locus-tag	class	description
AA956_RS00030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA956_RS00035	COG4774	siderophore transport
AA956_RS00040	COG3712	iron ion homeostasis
AA956_RS00045	COG1595	DNA-templated transcription, initiation
AA956_RS00060	COG3396	Phenylacetate-CoA oxygenase
AA956_RS00065	COG3460	Phenylacetate-CoA oxygenase
AA956_RS00070	COG3396	Phenylacetate-CoA oxygenase
AA956_RS00075	COG2151	metal-sulfur cluster biosynthetic enzyme
AA956_RS00080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA956_RS00100	COG1522	sequence-specific DNA binding
AA956_RS00120	COG2814	Major facilitator Superfamily
AA956_RS00125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA956_RS00140	COG2226	methyltransferase
AA956_RS00145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS00170	COG4451	ribulose bisphosphate carboxylase, small
AA956_RS00170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA956_RS00180	COG0513	Belongs to the DEAD box helicase family
AA956_RS00185	COG0583	DNA-binding transcription factor activity
AA956_RS00190	COG2233	PERMEase
AA956_RS00205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AA956_RS00210	COG2827	Endonuclease containing a URI domain
AA956_RS00270	COG2814	Major facilitator Superfamily
AA956_RS00280	COG0583	DNA-binding transcription factor activity
AA956_RS00290	COG1845	cytochrome c oxidase, subunit III
AA956_RS00295	COG1845	cytochrome c oxidase, subunit III
AA956_RS00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA956_RS00305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA956_RS00320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA956_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS00360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA956_RS00365	COG0463	Glycosyl transferase, family 2
AA956_RS00410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AA956_RS00410	COG0662	Cupin 2, conserved barrel domain protein
AA956_RS00425	COG0737	Belongs to the 5'-nucleotidase family
AA956_RS00435	COG2010	Cytochrome c
AA956_RS00455	COG4654	Cytochrome c, class I
AA956_RS00460	COG4654	Cytochrome c, class I
AA956_RS00465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA956_RS00480	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA956_RS00490	COG2823	Periplasmic or secreted lipoprotein
AA956_RS00495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AA956_RS00500	COG0792	nuclease activity
AA956_RS00510	COG1122	ATPase activity
AA956_RS00530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA956_RS00555	COG3622	Belongs to the hyi family
AA956_RS00560	COG1832	CoA-binding protein
AA956_RS00565	COG0657	acetylesterase activity
AA956_RS00575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA956_RS00580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA956_RS00595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AA956_RS00595	COG0506	proline dehydrogenase activity
AA956_RS00595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AA956_RS00615	COG1115	amino acid carrier protein
AA956_RS00625	COG1760	l-serine dehydratase
AA956_RS00635	COG0509	glycine decarboxylation via glycine cleavage system
AA956_RS00640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA956_RS00650	COG0210	DNA helicase
AA956_RS00660	COG3245	cytochrome
AA956_RS00675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AA956_RS00680	COG2205	protein histidine kinase activity
AA956_RS00685	COG0745	RESPONSE REGULATOR receiver
AA956_RS00700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS00710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS00715	COG0745	RESPONSE REGULATOR receiver
AA956_RS00725	COG3851	Histidine kinase
AA956_RS00730	COG2197	response regulator
AA956_RS00760	COG2257	FlhB HrpN YscU SpaS Family
AA956_RS00765	COG1677	Flagellar hook-basal body complex protein FliE
AA956_RS00780	COG1317	bacterial-type flagellum organization
AA956_RS00800	COG1580	Controls the rotational direction of flagella during chemotaxis
AA956_RS00820	COG1338	Plays a role in the flagellum-specific transport system
AA956_RS00835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA956_RS00840	COG1256	bacterial-type flagellum assembly
AA956_RS00850	COG1706	bacterial-type flagellum-dependent cell motility
AA956_RS00855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AA956_RS00865	COG4787	bacterial-type flagellum-dependent cell motility
AA956_RS00880	COG1558	bacterial-type flagellum-dependent cell motility
AA956_RS00885	COG1815	bacterial-type flagellum-dependent cell motility
AA956_RS00905	COG1191	sigma factor activity
AA956_RS00920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA956_RS00930	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AA956_RS00935	COG0745	RESPONSE REGULATOR receiver
AA956_RS00945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AA956_RS00950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA956_RS00955	COG0840	transmembrane signaling receptor activity
AA956_RS00960	COG0840	transmembrane signaling receptor activity
AA956_RS00965	COG0840	transmembrane signaling receptor activity
AA956_RS00970	COG0835	chemotaxis
AA956_RS00975	COG0643	Histidine kinase
AA956_RS00975	COG2198	Histidine kinase
AA956_RS00980	COG2198	Histidine kinase
AA956_RS00980	COG0784	Response regulator, receiver
AA956_RS00980	COG2205	protein histidine kinase activity
AA956_RS00985	COG1360	Flagellar Motor Protein
AA956_RS01005	COG2814	Major facilitator Superfamily
AA956_RS01010	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS01015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA956_RS01020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA956_RS01025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA956_RS01040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA956_RS01050	COG0356	it plays a direct role in the translocation of protons across the membrane
AA956_RS01060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AA956_RS01065	COG1475	DNA binding
AA956_RS01070	COG1192	Involved in chromosome partitioning
AA956_RS01075	COG3040	lipid binding
AA956_RS01080	COG0357	Ribosomal RNA small subunit methyltransferase G
AA956_RS01085	COG0445	tRNA wobble uridine modification
AA956_RS01105	COG1846	Transcriptional regulator
AA956_RS01165	COG0583	DNA-binding transcription factor activity
AA956_RS01210	COG1522	sequence-specific DNA binding
AA956_RS01215	COG4771	TonB-dependent receptor
AA956_RS01220	COG3720	iron ion transport
AA956_RS01225	COG4558	Periplasmic binding protein
AA956_RS01230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA956_RS01240	COG2423	ornithine cyclodeaminase activity
AA956_RS01250	COG1522	sequence-specific DNA binding
AA956_RS01255	COG4771	TonB-dependent receptor
AA956_RS01260	COG3720	iron ion transport
AA956_RS01265	COG4558	Periplasmic binding protein
AA956_RS01270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA956_RS01280	COG2423	ornithine cyclodeaminase activity
AA956_RS01285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA956_RS01305	COG1522	sequence-specific DNA binding
AA956_RS01310	COG3186	Phenylalanine-4-hydroxylase
AA956_RS01315	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA956_RS01340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS01340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA956_RS01345	COG0038	chloride channel
AA956_RS01350	COG1846	Transcriptional regulator
AA956_RS01360	COG2814	Major facilitator Superfamily
AA956_RS01365	COG5001	Diguanylate cyclase
AA956_RS01365	COG3300	MHYT domain
AA956_RS01400	COG0706	membrane insertase activity
AA956_RS01405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA956_RS01410	COG0594	ribonuclease P activity
AA956_RS01415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA956_RS01445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AA956_RS01455	COG1396	sequence-specific DNA binding
AA956_RS01515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS01520	COG1137	ATPase activity
AA956_RS01540	COG1414	Transcriptional regulator
AA956_RS01545	COG0833	amino acid
AA956_RS01570	COG1396	sequence-specific DNA binding
AA956_RS01575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS01585	COG0583	DNA-binding transcription factor activity
AA956_RS01595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA956_RS01600	COG3829	transcription factor binding
AA956_RS01610	COG0477	Major facilitator Superfamily
AA956_RS01615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS01620	COG1802	Transcriptional regulator
AA956_RS01680	COG0840	transmembrane signaling receptor activity
AA956_RS01685	COG0477	Major facilitator Superfamily
AA956_RS01695	COG1131	(ABC) transporter
AA956_RS01715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AA956_RS01725	COG0583	DNA-binding transcription factor activity
AA956_RS01730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS01735	COG0765	amino acid transport
AA956_RS01740	COG0765	amino acid transport
AA956_RS01780	COG1252	NADH dehydrogenase
AA956_RS01785	COG1309	transcriptional regulator
AA956_RS01805	COG4774	siderophore transport
AA956_RS01810	COG3712	iron ion homeostasis
AA956_RS01820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA956_RS01840	COG1968	undecaprenyl-diphosphatase activity
AA956_RS01845	COG0583	DNA-binding transcription factor activity
AA956_RS01870	COG2252	PERMEase
AA956_RS01875	COG0583	DNA-binding transcription factor activity
AA956_RS01890	COG2733	membrane
AA956_RS01895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA956_RS01930	COG0583	DNA-binding transcription factor activity
AA956_RS01940	COG0583	DNA-binding transcription factor activity
AA956_RS01945	COG2814	Major facilitator Superfamily
AA956_RS01960	COG2200	EAL domain
AA956_RS01960	COG2771	luxR family
AA956_RS01965	COG2223	nitrite transmembrane transporter activity
AA956_RS01980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA956_RS01990	COG0840	transmembrane signaling receptor activity
AA956_RS02000	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA956_RS02000	COG0457	Tetratricopeptide repeat
AA956_RS02005	COG0835	chemotaxis
AA956_RS02015	COG2201	protein-glutamate methylesterase activity
AA956_RS02020	COG2203	Gaf domain
AA956_RS02020	COG4251	negative regulation of phosphorylation
AA956_RS02020	COG3706	GGDEF domain
AA956_RS02020	COG5001	Diguanylate cyclase
AA956_RS02045	COG1473	amidohydrolase
AA956_RS02090	COG1802	Transcriptional regulator
AA956_RS02095	COG2957	Belongs to the agmatine deiminase family
AA956_RS02110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS02120	COG4774	siderophore transport
AA956_RS02125	COG3128	pkhd-type hydroxylase
AA956_RS02155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA956_RS02160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AA956_RS02180	COG1966	Carbon starvation protein
AA956_RS02185	COG2879	small protein
AA956_RS02195	COG0583	DNA-binding transcription factor activity
AA956_RS02210	COG0758	DNA mediated transformation
AA956_RS02210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA956_RS02215	COG0242	peptide deformylase activity
AA956_RS02230	COG0501	Belongs to the peptidase M48B family
AA956_RS02235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA956_RS02235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA956_RS02245	COG5000	phosphorelay sensor kinase activity
AA956_RS02250	COG2204	response regulator
AA956_RS02250	COG2204	response regulator
AA956_RS02265	COG0602	queuosine metabolic process
AA956_RS02270	COG0720	synthase
AA956_RS02285	COG0772	Belongs to the SEDS family
AA956_RS02290	COG0768	penicillin binding
AA956_RS02300	COG1792	Involved in formation and maintenance of cell shape
AA956_RS02305	COG1077	Cell shape determining protein MreB Mrl
AA956_RS02310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA956_RS02325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA956_RS02330	COG2326	polyphosphate kinase activity
AA956_RS02335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS02370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA956_RS02390	COG1960	acyl-CoA dehydrogenase activity
AA956_RS02400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA956_RS02405	COG1560	Kdo2-lipid A biosynthetic process
AA956_RS02410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA956_RS02420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AA956_RS02425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA956_RS02440	COG0523	cobalamin synthesis protein
AA956_RS02455	COG4206	TonB-dependent receptor
AA956_RS02460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA956_RS02470	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA956_RS02490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA956_RS02520	COG0477	Major facilitator Superfamily
AA956_RS02535	COG2188	Transcriptional regulator
AA956_RS02545	COG3384	dioxygenase
AA956_RS02555	COG0683	leucine binding
AA956_RS02575	COG0410	ABC transporter
AA956_RS02580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AA956_RS02585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA956_RS02590	COG2828	Protein conserved in bacteria
AA956_RS02605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS02610	COG2814	Major facilitator Superfamily
AA956_RS02620	COG1309	transcriptional regulator
AA956_RS02625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA956_RS02630	COG2813	Specifically methylates the guanine in position
AA956_RS02630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA956_RS02635	COG2814	Major facilitator Superfamily
AA956_RS02645	COG0708	Exodeoxyribonuclease III
AA956_RS02650	COG0583	DNA-binding transcription factor activity
AA956_RS02655	COG1380	Effector of murein hydrolase LrgA
AA956_RS02660	COG1346	cytolysis
AA956_RS02665	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA956_RS02670	COG1950	PFAM Membrane protein of
AA956_RS02675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AA956_RS02680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AA956_RS02685	COG0747	negative chemotaxis
AA956_RS02690	COG0601	transmembrane transport
AA956_RS02695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA956_RS02700	COG0444	Belongs to the ABC transporter superfamily
AA956_RS02705	COG4608	Belongs to the ABC transporter superfamily
AA956_RS02715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA956_RS02720	COG0830	nickel cation binding
AA956_RS02730	COG0804	urea catabolic process
AA956_RS02735	COG0832	Belongs to the urease beta subunit family
AA956_RS02745	COG0831	urea catabolic process
AA956_RS02750	COG1126	abc transporter atp-binding protein
AA956_RS02755	COG0765	amino acid transport
AA956_RS02760	COG0765	amino acid transport
AA956_RS02805	COG2814	Major facilitator Superfamily
AA956_RS02820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS02825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AA956_RS02830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AA956_RS02835	COG1984	allophanate hydrolase subunit 2
AA956_RS02840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AA956_RS02860	COG0625	glutathione transferase activity
AA956_RS02910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA956_RS02920	COG2271	Major facilitator Superfamily
AA956_RS02925	COG3048	D-serine ammonia-lyase activity
AA956_RS02935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA956_RS02940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS02950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS02955	COG3842	ATPase activity
AA956_RS02975	COG0642	Histidine kinase
AA956_RS02990	COG0038	chloride channel
AA956_RS03040	COG0583	DNA-binding transcription factor activity
AA956_RS03055	COG0625	glutathione transferase activity
AA956_RS03060	COG0583	DNA-binding transcription factor activity
AA956_RS03105	COG0583	DNA-binding transcription factor activity
AA956_RS03130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA956_RS03130	COG2169	Transcriptional regulator
AA956_RS03160	COG1741	Belongs to the pirin family
AA956_RS03170	COG1739	Uncharacterized protein family UPF0029
AA956_RS03180	COG2132	Multicopper oxidase
AA956_RS03225	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA956_RS03270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA956_RS03275	COG4681	YaeQ
AA956_RS03295	COG0697	spore germination
AA956_RS03300	COG3706	GGDEF domain
AA956_RS03315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS03325	COG2207	Transcriptional regulator
AA956_RS03335	COG4770	biotin carboxylase activity
AA956_RS03340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA956_RS03345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA956_RS03350	COG0156	8-amino-7-oxononanoate synthase activity
AA956_RS03360	COG1024	Enoyl-CoA hydratase
AA956_RS03365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA956_RS03370	COG3012	SEC-C Motif Domain Protein
AA956_RS03380	COG0300	oxidoreductase activity
AA956_RS03385	COG0183	Belongs to the thiolase family
AA956_RS03390	COG0288	reversible hydration of carbon dioxide
AA956_RS03395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AA956_RS03400	COG1960	acyl-CoA dehydrogenase activity
AA956_RS03410	COG0789	Transcriptional regulator
AA956_RS03415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA956_RS03435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA956_RS03445	COG0018	arginyl-trna synthetase
AA956_RS03465	COG1410	methionine synthase
AA956_RS03465	COG0646	methionine synthase
AA956_RS03485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA956_RS03510	COG1024	Enoyl-CoA hydratase
AA956_RS03550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA956_RS03575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA956_RS03580	COG1127	ABC transporter
AA956_RS03600	COG0477	Major facilitator Superfamily
AA956_RS03615	COG1686	Belongs to the peptidase S11 family
AA956_RS03620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AA956_RS03625	COG2921	Belongs to the UPF0250 family
AA956_RS03630	COG0583	DNA-binding transcription factor activity
AA956_RS03645	COG0321	lipoyl(octanoyl) transferase activity
AA956_RS03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS03675	COG1116	anion transmembrane transporter activity
AA956_RS03685	COG4191	Histidine kinase
AA956_RS03690	COG2204	response regulator
AA956_RS03710	COG0606	chelatase, subunit chli
AA956_RS03715	COG2960	long-chain fatty acid transporting porin activity
AA956_RS03725	COG0347	Belongs to the P(II) protein family
AA956_RS03730	COG0004	ammonium transporteR
AA956_RS03745	COG0189	ligase activity
AA956_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AA956_RS03760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA956_RS03765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA956_RS03770	COG0793	Belongs to the peptidase S41A family
AA956_RS03780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA956_RS03785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AA956_RS03790	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AA956_RS03800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AA956_RS03810	COG1040	competence protein
AA956_RS03815	COG2226	methyltransferase
AA956_RS03820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA956_RS03825	COG2423	ornithine cyclodeaminase activity
AA956_RS03830	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA956_RS03840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA956_RS03845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA956_RS03855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS03875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA956_RS03880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AA956_RS03910	COG1612	heme a metabolic process
AA956_RS03920	COG1999	signal sequence binding
AA956_RS03930	COG1294	oxidase, subunit
AA956_RS03945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA956_RS03955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA956_RS03960	COG0625	glutathione transferase activity
AA956_RS03975	COG0612	Peptidase, M16
AA956_RS03980	COG0612	Peptidase, M16
AA956_RS03990	COG1131	(ABC) transporter
AA956_RS03995	COG0742	ribosomal rna small subunit methyltransferase
AA956_RS04000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA956_RS04005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AA956_RS04010	COG0193	aminoacyl-tRNA hydrolase activity
AA956_RS04020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA956_RS04035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AA956_RS04050	COG1194	a g-specific adenine glycosylase
AA956_RS04055	COG1660	Displays ATPase and GTPase activities
AA956_RS04065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AA956_RS04075	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA956_RS04080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AA956_RS04085	COG1137	ATPase activity
AA956_RS04100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA956_RS04115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA956_RS04120	COG1280	lysine exporter protein (LysE YggA)
AA956_RS04130	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA956_RS04135	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AA956_RS04140	COG3639	organic phosphonate transmembrane transporter activity
AA956_RS04145	COG3454	Phosphonate metabolism
AA956_RS04150	COG4778	phosphonate C-P lyase system protein PhnL
AA956_RS04155	COG4107	phosphonate C-P lyase system protein PhnK
AA956_RS04160	COG3627	carbon phosphorus lyase activity
AA956_RS04165	COG3626	phosphonate metabolism
AA956_RS04170	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AA956_RS04175	COG3624	Phosphonate C-P lyase system protein PhnG
AA956_RS04180	COG2188	Transcriptional regulator
AA956_RS04185	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AA956_RS04210	COG0477	Major facilitator Superfamily
AA956_RS04220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA956_RS04230	COG3842	ATPase activity
AA956_RS04235	COG1840	ABC-type Fe3 transport system, periplasmic component
AA956_RS04250	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS04255	COG1283	sodium-dependent phosphate transmembrane transporter activity
AA956_RS04270	COG0251	oxidation-reduction process
AA956_RS04295	COG2814	Major facilitator Superfamily
AA956_RS04300	COG0629	single-stranded DNA binding
AA956_RS04305	COG1418	mRNA catabolic process
AA956_RS04310	COG1473	amidohydrolase
AA956_RS04315	COG1802	Transcriptional regulator
AA956_RS04325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS04330	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS04360	COG0625	glutathione transferase activity
AA956_RS04390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS04395	COG0667	Aldo Keto reductase
AA956_RS04400	COG2207	Transcriptional regulator
AA956_RS04425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA956_RS04430	COG2271	Major facilitator Superfamily
AA956_RS04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS04440	COG0625	glutathione transferase activity
AA956_RS04460	COG0632	four-way junction helicase activity
AA956_RS04465	COG0583	DNA-binding transcription factor activity
AA956_RS04475	COG0477	Major facilitator Superfamily
AA956_RS04480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA956_RS04490	COG4172	Belongs to the ABC transporter superfamily
AA956_RS04500	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS04505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA956_RS04525	COG3321	synthase
AA956_RS04525	COG0604	alcohol dehydrogenase
AA956_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS04555	COG0765	amino acid transport
AA956_RS04560	COG0010	Belongs to the arginase family
AA956_RS04565	COG1126	abc transporter atp-binding protein
AA956_RS04635	COG2610	gluconate transmembrane transporter activity
AA956_RS04645	COG1733	regulation of RNA biosynthetic process
AA956_RS04650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS04655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS04660	COG0656	L-ascorbic acid biosynthetic process
AA956_RS04665	COG3038	cytochrome b561
AA956_RS04670	COG4771	TonB-dependent receptor
AA956_RS04680	COG3047	cAMP biosynthetic process
AA956_RS04690	COG1139	Iron-sulfur cluster binding protein
AA956_RS04695	COG0247	lactate metabolic process
AA956_RS04700	COG1620	l-lactate permease
AA956_RS04705	COG2186	Transcriptional regulator
AA956_RS04715	COG0583	DNA-binding transcription factor activity
AA956_RS04730	COG0625	glutathione transferase activity
AA956_RS04740	COG1448	Aminotransferase
AA956_RS04760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA956_RS04765	COG0183	Belongs to the thiolase family
AA956_RS04770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AA956_RS04780	COG1414	Transcriptional regulator
AA956_RS04830	COG2814	Major facilitator Superfamily
AA956_RS04845	COG0583	DNA-binding transcription factor activity
AA956_RS04850	COG0473	3-isopropylmalate dehydrogenase activity
AA956_RS04855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS04870	COG0047	phosphoribosylformylglycinamidine synthase activity
AA956_RS04875	COG0583	DNA-binding transcription factor activity
AA956_RS04880	COG1902	pentaerythritol trinitrate reductase activity
AA956_RS04905	COG1414	Transcriptional regulator
AA956_RS04910	COG1414	Transcriptional regulator
AA956_RS04925	COG0730	response to heat
AA956_RS04955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA956_RS04960	COG1228	amidohydrolase
AA956_RS04970	COG1113	amino acid transport
AA956_RS04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS04980	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA956_RS04985	COG4521	taurine ABC transporter
AA956_RS04990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS04995	COG0625	glutathione transferase activity
AA956_RS05000	COG5001	Diguanylate cyclase
AA956_RS05035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA956_RS05050	COG2271	Major facilitator Superfamily
AA956_RS05120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA956_RS05140	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA956_RS05220	COG3547	Transposase (IS116 IS110 IS902 family)
AA956_RS05260	COG0477	Major facilitator Superfamily
AA956_RS05280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AA956_RS05305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA956_RS05305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA956_RS05315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA956_RS05325	COG1238	metal cluster binding
AA956_RS05345	COG0025	NhaP-type Na H and K H
AA956_RS05360	COG2226	methyltransferase
AA956_RS05375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA956_RS05380	COG0500	methyltransferase
AA956_RS05400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA956_RS05405	COG0494	nUDIX hydrolase
AA956_RS05410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA956_RS05420	COG1960	acyl-CoA dehydrogenase activity
AA956_RS05425	COG1024	Enoyl-CoA hydratase
AA956_RS05425	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA956_RS05430	COG0183	Belongs to the thiolase family
AA956_RS05445	COG5265	(ABC) transporter
AA956_RS05455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA956_RS05465	COG0765	amino acid transport
AA956_RS05470	COG0765	amino acid transport
AA956_RS05475	COG1126	abc transporter atp-binding protein
AA956_RS05480	COG0121	glutamine amidotransferase
AA956_RS05485	COG0418	dihydroorotase activity
AA956_RS05500	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA956_RS05505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA956_RS05510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA956_RS05515	COG0316	Belongs to the HesB IscA family
AA956_RS05520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA956_RS05525	COG0739	heme binding
AA956_RS05540	COG1881	PFAM PEBP family protein
AA956_RS05545	COG0406	alpha-ribazole phosphatase activity
AA956_RS05555	COG2255	four-way junction helicase activity
AA956_RS05560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA956_RS05565	COG1981	membrane
AA956_RS05575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA956_RS05580	COG1737	Transcriptional regulator
AA956_RS05590	COG0800	Aldolase
AA956_RS05600	COG3265	gluconokinase activity
AA956_RS05615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA956_RS05640	COG0482	sulfurtransferase activity
AA956_RS05645	COG0069	glutamate synthase activity
AA956_RS05650	COG2207	Transcriptional regulator
AA956_RS05715	COG2197	response regulator
AA956_RS05785	COG3909	cytochrome
AA956_RS05800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA956_RS05805	COG1862	Preprotein translocase
AA956_RS05810	COG0343	queuine tRNA-ribosyltransferase activity
AA956_RS05820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA956_RS05830	COG0753	catalase activity
AA956_RS05835	COG0352	thiamine-phosphate diphosphorylase activity
AA956_RS05840	COG0783	Belongs to the Dps family
AA956_RS05850	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AA956_RS05870	COG1741	Belongs to the pirin family
AA956_RS05895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA956_RS05920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA956_RS05930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA956_RS05980	COG1396	sequence-specific DNA binding
AA956_RS06105	COG0154	amidase activity
AA956_RS06110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA956_RS06115	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS06120	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AA956_RS06130	COG1879	ABC-type sugar transport system periplasmic component
AA956_RS06135	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA956_RS06140	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA956_RS06145	COG1129	ABC transporter
AA956_RS06150	COG0583	DNA-binding transcription factor activity
AA956_RS06160	COG4948	Mandelate Racemase Muconate Lactonizing
AA956_RS06175	COG0583	DNA-binding transcription factor activity
AA956_RS06195	COG3842	ATPase activity
AA956_RS06205	COG0395	ABC-type sugar transport system, permease component
AA956_RS06210	COG3938	Belongs to the proline racemase family
AA956_RS06240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AA956_RS06250	COG4566	intracellular signal transduction
AA956_RS06255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA956_RS06270	COG0811	peptide transport
AA956_RS06345	COG1297	OPT oligopeptide transporter protein
AA956_RS06350	COG0477	Major facilitator Superfamily
AA956_RS06355	COG1686	Belongs to the peptidase S11 family
AA956_RS06360	COG1464	Belongs to the NlpA lipoprotein family
AA956_RS06365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA956_RS06370	COG2011	ABC-type metal ion transport system permease component
AA956_RS06385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS06395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AA956_RS06400	COG1845	cytochrome c oxidase, subunit III
AA956_RS06405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA956_RS06410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA956_RS06415	COG0477	Major facilitator Superfamily
AA956_RS06425	COG0444	Belongs to the ABC transporter superfamily
AA956_RS06430	COG4608	Belongs to the ABC transporter superfamily
AA956_RS06435	COG0747	negative chemotaxis
AA956_RS06440	COG0601	transmembrane transport
AA956_RS06445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA956_RS06455	COG2814	Major facilitator Superfamily
AA956_RS06465	COG0583	DNA-binding transcription factor activity
AA956_RS06470	COG2198	Histidine kinase
AA956_RS06470	COG0643	Histidine kinase
AA956_RS06475	COG0840	transmembrane signaling receptor activity
AA956_RS06500	COG2814	Major facilitator Superfamily
AA956_RS06505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS06510	COG1024	Enoyl-CoA hydratase
AA956_RS06515	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS06525	COG1960	acyl-CoA dehydrogenase activity
AA956_RS06535	COG0583	DNA-binding transcription factor activity
AA956_RS06540	COG3485	protocatechuate 3,4-dioxygenase
AA956_RS06545	COG3485	protocatechuate 3,4-dioxygenase
AA956_RS06555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA956_RS06560	COG0596	Alpha beta hydrolase
AA956_RS06565	COG1917	Cupin 2, conserved barrel domain protein
AA956_RS06565	COG2207	Transcriptional regulator
AA956_RS06575	COG2814	Major facilitator Superfamily
AA956_RS06595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS06610	COG1288	antiporter activity
AA956_RS06630	COG3634	alkyl hydroperoxide reductase activity
AA956_RS06680	COG1191	sigma factor activity
AA956_RS06685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AA956_RS06730	COG4786	Flagellar basal body rod
AA956_RS06785	COG1987	bacterial-type flagellum assembly
AA956_RS06810	COG4149	molybdate abc transporter
AA956_RS06820	COG3842	ATPase activity
AA956_RS06825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS06830	COG2205	protein histidine kinase activity
AA956_RS06835	COG0745	RESPONSE REGULATOR receiver
AA956_RS06890	COG3237	CsbD-like
AA956_RS06895	COG4585	Histidine kinase
AA956_RS06920	COG2201	protein-glutamate methylesterase activity
AA956_RS06925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA956_RS06930	COG2011	ABC-type metal ion transport system permease component
AA956_RS06940	COG3300	MHYT domain
AA956_RS06940	COG5001	Diguanylate cyclase
AA956_RS06945	COG0531	amino acid
AA956_RS06955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA956_RS06965	COG0436	Aminotransferase
AA956_RS06970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA956_RS06975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA956_RS06985	COG0640	Transcriptional regulator
AA956_RS07030	COG3971	2-oxopent-4-enoate hydratase activity
AA956_RS07040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA956_RS07040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA956_RS07055	COG1704	LemA family
AA956_RS07060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA956_RS07065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA956_RS07070	COG0671	phosphoesterase, PA-phosphatase related
AA956_RS07075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA956_RS07085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS07100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA956_RS07110	COG0837	glucose binding
AA956_RS07110	COG1737	Transcriptional regulator
AA956_RS07120	COG3360	Dodecin
AA956_RS07125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA956_RS07135	COG0443	Heat shock 70 kDa protein
AA956_RS07140	COG2814	Major facilitator Superfamily
AA956_RS07150	COG0640	Transcriptional regulator
AA956_RS07160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA956_RS07175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS07190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS07210	COG1414	Transcriptional regulator
AA956_RS07220	COG0028	Belongs to the TPP enzyme family
AA956_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS07235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS07270	COG0386	Belongs to the glutathione peroxidase family
AA956_RS07295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS07310	COG2271	Major facilitator Superfamily
AA956_RS07320	COG3246	L-lysine catabolic process to acetate
AA956_RS07340	COG0210	DNA helicase
AA956_RS07425	COG0582	viral genome integration into host DNA
AA956_RS07435	COG2084	Dehydrogenase
AA956_RS07445	COG0583	DNA-binding transcription factor activity
AA956_RS07450	COG0730	response to heat
AA956_RS07455	COG0175	sulfate reduction
AA956_RS07465	COG2895	sulfate adenylyltransferase (ATP) activity
AA956_RS07470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA956_RS07470	COG1648	precorrin-2 dehydrogenase activity
AA956_RS07480	COG0795	lipopolysaccharide-transporting ATPase activity
AA956_RS07485	COG0795	lipopolysaccharide-transporting ATPase activity
AA956_RS07490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA956_RS07515	COG1289	transmembrane transporter activity
AA956_RS07520	COG1566	PFAM secretion protein HlyD family protein
AA956_RS07535	COG0129	dihydroxy-acid dehydratase activity
AA956_RS07540	COG0583	DNA-binding transcription factor activity
AA956_RS07545	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA956_RS07550	COG1802	Transcriptional regulator
AA956_RS07555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA956_RS07575	COG1024	Enoyl-CoA hydratase
AA956_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS07615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA956_RS07625	COG0287	Prephenate dehydrogenase
AA956_RS07630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA956_RS07635	COG1914	H( )-stimulated, divalent metal cation uptake system
AA956_RS07640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA956_RS07650	COG0776	regulation of translation
AA956_RS07660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AA956_RS07670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA956_RS07675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA956_RS07690	COG2951	lytic endotransglycosylase activity
AA956_RS07700	COG1024	Enoyl-CoA hydratase
AA956_RS07725	COG1960	acyl-CoA dehydrogenase activity
AA956_RS07740	COG4206	TonB-dependent receptor
AA956_RS07745	COG4139	cobalamin transport
AA956_RS07750	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA956_RS07760	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA956_RS07765	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA956_RS07775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA956_RS07800	COG1492	cobalamin metabolic process
AA956_RS07805	COG0489	protein tyrosine kinase activity
AA956_RS07810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA956_RS07815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA956_RS07835	COG2911	Protein conserved in bacteria
AA956_RS07850	COG1522	sequence-specific DNA binding
AA956_RS07855	COG2226	methyltransferase
AA956_RS07865	COG2885	chlorophyll binding
AA956_RS07870	COG0489	protein tyrosine kinase activity
AA956_RS07875	COG0717	Belongs to the dCTP deaminase family
AA956_RS07885	COG0786	glutamate:sodium symporter activity
AA956_RS07890	COG0165	Argininosuccinate lyase
AA956_RS07905	COG0181	hydroxymethylbilane synthase activity
AA956_RS07930	COG0477	Major facilitator Superfamily
AA956_RS07935	COG2271	Major facilitator Superfamily
AA956_RS07950	COG0277	FAD linked oxidase domain protein
AA956_RS07965	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA956_RS07970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS07985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA956_RS07995	COG2249	NAD(P)H dehydrogenase (quinone) activity
AA956_RS08015	COG2860	membrane
AA956_RS08020	COG1193	negative regulation of DNA recombination
AA956_RS08025	COG0492	ferredoxin-NADP+ reductase activity
AA956_RS08030	COG1674	ftsk spoiiie
AA956_RS08035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AA956_RS08040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA956_RS08045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA956_RS08055	COG2267	carboxylic ester hydrolase activity
AA956_RS08060	COG2814	Major facilitator Superfamily
AA956_RS08065	COG3971	2-oxopent-4-enoate hydratase activity
AA956_RS08070	COG3384	dioxygenase
AA956_RS08075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS08080	COG1414	Transcriptional regulator
AA956_RS08095	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AA956_RS08110	COG2186	Transcriptional regulator
AA956_RS08130	COG0625	glutathione transferase activity
AA956_RS08140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS08155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA956_RS08175	COG2851	Citrate transporter
AA956_RS08180	COG0583	DNA-binding transcription factor activity
AA956_RS08220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS08230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS08235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS08245	COG1802	Transcriptional regulator
AA956_RS08260	COG0667	Aldo Keto reductase
AA956_RS08265	COG3284	Transcriptional regulator
AA956_RS08270	COG0583	DNA-binding transcription factor activity
AA956_RS08275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS08305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA956_RS08315	COG1349	DNA-binding transcription factor activity
AA956_RS08325	COG3395	kinase activity
AA956_RS08330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA956_RS08345	COG0235	Class ii aldolase
AA956_RS08355	COG0477	Major facilitator Superfamily
AA956_RS08370	COG1595	DNA-templated transcription, initiation
AA956_RS08395	COG1595	DNA-templated transcription, initiation
AA956_RS08410	COG2860	membrane
AA956_RS08415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS08425	COG1538	Outer membrane efflux protein
AA956_RS08430	COG5002	protein histidine kinase activity
AA956_RS08435	COG2197	response regulator
AA956_RS08445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA956_RS08450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA956_RS08455	COG1845	cytochrome c oxidase, subunit III
AA956_RS08475	COG2070	2-Nitropropane dioxygenase
AA956_RS08485	COG1562	ergosterol biosynthetic process
AA956_RS08490	COG1562	ergosterol biosynthetic process
AA956_RS08495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AA956_RS08500	COG1657	PFAM Prenyltransferase squalene oxidase
AA956_RS08510	COG0463	Glycosyl transferase, family 2
AA956_RS08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA956_RS08540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA956_RS08550	COG0028	Belongs to the TPP enzyme family
AA956_RS08550	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AA956_RS08560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA956_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS08590	COG2375	cellular response to nickel ion
AA956_RS08595	COG1695	Transcriptional regulator
AA956_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS08630	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AA956_RS08635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA956_RS08640	COG1414	Transcriptional regulator
AA956_RS08655	COG0004	ammonium transporteR
AA956_RS08665	COG2186	Transcriptional regulator
AA956_RS08670	COG0277	FAD linked oxidase domain protein
AA956_RS08680	COG2814	Major facilitator Superfamily
AA956_RS08695	COG0579	oxidoreductase
AA956_RS08705	COG1414	Transcriptional regulator
AA956_RS08710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS08715	COG2271	Major facilitator Superfamily
AA956_RS08730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA956_RS08735	COG1960	acyl-CoA dehydrogenase activity
AA956_RS08740	COG1024	Enoyl-CoA hydratase
AA956_RS08745	COG0762	integral membrane protein
AA956_RS08765	COG4172	Belongs to the ABC transporter superfamily
AA956_RS08770	COG0747	negative chemotaxis
AA956_RS08780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA956_RS08805	COG3842	ATPase activity
AA956_RS08810	COG1653	transport
AA956_RS08815	COG1175	transmembrane transport
AA956_RS08825	COG0589	response to stress
AA956_RS08845	COG0534	Mate efflux family protein
AA956_RS08855	COG2985	domain, Protein
AA956_RS08860	COG2985	domain, Protein
AA956_RS08895	COG3383	formate dehydrogenase (NAD+) activity
AA956_RS08905	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AA956_RS08910	COG1802	Transcriptional regulator
AA956_RS08920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA956_RS08940	COG4191	Histidine kinase
AA956_RS08950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS08965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA956_RS08985	COG0583	DNA-binding transcription factor activity
AA956_RS09005	COG1802	Transcriptional regulator
AA956_RS09015	COG1024	Enoyl-CoA hydratase
AA956_RS09020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS09025	COG3387	PFAM Glycoside hydrolase 15-related
AA956_RS09050	COG3008	intermembrane lipid transfer
AA956_RS09055	COG2995	paraquat-inducible protein a
AA956_RS09065	COG3383	formate dehydrogenase (NAD+) activity
AA956_RS09065	COG0243	molybdopterin cofactor binding
AA956_RS09070	COG0243	molybdopterin cofactor binding
AA956_RS09070	COG3383	formate dehydrogenase (NAD+) activity
AA956_RS09075	COG0437	4 iron, 4 sulfur cluster binding
AA956_RS09080	COG2864	formate dehydrogenase
AA956_RS09095	COG3276	selenocysteine insertion sequence binding
AA956_RS09125	COG1802	Transcriptional regulator
AA956_RS09130	COG1301	dicarboxylic acid transport
AA956_RS09140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA956_RS09170	COG1104	cysteine desulfurase activity
AA956_RS09175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS09180	COG2368	4-hydroxyphenylacetate
AA956_RS09200	COG1137	ATPase activity
AA956_RS09220	COG1959	2 iron, 2 sulfur cluster binding
AA956_RS09230	COG2207	Transcriptional regulator
AA956_RS09235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS09245	COG1349	DNA-binding transcription factor activity
AA956_RS09250	COG1522	sequence-specific DNA binding
AA956_RS09275	COG2814	Major facilitator Superfamily
AA956_RS09320	COG2391	methyltransferase activity
AA956_RS09335	COG0823	Involved in the tonB-independent uptake of proteins
AA956_RS09345	COG0848	biopolymer transport protein
AA956_RS09355	COG0824	Thioesterase
AA956_RS09360	COG2084	Dehydrogenase
AA956_RS09365	COG1414	Transcriptional regulator
AA956_RS09410	COG2808	Putative FMN-binding domain
AA956_RS09445	COG0543	2 iron, 2 sulfur cluster binding
AA956_RS09450	COG2814	Major facilitator Superfamily
AA956_RS09495	COG2814	Major facilitator Superfamily
AA956_RS09500	COG0583	DNA-binding transcription factor activity
AA956_RS09525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA956_RS09535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS09540	COG0686	Belongs to the AlaDH PNT family
AA956_RS09545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS09580	COG0228	four-way junction DNA binding
AA956_RS09585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA956_RS09590	COG0336	Belongs to the RNA methyltransferase TrmD family
AA956_RS09595	COG0335	large ribosomal subunit rRNA binding
AA956_RS09600	COG0494	nUDIX hydrolase
AA956_RS09605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AA956_RS09610	COG1162	GTPase activity
AA956_RS09615	COG0501	Belongs to the peptidase M48B family
AA956_RS09620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AA956_RS09625	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA956_RS09635	COG0312	modulator of DNA gyrase
AA956_RS09665	COG3706	GGDEF domain
AA956_RS09665	COG5001	Diguanylate cyclase
AA956_RS09665	COG2203	Gaf domain
AA956_RS09665	COG4251	negative regulation of phosphorylation
AA956_RS09675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA956_RS09680	COG3842	ATPase activity
AA956_RS09685	COG1178	ABC-type Fe3 transport system permease component
AA956_RS09690	COG0583	DNA-binding transcription factor activity
AA956_RS09705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS09710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS09720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA956_RS09735	COG0415	Belongs to the DNA photolyase family
AA956_RS09745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA956_RS09765	COG2153	protein acetylation
AA956_RS09770	COG0488	(ABC) transporter
AA956_RS09785	COG1196	nuclear chromosome segregation
AA956_RS09785	COG0739	heme binding
AA956_RS09785	COG0741	lytic transglycosylase activity
AA956_RS09800	COG0583	DNA-binding transcription factor activity
AA956_RS09805	COG2814	Major facilitator Superfamily
AA956_RS09815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS09820	COG0697	spore germination
AA956_RS09855	COG4106	trans-aconitate 2-methyltransferase activity
AA956_RS09865	COG3135	benzoate transporter
AA956_RS09875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA956_RS09900	COG0778	Nitroreductase
AA956_RS09905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA956_RS09910	COG2878	Part of a membrane complex involved in electron transport
AA956_RS09915	COG1309	transcriptional regulator
AA956_RS09930	COG0556	nucleotide-excision repair
AA956_RS09935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS09940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA956_RS09955	COG1104	cysteine desulfurase activity
AA956_RS09960	COG0822	iron-sulfur transferase activity
AA956_RS09965	COG0316	Belongs to the HesB IscA family
AA956_RS09970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA956_RS10005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AA956_RS10015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AA956_RS10050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA956_RS10070	COG0084	hydrolase, TatD family'
AA956_RS10080	COG2267	carboxylic ester hydrolase activity
AA956_RS10085	COG0504	CTP synthase activity
AA956_RS10090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA956_RS10095	COG0148	phosphopyruvate hydratase activity
AA956_RS10100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AA956_RS10110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA956_RS10120	COG2833	Protein of unknown function (DUF455)
AA956_RS10125	COG2267	carboxylic ester hydrolase activity
AA956_RS10130	COG0613	PHP domain protein
AA956_RS10135	COG0009	L-threonylcarbamoyladenylate synthase
AA956_RS10140	COG1994	Peptidase M50
AA956_RS10145	COG0180	Tryptophanyl-tRNA synthetase
AA956_RS10150	COG2226	methyltransferase
AA956_RS10155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS10160	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AA956_RS10175	COG2850	peptidyl-arginine hydroxylation
AA956_RS10190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA956_RS10195	COG5001	Diguanylate cyclase
AA956_RS10195	COG3447	MASE1 domain protein
AA956_RS10195	COG5002	protein histidine kinase activity
AA956_RS10210	COG0149	triose-phosphate isomerase activity
AA956_RS10225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA956_RS10245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AA956_RS10255	COG1034	ATP synthesis coupled electron transport
AA956_RS10260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA956_RS10265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA956_RS10275	COG0713	ATP synthesis coupled electron transport
AA956_RS10290	COG1007	ATP synthesis coupled electron transport
AA956_RS10320	COG0625	glutathione transferase activity
AA956_RS10325	COG1960	acyl-CoA dehydrogenase activity
AA956_RS10340	COG1024	Enoyl-CoA hydratase
AA956_RS10345	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA956_RS10355	COG0625	glutathione transferase activity
AA956_RS10360	COG0436	Aminotransferase
AA956_RS10370	COG3022	response to hydroperoxide
AA956_RS10375	COG2866	Carboxypeptidase
AA956_RS10385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA956_RS10405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AA956_RS10415	COG0039	L-malate dehydrogenase activity
AA956_RS10420	COG2188	Transcriptional regulator
AA956_RS10435	COG1053	succinate dehydrogenase
AA956_RS10440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA956_RS10445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AA956_RS10450	COG0372	Belongs to the citrate synthase family
AA956_RS10455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA956_RS10465	COG0066	3-isopropylmalate dehydratase activity
AA956_RS10470	COG0473	3-isopropylmalate dehydrogenase activity
AA956_RS10475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA956_RS10485	COG0101	tRNA pseudouridine synthase activity
AA956_RS10490	COG0135	phosphoribosylanthranilate isomerase activity
AA956_RS10495	COG0133	tryptophan synthase activity
AA956_RS10505	COG0159	tryptophan synthase activity
AA956_RS10510	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA956_RS10515	COG0285	dihydrofolate synthase activity
AA956_RS10540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA956_RS10555	COG2194	sulfuric ester hydrolase activity
AA956_RS10560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA956_RS10560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA956_RS10565	COG3708	Transcriptional regulator
AA956_RS10565	COG2207	Transcriptional regulator
AA956_RS10570	COG0431	NADPH-dependent FMN reductase
AA956_RS10575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS10580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS10585	COG1116	anion transmembrane transporter activity
AA956_RS10595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA956_RS10600	COG0483	inositol monophosphate 1-phosphatase activity
AA956_RS10610	COG1045	serine acetyltransferase
AA956_RS10615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA956_RS10620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA956_RS10635	COG0215	cysteine-tRNA ligase activity
AA956_RS10640	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AA956_RS10645	COG0825	malonyl-CoA metabolic process
AA956_RS10650	COG0037	tRNA processing
AA956_RS10655	COG0527	aspartate kinase activity
AA956_RS10685	COG4174	ABC transporter (Permease)
AA956_RS10690	COG4239	(ABC) transporter, permease
AA956_RS10695	COG4172	Belongs to the ABC transporter superfamily
AA956_RS10700	COG0791	NLP P60 protein
AA956_RS10705	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA956_RS10710	COG1840	ABC-type Fe3 transport system, periplasmic component
AA956_RS10720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AA956_RS10735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA956_RS10745	COG2204	response regulator
AA956_RS10795	COG2197	response regulator
AA956_RS10800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS10815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS10820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA956_RS10855	COG0105	UTP biosynthetic process
AA956_RS10860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA956_RS10870	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA956_RS10875	COG0124	histidyl-tRNA synthetase
AA956_RS10880	COG2976	Protein conserved in bacteria
AA956_RS10890	COG1160	GTP binding
AA956_RS10895	COG1923	regulation of RNA biosynthetic process
AA956_RS10900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA956_RS10905	COG0330	HflC and HflK could
AA956_RS10910	COG0330	HflC and HflK could
AA956_RS10915	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AA956_RS10920	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA956_RS10930	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AA956_RS10940	COG0339	signal peptide processing
AA956_RS10945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA956_RS10950	COG4566	intracellular signal transduction
AA956_RS10960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AA956_RS10965	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA956_RS10975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA956_RS10985	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA956_RS10990	COG0697	spore germination
AA956_RS11005	COG1414	Transcriptional regulator
AA956_RS11020	COG1139	Iron-sulfur cluster binding protein
AA956_RS11025	COG0765	amino acid transport
AA956_RS11030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS11035	COG0167	dihydroorotate dehydrogenase activity
AA956_RS11040	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA956_RS11045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA956_RS11070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA956_RS11100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA956_RS11120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AA956_RS11135	COG0435	Glutathione S-transferase
AA956_RS11140	COG1278	Cold shock
AA956_RS11160	COG0679	Auxin Efflux Carrier
AA956_RS11205	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AA956_RS11210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AA956_RS11215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA956_RS11220	COG0840	transmembrane signaling receptor activity
AA956_RS11285	COG0174	glutamine synthetase
AA956_RS11295	COG2204	response regulator
AA956_RS11395	COG5532	Uncharacterized conserved protein (DUF2303)
AA956_RS11490	COG4197	protein conserved in bacteria, prophage-related
AA956_RS11520	COG1484	DNA-dependent DNA replication
AA956_RS11550	COG1396	sequence-specific DNA binding
AA956_RS11760	COG3344	reverse transcriptase
AA956_RS11770	COG0307	riboflavin synthase, alpha
AA956_RS11785	COG0387	Pfam Sodium calcium exchanger
AA956_RS11790	COG2186	Transcriptional regulator
AA956_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS11810	COG2818	Glycosylase
AA956_RS11815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AA956_RS11820	COG1187	pseudouridine synthase activity
AA956_RS11825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS11830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS11835	COG1116	anion transmembrane transporter activity
AA956_RS11850	COG2207	Transcriptional regulator
AA956_RS11860	COG0583	DNA-binding transcription factor activity
AA956_RS11865	COG0667	Aldo Keto reductase
AA956_RS11875	COG0557	exoribonuclease II activity
AA956_RS11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA956_RS11890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA956_RS11900	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AA956_RS11905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA956_RS11905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AA956_RS11910	COG1643	Atp-dependent helicase
AA956_RS11930	COG1058	Belongs to the CinA family
AA956_RS11930	COG1546	Belongs to the CinA family
AA956_RS11940	COG0583	DNA-binding transcription factor activity
AA956_RS11950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA956_RS11955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA956_RS11960	COG1187	pseudouridine synthase activity
AA956_RS11965	COG0779	Required for maturation of 30S ribosomal subunits
AA956_RS11970	COG2251	uridine kinase activity
AA956_RS11970	COG0195	Participates in both transcription termination and antitermination
AA956_RS11980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA956_RS11985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA956_RS11995	COG2814	Major facilitator Superfamily
AA956_RS12000	COG1566	PFAM secretion protein HlyD family protein
AA956_RS12035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA956_RS12040	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA956_RS12045	COG4208	sulfate ABC transporter
AA956_RS12050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA956_RS12055	COG0583	DNA-binding transcription factor activity
AA956_RS12060	COG0252	asparaginase activity
AA956_RS12065	COG2084	Dehydrogenase
AA956_RS12070	COG3622	Belongs to the hyi family
AA956_RS12075	COG3960	tartronate-semialdehyde synthase activity
AA956_RS12080	COG0583	DNA-binding transcription factor activity
AA956_RS12095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA956_RS12100	COG0359	binds to the 23S rRNA
AA956_RS12115	COG0306	phosphate transporter
AA956_RS12125	COG0791	NLP P60 protein
AA956_RS12130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AA956_RS12135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA956_RS12145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA956_RS12145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA956_RS12155	COG1215	transferase activity, transferring glycosyl groups
AA956_RS12160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA956_RS12165	COG2076	Multidrug Resistance protein
AA956_RS12170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA956_RS12180	COG0436	Aminotransferase
AA956_RS12200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AA956_RS12205	COG0314	molybdopterin synthase activity
AA956_RS12215	COG0542	response to heat
AA956_RS12225	COG3275	phosphorelay sensor kinase activity
AA956_RS12250	COG0697	spore germination
AA956_RS12255	COG2224	Isocitrate lyase
AA956_RS12265	COG0583	DNA-binding transcription factor activity
AA956_RS12275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA956_RS12285	COG0513	Belongs to the DEAD box helicase family
AA956_RS12290	COG1214	PFAM Peptidase M22, glycoprotease
AA956_RS12295	COG1214	PFAM Peptidase M22, glycoprotease
AA956_RS12295	COG0456	acetyltransferase
AA956_RS12300	COG1573	uracil-dna glycosylase
AA956_RS12310	COG0351	phosphomethylpyrimidine kinase
AA956_RS12315	COG0477	Major facilitator Superfamily
AA956_RS12320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA956_RS12330	COG0488	(ABC) transporter
AA956_RS12340	COG2890	protein-(glutamine-N5) methyltransferase activity
AA956_RS12345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA956_RS12350	COG1393	Belongs to the ArsC family
AA956_RS12355	COG2171	N-acyltransferase activity
AA956_RS12380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA956_RS12385	COG0242	peptide deformylase activity
AA956_RS12390	COG1187	pseudouridine synthase activity
AA956_RS12400	COG0024	Methionine aminopeptidase
AA956_RS12405	COG0052	Belongs to the universal ribosomal protein uS2 family
AA956_RS12410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA956_RS12425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA956_RS12435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA956_RS12440	COG0750	zinc metalloprotease
AA956_RS12455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA956_RS12480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA956_RS12485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AA956_RS12500	COG0330	HflC and HflK could
AA956_RS12515	COG2914	Belongs to the UPF0125 (RnfH) family
AA956_RS12535	COG0519	Catalyzes the synthesis of GMP from XMP
AA956_RS12535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA956_RS12540	COG2226	methyltransferase
AA956_RS12550	COG0583	DNA-binding transcription factor activity
AA956_RS12555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS12565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AA956_RS12570	COG0625	glutathione transferase activity
AA956_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS12600	COG1566	PFAM secretion protein HlyD family protein
AA956_RS12620	COG0583	DNA-binding transcription factor activity
AA956_RS12680	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA956_RS12690	COG3195	allantoin biosynthetic process
AA956_RS12690	COG3648	Uricase
AA956_RS12695	COG4266	Belongs to the allantoicase family
AA956_RS12705	COG2308	Evidence 4 Homologs of previously reported genes of
AA956_RS12740	COG2233	PERMEase
AA956_RS12750	COG0583	DNA-binding transcription factor activity
AA956_RS12755	COG3845	ABC transporter
AA956_RS12760	COG4603	Belongs to the binding-protein-dependent transport system permease family
AA956_RS12765	COG1079	Belongs to the binding-protein-dependent transport system permease family
AA956_RS12775	COG0488	(ABC) transporter
AA956_RS12800	COG3706	GGDEF domain
AA956_RS12815	COG0789	Transcriptional regulator
AA956_RS12840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA956_RS12865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA956_RS12905	COG0243	molybdopterin cofactor binding
AA956_RS12925	COG3383	formate dehydrogenase (NAD+) activity
AA956_RS12930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA956_RS12955	COG0733	neurotransmitter:sodium symporter activity
AA956_RS12970	COG0471	metal ion transport
AA956_RS12975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AA956_RS12980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA956_RS12985	COG1024	Enoyl-CoA hydratase
AA956_RS12995	COG3842	ATPase activity
AA956_RS13000	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA956_RS13015	COG3706	GGDEF domain
AA956_RS13035	COG2814	Major facilitator Superfamily
AA956_RS13050	COG5001	Diguanylate cyclase
AA956_RS13050	COG5002	protein histidine kinase activity
AA956_RS13085	COG2070	2-Nitropropane dioxygenase
AA956_RS13090	COG2070	2-Nitropropane dioxygenase
AA956_RS13130	COG3264	Mechanosensitive ion channel
AA956_RS13130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AA956_RS13150	COG2823	Periplasmic or secreted lipoprotein
AA956_RS13165	COG4572	Cation transport regulator
AA956_RS13170	COG2814	Major facilitator Superfamily
AA956_RS13175	COG0534	Mate efflux family protein
AA956_RS13185	COG3550	peptidyl-serine autophosphorylation
AA956_RS13220	COG1538	Outer membrane efflux protein
AA956_RS13270	COG0513	Belongs to the DEAD box helicase family
AA956_RS13290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS13295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS13320	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA956_RS13320	COG1902	pentaerythritol trinitrate reductase activity
AA956_RS13325	COG3706	GGDEF domain
AA956_RS13330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS13380	COG0798	PFAM Bile acid sodium symporter
AA956_RS13390	COG0640	Transcriptional regulator
AA956_RS13395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA956_RS13410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA956_RS13430	COG0625	glutathione transferase activity
AA956_RS13445	COG1802	Transcriptional regulator
AA956_RS13460	COG4774	siderophore transport
AA956_RS13465	COG4772	TonB-dependent receptor
AA956_RS13505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA956_RS13510	COG0583	DNA-binding transcription factor activity
AA956_RS13530	COG0411	ABC transporter
AA956_RS13580	COG1560	Kdo2-lipid A biosynthetic process
AA956_RS13585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AA956_RS13590	COG0165	Argininosuccinate lyase
AA956_RS13600	COG1473	amidohydrolase
AA956_RS13610	COG0583	DNA-binding transcription factor activity
AA956_RS13630	COG1914	H( )-stimulated, divalent metal cation uptake system
AA956_RS13640	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AA956_RS13645	COG1063	alcohol dehydrogenase
AA956_RS13665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA956_RS13675	COG0589	response to stress
AA956_RS13680	COG0589	response to stress
AA956_RS13690	COG3706	GGDEF domain
AA956_RS13695	COG2186	Transcriptional regulator
AA956_RS13715	COG0543	2 iron, 2 sulfur cluster binding
AA956_RS13735	COG2814	Major facilitator Superfamily
AA956_RS13740	COG0154	amidase activity
AA956_RS13750	COG0579	oxidoreductase
AA956_RS13755	COG0583	DNA-binding transcription factor activity
AA956_RS13770	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AA956_RS13780	COG0436	Aminotransferase
AA956_RS13785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS13820	COG1045	serine acetyltransferase
AA956_RS13830	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA956_RS13835	COG0583	DNA-binding transcription factor activity
AA956_RS13840	COG3493	citrate carrier protein
AA956_RS13850	COG2301	Belongs to the HpcH HpaI aldolase family
AA956_RS13875	COG0840	transmembrane signaling receptor activity
AA956_RS13880	COG0583	DNA-binding transcription factor activity
AA956_RS13885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA956_RS13905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS13950	COG3842	ATPase activity
AA956_RS13955	COG1840	ABC-type Fe3 transport system, periplasmic component
AA956_RS13960	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA956_RS13970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS13975	COG2188	Transcriptional regulator
AA956_RS13985	COG2986	histidine ammonia-lyase
AA956_RS13990	COG1113	amino acid transport
AA956_RS13995	COG1228	amidohydrolase
AA956_RS14000	COG0010	Belongs to the arginase family
AA956_RS14005	COG0583	DNA-binding transcription factor activity
AA956_RS14015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS14035	COG3791	Glutathione-dependent formaldehyde-activating
AA956_RS14045	COG2226	methyltransferase
AA956_RS14055	COG1113	amino acid transport
AA956_RS14065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS14070	COG0657	acetylesterase activity
AA956_RS14080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS14085	COG0346	lactoylglutathione lyase activity
AA956_RS14095	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA956_RS14100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA956_RS14120	COG2186	Transcriptional regulator
AA956_RS14140	COG3257	ureidoglycine aminohydrolase activity
AA956_RS14145	COG0583	DNA-binding transcription factor activity
AA956_RS14160	COG0402	S-adenosylhomocysteine deaminase activity
AA956_RS14165	COG2197	response regulator
AA956_RS14190	COG0583	DNA-binding transcription factor activity
AA956_RS14210	COG2814	Major facilitator Superfamily
AA956_RS14215	COG1022	Amp-dependent synthetase and ligase
AA956_RS14225	COG3246	L-lysine catabolic process to acetate
AA956_RS14230	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA956_RS14235	COG1024	Enoyl-CoA hydratase
AA956_RS14240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA956_RS14245	COG1595	DNA-templated transcription, initiation
AA956_RS14255	COG4774	siderophore transport
AA956_RS14260	COG2382	esterase
AA956_RS14280	COG5001	Diguanylate cyclase
AA956_RS14280	COG5002	protein histidine kinase activity
AA956_RS14280	COG3447	MASE1 domain protein
AA956_RS14295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA956_RS14300	COG0840	transmembrane signaling receptor activity
AA956_RS14345	COG4106	trans-aconitate 2-methyltransferase activity
AA956_RS14365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA956_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS14405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS14450	COG3842	ATPase activity
AA956_RS14480	COG0589	response to stress
AA956_RS14485	COG0667	Aldo Keto reductase
AA956_RS14560	COG4386	tail sheath protein
AA956_RS14580	COG4397	Mu-like prophage major head subunit gpT
AA956_RS14585	COG4388	Caudovirus prohead serine protease
AA956_RS14660	COG0739	heme binding
AA956_RS14660	COG1196	nuclear chromosome segregation
AA956_RS14660	COG0741	lytic transglycosylase activity
AA956_RS14685	COG4383	Mu-like prophage protein gp29
AA956_RS14715	COG0457	Tetratricopeptide repeat
AA956_RS14720	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AA956_RS14725	COG1215	transferase activity, transferring glycosyl groups
AA956_RS14790	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS14805	COG0628	permease
AA956_RS14815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA956_RS14825	COG2205	protein histidine kinase activity
AA956_RS14825	COG0784	Response regulator, receiver
AA956_RS14830	COG2197	response regulator
AA956_RS14835	COG0730	response to heat
AA956_RS14840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS14845	COG0598	Magnesium transport protein CorA
AA956_RS14850	COG0045	succinate-CoA ligase (ADP-forming) activity
AA956_RS14850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA956_RS14850	COG1042	CoA-binding domain protein
AA956_RS14855	COG0783	Belongs to the Dps family
AA956_RS14900	COG0765	amino acid transport
AA956_RS14910	COG0028	Belongs to the TPP enzyme family
AA956_RS14915	COG1522	sequence-specific DNA binding
AA956_RS14925	COG1272	protein, Hemolysin III
AA956_RS14930	COG0784	Response regulator, receiver
AA956_RS14930	COG2205	protein histidine kinase activity
AA956_RS14935	COG0840	transmembrane signaling receptor activity
AA956_RS14940	COG1254	Belongs to the acylphosphatase family
AA956_RS14945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA956_RS14955	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AA956_RS14970	COG0084	hydrolase, TatD family'
AA956_RS14980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA956_RS14985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA956_RS15005	COG2130	NADP-dependent
AA956_RS15015	COG1335	isochorismatase
AA956_RS15020	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA956_RS15020	COG1024	Enoyl-CoA hydratase
AA956_RS15030	COG0411	ABC transporter
AA956_RS15040	COG0559	Belongs to the binding-protein-dependent transport system permease family
AA956_RS15045	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS15050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA956_RS15055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA956_RS15065	COG2917	probably involved in intracellular septation
AA956_RS15075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA956_RS15080	COG0047	phosphoribosylformylglycinamidine synthase activity
AA956_RS15080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA956_RS15085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS15090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA956_RS15090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA956_RS15100	COG4181	ATPase activity
AA956_RS15110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA956_RS15130	COG0776	regulation of translation
AA956_RS15135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA956_RS15145	COG0740	serine-type endopeptidase activity
AA956_RS15150	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA956_RS15160	COG1960	acyl-CoA dehydrogenase activity
AA956_RS15165	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS15180	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS15190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA956_RS15200	COG0850	regulation of cytokinetic process
AA956_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS15220	COG0583	DNA-binding transcription factor activity
AA956_RS15235	COG2974	May be involved in recombination
AA956_RS15245	COG1132	(ABC) transporter
AA956_RS15250	COG0189	ligase activity
AA956_RS15250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA956_RS15255	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA956_RS15255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA956_RS15270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA956_RS15280	COG0583	DNA-binding transcription factor activity
AA956_RS15285	COG0657	acetylesterase activity
AA956_RS15290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS15325	COG0024	Methionine aminopeptidase
AA956_RS15350	COG1278	Cold shock
AA956_RS15370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA956_RS15555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA956_RS15560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA956_RS15575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA956_RS15580	COG0387	Pfam Sodium calcium exchanger
AA956_RS15585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA956_RS15590	COG0148	phosphopyruvate hydratase activity
AA956_RS15605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA956_RS15625	COG0537	adenosine 5'-monophosphoramidase activity
AA956_RS15635	COG0038	chloride channel
AA956_RS15650	COG4774	siderophore transport
AA956_RS15715	COG0450	alkyl hydroperoxide reductase
AA956_RS15720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA956_RS15725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA956_RS15730	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA956_RS15735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AA956_RS15765	COG4977	sequence-specific DNA binding
AA956_RS15770	COG0560	Phosphoserine phosphatase
AA956_RS15775	COG0626	cystathionine gamma-synthase activity
AA956_RS15780	COG0183	Belongs to the thiolase family
AA956_RS15785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA956_RS15790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA956_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS15805	COG0183	Belongs to the thiolase family
AA956_RS15810	COG3243	poly(R)-hydroxyalkanoic acid synthase
AA956_RS15820	COG0564	pseudouridine synthase activity
AA956_RS15830	COG0505	Belongs to the CarA family
AA956_RS15835	COG1199	ATP-dependent helicase activity
AA956_RS15850	COG2183	response to ionizing radiation
AA956_RS15855	COG3158	transport of potassium into the cell
AA956_RS15905	COG4964	Belongs to the GSP D family
AA956_RS15950	COG1846	Transcriptional regulator
AA956_RS15980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AA956_RS15985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA956_RS15990	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA956_RS15995	COG0567	Dehydrogenase, E1 component
AA956_RS16000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA956_RS16005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA956_RS16015	COG0840	transmembrane signaling receptor activity
AA956_RS16025	COG1280	lysine exporter protein (LysE YggA)
AA956_RS16055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA956_RS16080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA956_RS16100	COG3706	GGDEF domain
AA956_RS16100	COG5001	Diguanylate cyclase
AA956_RS16100	COG4251	negative regulation of phosphorylation
AA956_RS16100	COG2203	Gaf domain
AA956_RS16120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS16135	COG1177	transmembrane transport
AA956_RS16140	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA956_RS16145	COG3842	ATPase activity
AA956_RS16165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS16170	COG3706	GGDEF domain
AA956_RS16180	COG2501	S4 domain
AA956_RS16185	COG2199	diguanylate cyclase activity
AA956_RS16185	COG2200	EAL domain
AA956_RS16185	COG2202	Pas domain
AA956_RS16210	COG1773	rubredoxin
AA956_RS16235	COG0776	regulation of translation
AA956_RS16250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA956_RS16260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA956_RS16265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA956_RS16275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA956_RS16280	COG0251	oxidation-reduction process
AA956_RS16290	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS16305	COG2197	response regulator
AA956_RS16315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA956_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS16340	COG0477	Major facilitator Superfamily
AA956_RS16355	COG2267	carboxylic ester hydrolase activity
AA956_RS16365	COG1295	ribonuclease BN
AA956_RS16380	COG0277	FAD linked oxidase domain protein
AA956_RS16410	COG0254	rRNA binding
AA956_RS16420	COG0534	Mate efflux family protein
AA956_RS16430	COG0583	DNA-binding transcription factor activity
AA956_RS16460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA956_RS16465	COG0683	leucine binding
AA956_RS16475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA956_RS16480	COG1652	LysM domain
AA956_RS16485	COG1183	phosphatidylcholine synthase activity
AA956_RS16490	COG0688	phosphatidylethanolamine metabolic process
AA956_RS16495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA956_RS16505	COG0028	Belongs to the TPP enzyme family
AA956_RS16510	COG1595	DNA-templated transcription, initiation
AA956_RS16540	COG0438	transferase activity, transferring glycosyl groups
AA956_RS16550	COG1309	transcriptional regulator
AA956_RS16570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA956_RS16585	COG2346	COG2346, Truncated hemoglobins
AA956_RS16590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA956_RS16605	COG0745	RESPONSE REGULATOR receiver
AA956_RS16610	COG2205	protein histidine kinase activity
AA956_RS16615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA956_RS16620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA956_RS16625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA956_RS16635	COG0583	DNA-binding transcription factor activity
AA956_RS16660	COG3118	belongs to the thioredoxin family
AA956_RS16670	COG1741	Belongs to the pirin family
AA956_RS16680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA956_RS16695	COG1561	YicC-like family, N-terminal region
AA956_RS16705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA956_RS16710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA956_RS16715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA956_RS16725	COG2801	Transposase and inactivated derivatives
AA956_RS16740	COG2963	transposase activity
AA956_RS16745	COG2801	Transposase and inactivated derivatives
AA956_RS16770	COG3976	FMN-binding domain protein
AA956_RS16770	COG1053	succinate dehydrogenase
AA956_RS16880	COG1021	2,3-dihydroxybenzoate-AMP ligase
AA956_RS16950	COG3706	GGDEF domain
AA956_RS16985	COG3842	ATPase activity
AA956_RS16995	COG0583	DNA-binding transcription factor activity
AA956_RS17010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AA956_RS17025	COG3038	cytochrome b561
AA956_RS17045	COG2223	nitrite transmembrane transporter activity
AA956_RS17060	COG1271	oxidase subunit
AA956_RS17065	COG1294	oxidase, subunit
AA956_RS17075	COG0302	gtp cyclohydrolase
AA956_RS17085	COG1131	(ABC) transporter
AA956_RS17090	COG0842	Transport permease protein
AA956_RS17100	COG0583	DNA-binding transcription factor activity
AA956_RS17115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA956_RS17135	COG1929	Belongs to the glycerate kinase type-1 family
AA956_RS17180	COG0583	DNA-binding transcription factor activity
AA956_RS17185	COG2271	Major facilitator Superfamily
AA956_RS17195	COG0129	dihydroxy-acid dehydratase activity
AA956_RS17200	COG2084	Dehydrogenase
AA956_RS17205	COG0747	negative chemotaxis
AA956_RS17225	COG2814	Major facilitator Superfamily
AA956_RS17230	COG2814	Major facilitator Superfamily
AA956_RS17245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AA956_RS17255	COG0583	DNA-binding transcription factor activity
AA956_RS17260	COG0427	acetyl-CoA hydrolase
AA956_RS17265	COG0840	transmembrane signaling receptor activity
AA956_RS17275	COG0840	transmembrane signaling receptor activity
AA956_RS17285	COG0252	asparaginase activity
AA956_RS17295	COG0583	DNA-binding transcription factor activity
AA956_RS17300	COG2957	Belongs to the agmatine deiminase family
AA956_RS17305	COG0697	spore germination
AA956_RS17310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS17320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA956_RS17335	COG1610	YqeY-like protein
AA956_RS17340	COG2081	HI0933 family
AA956_RS17345	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA956_RS17350	COG1469	GTP cyclohydrolase I activity
AA956_RS17355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA956_RS17360	COG0142	geranyltranstransferase activity
AA956_RS17365	COG1722	exodeoxyribonuclease VII activity
AA956_RS17390	COG0412	Dienelactone hydrolase
AA956_RS17395	COG1252	NADH dehydrogenase
AA956_RS17405	COG1611	Belongs to the LOG family
AA956_RS17410	COG2391	methyltransferase activity
AA956_RS17420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA956_RS17430	COG0210	DNA helicase
AA956_RS17435	COG0525	valine-tRNA ligase activity
AA956_RS17445	COG0425	Belongs to the sulfur carrier protein TusA family
AA956_RS17465	COG1942	4-Oxalocrotonate Tautomerase
AA956_RS17470	COG0235	Class ii aldolase
AA956_RS17475	COG0477	Major facilitator Superfamily
AA956_RS17480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA956_RS17485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA956_RS17500	COG1335	isochorismatase
AA956_RS17515	COG0066	3-isopropylmalate dehydratase activity
AA956_RS17520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA956_RS17550	COG2188	Transcriptional regulator
AA956_RS17555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS17560	COG0583	DNA-binding transcription factor activity
AA956_RS17570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA956_RS17580	COG1733	regulation of RNA biosynthetic process
AA956_RS17625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AA956_RS17630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS17650	COG1595	DNA-templated transcription, initiation
AA956_RS17685	COG2062	phosphohistidine phosphatase, SixA
AA956_RS17700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA956_RS17710	COG0745	RESPONSE REGULATOR receiver
AA956_RS17720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA956_RS17725	COG0581	inorganic phosphate transmembrane transporter activity
AA956_RS17730	COG0573	inorganic phosphate transmembrane transporter activity
AA956_RS17735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA956_RS17750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA956_RS17760	COG1534	Rna-binding protein
AA956_RS17770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA956_RS17775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA956_RS17785	COG0505	Belongs to the CarA family
AA956_RS17805	COG1301	dicarboxylic acid transport
AA956_RS17810	COG4266	Belongs to the allantoicase family
AA956_RS17835	COG1960	acyl-CoA dehydrogenase activity
AA956_RS17840	COG1024	Enoyl-CoA hydratase
AA956_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS17865	COG0583	DNA-binding transcription factor activity
AA956_RS17880	COG0741	lytic transglycosylase activity
AA956_RS17880	COG1388	LysM domain
AA956_RS17885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA956_RS17895	COG0328	RNA-DNA hybrid ribonuclease activity
AA956_RS17920	COG2271	Major facilitator Superfamily
AA956_RS17930	COG2814	Major facilitator Superfamily
AA956_RS17935	COG1283	sodium-dependent phosphate transmembrane transporter activity
AA956_RS17955	COG2252	PERMEase
AA956_RS17980	COG0513	Belongs to the DEAD box helicase family
AA956_RS17995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS18020	COG2233	PERMEase
AA956_RS18025	COG0587	DNA-directed DNA polymerase activity
AA956_RS18040	COG1914	H( )-stimulated, divalent metal cation uptake system
AA956_RS18065	COG0789	Transcriptional regulator
AA956_RS18070	COG3568	Endonuclease Exonuclease Phosphatase
AA956_RS18080	COG2608	mercury ion transmembrane transporter activity
AA956_RS18085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA956_RS18095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA956_RS18095	COG4651	solute:proton antiporter activity
AA956_RS18110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AA956_RS18125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA956_RS18135	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA956_RS18140	COG2252	PERMEase
AA956_RS18145	COG0402	S-adenosylhomocysteine deaminase activity
AA956_RS18150	COG2119	membrane
AA956_RS18160	COG0308	aminopeptidase N
AA956_RS18175	COG0583	DNA-binding transcription factor activity
AA956_RS18180	COG4106	trans-aconitate 2-methyltransferase activity
AA956_RS18185	COG2271	Major facilitator Superfamily
AA956_RS18190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA956_RS18210	COG0540	Belongs to the ATCase OTCase family
AA956_RS18235	COG1017	nitric oxide dioxygenase activity
AA956_RS18235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA956_RS18240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA956_RS18245	COG3842	ATPase activity
AA956_RS18255	COG4208	sulfate ABC transporter
AA956_RS18285	COG1917	Cupin 2, conserved barrel domain protein
AA956_RS18330	COG0583	DNA-binding transcription factor activity
AA956_RS18360	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS18375	COG0583	DNA-binding transcription factor activity
AA956_RS18380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS18395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA956_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS18405	COG0604	alcohol dehydrogenase
AA956_RS18405	COG3321	synthase
AA956_RS18410	COG0583	DNA-binding transcription factor activity
AA956_RS18425	COG0693	protein deglycase activity
AA956_RS18445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA956_RS18475	COG1305	Transglutaminase-like
AA956_RS18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA956_RS18485	COG0583	DNA-binding transcription factor activity
AA956_RS18520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AA956_RS18525	COG1845	cytochrome c oxidase, subunit III
AA956_RS18535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA956_RS18540	COG1280	lysine exporter protein (LysE YggA)
AA956_RS18545	COG1522	sequence-specific DNA binding
AA956_RS18555	COG0583	DNA-binding transcription factor activity
AA956_RS18570	COG1742	UPF0060 membrane protein
AA956_RS18575	COG2900	Belongs to the SlyX family
AA956_RS18585	COG1764	response to oxidative stress
AA956_RS18605	COG0129	dihydroxy-acid dehydratase activity
AA956_RS18630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA956_RS18635	COG2271	Major facilitator Superfamily
AA956_RS18640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS18645	COG1522	sequence-specific DNA binding
AA956_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS18660	COG0583	DNA-binding transcription factor activity
AA956_RS18680	COG1131	(ABC) transporter
AA956_RS18685	COG0842	Transport permease protein
AA956_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS18770	COG0277	FAD linked oxidase domain protein
AA956_RS18770	COG0247	lactate metabolic process
AA956_RS18775	COG2271	Major facilitator Superfamily
AA956_RS18780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA956_RS18785	COG1802	Transcriptional regulator
AA956_RS18795	COG1414	Transcriptional regulator
AA956_RS18800	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS18830	COG1454	alcohol dehydrogenase
AA956_RS18845	COG2897	thiosulfate sulfurtransferase activity
AA956_RS18855	COG1960	acyl-CoA dehydrogenase activity
AA956_RS18860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS18870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS18880	COG1116	anion transmembrane transporter activity
AA956_RS18910	COG0154	amidase activity
AA956_RS18925	COG0583	DNA-binding transcription factor activity
AA956_RS18935	COG1304	FMN binding
AA956_RS18940	COG1522	sequence-specific DNA binding
AA956_RS18945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS18950	COG1113	amino acid transport
AA956_RS18955	COG1309	transcriptional regulator
AA956_RS18985	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS18990	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AA956_RS18995	COG2982	Protein involved in outer membrane biogenesis
AA956_RS19000	COG0259	pyridoxamine-phosphate oxidase activity
AA956_RS19005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA956_RS19015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA956_RS19020	COG0477	Major facilitator Superfamily
AA956_RS19035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA956_RS19040	COG0010	Belongs to the arginase family
AA956_RS19045	COG1126	abc transporter atp-binding protein
AA956_RS19050	COG0765	amino acid transport
AA956_RS19055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS19080	COG2309	aminopeptidase activity
AA956_RS19085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA956_RS19100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA956_RS19110	COG3483	tryptophan 2,3-dioxygenase activity
AA956_RS19120	COG1960	acyl-CoA dehydrogenase activity
AA956_RS19125	COG0450	alkyl hydroperoxide reductase
AA956_RS19130	COG4575	ribosome binding
AA956_RS19170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS19180	COG1309	transcriptional regulator
AA956_RS19185	COG0725	ABC transporter, periplasmic molybdate-binding protein
AA956_RS19190	COG4149	molybdate abc transporter
AA956_RS19195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AA956_RS19205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA956_RS19210	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AA956_RS19225	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA956_RS19225	COG3608	succinylglutamate desuccinylase aspartoacylase
AA956_RS19235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA956_RS19245	COG0642	Histidine kinase
AA956_RS19255	COG2027	D-alanyl-D-alanine carboxypeptidase
AA956_RS19265	COG0009	L-threonylcarbamoyladenylate synthase
AA956_RS19270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA956_RS19275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AA956_RS19280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA956_RS19300	COG0469	pyruvate kinase activity
AA956_RS19305	COG0126	phosphoglycerate kinase activity
AA956_RS19335	COG0429	hydrolase of the alpha beta-hydrolase fold
AA956_RS19355	COG0315	cyclic pyranopterin monophosphate synthase activity
AA956_RS19360	COG0697	spore germination
AA956_RS19365	COG1846	Transcriptional regulator
AA956_RS19375	COG0583	DNA-binding transcription factor activity
AA956_RS19380	COG0459	protein refolding
AA956_RS19515	COG3040	lipid binding
AA956_RS19525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA956_RS19540	COG0459	protein refolding
AA956_RS19560	COG0071	Belongs to the small heat shock protein (HSP20) family
AA956_RS19575	COG2205	protein histidine kinase activity
AA956_RS19580	COG0745	RESPONSE REGULATOR receiver
AA956_RS19585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA956_RS19590	COG0785	Cytochrome C biogenesis protein
AA956_RS19590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA956_RS19595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA956_RS19610	COG2010	Cytochrome c
AA956_RS19640	COG0596	Alpha beta hydrolase
AA956_RS19655	COG1802	Transcriptional regulator
AA956_RS19665	COG3706	GGDEF domain
AA956_RS19680	COG1199	ATP-dependent helicase activity
AA956_RS19680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA956_RS19690	COG2072	flavoprotein involved in K transport
AA956_RS19695	COG0601	transmembrane transport
AA956_RS19700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA956_RS19705	COG0444	Belongs to the ABC transporter superfamily
AA956_RS19710	COG4608	Belongs to the ABC transporter superfamily
AA956_RS19715	COG0747	negative chemotaxis
AA956_RS19765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA956_RS19770	COG1988	membrane-bound metal-dependent
AA956_RS19790	COG0673	inositol 2-dehydrogenase activity
AA956_RS19805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS19810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS19815	COG1309	transcriptional regulator
AA956_RS19840	COG2824	Alkylphosphonate utilization operon protein PhnA
AA956_RS19850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA956_RS19855	COG3707	response regulator
AA956_RS19865	COG0243	molybdopterin cofactor binding
AA956_RS19875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA956_RS19880	COG0477	Major facilitator Superfamily
AA956_RS19885	COG1960	acyl-CoA dehydrogenase activity
AA956_RS19890	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS19900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AA956_RS19905	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS19910	COG1846	Transcriptional regulator
AA956_RS19945	COG2197	response regulator
AA956_RS19950	COG0583	DNA-binding transcription factor activity
AA956_RS19975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS20015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA956_RS20025	COG0436	Aminotransferase
AA956_RS20055	COG0183	Belongs to the thiolase family
AA956_RS20060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AA956_RS20070	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS20080	COG0477	Major facilitator Superfamily
AA956_RS20085	COG1454	alcohol dehydrogenase
AA956_RS20090	COG1802	Transcriptional regulator
AA956_RS20095	COG0583	DNA-binding transcription factor activity
AA956_RS20100	COG3284	Transcriptional regulator
AA956_RS20105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS20110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA956_RS20125	COG1803	Methylglyoxal synthase
AA956_RS20130	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS20135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA956_RS20145	COG0433	COG0433 Predicted ATPase
AA956_RS20150	COG0217	transcriptional regulatory protein
AA956_RS20155	COG0151	Belongs to the GarS family
AA956_RS20160	COG0668	transmembrane transport
AA956_RS20175	COG0799	negative regulation of ribosome biogenesis
AA956_RS20180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA956_RS20185	COG1653	transport
AA956_RS20190	COG1175	transmembrane transport
AA956_RS20195	COG0395	ABC-type sugar transport system, permease component
AA956_RS20205	COG0584	glycerophosphoryl diester phosphodiesterase
AA956_RS20210	COG0424	maF-like protein
AA956_RS20215	COG1530	ribonuclease E activity
AA956_RS20220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AA956_RS20270	COG1054	Belongs to the UPF0176 family
AA956_RS20275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA956_RS20280	COG0513	Belongs to the DEAD box helicase family
AA956_RS20290	COG0583	DNA-binding transcription factor activity
AA956_RS20300	COG0655	NAD(P)H dehydrogenase (quinone) activity
AA956_RS20315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA956_RS20325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA956_RS20335	COG1253	flavin adenine dinucleotide binding
AA956_RS20340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA956_RS20345	COG1074	ATP-dependent DNA helicase activity
AA956_RS20350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AA956_RS20355	COG1289	transmembrane transporter activity
AA956_RS20360	COG2197	response regulator
AA956_RS20370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS20375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA956_RS20380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS20400	COG2916	Histone family protein nucleoid-structuring protein H-NS
AA956_RS20410	COG0477	Major facilitator Superfamily
AA956_RS20425	COG0640	Transcriptional regulator
AA956_RS20435	COG0583	DNA-binding transcription factor activity
AA956_RS20450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS20455	COG0765	amino acid transport
AA956_RS20460	COG0765	amino acid transport
AA956_RS20465	COG0280	phosphate acetyltransferase
AA956_RS20465	COG0281	malic enzyme
AA956_RS20510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS20530	COG0543	2 iron, 2 sulfur cluster binding
AA956_RS20530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA956_RS20535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA956_RS20555	COG0411	ABC transporter
AA956_RS20575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA956_RS20580	COG1047	Peptidyl-prolyl cis-trans
AA956_RS20585	COG2003	Belongs to the UPF0758 family
AA956_RS20595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA956_RS20600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA956_RS20610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA956_RS20620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AA956_RS20620	COG3264	Mechanosensitive ion channel
AA956_RS20625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA956_RS20625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA956_RS20630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA956_RS20635	COG0196	riboflavin kinase activity
AA956_RS20640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA956_RS20645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA956_RS20650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA956_RS20655	COG2814	Major facilitator Superfamily
AA956_RS20660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA956_RS20670	COG0542	response to heat
AA956_RS20675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA956_RS20680	COG1278	Cold shock
AA956_RS20715	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS20720	COG0583	DNA-binding transcription factor activity
AA956_RS20765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA956_RS20770	COG1570	exodeoxyribonuclease VII activity
AA956_RS20775	COG0811	peptide transport
AA956_RS20790	COG2835	tetraacyldisaccharide 4'-kinase activity
AA956_RS20795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AA956_RS20800	COG0563	adenylate kinase activity
AA956_RS20815	COG2912	Transglutaminase-like superfamily
AA956_RS20820	COG0728	peptidoglycan biosynthetic process
AA956_RS20825	COG0268	Binds directly to 16S ribosomal RNA
AA956_RS20840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA956_RS20845	COG3123	guanosine phosphorylase activity
AA956_RS20860	COG1666	GTP binding
AA956_RS20865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA956_RS20870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA956_RS20875	COG0318	PFAM AMP-dependent synthetase and ligase
AA956_RS20880	COG4974	Belongs to the 'phage' integrase family
AA956_RS20885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA956_RS20890	COG0802	atpase or kinase
AA956_RS20895	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA956_RS20900	COG0586	Pfam SNARE associated Golgi protein
AA956_RS20905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA956_RS20910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA956_RS20930	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA956_RS20935	COG0006	proline dipeptidase activity
AA956_RS20940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA956_RS20950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA956_RS20955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA956_RS20965	COG0617	tRNA 3'-terminal CCA addition
AA956_RS20970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA956_RS20975	COG1428	Deoxynucleoside kinase
AA956_RS20985	COG0642	Histidine kinase
AA956_RS21000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA956_RS21010	COG0641	radical SAM
AA956_RS21035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA956_RS21035	COG0512	Glutamine amidotransferase of anthranilate synthase
AA956_RS21045	COG0443	Heat shock 70 kDa protein
AA956_RS21055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA956_RS21070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA956_RS21090	COG0497	DNA recombination
AA956_RS21095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA956_RS21105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA956_RS21110	COG0312	modulator of DNA gyrase
AA956_RS21115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA956_RS21120	COG2096	Adenosyltransferase
AA956_RS21125	COG0277	FAD linked oxidase domain protein
AA956_RS21130	COG0277	FAD linked oxidase domain protein
AA956_RS21135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA956_RS21140	COG0277	FAD linked oxidase domain protein
AA956_RS21145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS21155	COG0386	Belongs to the glutathione peroxidase family
AA956_RS21170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA956_RS21180	COG0672	)-iron permease
AA956_RS21185	COG4633	Protein conserved in bacteria
AA956_RS21200	COG0765	amino acid transport
AA956_RS21205	COG0765	amino acid transport
AA956_RS21210	COG1126	abc transporter atp-binding protein
AA956_RS21235	COG3038	cytochrome b561
AA956_RS21265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA956_RS21295	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AA956_RS21305	COG2721	sulfolactate sulfo-lyase activity
AA956_RS21340	COG1335	isochorismatase
AA956_RS21345	COG0583	DNA-binding transcription factor activity
AA956_RS21375	COG3842	ATPase activity
AA956_RS21385	COG4948	Mandelate Racemase Muconate Lactonizing
AA956_RS21390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS21395	COG2188	Transcriptional regulator
AA956_RS21435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA956_RS21440	COG0322	excinuclease ABC activity
AA956_RS21460	COG0736	holo-[acyl-carrier-protein] synthase activity
AA956_RS21465	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA956_RS21475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA956_RS21480	COG0571	ribonuclease III activity
AA956_RS21485	COG0681	Belongs to the peptidase S26 family
AA956_RS21505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA956_RS21525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA956_RS21530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA956_RS21535	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS21545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA956_RS21550	COG0416	fatty acid biosynthetic process
AA956_RS21555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA956_RS21560	COG1399	metal-binding, possibly nucleic acid-binding protein
AA956_RS21570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA956_RS21575	COG0616	signal peptide processing
AA956_RS21575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA956_RS21585	COG0546	phosphoglycolate phosphatase activity
AA956_RS21590	COG0564	pseudouridine synthase activity
AA956_RS21595	COG1530	ribonuclease E activity
AA956_RS21600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA956_RS21610	COG0746	molybdenum cofactor guanylyltransferase activity
AA956_RS21615	COG0303	'Molybdopterin
AA956_RS21645	COG1556	Lactate utilization protein
AA956_RS21650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA956_RS21655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA956_RS21680	COG0277	FAD linked oxidase domain protein
AA956_RS21685	COG0277	FAD linked oxidase domain protein
AA956_RS21690	COG0247	lactate metabolic process
AA956_RS21700	COG3384	dioxygenase
AA956_RS21705	COG0583	DNA-binding transcription factor activity
AA956_RS21710	COG1253	flavin adenine dinucleotide binding
AA956_RS21720	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AA956_RS21725	COG1280	lysine exporter protein (LysE YggA)
AA956_RS21730	COG1278	Cold shock
AA956_RS21735	COG4942	peptidase
AA956_RS21740	COG2943	transferase activity, transferring hexosyl groups
AA956_RS21740	COG3416	Protein conserved in bacteria
AA956_RS21745	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AA956_RS21750	COG1280	lysine exporter protein (LysE YggA)
AA956_RS21760	COG0534	Mate efflux family protein
AA956_RS21770	COG2807	transmembrane transport
AA956_RS21780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA956_RS21795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA956_RS21805	COG2205	protein histidine kinase activity
AA956_RS21805	COG0784	Response regulator, receiver
AA956_RS21805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA956_RS21805	COG2198	Histidine kinase
AA956_RS21835	COG2855	membrane
AA956_RS21850	COG2885	chlorophyll binding
AA956_RS21885	COG0531	amino acid
AA956_RS21915	COG2031	fatty acid transporter
AA956_RS21940	COG3781	membrane
AA956_RS21975	COG2814	Major facilitator Superfamily
AA956_RS21980	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AA956_RS22015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AA956_RS22020	COG1846	Transcriptional regulator
AA956_RS22030	COG0405	Gamma-glutamyltransferase
AA956_RS22040	COG1278	Cold shock
AA956_RS22055	COG0582	viral genome integration into host DNA
AA956_RS22115	COG2003	Belongs to the UPF0758 family
AA956_RS22190	COG3621	Patatin-like phospholipase
AA956_RS22365	COG1192	Involved in chromosome partitioning
AA956_RS22380	COG0583	DNA-binding transcription factor activity
AA956_RS22400	COG0071	Belongs to the small heat shock protein (HSP20) family
AA956_RS22405	COG0542	response to heat
AA956_RS22415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA956_RS22460	COG0501	Belongs to the peptidase M48B family
AA956_RS22465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA956_RS22470	COG0583	DNA-binding transcription factor activity
AA956_RS22480	COG2814	Major facilitator Superfamily
AA956_RS22505	COG2814	Major facilitator Superfamily
AA956_RS22520	COG1968	undecaprenyl-diphosphatase activity
AA956_RS22545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA956_RS22585	COG0438	transferase activity, transferring glycosyl groups
AA956_RS22590	COG0438	transferase activity, transferring glycosyl groups
AA956_RS22595	COG0438	transferase activity, transferring glycosyl groups
AA956_RS22600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA956_RS22605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA956_RS22610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA956_RS22625	COG0540	Belongs to the ATCase OTCase family
AA956_RS22630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA956_RS22635	COG1678	Uncharacterized ACR, COG1678
AA956_RS22645	COG1773	rubredoxin
AA956_RS22660	COG4969	Belongs to the N-Me-Phe pilin family
AA956_RS22665	COG0861	Integral membrane protein TerC family
AA956_RS22670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AA956_RS22675	COG0045	succinate-CoA ligase (ADP-forming) activity
AA956_RS22685	COG2137	regulation of response to DNA damage stimulus
AA956_RS22690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA956_RS22700	COG0642	Histidine kinase
AA956_RS22705	COG0477	Major facilitator Superfamily
AA956_RS22725	COG0861	Integral membrane protein TerC family
AA956_RS22730	COG0583	DNA-binding transcription factor activity
AA956_RS22735	COG0628	permease
AA956_RS22750	COG1116	anion transmembrane transporter activity
AA956_RS22760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA956_RS22765	COG0156	8-amino-7-oxononanoate synthase activity
AA956_RS22770	COG1396	sequence-specific DNA binding
AA956_RS22775	COG0840	transmembrane signaling receptor activity
AA956_RS22790	COG1902	pentaerythritol trinitrate reductase activity
AA956_RS22795	COG0668	transmembrane transport
AA956_RS22820	COG3706	GGDEF domain
AA956_RS22830	COG2719	SpoVR family
AA956_RS22835	COG2718	Belongs to the UPF0229 family
AA956_RS22840	COG2766	serine protein kinase
AA956_RS22845	COG1121	(ABC) transporter
AA956_RS22855	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA956_RS22860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA956_RS22865	COG1702	phosphate starvation-inducible protein PhoH
AA956_RS22870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA956_RS22875	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AA956_RS22885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA956_RS22890	COG0752	glycyl-tRNA synthetase alpha subunit
AA956_RS22895	COG0751	glycine-tRNA ligase activity
AA956_RS22900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA956_RS22905	COG0204	Acyl-transferase
AA956_RS22915	COG0346	lactoylglutathione lyase activity
AA956_RS22920	COG1773	rubredoxin
AA956_RS22935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA956_RS22940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA956_RS22960	COG0006	proline dipeptidase activity
AA956_RS22965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS22975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AA956_RS22980	COG0138	bifunctional purine biosynthesis protein purh
AA956_RS22985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS22990	COG3608	succinylglutamate desuccinylase aspartoacylase
AA956_RS22990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA956_RS23005	COG2207	Transcriptional regulator
AA956_RS23015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA956_RS23030	COG0495	leucyl-tRNA aminoacylation
AA956_RS23040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA956_RS23045	COG0735	belongs to the Fur family
AA956_RS23055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA956_RS23060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AA956_RS23065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA956_RS23075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA956_RS23090	COG4290	ribonuclease
AA956_RS23095	COG0281	malic enzyme
AA956_RS23095	COG0280	phosphate acetyltransferase
AA956_RS23105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AA956_RS23110	COG1058	Belongs to the CinA family
AA956_RS23110	COG1546	Belongs to the CinA family
AA956_RS23115	COG0284	orotidine-5'-phosphate decarboxylase activity
AA956_RS23125	COG0668	transmembrane transport
AA956_RS23130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA956_RS23135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA956_RS23150	COG0557	exoribonuclease II activity
AA956_RS23155	COG3150	esterase
AA956_RS23160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA956_RS23170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA956_RS23175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA956_RS23180	COG0511	ligase activity, forming carbon-carbon bonds
AA956_RS23185	COG0439	Biotin carboxylase
AA956_RS23215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA956_RS23215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA956_RS23230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA956_RS23260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA956_RS23265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA956_RS23270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AA956_RS23275	COG2095	MarC family integral membrane protein
AA956_RS23280	COG0442	prolyl-tRNA aminoacylation
AA956_RS23300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA956_RS23305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA956_RS23310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA956_RS23315	COG0142	geranyltranstransferase activity
AA956_RS23325	COG4536	flavin adenine dinucleotide binding
AA956_RS23350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AA956_RS23355	COG0494	nUDIX hydrolase
AA956_RS23365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA956_RS23370	COG0653	protein targeting
AA956_RS23380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA956_RS23395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AA956_RS23400	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA956_RS23405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA956_RS23410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA956_RS23420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA956_RS23430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA956_RS23435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA956_RS23445	COG3116	cell division
AA956_RS23450	COG0275	rRNA processing
AA956_RS23465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AA956_RS23480	COG0243	molybdopterin cofactor binding
AA956_RS23485	COG1473	amidohydrolase
AA956_RS23525	COG1024	Enoyl-CoA hydratase
AA956_RS23535	COG0183	Belongs to the thiolase family
AA956_RS23540	COG1024	Enoyl-CoA hydratase
AA956_RS23545	COG2050	protein possibly involved in aromatic compounds catabolism
AA956_RS23555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AA956_RS23565	COG2967	ApaG domain
AA956_RS23570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA956_RS23575	COG0546	phosphoglycolate phosphatase activity
AA956_RS23590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA956_RS23595	COG1129	ABC transporter
AA956_RS23595	COG0842	Transport permease protein
AA956_RS23600	COG0842	Transport permease protein
AA956_RS23610	COG0642	Histidine kinase
AA956_RS23620	COG4232	protein-disulfide reductase activity
AA956_RS23625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA956_RS23640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA956_RS23645	COG0134	indole-3-glycerol-phosphate synthase activity
AA956_RS23655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA956_RS23660	COG4774	siderophore transport
AA956_RS23675	COG0583	DNA-binding transcription factor activity
AA956_RS23690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA956_RS23695	COG2321	neutral zinc metallopeptidase
AA956_RS23700	COG0012	GTP binding
AA956_RS23725	COG0463	Glycosyl transferase, family 2
AA956_RS23740	COG0477	Major facilitator Superfamily
AA956_RS23750	COG2261	transglycosylase associated protein
AA956_RS23755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA956_RS23760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA956_RS23765	COG2890	protein-(glutamine-N5) methyltransferase activity
AA956_RS23770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA956_RS23775	COG0163	prenyltransferase activity
AA956_RS23800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA956_RS23805	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AA956_RS23810	COG0835	chemotaxis
AA956_RS23820	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS23825	COG0488	(ABC) transporter
AA956_RS23840	COG1408	metallophosphoesterase
AA956_RS23845	COG1254	Belongs to the acylphosphatase family
AA956_RS23855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA956_RS23870	COG2271	Major facilitator Superfamily
AA956_RS23880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA956_RS23955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA956_RS23960	COG1696	Membrane protein involved in D-alanine export
AA956_RS23980	COG1215	transferase activity, transferring glycosyl groups
AA956_RS23990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AA956_RS24030	COG3045	CreA protein
AA956_RS24035	COG3284	Transcriptional regulator
AA956_RS24045	COG1454	alcohol dehydrogenase
AA956_RS24110	COG1473	amidohydrolase
AA956_RS24130	COG0210	DNA helicase
AA956_RS24140	COG2969	positive regulation of protein catabolic process
AA956_RS24145	COG0625	glutathione transferase activity
AA956_RS24150	COG2857	Cytochrome c1
AA956_RS24155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA956_RS24160	COG0723	plastoquinol--plastocyanin reductase activity
AA956_RS24170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA956_RS24175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA956_RS24180	COG0805	protein transport
AA956_RS24190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA956_RS24210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA956_RS24220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA956_RS24225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA956_RS24230	COG2095	MarC family integral membrane protein
AA956_RS24250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA956_RS24260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA956_RS24270	COG0842	Transport permease protein
AA956_RS24275	COG1131	(ABC) transporter
AA956_RS24295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA956_RS24300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA956_RS24305	COG1127	ABC transporter
AA956_RS24315	COG0352	thiamine-phosphate diphosphorylase activity
AA956_RS24335	COG4178	(ABC) transporter
AA956_RS24340	COG1028	Short-chain dehydrogenase reductase Sdr
AA956_RS24345	COG2814	Major facilitator Superfamily
AA956_RS24355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA956_RS24360	COG2271	Major facilitator Superfamily
AA956_RS24370	COG0070	glutamate synthase
AA956_RS24370	COG0069	glutamate synthase activity
AA956_RS24370	COG0067	glutamate synthase
AA956_RS24380	COG3047	cAMP biosynthetic process
AA956_RS24385	COG3047	cAMP biosynthetic process
AA956_RS24395	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AA956_RS24400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA956_RS24430	COG1965	Belongs to the frataxin family
AA956_RS24435	COG0019	diaminopimelate decarboxylase activity
AA956_RS24440	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AA956_RS24445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA956_RS24450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA956_RS24455	COG1333	cytochrome c biogenesis protein
AA956_RS24465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA956_RS24475	COG4232	protein-disulfide reductase activity
AA956_RS24485	COG0203	ribosomal protein L17
AA956_RS24490	COG0202	RNA polymerase activity
AA956_RS24495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA956_RS24500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA956_RS24505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA956_RS24510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA956_RS24515	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA956_RS24520	COG0201	protein transport
AA956_RS24525	COG0200	Binds to the 23S rRNA
AA956_RS24540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA956_RS24545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA956_RS24555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA956_RS24560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA956_RS24565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA956_RS24570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA956_RS24575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA956_RS24580	COG0255	Belongs to the universal ribosomal protein uL29 family
AA956_RS24590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA956_RS24595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA956_RS24600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA956_RS24605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA956_RS24610	COG0089	rRNA binding
AA956_RS24615	COG0088	Forms part of the polypeptide exit tunnel
AA956_RS24620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA956_RS24625	COG0051	transcription antitermination factor activity, RNA binding
AA956_RS24630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA956_RS24640	COG0049	tRNA binding
AA956_RS24645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA956_RS24650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA956_RS24665	COG2207	Transcriptional regulator
AA956_RS24695	COG0583	DNA-binding transcription factor activity
AA956_RS24700	COG1448	Aminotransferase
AA956_RS24710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA956_RS24715	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA956_RS24725	COG1012	belongs to the aldehyde dehydrogenase family
AA956_RS24735	COG3971	2-oxopent-4-enoate hydratase activity
AA956_RS24740	COG4772	TonB-dependent receptor
AA956_RS24745	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AA956_RS24745	COG0662	Cupin 2, conserved barrel domain protein
AA956_RS24760	COG0222	ribosome binding
AA956_RS24765	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA956_RS24775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA956_RS24785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA956_RS24850	COG2771	luxR family
AA956_RS24880	COG0741	lytic transglycosylase activity
AA956_RS25060	COG1674	ftsk spoiiie
AA956_RS25085	COG0739	heme binding
AA956_RS25125	COG0475	glutathione-regulated potassium exporter activity