SY83_RS17495	COG0546	phosphoglycolate phosphatase activity
SY83_RS17500	COG1307	EDD domain protein, DegV family
SY83_RS17510	COG4533	DNA binding
SY83_RS17515	COG0493	'glutamate synthase
SY83_RS17530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SY83_RS17535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SY83_RS17540	COG4548	von Willebrand factor, type A
SY83_RS17545	COG0714	Associated with various cellular activities
SY83_RS17570	COG2382	esterase
SY83_RS17575	COG0586	Pfam SNARE associated Golgi protein
SY83_RS17590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SY83_RS17595	COG2860	membrane
SY83_RS17600	COG0363	glucosamine-6-phosphate deaminase activity
SY83_RS17605	COG1940	carbohydrate kinase activity
SY83_RS17610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SY83_RS17625	COG0105	UTP biosynthetic process
SY83_RS17655	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
SY83_RS17670	COG0346	lactoylglutathione lyase activity
SY83_RS17690	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SY83_RS17700	COG0456	acetyltransferase
SY83_RS17705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SY83_RS17705	COG3153	acetyltransferase
SY83_RS17710	COG0791	NLP P60 protein
SY83_RS17715	COG5002	protein histidine kinase activity
SY83_RS17715	COG3850	Histidine kinase
SY83_RS17720	COG0745	RESPONSE REGULATOR receiver
SY83_RS17725	COG5583	Uncharacterized small protein (DUF2292)
SY83_RS17740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SY83_RS17745	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SY83_RS17750	COG4208	sulfate ABC transporter
SY83_RS17755	COG1357	PFAM Pentapeptide repeats (8 copies)
SY83_RS17760	COG1172	Belongs to the binding-protein-dependent transport system permease family
SY83_RS17765	COG1129	ABC transporter
SY83_RS17785	COG0488	(ABC) transporter
SY83_RS17810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SY83_RS17870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
SY83_RS17875	COG1119	ATPase activity
SY83_RS17880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SY83_RS17885	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SY83_RS17890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SY83_RS17895	COG0647	UMP catabolic process
SY83_RS17900	COG0673	inositol 2-dehydrogenase activity
SY83_RS17905	COG3359	exonuclease
SY83_RS17910	COG1205	dead DEAH box helicase
SY83_RS17910	COG1111	helicase
SY83_RS17925	COG1988	membrane-bound metal-dependent
SY83_RS17930	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SY83_RS17935	COG1234	tRNA 3'-trailer cleavage
SY83_RS17940	COG0646	methionine synthase
SY83_RS17940	COG1410	methionine synthase
SY83_RS17945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SY83_RS17950	COG1011	Hydrolase
SY83_RS17970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SY83_RS17975	COG0174	glutamine synthetase
SY83_RS17980	COG0789	Transcriptional regulator
SY83_RS17985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SY83_RS17990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SY83_RS17995	COG0464	growth
SY83_RS18000	COG2198	Histidine kinase
SY83_RS18000	COG5002	protein histidine kinase activity
SY83_RS18000	COG0784	Response regulator, receiver
SY83_RS18005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SY83_RS18025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SY83_RS18030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SY83_RS18035	COG1923	regulation of RNA biosynthetic process
SY83_RS18040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SY83_RS18045	COG2136	Putative SAM-dependent methyltransferase
SY83_RS18045	COG2521	methyltransferase
SY83_RS18050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SY83_RS18060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SY83_RS18085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SY83_RS18090	COG4918	Iron-sulphur cluster biosynthesis
SY83_RS18095	COG0288	reversible hydration of carbon dioxide
SY83_RS18100	COG1547	Domain of unknown function (DUF309)
SY83_RS18120	COG0477	Major facilitator Superfamily
SY83_RS18125	COG1846	Transcriptional regulator
SY83_RS18135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
SY83_RS18140	COG2323	membrane
SY83_RS18165	COG0116	Belongs to the methyltransferase superfamily
SY83_RS18165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SY83_RS18180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SY83_RS18185	COG0187	DNA topoisomerase II activity
SY83_RS18195	COG1131	(ABC) transporter
SY83_RS18205	COG1132	(ABC) transporter
SY83_RS18210	COG1132	(ABC) transporter
SY83_RS18215	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SY83_RS18225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SY83_RS18240	COG0066	3-isopropylmalate dehydratase activity
SY83_RS18245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SY83_RS18250	COG0583	DNA-binding transcription factor activity
SY83_RS18255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SY83_RS18260	COG0436	Aminotransferase
SY83_RS18265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SY83_RS18270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SY83_RS18280	COG1850	ribulose-bisphosphate carboxylase activity
SY83_RS18285	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
SY83_RS18290	COG0235	Class ii aldolase
SY83_RS18305	COG3935	DnaD domain protein
SY83_RS18310	COG0017	Asparaginyl-tRNA synthetase
SY83_RS18315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SY83_RS18320	COG1250	3-hydroxyacyl-CoA dehydrogenase
SY83_RS18325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SY83_RS18340	COG0402	S-adenosylhomocysteine deaminase activity
SY83_RS18350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SY83_RS18355	COG1199	ATP-dependent helicase activity
SY83_RS18355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SY83_RS18365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SY83_RS18370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SY83_RS18385	COG0617	tRNA 3'-terminal CCA addition
SY83_RS18390	COG0438	transferase activity, transferring glycosyl groups
SY83_RS18395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SY83_RS18400	COG1803	Methylglyoxal synthase
SY83_RS18405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SY83_RS18415	COG1694	Mazg nucleotide pyrophosphohydrolase
SY83_RS18420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SY83_RS18430	COG4347	Protein of unknown function (DUF1405)
SY83_RS18435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SY83_RS18435	COG2010	Cytochrome c
SY83_RS18445	COG0723	plastoquinol--plastocyanin reductase activity
SY83_RS18465	COG0406	alpha-ribazole phosphatase activity
SY83_RS18475	COG1595	DNA-templated transcription, initiation
SY83_RS18480	COG0287	Prephenate dehydrogenase
SY83_RS18485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SY83_RS18500	COG0135	phosphoribosylanthranilate isomerase activity
SY83_RS18505	COG0134	indole-3-glycerol-phosphate synthase activity
SY83_RS18510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SY83_RS18520	COG4401	Chorismate mutase type I
SY83_RS18525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SY83_RS18530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SY83_RS18535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SY83_RS18540	COG0105	UTP biosynthetic process
SY83_RS18545	COG0142	geranyltranstransferase activity
SY83_RS18550	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SY83_RS18555	COG0163	prenyltransferase activity
SY83_RS18560	COG0109	protoheme IX farnesyltransferase activity
SY83_RS18565	COG2226	methyltransferase
SY83_RS18585	COG2814	Major facilitator Superfamily
SY83_RS18595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SY83_RS18630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SY83_RS18635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SY83_RS18640	COG1160	GTP binding
SY83_RS18655	COG0539	negative regulation of cytoplasmic translation
SY83_RS18665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SY83_RS18680	COG2959	enzyme of heme biosynthesis
SY83_RS18685	COG2339	peptidase activity
SY83_RS18690	COG4862	establishment of competence for transformation
SY83_RS18710	COG1266	CAAX protease self-immunity
SY83_RS18725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SY83_RS18730	COG0577	efflux transmembrane transporter activity
SY83_RS18735	COG1136	(ABC) transporter
SY83_RS18745	COG1131	(ABC) transporter
SY83_RS18750	COG1725	Transcriptional regulator
SY83_RS18755	COG5002	protein histidine kinase activity
SY83_RS18755	COG5002	protein histidine kinase activity
SY83_RS18760	COG0745	RESPONSE REGULATOR receiver
SY83_RS18765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SY83_RS18770	COG1333	cytochrome c biogenesis protein
SY83_RS18775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SY83_RS18780	COG1187	pseudouridine synthase activity
SY83_RS18785	COG0700	Nucleoside recognition
SY83_RS18790	COG2715	membrane protein required for spore maturation
SY83_RS18795	COG1686	Belongs to the peptidase S11 family
SY83_RS18800	COG3874	Sporulation protein YtfJ
SY83_RS18815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SY83_RS18820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SY83_RS18825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SY83_RS18830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SY83_RS18830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SY83_RS18835	COG0307	riboflavin synthase, alpha
SY83_RS18840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SY83_RS18840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SY83_RS18845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SY83_RS18855	COG0019	diaminopimelate decarboxylase activity
SY83_RS18880	COG2172	sigma factor antagonist activity
SY83_RS18885	COG1366	Belongs to the anti-sigma-factor antagonist family
SY83_RS18890	COG1686	Belongs to the peptidase S11 family
SY83_RS18905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SY83_RS18920	COG4974	Belongs to the 'phage' integrase family
SY83_RS18935	COG0735	belongs to the Fur family
SY83_RS18940	COG1300	Membrane
SY83_RS18955	COG1595	DNA-templated transcription, initiation
SY83_RS18960	COG0277	FAD linked oxidase domain protein
SY83_RS18965	COG2271	Major facilitator Superfamily
SY83_RS18995	COG1379	DNA repair
SY83_RS19015	COG2195	Cleaves the N-terminal amino acid of tripeptides
SY83_RS19020	COG0321	lipoyl(octanoyl) transferase activity
SY83_RS19025	COG0508	dehydrogenase complex catalyzes the overall conversion of
SY83_RS19030	COG0022	dehydrogenase e1 component
SY83_RS19035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SY83_RS19040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SY83_RS19050	COG3973	AAA domain
SY83_RS19075	COG3285	dna ligase
SY83_RS19075	COG1793	dna ligase
SY83_RS19090	COG3852	Histidine kinase
SY83_RS19095	COG3764	Sortase (surface protein transpeptidase)
SY83_RS19120	COG0745	RESPONSE REGULATOR receiver
SY83_RS19125	COG0750	zinc metalloprotease
SY83_RS19130	COG0497	DNA recombination
SY83_RS19135	COG1438	arginine binding
SY83_RS19145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SY83_RS19150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SY83_RS19170	COG1570	exodeoxyribonuclease VII activity
SY83_RS19175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SY83_RS19195	COG1302	Protein conserved in bacteria
SY83_RS19200	COG0439	Biotin carboxylase
SY83_RS19205	COG0511	ligase activity, forming carbon-carbon bonds
SY83_RS19245	COG3854	ATPases associated with a variety of cellular activities
SY83_RS19255	COG1809	phosphosulfolactate synthase activity
SY83_RS19260	COG2045	Belongs to the ComB family
SY83_RS19265	COG2707	UPF0756 membrane protein
SY83_RS19275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SY83_RS19280	COG0006	proline dipeptidase activity
SY83_RS19285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SY83_RS19290	COG3872	metal-dependent enzyme
SY83_RS19300	COG1752	Esterase of the alpha-beta hydrolase superfamily
SY83_RS19305	COG1321	iron dependent repressor
SY83_RS19310	COG1533	DNA photolyase activity
SY83_RS19315	COG0785	Cytochrome C biogenesis protein
SY83_RS19320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SY83_RS19325	COG1121	(ABC) transporter
SY83_RS19330	COG3443	Belongs to the bacterial solute-binding protein 9 family
SY83_RS19330	COG0803	Belongs to the bacterial solute-binding protein 9 family
SY83_RS19345	COG0735	belongs to the Fur family
SY83_RS19350	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SY83_RS19370	COG0697	spore germination
SY83_RS19375	COG2261	transglycosylase associated protein
SY83_RS19395	COG0628	permease
SY83_RS19405	COG1191	sigma factor activity
SY83_RS19415	COG0783	Belongs to the Dps family
SY83_RS19420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SY83_RS19425	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SY83_RS19430	COG1191	sigma factor activity
SY83_RS19455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SY83_RS19460	COG2205	protein histidine kinase activity
SY83_RS19460	COG5002	protein histidine kinase activity
SY83_RS19460	COG0784	Response regulator, receiver
SY83_RS19465	COG2208	phosphoserine phosphatase activity
SY83_RS19480	COG0697	spore germination
SY83_RS19490	COG0243	molybdopterin cofactor binding
SY83_RS19495	COG2146	nitrite reductase [NAD(P)H] activity
SY83_RS19500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SY83_RS19505	COG2223	nitrite transmembrane transporter activity
SY83_RS19510	COG3707	response regulator
SY83_RS19515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SY83_RS19520	COG0572	uridine kinase
SY83_RS19525	COG2814	Major facilitator Superfamily
SY83_RS19535	COG0004	ammonium transporteR
SY83_RS19545	COG1595	DNA-templated transcription, initiation
SY83_RS19555	COG0701	Predicted permease
SY83_RS19575	COG1979	alcohol dehydrogenase
SY83_RS19595	COG0666	response to abiotic stimulus
SY83_RS19605	COG0745	RESPONSE REGULATOR receiver
SY83_RS19615	COG0456	acetyltransferase
SY83_RS19620	COG1607	acyl-coa hydrolase
SY83_RS19630	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS19640	COG1233	COG1233 Phytoene dehydrogenase and related
SY83_RS19645	COG0667	Aldo Keto reductase
SY83_RS19650	COG0720	synthase
SY83_RS19655	COG1307	EDD domain protein, DegV family
SY83_RS19660	COG4129	membrane
SY83_RS19670	COG2340	Cysteine-rich secretory protein family
SY83_RS19680	COG1132	(ABC) transporter
SY83_RS19685	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
SY83_RS19695	COG0531	amino acid
SY83_RS19705	COG2861	carbohydrate metabolic process
SY83_RS19715	COG1126	abc transporter atp-binding protein
SY83_RS19720	COG0765	amino acid transport
SY83_RS19725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SY83_RS19740	COG1956	GAF domain-containing protein
SY83_RS19745	COG3104	oligopeptide transport
SY83_RS19795	COG3973	AAA domain
SY83_RS19800	COG0583	DNA-binding transcription factor activity
SY83_RS19805	COG1428	Deoxynucleoside kinase
SY83_RS19820	COG0477	Major facilitator Superfamily
SY83_RS19830	COG0789	Transcriptional regulator
SY83_RS19845	COG0596	Alpha beta hydrolase
SY83_RS19870	COG0697	spore germination
SY83_RS19885	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS19895	COG1733	regulation of RNA biosynthetic process
SY83_RS19925	COG5285	phytanoyl-CoA dioxygenase
SY83_RS19935	COG1069	ribulokinase activity
SY83_RS19965	COG2207	Transcriptional regulator
SY83_RS19965	COG4753	response regulator
SY83_RS19970	COG3275	phosphorelay sensor kinase activity
SY83_RS19980	COG3940	Belongs to the glycosyl hydrolase 43 family
SY83_RS19985	COG3833	ABC-type maltose transport systems, permease component
SY83_RS19990	COG1175	transmembrane transport
SY83_RS20000	COG3250	beta-galactosidase activity
SY83_RS20020	COG0247	lactate metabolic process
SY83_RS20025	COG0277	FAD linked oxidase domain protein
SY83_RS20030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SY83_RS20035	COG1472	Belongs to the glycosyl hydrolase 3 family
SY83_RS20040	COG2971	BadF BadG BcrA BcrD
SY83_RS20045	COG3876	Protein conserved in bacteria
SY83_RS20050	COG0395	ABC-type sugar transport system, permease component
SY83_RS20055	COG1175	transmembrane transport
SY83_RS20065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SY83_RS20070	COG1737	Transcriptional regulator
SY83_RS20075	COG1486	melibiose metabolic process
SY83_RS20095	COG1522	sequence-specific DNA binding
SY83_RS20105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SY83_RS20115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SY83_RS20120	COG0306	phosphate transporter
SY83_RS20125	COG1392	Phosphate transport regulator
SY83_RS20130	COG2706	6-phosphogluconolactonase activity
SY83_RS20135	COG0753	catalase activity
SY83_RS20150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SY83_RS20165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SY83_RS20170	COG0628	permease
SY83_RS20175	COG4221	oxidoreductase activity
SY83_RS20185	COG0640	Transcriptional regulator
SY83_RS20190	COG0367	asparagine synthase
SY83_RS20200	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS20200	COG2207	Transcriptional regulator
SY83_RS20205	COG4733	cellulase activity
SY83_RS20205	COG5297	Belongs to the glycosyl hydrolase family 6
SY83_RS20220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SY83_RS20230	COG1063	alcohol dehydrogenase
SY83_RS20240	COG1609	Transcriptional regulator
SY83_RS20250	COG0657	acetylesterase activity
SY83_RS20250	COG2755	lipolytic protein G-D-S-L family
SY83_RS20255	COG2197	response regulator
SY83_RS20260	COG2972	Histidine kinase
SY83_RS20265	COG0395	ABC-type sugar transport system, permease component
SY83_RS20270	COG4209	transmembrane transport
SY83_RS20320	COG0445	tRNA wobble uridine modification
SY83_RS20325	COG0395	ABC-type sugar transport system, permease component
SY83_RS20340	COG2207	Transcriptional regulator
SY83_RS20340	COG4753	response regulator
SY83_RS20345	COG2972	Histidine kinase
SY83_RS20355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SY83_RS20410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SY83_RS20415	COG3949	Membrane
SY83_RS20420	COG4717	serine-type aminopeptidase activity
SY83_RS20425	COG0420	3'-5' exonuclease activity
SY83_RS20430	COG0438	transferase activity, transferring glycosyl groups
SY83_RS20435	COG3706	GGDEF domain
SY83_RS20440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SY83_RS20445	COG0602	queuosine metabolic process
SY83_RS20455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS20460	COG0697	spore germination
SY83_RS20470	COG0561	phosphatase activity
SY83_RS20475	COG1187	pseudouridine synthase activity
SY83_RS20480	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SY83_RS20480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SY83_RS20485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SY83_RS20495	COG1547	Domain of unknown function (DUF309)
SY83_RS20500	COG2357	RelA SpoT domain protein
SY83_RS20505	COG0167	dihydroorotate dehydrogenase activity
SY83_RS20515	COG1141	Ferredoxin
SY83_RS20520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SY83_RS20525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SY83_RS20530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SY83_RS20535	COG2814	Major facilitator Superfamily
SY83_RS20540	COG2176	DNA-directed DNA polymerase activity
SY83_RS20550	COG0004	ammonium transporteR
SY83_RS20560	COG2738	Putative neutral zinc metallopeptidase
SY83_RS20565	COG0583	DNA-binding transcription factor activity
SY83_RS20570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SY83_RS20585	COG5578	integral membrane protein
SY83_RS20590	COG0513	Belongs to the DEAD box helicase family
SY83_RS20595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SY83_RS20620	COG0431	NADPH-dependent FMN reductase
SY83_RS20650	COG1278	Cold shock
SY83_RS20660	COG0028	Belongs to the TPP enzyme family
SY83_RS20670	COG1164	Oligoendopeptidase f
SY83_RS20675	COG1247	-acetyltransferase
SY83_RS20680	COG0561	phosphatase activity
SY83_RS20685	COG5416	Lipopolysaccharide assembly protein A domain
SY83_RS20690	COG1363	Peptidase, m42
SY83_RS20705	COG0488	(ABC) transporter
SY83_RS20720	COG0584	glycerophosphoryl diester phosphodiesterase
SY83_RS20730	COG5577	PFAM Coat F domain
SY83_RS20735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SY83_RS20755	COG1376	ErfK ybiS ycfS ynhG family protein
SY83_RS20760	COG4122	O-methyltransferase activity
SY83_RS20765	COG0116	Belongs to the methyltransferase superfamily
SY83_RS20770	COG1368	sulfuric ester hydrolase activity
SY83_RS20785	COG4844	belongs to the
SY83_RS20815	COG4555	ABC transporter
SY83_RS20825	COG4876	unkown
SY83_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS20835	COG1486	melibiose metabolic process
SY83_RS20840	COG2207	Transcriptional regulator
SY83_RS20860	COG1266	CAAX protease self-immunity
SY83_RS20880	COG5434	Belongs to the glycosyl hydrolase 28 family
SY83_RS20880	COG4632	Exopolysaccharide biosynthesis protein
SY83_RS20885	COG4980	gas vesicle protein
SY83_RS20920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SY83_RS20920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SY83_RS20925	COG4209	transmembrane transport
SY83_RS20935	COG0395	ABC-type sugar transport system, permease component
SY83_RS20940	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS20940	COG2207	Transcriptional regulator
SY83_RS20970	COG1028	Short-chain dehydrogenase reductase Sdr
SY83_RS20980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SY83_RS20990	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS20990	COG4977	sequence-specific DNA binding
SY83_RS21000	COG1253	flavin adenine dinucleotide binding
SY83_RS21005	COG0604	alcohol dehydrogenase
SY83_RS21010	COG1476	TRANSCRIPTIONal
SY83_RS21015	COG0277	FAD linked oxidase domain protein
SY83_RS21020	COG1309	transcriptional regulator
SY83_RS21040	COG1388	LysM domain
SY83_RS21040	COG1705	Flagellar rod assembly protein muramidase FlgJ
SY83_RS21045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SY83_RS21060	COG0237	dephospho-CoA kinase activity
SY83_RS21065	COG1971	Probably functions as a manganese efflux pump
SY83_RS21070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SY83_RS21075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SY83_RS21075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SY83_RS21085	COG0704	Plays a role in the regulation of phosphate uptake
SY83_RS21090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SY83_RS21095	COG0581	inorganic phosphate transmembrane transporter activity
SY83_RS21100	COG0573	inorganic phosphate transmembrane transporter activity
SY83_RS21105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SY83_RS21110	COG0840	transmembrane signaling receptor activity
SY83_RS21115	COG0450	alkyl hydroperoxide reductase
SY83_RS21135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SY83_RS21150	COG0647	UMP catabolic process
SY83_RS21155	COG1904	glucuronate isomerase
SY83_RS21160	COG2207	Transcriptional regulator
SY83_RS21160	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS21170	COG2962	Rard protein
SY83_RS21175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SY83_RS21175	COG0723	plastoquinol--plastocyanin reductase activity
SY83_RS21190	COG1054	Belongs to the UPF0176 family
SY83_RS21195	COG2972	Histidine kinase
SY83_RS21200	COG2207	Transcriptional regulator
SY83_RS21200	COG4753	response regulator
SY83_RS21210	COG1175	transmembrane transport
SY83_RS21215	COG0395	ABC-type sugar transport system, permease component
SY83_RS21230	COG0531	amino acid
SY83_RS21240	COG0395	ABC-type sugar transport system, permease component
SY83_RS21245	COG1175	transmembrane transport
SY83_RS21255	COG2972	Histidine kinase
SY83_RS21270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SY83_RS21295	COG0438	transferase activity, transferring glycosyl groups
SY83_RS21315	COG1846	Transcriptional regulator
SY83_RS21320	COG0400	carboxylic ester hydrolase activity
SY83_RS21325	COG0346	lactoylglutathione lyase activity
SY83_RS21350	COG0395	ABC-type sugar transport system, permease component
SY83_RS21355	COG4209	transmembrane transport
SY83_RS21365	COG2207	Transcriptional regulator
SY83_RS21370	COG2972	Histidine kinase
SY83_RS21385	COG2249	NAD(P)H dehydrogenase (quinone) activity
SY83_RS21395	COG1846	Transcriptional regulator
SY83_RS21400	COG0640	Transcriptional regulator
SY83_RS21405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SY83_RS21410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SY83_RS21420	COG3973	AAA domain
SY83_RS21425	COG1271	oxidase subunit
SY83_RS21430	COG1294	oxidase, subunit
SY83_RS21445	COG0673	inositol 2-dehydrogenase activity
SY83_RS21460	COG0745	RESPONSE REGULATOR receiver
SY83_RS21465	COG5002	protein histidine kinase activity
SY83_RS21470	COG0385	Bile acid
SY83_RS21490	COG0668	transmembrane transport
SY83_RS21505	COG0039	L-malate dehydrogenase activity
SY83_RS21510	COG0538	isocitrate dehydrogenase activity
SY83_RS21515	COG0372	Belongs to the citrate synthase family
SY83_RS21520	COG0248	Ppx GppA phosphatase
SY83_RS21525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SY83_RS21530	COG0628	permease
SY83_RS21535	COG3030	protein affecting phage T7 exclusion by the F plasmid
SY83_RS21545	COG0825	malonyl-CoA metabolic process
SY83_RS21550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SY83_RS21560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SY83_RS21585	COG4109	DRTGG domain
SY83_RS21595	COG3679	Belongs to the UPF0342 family
SY83_RS21600	COG0189	ligase activity
SY83_RS21605	COG0189	ligase activity
SY83_RS21610	COG0189	ligase activity
SY83_RS21625	COG0189	ligase activity
SY83_RS21630	COG1253	flavin adenine dinucleotide binding
SY83_RS21635	COG0535	radical SAM domain protein
SY83_RS21645	COG0737	Belongs to the 5'-nucleotidase family
SY83_RS21655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SY83_RS21665	COG0314	molybdopterin synthase activity
SY83_RS21670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SY83_RS21680	COG0719	Fe-S assembly protein
SY83_RS21685	COG0822	iron-sulfur transferase activity
SY83_RS21690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SY83_RS21695	COG0719	Fe-S assembly protein
SY83_RS21700	COG0396	ATPase activity
SY83_RS21710	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SY83_RS21720	COG3377	Domain of unknown function (DUF1805)
SY83_RS21725	COG2363	Small membrane protein
SY83_RS21730	COG1063	alcohol dehydrogenase
SY83_RS21735	COG0303	'Molybdopterin
SY83_RS21740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SY83_RS21745	COG0243	molybdopterin cofactor binding
SY83_RS21760	COG0746	molybdenum cofactor guanylyltransferase activity
SY83_RS21770	COG1012	belongs to the aldehyde dehydrogenase family
SY83_RS21785	COG0167	dihydroorotate dehydrogenase activity
SY83_RS21785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SY83_RS21800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SY83_RS21810	COG1917	Cupin 2, conserved barrel domain protein
SY83_RS21810	COG2207	Transcriptional regulator
SY83_RS21825	COG1653	transport
SY83_RS21830	COG0395	ABC-type sugar transport system, permease component
SY83_RS21835	COG4209	transmembrane transport
SY83_RS21840	COG4753	response regulator
SY83_RS21840	COG2207	Transcriptional regulator
SY83_RS21845	COG2972	Histidine kinase
SY83_RS21860	COG0395	ABC-type sugar transport system, permease component
SY83_RS21865	COG4209	transmembrane transport
SY83_RS21870	COG2972	Histidine kinase
SY83_RS21880	COG1653	transport
SY83_RS21890	COG2718	Belongs to the UPF0229 family
SY83_RS21900	COG0730	response to heat
SY83_RS21905	COG3153	acetyltransferase
SY83_RS21905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SY83_RS21910	COG1126	abc transporter atp-binding protein
SY83_RS21915	COG4215	(ABC) transporter
SY83_RS21925	COG0084	hydrolase, TatD family'
SY83_RS21950	COG2719	SpoVR family
SY83_RS21965	COG4124	Belongs to the glycosyl hydrolase 26 family
SY83_RS21990	COG0395	ABC-type sugar transport system, permease component
SY83_RS21995	COG4209	transmembrane transport
SY83_RS22025	COG1472	Belongs to the glycosyl hydrolase 3 family
SY83_RS22035	COG4154	Belongs to the RbsD FucU family
SY83_RS22045	COG2076	Multidrug Resistance protein
SY83_RS22050	COG2076	Multidrug Resistance protein
SY83_RS22055	COG0506	proline dehydrogenase activity
SY83_RS22065	COG0653	protein targeting
SY83_RS22070	COG0581	inorganic phosphate transmembrane transporter activity
SY83_RS22075	COG0573	inorganic phosphate transmembrane transporter activity
SY83_RS22080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SY83_RS22095	COG0673	inositol 2-dehydrogenase activity
SY83_RS22100	COG2084	Dehydrogenase
SY83_RS22115	COG0534	Mate efflux family protein
SY83_RS22120	COG3739	integral membrane protein
SY83_RS22125	COG1876	peptidase activity
SY83_RS22130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SY83_RS22140	COG0673	inositol 2-dehydrogenase activity
SY83_RS22150	COG2766	serine protein kinase
SY83_RS22160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SY83_RS22180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SY83_RS22200	COG2972	Histidine kinase
SY83_RS22205	COG4753	response regulator
SY83_RS22205	COG2207	Transcriptional regulator
SY83_RS22210	COG2002	toxin-antitoxin pair type II binding
SY83_RS22220	COG0745	RESPONSE REGULATOR receiver
SY83_RS22230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SY83_RS22235	COG0398	Pfam SNARE associated Golgi protein
SY83_RS22240	COG0174	glutamine synthetase
SY83_RS22245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SY83_RS22255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SY83_RS22260	COG2205	protein histidine kinase activity
SY83_RS22265	COG0745	RESPONSE REGULATOR receiver
SY83_RS22270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SY83_RS22280	COG2197	response regulator
SY83_RS22285	COG4585	Histidine kinase
SY83_RS22290	COG4758	membrane
SY83_RS22295	COG3290	protein histidine kinase activity
SY83_RS22295	COG0840	transmembrane signaling receptor activity
SY83_RS22300	COG3584	3D domain protein
SY83_RS22305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SY83_RS22315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SY83_RS22325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SY83_RS22335	COG3424	synthase
SY83_RS22340	COG5001	Diguanylate cyclase
SY83_RS22345	COG0626	cystathionine gamma-synthase activity
SY83_RS22350	COG0626	cystathionine gamma-synthase activity
SY83_RS22355	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SY83_RS22360	COG0598	Magnesium transport protein CorA
SY83_RS22380	COG0129	dihydroxy-acid dehydratase activity
SY83_RS22385	COG4753	response regulator
SY83_RS22385	COG2207	Transcriptional regulator
SY83_RS22385	COG2207	Transcriptional regulator
SY83_RS22385	COG4753	response regulator
SY83_RS22390	COG3275	phosphorelay sensor kinase activity
SY83_RS22400	COG0395	ABC-type sugar transport system, permease component
SY83_RS22405	COG4209	transmembrane transport
SY83_RS22420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SY83_RS22425	COG0436	Aminotransferase
SY83_RS22430	COG1393	Belongs to the ArsC family
SY83_RS22435	COG0564	pseudouridine synthase activity
SY83_RS22440	COG2096	Adenosyltransferase
SY83_RS22450	COG0436	Aminotransferase
SY83_RS22455	COG1522	sequence-specific DNA binding
SY83_RS22470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SY83_RS22475	COG0477	Major facilitator Superfamily