locus-tag	class	description
IRI77_RS00070	COG0673	inositol 2-dehydrogenase activity
IRI77_RS00095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRI77_RS00100	COG0673	inositol 2-dehydrogenase activity
IRI77_RS00110	COG1414	Transcriptional regulator
IRI77_RS00120	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS00125	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS00140	COG0673	inositol 2-dehydrogenase activity
IRI77_RS00150	COG0515	serine threonine protein kinase
IRI77_RS00150	COG2815	serine threonine protein kinase
IRI77_RS00155	COG2373	Large extracellular alpha-helical protein
IRI77_RS00175	COG0673	inositol 2-dehydrogenase activity
IRI77_RS00240	COG0583	DNA-binding transcription factor activity
IRI77_RS00255	COG2890	protein-(glutamine-N5) methyltransferase activity
IRI77_RS00345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IRI77_RS00350	COG0493	'glutamate synthase
IRI77_RS00365	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS00390	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS00415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IRI77_RS00420	COG1874	Beta-galactosidase
IRI77_RS00440	COG1136	(ABC) transporter
IRI77_RS00440	COG0577	efflux transmembrane transporter activity
IRI77_RS00470	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IRI77_RS00475	COG3781	membrane
IRI77_RS00485	COG0745	RESPONSE REGULATOR receiver
IRI77_RS00490	COG2205	protein histidine kinase activity
IRI77_RS00500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS00530	COG4221	oxidoreductase activity
IRI77_RS00530	COG0604	alcohol dehydrogenase
IRI77_RS00530	COG3321	synthase
IRI77_RS00530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRI77_RS00535	COG2815	serine threonine protein kinase
IRI77_RS00535	COG0515	serine threonine protein kinase
IRI77_RS00595	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRI77_RS00625	COG0114	fumarate hydratase activity
IRI77_RS00635	COG1201	RNA secondary structure unwinding
IRI77_RS00655	COG1136	(ABC) transporter
IRI77_RS00655	COG0577	efflux transmembrane transporter activity
IRI77_RS00670	COG3279	Response regulator of the LytR AlgR family
IRI77_RS00675	COG3275	phosphorelay sensor kinase activity
IRI77_RS00680	COG3279	Response regulator of the LytR AlgR family
IRI77_RS00685	COG3275	phosphorelay sensor kinase activity
IRI77_RS00690	COG2267	carboxylic ester hydrolase activity
IRI77_RS00695	COG1902	pentaerythritol trinitrate reductase activity
IRI77_RS00705	COG0166	Belongs to the GPI family
IRI77_RS00715	COG0563	adenylate kinase activity
IRI77_RS00740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRI77_RS00755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IRI77_RS00760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IRI77_RS00765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IRI77_RS00825	COG0326	Molecular chaperone. Has ATPase activity
IRI77_RS00830	COG3259	Nickel-dependent hydrogenase
IRI77_RS00850	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IRI77_RS00855	COG0542	response to heat
IRI77_RS00860	COG0612	Peptidase, M16
IRI77_RS00880	COG0328	RNA-DNA hybrid ribonuclease activity
IRI77_RS00885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRI77_RS00890	COG5002	protein histidine kinase activity
IRI77_RS00895	COG0745	RESPONSE REGULATOR receiver
IRI77_RS00920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IRI77_RS00925	COG0509	glycine decarboxylation via glycine cleavage system
IRI77_RS00930	COG0437	4 iron, 4 sulfur cluster binding
IRI77_RS00930	COG3064	Membrane
IRI77_RS00935	COG5557	Pfam Polysulphide reductase, NrfD
IRI77_RS00940	COG3852	Histidine kinase
IRI77_RS00970	COG0557	exoribonuclease II activity
IRI77_RS00990	COG0463	Glycosyl transferase, family 2
IRI77_RS01000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRI77_RS01010	COG0653	protein targeting
IRI77_RS01015	COG0439	Biotin carboxylase
IRI77_RS01020	COG0511	ligase activity, forming carbon-carbon bonds
IRI77_RS01025	COG0006	proline dipeptidase activity
IRI77_RS01030	COG1506	peptidase
IRI77_RS01030	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRI77_RS01045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IRI77_RS01075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IRI77_RS01080	COG0577	efflux transmembrane transporter activity
IRI77_RS01080	COG1136	(ABC) transporter
IRI77_RS01100	COG4221	oxidoreductase activity
IRI77_RS01125	COG3959	Transketolase, thiamine diphosphate binding domain
IRI77_RS01130	COG3958	Transketolase
IRI77_RS01140	COG2390	Transcriptional regulator
IRI77_RS01150	COG1129	ABC transporter
IRI77_RS01155	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRI77_RS01200	COG2819	hydrolase of the alpha beta superfamily
IRI77_RS01205	COG3119	arylsulfatase activity
IRI77_RS01240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IRI77_RS01245	COG0022	dehydrogenase e1 component
IRI77_RS01275	COG3481	metal-dependent phosphohydrolase, HD sub domain
IRI77_RS01280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRI77_RS01305	COG2183	response to ionizing radiation
IRI77_RS01340	COG1082	Xylose isomerase domain protein TIM barrel
IRI77_RS01345	COG1063	alcohol dehydrogenase
IRI77_RS01350	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS01370	COG3250	beta-galactosidase activity
IRI77_RS01380	COG0673	inositol 2-dehydrogenase activity
IRI77_RS01390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IRI77_RS01400	COG2027	D-alanyl-D-alanine carboxypeptidase
IRI77_RS01410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRI77_RS01425	COG3622	Belongs to the hyi family
IRI77_RS01430	COG0668	transmembrane transport
IRI77_RS01445	COG2201	protein-glutamate methylesterase activity
IRI77_RS01455	COG0745	RESPONSE REGULATOR receiver
IRI77_RS01460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IRI77_RS01470	COG2198	Histidine kinase
IRI77_RS01470	COG0643	Histidine kinase
IRI77_RS01475	COG0840	transmembrane signaling receptor activity
IRI77_RS01480	COG0835	chemotaxis
IRI77_RS01485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRI77_RS01495	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS01520	COG0577	efflux transmembrane transporter activity
IRI77_RS01520	COG1136	(ABC) transporter
IRI77_RS01545	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IRI77_RS01545	COG2885	chlorophyll binding
IRI77_RS01575	COG3621	Patatin-like phospholipase
IRI77_RS01610	COG0577	efflux transmembrane transporter activity
IRI77_RS01610	COG1136	(ABC) transporter
IRI77_RS01700	COG1598	PFAM Uncharacterised protein family UPF0150
IRI77_RS01705	COG3119	arylsulfatase activity
IRI77_RS01710	COG3119	arylsulfatase activity
IRI77_RS01715	COG3119	arylsulfatase activity
IRI77_RS01725	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS01740	COG0577	efflux transmembrane transporter activity
IRI77_RS01740	COG1136	(ABC) transporter
IRI77_RS01750	COG3795	YCII-related domain
IRI77_RS01810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRI77_RS01815	COG0758	DNA mediated transformation
IRI77_RS01875	COG1331	Highly conserved protein containing a thioredoxin domain
IRI77_RS01880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IRI77_RS01900	COG0463	Glycosyl transferase, family 2
IRI77_RS01905	COG0297	glycogen (starch) synthase activity
IRI77_RS01910	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IRI77_RS01925	COG0575	Belongs to the CDS family
IRI77_RS01930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IRI77_RS01945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IRI77_RS01950	COG0488	(ABC) transporter
IRI77_RS01955	COG2234	aminopeptidase activity
IRI77_RS01975	COG0577	efflux transmembrane transporter activity
IRI77_RS02010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IRI77_RS02015	COG2201	protein-glutamate methylesterase activity
IRI77_RS02030	COG2267	carboxylic ester hydrolase activity
IRI77_RS02035	COG0577	efflux transmembrane transporter activity
IRI77_RS02035	COG1136	(ABC) transporter
IRI77_RS02090	COG2208	phosphoserine phosphatase activity
IRI77_RS02105	COG0741	lytic transglycosylase activity
IRI77_RS02130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IRI77_RS02150	COG0515	serine threonine protein kinase
IRI77_RS02175	COG0443	Heat shock 70 kDa protein
IRI77_RS02185	COG3507	Belongs to the glycosyl hydrolase 43 family
IRI77_RS02190	COG2271	Major facilitator Superfamily
IRI77_RS02205	COG3250	beta-galactosidase activity
IRI77_RS02210	COG4585	Histidine kinase
IRI77_RS02215	COG2197	response regulator
IRI77_RS02250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS02265	COG2815	serine threonine protein kinase
IRI77_RS02265	COG0515	serine threonine protein kinase
IRI77_RS02280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IRI77_RS02290	COG1131	(ABC) transporter
IRI77_RS02310	COG1361	Conserved repeat domain
IRI77_RS02330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRI77_RS02335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRI77_RS02340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IRI77_RS02350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS02370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRI77_RS02375	COG0493	'glutamate synthase
IRI77_RS02395	COG0515	serine threonine protein kinase
IRI77_RS02410	COG1785	Belongs to the alkaline phosphatase family
IRI77_RS02425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRI77_RS02435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRI77_RS02440	COG1684	flagellar biosynthetic protein fliR
IRI77_RS02445	COG4794	Type iii secretion
IRI77_RS02465	COG1749	Flagellar hook protein flgE
IRI77_RS02480	COG4786	Flagellar basal body rod
IRI77_RS02485	COG4786	Flagellar basal body rod
IRI77_RS02495	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IRI77_RS02500	COG1706	bacterial-type flagellum-dependent cell motility
IRI77_RS02515	COG3604	Transcriptional regulator
IRI77_RS02520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRI77_RS02530	COG1191	sigma factor activity
IRI77_RS02535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS02535	COG1776	CheC inhibitor of MCP methylation
IRI77_RS02560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRI77_RS02580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRI77_RS02585	COG1360	Flagellar Motor Protein
IRI77_RS02590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRI77_RS02600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRI77_RS02605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRI77_RS02620	COG1815	bacterial-type flagellum-dependent cell motility
IRI77_RS02625	COG1558	bacterial-type flagellum-dependent cell motility
IRI77_RS02630	COG1677	Flagellar hook-basal body complex protein FliE
IRI77_RS02635	COG1766	The M ring may be actively involved in energy transduction
IRI77_RS02640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS02650	COG1157	protein secretion by the type III secretion system
IRI77_RS02665	COG3920	Histidine kinase
IRI77_RS02675	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRI77_RS02680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRI77_RS02685	COG0492	ferredoxin-NADP+ reductase activity
IRI77_RS02735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IRI77_RS02775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IRI77_RS02825	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IRI77_RS02835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRI77_RS02880	COG1051	belongs to the nudix hydrolase family
IRI77_RS02890	COG2223	nitrite transmembrane transporter activity
IRI77_RS02895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IRI77_RS02935	COG1404	Belongs to the peptidase S8 family
IRI77_RS02965	COG0538	isocitrate dehydrogenase activity
IRI77_RS02980	COG0673	inositol 2-dehydrogenase activity
IRI77_RS02985	COG0105	UTP biosynthetic process
IRI77_RS02990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRI77_RS02995	COG0045	succinate-CoA ligase (ADP-forming) activity
IRI77_RS03000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRI77_RS03010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IRI77_RS03020	COG0363	glucosamine-6-phosphate deaminase activity
IRI77_RS03045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRI77_RS03060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IRI77_RS03105	COG3604	Transcriptional regulator
IRI77_RS03110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IRI77_RS03110	COG1017	nitric oxide dioxygenase activity
IRI77_RS03125	COG1683	Conserved Protein
IRI77_RS03130	COG0655	NAD(P)H dehydrogenase (quinone) activity
IRI77_RS03155	COG5549	protein import
IRI77_RS03155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS03170	COG3250	beta-galactosidase activity
IRI77_RS03200	COG4716	Myosin-crossreactive antigen
IRI77_RS03210	COG0589	response to stress
IRI77_RS03220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IRI77_RS03225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IRI77_RS03230	COG0517	IMP dehydrogenase activity
IRI77_RS03230	COG1994	Peptidase M50
IRI77_RS03270	COG4946	Tricorn protease homolog
IRI77_RS03270	COG0793	Belongs to the peptidase S41A family
IRI77_RS03275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRI77_RS03290	COG0564	pseudouridine synthase activity
IRI77_RS03305	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS03335	COG3415	Transposase
IRI77_RS03335	COG2801	Transposase and inactivated derivatives
IRI77_RS03350	COG2176	DNA-directed DNA polymerase activity
IRI77_RS03370	COG2815	serine threonine protein kinase
IRI77_RS03370	COG0515	serine threonine protein kinase
IRI77_RS03375	COG0137	argininosuccinate synthase activity
IRI77_RS03420	COG3511	phospholipase C
IRI77_RS03425	COG1335	isochorismatase
IRI77_RS03430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRI77_RS03450	COG0346	lactoylglutathione lyase activity
IRI77_RS03455	COG0400	carboxylic ester hydrolase activity
IRI77_RS03470	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS03480	COG3250	beta-galactosidase activity
IRI77_RS03485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS03495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRI77_RS03500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRI77_RS03505	COG0512	Glutamine amidotransferase of anthranilate synthase
IRI77_RS03525	COG2193	ferroxidase activity
IRI77_RS03530	COG0653	protein targeting
IRI77_RS03540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRI77_RS03545	COG0277	FAD linked oxidase domain protein
IRI77_RS03590	COG2081	HI0933 family
IRI77_RS03610	COG1214	PFAM Peptidase M22, glycoprotease
IRI77_RS03630	COG0673	inositol 2-dehydrogenase activity
IRI77_RS03655	COG0405	Gamma-glutamyltransferase
IRI77_RS03660	COG0546	phosphoglycolate phosphatase activity
IRI77_RS03675	COG0646	methionine synthase
IRI77_RS03675	COG1410	methionine synthase
IRI77_RS03680	COG3119	arylsulfatase activity
IRI77_RS03685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRI77_RS03695	COG1472	Belongs to the glycosyl hydrolase 3 family
IRI77_RS03715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRI77_RS03735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRI77_RS03740	COG0668	transmembrane transport
IRI77_RS03765	COG5002	protein histidine kinase activity
IRI77_RS03770	COG2204	response regulator
IRI77_RS03785	COG5002	protein histidine kinase activity
IRI77_RS03795	COG2721	sulfolactate sulfo-lyase activity
IRI77_RS03805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IRI77_RS03810	COG0542	response to heat
IRI77_RS03820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRI77_RS03825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IRI77_RS03830	COG0181	hydroxymethylbilane synthase activity
IRI77_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS03845	COG0531	amino acid
IRI77_RS03855	COG2204	response regulator
IRI77_RS03875	COG4206	TonB-dependent receptor
IRI77_RS03885	COG1522	sequence-specific DNA binding
IRI77_RS03890	COG0697	spore germination
IRI77_RS03935	COG0525	valine-tRNA ligase activity
IRI77_RS03945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IRI77_RS03945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IRI77_RS03955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IRI77_RS03970	COG1435	thymidine kinase activity
IRI77_RS03995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS04000	COG2080	2 iron, 2 sulfur cluster binding
IRI77_RS04025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IRI77_RS04030	COG0101	tRNA pseudouridine synthase activity
IRI77_RS04065	COG1136	(ABC) transporter
IRI77_RS04065	COG0577	efflux transmembrane transporter activity
IRI77_RS04075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRI77_RS04115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRI77_RS04120	COG0531	amino acid
IRI77_RS04125	COG3876	Protein conserved in bacteria
IRI77_RS04130	COG2154	pterin-4-alpha-carbinolamine dehydratase
IRI77_RS04135	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS04150	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRI77_RS04155	COG0315	cyclic pyranopterin monophosphate synthase activity
IRI77_RS04160	COG0303	'Molybdopterin
IRI77_RS04165	COG0154	amidase activity
IRI77_RS04170	COG0612	Peptidase, M16
IRI77_RS04195	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS04200	COG2264	protein methyltransferase activity
IRI77_RS04205	COG0318	PFAM AMP-dependent synthetase and ligase
IRI77_RS04235	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS04260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRI77_RS04315	COG1139	Iron-sulfur cluster binding protein
IRI77_RS04320	COG1556	Lactate utilization protein
IRI77_RS04360	COG0577	efflux transmembrane transporter activity
IRI77_RS04365	COG1904	glucuronate isomerase
IRI77_RS04440	COG2814	Major facilitator Superfamily
IRI77_RS04530	COG0083	homoserine kinase activity
IRI77_RS04535	COG0673	inositol 2-dehydrogenase activity
IRI77_RS04555	COG4977	sequence-specific DNA binding
IRI77_RS04580	COG1073	alpha beta
IRI77_RS04615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IRI77_RS04655	COG0714	Associated with various cellular activities
IRI77_RS04660	COG0012	GTP binding
IRI77_RS04680	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IRI77_RS04685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IRI77_RS04700	COG1815	bacterial-type flagellum-dependent cell motility
IRI77_RS04710	COG1677	Flagellar hook-basal body complex protein FliE
IRI77_RS04720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS04730	COG1157	protein secretion by the type III secretion system
IRI77_RS04745	COG0416	fatty acid biosynthetic process
IRI77_RS04750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IRI77_RS04765	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS04775	COG2197	response regulator
IRI77_RS04785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRI77_RS04795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRI77_RS04810	COG0631	protein serine/threonine phosphatase activity
IRI77_RS04815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS04845	COG3409	Peptidoglycan-binding domain 1 protein
IRI77_RS04845	COG0793	Belongs to the peptidase S41A family
IRI77_RS04850	COG2815	serine threonine protein kinase
IRI77_RS04850	COG0515	serine threonine protein kinase
IRI77_RS04890	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IRI77_RS05025	COG0101	tRNA pseudouridine synthase activity
IRI77_RS05040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IRI77_RS05075	COG2814	Major facilitator Superfamily
IRI77_RS05085	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS05105	COG3177	Filamentation induced by cAMP protein fic
IRI77_RS05125	COG0531	amino acid
IRI77_RS05130	COG0531	amino acid
IRI77_RS05135	COG0352	thiamine-phosphate diphosphorylase activity
IRI77_RS05150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRI77_RS05155	COG1438	arginine binding
IRI77_RS05160	COG0165	Argininosuccinate lyase
IRI77_RS05165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IRI77_RS05265	COG4770	biotin carboxylase activity
IRI77_RS05270	COG0346	lactoylglutathione lyase activity
IRI77_RS05275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS05280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS05280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS05285	COG1703	isobutyryl-CoA mutase activity
IRI77_RS05290	COG0427	acetyl-CoA hydrolase
IRI77_RS05305	COG2313	pseudouridylate synthase activity
IRI77_RS05310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRI77_RS05320	COG1349	DNA-binding transcription factor activity
IRI77_RS05335	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IRI77_RS05355	COG3250	beta-galactosidase activity
IRI77_RS05395	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS05405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRI77_RS05445	COG0667	Aldo Keto reductase
IRI77_RS05450	COG1309	transcriptional regulator
IRI77_RS05460	COG3250	beta-galactosidase activity
IRI77_RS05470	COG2204	response regulator
IRI77_RS05495	COG1063	alcohol dehydrogenase
IRI77_RS05500	COG0156	8-amino-7-oxononanoate synthase activity
IRI77_RS05535	COG2234	aminopeptidase activity
IRI77_RS05540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IRI77_RS05545	COG1294	oxidase, subunit
IRI77_RS05550	COG1271	oxidase subunit
IRI77_RS05575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS05590	COG1595	DNA-templated transcription, initiation
IRI77_RS05605	COG0577	efflux transmembrane transporter activity
IRI77_RS05605	COG1136	(ABC) transporter
IRI77_RS05705	COG0714	Associated with various cellular activities
IRI77_RS05750	COG1136	(ABC) transporter
IRI77_RS05750	COG0577	efflux transmembrane transporter activity
IRI77_RS05800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IRI77_RS05805	COG3186	Phenylalanine-4-hydroxylase
IRI77_RS05825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRI77_RS05835	COG4585	Histidine kinase
IRI77_RS05845	COG0840	transmembrane signaling receptor activity
IRI77_RS05870	COG2373	Large extracellular alpha-helical protein
IRI77_RS05885	COG4499	WXG100 protein secretion system (Wss), protein YukC
IRI77_RS05885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRI77_RS05890	COG0824	Thioesterase
IRI77_RS05895	COG0314	molybdopterin synthase activity
IRI77_RS05920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IRI77_RS05925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IRI77_RS05930	COG0295	cytidine deaminase activity
IRI77_RS05935	COG0402	S-adenosylhomocysteine deaminase activity
IRI77_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS05960	COG0215	cysteine-tRNA ligase activity
IRI77_RS05965	COG2814	Major facilitator Superfamily
IRI77_RS05970	COG3345	alpha-galactosidase
IRI77_RS05975	COG0793	Belongs to the peptidase S41A family
IRI77_RS06005	COG0509	glycine decarboxylation via glycine cleavage system
IRI77_RS06010	COG5557	Pfam Polysulphide reductase, NrfD
IRI77_RS06015	COG0437	4 iron, 4 sulfur cluster binding
IRI77_RS06040	COG0577	efflux transmembrane transporter activity
IRI77_RS06040	COG1136	(ABC) transporter
IRI77_RS06065	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRI77_RS06070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IRI77_RS06100	COG1858	cytochrome C peroxidase
IRI77_RS06105	COG1309	transcriptional regulator
IRI77_RS06120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS06150	COG3850	Histidine kinase
IRI77_RS06155	COG2197	response regulator
IRI77_RS06170	COG3604	Transcriptional regulator
IRI77_RS06185	COG1136	(ABC) transporter
IRI77_RS06185	COG0577	efflux transmembrane transporter activity
IRI77_RS06215	COG5434	Belongs to the glycosyl hydrolase 28 family
IRI77_RS06220	COG1560	Kdo2-lipid A biosynthetic process
IRI77_RS06225	COG0482	sulfurtransferase activity
IRI77_RS06230	COG1104	cysteine desulfurase activity
IRI77_RS06240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRI77_RS06245	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRI77_RS06245	COG0646	methionine synthase
IRI77_RS06250	COG0009	L-threonylcarbamoyladenylate synthase
IRI77_RS06260	COG1692	metallophosphoesterase
IRI77_RS06285	COG0640	Transcriptional regulator
IRI77_RS06305	COG0515	serine threonine protein kinase
IRI77_RS06310	COG0693	protein deglycase activity
IRI77_RS06315	COG0275	rRNA processing
IRI77_RS06320	COG2271	Major facilitator Superfamily
IRI77_RS06330	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IRI77_RS06340	COG2197	response regulator
IRI77_RS06345	COG4585	Histidine kinase
IRI77_RS06365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRI77_RS06370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IRI77_RS06375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IRI77_RS06380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRI77_RS06405	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS06445	COG1414	Transcriptional regulator
IRI77_RS06475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRI77_RS06480	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IRI77_RS06485	COG5002	protein histidine kinase activity
IRI77_RS06490	COG2204	response regulator
IRI77_RS06515	COG3344	reverse transcriptase
IRI77_RS06520	COG0148	phosphopyruvate hydratase activity
IRI77_RS06525	COG0588	phosphoglycerate mutase activity
IRI77_RS06530	COG2205	protein histidine kinase activity
IRI77_RS06530	COG0784	Response regulator, receiver
IRI77_RS06535	COG3852	Histidine kinase
IRI77_RS06590	COG2304	oxidoreductase activity
IRI77_RS06635	COG0427	acetyl-CoA hydrolase
IRI77_RS06645	COG3005	denitrification pathway
IRI77_RS06665	COG2204	response regulator
IRI77_RS06690	COG0602	queuosine metabolic process
IRI77_RS06695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IRI77_RS06700	COG2223	nitrite transmembrane transporter activity
IRI77_RS06715	COG1695	Transcriptional regulator
IRI77_RS06725	COG0028	Belongs to the TPP enzyme family
IRI77_RS06730	COG0440	acetolactate synthase activity
IRI77_RS06735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IRI77_RS06740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRI77_RS06760	COG0531	amino acid
IRI77_RS06780	COG4109	DRTGG domain
IRI77_RS06785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRI77_RS06800	COG1691	(AIR) carboxylase
IRI77_RS06830	COG3608	succinylglutamate desuccinylase aspartoacylase
IRI77_RS06830	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IRI77_RS06845	COG2837	iron assimilation
IRI77_RS06850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IRI77_RS06875	COG0492	ferredoxin-NADP+ reductase activity
IRI77_RS06880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRI77_RS06925	COG2207	Transcriptional regulator
IRI77_RS06965	COG0800	Aldolase
IRI77_RS06990	COG1519	Transferase
IRI77_RS06995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRI77_RS07005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IRI77_RS07020	COG2835	tetraacyldisaccharide 4'-kinase activity
IRI77_RS07025	COG0859	PFAM glycosyl transferase family 9
IRI77_RS07025	COG0859	PFAM glycosyl transferase family 9
IRI77_RS07030	COG1132	(ABC) transporter
IRI77_RS07035	COG1561	YicC-like family, N-terminal region
IRI77_RS07040	COG0194	GDP metabolic process
IRI77_RS07045	COG1758	RNA polymerase activity
IRI77_RS07050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRI77_RS07055	COG1573	uracil-dna glycosylase
IRI77_RS07060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IRI77_RS07070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IRI77_RS07075	COG0542	response to heat
IRI77_RS07085	COG0667	Aldo Keto reductase
IRI77_RS07105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRI77_RS07110	COG0495	leucyl-tRNA aminoacylation
IRI77_RS07150	COG0586	Pfam SNARE associated Golgi protein
IRI77_RS07175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IRI77_RS07185	COG0577	efflux transmembrane transporter activity
IRI77_RS07190	COG0577	efflux transmembrane transporter activity
IRI77_RS07190	COG1136	(ABC) transporter
IRI77_RS07200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRI77_RS07200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRI77_RS07205	COG0552	protein localization to endoplasmic reticulum
IRI77_RS07210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS07260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS07295	COG1595	DNA-templated transcription, initiation
IRI77_RS07340	COG1131	(ABC) transporter
IRI77_RS07375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS07395	COG0653	protein targeting
IRI77_RS07400	COG0359	binds to the 23S rRNA
IRI77_RS07405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IRI77_RS07410	COG0360	Binds together with S18 to 16S ribosomal RNA
IRI77_RS07415	COG0193	aminoacyl-tRNA hydrolase activity
IRI77_RS07420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IRI77_RS07425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRI77_RS07430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IRI77_RS07435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRI77_RS07440	COG1254	Belongs to the acylphosphatase family
IRI77_RS07450	COG0113	porphobilinogen synthase activity
IRI77_RS07465	COG3959	Transketolase, thiamine diphosphate binding domain
IRI77_RS07470	COG3958	Transketolase
IRI77_RS07480	COG2197	response regulator
IRI77_RS07500	COG3119	arylsulfatase activity
IRI77_RS07510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRI77_RS07515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS07530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IRI77_RS07530	COG4651	solute:proton antiporter activity
IRI77_RS07535	COG0840	transmembrane signaling receptor activity
IRI77_RS07550	COG0312	modulator of DNA gyrase
IRI77_RS07575	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRI77_RS07580	COG2226	methyltransferase
IRI77_RS07600	COG0038	chloride channel
IRI77_RS07605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IRI77_RS07610	COG2318	DinB family
IRI77_RS07615	COG2226	methyltransferase
IRI77_RS07620	COG0352	thiamine-phosphate diphosphorylase activity
IRI77_RS07635	COG4149	molybdate abc transporter
IRI77_RS07645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRI77_RS07660	COG0183	Belongs to the thiolase family
IRI77_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS07675	COG2204	response regulator
IRI77_RS07680	COG4191	Histidine kinase
IRI77_RS07735	COG4555	ABC transporter
IRI77_RS07770	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IRI77_RS07775	COG0298	carbon dioxide binding
IRI77_RS07780	COG0375	protein maturation
IRI77_RS07800	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IRI77_RS07810	COG4656	Part of a membrane complex involved in electron transport
IRI77_RS07815	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IRI77_RS07850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS07870	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IRI77_RS07875	COG0667	Aldo Keto reductase
IRI77_RS07900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRI77_RS07930	COG2010	Cytochrome c
IRI77_RS07930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS07950	COG0840	transmembrane signaling receptor activity
IRI77_RS07975	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS08015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRI77_RS08030	COG1994	Peptidase M50
IRI77_RS08040	COG0572	uridine kinase
IRI77_RS08045	COG1196	nuclear chromosome segregation
IRI77_RS08050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRI77_RS08075	COG1024	Enoyl-CoA hydratase
IRI77_RS08090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRI77_RS08095	COG1278	Cold shock
IRI77_RS08115	COG1845	cytochrome c oxidase, subunit III
IRI77_RS08120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRI77_RS08160	COG0437	4 iron, 4 sulfur cluster binding
IRI77_RS08170	COG4191	Histidine kinase
IRI77_RS08180	COG1136	(ABC) transporter
IRI77_RS08180	COG0577	efflux transmembrane transporter activity
IRI77_RS08195	COG2197	response regulator
IRI77_RS08210	COG1305	Transglutaminase-like
IRI77_RS08220	COG2308	Evidence 4 Homologs of previously reported genes of
IRI77_RS08225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IRI77_RS08240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRI77_RS08250	COG0506	proline dehydrogenase activity
IRI77_RS08310	COG0768	penicillin binding
IRI77_RS08315	COG0772	Belongs to the SEDS family
IRI77_RS08320	COG1530	ribonuclease E activity
IRI77_RS08320	COG1530	ribonuclease E activity
IRI77_RS08345	COG0577	efflux transmembrane transporter activity
IRI77_RS08345	COG1136	(ABC) transporter
IRI77_RS08350	COG1280	lysine exporter protein (LysE YggA)
IRI77_RS08360	COG1136	(ABC) transporter
IRI77_RS08360	COG0577	efflux transmembrane transporter activity
IRI77_RS08365	COG0577	efflux transmembrane transporter activity
IRI77_RS08365	COG1136	(ABC) transporter
IRI77_RS08375	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS08380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IRI77_RS08400	COG0657	acetylesterase activity
IRI77_RS08420	COG1595	DNA-templated transcription, initiation
IRI77_RS08430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IRI77_RS08485	COG4964	Belongs to the GSP D family
IRI77_RS08530	COG1136	(ABC) transporter
IRI77_RS08555	COG3119	arylsulfatase activity
IRI77_RS08560	COG0577	efflux transmembrane transporter activity
IRI77_RS08560	COG1136	(ABC) transporter
IRI77_RS08565	COG1940	carbohydrate kinase activity
IRI77_RS08585	COG3409	Peptidoglycan-binding domain 1 protein
IRI77_RS08585	COG3773	Cell wall hydrolase
IRI77_RS08595	COG0673	inositol 2-dehydrogenase activity
IRI77_RS08615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IRI77_RS08620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IRI77_RS08625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IRI77_RS08630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRI77_RS08640	COG0131	Imidazoleglycerol-phosphate dehydratase
IRI77_RS08650	COG0107	imidazoleglycerol-phosphate synthase activity
IRI77_RS08655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IRI77_RS08675	COG0546	phosphoglycolate phosphatase activity
IRI77_RS08680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRI77_RS08685	COG0037	tRNA processing
IRI77_RS08760	COG2382	esterase
IRI77_RS08765	COG2382	esterase
IRI77_RS08855	COG0577	efflux transmembrane transporter activity
IRI77_RS08855	COG1136	(ABC) transporter
IRI77_RS08895	COG4566	intracellular signal transduction
IRI77_RS08915	COG2382	esterase
IRI77_RS08945	COG1725	Transcriptional regulator
IRI77_RS08950	COG1131	(ABC) transporter
IRI77_RS08995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IRI77_RS09065	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IRI77_RS09070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRI77_RS09090	COG0612	Peptidase, M16
IRI77_RS09095	COG0402	S-adenosylhomocysteine deaminase activity
IRI77_RS09100	COG1228	amidohydrolase
IRI77_RS09120	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IRI77_RS09125	COG3119	arylsulfatase activity
IRI77_RS09140	COG3852	Histidine kinase
IRI77_RS09155	COG0745	RESPONSE REGULATOR receiver
IRI77_RS09165	COG1404	Belongs to the peptidase S8 family
IRI77_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS09180	COG4555	ABC transporter
IRI77_RS09185	COG1668	transmembrane transport
IRI77_RS09235	COG3275	phosphorelay sensor kinase activity
IRI77_RS09240	COG3279	Response regulator of the LytR AlgR family
IRI77_RS09245	COG1131	(ABC) transporter
IRI77_RS09250	COG0842	Transport permease protein
IRI77_RS09285	COG1609	Transcriptional regulator
IRI77_RS09290	COG3718	enzyme involved in inositol metabolism
IRI77_RS09295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRI77_RS09310	COG1012	belongs to the aldehyde dehydrogenase family
IRI77_RS09315	COG1082	Xylose isomerase domain protein TIM barrel
IRI77_RS09320	COG0673	inositol 2-dehydrogenase activity
IRI77_RS09355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IRI77_RS09360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRI77_RS09370	COG2271	Major facilitator Superfamily
IRI77_RS09390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS09395	COG0673	inositol 2-dehydrogenase activity
IRI77_RS09410	COG0583	DNA-binding transcription factor activity
IRI77_RS09420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS09425	COG2181	nitrate reductase activity
IRI77_RS09425	COG0247	lactate metabolic process
IRI77_RS09445	COG3940	Belongs to the glycosyl hydrolase 43 family
IRI77_RS09450	COG1733	regulation of RNA biosynthetic process
IRI77_RS09460	COG0662	Cupin 2, conserved barrel domain protein
IRI77_RS09465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IRI77_RS09505	COG2267	carboxylic ester hydrolase activity
IRI77_RS09545	COG0657	acetylesterase activity
IRI77_RS09545	COG2755	lipolytic protein G-D-S-L family
IRI77_RS09560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IRI77_RS09595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRI77_RS09615	COG3254	rhamnose metabolic process
IRI77_RS09655	COG1940	carbohydrate kinase activity
IRI77_RS09660	COG0531	amino acid
IRI77_RS09665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS09675	COG1609	Transcriptional regulator
IRI77_RS09685	COG2382	esterase
IRI77_RS09690	COG2382	esterase
IRI77_RS09740	COG3693	PFAM glycoside hydrolase, family 10
IRI77_RS09740	COG2382	esterase
IRI77_RS09745	COG2382	esterase
IRI77_RS09785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IRI77_RS09795	COG1104	cysteine desulfurase activity
IRI77_RS09805	COG0316	Belongs to the HesB IscA family
IRI77_RS09815	COG0443	Heat shock 70 kDa protein
IRI77_RS09820	COG2975	iron-sulfur cluster assembly
IRI77_RS09830	COG2204	response regulator
IRI77_RS09845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IRI77_RS09850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IRI77_RS09870	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IRI77_RS09875	COG0427	acetyl-CoA hydrolase
IRI77_RS09885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IRI77_RS09900	COG0577	efflux transmembrane transporter activity
IRI77_RS09905	COG1764	response to oxidative stress
IRI77_RS09930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRI77_RS09950	COG1136	(ABC) transporter
IRI77_RS09950	COG0577	efflux transmembrane transporter activity
IRI77_RS09955	COG2814	Major facilitator Superfamily
IRI77_RS09965	COG2020	methyltransferase activity
IRI77_RS09970	COG2832	Protein of unknown function (DUF454)
IRI77_RS10035	COG0673	inositol 2-dehydrogenase activity
IRI77_RS10060	COG2010	Cytochrome c
IRI77_RS10065	COG1063	alcohol dehydrogenase
IRI77_RS10085	COG1959	2 iron, 2 sulfur cluster binding
IRI77_RS10090	COG1732	Glycine betaine
IRI77_RS10110	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IRI77_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRI77_RS10125	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IRI77_RS10130	COG0577	efflux transmembrane transporter activity
IRI77_RS10130	COG1136	(ABC) transporter
IRI77_RS10135	COG1136	(ABC) transporter
IRI77_RS10145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IRI77_RS10150	COG1940	carbohydrate kinase activity
IRI77_RS10195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IRI77_RS10215	COG2813	Specifically methylates the guanine in position
IRI77_RS10215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IRI77_RS10220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IRI77_RS10225	COG0864	Transcriptional regulator
IRI77_RS10235	COG0505	Belongs to the CarA family
IRI77_RS10240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRI77_RS10255	COG0673	inositol 2-dehydrogenase activity
IRI77_RS10260	COG0673	inositol 2-dehydrogenase activity
IRI77_RS10270	COG1606	tRNA processing
IRI77_RS10325	COG0702	epimerase
IRI77_RS10360	COG3119	arylsulfatase activity
IRI77_RS10395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IRI77_RS10430	COG4221	oxidoreductase activity
IRI77_RS10435	COG2207	Transcriptional regulator
IRI77_RS10495	COG0515	serine threonine protein kinase
IRI77_RS10495	COG2815	serine threonine protein kinase
IRI77_RS10510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IRI77_RS10520	COG0577	efflux transmembrane transporter activity
IRI77_RS10520	COG1136	(ABC) transporter
IRI77_RS10555	COG1695	Transcriptional regulator
IRI77_RS10570	COG1413	lyase activity
IRI77_RS10595	COG3344	reverse transcriptase
IRI77_RS10645	COG0306	phosphate transporter
IRI77_RS10660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS10710	COG1091	dTDP-4-dehydrorhamnose reductase activity
IRI77_RS10730	COG0583	DNA-binding transcription factor activity
IRI77_RS10775	COG2770	Histidine kinase
IRI77_RS10775	COG2208	phosphoserine phosphatase activity
IRI77_RS10785	COG0671	phosphoesterase, PA-phosphatase related
IRI77_RS10830	COG4585	Histidine kinase
IRI77_RS10855	COG0583	DNA-binding transcription factor activity
IRI77_RS10860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRI77_RS10870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IRI77_RS10875	COG0066	3-isopropylmalate dehydratase activity
IRI77_RS10885	COG2770	Histidine kinase
IRI77_RS10885	COG2208	phosphoserine phosphatase activity
IRI77_RS10895	COG2208	phosphoserine phosphatase activity
IRI77_RS10920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IRI77_RS10930	COG1960	acyl-CoA dehydrogenase activity
IRI77_RS10940	COG0277	FAD linked oxidase domain protein
IRI77_RS10945	COG0247	lactate metabolic process
IRI77_RS10955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS10965	COG0442	prolyl-tRNA aminoacylation
IRI77_RS10980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IRI77_RS10985	COG0085	RNA polymerase activity
IRI77_RS10990	COG0222	ribosome binding
IRI77_RS10995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IRI77_RS11000	COG0081	regulation of translation
IRI77_RS11005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IRI77_RS11025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IRI77_RS11085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IRI77_RS11090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IRI77_RS11090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IRI77_RS11110	COG0859	PFAM glycosyl transferase family 9
IRI77_RS11125	COG0254	rRNA binding
IRI77_RS11155	COG0531	amino acid
IRI77_RS11160	COG2226	methyltransferase
IRI77_RS11180	COG1216	Glycosyl transferase, family 2
IRI77_RS11190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRI77_RS11200	COG1252	NADH dehydrogenase
IRI77_RS11260	COG0644	oxidoreductase
IRI77_RS11265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRI77_RS11295	COG2223	nitrite transmembrane transporter activity
IRI77_RS11320	COG0018	arginyl-trna synthetase
IRI77_RS11325	COG0633	Ferredoxin
IRI77_RS11345	COG0237	dephospho-CoA kinase activity
IRI77_RS11350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IRI77_RS11380	COG3415	Transposase
IRI77_RS11380	COG2801	Transposase and inactivated derivatives
IRI77_RS11390	COG0024	Methionine aminopeptidase
IRI77_RS11465	COG1136	(ABC) transporter
IRI77_RS11475	COG1538	Outer membrane efflux protein
IRI77_RS11485	COG3345	alpha-galactosidase
IRI77_RS11495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRI77_RS11500	COG2197	response regulator
IRI77_RS11525	COG2819	hydrolase of the alpha beta superfamily
IRI77_RS11535	COG0577	efflux transmembrane transporter activity
IRI77_RS11535	COG1136	(ABC) transporter
IRI77_RS11560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IRI77_RS11565	COG0484	heat shock protein binding
IRI77_RS11575	COG0431	NADPH-dependent FMN reductase
IRI77_RS11595	COG3385	transposase activity
IRI77_RS11605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRI77_RS11645	COG2070	2-Nitropropane dioxygenase
IRI77_RS11655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRI77_RS11665	COG0673	inositol 2-dehydrogenase activity
IRI77_RS11685	COG0577	efflux transmembrane transporter activity
IRI77_RS11685	COG1136	(ABC) transporter
IRI77_RS11695	COG1136	(ABC) transporter
IRI77_RS11695	COG0577	efflux transmembrane transporter activity
IRI77_RS11710	COG0577	efflux transmembrane transporter activity
IRI77_RS11710	COG1136	(ABC) transporter
IRI77_RS11715	COG1136	(ABC) transporter
IRI77_RS11715	COG0577	efflux transmembrane transporter activity
IRI77_RS11720	COG1136	(ABC) transporter
IRI77_RS11720	COG0577	efflux transmembrane transporter activity
IRI77_RS11730	COG0058	SHG alpha-glucan phosphorylase activity
IRI77_RS11735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRI77_RS11740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRI77_RS11745	COG2267	carboxylic ester hydrolase activity
IRI77_RS11785	COG1136	(ABC) transporter
IRI77_RS11785	COG0577	efflux transmembrane transporter activity
IRI77_RS11810	COG0640	Transcriptional regulator
IRI77_RS11825	COG3033	Beta-eliminating lyase
IRI77_RS11835	COG1136	(ABC) transporter
IRI77_RS11835	COG0577	efflux transmembrane transporter activity
IRI77_RS11845	COG2818	Glycosylase
IRI77_RS11850	COG1136	(ABC) transporter
IRI77_RS11850	COG0577	efflux transmembrane transporter activity
IRI77_RS11855	COG1695	Transcriptional regulator
IRI77_RS11905	COG3279	Response regulator of the LytR AlgR family
IRI77_RS11910	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS11915	COG1136	(ABC) transporter
IRI77_RS11915	COG0577	efflux transmembrane transporter activity
IRI77_RS11925	COG4717	serine-type aminopeptidase activity
IRI77_RS11930	COG0420	3'-5' exonuclease activity
IRI77_RS11935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRI77_RS11940	COG0668	transmembrane transport
IRI77_RS11970	COG0436	Aminotransferase
IRI77_RS12005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IRI77_RS12010	COG0450	alkyl hydroperoxide reductase
IRI77_RS12020	COG0657	acetylesterase activity
IRI77_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS12060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IRI77_RS12070	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS12085	COG1136	(ABC) transporter
IRI77_RS12085	COG0577	efflux transmembrane transporter activity
IRI77_RS12090	COG3415	Transposase
IRI77_RS12090	COG2801	Transposase and inactivated derivatives
IRI77_RS12150	COG0577	efflux transmembrane transporter activity
IRI77_RS12150	COG1136	(ABC) transporter
IRI77_RS12155	COG0477	Major facilitator Superfamily
IRI77_RS12180	COG0673	inositol 2-dehydrogenase activity
IRI77_RS12215	COG1131	(ABC) transporter
IRI77_RS12220	COG1136	(ABC) transporter
IRI77_RS12220	COG0577	efflux transmembrane transporter activity
IRI77_RS12225	COG3344	reverse transcriptase
IRI77_RS12245	COG2815	serine threonine protein kinase
IRI77_RS12245	COG0515	serine threonine protein kinase
IRI77_RS12250	COG5492	domain, Protein
IRI77_RS12250	COG4932	domain protein
IRI77_RS12260	COG0473	3-isopropylmalate dehydrogenase activity
IRI77_RS12265	COG0138	bifunctional purine biosynthesis protein purh
IRI77_RS12305	COG1136	(ABC) transporter
IRI77_RS12315	COG0577	efflux transmembrane transporter activity
IRI77_RS12315	COG1136	(ABC) transporter
IRI77_RS12350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IRI77_RS12355	COG0698	ribose 5-phosphate isomerase
IRI77_RS12370	COG1404	Belongs to the peptidase S8 family
IRI77_RS12380	COG1858	cytochrome C peroxidase
IRI77_RS12385	COG2205	protein histidine kinase activity
IRI77_RS12385	COG4999	Histidine kinase
IRI77_RS12385	COG3437	response regulator, receiver
IRI77_RS12385	COG3850	Histidine kinase
IRI77_RS12395	COG1404	Belongs to the peptidase S8 family
IRI77_RS12405	COG0444	Belongs to the ABC transporter superfamily
IRI77_RS12425	COG2204	response regulator
IRI77_RS12435	COG3250	beta-galactosidase activity
IRI77_RS12440	COG4941	Belongs to the sigma-70 factor family
IRI77_RS12460	COG0724	RNA recognition motif
IRI77_RS12465	COG4585	Histidine kinase
IRI77_RS12480	COG0442	prolyl-tRNA aminoacylation
IRI77_RS12500	COG2801	Transposase and inactivated derivatives
IRI77_RS12500	COG3415	Transposase
IRI77_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS12565	COG2267	carboxylic ester hydrolase activity
IRI77_RS12600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRI77_RS12605	COG1116	anion transmembrane transporter activity
IRI77_RS12620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRI77_RS12630	COG1970	mechanosensitive ion channel activity
IRI77_RS12680	COG2130	NADP-dependent
IRI77_RS12700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRI77_RS12715	COG0563	adenylate kinase activity
IRI77_RS12725	COG1136	(ABC) transporter
IRI77_RS12725	COG0577	efflux transmembrane transporter activity
IRI77_RS12765	COG1120	ATPase activity
IRI77_RS12775	COG2815	serine threonine protein kinase
IRI77_RS12775	COG0515	serine threonine protein kinase
IRI77_RS12830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS12845	COG4941	Belongs to the sigma-70 factor family
IRI77_RS12955	COG2226	methyltransferase
IRI77_RS12970	COG1136	(ABC) transporter
IRI77_RS12970	COG0577	efflux transmembrane transporter activity
IRI77_RS12980	COG4106	trans-aconitate 2-methyltransferase activity
IRI77_RS13005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IRI77_RS13015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRI77_RS13045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IRI77_RS13070	COG2814	Major facilitator Superfamily
IRI77_RS13080	COG3408	Glycogen debranching enzyme
IRI77_RS13085	COG0515	serine threonine protein kinase
IRI77_RS13085	COG2815	serine threonine protein kinase
IRI77_RS13090	COG5002	protein histidine kinase activity
IRI77_RS13095	COG1595	DNA-templated transcription, initiation
IRI77_RS13125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRI77_RS13130	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS13150	COG3940	Belongs to the glycosyl hydrolase 43 family
IRI77_RS13190	COG0129	dihydroxy-acid dehydratase activity
IRI77_RS13195	COG0673	inositol 2-dehydrogenase activity
IRI77_RS13200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IRI77_RS13215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IRI77_RS13220	COG0746	molybdenum cofactor guanylyltransferase activity
IRI77_RS13225	COG0741	lytic transglycosylase activity
IRI77_RS13230	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRI77_RS13250	COG1596	polysaccharide export
IRI77_RS13270	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS13275	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS13295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IRI77_RS13370	COG1131	(ABC) transporter
IRI77_RS13410	COG3537	Alpha-1,2-mannosidase
IRI77_RS13415	COG0577	efflux transmembrane transporter activity
IRI77_RS13430	COG0667	Aldo Keto reductase
IRI77_RS13435	COG0517	IMP dehydrogenase activity
IRI77_RS13435	COG1125	glycine betaine transport
IRI77_RS13440	COG1174	glycine betaine transport
IRI77_RS13490	COG1902	pentaerythritol trinitrate reductase activity
IRI77_RS13515	COG0318	PFAM AMP-dependent synthetase and ligase
IRI77_RS13530	COG1690	Belongs to the RtcB family
IRI77_RS13560	COG1695	Transcriptional regulator
IRI77_RS13575	COG0745	RESPONSE REGULATOR receiver
IRI77_RS13585	COG0577	efflux transmembrane transporter activity
IRI77_RS13585	COG1136	(ABC) transporter
IRI77_RS13595	COG1349	DNA-binding transcription factor activity
IRI77_RS13630	COG2222	sugar isomerase
IRI77_RS13635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRI77_RS13670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IRI77_RS13680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRI77_RS13695	COG1322	Protein conserved in bacteria
IRI77_RS13700	COG0640	Transcriptional regulator
IRI77_RS13835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IRI77_RS13840	COG1185	polyribonucleotide nucleotidyltransferase activity
IRI77_RS13905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IRI77_RS13910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRI77_RS13925	COG1132	(ABC) transporter
IRI77_RS13945	COG0242	peptide deformylase activity
IRI77_RS13980	COG1595	DNA-templated transcription, initiation
IRI77_RS13985	COG0436	Aminotransferase
IRI77_RS14025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IRI77_RS14030	COG4535	Mg2 and Co2 transporter CorC
IRI77_RS14035	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IRI77_RS14070	COG1073	alpha beta
IRI77_RS14085	COG1619	proteins homologs of microcin C7 resistance protein MccF
IRI77_RS14090	COG0657	acetylesterase activity
IRI77_RS14090	COG2755	lipolytic protein G-D-S-L family
IRI77_RS14105	COG0653	protein targeting
IRI77_RS14115	COG2204	response regulator
IRI77_RS14120	COG1404	Belongs to the peptidase S8 family
IRI77_RS14125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRI77_RS14125	COG2199	diguanylate cyclase activity
IRI77_RS14130	COG1994	Peptidase M50
IRI77_RS14185	COG1136	(ABC) transporter
IRI77_RS14185	COG0577	efflux transmembrane transporter activity
IRI77_RS14195	COG2967	ApaG domain
IRI77_RS14210	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS14255	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IRI77_RS14260	COG0243	molybdopterin cofactor binding
IRI77_RS14265	COG2223	nitrite transmembrane transporter activity
IRI77_RS14295	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS14315	COG3119	arylsulfatase activity
IRI77_RS14320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRI77_RS14325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IRI77_RS14330	COG1923	regulation of RNA biosynthetic process
IRI77_RS14335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRI77_RS14340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IRI77_RS14340	COG1796	DNA polymerase
IRI77_RS14345	COG0494	nUDIX hydrolase
IRI77_RS14350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IRI77_RS14355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IRI77_RS14380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IRI77_RS14385	COG1657	PFAM Prenyltransferase squalene oxidase
IRI77_RS14390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS14400	COG1063	alcohol dehydrogenase
IRI77_RS14405	COG1063	alcohol dehydrogenase
IRI77_RS14410	COG1562	ergosterol biosynthetic process
IRI77_RS14415	COG1562	ergosterol biosynthetic process
IRI77_RS14440	COG0457	Tetratricopeptide repeat
IRI77_RS14445	COG3408	Glycogen debranching enzyme
IRI77_RS14445	COG3119	arylsulfatase activity
IRI77_RS14450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRI77_RS14460	COG1506	peptidase
IRI77_RS14460	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS14460	COG4946	Tricorn protease homolog
IRI77_RS14465	COG0512	Glutamine amidotransferase of anthranilate synthase
IRI77_RS14465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IRI77_RS14475	COG1233	COG1233 Phytoene dehydrogenase and related
IRI77_RS14485	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IRI77_RS14505	COG2382	esterase
IRI77_RS14525	COG3795	YCII-related domain
IRI77_RS14540	COG3119	arylsulfatase activity
IRI77_RS14555	COG0673	inositol 2-dehydrogenase activity
IRI77_RS14595	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IRI77_RS14605	COG0463	Glycosyl transferase, family 2
IRI77_RS14610	COG0358	DNA primase activity
IRI77_RS14620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRI77_RS14625	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS14640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IRI77_RS14670	COG0126	phosphoglycerate kinase activity
IRI77_RS14685	COG3415	Transposase
IRI77_RS14685	COG2801	Transposase and inactivated derivatives
IRI77_RS14730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IRI77_RS14735	COG0464	growth
IRI77_RS14765	COG1309	transcriptional regulator
IRI77_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS14785	COG2197	response regulator
IRI77_RS14810	COG3209	COG3209 Rhs family protein
IRI77_RS14820	COG2815	serine threonine protein kinase
IRI77_RS14820	COG0515	serine threonine protein kinase
IRI77_RS14840	COG1482	cell wall glycoprotein biosynthetic process
IRI77_RS14845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IRI77_RS14845	COG0662	Cupin 2, conserved barrel domain protein
IRI77_RS14860	COG1063	alcohol dehydrogenase
IRI77_RS14865	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS14885	COG0154	amidase activity
IRI77_RS14895	COG1960	acyl-CoA dehydrogenase activity
IRI77_RS14905	COG0535	radical SAM domain protein
IRI77_RS14920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRI77_RS14925	COG1970	mechanosensitive ion channel activity
IRI77_RS14935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IRI77_RS14955	COG0577	efflux transmembrane transporter activity
IRI77_RS14955	COG1136	(ABC) transporter
IRI77_RS14960	COG0577	efflux transmembrane transporter activity
IRI77_RS14985	COG2261	transglycosylase associated protein
IRI77_RS15045	COG1017	nitric oxide dioxygenase activity
IRI77_RS15045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IRI77_RS15050	COG1136	(ABC) transporter
IRI77_RS15050	COG0577	efflux transmembrane transporter activity
IRI77_RS15075	COG1138	Cytochrome C-type biogenesis protein
IRI77_RS15095	COG4555	ABC transporter
IRI77_RS15105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRI77_RS15115	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS15120	COG2890	protein-(glutamine-N5) methyltransferase activity
IRI77_RS15140	COG0022	dehydrogenase e1 component
IRI77_RS15155	COG0583	DNA-binding transcription factor activity
IRI77_RS15175	COG2851	Citrate transporter
IRI77_RS15185	COG2272	Belongs to the type-B carboxylesterase lipase family
IRI77_RS15235	COG3041	Addiction module toxin RelE StbE family
IRI77_RS15265	COG1690	Belongs to the RtcB family
IRI77_RS15270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IRI77_RS15280	COG0640	Transcriptional regulator
IRI77_RS15335	COG4589	Belongs to the CDS family
IRI77_RS15350	COG2453	phosphatase
IRI77_RS15350	COG0671	phosphoesterase, PA-phosphatase related
IRI77_RS15360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRI77_RS15405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS15415	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IRI77_RS15420	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
IRI77_RS15495	COG0357	Ribosomal RNA small subunit methyltransferase G
IRI77_RS15525	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS15530	COG0673	inositol 2-dehydrogenase activity
IRI77_RS15550	COG0348	domain, Protein
IRI77_RS15560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IRI77_RS15560	COG0493	'glutamate synthase
IRI77_RS15580	COG3278	Belongs to the heme-copper respiratory oxidase family
IRI77_RS15615	COG3458	cephalosporin-C deacetylase activity
IRI77_RS15675	COG0577	efflux transmembrane transporter activity
IRI77_RS15715	COG1476	TRANSCRIPTIONal
IRI77_RS15735	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS15740	COG1940	carbohydrate kinase activity
IRI77_RS15765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS15780	COG4585	Histidine kinase
IRI77_RS15800	COG1595	DNA-templated transcription, initiation
IRI77_RS15805	COG2885	chlorophyll binding
IRI77_RS15810	COG2197	response regulator
IRI77_RS15815	COG0463	Glycosyl transferase, family 2
IRI77_RS15825	COG3769	mannosylglycerate metabolic process
IRI77_RS15845	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS15855	COG1620	l-lactate permease
IRI77_RS15870	COG1620	l-lactate permease
IRI77_RS15925	COG3328	transposase activity
IRI77_RS15950	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IRI77_RS15955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IRI77_RS16015	COG0588	phosphoglycerate mutase activity
IRI77_RS16045	COG1187	pseudouridine synthase activity
IRI77_RS16110	COG0577	efflux transmembrane transporter activity
IRI77_RS16110	COG1136	(ABC) transporter
IRI77_RS16140	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRI77_RS16150	COG2234	aminopeptidase activity
IRI77_RS16155	COG2267	carboxylic ester hydrolase activity
IRI77_RS16175	COG0667	Aldo Keto reductase
IRI77_RS16180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IRI77_RS16195	COG3540	Alkaline phosphatase
IRI77_RS16235	COG0330	HflC and HflK could
IRI77_RS16245	COG0673	inositol 2-dehydrogenase activity
IRI77_RS16260	COG0673	inositol 2-dehydrogenase activity
IRI77_RS16280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRI77_RS16290	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IRI77_RS16310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IRI77_RS16315	COG0347	Belongs to the P(II) protein family
IRI77_RS16320	COG0004	ammonium transporteR
IRI77_RS16325	COG0475	glutathione-regulated potassium exporter activity
IRI77_RS16340	COG4302	ethanolamine ammonia-lyase activity
IRI77_RS16345	COG4303	Ethanolamine ammonia lyase large subunit
IRI77_RS16350	COG0531	amino acid
IRI77_RS16465	COG0281	malic enzyme
IRI77_RS16465	COG0280	phosphate acetyltransferase
IRI77_RS16485	COG2076	Multidrug Resistance protein
IRI77_RS16495	COG2198	Histidine kinase
IRI77_RS16495	COG2205	protein histidine kinase activity
IRI77_RS16495	COG0784	Response regulator, receiver
IRI77_RS16515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRI77_RS16515	COG0617	tRNA 3'-terminal CCA addition
IRI77_RS16515	COG0517	IMP dehydrogenase activity
IRI77_RS16520	COG4974	Belongs to the 'phage' integrase family
IRI77_RS16550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS16555	COG0484	heat shock protein binding
IRI77_RS16560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRI77_RS16565	COG1132	(ABC) transporter
IRI77_RS16575	COG4774	siderophore transport
IRI77_RS16580	COG3128	pkhd-type hydroxylase
IRI77_RS16590	COG0484	heat shock protein binding
IRI77_RS16610	COG0535	radical SAM domain protein
IRI77_RS16615	COG0596	Alpha beta hydrolase
IRI77_RS16640	COG3119	arylsulfatase activity
IRI77_RS16690	COG4771	TonB-dependent receptor
IRI77_RS16700	COG5002	protein histidine kinase activity
IRI77_RS16700	COG2205	protein histidine kinase activity
IRI77_RS16700	COG0784	Response regulator, receiver
IRI77_RS16710	COG0800	Aldolase
IRI77_RS16750	COG1073	alpha beta
IRI77_RS16755	COG0673	inositol 2-dehydrogenase activity
IRI77_RS16795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IRI77_RS16805	COG0531	amino acid
IRI77_RS16820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IRI77_RS16830	COG0577	efflux transmembrane transporter activity
IRI77_RS16830	COG1136	(ABC) transporter
IRI77_RS16840	COG0613	PHP domain protein
IRI77_RS16845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IRI77_RS16855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS16875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRI77_RS16880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRI77_RS16895	COG2271	Major facilitator Superfamily
IRI77_RS16910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IRI77_RS16915	COG1921	L-seryl-tRNASec selenium transferase activity
IRI77_RS16925	COG0673	inositol 2-dehydrogenase activity
IRI77_RS16935	COG1609	Transcriptional regulator
IRI77_RS16950	COG0826	peptidase U32
IRI77_RS16970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRI77_RS16975	COG1959	2 iron, 2 sulfur cluster binding
IRI77_RS17000	COG0494	nUDIX hydrolase
IRI77_RS17005	COG0822	iron-sulfur transferase activity
IRI77_RS17015	COG0612	Peptidase, M16
IRI77_RS17040	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
IRI77_RS17050	COG0235	Class ii aldolase
IRI77_RS17060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS17065	COG0667	Aldo Keto reductase
IRI77_RS17075	COG0167	dihydroorotate dehydrogenase activity
IRI77_RS17090	COG1045	serine acetyltransferase
IRI77_RS17110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IRI77_RS17130	COG2205	protein histidine kinase activity
IRI77_RS17130	COG0784	Response regulator, receiver
IRI77_RS17130	COG5002	protein histidine kinase activity
IRI77_RS17135	COG0288	reversible hydration of carbon dioxide
IRI77_RS17160	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IRI77_RS17165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IRI77_RS17170	COG0052	Belongs to the universal ribosomal protein uS2 family
IRI77_RS17175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IRI77_RS17180	COG0528	UMP kinase activity
IRI77_RS17185	COG0233	cytoplasmic translational termination
IRI77_RS17190	COG2226	methyltransferase
IRI77_RS17195	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IRI77_RS17210	COG0776	regulation of translation
IRI77_RS17225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IRI77_RS17230	COG2001	Belongs to the MraZ family
IRI77_RS17235	COG0275	rRNA processing
IRI77_RS17250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IRI77_RS17255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRI77_RS17260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRI77_RS17265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IRI77_RS17270	COG0772	Belongs to the SEDS family
IRI77_RS17275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRI77_RS17280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IRI77_RS17285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IRI77_RS17290	COG0849	cell division
IRI77_RS17295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IRI77_RS17300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRI77_RS17320	COG0432	Pfam Uncharacterised protein family UPF0047
IRI77_RS17325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRI77_RS17330	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRI77_RS17345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRI77_RS17350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS17380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IRI77_RS17395	COG1666	GTP binding
IRI77_RS17400	COG0745	RESPONSE REGULATOR receiver
IRI77_RS17410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRI77_RS17415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRI77_RS17415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRI77_RS17420	COG0037	tRNA processing
IRI77_RS17430	COG0306	phosphate transporter
IRI77_RS17435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IRI77_RS17455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRI77_RS17485	COG0077	Prephenate dehydratase
IRI77_RS17485	COG1605	Chorismate mutase
IRI77_RS17490	COG0587	DNA-directed DNA polymerase activity
IRI77_RS17515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS17525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IRI77_RS17530	COG0217	transcriptional regulatory protein
IRI77_RS17615	COG0251	oxidation-reduction process
IRI77_RS17620	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS17635	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS17655	COG0142	geranyltranstransferase activity
IRI77_RS17660	COG0084	hydrolase, TatD family'
IRI77_RS17665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRI77_RS17665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRI77_RS17670	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IRI77_RS17675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IRI77_RS17680	COG1192	Involved in chromosome partitioning
IRI77_RS17695	COG1401	restriction endodeoxyribonuclease activity
IRI77_RS17705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IRI77_RS17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS17735	COG1538	Outer membrane efflux protein
IRI77_RS17745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRI77_RS17755	COG1136	(ABC) transporter
IRI77_RS17755	COG0577	efflux transmembrane transporter activity
IRI77_RS17775	COG2226	methyltransferase
IRI77_RS17785	COG2223	nitrite transmembrane transporter activity
IRI77_RS17795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRI77_RS17800	COG0243	molybdopterin cofactor binding
IRI77_RS17805	COG0437	4 iron, 4 sulfur cluster binding
IRI77_RS17810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRI77_RS17810	COG1648	precorrin-2 dehydrogenase activity
IRI77_RS17820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRI77_RS17820	COG1648	precorrin-2 dehydrogenase activity
IRI77_RS17825	COG0443	Heat shock 70 kDa protein
IRI77_RS17840	COG0300	oxidoreductase activity
IRI77_RS17870	COG3119	arylsulfatase activity
IRI77_RS17875	COG0640	Transcriptional regulator
IRI77_RS17890	COG1595	DNA-templated transcription, initiation
IRI77_RS17905	COG1063	alcohol dehydrogenase
IRI77_RS17910	COG1070	Carbohydrate kinase
IRI77_RS17925	COG0740	serine-type endopeptidase activity
IRI77_RS17945	COG0483	inositol monophosphate 1-phosphatase activity
IRI77_RS17950	COG1022	Amp-dependent synthetase and ligase
IRI77_RS17955	COG0473	3-isopropylmalate dehydrogenase activity
IRI77_RS17965	COG0577	efflux transmembrane transporter activity
IRI77_RS17965	COG1136	(ABC) transporter
IRI77_RS17970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IRI77_RS17975	COG1309	transcriptional regulator
IRI77_RS17985	COG1657	PFAM Prenyltransferase squalene oxidase
IRI77_RS18005	COG0577	efflux transmembrane transporter activity
IRI77_RS18005	COG1136	(ABC) transporter
IRI77_RS18045	COG3618	amidohydrolase
IRI77_RS18050	COG3064	Membrane
IRI77_RS18055	COG0072	phenylalanine-tRNA ligase activity
IRI77_RS18055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRI77_RS18080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IRI77_RS18100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRI77_RS18105	COG0540	Belongs to the ATCase OTCase family
IRI77_RS18110	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IRI77_RS18125	COG2226	methyltransferase
IRI77_RS18140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRI77_RS18150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRI77_RS18150	COG0646	methionine synthase
IRI77_RS18155	COG5012	cobalamin binding
IRI77_RS18180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IRI77_RS18205	COG1695	Transcriptional regulator
IRI77_RS18210	COG1136	(ABC) transporter
IRI77_RS18210	COG0577	efflux transmembrane transporter activity
IRI77_RS18215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRI77_RS18225	COG2949	membrane
IRI77_RS18235	COG1595	DNA-templated transcription, initiation
IRI77_RS18275	COG1136	(ABC) transporter
IRI77_RS18275	COG0577	efflux transmembrane transporter activity
IRI77_RS18295	COG2199	diguanylate cyclase activity
IRI77_RS18295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRI77_RS18315	COG0477	Major facilitator Superfamily
IRI77_RS18315	COG2814	Major facilitator Superfamily
IRI77_RS18340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRI77_RS18385	COG1136	(ABC) transporter
IRI77_RS18385	COG0577	efflux transmembrane transporter activity
IRI77_RS18390	COG0577	efflux transmembrane transporter activity
IRI77_RS18390	COG1136	(ABC) transporter
IRI77_RS18430	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS18440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRI77_RS18445	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRI77_RS18470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IRI77_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS18520	COG0430	RNA-3'-phosphate cyclase activity
IRI77_RS18525	COG1690	Belongs to the RtcB family
IRI77_RS18550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IRI77_RS18570	COG0698	ribose 5-phosphate isomerase
IRI77_RS18580	COG1956	GAF domain-containing protein
IRI77_RS18590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS18635	COG0277	FAD linked oxidase domain protein
IRI77_RS18655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS18660	COG1846	Transcriptional regulator
IRI77_RS18665	COG0586	Pfam SNARE associated Golgi protein
IRI77_RS18680	COG0308	aminopeptidase N
IRI77_RS18695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IRI77_RS18700	COG0577	efflux transmembrane transporter activity
IRI77_RS18720	COG1131	(ABC) transporter
IRI77_RS18775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IRI77_RS18785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IRI77_RS18805	COG1940	carbohydrate kinase activity
IRI77_RS18830	COG5000	phosphorelay sensor kinase activity
IRI77_RS18835	COG2204	response regulator
IRI77_RS18875	COG1090	epimerase
IRI77_RS18915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IRI77_RS18920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IRI77_RS18925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IRI77_RS18930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IRI77_RS18950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IRI77_RS18955	COG1228	amidohydrolase
IRI77_RS18980	COG4952	isomerase
IRI77_RS18995	COG1187	pseudouridine synthase activity
IRI77_RS19000	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IRI77_RS19005	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IRI77_RS19010	COG1657	PFAM Prenyltransferase squalene oxidase
IRI77_RS19035	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IRI77_RS19045	COG0799	negative regulation of ribosome biogenesis
IRI77_RS19075	COG1131	(ABC) transporter
IRI77_RS19080	COG3836	Belongs to the HpcH HpaI aldolase family
IRI77_RS19125	COG3678	ATP-independent chaperone mediated protein folding
IRI77_RS19135	COG1595	DNA-templated transcription, initiation
IRI77_RS19140	COG0730	response to heat
IRI77_RS19155	COG2197	response regulator
IRI77_RS19160	COG4585	Histidine kinase
IRI77_RS19180	COG1993	acr, cog1993
IRI77_RS19200	COG0175	sulfate reduction
IRI77_RS19210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IRI77_RS19240	COG3940	Belongs to the glycosyl hydrolase 43 family
IRI77_RS19245	COG0456	acetyltransferase
IRI77_RS19270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IRI77_RS19290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IRI77_RS19300	COG4941	Belongs to the sigma-70 factor family
IRI77_RS19305	COG3795	YCII-related domain
IRI77_RS19325	COG1615	UPF0182 protein
IRI77_RS19330	COG0745	RESPONSE REGULATOR receiver
IRI77_RS19355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IRI77_RS19360	COG0577	efflux transmembrane transporter activity
IRI77_RS19385	COG1136	(ABC) transporter
IRI77_RS19385	COG0577	efflux transmembrane transporter activity
IRI77_RS19390	COG1074	ATP-dependent DNA helicase activity
IRI77_RS19405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRI77_RS19415	COG2205	protein histidine kinase activity
IRI77_RS19450	COG0431	NADPH-dependent FMN reductase
IRI77_RS19455	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IRI77_RS19470	COG0667	Aldo Keto reductase
IRI77_RS19480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS19515	COG0148	phosphopyruvate hydratase activity
IRI77_RS19530	COG0280	phosphate acetyltransferase
IRI77_RS19535	COG0123	including yeast histone deacetylase and acetoin utilization protein
IRI77_RS19555	COG0109	protoheme IX farnesyltransferase activity
IRI77_RS19565	COG2322	membrane
IRI77_RS19620	COG1337	RAMP superfamily
IRI77_RS19635	COG3267	Type II secretory pathway component ExeA
IRI77_RS19635	COG3409	Peptidoglycan-binding domain 1 protein
IRI77_RS19655	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS19720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRI77_RS19725	COG2201	protein-glutamate methylesterase activity
IRI77_RS19730	COG0745	RESPONSE REGULATOR receiver
IRI77_RS19755	COG2198	Histidine kinase
IRI77_RS19755	COG0643	Histidine kinase
IRI77_RS19755	COG0784	Response regulator, receiver
IRI77_RS19770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRI77_RS19785	COG4464	protein tyrosine phosphatase activity
IRI77_RS19805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS19810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IRI77_RS19820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRI77_RS19835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS19845	COG0110	maltose O-acetyltransferase activity
IRI77_RS19855	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS19860	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS19900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IRI77_RS19930	COG0489	protein tyrosine kinase activity
IRI77_RS19955	COG5002	protein histidine kinase activity
IRI77_RS19970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS19980	COG2304	oxidoreductase activity
IRI77_RS19990	COG2815	serine threonine protein kinase
IRI77_RS19990	COG0515	serine threonine protein kinase
IRI77_RS20000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRI77_RS20005	COG4770	biotin carboxylase activity
IRI77_RS20020	COG1136	(ABC) transporter
IRI77_RS20020	COG0577	efflux transmembrane transporter activity
IRI77_RS20030	COG1937	Protein conserved in bacteria
IRI77_RS20065	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IRI77_RS20070	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS20105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRI77_RS20120	COG3275	phosphorelay sensor kinase activity
IRI77_RS20125	COG3279	Response regulator of the LytR AlgR family
IRI77_RS20135	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS20150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IRI77_RS20155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IRI77_RS20165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS20170	COG1696	Membrane protein involved in D-alanine export
IRI77_RS20185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRI77_RS20190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRI77_RS20205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IRI77_RS20245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRI77_RS20265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRI77_RS20280	COG2912	Transglutaminase-like superfamily
IRI77_RS20300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRI77_RS20340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRI77_RS20360	COG1414	Transcriptional regulator
IRI77_RS20365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IRI77_RS20370	COG0745	RESPONSE REGULATOR receiver
IRI77_RS20380	COG2201	protein-glutamate methylesterase activity
IRI77_RS20385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRI77_RS20390	COG0745	RESPONSE REGULATOR receiver
IRI77_RS20395	COG0835	chemotaxis
IRI77_RS20400	COG0840	transmembrane signaling receptor activity
IRI77_RS20415	COG2208	phosphoserine phosphatase activity
IRI77_RS20420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRI77_RS20440	COG0489	protein tyrosine kinase activity
IRI77_RS20445	COG2244	polysaccharide biosynthetic process
IRI77_RS20465	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS20470	COG0297	glycogen (starch) synthase activity
IRI77_RS20490	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IRI77_RS20505	COG2801	Transposase and inactivated derivatives
IRI77_RS20505	COG3415	Transposase
IRI77_RS20545	COG0069	glutamate synthase activity
IRI77_RS20545	COG0070	glutamate synthase
IRI77_RS20545	COG0067	glutamate synthase
IRI77_RS20550	COG0583	DNA-binding transcription factor activity
IRI77_RS20570	COG3119	arylsulfatase activity
IRI77_RS20595	COG2815	serine threonine protein kinase
IRI77_RS20595	COG0515	serine threonine protein kinase
IRI77_RS20610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRI77_RS20615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRI77_RS20620	COG0509	glycine decarboxylation via glycine cleavage system
IRI77_RS20625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IRI77_RS20635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IRI77_RS20640	COG0300	oxidoreductase activity
IRI77_RS20655	COG0577	efflux transmembrane transporter activity
IRI77_RS20655	COG1136	(ABC) transporter
IRI77_RS20675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IRI77_RS20680	COG3387	PFAM Glycoside hydrolase 15-related
IRI77_RS20685	COG1007	ATP synthesis coupled electron transport
IRI77_RS20700	COG0713	ATP synthesis coupled electron transport
IRI77_RS20710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IRI77_RS20725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IRI77_RS20730	COG0649	NAD binding
IRI77_RS20740	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS20755	COG0793	Belongs to the peptidase S41A family
IRI77_RS20765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IRI77_RS20775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IRI77_RS20785	COG1136	(ABC) transporter
IRI77_RS20785	COG0577	efflux transmembrane transporter activity
IRI77_RS20795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS20805	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IRI77_RS20810	COG0742	ribosomal rna small subunit methyltransferase
IRI77_RS20835	COG4249	Peptidase C14 caspase catalytic subunit p20
IRI77_RS20835	COG2319	Wd-40 repeat
IRI77_RS20840	COG0673	inositol 2-dehydrogenase activity
IRI77_RS20850	COG2815	serine threonine protein kinase
IRI77_RS20850	COG0515	serine threonine protein kinase
IRI77_RS20860	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IRI77_RS20870	COG0348	domain, Protein
IRI77_RS20875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IRI77_RS20880	COG1007	ATP synthesis coupled electron transport
IRI77_RS20890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IRI77_RS20895	COG0713	ATP synthesis coupled electron transport
IRI77_RS20905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS20910	COG0649	NAD binding
IRI77_RS20915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS20920	COG2010	Cytochrome c
IRI77_RS20925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IRI77_RS20940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRI77_RS20945	COG0321	lipoyl(octanoyl) transferase activity
IRI77_RS20950	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRI77_RS20960	COG1695	Transcriptional regulator
IRI77_RS20965	COG0577	efflux transmembrane transporter activity
IRI77_RS20965	COG1136	(ABC) transporter
IRI77_RS20995	COG3275	phosphorelay sensor kinase activity
IRI77_RS21000	COG3279	Response regulator of the LytR AlgR family
IRI77_RS21005	COG0109	protoheme IX farnesyltransferase activity
IRI77_RS21005	COG1612	heme a metabolic process
IRI77_RS21020	COG1053	succinate dehydrogenase
IRI77_RS21040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRI77_RS21050	COG0489	protein tyrosine kinase activity
IRI77_RS21060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IRI77_RS21065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IRI77_RS21075	COG1979	alcohol dehydrogenase
IRI77_RS21100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRI77_RS21105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IRI77_RS21110	COG0228	four-way junction DNA binding
IRI77_RS21115	COG1837	Belongs to the UPF0109 family
IRI77_RS21120	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IRI77_RS21125	COG0336	Belongs to the RNA methyltransferase TrmD family
IRI77_RS21130	COG0335	large ribosomal subunit rRNA binding
IRI77_RS21135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IRI77_RS21165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRI77_RS21170	COG3706	GGDEF domain
IRI77_RS21190	COG1404	Belongs to the peptidase S8 family
IRI77_RS21195	COG0673	inositol 2-dehydrogenase activity
IRI77_RS21200	COG0501	Belongs to the peptidase M48B family
IRI77_RS21230	COG2124	cytochrome p450
IRI77_RS21250	COG0724	RNA recognition motif
IRI77_RS21255	COG3386	PFAM SMP-30 Gluconolaconase
IRI77_RS21260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRI77_RS21280	COG1620	l-lactate permease
IRI77_RS21290	COG0248	Ppx GppA phosphatase
IRI77_RS21295	COG1473	amidohydrolase
IRI77_RS21335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IRI77_RS21340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IRI77_RS21345	COG4956	integral membrane protein (PIN domain superfamily)
IRI77_RS21355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRI77_RS21360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IRI77_RS21370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IRI77_RS21375	COG1297	OPT oligopeptide transporter protein
IRI77_RS21380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRI77_RS21455	COG0442	prolyl-tRNA aminoacylation
IRI77_RS21460	COG3710	Transcriptional regulator
IRI77_RS21480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRI77_RS21495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRI77_RS21505	COG0571	ribonuclease III activity
IRI77_RS21555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRI77_RS21570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS21580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRI77_RS21605	COG1695	Transcriptional regulator
IRI77_RS21630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IRI77_RS21645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRI77_RS21665	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS21700	COG0673	inositol 2-dehydrogenase activity
IRI77_RS21765	COG0626	cystathionine gamma-synthase activity
IRI77_RS21785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRI77_RS21800	COG1725	Transcriptional regulator
IRI77_RS21810	COG0330	HflC and HflK could
IRI77_RS21815	COG2239	Acts as a magnesium transporter
IRI77_RS21830	COG1446	asparaginase
IRI77_RS21840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IRI77_RS21880	COG1082	Xylose isomerase domain protein TIM barrel
IRI77_RS21890	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS21895	COG3534	alpha-L-arabinofuranosidase
IRI77_RS21905	COG2703	oxygen carrier activity
IRI77_RS21920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS21935	COG0577	efflux transmembrane transporter activity
IRI77_RS21935	COG1136	(ABC) transporter
IRI77_RS21975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRI77_RS21985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IRI77_RS22000	COG1253	flavin adenine dinucleotide binding
IRI77_RS22030	COG1012	belongs to the aldehyde dehydrogenase family
IRI77_RS22065	COG2271	Major facilitator Superfamily
IRI77_RS22070	COG1968	undecaprenyl-diphosphatase activity
IRI77_RS22075	COG0469	pyruvate kinase activity
IRI77_RS22080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS22080	COG2010	Cytochrome c
IRI77_RS22100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRI77_RS22100	COG2755	lipolytic protein G-D-S-L family
IRI77_RS22105	COG0673	inositol 2-dehydrogenase activity
IRI77_RS22110	COG0346	lactoylglutathione lyase activity
IRI77_RS22150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IRI77_RS22200	COG1725	Transcriptional regulator
IRI77_RS22205	COG1131	(ABC) transporter
IRI77_RS22215	COG3604	Transcriptional regulator
IRI77_RS22235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IRI77_RS22240	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IRI77_RS22255	COG0656	L-ascorbic acid biosynthetic process
IRI77_RS22285	COG0427	acetyl-CoA hydrolase
IRI77_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS22295	COG0183	Belongs to the thiolase family
IRI77_RS22300	COG2272	Belongs to the type-B carboxylesterase lipase family
IRI77_RS22310	COG1595	DNA-templated transcription, initiation
IRI77_RS22350	COG2197	response regulator
IRI77_RS22380	COG1082	Xylose isomerase domain protein TIM barrel
IRI77_RS22410	COG4941	Belongs to the sigma-70 factor family
IRI77_RS22420	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IRI77_RS22440	COG0481	GTPase activity
IRI77_RS22445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IRI77_RS22450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRI77_RS22495	COG0673	inositol 2-dehydrogenase activity
IRI77_RS22500	COG0673	inositol 2-dehydrogenase activity
IRI77_RS22525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS22535	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRI77_RS22545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IRI77_RS22550	COG0515	serine threonine protein kinase
IRI77_RS22600	COG0577	efflux transmembrane transporter activity
IRI77_RS22600	COG1136	(ABC) transporter
IRI77_RS22605	COG0577	efflux transmembrane transporter activity
IRI77_RS22605	COG1136	(ABC) transporter
IRI77_RS22635	COG1136	(ABC) transporter
IRI77_RS22635	COG0577	efflux transmembrane transporter activity
IRI77_RS22640	COG1695	Transcriptional regulator
IRI77_RS22645	COG0006	proline dipeptidase activity
IRI77_RS22655	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS22665	COG1472	Belongs to the glycosyl hydrolase 3 family
IRI77_RS22670	COG2211	Major facilitator Superfamily
IRI77_RS22685	COG1764	response to oxidative stress
IRI77_RS22690	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS22695	COG4191	Histidine kinase
IRI77_RS22700	COG4566	intracellular signal transduction
IRI77_RS22705	COG4566	intracellular signal transduction
IRI77_RS22730	COG0457	Tetratricopeptide repeat
IRI77_RS22750	COG0531	amino acid
IRI77_RS22755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS22775	COG3619	membrane
IRI77_RS22790	COG2070	2-Nitropropane dioxygenase
IRI77_RS22795	COG0745	RESPONSE REGULATOR receiver
IRI77_RS22815	COG0784	Response regulator, receiver
IRI77_RS22815	COG0643	Histidine kinase
IRI77_RS22815	COG2198	Histidine kinase
IRI77_RS22820	COG0840	transmembrane signaling receptor activity
IRI77_RS22825	COG0835	chemotaxis
IRI77_RS22830	COG0745	RESPONSE REGULATOR receiver
IRI77_RS22870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IRI77_RS22875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRI77_RS22880	COG4555	ABC transporter
IRI77_RS22920	COG2226	methyltransferase
IRI77_RS22925	COG0405	Gamma-glutamyltransferase
IRI77_RS22935	COG0017	Asparaginyl-tRNA synthetase
IRI77_RS22940	COG0010	Belongs to the arginase family
IRI77_RS22945	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRI77_RS22950	COG0793	Belongs to the peptidase S41A family
IRI77_RS22975	COG0515	serine threonine protein kinase
IRI77_RS23010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRI77_RS23035	COG1012	belongs to the aldehyde dehydrogenase family
IRI77_RS23105	COG1830	Aldolase
IRI77_RS23130	COG1205	dead DEAH box helicase
IRI77_RS23130	COG1111	helicase
IRI77_RS23140	COG4974	Belongs to the 'phage' integrase family
IRI77_RS23145	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IRI77_RS23155	COG1760	l-serine dehydratase
IRI77_RS23160	COG0586	Pfam SNARE associated Golgi protein
IRI77_RS23165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRI77_RS23175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IRI77_RS23190	COG0641	radical SAM
IRI77_RS23205	COG0673	inositol 2-dehydrogenase activity
IRI77_RS23215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRI77_RS23230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS23265	COG4191	Histidine kinase
IRI77_RS23270	COG2204	response regulator
IRI77_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS23300	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS23315	COG1609	Transcriptional regulator
IRI77_RS23345	COG1295	ribonuclease BN
IRI77_RS23390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IRI77_RS23395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IRI77_RS23400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IRI77_RS23405	COG0402	S-adenosylhomocysteine deaminase activity
IRI77_RS23410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRI77_RS23415	COG2801	Transposase and inactivated derivatives
IRI77_RS23415	COG3415	Transposase
IRI77_RS23430	COG1490	D-aminoacyl-tRNA deacylase activity
IRI77_RS23435	COG1122	ATPase activity
IRI77_RS23445	COG0310	cobalt ion transport
IRI77_RS23450	COG0788	formyltetrahydrofolate deformylase activity
IRI77_RS23460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRI77_RS23465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IRI77_RS23470	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IRI77_RS23480	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRI77_RS23485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IRI77_RS23500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IRI77_RS23510	COG0577	efflux transmembrane transporter activity
IRI77_RS23510	COG1136	(ABC) transporter
IRI77_RS23520	COG0577	efflux transmembrane transporter activity
IRI77_RS23520	COG1136	(ABC) transporter
IRI77_RS23540	COG0736	holo-[acyl-carrier-protein] synthase activity
IRI77_RS23550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IRI77_RS23555	COG1404	Belongs to the peptidase S8 family
IRI77_RS23565	COG3275	phosphorelay sensor kinase activity
IRI77_RS23595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IRI77_RS23600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IRI77_RS23605	COG2226	methyltransferase
IRI77_RS23615	COG3275	phosphorelay sensor kinase activity
IRI77_RS23620	COG0009	L-threonylcarbamoyladenylate synthase
IRI77_RS23625	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IRI77_RS23630	COG0791	NLP P60 protein
IRI77_RS23650	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRI77_RS23650	COG0567	Dehydrogenase, E1 component
IRI77_RS23655	COG2096	Adenosyltransferase
IRI77_RS23660	COG0488	(ABC) transporter
IRI77_RS23665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS23665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS23670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRI77_RS23680	COG0251	oxidation-reduction process
IRI77_RS23690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRI77_RS23690	COG2169	Transcriptional regulator
IRI77_RS23700	COG3548	integral membrane protein
IRI77_RS23705	COG0673	inositol 2-dehydrogenase activity
IRI77_RS23730	COG0825	malonyl-CoA metabolic process
IRI77_RS23745	COG0151	Belongs to the GarS family
IRI77_RS23750	COG0445	tRNA wobble uridine modification
IRI77_RS23760	COG1475	DNA binding
IRI77_RS23775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IRI77_RS23795	COG1216	Glycosyl transferase, family 2
IRI77_RS23805	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS23815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IRI77_RS23820	COG4999	Histidine kinase
IRI77_RS23820	COG3850	Histidine kinase
IRI77_RS23820	COG2205	protein histidine kinase activity
IRI77_RS23820	COG3437	response regulator, receiver
IRI77_RS23830	COG0592	DNA-directed DNA polymerase activity
IRI77_RS23880	COG1022	Amp-dependent synthetase and ligase
IRI77_RS23890	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS23950	COG3710	Transcriptional regulator
IRI77_RS23975	COG3710	Transcriptional regulator
IRI77_RS23995	COG2815	serine threonine protein kinase
IRI77_RS23995	COG0515	serine threonine protein kinase
IRI77_RS24000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRI77_RS24080	COG3781	membrane
IRI77_RS24100	COG2815	serine threonine protein kinase
IRI77_RS24100	COG0515	serine threonine protein kinase
IRI77_RS24110	COG0515	serine threonine protein kinase
IRI77_RS24145	COG3059	membrane
IRI77_RS24150	COG3604	Transcriptional regulator
IRI77_RS24155	COG4191	Histidine kinase
IRI77_RS24160	COG4566	intracellular signal transduction
IRI77_RS24165	COG0835	chemotaxis
IRI77_RS24165	COG0784	Response regulator, receiver
IRI77_RS24170	COG0515	serine threonine protein kinase
IRI77_RS24170	COG2815	serine threonine protein kinase
IRI77_RS24175	COG4566	intracellular signal transduction
IRI77_RS24190	COG3391	amine dehydrogenase activity
IRI77_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS24230	COG2321	neutral zinc metallopeptidase
IRI77_RS24270	COG2813	Specifically methylates the guanine in position
IRI77_RS24280	COG1960	acyl-CoA dehydrogenase activity
IRI77_RS24300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRI77_RS24305	COG0386	Belongs to the glutathione peroxidase family
IRI77_RS24310	COG1024	Enoyl-CoA hydratase
IRI77_RS24315	COG0750	zinc metalloprotease
IRI77_RS24320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IRI77_RS24330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRI77_RS24345	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS24365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRI77_RS24375	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS24400	COG0346	lactoylglutathione lyase activity
IRI77_RS24435	COG1309	transcriptional regulator
IRI77_RS24440	COG1294	oxidase, subunit
IRI77_RS24445	COG1271	oxidase subunit
IRI77_RS24455	COG0564	pseudouridine synthase activity
IRI77_RS24460	COG0616	signal peptide processing
IRI77_RS24465	COG3415	Transposase
IRI77_RS24465	COG2801	Transposase and inactivated derivatives
IRI77_RS24480	COG0515	serine threonine protein kinase
IRI77_RS24480	COG2815	serine threonine protein kinase
IRI77_RS24510	COG0779	Required for maturation of 30S ribosomal subunits
IRI77_RS24515	COG0195	Participates in both transcription termination and antitermination
IRI77_RS24520	COG3266	domain, Protein
IRI77_RS24520	COG3266	domain, Protein
IRI77_RS24520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IRI77_RS24520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IRI77_RS24540	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IRI77_RS24550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRI77_RS24555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IRI77_RS24570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRI77_RS24580	COG4591	ABC-type transport system involved in lipoprotein release permease component
IRI77_RS24580	COG1136	(ABC) transporter
IRI77_RS24590	COG1136	(ABC) transporter
IRI77_RS24605	COG2197	response regulator
IRI77_RS24615	COG0616	signal peptide processing
IRI77_RS24620	COG1191	sigma factor activity
IRI77_RS24635	COG3494	Protein of unknown function (DUF1009)
IRI77_RS24645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IRI77_RS24650	COG1473	amidohydrolase
IRI77_RS24655	COG0688	phosphatidylethanolamine metabolic process
IRI77_RS24660	COG1183	phosphatidylcholine synthase activity
IRI77_RS24705	COG4585	Histidine kinase
IRI77_RS24710	COG0339	signal peptide processing
IRI77_RS24725	COG2197	response regulator
IRI77_RS24730	COG4585	Histidine kinase
IRI77_RS24740	COG1131	(ABC) transporter
IRI77_RS24765	COG2197	response regulator
IRI77_RS24775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IRI77_RS24785	COG5002	protein histidine kinase activity
IRI77_RS24790	COG1132	(ABC) transporter
IRI77_RS24810	COG2871	sodium ion transport
IRI77_RS24820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRI77_RS24840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRI77_RS24860	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IRI77_RS24885	COG1272	protein, Hemolysin III
IRI77_RS24890	COG0534	Mate efflux family protein
IRI77_RS24895	COG1136	(ABC) transporter
IRI77_RS24895	COG0577	efflux transmembrane transporter activity
IRI77_RS24900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRI77_RS24900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IRI77_RS24950	COG0297	glycogen (starch) synthase activity
IRI77_RS24955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRI77_RS24955	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS24960	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS24965	COG0463	Glycosyl transferase, family 2
IRI77_RS24985	COG1846	Transcriptional regulator
IRI77_RS24985	COG0456	acetyltransferase
IRI77_RS25020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRI77_RS25030	COG2986	histidine ammonia-lyase
IRI77_RS25040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IRI77_RS25065	COG3253	May function as heme-dependent peroxidase
IRI77_RS25075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRI77_RS25080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRI77_RS25085	COG0659	secondary active sulfate transmembrane transporter activity
IRI77_RS25090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IRI77_RS25110	COG1136	(ABC) transporter
IRI77_RS25110	COG0577	efflux transmembrane transporter activity
IRI77_RS25115	COG1136	(ABC) transporter
IRI77_RS25115	COG0577	efflux transmembrane transporter activity
IRI77_RS25130	COG0459	protein refolding
IRI77_RS25135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRI77_RS25150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IRI77_RS25160	COG1660	Displays ATPase and GTPase activities
IRI77_RS25170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IRI77_RS25175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRI77_RS25210	COG0673	inositol 2-dehydrogenase activity
IRI77_RS25215	COG0673	inositol 2-dehydrogenase activity
IRI77_RS25220	COG1217	gtp-binding protein TYPA
IRI77_RS25225	COG1160	GTP binding
IRI77_RS25250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IRI77_RS25255	COG2204	response regulator
IRI77_RS25285	COG0789	Transcriptional regulator
IRI77_RS25290	COG0484	heat shock protein binding
IRI77_RS25295	COG0443	Heat shock 70 kDa protein
IRI77_RS25325	COG0577	efflux transmembrane transporter activity
IRI77_RS25325	COG1136	(ABC) transporter
IRI77_RS25340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRI77_RS25350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRI77_RS25380	COG1595	DNA-templated transcription, initiation
IRI77_RS25385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRI77_RS25415	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS25425	COG0463	Glycosyl transferase, family 2
IRI77_RS25430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS25430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IRI77_RS25455	COG2032	superoxide dismutase activity
IRI77_RS25460	COG0583	DNA-binding transcription factor activity
IRI77_RS25485	COG0673	inositol 2-dehydrogenase activity
IRI77_RS25560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IRI77_RS25585	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IRI77_RS25590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IRI77_RS25610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRI77_RS25615	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IRI77_RS25625	COG3119	arylsulfatase activity
IRI77_RS25670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IRI77_RS25675	COG1166	arginine decarboxylase activity
IRI77_RS25700	COG3191	aminopeptidase activity
IRI77_RS25705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IRI77_RS25735	COG3250	beta-galactosidase activity
IRI77_RS25750	COG1705	Flagellar rod assembly protein muramidase FlgJ
IRI77_RS25750	COG1388	LysM domain
IRI77_RS25755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IRI77_RS25760	COG1199	ATP-dependent helicase activity
IRI77_RS25765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IRI77_RS25770	COG1847	R3H domain protein
IRI77_RS25780	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IRI77_RS25785	COG0594	ribonuclease P activity
IRI77_RS25790	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IRI77_RS25800	COG0668	transmembrane transport
IRI77_RS25825	COG2819	hydrolase of the alpha beta superfamily
IRI77_RS25830	COG0584	glycerophosphoryl diester phosphodiesterase
IRI77_RS25835	COG4946	Tricorn protease homolog
IRI77_RS25835	COG0793	Belongs to the peptidase S41A family
IRI77_RS25850	COG0129	dihydroxy-acid dehydratase activity
IRI77_RS25870	COG3118	belongs to the thioredoxin family
IRI77_RS25875	COG0297	glycogen (starch) synthase activity
IRI77_RS25885	COG0513	Belongs to the DEAD box helicase family
IRI77_RS25890	COG2205	protein histidine kinase activity
IRI77_RS25895	COG0745	RESPONSE REGULATOR receiver
IRI77_RS25950	COG2814	Major facilitator Superfamily
IRI77_RS25960	COG2271	Major facilitator Superfamily
IRI77_RS25965	COG0268	Binds directly to 16S ribosomal RNA
IRI77_RS25995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS25995	COG2010	Cytochrome c
IRI77_RS26000	COG2080	2 iron, 2 sulfur cluster binding
IRI77_RS26010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS26015	COG0577	efflux transmembrane transporter activity
IRI77_RS26015	COG1136	(ABC) transporter
IRI77_RS26020	COG1959	2 iron, 2 sulfur cluster binding
IRI77_RS26045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRI77_RS26065	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS26070	COG3394	polysaccharide catabolic process
IRI77_RS26085	COG0489	protein tyrosine kinase activity
IRI77_RS26125	COG0011	TIGRFAM Protein of
IRI77_RS26130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IRI77_RS26135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IRI77_RS26140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IRI77_RS26145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IRI77_RS26150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRI77_RS26155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IRI77_RS26170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IRI77_RS26175	COG0049	tRNA binding
IRI77_RS26180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IRI77_RS26185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IRI77_RS26190	COG0051	transcription antitermination factor activity, RNA binding
IRI77_RS26195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IRI77_RS26200	COG0088	Forms part of the polypeptide exit tunnel
IRI77_RS26205	COG0089	rRNA binding
IRI77_RS26210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IRI77_RS26215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IRI77_RS26220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IRI77_RS26225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IRI77_RS26230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IRI77_RS26235	COG0255	Belongs to the universal ribosomal protein uL29 family
IRI77_RS26240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IRI77_RS26245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IRI77_RS26250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IRI77_RS26255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IRI77_RS26260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRI77_RS26265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IRI77_RS26270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IRI77_RS26275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IRI77_RS26280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IRI77_RS26285	COG1841	ribosomal large subunit assembly
IRI77_RS26290	COG0200	Binds to the 23S rRNA
IRI77_RS26295	COG0201	protein transport
IRI77_RS26300	COG0563	adenylate kinase activity
IRI77_RS26305	COG0024	Methionine aminopeptidase
IRI77_RS26310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRI77_RS26315	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IRI77_RS26320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IRI77_RS26325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IRI77_RS26330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IRI77_RS26335	COG0202	RNA polymerase activity
IRI77_RS26340	COG0203	ribosomal protein L17
IRI77_RS26345	COG0071	Belongs to the small heat shock protein (HSP20) family
IRI77_RS26365	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRI77_RS26430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRI77_RS26435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS26450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRI77_RS26475	COG0535	radical SAM domain protein
IRI77_RS26495	COG2252	PERMEase
IRI77_RS26510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRI77_RS26515	COG1573	uracil-dna glycosylase
IRI77_RS26525	COG0308	aminopeptidase N
IRI77_RS26570	COG1704	LemA family
IRI77_RS26585	COG0612	Peptidase, M16
IRI77_RS26590	COG1472	Belongs to the glycosyl hydrolase 3 family
IRI77_RS26600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IRI77_RS26620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IRI77_RS26640	COG4191	Histidine kinase
IRI77_RS26645	COG2204	response regulator
IRI77_RS26685	COG1013	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS26685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IRI77_RS26685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IRI77_RS26685	COG0674	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS26695	COG0175	sulfate reduction
IRI77_RS26700	COG2895	sulfate adenylyltransferase (ATP) activity
IRI77_RS26710	COG0730	response to heat
IRI77_RS26715	COG1136	(ABC) transporter
IRI77_RS26720	COG0577	efflux transmembrane transporter activity
IRI77_RS26740	COG0288	reversible hydration of carbon dioxide
IRI77_RS26755	COG1193	negative regulation of DNA recombination
IRI77_RS26760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRI77_RS26800	COG1136	(ABC) transporter
IRI77_RS26800	COG0577	efflux transmembrane transporter activity
IRI77_RS26805	COG0673	inositol 2-dehydrogenase activity
IRI77_RS26810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRI77_RS26815	COG0805	protein transport
IRI77_RS26820	COG1802	Transcriptional regulator
IRI77_RS26835	COG0756	dUTP diphosphatase activity
IRI77_RS26850	COG2304	oxidoreductase activity
IRI77_RS26905	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS26925	COG0477	Major facilitator Superfamily
IRI77_RS26950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS26955	COG3604	Transcriptional regulator
IRI77_RS26965	COG2918	glutathione biosynthetic process
IRI77_RS26965	COG0189	ligase activity
IRI77_RS26970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IRI77_RS26970	COG0189	ligase activity
IRI77_RS26975	COG1132	(ABC) transporter
IRI77_RS27000	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IRI77_RS27015	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IRI77_RS27025	COG3764	Sortase (surface protein transpeptidase)
IRI77_RS27040	COG0281	malic enzyme
IRI77_RS27060	COG3604	Transcriptional regulator
IRI77_RS27070	COG3237	CsbD-like
IRI77_RS27080	COG2885	chlorophyll binding
IRI77_RS27085	COG0330	HflC and HflK could
IRI77_RS27105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRI77_RS27110	COG0459	protein refolding
IRI77_RS27130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS27150	COG2124	cytochrome p450
IRI77_RS27160	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS27205	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS27215	COG0561	phosphatase activity
IRI77_RS27230	COG0667	Aldo Keto reductase
IRI77_RS27245	COG2382	esterase
IRI77_RS27245	COG3693	PFAM glycoside hydrolase, family 10
IRI77_RS27285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRI77_RS27290	COG0517	IMP dehydrogenase activity
IRI77_RS27295	COG1013	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS27300	COG0674	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS27300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IRI77_RS27305	COG0436	Aminotransferase
IRI77_RS27310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IRI77_RS27315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRI77_RS27320	COG0047	phosphoribosylformylglycinamidine synthase activity
IRI77_RS27335	COG0259	pyridoxamine-phosphate oxidase activity
IRI77_RS27345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IRI77_RS27350	COG1459	type II secretion system
IRI77_RS27355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IRI77_RS27395	COG2204	response regulator
IRI77_RS27410	COG2205	protein histidine kinase activity
IRI77_RS27410	COG4999	Histidine kinase
IRI77_RS27410	COG3437	response regulator, receiver
IRI77_RS27410	COG3850	Histidine kinase
IRI77_RS27425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRI77_RS27435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IRI77_RS27435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IRI77_RS27455	COG0351	phosphomethylpyrimidine kinase
IRI77_RS27460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IRI77_RS27470	COG0577	efflux transmembrane transporter activity
IRI77_RS27475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRI77_RS27485	COG1695	Transcriptional regulator
IRI77_RS27515	COG0285	dihydrofolate synthase activity
IRI77_RS27545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IRI77_RS27560	COG4970	Tfp pilus assembly protein FimT
IRI77_RS27625	COG3408	Glycogen debranching enzyme
IRI77_RS27680	COG1131	(ABC) transporter
IRI77_RS27685	COG1131	(ABC) transporter
IRI77_RS27690	COG0842	Transport permease protein
IRI77_RS27695	COG0842	Transport permease protein
IRI77_RS27705	COG2234	aminopeptidase activity
IRI77_RS27710	COG0475	glutathione-regulated potassium exporter activity
IRI77_RS27725	COG2022	thiamine diphosphate biosynthetic process
IRI77_RS27775	COG2197	response regulator
IRI77_RS27820	COG0596	Alpha beta hydrolase
IRI77_RS27830	COG1764	response to oxidative stress
IRI77_RS27850	COG5520	Belongs to the glycosyl hydrolase 30 family
IRI77_RS27930	COG4774	siderophore transport
IRI77_RS27940	COG1695	Transcriptional regulator
IRI77_RS27945	COG1136	(ABC) transporter
IRI77_RS27945	COG0577	efflux transmembrane transporter activity
IRI77_RS27950	COG0318	PFAM AMP-dependent synthetase and ligase
IRI77_RS27955	COG1678	Uncharacterized ACR, COG1678
IRI77_RS27965	COG0768	penicillin binding
IRI77_RS27980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IRI77_RS27985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IRI77_RS27990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IRI77_RS28010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IRI77_RS28015	COG0504	CTP synthase activity
IRI77_RS28020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IRI77_RS28045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IRI77_RS28075	COG2267	carboxylic ester hydrolase activity
IRI77_RS28095	COG0783	Belongs to the Dps family
IRI77_RS28100	COG2267	carboxylic ester hydrolase activity
IRI77_RS28105	COG0557	exoribonuclease II activity
IRI77_RS28145	COG1858	cytochrome C peroxidase
IRI77_RS28155	COG3391	amine dehydrogenase activity
IRI77_RS28235	COG4555	ABC transporter
IRI77_RS28270	COG3132	Protein of unknown function, DUF480
IRI77_RS28275	COG0488	(ABC) transporter
IRI77_RS28280	COG1040	competence protein
IRI77_RS28290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IRI77_RS28295	COG3119	arylsulfatase activity
IRI77_RS28305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS28310	COG0673	inositol 2-dehydrogenase activity
IRI77_RS28320	COG0384	phenazine biosynthesis protein PhzF
IRI77_RS28355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IRI77_RS28405	COG0583	DNA-binding transcription factor activity
IRI77_RS28425	COG1136	(ABC) transporter
IRI77_RS28440	COG1136	(ABC) transporter
IRI77_RS28440	COG0577	efflux transmembrane transporter activity
IRI77_RS28455	COG1136	(ABC) transporter
IRI77_RS28455	COG0577	efflux transmembrane transporter activity
IRI77_RS28460	COG0252	asparaginase activity
IRI77_RS28470	COG0076	glutamate decarboxylase activity
IRI77_RS28535	COG0004	ammonium transporteR
IRI77_RS28540	COG0475	glutathione-regulated potassium exporter activity
IRI77_RS28550	COG3795	YCII-related domain
IRI77_RS28580	COG0667	Aldo Keto reductase
IRI77_RS28590	COG1136	(ABC) transporter
IRI77_RS28590	COG0577	efflux transmembrane transporter activity
IRI77_RS28605	COG0745	RESPONSE REGULATOR receiver
IRI77_RS28645	COG3546	catalase activity
IRI77_RS28650	COG3685	Protein conserved in bacteria
IRI77_RS28665	COG0835	chemotaxis
IRI77_RS28670	COG2201	protein-glutamate methylesterase activity
IRI77_RS28680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRI77_RS28685	COG0745	RESPONSE REGULATOR receiver
IRI77_RS28695	COG0745	RESPONSE REGULATOR receiver
IRI77_RS28700	COG0643	Histidine kinase
IRI77_RS28700	COG0784	Response regulator, receiver
IRI77_RS28700	COG2198	Histidine kinase
IRI77_RS28710	COG1136	(ABC) transporter
IRI77_RS28710	COG0577	efflux transmembrane transporter activity
IRI77_RS28730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IRI77_RS28745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRI77_RS28770	COG1426	Protein conserved in bacteria
IRI77_RS28790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRI77_RS28815	COG1012	belongs to the aldehyde dehydrogenase family
IRI77_RS28825	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS28830	COG2226	methyltransferase
IRI77_RS28890	COG2808	Putative FMN-binding domain
IRI77_RS28925	COG0698	ribose 5-phosphate isomerase
IRI77_RS28945	COG2814	Major facilitator Superfamily
IRI77_RS28955	COG3012	SEC-C Motif Domain Protein
IRI77_RS28990	COG3795	YCII-related domain
IRI77_RS29055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRI77_RS29065	COG4804	nuclease activity
IRI77_RS29080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IRI77_RS29085	COG2258	MOSC domain
IRI77_RS29090	COG0174	glutamine synthetase
IRI77_RS29095	COG0174	glutamine synthetase
IRI77_RS29115	COG2205	protein histidine kinase activity
IRI77_RS29120	COG3781	membrane
IRI77_RS29140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRI77_RS29145	COG1802	Transcriptional regulator
IRI77_RS29150	COG2271	Major facilitator Superfamily
IRI77_RS29170	COG0798	PFAM Bile acid sodium symporter
IRI77_RS29175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRI77_RS29195	COG1131	(ABC) transporter
IRI77_RS29215	COG2815	serine threonine protein kinase
IRI77_RS29215	COG0515	serine threonine protein kinase
IRI77_RS29245	COG1570	exodeoxyribonuclease VII activity
IRI77_RS29265	COG1902	pentaerythritol trinitrate reductase activity
IRI77_RS29275	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS29305	COG0517	IMP dehydrogenase activity
IRI77_RS29305	COG0516	GMP reductase activity
IRI77_RS29370	COG2814	Major facilitator Superfamily
IRI77_RS29370	COG0477	Major facilitator Superfamily
IRI77_RS29400	COG0322	excinuclease ABC activity
IRI77_RS29415	COG2226	methyltransferase
IRI77_RS29460	COG0750	zinc metalloprotease
IRI77_RS29535	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IRI77_RS29555	COG1393	Belongs to the ArsC family
IRI77_RS29565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRI77_RS29565	COG5322	oxidoreductase activity
IRI77_RS29605	COG0714	Associated with various cellular activities
IRI77_RS29620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IRI77_RS29625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IRI77_RS29630	COG1506	peptidase
IRI77_RS29630	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS29635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IRI77_RS29640	COG0124	histidyl-tRNA synthetase
IRI77_RS29690	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS29730	COG5002	protein histidine kinase activity
IRI77_RS29750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IRI77_RS29760	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IRI77_RS29770	COG2205	protein histidine kinase activity
IRI77_RS29775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRI77_RS29790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IRI77_RS29795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IRI77_RS29815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRI77_RS29870	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IRI77_RS29885	COG2205	protein histidine kinase activity
IRI77_RS29885	COG0784	Response regulator, receiver
IRI77_RS29885	COG2198	Histidine kinase
IRI77_RS29890	COG2855	membrane
IRI77_RS29895	COG3279	Response regulator of the LytR AlgR family
IRI77_RS29900	COG2972	Histidine kinase
IRI77_RS29910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IRI77_RS29915	COG0443	Heat shock 70 kDa protein
IRI77_RS29920	COG0443	Heat shock 70 kDa protein
IRI77_RS29960	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS29965	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS29985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IRI77_RS30010	COG0542	response to heat
IRI77_RS30015	COG1136	(ABC) transporter
IRI77_RS30020	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRI77_RS30025	COG1129	ABC transporter
IRI77_RS30035	COG0305	Participates in initiation and elongation during chromosome replication
IRI77_RS30060	COG1309	transcriptional regulator
IRI77_RS30085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRI77_RS30100	COG2706	6-phosphogluconolactonase activity
IRI77_RS30105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IRI77_RS30110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRI77_RS30140	COG1522	sequence-specific DNA binding
IRI77_RS30185	COG0488	(ABC) transporter
IRI77_RS30190	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IRI77_RS30195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IRI77_RS30200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IRI77_RS30205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRI77_RS30255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
IRI77_RS30260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS30290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IRI77_RS30295	COG0784	Response regulator, receiver
IRI77_RS30295	COG5002	protein histidine kinase activity
IRI77_RS30310	COG2986	histidine ammonia-lyase
IRI77_RS30315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRI77_RS30320	COG0405	Gamma-glutamyltransferase
IRI77_RS30330	COG3119	arylsulfatase activity
IRI77_RS30340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS30350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRI77_RS30360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IRI77_RS30365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS30395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRI77_RS30400	COG2201	protein-glutamate methylesterase activity
IRI77_RS30405	COG0745	RESPONSE REGULATOR receiver
IRI77_RS30420	COG0784	Response regulator, receiver
IRI77_RS30420	COG2198	Histidine kinase
IRI77_RS30420	COG0643	Histidine kinase
IRI77_RS30430	COG2382	esterase
IRI77_RS30440	COG0318	PFAM AMP-dependent synthetase and ligase
IRI77_RS30470	COG0673	inositol 2-dehydrogenase activity
IRI77_RS30475	COG0673	inositol 2-dehydrogenase activity
IRI77_RS30485	COG0347	Belongs to the P(II) protein family
IRI77_RS30505	COG1404	Belongs to the peptidase S8 family
IRI77_RS30515	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRI77_RS30540	COG2264	protein methyltransferase activity
IRI77_RS30575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRI77_RS30580	COG1064	alcohol dehydrogenase
IRI77_RS30590	COG0640	Transcriptional regulator
IRI77_RS30600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRI77_RS30605	COG0667	Aldo Keto reductase
IRI77_RS30610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IRI77_RS30615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IRI77_RS30620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IRI77_RS30625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IRI77_RS30645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS30650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IRI77_RS30655	COG0543	2 iron, 2 sulfur cluster binding
IRI77_RS30655	COG0493	'glutamate synthase
IRI77_RS30665	COG3119	arylsulfatase activity
IRI77_RS30670	COG0577	efflux transmembrane transporter activity
IRI77_RS30670	COG1136	(ABC) transporter
IRI77_RS30680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRI77_RS30680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRI77_RS30695	COG2193	ferroxidase activity
IRI77_RS30715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IRI77_RS30740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRI77_RS30765	COG1136	(ABC) transporter
IRI77_RS30765	COG0577	efflux transmembrane transporter activity
IRI77_RS30790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRI77_RS30800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRI77_RS30840	COG2133	pyrroloquinoline quinone binding
IRI77_RS30860	COG0129	dihydroxy-acid dehydratase activity
IRI77_RS30875	COG2815	serine threonine protein kinase
IRI77_RS30875	COG0515	serine threonine protein kinase
IRI77_RS30880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IRI77_RS30895	COG1408	metallophosphoesterase
IRI77_RS30905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IRI77_RS30910	COG0632	four-way junction helicase activity
IRI77_RS30915	COG2255	four-way junction helicase activity
IRI77_RS30930	COG2326	polyphosphate kinase activity
IRI77_RS30960	COG0741	lytic transglycosylase activity
IRI77_RS30975	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IRI77_RS30990	COG4946	Tricorn protease homolog
IRI77_RS30990	COG0793	Belongs to the peptidase S41A family
IRI77_RS31005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS31025	COG0577	efflux transmembrane transporter activity
IRI77_RS31025	COG1136	(ABC) transporter
IRI77_RS31035	COG0243	molybdopterin cofactor binding
IRI77_RS31055	COG1496	oxidoreductase activity
IRI77_RS31060	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRI77_RS31065	COG1595	DNA-templated transcription, initiation
IRI77_RS31110	COG2271	Major facilitator Superfamily
IRI77_RS31160	COG1309	transcriptional regulator
IRI77_RS31185	COG2318	DinB family
IRI77_RS31190	COG1846	Transcriptional regulator
IRI77_RS31210	COG5000	phosphorelay sensor kinase activity
IRI77_RS31230	COG1376	ErfK ybiS ycfS ynhG family protein
IRI77_RS31275	COG1136	(ABC) transporter
IRI77_RS31275	COG0577	efflux transmembrane transporter activity
IRI77_RS31285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IRI77_RS31305	COG2208	phosphoserine phosphatase activity
IRI77_RS31305	COG2770	Histidine kinase
IRI77_RS31335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IRI77_RS31345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRI77_RS31350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRI77_RS31355	COG2192	nodulation
IRI77_RS31360	COG0681	Belongs to the peptidase S26 family
IRI77_RS31375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IRI77_RS31380	COG1136	(ABC) transporter
IRI77_RS31380	COG0577	efflux transmembrane transporter activity
IRI77_RS31395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRI77_RS31405	COG0577	efflux transmembrane transporter activity
IRI77_RS31405	COG1136	(ABC) transporter
IRI77_RS31410	COG4993	Dehydrogenase
IRI77_RS31425	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRI77_RS31435	COG0003	Pfam Anion-transporting ATPase
IRI77_RS31440	COG0154	amidase activity
IRI77_RS31445	COG0463	Glycosyl transferase, family 2
IRI77_RS31450	COG0484	heat shock protein binding
IRI77_RS31455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IRI77_RS31460	COG1420	regulation of RNA biosynthetic process
IRI77_RS31465	COG3119	arylsulfatase activity
IRI77_RS31475	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS31485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRI77_RS31490	COG0659	secondary active sulfate transmembrane transporter activity
IRI77_RS31500	COG0471	metal ion transport
IRI77_RS31505	COG1321	iron dependent repressor
IRI77_RS31510	COG4774	siderophore transport
IRI77_RS31535	COG0308	aminopeptidase N
IRI77_RS31550	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IRI77_RS31555	COG2721	sulfolactate sulfo-lyase activity
IRI77_RS31560	COG2084	Dehydrogenase
IRI77_RS31565	COG0667	Aldo Keto reductase
IRI77_RS31570	COG2226	methyltransferase
IRI77_RS31580	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IRI77_RS31590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRI77_RS31605	COG1366	Belongs to the anti-sigma-factor antagonist family
IRI77_RS31615	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRI77_RS31615	COG1024	Enoyl-CoA hydratase
IRI77_RS31620	COG0183	Belongs to the thiolase family
IRI77_RS31625	COG1960	acyl-CoA dehydrogenase activity
IRI77_RS31640	COG0180	Tryptophanyl-tRNA synthetase
IRI77_RS31670	COG1058	Belongs to the CinA family
IRI77_RS31670	COG1546	Belongs to the CinA family
IRI77_RS31685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IRI77_RS31695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRI77_RS31725	COG1609	Transcriptional regulator
IRI77_RS31730	COG2271	Major facilitator Superfamily
IRI77_RS31735	COG0673	inositol 2-dehydrogenase activity
IRI77_RS31740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRI77_RS31775	COG2207	Transcriptional regulator
IRI77_RS31815	COG1136	(ABC) transporter
IRI77_RS31815	COG0577	efflux transmembrane transporter activity
IRI77_RS31820	COG1695	Transcriptional regulator
IRI77_RS31830	COG0047	phosphoribosylformylglycinamidine synthase activity
IRI77_RS31835	COG0657	acetylesterase activity
IRI77_RS31860	COG3344	reverse transcriptase
IRI77_RS31870	COG0488	(ABC) transporter
IRI77_RS31875	COG4124	Belongs to the glycosyl hydrolase 26 family
IRI77_RS31890	COG0515	serine threonine protein kinase
IRI77_RS31890	COG2815	serine threonine protein kinase
IRI77_RS31910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRI77_RS31920	COG1609	Transcriptional regulator
IRI77_RS31935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS31970	COG1136	(ABC) transporter
IRI77_RS31970	COG0577	efflux transmembrane transporter activity
IRI77_RS32000	COG2363	Small membrane protein
IRI77_RS32005	COG1408	metallophosphoesterase
IRI77_RS32010	COG0563	adenylate kinase activity
IRI77_RS32015	COG0436	Aminotransferase
IRI77_RS32030	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IRI77_RS32035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRI77_RS32065	COG0628	permease
IRI77_RS32070	COG0802	atpase or kinase
IRI77_RS32075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IRI77_RS32075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IRI77_RS32080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IRI77_RS32085	COG2770	Histidine kinase
IRI77_RS32085	COG2208	phosphoserine phosphatase activity
IRI77_RS32095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IRI77_RS32105	COG3118	belongs to the thioredoxin family
IRI77_RS32130	COG1013	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS32135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IRI77_RS32135	COG0674	pyruvate-flavodoxin oxidoreductase activity
IRI77_RS32160	COG1966	Carbon starvation protein
IRI77_RS32165	COG4191	Histidine kinase
IRI77_RS32185	COG2197	response regulator
IRI77_RS32200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRI77_RS32205	COG1609	Transcriptional regulator
IRI77_RS32220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRI77_RS32225	COG0577	efflux transmembrane transporter activity
IRI77_RS32255	COG2382	esterase
IRI77_RS32295	COG0577	efflux transmembrane transporter activity
IRI77_RS32295	COG1136	(ABC) transporter
IRI77_RS32320	COG3959	Transketolase, thiamine diphosphate binding domain
IRI77_RS32360	COG0714	Associated with various cellular activities
IRI77_RS32385	COG2271	Major facilitator Superfamily
IRI77_RS32420	COG2815	serine threonine protein kinase
IRI77_RS32420	COG0515	serine threonine protein kinase
IRI77_RS32425	COG1595	DNA-templated transcription, initiation
IRI77_RS32455	COG3700	Belongs to the class B bacterial acid phosphatase family
IRI77_RS32465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRI77_RS32480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IRI77_RS32520	COG4555	ABC transporter
IRI77_RS32570	COG0577	efflux transmembrane transporter activity
IRI77_RS32570	COG1136	(ABC) transporter
IRI77_RS32620	COG2208	phosphoserine phosphatase activity
IRI77_RS32620	COG2770	Histidine kinase
IRI77_RS32630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRI77_RS32630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRI77_RS32635	COG0191	fructose-bisphosphate aldolase activity
IRI77_RS32640	COG2311	Membrane
IRI77_RS32650	COG1073	alpha beta
IRI77_RS32665	COG1393	Belongs to the ArsC family
IRI77_RS32675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRI77_RS32685	COG0792	nuclease activity
IRI77_RS32690	COG1085	galactose-1-phosphate uridylyltransferase
IRI77_RS32725	COG0840	transmembrane signaling receptor activity
IRI77_RS32730	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS32735	COG2814	Major facilitator Superfamily
IRI77_RS32745	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS32755	COG3956	TIGRFAM MazG family protein
IRI77_RS32760	COG0456	acetyltransferase
IRI77_RS32785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS32790	COG0577	efflux transmembrane transporter activity
IRI77_RS32795	COG0577	efflux transmembrane transporter activity
IRI77_RS32795	COG1136	(ABC) transporter
IRI77_RS32835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRI77_RS32860	COG0673	inositol 2-dehydrogenase activity
IRI77_RS32875	COG0577	efflux transmembrane transporter activity
IRI77_RS32895	COG2226	methyltransferase
IRI77_RS32900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IRI77_RS32970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRI77_RS32990	COG3119	arylsulfatase activity
IRI77_RS32995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRI77_RS33010	COG0437	4 iron, 4 sulfur cluster binding
IRI77_RS33015	COG0427	acetyl-CoA hydrolase
IRI77_RS33020	COG0577	efflux transmembrane transporter activity
IRI77_RS33060	COG1136	(ABC) transporter
IRI77_RS33060	COG0577	efflux transmembrane transporter activity
IRI77_RS33070	COG0657	acetylesterase activity
IRI77_RS33070	COG2755	lipolytic protein G-D-S-L family
IRI77_RS33075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRI77_RS33080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS33105	COG1388	LysM domain
IRI77_RS33105	COG3942	CHAP domain
IRI77_RS33115	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IRI77_RS33120	COG3850	Histidine kinase
IRI77_RS33120	COG5002	protein histidine kinase activity
IRI77_RS33125	COG2204	response regulator
IRI77_RS33145	COG1454	alcohol dehydrogenase
IRI77_RS33145	COG1012	belongs to the aldehyde dehydrogenase family
IRI77_RS33155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IRI77_RS33155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IRI77_RS33160	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS33195	COG0840	transmembrane signaling receptor activity
IRI77_RS33210	COG1215	transferase activity, transferring glycosyl groups
IRI77_RS33255	COG0596	Alpha beta hydrolase
IRI77_RS33305	COG1706	bacterial-type flagellum-dependent cell motility
IRI77_RS33310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IRI77_RS33320	COG4786	Flagellar basal body rod
IRI77_RS33335	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IRI77_RS33345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS33355	COG1338	Plays a role in the flagellum-specific transport system
IRI77_RS33360	COG1987	bacterial-type flagellum assembly
IRI77_RS33370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRI77_RS33375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRI77_RS33380	COG1419	protein localization to endoplasmic reticulum
IRI77_RS33385	COG1191	sigma factor activity
IRI77_RS33390	COG1776	CheC inhibitor of MCP methylation
IRI77_RS33390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRI77_RS33400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS33415	COG1595	DNA-templated transcription, initiation
IRI77_RS33425	COG3852	Histidine kinase
IRI77_RS33430	COG0745	RESPONSE REGULATOR receiver
IRI77_RS33435	COG2204	response regulator
IRI77_RS33445	COG1085	galactose-1-phosphate uridylyltransferase
IRI77_RS33455	COG0515	serine threonine protein kinase
IRI77_RS33545	COG2815	serine threonine protein kinase
IRI77_RS33545	COG0515	serine threonine protein kinase
IRI77_RS33565	COG1609	Transcriptional regulator
IRI77_RS33575	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IRI77_RS33595	COG0154	amidase activity
IRI77_RS33605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IRI77_RS33610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRI77_RS33620	COG2885	chlorophyll binding
IRI77_RS33625	COG0823	Involved in the tonB-independent uptake of proteins
IRI77_RS33640	COG0811	peptide transport
IRI77_RS33645	COG0497	DNA recombination
IRI77_RS33675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS33685	COG4191	Histidine kinase
IRI77_RS33690	COG2204	response regulator
IRI77_RS33750	COG0673	inositol 2-dehydrogenase activity
IRI77_RS33755	COG3537	Alpha-1,2-mannosidase
IRI77_RS33790	COG2010	Cytochrome c
IRI77_RS33790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS33795	COG2080	2 iron, 2 sulfur cluster binding
IRI77_RS33870	COG3119	arylsulfatase activity
IRI77_RS33920	COG2062	phosphohistidine phosphatase, SixA
IRI77_RS33930	COG0579	oxidoreductase
IRI77_RS33945	COG0681	Belongs to the peptidase S26 family
IRI77_RS33995	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS34015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IRI77_RS34020	COG1643	Atp-dependent helicase
IRI77_RS34030	COG3850	Histidine kinase
IRI77_RS34030	COG4999	Histidine kinase
IRI77_RS34030	COG2205	protein histidine kinase activity
IRI77_RS34030	COG3437	response regulator, receiver
IRI77_RS34050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRI77_RS34065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IRI77_RS34065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IRI77_RS34070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRI77_RS34100	COG4555	ABC transporter
IRI77_RS34105	COG1505	serine-type exopeptidase activity
IRI77_RS34115	COG1381	Involved in DNA repair and RecF pathway recombination
IRI77_RS34120	COG0752	glycyl-tRNA synthetase alpha subunit
IRI77_RS34125	COG0751	glycine-tRNA ligase activity
IRI77_RS34130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IRI77_RS34130	COG0574	Belongs to the PEP-utilizing enzyme family
IRI77_RS34155	COG0163	prenyltransferase activity
IRI77_RS34180	COG0556	nucleotide-excision repair
IRI77_RS34190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRI77_RS34200	COG0527	aspartate kinase activity
IRI77_RS34205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IRI77_RS34210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS34260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IRI77_RS34265	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IRI77_RS34285	COG2010	Cytochrome c
IRI77_RS34285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IRI77_RS34295	COG2308	Evidence 4 Homologs of previously reported genes of
IRI77_RS34295	COG2307	Protein conserved in bacteria
IRI77_RS34300	COG1305	Transglutaminase-like
IRI77_RS34340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRI77_RS34345	COG0076	glutamate decarboxylase activity
IRI77_RS34400	COG1715	Restriction endonuclease
IRI77_RS34425	COG3459	Glycosyltransferase 36 associated
IRI77_RS34435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRI77_RS34440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRI77_RS34445	COG0356	it plays a direct role in the translocation of protons across the membrane
IRI77_RS34460	COG3591	Belongs to the peptidase S1B family
IRI77_RS34470	COG4191	Histidine kinase
IRI77_RS34475	COG2204	response regulator
IRI77_RS34480	COG2226	methyltransferase
IRI77_RS34505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS34510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IRI77_RS34515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRI77_RS34525	COG2706	6-phosphogluconolactonase activity
IRI77_RS34550	COG2890	protein-(glutamine-N5) methyltransferase activity
IRI77_RS34555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IRI77_RS34560	COG3872	metal-dependent enzyme
IRI77_RS34575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IRI77_RS34580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IRI77_RS34595	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS34600	COG1879	ABC-type sugar transport system periplasmic component
IRI77_RS34625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRI77_RS34630	COG1301	dicarboxylic acid transport
IRI77_RS34645	COG0123	including yeast histone deacetylase and acetoin utilization protein
IRI77_RS34655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRI77_RS34665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRI77_RS34675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IRI77_RS34680	COG1177	transmembrane transport
IRI77_RS34685	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRI77_RS34690	COG3842	ATPase activity
IRI77_RS34695	COG0393	Putative heavy-metal-binding
IRI77_RS34700	COG0590	tRNA wobble adenosine to inosine editing
IRI77_RS34710	COG0154	amidase activity
IRI77_RS34715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRI77_RS34725	COG0424	maF-like protein
IRI77_RS34790	COG0287	Prephenate dehydrogenase
IRI77_RS34795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IRI77_RS34805	COG0159	tryptophan synthase activity
IRI77_RS34810	COG0133	tryptophan synthase activity
IRI77_RS34815	COG0135	phosphoribosylanthranilate isomerase activity
IRI77_RS34820	COG0134	indole-3-glycerol-phosphate synthase activity
IRI77_RS34825	COG4771	TonB-dependent receptor
IRI77_RS34825	COG1629	transport
IRI77_RS34835	COG0531	amino acid
IRI77_RS34880	COG2226	methyltransferase
IRI77_RS34885	COG3385	transposase activity
IRI77_RS34910	COG1940	carbohydrate kinase activity
IRI77_RS34975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IRI77_RS34990	COG0196	riboflavin kinase activity
IRI77_RS34995	COG0321	lipoyl(octanoyl) transferase activity
IRI77_RS34995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IRI77_RS35010	COG0577	efflux transmembrane transporter activity
IRI77_RS35010	COG1136	(ABC) transporter
IRI77_RS35030	COG0450	alkyl hydroperoxide reductase
IRI77_RS35035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRI77_RS35055	COG2207	Transcriptional regulator
IRI77_RS35115	COG1136	(ABC) transporter
IRI77_RS35115	COG0577	efflux transmembrane transporter activity
IRI77_RS35170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IRI77_RS35200	COG4974	Belongs to the 'phage' integrase family
IRI77_RS35225	COG4974	Belongs to the 'phage' integrase family
IRI77_RS35240	COG3344	reverse transcriptase
IRI77_RS35255	COG4974	Belongs to the 'phage' integrase family
IRI77_RS35295	COG2208	phosphoserine phosphatase activity
IRI77_RS35330	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IRI77_RS35330	COG0778	Nitroreductase
IRI77_RS35335	COG0436	Aminotransferase
IRI77_RS35340	COG0456	acetyltransferase
IRI77_RS35370	COG0535	radical SAM domain protein
IRI77_RS35375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IRI77_RS35390	COG3119	arylsulfatase activity
IRI77_RS35395	COG0720	synthase
IRI77_RS35405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRI77_RS35420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRI77_RS35430	COG0673	inositol 2-dehydrogenase activity
IRI77_RS35450	COG0673	inositol 2-dehydrogenase activity
IRI77_RS35480	COG1486	melibiose metabolic process
IRI77_RS35485	COG0668	transmembrane transport
IRI77_RS35520	COG1899	peptidyl-lysine modification to peptidyl-hypusine
IRI77_RS35545	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IRI77_RS35550	COG0406	alpha-ribazole phosphatase activity
IRI77_RS35580	COG0673	inositol 2-dehydrogenase activity
IRI77_RS35655	COG3537	Alpha-1,2-mannosidase
IRI77_RS35660	COG3250	beta-galactosidase activity
IRI77_RS35705	COG5000	phosphorelay sensor kinase activity
IRI77_RS35770	COG0667	Aldo Keto reductase
IRI77_RS35775	COG0028	Belongs to the TPP enzyme family
IRI77_RS35780	COG0724	RNA recognition motif
IRI77_RS35785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRI77_RS35790	COG2197	response regulator
IRI77_RS35800	COG0288	reversible hydration of carbon dioxide
IRI77_RS35805	COG0659	secondary active sulfate transmembrane transporter activity
IRI77_RS35825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRI77_RS35870	COG1649	PFAM Uncharacterised BCR, COG1649
IRI77_RS35890	COG0215	cysteine-tRNA ligase activity
IRI77_RS35895	COG0343	queuine tRNA-ribosyltransferase activity
IRI77_RS35905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRI77_RS35910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRI77_RS35920	COG0811	peptide transport
IRI77_RS35960	COG1301	dicarboxylic acid transport
IRI77_RS35985	COG3150	esterase
IRI77_RS35990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRI77_RS35995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IRI77_RS36005	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRI77_RS36010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRI77_RS36010	COG2755	lipolytic protein G-D-S-L family
IRI77_RS36030	COG1595	DNA-templated transcription, initiation
IRI77_RS36035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IRI77_RS36040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IRI77_RS36060	COG3550	peptidyl-serine autophosphorylation
IRI77_RS36125	COG3534	alpha-L-arabinofuranosidase
IRI77_RS36130	COG3119	arylsulfatase activity
IRI77_RS36140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IRI77_RS36165	COG0596	Alpha beta hydrolase
IRI77_RS36185	COG0626	cystathionine gamma-synthase activity
IRI77_RS36195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS36245	COG1733	regulation of RNA biosynthetic process
IRI77_RS36250	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS36285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRI77_RS36360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRI77_RS36375	COG1131	(ABC) transporter
IRI77_RS36390	COG0702	epimerase
IRI77_RS36445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRI77_RS36455	COG1116	anion transmembrane transporter activity
IRI77_RS36460	COG2264	protein methyltransferase activity
IRI77_RS36580	COG1030	water channel activity
IRI77_RS36615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IRI77_RS36675	COG0515	serine threonine protein kinase
IRI77_RS36675	COG2815	serine threonine protein kinase
IRI77_RS36685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IRI77_RS36735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRI77_RS36795	COG2270	Major facilitator Superfamily
IRI77_RS36805	COG1132	(ABC) transporter
IRI77_RS36810	COG0463	Glycosyl transferase, family 2
IRI77_RS36815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IRI77_RS36820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRI77_RS36825	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IRI77_RS36835	COG0322	excinuclease ABC activity
IRI77_RS36850	COG0312	modulator of DNA gyrase
IRI77_RS36855	COG0312	modulator of DNA gyrase
IRI77_RS36870	COG1872	DUF167
IRI77_RS36880	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS36915	COG2208	phosphoserine phosphatase activity
IRI77_RS36915	COG2770	Histidine kinase
IRI77_RS36925	COG0284	orotidine-5'-phosphate decarboxylase activity
IRI77_RS36945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRI77_RS36970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IRI77_RS36975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IRI77_RS36980	COG0242	peptide deformylase activity
IRI77_RS36985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IRI77_RS37005	COG1136	(ABC) transporter
IRI77_RS37005	COG0577	efflux transmembrane transporter activity
IRI77_RS37045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IRI77_RS37050	COG1597	lipid kinase activity
IRI77_RS37085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRI77_RS37100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IRI77_RS37135	COG1136	(ABC) transporter
IRI77_RS37135	COG0577	efflux transmembrane transporter activity
IRI77_RS37150	COG0438	transferase activity, transferring glycosyl groups
IRI77_RS37155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IRI77_RS37160	COG0367	asparagine synthase
IRI77_RS37175	COG3830	Belongs to the UPF0237 family
IRI77_RS37175	COG0560	Phosphoserine phosphatase
IRI77_RS37205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRI77_RS37235	COG4591	ABC-type transport system involved in lipoprotein release permease component
IRI77_RS37265	COG3119	arylsulfatase activity
IRI77_RS37275	COG0149	triose-phosphate isomerase activity
IRI77_RS37295	COG1028	Short-chain dehydrogenase reductase Sdr
IRI77_RS37315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRI77_RS37330	COG1609	Transcriptional regulator
IRI77_RS37335	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IRI77_RS37360	COG2382	esterase
IRI77_RS37415	COG1136	(ABC) transporter
IRI77_RS37415	COG0577	efflux transmembrane transporter activity
IRI77_RS37475	COG2801	Transposase and inactivated derivatives
IRI77_RS37480	COG4221	oxidoreductase activity
IRI77_RS37490	COG1309	transcriptional regulator
IRI77_RS37495	COG4948	Mandelate Racemase Muconate Lactonizing
IRI77_RS37515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IRI77_RS37545	COG0667	Aldo Keto reductase
IRI77_RS37570	COG3093	addiction module antidote protein HigA
IRI77_RS37615	COG3415	Transposase
IRI77_RS37615	COG2801	Transposase and inactivated derivatives
IRI77_RS37640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IRI77_RS37655	COG1192	Involved in chromosome partitioning
IRI77_RS37710	COG0318	PFAM AMP-dependent synthetase and ligase
IRI77_RS37715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRI77_RS37720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRI77_RS37720	COG2755	lipolytic protein G-D-S-L family
IRI77_RS37725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRI77_RS37725	COG2755	lipolytic protein G-D-S-L family
IRI77_RS37775	COG0438	transferase activity, transferring glycosyl groups