locus-tag class description PI93_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) PI93_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) PI93_RS00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PI93_RS00065 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) PI93_RS00090 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) PI93_RS00105 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein PI93_RS00115 ENOG4105CSP Major Facilitator Superfamily PI93_RS00120 ENOG4105CSH Transporter PI93_RS00125 ENOG4108M0I Transcriptional regulator PI93_RS00135 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) PI93_RS00165 ENOG4107RSM transcriptional regulator PI93_RS00175 ENOG4105C26 Dehydrogenase PI93_RS00195 ENOG4105DDW LysR family Transcriptional regulator PI93_RS00210 ENOG4108IQI permease PI93_RS00220 ENOG4105MWK D-amino acid dehydrogenase, small subunit PI93_RS00225 ENOG4105WBV Transcriptional regulator PI93_RS00230 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) PI93_RS00235 ENOG4105CPU Monooxygenase PI93_RS00240 ENOG4105DUM transcriptional regulator, lysR family PI93_RS00245 ENOG4105CSH Transporter PI93_RS00250 ENOG4105D82 Glutamate dehydrogenase PI93_RS00260 ENOG4108JU7 Transcriptional regulator PI93_RS00270 ENOG4105CSH Transporter PI93_RS00275 ENOG4105EW6 flavin reductase domain protein, FMN-binding PI93_RS00280 ENOG4107XBN GntR Family Transcriptional Regulator PI93_RS00300 ENOG4108IV0 ABC, transporter PI93_RS00305 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) PI93_RS00330 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS00350 ENOG41061MD high-affinity nickel-transporter PI93_RS00355 ENOG4105JQZ Methyltransferase PI93_RS00365 ENOG4107NQ8 LysR family Transcriptional regulator PI93_RS00375 ENOG4105E5Q amino acid AbC transporter PI93_RS00380 ENOG4105DRP amino acid AbC transporter PI93_RS00415 ENOG4105CEP NADH dehydrogenase PI93_RS00420 ENOG4108X07 Tetr family transcriptional regulator PI93_RS00435 ENOG4105E0K tonB-dependent siderophore receptor PI93_RS00440 ENOG4108S3W Anti-feci sigma factor, fecr PI93_RS00450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PI93_RS00470 ENOG4108QM7 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) PI93_RS00475 ENOG4105DUM transcriptional regulator, lysR family PI93_RS00480 ENOG4105C0A alcohol dehydrogenase PI93_RS00505 ENOG4105C7N Xanthine uracil vitamin C permease PI93_RS00510 ENOG4105DND Transcriptional regulator PI93_RS00525 ENOG4106BRA Membrane PI93_RS00530 ENOG4107QP3 malate synthase g PI93_RS00535 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) PI93_RS00570 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS00585 ENOG4105HEI LysR family (Transcriptional regulator PI93_RS00590 ENOG4105F27 Major Facilitator PI93_RS00595 ENOG4105F4R Transcriptional regulator mode PI93_RS00600 ENOG4105BZU Histidine kinase PI93_RS00605 ENOG4105EU0 Major facilitator Superfamily PI93_RS00630 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) PI93_RS00640 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS00650 ENOG4108KTQ Methyltransferase PI93_RS00655 ENOG4108V3W Chemotaxis protein, CheW PI93_RS00660 ENOG4105CBS Chea signal transduction histidine kinase PI93_RS00665 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) PI93_RS00705 ENOG4105CH2 amidohydrolase PI93_RS00710 ENOG4105CSH Transporter PI93_RS00720 ENOG4105CE7 Amidase, hydantoinase carbamoylase family PI93_RS00725 ENOG4108IV0 ABC, transporter PI93_RS00730 ENOG4105C0Z ABC transporter PI93_RS00740 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS00750 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS00760 ENOG4107SM8 Adenylate Guanylate cyclase PI93_RS00765 ENOG4105GVF (ABC) transporter PI93_RS00770 ENOG4108ESX Receptor PI93_RS00775 ENOG4107E2E PKHD-type hydroxylase PI93_RS00805 ENOG4105C5I Dehydrogenase PI93_RS00810 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) PI93_RS00830 ENOG4105D22 carbon starvation protein PI93_RS00835 ENOG4105VCD cytoplasmic protein PI93_RS00840 ENOG4105D4P Coproporphyrinogen iii oxidase PI93_RS00845 ENOG4105CC0 LysR family Transcriptional regulator PI93_RS00850 ENOG4105C9U ATP-dependent DNA helicase RecQ PI93_RS00865 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PI93_RS00875 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) PI93_RS00880 ENOG4105D0M Protease HtpX homolog PI93_RS00885 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B PI93_RS00895 ENOG4105ES5 Histidine kinase PI93_RS00900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PI93_RS00900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PI93_RS00940 ENOG4105CNI cell division protein FtsW PI93_RS00945 ENOG4105CJN penicillin-binding protein PI93_RS00955 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) PI93_RS00960 ENOG4105DFF Rod shape-determining protein mreb PI93_RS00965 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PI93_RS00980 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) PI93_RS00985 ENOG4105CSR polyphosphate kinase 2 PI93_RS01025 ENOG4107QHF type ii secretion system protein e PI93_RS01035 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) PI93_RS01045 ENOG4105CSU acyl-Coa dehydrogenase PI93_RS01050 ENOG4107RGH Aldehyde dehydrogenase PI93_RS01060 ENOG4105D1S lipid A biosynthesis PI93_RS01065 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) PI93_RS01075 ENOG4108J6E Pfam:Phage_integr_N PI93_RS01080 ENOG4105DR4 Methyltransferase PI93_RS01085 ENOG410814C multidrug resistance protein PI93_RS01095 ENOG4105CKI cobalamin synthesis protein PI93_RS01100 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters PI93_RS01110 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) PI93_RS01115 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) PI93_RS01120 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) PI93_RS01125 ENOG4108UYB regulatoR PI93_RS01145 ENOG4105CAS nag kinase PI93_RS01160 ENOG4105FP9 thiamine pyrophosphate PI93_RS01170 ENOG4105CSH Transporter PI93_RS01185 ENOG4105FDP GntR family transcriptional regulator PI93_RS01205 ENOG4105CAD extracellular ligand-binding receptor PI93_RS01220 ENOG4105C0Z ABC transporter PI93_RS01225 ENOG4108IV0 ABC, transporter PI93_RS01235 ENOG4105JSC dimethylmenaquinone methyltransferase PI93_RS01255 ENOG4108Z9W Outer membrane porin PI93_RS01260 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS01270 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) PI93_RS01275 ENOG4105DWV Homoserine O-trans-acetylase PI93_RS01280 ENOG4105DWV Homoserine O-trans-acetylase PI93_RS01285 ENOG4105EYM Major Facilitator superfamily PI93_RS01295 ENOG4105CGK Exodeoxyribonuclease III PI93_RS01300 ENOG4105CMU LysR family (Transcriptional regulator PI93_RS01310 ENOG41067MG lrgb family PI93_RS01315 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) PI93_RS01320 ENOG41082T9 Membrane PI93_RS01325 ENOG4105DX0 Hemolysin A PI93_RS01330 ENOG4105SYT Methylenetetrahydrofolate reductase PI93_RS01335 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS01340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PI93_RS01345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS01350 ENOG4105C3U ABC transporter PI93_RS01355 ENOG4108JQ7 (ABC) transporter PI93_RS01365 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) PI93_RS01370 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) PI93_RS01380 ENOG4105CQM Urea amidohydrolase subunit alpha PI93_RS01385 ENOG4105KI2 Urea amidohydrolase subunit beta PI93_RS01395 ENOG4108YZ9 Urea amidohydrolase subunit gamma PI93_RS01400 ENOG4105CDA abc transporter atp-binding protein PI93_RS01405 ENOG4105E5Q amino acid AbC transporter PI93_RS01410 ENOG4105DRP amino acid AbC transporter PI93_RS01425 ENOG4108IV0 ABC, transporter PI93_RS01430 ENOG4105C0Z ABC transporter PI93_RS01440 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS01450 ENOG4105DXI Major Facilitator superfamily PI93_RS01460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS01465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) PI93_RS01470 ENOG4105E7W lamb ycsf family protein PI93_RS01475 ENOG4107R7A Allophanate hydrolase subunit 2 PI93_RS01480 ENOG4105P4J Allophanate hydrolase, subunit 1 PI93_RS01490 ENOG4107SC1 transglycosylase PI93_RS01500 ENOG4108RXX maleylacetoacetate isomerase PI93_RS01505 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate PI93_RS01515 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS01545 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) PI93_RS01550 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) PI93_RS01555 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain PI93_RS01560 ENOG4108Z9W Outer membrane porin PI93_RS01570 ENOG4105C3J Cysteine desulfurase PI93_RS01575 ENOG4105CH6 catalase PI93_RS01620 ENOG4105CDH Citrulline--aspartate ligase PI93_RS01625 ENOG4105CC0 LysR family Transcriptional regulator PI93_RS01645 ENOG4105EJC lysr family transcriptional regulator PI93_RS01675 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase PI93_RS01690 ENOG4105EJC lysr family transcriptional regulator PI93_RS01705 ENOG4105CF1 Alkylated DNA repair protein PI93_RS01715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) PI93_RS01730 ENOG4105CKI cobalamin synthesis protein PI93_RS01745 ENOG4105JAB phenazine biosynthesis protein, phzf family PI93_RS01750 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein PI93_RS01760 ENOG4105E3B Multicopper oxidase PI93_RS01795 ENOG4108Z9W Outer membrane porin PI93_RS01800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase PI93_RS01860 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase PI93_RS01865 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase PI93_RS01870 ENOG4108VWS Yaeq family PI93_RS01890 ENOG410631K Membrane PI93_RS01905 ENOG4108Z9W Outer membrane porin PI93_RS01910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS01925 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) PI93_RS01930 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) PI93_RS01935 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) PI93_RS01945 ENOG4108UKI Enoyl-CoA hydratase PI93_RS01950 ENOG4107QX3 carboxylase PI93_RS01955 ENOG4105K5B UPF0225 protein PI93_RS01965 ENOG4107FW0 short-chain dehydrogenase reductase PI93_RS01970 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS01975 ENOG41077A9 carbonic anhydrase PI93_RS01980 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) PI93_RS01985 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS01995 ENOG4108Z6Z Transcriptional regulator PI93_RS02005 ENOG4105CSH Transporter PI93_RS02030 ENOG4105C75 arginyL-tRNA synthetase PI93_RS02050 ENOG4105C3R Methionine synthase PI93_RS02055 ENOG4105C3R Methionine synthase PI93_RS02070 ENOG4105F2Z 3-oxoadipate enol-lactonase PI93_RS02095 ENOG4108UKI Enoyl-CoA hydratase PI93_RS02135 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) PI93_RS02155 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase PI93_RS02165 ENOG4105DHJ ABC, transporter PI93_RS02185 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS02200 ENOG4105DZ1 carboxypeptidase PI93_RS02205 ENOG4105F0I Aminotransferase PI93_RS02210 ENOG4108Z43 UPF0250 protein PI93_RS02230 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) PI93_RS02245 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region PI93_RS02255 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS02265 ENOG4105CK2 sodium dicarboxylate symporter PI93_RS02295 ENOG4105C0P Mg chelatase subunit ChlI PI93_RS02300 ENOG4105W0Z cytoplasmic protein PI93_RS02310 ENOG4108YZA Nitrogen regulatory protein pii PI93_RS02315 ENOG4105BZU Histidine kinase PI93_RS02330 ENOG4105D7Z glutathione synthase PI93_RS02340 ENOG41080Z8 PHOSPHOCARRIER protein PI93_RS02345 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) PI93_RS02350 ENOG4105D06 uba thif-type nad fad binding protein PI93_RS02355 ENOG4105CN1 protease PI93_RS02365 ENOG4107YZP Rhodanese domain protein PI93_RS02370 ENOG4105VW4 glutaredoxin 3 PI93_RS02375 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) PI93_RS02385 ENOG4108UVJ appr-1-p processing domain protein PI93_RS02400 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) PI93_RS02410 ENOG4105CIF Ornithine Cyclodeaminase PI93_RS02415 ENOG4106PA8 Plays an important role in the de novo pathway of purine nucleotide biosynthesis PI93_RS02425 ENOG4105DBV ornithine carbamoyltransferase PI93_RS02430 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) PI93_RS02440 ENOG4107XC4 flavin reductase domain protein, FMN-binding PI93_RS02455 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) PI93_RS02460 ENOG4105BZ9 Cytochrome C oxidase, subunit I PI93_RS02465 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) PI93_RS02475 ENOG4107QS1 Cytochrome C Oxidase, Subunit III PI93_RS02495 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) PI93_RS02505 ENOG4108ZX6 Electron transport protein SCO1 SenC PI93_RS02515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii PI93_RS02520 ENOG4105C4M (Ubiquinol oxidase) subunit I PI93_RS02530 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PI93_RS02540 ENOG4108MTB glycosyl transferase family PI93_RS02545 ENOG4108RXX maleylacetoacetate isomerase PI93_RS02550 ENOG4108ZUB Lysine exporter protein (Lyse ygga) PI93_RS02575 ENOG4105CJ1 ABC, transporter PI93_RS02580 ENOG4106H78 methyltransferase PI93_RS02585 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) PI93_RS02590 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding PI93_RS02595 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) PI93_RS02605 ENOG4105C5T Phosphoribosyl pyrophosphate synthase PI93_RS02620 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) PI93_RS02635 ENOG4105CEN a g-specific adenine glycosylase PI93_RS02640 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) PI93_RS02650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) PI93_RS02655 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN PI93_RS02660 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA PI93_RS02665 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PI93_RS02670 ENOG4108IUZ ABC transporter PI93_RS02685 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase PI93_RS02690 ENOG4105C2X Arabinose 5-phosphate isomerase PI93_RS02700 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) PI93_RS02710 ENOG4105E98 transcriptional regulator DeoR family PI93_RS02715 ENOG4105D5T phosphonate abc transporter PI93_RS02720 ENOG4105EHI Phosphonate ABC transporter, periplasmic PI93_RS02730 ENOG4105FD8 phosphonate metabolism protein PhnM PI93_RS02735 ENOG4105HRV phosphonate c-p lyase system protein phnl PI93_RS02740 ENOG4105ENV phosphonate C-P lyase system protein PhnK PI93_RS02745 ENOG4105FT8 Phosphonate metabolism PI93_RS02750 ENOG4105EKV Phosphonate metabolism protein PI93_RS02765 ENOG4107RJJ Transcriptional regulator PI93_RS02770 ENOG4108TXN phosphonate metabolism protein PI93_RS02795 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS02810 ENOG4107STF Involved in phosphonate degradation (By similarity) PI93_RS02815 ENOG4107RCV ABC transporter, permease PI93_RS02825 ENOG4105C4Y ABC transporter PI93_RS02845 ENOG4105EAM Na Pi-cotransporter PI93_RS02865 ENOG4105KME endoribonuclease L-psp PI93_RS02875 ENOG4108SGR YheO domain-containing protein PI93_RS02885 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) PI93_RS02890 ENOG4107RDB Major Facilitator PI93_RS02920 ENOG4107R0W ABC transporter PI93_RS02925 ENOG4105DRP amino acid AbC transporter PI93_RS02935 ENOG4105EST Metal Dependent Phosphohydrolase PI93_RS02940 ENOG4105J0Q Transcriptional regulator PI93_RS02945 ENOG4105CE7 Amidase, hydantoinase carbamoylase family PI93_RS02950 ENOG4107RCH Diaminopropionate ammonia-lyase PI93_RS02955 ENOG4105CH2 amidohydrolase PI93_RS02960 ENOG4108PVQ transcriptional regulator PI93_RS02970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS02975 ENOG4105C26 Dehydrogenase PI93_RS02985 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS03005 ENOG4108SHQ Glutathione S-transferase PI93_RS03030 ENOG4105D2S major facilitator superfamily PI93_RS03035 ENOG4108Z9W Outer membrane porin PI93_RS03040 ENOG4105CPC Aldo Keto reductase PI93_RS03045 ENOG4105CF7 AraC family transcriptional regulator PI93_RS03050 ENOG4105DQE DNA ligase PI93_RS03055 ENOG4105FDF Could be involved in DNA repair (By similarity) PI93_RS03070 ENOG4105C5I Dehydrogenase PI93_RS03080 ENOG4105MSY salicylate hydroxylase PI93_RS03085 ENOG4108RXX maleylacetoacetate isomerase PI93_RS03105 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) PI93_RS03115 ENOG4105CSH Transporter PI93_RS03120 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase PI93_RS03130 ENOG4108JQ6 ABC transporter PI93_RS03135 ENOG4105CHR reductase PI93_RS03140 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS03145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS03150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PI93_RS03195 ENOG4105E5Q amino acid AbC transporter PI93_RS03200 ENOG4105CYW agmatinase PI93_RS03205 ENOG4105CDA abc transporter atp-binding protein PI93_RS03210 ENOG4105KME endoribonuclease L-psp PI93_RS03220 ENOG4108UW5 maltose o-acetyltransferase PI93_RS03250 ENOG4105CMJ mandelate racemase muconate lactonizing PI93_RS03255 ENOG4105E1F short-chain dehydrogenase reductase PI93_RS03260 ENOG4105CF7 AraC family transcriptional regulator PI93_RS03270 ENOG4105CSH Transporter PI93_RS03295 ENOG4105MWK D-amino acid dehydrogenase, small subunit PI93_RS03300 ENOG4105CV8 reductase PI93_RS03305 ENOG4105CPW cytochrome b561 PI93_RS03310 ENOG4105D05 Receptor PI93_RS03325 ENOG4108JQC penicillin-binding protein 1A PI93_RS03330 ENOG4105C5Q Transcriptional regulator PI93_RS03350 ENOG4105CYM Glutathione S-transferase PI93_RS03360 ENOG4105CGF Aromatic amino acid aminotransferase PI93_RS03365 ENOG4105C85 amino acid PI93_RS03375 ENOG4105J0Q Transcriptional regulator PI93_RS03380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) PI93_RS03385 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS03390 ENOG4107QNJ CoA-transferase subunit B PI93_RS03400 ENOG4107HP6 Transcriptional regulator PI93_RS03410 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase PI93_RS03430 ENOG4105D6F Phosphatase PI93_RS03435 ENOG4108Z9W Outer membrane porin PI93_RS03445 ENOG4105D2S major facilitator superfamily PI93_RS03460 ENOG4105CNV Aldolase PI93_RS03465 ENOG4107RSM transcriptional regulator PI93_RS03485 ENOG4105D2S major facilitator superfamily PI93_RS03495 ENOG4107QK4 glycoside hydrolase, family 3 domain protein PI93_RS03500 ENOG4105EJC lysr family transcriptional regulator PI93_RS03505 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) PI93_RS03510 ENOG4105CPU Monooxygenase PI93_RS03520 ENOG4105DND Transcriptional regulator PI93_RS03525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PI93_RS03530 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B PI93_RS03535 ENOG4108Z9W Outer membrane porin PI93_RS03540 ENOG4105CSH Transporter PI93_RS03570 ENOG4108FUF Transcriptional regulator, IclR family PI93_RS03575 ENOG4108FUF Transcriptional regulator, IclR family PI93_RS03590 ENOG4105P69 integral membrane protein PI93_RS03595 ENOG4108E94 phosphate acetyltransferase PI93_RS03620 ENOG4105E1V na solute symporter PI93_RS03625 ENOG4105CI2 imidazolone-5-propionate hydrolase PI93_RS03635 ENOG4105C85 amino acid PI93_RS03640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS03645 ENOG4108IY8 ABC, transporter PI93_RS03650 ENOG4106FTQ Taurine ABC transporter, periplasmic PI93_RS03655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS03660 ENOG4108TGY Glutathione S-transferase PI93_RS03670 ENOG4108WFR AraC Family Transcriptional Regulator PI93_RS03690 ENOG4105EXG Transcriptional regulator PI93_RS03695 ENOG4105C26 Dehydrogenase PI93_RS03710 ENOG4107RCH Diaminopropionate ammonia-lyase PI93_RS03715 ENOG4105CE7 Amidase, hydantoinase carbamoylase family PI93_RS03725 ENOG4105CSP Major Facilitator Superfamily PI93_RS03730 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PI93_RS03740 ENOG4105DZ2 Transcriptional regulator PI93_RS03745 ENOG4105WPN DNA integration recombination invertion protein PI93_RS03755 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) PI93_RS03760 ENOG4105MXW flavin reductase domain protein, FMN-binding PI93_RS03780 ENOG4105YVS arsR family transcriptional regulator PI93_RS03825 ENOG4105BZU Histidine kinase PI93_RS03835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) PI93_RS03845 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS03860 ENOG4106KNT transcriptional regulator PI93_RS03870 ENOG4105KME endoribonuclease L-psp PI93_RS03890 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) PI93_RS03900 ENOG4105C7B Threonine dehydratase PI93_RS03910 ENOG4105W39 Membrane PI93_RS03930 ENOG4105EEQ Na H antiporter PI93_RS03945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PI93_RS03960 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) PI93_RS03965 ENOG4105FQ6 thiopurine methyltransferase PI93_RS03985 ENOG4105C9M aspartyl-trna synthetase PI93_RS03990 ENOG4108TIT dATP pyrophosphohydrolase PI93_RS03995 ENOG4105DZQ phospholipase D Transphosphatidylase PI93_RS04005 ENOG4105CSU acyl-Coa dehydrogenase PI93_RS04015 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS04025 ENOG4105NAU thioesterase Superfamily protein PI93_RS04030 ENOG4108JJ7 ABC transporter PI93_RS04040 ENOG4105D82 Glutamate dehydrogenase PI93_RS04045 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS04050 ENOG4105EAD ABC transporter PI93_RS04055 ENOG4105DRP amino acid AbC transporter PI93_RS04060 ENOG4105CDA abc transporter atp-binding protein PI93_RS04065 ENOG4105E7A Glutamine amidotransferase PI93_RS04070 ENOG4105EKE dihydroorotase PI93_RS04090 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) PI93_RS04095 ENOG4108UJD 30S ribosomal protein S9 PI93_RS04100 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase PI93_RS04105 ENOG4108YX9 iron--sulfur cluster insertion protein erpA PI93_RS04110 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) PI93_RS04115 ENOG4105DR5 peptidase PI93_RS04130 ENOG4108V1U phospholipid-binding protein PI93_RS04135 ENOG4105CVJ phosphoglycerate mutase PI93_RS04145 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) PI93_RS04150 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) PI93_RS04155 ENOG4108YXA Membrane PI93_RS04175 ENOG4105C01 Dihydroxy-acid dehydratase PI93_RS04180 ENOG4108UHU Aldolase PI93_RS04185 ENOG4105C6Z Gluconate PI93_RS04190 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family PI93_RS04195 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) PI93_RS04210 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PI93_RS04215 ENOG4105W8H transhydrogenase (subunit alpha PI93_RS04220 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PI93_RS04230 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) PI93_RS04235 ENOG4105CBC glutamate synthase PI93_RS04305 ENOG4105WH1 Two component transcriptional regulator luxr family PI93_RS04340 ENOG4108HHI Type III secretion system protein PI93_RS04350 ENOG4108TN6 type iii secretion PI93_RS04355 ENOG4108IUF type iii secretion PI93_RS04360 ENOG4105E4C Lytic transglycosylase catalytic PI93_RS04370 ENOG4107QTF adenylosuccinate lyase PI93_RS04375 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) PI93_RS04380 ENOG4105T86 cytochrome C PI93_RS04390 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) PI93_RS04395 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) PI93_RS04400 ENOG4105VIE preprotein translocase, subunit YajC PI93_RS04405 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) PI93_RS04415 ENOG4105CB5 ATP-dependent DNA helicase recG PI93_RS04420 ENOG4105C5Q Transcriptional regulator PI93_RS04425 ENOG4105CH6 catalase PI93_RS04430 ENOG4108UB3 Thiamine monophosphate PI93_RS04445 ENOG4108ZJF Glcg protein PI93_RS04450 ENOG4107F3C Hemin uptake protein PI93_RS04465 ENOG4105EUB pirin domain protein PI93_RS04490 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) PI93_RS04495 ENOG4108UQY Iron-storage protein PI93_RS04505 ENOG4108TEB UPF0114 protein PI93_RS04515 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) PI93_RS04525 ENOG4107QN1 sodium solute PI93_RS04550 ENOG4105GVR general secretion pathway protein D PI93_RS04555 ENOG4105MQ5 zona occludens toxin PI93_RS04610 ENOG4105F3H Histidine kinase PI93_RS04660 ENOG4105E0F Histidine kinase PI93_RS04680 ENOG4107S8C mandelate racemase muconate lactonizing PI93_RS04710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PI93_RS04725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS04730 ENOG4105F38 ABC transporter, permease PI93_RS04735 ENOG4105F38 ABC transporter, permease PI93_RS04740 ENOG4105CTU Proline racemase PI93_RS04760 ENOG410642W LysR family Transcriptional regulator PI93_RS04775 ENOG4105E02 MotA TolQ exbB proton channel PI93_RS04780 ENOG4105M8F Biopolymer transport protein exbD tolR PI93_RS04880 ENOG4105PM1 preprotein translocase subunit SecE PI93_RS04890 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) PI93_RS04900 ENOG4108VZM 50s ribosomal protein L10 PI93_RS04905 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) PI93_RS04915 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PI93_RS04920 ENOG4105GAV receptor PI93_RS04935 ENOG4105C26 Dehydrogenase PI93_RS04945 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS04950 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) PI93_RS04965 ENOG4105CSH Transporter PI93_RS04970 ENOG4105CGF Aromatic amino acid aminotransferase PI93_RS04975 ENOG4105F04 LysR family Transcriptional regulator PI93_RS04980 ENOG4106AS2 Outer membrane autotransporter PI93_RS05010 ENOG4105R1U AraC Family Transcriptional Regulator PI93_RS05025 ENOG4107SQD Transcriptional regulator, GntR family PI93_RS05030 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) PI93_RS05035 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) PI93_RS05040 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) PI93_RS05045 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) PI93_RS05050 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) PI93_RS05055 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) PI93_RS05060 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) PI93_RS05065 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) PI93_RS05070 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity PI93_RS05075 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) PI93_RS05080 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) PI93_RS05085 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) PI93_RS05090 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) PI93_RS05095 ENOG41084PQ 50s ribosomal protein l29 PI93_RS05100 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal PI93_RS05105 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) PI93_RS05110 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) PI93_RS05115 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits PI93_RS05120 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) PI93_RS05130 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) PI93_RS05135 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) PI93_RS05140 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) PI93_RS05155 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) PI93_RS05160 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) PI93_RS05165 ENOG41067V7 50S ribosomal protein L36 PI93_RS05170 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits PI93_RS05175 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) PI93_RS05180 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) PI93_RS05185 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) PI93_RS05190 ENOG4108ZT0 50S ribosomal protein l17 PI93_RS05200 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) PI93_RS05205 ENOG4105D52 delta-aminolevulinic acid dehydratase PI93_RS05210 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) PI93_RS05220 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) PI93_RS05225 ENOG4105CRE cytochrome C PI93_RS05230 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) PI93_RS05235 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) PI93_RS05240 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) PI93_RS05245 ENOG4105XQ6 frataxin-like protein PI93_RS05250 ENOG4108JQC penicillin-binding protein 1A PI93_RS05275 ENOG4105D49 3-dehydroquinate synthase PI93_RS05280 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein PI93_RS05290 ENOG4105EIF outer membrane protein W PI93_RS05295 ENOG4105EIF outer membrane protein W PI93_RS05315 ENOG4105DPW Major facilitator superfamily MFS_1 PI93_RS05320 ENOG4105E9Z Nad-dependent epimerase dehydratase PI93_RS05330 ENOG4107RGD Major Facilitator superfamily PI93_RS05335 ENOG4105CHR reductase PI93_RS05360 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) PI93_RS05370 ENOG4105DHJ ABC, transporter PI93_RS05375 ENOG4105CY3 ABC transporter, permease PI93_RS05380 ENOG4107PE3 Mammalian cell entry related domain protein PI93_RS05400 ENOG4105DA5 (ABC) transporter PI93_RS05405 ENOG4105E3A (ABC) transporter PI93_RS05425 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) PI93_RS05440 ENOG4105ECC imidazole-glycerol-phosphate dehydratase PI93_RS05445 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein PI93_RS05450 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) PI93_RS05455 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase PI93_RS05465 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase PI93_RS05480 ENOG4105K59 histidine triad (HIT) protein PI93_RS05485 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) PI93_RS05495 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) PI93_RS05500 ENOG4105C0H protease PI93_RS05505 ENOG4107QNR UPF0135 protein PI93_RS05515 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) PI93_RS05520 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) PI93_RS05525 ENOG4105EIX cytochrome c1 PI93_RS05530 ENOG4107MKT Stringent starvation protein a PI93_RS05535 ENOG4105KB2 stringent starvation protein b PI93_RS05575 ENOG4105GVR general secretion pathway protein D PI93_RS05670 ENOG4105DUM transcriptional regulator, lysR family PI93_RS05675 ENOG4105CSH Transporter PI93_RS05680 ENOG4105CH2 amidohydrolase PI93_RS05690 ENOG4106KNT transcriptional regulator PI93_RS05695 ENOG4105D2S major facilitator superfamily PI93_RS05710 ENOG4105C0A alcohol dehydrogenase PI93_RS05715 ENOG4105C26 Dehydrogenase PI93_RS05720 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family PI93_RS05725 ENOG4108RH0 Crea protein PI93_RS05745 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase PI93_RS05755 ENOG410802X bacteriophage n4 adsorption protein b PI93_RS05765 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate PI93_RS05775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein PI93_RS05780 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) PI93_RS05785 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) PI93_RS05805 ENOG4108VKG metal-dependent hydrolase PI93_RS05815 ENOG41079KZ Major Facilitator Superfamily PI93_RS05830 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) PI93_RS05840 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 PI93_RS05845 ENOG4107RN3 metallophosphoesterase PI93_RS05875 ENOG4108V3W Chemotaxis protein, CheW PI93_RS05880 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) PI93_RS05885 ENOG4105BZU Histidine kinase PI93_RS05890 ENOG4107SDU Methyl-accepting chemotaxis PI93_RS05910 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase PI93_RS05920 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) PI93_RS05925 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) PI93_RS05930 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) PI93_RS05945 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS05950 ENOG4105CUJ penicillin amidase PI93_RS05980 ENOG4105C3G gtp-binding protein PI93_RS05985 ENOG4105CGZ zinc metallopeptidase PI93_RS05990 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family PI93_RS05995 ENOG4105T95 Thiol disulfide interChange protein PI93_RS06005 ENOG4105HEI LysR family (Transcriptional regulator PI93_RS06030 ENOG4108ESX Receptor PI93_RS06035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) PI93_RS06045 ENOG4105DK0 Indole-3-glycerol phosphate synthase PI93_RS06050 ENOG4108I0Q anthranilate phosphoribosyltransferase PI93_RS06055 ENOG4105DDQ anthranilate synthase PI93_RS06060 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase PI93_RS06065 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PI93_RS06070 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) PI93_RS06075 ENOG4105XJC Two component transcriptional regulator (Winged helix family PI93_RS06080 ENOG4105DHQ Histidine kinase PI93_RS06090 ENOG4105CMI transporter PI93_RS06095 ENOG4105CJ1 ABC, transporter PI93_RS06100 ENOG4105D0S secretion protein (HlyD PI93_RS06105 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS06115 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) PI93_RS06120 ENOG4105DJV ribulose-phosphate 3-epimerase PI93_RS06125 ENOG4105NWN ApaG protein PI93_RS06130 ENOG4105CA3 membrane-bound lytic murein transglycosylase PI93_RS06140 ENOG4108ZJI phenylacetic acid degradation protein PI93_RS06145 ENOG4108UKI Enoyl-CoA hydratase PI93_RS06160 ENOG4105E39 Enoyl-CoA hydratase PI93_RS06165 ENOG4106PMH Extracellular solute-binding protein family 3 PI93_RS06200 ENOG4105CH2 amidohydrolase PI93_RS06205 ENOG4108J2R molybdopterin oxidoreductase PI93_RS06220 ENOG4108Z9W Outer membrane porin PI93_RS06235 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) PI93_RS06240 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) PI93_RS06245 ENOG4105CJN penicillin-binding protein PI93_RS06250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) PI93_RS06255 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) PI93_RS06265 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) PI93_RS06275 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) PI93_RS06280 ENOG4105DFU Cell wall formation (By similarity) PI93_RS06285 ENOG4105CPF Cell wall formation (By similarity) PI93_RS06290 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) PI93_RS06295 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) PI93_RS06300 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) PI93_RS06305 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) PI93_RS06315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving PI93_RS06320 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) PI93_RS06335 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) PI93_RS06360 ENOG4107QHF type ii secretion system protein e PI93_RS06365 ENOG4108JU6 CBS domain protein PI93_RS06375 ENOG4105EAH synthase PI93_RS06380 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) PI93_RS06385 ENOG4105K46 50S ribosomal protein l27 PI93_RS06390 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control PI93_RS06405 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) PI93_RS06410 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) PI93_RS06415 ENOG41076UM multiple antibiotic resistance (MarC)-related protein PI93_RS06420 ENOG4108UGV hypoxanthine phosphoribosyltransferase PI93_RS06425 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY PI93_RS06430 ENOG4105CRE cytochrome C PI93_RS06450 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) PI93_RS06460 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) PI93_RS06480 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) PI93_RS06485 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) PI93_RS06500 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase PI93_RS06505 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein PI93_RS06510 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) PI93_RS06515 ENOG4107ZT5 Thiol disulfide interchange protein PI93_RS06525 ENOG4105DFU Cell wall formation (By similarity) PI93_RS06530 ENOG4105IPS esterase PI93_RS06550 ENOG4105E2X shikimate dehydrogenase PI93_RS06555 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase PI93_RS06560 ENOG4105D64 Mechanosensitive ion channel PI93_RS06565 ENOG4107QUT magnesium and cobalt transport protein CorA PI93_RS06570 ENOG4105SKN orotidine 5''-phosphate decarboxylase PI93_RS06575 ENOG4105CEV competence damage-inducible protein PI93_RS06580 ENOG4108ZAI phosphatidylglycerophosphatase a PI93_RS06585 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) PI93_RS06590 ENOG4105C6K Malic enzyme PI93_RS06610 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) PI93_RS06620 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) PI93_RS06625 ENOG4105CV1 Transketolase (EC 2.2.1.1) PI93_RS06630 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase PI93_RS06640 ENOG41090R7 Ferric uptake PI93_RS06645 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) PI93_RS06650 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) PI93_RS06655 ENOG4105C8T Leucyl-tRNA synthetase PI93_RS06670 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) PI93_RS06680 ENOG4105E7U AraC family transcriptional regulator PI93_RS06695 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family PI93_RS06700 ENOG4108Z9W Outer membrane porin PI93_RS06705 ENOG4105DC1 bifunctional purine biosynthesis protein purh PI93_RS06710 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) PI93_RS06715 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) PI93_RS06720 ENOG4105D0A hydroxylase PI93_RS06725 ENOG4107RAQ aminopeptidase PI93_RS06730 ENOG4108S0S Nucleotidyl transferase PI93_RS06735 ENOG4105EHM Aminoglycoside phosphotransferase PI93_RS06745 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) PI93_RS06750 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) PI93_RS06765 ENOG4105VCQ rubredoxin PI93_RS06770 ENOG4108UYE Lactoylglutathione lyase PI93_RS06780 ENOG4105E9Q Acyl-transferase PI93_RS06785 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase PI93_RS06790 ENOG4105C38 Glycyl-tRNA synthetase beta subunit PI93_RS06795 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit PI93_RS06800 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) PI93_RS06805 ENOG4108JU5 Magnesium and cobalt efflux protein PI93_RS06810 ENOG4108NH8 Cation transport protein PI93_RS06820 ENOG4105C9A Phoh family PI93_RS06825 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) PI93_RS06830 ENOG4105DSE periplasmic solute binding protein PI93_RS06835 ENOG4105CC5 ABC transporter PI93_RS06840 ENOG4105DIK (ABC) transporter PI93_RS06845 ENOG4105CYN Serine protein kinase PI93_RS06850 ENOG4106AKX UPF0229 protein PI93_RS06855 ENOG4105ED1 spovr family PI93_RS06865 ENOG4105BZU Histidine kinase PI93_RS06870 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component PI93_RS06875 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system PI93_RS06880 ENOG4105E90 ABC transporter PI93_RS06885 ENOG4108IJ8 ABC transporter PI93_RS06890 ENOG4105CUY Mechanosensitive ion channel PI93_RS06905 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PI93_RS06920 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS06925 ENOG4108JCI Transcriptional regulator PI93_RS06930 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) PI93_RS06935 ENOG4105EXW epimerase dehydratase PI93_RS06965 ENOG4105F4G Membrane PI93_RS06970 ENOG41063Z6 transcriptional regulator, lysR family PI93_RS06975 ENOG4105EE5 Membrane protein terC PI93_RS07000 ENOG4105CSH Transporter PI93_RS07005 ENOG4105DHQ Histidine kinase PI93_RS07015 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) PI93_RS07020 ENOG4108004 Modulates RecA activity (By similarity) PI93_RS07030 ENOG4105CMV Succinyl-CoA synthetase subunit beta PI93_RS07035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha PI93_RS07040 ENOG4108ZCF integral membrane protein PI93_RS07045 ENOG4105KHS type IV fimbrial pilin protein PI93_RS07055 ENOG4105DWF phosphomethylpyrimidine kinase PI93_RS07060 ENOG4105VCQ rubredoxin PI93_RS07070 ENOG4108UJU UPF0301 protein PI93_RS07075 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) PI93_RS07080 ENOG4105CXT aspartate transcarbamylase PI93_RS07085 ENOG4105CD3 dihydroorotase PI93_RS07090 ENOG4108Z20 Acyl-transferase PI93_RS07095 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) PI93_RS07100 ENOG4105ESV Glycosyl transferase, family 4 PI93_RS07105 ENOG4105ESV Glycosyl transferase, family 4 PI93_RS07110 ENOG4107T8Q Glycosyl transferase (Group 1 PI93_RS07115 ENOG4108KMV Glycosyl transferase (Group 1 PI93_RS07120 ENOG4105CG5 Glycosyl transferase (Group 1 PI93_RS07135 ENOG4105D16 lipopolysaccharide heptosyltransferase i PI93_RS07145 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase PI93_RS07150 ENOG4105DFG type I secretion outer membrane protein PI93_RS07155 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) PI93_RS07160 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) PI93_RS07175 ENOG4105KRS Proteinase inhibitor PI93_RS07185 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) PI93_RS07195 ENOG4107YPT transcriptional regulator PI93_RS07225 ENOG4105F27 Major Facilitator PI93_RS07245 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) PI93_RS07260 ENOG4105VEQ Cold shock protein PI93_RS07265 ENOG4105F2Z 3-oxoadipate enol-lactonase PI93_RS07280 ENOG4105EVD ribosomal RNA large subunit methyltransferase N PI93_RS07300 ENOG4105MP9 class II Aldolase PI93_RS07305 ENOG4108JGH Tetr family transcriptional regulator PI93_RS07320 ENOG4105KPY Small multidrug resistance protein PI93_RS07325 ENOG4105CYM Glutathione S-transferase PI93_RS07340 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) PI93_RS07345 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF PI93_RS07370 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase PI93_RS07375 ENOG4105EQ0 Major Facilitator superfamily PI93_RS07380 ENOG4105JQN Transcriptional regulator PI93_RS07385 ENOG4105C5Q Transcriptional regulator PI93_RS07395 ENOG4105C26 Dehydrogenase PI93_RS07400 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS07405 ENOG4105FFC UPF0187 protein PI93_RS07430 ENOG4105CRW Short chain fatty acid transporter PI93_RS07445 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein PI93_RS07460 ENOG4105CUB amino acid PI93_RS07470 ENOG4105CJ3 phosphate transporter PI93_RS07475 ENOG4107QPD alcohol dehydrogenase PI93_RS07485 ENOG4105BZU Histidine kinase PI93_RS07490 ENOG4108WS1 PI93_RS07495 ENOG4105BZU Histidine kinase PI93_RS07500 ENOG41090EK ompa motb domain protein PI93_RS07515 ENOG4105HMI Membrane PI93_RS07545 ENOG4108M0I Transcriptional regulator PI93_RS07560 ENOG4105BZU Histidine kinase PI93_RS07565 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PI93_RS07570 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) PI93_RS07580 ENOG4106CAD Protein of unknown function (DUF3311) PI93_RS07585 ENOG4105E1V na solute symporter PI93_RS07595 ENOG4105DJ2 Major Facilitator Superfamily PI93_RS07605 ENOG4107QJQ Mate efflux family protein PI93_RS07615 ENOG4105E82 cytochrome subunit of dehydrogenase PI93_RS07620 ENOG4105DJ9 glucan biosynthesis protein PI93_RS07625 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) PI93_RS07630 ENOG4108K5P (LipO)protein PI93_RS07635 ENOG4105VEQ Cold shock protein PI93_RS07640 ENOG410829K Lysine exporter protein (Lyse ygga) PI93_RS07645 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) PI93_RS07655 ENOG4105C37 (CBS) domain PI93_RS07660 ENOG4105CC0 LysR family Transcriptional regulator PI93_RS07665 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b PI93_RS07675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) PI93_RS07680 ENOG4105EU8 FAD linked oxidase domain protein PI93_RS07685 ENOG4105CQB FAD linked oxidase domain protein PI93_RS07690 ENOG41073TP transcriptional regulator PI93_RS07695 ENOG4105FCD Major Facilitator PI93_RS07710 ENOG4108Z4U Ferredoxin PI93_RS07715 ENOG4107RH7 Nicotinate phosphoribosyltransferase PI93_RS07720 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) PI93_RS07750 ENOG4105CVM Molybdenum cofactor synthesis domain protein PI93_RS07755 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) PI93_RS07765 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PI93_RS07770 ENOG4105C03 ribonuclease PI93_RS07775 ENOG4105EI2 Pseudouridine synthase PI93_RS07780 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 PI93_RS07790 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) PI93_RS07795 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) PI93_RS07805 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein PI93_RS07810 ENOG4105VGS 50s ribosomal protein l32 PI93_RS07815 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) PI93_RS07820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) PI93_RS07825 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase PI93_RS07830 ENOG4105CHR reductase PI93_RS07835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) PI93_RS07840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) PI93_RS07845 ENOG4105EMN RNA polymerase sigma factor PI93_RS07860 ENOG4105C0H protease PI93_RS07875 ENOG4105C3F Signal peptidase i PI93_RS07880 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) PI93_RS07885 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) PI93_RS07895 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) PI93_RS07900 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) PI93_RS07905 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) PI93_RS07920 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) PI93_RS07925 ENOG4107SVH Potassium channel protein PI93_RS07930 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase PI93_RS07965 ENOG4105FDP GntR family transcriptional regulator PI93_RS07970 ENOG4108Z9W Outer membrane porin PI93_RS07975 ENOG4105EQX glucarate dehydratase PI93_RS07985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS07990 ENOG4105D56 permease protein PI93_RS08015 ENOG4105CWB LysR family transcriptional Regulator PI93_RS08020 ENOG4105CHJ isochorismatase hydrolase PI93_RS08065 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase PI93_RS08070 ENOG4105CTX dehydratase PI93_RS08080 ENOG4105CFC Transporter PI93_RS08105 ENOG41067HS methyltransferase PI93_RS08155 ENOG4107UWN reductase PI93_RS08175 ENOG4105E1V na solute symporter PI93_RS08180 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) PI93_RS08185 ENOG4105CH2 amidohydrolase PI93_RS08205 ENOG4105E5Q amino acid AbC transporter PI93_RS08210 ENOG4105DRP amino acid AbC transporter PI93_RS08215 ENOG4105EW9 transcriptional regulator AsnC family PI93_RS08225 ENOG4105WP5 PI93_RS08240 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) PI93_RS08245 ENOG4105II7 pyrroline-5-carboxylate reductase PI93_RS08250 ENOG4105DFA alanine racemase domain protein PI93_RS08265 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS08270 ENOG4105EU8 FAD linked oxidase domain protein PI93_RS08275 ENOG4105EYW Ion transport protein PI93_RS08280 ENOG4105CQB FAD linked oxidase domain protein PI93_RS08285 ENOG4105CQB FAD linked oxidase domain protein PI93_RS08290 ENOG4108WBT adenosyltransferase PI93_RS08295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) PI93_RS08300 ENOG4105D1U peptidase U62 modulator of DNA gyrase PI93_RS08315 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) PI93_RS08320 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) PI93_RS08340 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) PI93_RS08345 ENOG4105VEJ Heat shock protein PI93_RS08365 ENOG4105CFG Acts as a chaperone (By similarity) PI93_RS08410 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PI93_RS08420 ENOG4105ETX regulatoR PI93_RS08425 ENOG4105DHQ Histidine kinase PI93_RS08440 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase PI93_RS08445 ENOG4105DJ0 Poly(A) Polymerase PI93_RS08455 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) PI93_RS08460 ENOG4105CXB phosphoribosylaminoimidazole synthetase PI93_RS08470 ENOG4105CD3 dihydroorotase PI93_RS08480 ENOG4105F38 ABC transporter, permease PI93_RS08490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS08505 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) PI93_RS08510 ENOG4105DQR SNARE associated Golgi PI93_RS08515 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase PI93_RS08520 ENOG4105K8N protein family UPF0079, ATPase PI93_RS08525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) PI93_RS08530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) PI93_RS08535 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS08540 ENOG4108Z66 YbaK ebsC protein PI93_RS08545 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) PI93_RS08555 ENOG4105D4A Cell wall formation (By similarity) PI93_RS08565 ENOG4105NBK UPF0345 protein PI93_RS08570 ENOG4105DBV ornithine carbamoyltransferase PI93_RS08580 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) PI93_RS08585 ENOG4105CJR Integral membrane protein (MviN PI93_RS08590 ENOG41063JG Transcriptional regulator PI93_RS08605 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) PI93_RS08615 ENOG4105W49 UPF0434 protein PI93_RS08620 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) PI93_RS08630 ENOG4105E02 MotA TolQ exbB proton channel PI93_RS08635 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PI93_RS08640 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) PI93_RS08645 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase PI93_RS08665 ENOG4108R99 pseudouridine synthase PI93_RS08685 ENOG410642W LysR family Transcriptional regulator PI93_RS08690 ENOG4105F6U Short-chain dehydrogenase reductase Sdr PI93_RS08725 ENOG4105VEQ Cold shock protein PI93_RS08730 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) PI93_RS08735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PI93_RS08745 ENOG4105DEN Luciferase family PI93_RS08750 ENOG4105F9N Major Facilitator Superfamily PI93_RS08755 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase PI93_RS08760 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) PI93_RS08765 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) PI93_RS08770 ENOG4105DTN riboflavin biosynthesis protein ribF PI93_RS08775 ENOG4108V3E phosphoribosylglycinamide formyltransferase PI93_RS08785 ENOG4105EGS Mechanosensitive ion channel PI93_RS08795 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) PI93_RS08800 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase PI93_RS08805 ENOG4108IYU L-aspartate oxidase PI93_RS08810 ENOG4105W0E 50S ribosomal protein L33 PI93_RS08820 ENOG4105W5Q DNA repair protein (RadC PI93_RS08825 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase PI93_RS08830 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) PI93_RS08840 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS08845 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PI93_RS08850 ENOG4105C0Z ABC transporter PI93_RS08855 ENOG4108IV0 ABC, transporter PI93_RS08860 ENOG4108R6G acetyltransferase PI93_RS08870 ENOG4105C8Y Acetylornithine aminotransferase PI93_RS08875 ENOG4108EX3 reductase PI93_RS08885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS08895 ENOG4105DJY efflux transporter, rnd family, mfp subunit PI93_RS08910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PI93_RS08915 ENOG4105E0F Histidine kinase PI93_RS08920 ENOG4105CSR polyphosphate kinase 2 PI93_RS08930 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase PI93_RS08950 ENOG4105C6K Malic enzyme PI93_RS08955 ENOG4105DRP amino acid AbC transporter PI93_RS08960 ENOG4105EAD ABC transporter PI93_RS08965 ENOG4105EAB amino acid AbC transporter PI93_RS08980 ENOG4105DND Transcriptional regulator PI93_RS08990 ENOG41080HT Transcriptional regulator, arsr family PI93_RS09005 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS09010 ENOG4108YYQ gCN5-related N-acetyltransferase PI93_RS09015 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS PI93_RS09020 ENOG4105E0F Histidine kinase PI93_RS09025 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PI93_RS09035 ENOG4105BZS acriflavin resistance protein PI93_RS09040 ENOG4105BZS acriflavin resistance protein PI93_RS09045 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS09050 ENOG41068CG regulatoR PI93_RS09060 ENOG4105DSY exodeoxyribonuclease V, gamma PI93_RS09065 ENOG4107QKA exodeoxyribonuclease V beta PI93_RS09070 ENOG4107QYX exodeoxyribonuclease v alpha PI93_RS09075 ENOG4105C37 (CBS) domain PI93_RS09085 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) PI93_RS09095 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) PI93_RS09120 ENOG4108M0I Transcriptional regulator PI93_RS09125 ENOG4105DHU Bile acid PI93_RS09130 ENOG4105C1J atp-dependent rna helicase PI93_RS09135 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) PI93_RS09140 ENOG4105C72 UPF0176 protein PI93_RS09155 ENOG4106WTF Glycosyl transferase, family 2 PI93_RS09160 ENOG4105C9U ATP-dependent DNA helicase RecQ PI93_RS09180 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) PI93_RS09185 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase PI93_RS09195 ENOG4105C03 ribonuclease PI93_RS09200 ENOG4108Z03 MAF-like protein PI93_RS09205 ENOG4107T6V glycerophosphoryl diester phosphodiesterase PI93_RS09215 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component PI93_RS09220 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component PI93_RS09225 ENOG4105BZ7 extracellular solute-binding protein family 1 PI93_RS09235 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) PI93_RS09250 ENOG4105D64 Mechanosensitive ion channel PI93_RS09255 ENOG4105C12 Phosphoribosylglycinamide synthetase PI93_RS09260 ENOG4105CDY transcriptional regulatory protein PI93_RS09265 ENOG4105D7A ATP-binding protein PI93_RS09275 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) PI93_RS09280 ENOG4105CHR reductase PI93_RS09285 ENOG4108Z5K methylglyoxal synthase PI93_RS09290 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein PI93_RS09300 ENOG4108Z86 Glutamine amidotransferase PI93_RS09305 ENOG4108Z9W Outer membrane porin PI93_RS09310 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family PI93_RS09315 ENOG4107RSM transcriptional regulator PI93_RS09320 ENOG4107XBN GntR Family Transcriptional Regulator PI93_RS09330 ENOG4105C0A alcohol dehydrogenase PI93_RS09335 ENOG41079KZ Major Facilitator Superfamily PI93_RS09350 ENOG4105CG6 trap dicarboxylate transporter dctm subunit PI93_RS09355 ENOG4108ERU trap dicarboxylate transporter subunit DctP PI93_RS09360 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS09380 ENOG4105CHM Aminotransferase PI93_RS09390 ENOG4105C8Y Acetylornithine aminotransferase PI93_RS09415 ENOG4107SCK Monooxygenase PI93_RS09420 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PI93_RS09430 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS09460 ENOG4105C1P efflux transporter, rnd family, mfp subunit PI93_RS09465 ENOG4105BZS acriflavin resistance protein PI93_RS09470 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS09480 ENOG4105CC0 LysR family Transcriptional regulator PI93_RS09490 ENOG4105DUM transcriptional regulator, lysR family PI93_RS09495 ENOG4105VJY transcriptional regulator PI93_RS09510 ENOG4105Y49 secretion protein, HlyD family PI93_RS09530 ENOG4108SY4 MarR family Transcriptional regulator PI93_RS09535 ENOG4105CHR reductase PI93_RS09540 ENOG4108IPT Naphthoate synthase PI93_RS09550 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS09555 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS09560 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS09565 ENOG4108IFG nitrite reductase, (NAD(P)H) PI93_RS09580 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PI93_RS09600 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA PI93_RS09635 ENOG4108W9H Tetr family transcriptional regulator PI93_RS09640 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS09645 ENOG4107Z6I Thiamine biosynthesis protein PI93_RS09680 ENOG4107K5X Membrane-bound metal-dependent hydrolase PI93_RS09685 ENOG4105E27 serine threonine protein kinase PI93_RS09735 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS09745 ENOG4105C3U ABC transporter PI93_RS09750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS09755 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PI93_RS09760 ENOG4105E1J oxidoreductase PI93_RS09770 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) PI93_RS09785 ENOG4105BZU Histidine kinase PI93_RS09795 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS09810 ENOG4105CPT Alpha beta hydrolase PI93_RS09825 ENOG4108Z7F N-acetyltransferase PI93_RS09840 ENOG4107TJ9 Cytochrome PI93_RS09855 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) PI93_RS09865 ENOG4105E0X reductase PI93_RS09870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PI93_RS09895 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) PI93_RS09900 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) PI93_RS09905 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS09915 ENOG4108ZT1 Transcriptional regulator PI93_RS09925 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) PI93_RS09930 ENOG4105ERG peptidase m48, ste24p PI93_RS09945 ENOG4105DNZ Alpha Beta Hydrolase PI93_RS09955 ENOG4105XA0 heptosyltransferase ii PI93_RS09975 ENOG4105BZA Phosphoglycerate kinase PI93_RS09980 ENOG4105CA9 Pyruvate kinase PI93_RS10000 ENOG4105C8V SAICAR synthetase PI93_RS10005 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) PI93_RS10010 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit PI93_RS10015 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) PI93_RS10025 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase PI93_RS10030 ENOG4105XJC Two component transcriptional regulator (Winged helix family PI93_RS10035 ENOG4105DHQ Histidine kinase PI93_RS10045 ENOG4105C0H protease PI93_RS10055 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family PI93_RS10065 ENOG4105F4R Transcriptional regulator mode PI93_RS10070 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) PI93_RS10075 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) PI93_RS10085 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) PI93_RS10090 ENOG4105E0C molybdate abc transporter PI93_RS10095 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein PI93_RS10100 ENOG4108IG5 Transcriptional regulator PI93_RS10105 ENOG4105C1P efflux transporter, rnd family, mfp subunit PI93_RS10110 ENOG4105BZS acriflavin resistance protein PI93_RS10115 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS10155 ENOG4105TNS Conserved Protein PI93_RS10160 ENOG4105D3R alkyl hydroperoxide reductase PI93_RS10165 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS10175 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) PI93_RS10185 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) PI93_RS10225 ENOG4105EAB amino acid AbC transporter PI93_RS10230 ENOG4105E5Q amino acid AbC transporter PI93_RS10235 ENOG4105CDA abc transporter atp-binding protein PI93_RS10240 ENOG41088SP formiminoglutamate hydrolase PI93_RS10245 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) PI93_RS10260 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS10265 ENOG4105RKW reductase (By PI93_RS10275 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase PI93_RS10280 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) PI93_RS10285 ENOG41066T0 asmA family PI93_RS10290 ENOG4105CUZ uba thif-type nad fad binding protein PI93_RS10295 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS10325 ENOG4108X07 Tetr family transcriptional regulator PI93_RS10330 ENOG4105C85 amino acid PI93_RS10335 ENOG4108Z9W Outer membrane porin PI93_RS10340 ENOG4105F7P transcriptional regulator AsnC family PI93_RS10345 ENOG4105DMF Dehydrogenase PI93_RS10355 ENOG4105F04 LysR family Transcriptional regulator PI93_RS10360 ENOG4105CSH Transporter PI93_RS10370 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) PI93_RS10395 ENOG4105E2Y ABC, transporter PI93_RS10405 ENOG4107Z6I Thiamine biosynthesis protein PI93_RS10415 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) PI93_RS10420 ENOG4105FDT acyl-CoA dehydrogenase PI93_RS10425 ENOG4108T2C cysteine dioxygenase type I PI93_RS10445 ENOG4105C0A alcohol dehydrogenase PI93_RS10450 ENOG4108IV0 ABC, transporter PI93_RS10465 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS10475 ENOG4105C26 Dehydrogenase PI93_RS10480 ENOG4107258 Transcriptional regulator PI93_RS10490 ENOG4107XBN GntR Family Transcriptional Regulator PI93_RS10495 ENOG4105C5R Aminotransferase PI93_RS10500 ENOG4105DJB Major Facilitator Superfamily PI93_RS10505 ENOG4105CQB FAD linked oxidase domain protein PI93_RS10550 ENOG4105CHR reductase PI93_RS10590 ENOG4105E3A (ABC) transporter PI93_RS10595 ENOG4105DA5 (ABC) transporter PI93_RS10600 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase PI93_RS10615 ENOG4105CBN LysR family transcriptional regulator PI93_RS10630 ENOG4108YXU transcriptional regulator AsnC family PI93_RS10645 ENOG4108ZHJ Organic hydroperoxide resistance protein PI93_RS10655 ENOG41069P5 Protein slyX homolog PI93_RS10660 ENOG4105KK4 UPF0060 membrane protein PI93_RS10675 ENOG4105CBN LysR family transcriptional regulator PI93_RS10685 ENOG4105EW9 transcriptional regulator AsnC family PI93_RS10690 ENOG4108NIW Leucine export protein LeuE PI93_RS10695 ENOG4105E2S oxidase) subunit II PI93_RS10700 ENOG4105BZ9 Cytochrome C oxidase, subunit I PI93_RS10705 ENOG4105CCU oxidase (Subunit III) PI93_RS10710 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) PI93_RS10725 ENOG4108NIW Leucine export protein LeuE PI93_RS10745 ENOG4106NZI LysR family Transcriptional regulator PI93_RS10750 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PI93_RS10755 ENOG4108KS2 transglutaminase domain protein PI93_RS10785 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) PI93_RS10805 ENOG4107R7Y intracellular protease Pfpi family PI93_RS10810 ENOG4105EWC Purine nucleoside phosphorylase PI93_RS10820 ENOG4105CC0 LysR family Transcriptional regulator PI93_RS10825 ENOG4105CPQ Dehydrogenase PI93_RS10835 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) PI93_RS10850 ENOG4108Z9W Outer membrane porin PI93_RS10870 ENOG4105C26 Dehydrogenase PI93_RS10900 ENOG410811B TRANSCRIPTIONal PI93_RS10910 ENOG4108IV0 ABC, transporter PI93_RS10915 ENOG4105C0Z ABC transporter PI93_RS10925 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS10975 ENOG4105ECW sulfate abc transporter PI93_RS10980 ENOG4105E0C molybdate abc transporter PI93_RS10985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS10990 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) PI93_RS10995 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) PI93_RS11020 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 PI93_RS11025 ENOG4105CXT aspartate transcarbamylase PI93_RS11045 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS11050 ENOG4105C54 Major Facilitator superfamily PI93_RS11055 ENOG41088CC tellurite resistance protein tehB PI93_RS11060 ENOG4105CD8 aminopeptidase N PI93_RS11085 ENOG4107QUY Guanine deaminase PI93_RS11090 ENOG4105C7N Xanthine uracil vitamin C permease PI93_RS11095 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) PI93_RS11105 ENOG4105C7W Xanthine dehydrogenase PI93_RS11120 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) PI93_RS11145 ENOG4105CKD glutathione-regulated potassium-efflux system protein PI93_RS11155 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) PI93_RS11160 ENOG410681U heavy metal transport detoxification protein PI93_RS11165 ENOG4105C59 p-type ATPase PI93_RS11170 ENOG4105X23 Endonuclease Exonuclease phosphatase PI93_RS11195 ENOG4107Y60 (LipO)protein PI93_RS11205 ENOG4106B0W Curli production assembly transport component CsgG PI93_RS11230 ENOG4105C0B DNA polymerase III (alpha subunit) PI93_RS11235 ENOG41080ET plasmid maintenance system killer protein PI93_RS11245 ENOG4105C2W permease PI93_RS11255 ENOG4105BZU Histidine kinase PI93_RS11265 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS11270 ENOG4105MWK D-amino acid dehydrogenase, small subunit PI93_RS11285 ENOG4105C1J atp-dependent rna helicase PI93_RS11290 ENOG4105C7I Dehydrogenase PI93_RS11295 ENOG4105GVF (ABC) transporter PI93_RS11325 ENOG4105C7N Xanthine uracil vitamin C permease PI93_RS11330 ENOG4108Z9W Outer membrane porin PI93_RS11345 ENOG4105EAM Na Pi-cotransporter PI93_RS11350 ENOG4105F9N Major Facilitator Superfamily PI93_RS11355 ENOG4105JAB phenazine biosynthesis protein, phzf family PI93_RS11360 ENOG4105CSP Major Facilitator Superfamily PI93_RS11365 ENOG4105E9K Isocitrate dehydrogenase PI93_RS11375 ENOG4107RZZ dna polymerase iii epsilon subunit PI93_RS11380 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) PI93_RS11390 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PI93_RS11395 ENOG4105E9H Lytic Murein transglycosylase PI93_RS11400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) PI93_RS11405 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS11410 ENOG4107RSM transcriptional regulator PI93_RS11420 ENOG4105CSH Transporter PI93_RS11435 ENOG4105CKT filamentous hemagglutinin PI93_RS11450 ENOG4105DTD Dehydrogenase PI93_RS11455 ENOG4108UKI Enoyl-CoA hydratase PI93_RS11460 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS11485 ENOG4105DHG Allantoate amidinohydrolase PI93_RS11490 ENOG4105CK2 sodium dicarboxylate symporter PI93_RS11495 ENOG4107EXU Short-chain dehydrogenase reductase Sdr PI93_RS11510 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain PI93_RS11515 ENOG4108NIW Leucine export protein LeuE PI93_RS11520 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain PI93_RS11525 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) PI93_RS11535 ENOG4105HBR Rna-binding protein PI93_RS11545 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) PI93_RS11550 ENOG4105EEI dihydropteroate synthase PI93_RS11560 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) PI93_RS11565 ENOG4105C8U phosphate abc transporter PI93_RS11570 ENOG4105E2Z phosphate ABC transporter (Permease PI93_RS11575 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) PI93_RS11585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family PI93_RS11590 ENOG4105BZU Histidine kinase PI93_RS11595 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) PI93_RS11600 ENOG4105C9X ppx gppa phosphatase PI93_RS11630 ENOG4108Z9W Outer membrane porin PI93_RS11640 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS11645 ENOG4107XCH Cyclase family PI93_RS11650 ENOG4108PVQ transcriptional regulator PI93_RS11660 ENOG41080V3 Major Facilitator superfamily PI93_RS11665 ENOG4105D3W isochorismatase PI93_RS11675 ENOG4108PVQ transcriptional regulator PI93_RS11680 ENOG4108Z9W Outer membrane porin PI93_RS11705 ENOG4105CHR reductase PI93_RS11710 ENOG4108Z9W Outer membrane porin PI93_RS11720 ENOG4105IKQ hydratase PI93_RS11725 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 PI93_RS11730 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS11735 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS11755 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase PI93_RS11760 ENOG4105VQD rieske 2fe-2S domain-containing protein PI93_RS11770 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS11780 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) PI93_RS11810 ENOG4108Z9W Outer membrane porin PI93_RS11855 ENOG4106PA8 Plays an important role in the de novo pathway of purine nucleotide biosynthesis PI93_RS11865 ENOG41079KZ Major Facilitator Superfamily PI93_RS11870 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PI93_RS11880 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS11885 ENOG4108Z9W Outer membrane porin PI93_RS11890 ENOG4105FDP GntR family transcriptional regulator PI93_RS11900 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS11905 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PI93_RS11910 ENOG4105C0Z ABC transporter PI93_RS11915 ENOG4108IV0 ABC, transporter PI93_RS11920 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS11925 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS11940 ENOG4105D3W isochorismatase PI93_RS11955 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS11960 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) PI93_RS11965 ENOG4105CBP Major Facilitator PI93_RS11970 ENOG4105MP9 class II Aldolase PI93_RS11975 ENOG41084KP 4-oxalocrotonate tautomerase PI93_RS11980 ENOG4105C5W Aldolase PI93_RS11995 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) PI93_RS12000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase PI93_RS12005 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) PI93_RS12010 ENOG4105C4R Atp-dependent dna helicase PI93_RS12020 ENOG4105CUV Homoserine Kinase PI93_RS12030 ENOG41066VF YeeE YedE family protein PI93_RS12040 ENOG4105C2M dna polymerase I PI93_RS12045 ENOG4105CEP NADH dehydrogenase PI93_RS12050 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) PI93_RS12060 ENOG4105KHC sulfurtransferase PI93_RS12075 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) PI93_RS12085 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) PI93_RS12095 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) PI93_RS12100 ENOG4105CBX hi0933 family PI93_RS12105 ENOG4105KTH gatB Yqey PI93_RS12125 ENOG4105DWY Agmatine deiminase PI93_RS12130 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS12140 ENOG4107RB3 L-asparaginase PI93_RS12150 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS12160 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS12165 ENOG4105CYC Transferase PI93_RS12170 ENOG4106NZI LysR family Transcriptional regulator PI93_RS12180 ENOG41066DG (EAL) domain protein PI93_RS12195 ENOG4105D2S major facilitator superfamily PI93_RS12200 ENOG4105C2C drug resistance transporter, Bcr CflA PI93_RS12220 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS12225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS12230 ENOG4105C01 Dihydroxy-acid dehydratase PI93_RS12240 ENOG4105CSP Major Facilitator Superfamily PI93_RS12245 ENOG4105DDW LysR family Transcriptional regulator PI93_RS12255 ENOG4105D01 (LipO)protein PI93_RS12265 ENOG4108JU7 Transcriptional regulator PI93_RS12270 ENOG4105CR4 methylisocitrate lyase PI93_RS12275 ENOG4105BZN citrate synthase PI93_RS12280 ENOG4108I0Z Aconitate hydratase PI93_RS12285 ENOG4105C7F AcnD-accessory protein PrpF PI93_RS12290 ENOG4105DXD 2-methylcitrate dehydratase PI93_RS12300 ENOG4105BZW Glycerate kinase PI93_RS12310 ENOG4105E98 transcriptional regulator DeoR family PI93_RS12315 ENOG4105C6V Glycerol-3-phosphate dehydrogenase PI93_RS12320 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) PI93_RS12335 ENOG4108M0I Transcriptional regulator PI93_RS12345 ENOG4107QWP ABC-2 type transporter PI93_RS12350 ENOG4105CJ1 ABC, transporter PI93_RS12355 ENOG4105CW7 secretion protein, HlyD family PI93_RS12360 ENOG4105EUJ GTP cyclohydrolase i PI93_RS12375 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii PI93_RS12380 ENOG4105C4M (Ubiquinol oxidase) subunit I PI93_RS12405 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PI93_RS12415 ENOG4105CSP Major Facilitator Superfamily PI93_RS12440 ENOG4105DS1 cytochrome b561 PI93_RS12455 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) PI93_RS12480 ENOG4107SCA Formamidase (EC 3.5.1.49) PI93_RS12485 ENOG4105CSH Transporter PI93_RS12495 ENOG4108Z9W Outer membrane porin PI93_RS12500 ENOG4105CGP Urocanate hydratase PI93_RS12515 ENOG4105CD3 dihydroorotase PI93_RS12530 ENOG4105RQF LysR family Transcriptional regulator PI93_RS12540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS12545 ENOG4105F38 ABC transporter, permease PI93_RS12550 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component PI93_RS12575 ENOG4105BZU Histidine kinase PI93_RS12590 ENOG4108IQE Amp-dependent synthetase and ligase PI93_RS12595 ENOG4105C0Z ABC transporter PI93_RS12600 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS12615 ENOG4108IV0 ABC, transporter PI93_RS12625 ENOG4105D2S major facilitator superfamily PI93_RS12645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase PI93_RS12660 ENOG4108IG5 Transcriptional regulator PI93_RS12670 ENOG4107QIJ Aconitate hydratase 2 PI93_RS12720 ENOG4106YJS accessory processing protein PI93_RS12735 ENOG4105XJC Two component transcriptional regulator (Winged helix family PI93_RS12740 ENOG4105BZU Histidine kinase PI93_RS12745 ENOG41068CG regulatoR PI93_RS12765 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PI93_RS12810 ENOG4108JJA ABC, transporter PI93_RS12825 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS12835 ENOG4105C0Z ABC transporter PI93_RS12840 ENOG4108IV0 ABC, transporter PI93_RS12870 ENOG4105CSA Coproporphyrinogen iii oxidase PI93_RS12875 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) PI93_RS12885 ENOG4105DSJ YicC domain protein PI93_RS12900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) PI93_RS12910 ENOG4105EUB pirin domain protein PI93_RS12920 ENOG4107QR8 Thioredoxin PI93_RS12935 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS12940 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS12950 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) PI93_RS12955 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) PI93_RS12960 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) PI93_RS12965 ENOG4105C08 Histidine kinase PI93_RS12970 ENOG4105EEX Two component transcriptional regulator (Winged helix family PI93_RS12975 ENOG4105KPY Small multidrug resistance protein PI93_RS12985 ENOG4105CV6 ABC transporter, permease PI93_RS12990 ENOG4108Z18 K06886 hemoglobin PI93_RS13005 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) PI93_RS13020 ENOG4108URH decarboxylase PI93_RS13025 ENOG4107Z3H Transcriptional regulator, TetR family PI93_RS13030 ENOG41080IJ Diacylglycerol kinase PI93_RS13035 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) PI93_RS13065 ENOG4108SF5 RNA Polymerase PI93_RS13070 ENOG4105C7K acetolactate synthase PI93_RS13075 ENOG4108ZP8 Acetolactate synthase small subunit PI93_RS13080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase PI93_RS13085 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme PI93_RS13090 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase PI93_RS13095 ENOG4109066 lysm domain bon superfamily protein PI93_RS13110 ENOG4105CP9 extracellular ligand-binding receptor PI93_RS13115 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) PI93_RS13150 ENOG4107QI1 Mate efflux family protein PI93_RS13160 ENOG4105NRA 50s ribosomal protein l31 type b PI93_RS13185 ENOG4105CQB FAD linked oxidase domain protein PI93_RS13195 ENOG4105CS1 NAD(P)H quinone oxidoreductase PI93_RS13210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) PI93_RS13225 ENOG4107S74 Lysophospholipid transporter LplT PI93_RS13240 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase PI93_RS13245 ENOG4108R85 Short chain dehydrogenase PI93_RS13250 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit PI93_RS13260 ENOG4108KX4 response regulator PI93_RS13275 ENOG4105DTD Dehydrogenase PI93_RS13285 ENOG4105M4H endoribonuclease L-psp PI93_RS13290 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) PI93_RS13300 ENOG4105C22 threonyL-tRNA synthetase PI93_RS13305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) PI93_RS13315 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) PI93_RS13330 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) PI93_RS13340 ENOG4105BZU Histidine kinase PI93_RS13345 ENOG4105BZU Histidine kinase PI93_RS13355 ENOG4105VCQ rubredoxin PI93_RS13380 ENOG4105BZU Histidine kinase PI93_RS13385 ENOG4105WQ3 Rna-binding protein PI93_RS13395 ENOG4105BZU Histidine kinase PI93_RS13400 ENOG4108MEJ flavin reductase domain protein PI93_RS13420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS13425 ENOG4105F38 ABC transporter, permease PI93_RS13430 ENOG4105D38 putrescine abc transporter PI93_RS13485 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) PI93_RS13530 ENOG4106P2F Pfam:Pili_assembly_C PI93_RS13535 ENOG4105CW0 outer membrane usher protein PI93_RS13575 ENOG4108JQC penicillin-binding protein 1A PI93_RS13585 ENOG4105WAP TPR repeat-containing protein PI93_RS13590 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS13600 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) PI93_RS13605 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) PI93_RS13610 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 PI93_RS13615 ENOG4105C7S Dehydrogenase PI93_RS13620 ENOG4107QN2 dihydrolipoyl dehydrogenase PI93_RS13625 ENOG4105D6Z AFG1 family ATPase PI93_RS13740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PI93_RS13750 ENOG4105DFH Transport of potassium into the cell (By similarity) PI93_RS13755 ENOG4105BZM domain protein PI93_RS13770 ENOG4105DVT helicase PI93_RS13775 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain PI93_RS13790 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase PI93_RS13800 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class PI93_RS13805 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS13810 ENOG4105CHR reductase PI93_RS13820 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) PI93_RS13825 ENOG4107UEK pfkb domain protein PI93_RS13830 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS13835 ENOG4105C28 cystathionine PI93_RS13840 ENOG4105EAC phosphoserine phosphatase PI93_RS13855 ENOG4105CIF Ornithine Cyclodeaminase PI93_RS13865 ENOG4105CSH Transporter PI93_RS13870 ENOG4105CWC Acetylornithine deacetylase PI93_RS13875 ENOG4108JA2 transcriptioN-repair coupling factor PI93_RS13880 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) PI93_RS13890 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) PI93_RS13895 ENOG4105D3R alkyl hydroperoxide reductase PI93_RS13900 ENOG4105E0F Histidine kinase PI93_RS13905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PI93_RS13995 ENOG4105VEQ Cold shock protein PI93_RS14020 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) PI93_RS14040 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS14060 ENOG4105CBN LysR family transcriptional regulator PI93_RS14065 ENOG4105XYF acetyltransferase PI93_RS14075 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS14090 ENOG4108DIG cyanophycin synthetase PI93_RS14095 ENOG4105BZ1 (ABC) transporter PI93_RS14105 ENOG4105DH7 May be involved in recombination (By similarity) PI93_RS14120 ENOG4105HEI LysR family (Transcriptional regulator PI93_RS14125 ENOG4105CAN Short-chain dehydrogenase reductase Sdr PI93_RS14130 ENOG4105EWI Short-chain dehydrogenase reductase Sdr PI93_RS14145 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) PI93_RS14150 ENOG4107QMS site-determining protein PI93_RS14155 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) PI93_RS14165 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS14170 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS14180 ENOG4105CHR reductase PI93_RS14185 ENOG4107QPN acyl-Coa dehydrogenase PI93_RS14195 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation PI93_RS14200 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) PI93_RS14210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) PI93_RS14215 ENOG4105K70 DNA-binding protein PI93_RS14230 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) PI93_RS14235 ENOG4108UJV acyl-CoA thioesterase i PI93_RS14240 ENOG4108I0Y (ABC) transporter PI93_RS14245 ENOG4107QP8 phosphohexose isomerase PI93_RS14250 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) PI93_RS14255 ENOG4105MWK D-amino acid dehydrogenase, small subunit PI93_RS14260 ENOG4108ETH Formylglycinamide ribotide synthetase PI93_RS14265 ENOG4107TF3 peptidylprolyl cis-trans isomerase PI93_RS14275 ENOG4107835 probably involved in intracellular septation (By similarity) PI93_RS14285 ENOG4105E0X reductase PI93_RS14290 ENOG4105CNG UPF0061 protein PI93_RS14295 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS14300 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS14310 ENOG4105C0Z ABC transporter PI93_RS14315 ENOG4108IV0 ABC, transporter PI93_RS14325 ENOG4108RWI nicotinamidase PI93_RS14335 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein PI93_RS14350 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) PI93_RS14355 ENOG4105HHA aminodeoxychorismate lyase PI93_RS14360 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) PI93_RS14365 ENOG4107QRG dna polymerase iii PI93_RS14370 ENOG4105F8V Hydrolase, tatD family PI93_RS14385 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase PI93_RS14390 ENOG4108K4C ec 3.1.3.12 PI93_RS14395 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) PI93_RS14400 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 PI93_RS14405 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS14410 ENOG4105BZU Histidine kinase PI93_RS14415 ENOG4108UT2 hemolysin iii PI93_RS14425 ENOG4108XM1 transcriptional regulator AsnC family PI93_RS14430 ENOG4105C7K acetolactate synthase PI93_RS14435 ENOG4106PMH Extracellular solute-binding protein family 3 PI93_RS14440 ENOG4105E5Q amino acid AbC transporter PI93_RS14455 ENOG4105F4X arginine PI93_RS14490 ENOG4105CD5 CoA-binding domain protein PI93_RS14495 ENOG4105D7N magnesium and cobalt transport protein CorA PI93_RS14520 ENOG4105BZU Histidine kinase PI93_RS14530 ENOG4105F1J Homogentisate 1,2-dioxygenase PI93_RS14550 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) PI93_RS14555 ENOG4105C26 Dehydrogenase PI93_RS14565 ENOG4108YYH Nadph-dependent fmn reductase PI93_RS14585 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) PI93_RS14615 ENOG4107EEX Cellulose synthase regulator protein PI93_RS14620 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) PI93_RS14625 ENOG4105EJG cellulose synthase PI93_RS14630 ENOG4105EJG cellulose synthase PI93_RS14640 ENOG4107QZ7 Cellulose synthase catalytic subunit PI93_RS14645 ENOG4105D1V cellulose synthase operon protein YhjU PI93_RS14650 ENOG4105CPC Aldo Keto reductase PI93_RS14660 ENOG4105PGM cation diffusion facilitator family transporter PI93_RS14685 ENOG4105BZS acriflavin resistance protein PI93_RS14690 ENOG4105ENT Efflux transporter rnd family, mfp subunit PI93_RS14695 ENOG4105CHR reductase PI93_RS14705 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class PI93_RS14710 ENOG4105MH5 phosphoesterase PA-phosphatase related protein PI93_RS14715 ENOG4105EXC Acyl-transferase PI93_RS14720 ENOG4105DR5 peptidase PI93_RS14725 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) PI93_RS14735 ENOG4105EMN RNA polymerase sigma factor PI93_RS14745 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) PI93_RS14790 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS14795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS14815 ENOG4105BZU Histidine kinase PI93_RS14845 ENOG4108S3W Anti-feci sigma factor, fecr PI93_RS14850 ENOG4108SF5 RNA Polymerase PI93_RS14855 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) PI93_RS14860 ENOG4105E9F Enoyl-CoA hydratase PI93_RS14865 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) PI93_RS14870 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme PI93_RS14880 ENOG4108IQE Amp-dependent synthetase and ligase PI93_RS14885 ENOG4107RGD Major Facilitator superfamily PI93_RS14905 ENOG4106KR7 LysR family Transcriptional regulator PI93_RS14930 ENOG4105WH1 Two component transcriptional regulator luxr family PI93_RS14935 ENOG4105DZC cytosine deaminase PI93_RS14945 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) PI93_RS14950 ENOG4105SKE transcriptional Regulator LysR family PI93_RS14955 ENOG4105S0E allantoin catabolism protein PI93_RS14975 ENOG41073TP transcriptional regulator PI93_RS14995 ENOG4105C5I Dehydrogenase PI93_RS15000 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS15005 ENOG4107XKF NMT1 THI5 Like Domain Protein PI93_RS15010 ENOG4108UYE Lactoylglutathione lyase PI93_RS15015 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component PI93_RS15030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS15040 ENOG4105C85 amino acid PI93_RS15065 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa PI93_RS15075 ENOG4105DPZ Two component transcriptional regulator (Winged helix family PI93_RS15080 ENOG4105E0F Histidine kinase PI93_RS15085 ENOG4108ZHJ Organic hydroperoxide resistance protein PI93_RS15100 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS15115 ENOG41088SP formiminoglutamate hydrolase PI93_RS15125 ENOG4105C85 amino acid PI93_RS15130 ENOG4105C84 Histidine ammonia-lyase PI93_RS15140 ENOG4105CZE histidine utilization repressor PI93_RS15145 ENOG4105GVF (ABC) transporter PI93_RS15150 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) PI93_RS15165 ENOG4105EJC lysr family transcriptional regulator PI93_RS15190 ENOG4107UWA esterase PI93_RS15210 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS15230 ENOG4105CI0 Citrate lyase PI93_RS15240 ENOG4105D2K citrate carrier protein PI93_RS15245 ENOG4106P55 Transcriptional regulator PI93_RS15250 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) PI93_RS15260 ENOG4105D7W serine acetyltransferase PI93_RS15295 ENOG4105CR8 Transcriptional regulator PI93_RS15300 ENOG4105C2I pirin domain protein PI93_RS15320 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS15335 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase PI93_RS15345 ENOG4105E39 Enoyl-CoA hydratase PI93_RS15350 ENOG4107QX3 carboxylase PI93_RS15355 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS15360 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit PI93_RS15365 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein PI93_RS15370 ENOG4105CHR reductase PI93_RS15375 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS15380 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS15390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS15395 ENOG4105C3U ABC transporter PI93_RS15400 ENOG4108JQ7 (ABC) transporter PI93_RS15410 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS15415 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS15440 ENOG4108J5G 6-phosphogluconate dehydrogenase PI93_RS15445 ENOG4105DHQ Histidine kinase PI93_RS15450 ENOG4105XJC Two component transcriptional regulator (Winged helix family PI93_RS15480 ENOG4108SF5 RNA Polymerase PI93_RS15490 ENOG4108Z9W Outer membrane porin PI93_RS15500 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS15520 ENOG4105DWT malate dehydrogenase (quinone) PI93_RS15525 ENOG4105D1S lipid A biosynthesis PI93_RS15540 ENOG4108I5G Major Facilitator superfamily PI93_RS15545 ENOG4105CXK mandelate racemase muconate lactonizing PI93_RS15555 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein PI93_RS15580 ENOG4105JSC dimethylmenaquinone methyltransferase PI93_RS15590 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) PI93_RS15595 ENOG4107RDJ Sulfotransferase PI93_RS15610 ENOG4105DG4 malate L-lactate dehydrogenase PI93_RS15620 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS15625 ENOG4108RXX maleylacetoacetate isomerase PI93_RS15630 ENOG4105K6V RNA polymerase PI93_RS15645 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase PI93_RS15660 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase PI93_RS15670 ENOG41085FC arsR family transcriptional regulator PI93_RS15680 ENOG4105D6J arsenicaL-resistance protein PI93_RS15710 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) PI93_RS15745 ENOG4105BZN citrate synthase PI93_RS15750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS15755 ENOG4105BZU Histidine kinase PI93_RS15760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase PI93_RS15795 ENOG4105C1J atp-dependent rna helicase PI93_RS15810 ENOG4105DHQ Histidine kinase PI93_RS15815 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) PI93_RS15840 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS15850 ENOG4105GR3 Histidine kinase PI93_RS15875 ENOG4108YZN class I peptide chain release factor PI93_RS15895 ENOG4107QJQ Mate efflux family protein PI93_RS15900 ENOG4105F27 Major Facilitator PI93_RS15905 ENOG4105WS7 Cation transport regulator PI93_RS15920 ENOG4105K3G Periplasmic Protein PI93_RS15940 ENOG4105EGS Mechanosensitive ion channel PI93_RS15945 ENOG4105BZU Histidine kinase PI93_RS15980 ENOG4105EA8 2-Nitropropane dioxygenase PI93_RS15985 ENOG4105EA8 2-Nitropropane dioxygenase PI93_RS15990 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family PI93_RS15995 ENOG4108IV0 ABC, transporter PI93_RS16000 ENOG4105C0Z ABC transporter PI93_RS16025 ENOG4105BZU Histidine kinase PI93_RS16040 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS16055 ENOG4105BZU Histidine kinase PI93_RS16070 ENOG4105F38 ABC transporter, permease PI93_RS16075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS16085 ENOG4105E39 Enoyl-CoA hydratase PI93_RS16090 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) PI93_RS16095 ENOG4105DG4 malate L-lactate dehydrogenase PI93_RS16100 ENOG4107QPK )-transporter PI93_RS16115 ENOG4105C8J )-transporter PI93_RS16140 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) PI93_RS16145 ENOG4108IEG Formate dehydrogenase Alpha subunit PI93_RS16155 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit PI93_RS16165 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit PI93_RS16200 ENOG4105DP0 ferredoxin-NADP reductase PI93_RS16205 ENOG4105CMR udp-glucose 4-epimerase PI93_RS16230 ENOG4108X4D Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) PI93_RS16255 ENOG4107S7U Sulfide dehydrogenase PI93_RS16260 ENOG4105BZU Histidine kinase PI93_RS16265 ENOG4105BZU Histidine kinase PI93_RS16290 ENOG4105C5H ABC transporter PI93_RS16310 ENOG4105UIB (ABC) transporter PI93_RS16315 ENOG4105C2J ABC transporter PI93_RS16325 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) PI93_RS16330 ENOG4105C2W permease PI93_RS16335 ENOG4105VT2 5-hydroxyisourate hydrolase PI93_RS16375 ENOG4105DHG Allantoate amidinohydrolase PI93_RS16390 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A PI93_RS16395 ENOG4108Z6B deaminase PI93_RS16405 ENOG4105CV8 reductase PI93_RS16420 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS16430 ENOG4105C0Z ABC transporter PI93_RS16435 ENOG4108IV0 ABC, transporter PI93_RS16450 ENOG4105EJC lysr family transcriptional regulator PI93_RS16460 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS16465 ENOG4105CHR reductase PI93_RS16480 ENOG4105HEI LysR family (Transcriptional regulator PI93_RS16485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) PI93_RS16495 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) PI93_RS16505 ENOG4105VDB UPF0125 protein PI93_RS16510 ENOG4108Z1B Cyclase dehydrase PI93_RS16520 ENOG4107QX8 SPFH domain, Band 7 family protein PI93_RS16530 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) PI93_RS16535 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) PI93_RS16565 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) PI93_RS16575 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane PI93_RS16580 ENOG4105DZP Membrane-associated zinc metalloprotease PI93_RS16585 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) PI93_RS16590 ENOG4105KNE Phosphatidate cytidylyltransferase PI93_RS16595 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) PI93_RS16610 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) PI93_RS16615 ENOG4105CE9 30S ribosomal protein S2 PI93_RS16620 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) PI93_RS16630 ENOG4105FE9 pseudouridine synthase PI93_RS16635 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PI93_RS16640 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) PI93_RS16665 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) PI93_RS16670 ENOG4105KUZ arsenate reductase PI93_RS16675 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) PI93_RS16680 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) PI93_RS16690 ENOG4105C5H ABC transporter PI93_RS16695 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) PI93_RS16700 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) PI93_RS16705 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) PI93_RS16710 ENOG4105DWF phosphomethylpyrimidine kinase PI93_RS16720 ENOG4108UN4 phage SPO1 DNA polymerase-related protein PI93_RS16730 ENOG41072GX Peptidase M22 Glycoprotease PI93_RS16735 ENOG4105C1J atp-dependent rna helicase PI93_RS16745 ENOG4107QP3 malate synthase g PI93_RS16755 ENOG4105EJC lysr family transcriptional regulator PI93_RS16770 ENOG4107RT3 EamA-like transporter family PI93_RS16795 ENOG4108VAC response regulator PI93_RS16800 ENOG4108HRK Histidine kinase PI93_RS16810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit PI93_RS16820 ENOG4108ZAF Molybdopterin PI93_RS16825 ENOG4105M00 molybdopterin converting factor, subunit 1 PI93_RS16830 ENOG4105CVM Molybdenum cofactor synthesis domain protein PI93_RS16840 ENOG4105D6E homoserine dehydrogenase PI93_RS16845 ENOG4105CHM Aminotransferase PI93_RS16855 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) PI93_RS16865 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase PI93_RS16875 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) PI93_RS16880 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) PI93_RS16890 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen PI93_RS16895 ENOG4108IAB Phoh family PI93_RS16900 ENOG4105K4H Nlp p60 protein PI93_RS16910 ENOG4107QXV Phosphate transporter PI93_RS16920 ENOG4105CDU Replicative dna helicase PI93_RS16925 ENOG4105K9Q Binds to the 23S rRNA (By similarity) PI93_RS16930 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) PI93_RS16945 ENOG4105EJC lysr family transcriptional regulator PI93_RS16950 ENOG41060W2 glyoxylate carboligase PI93_RS16955 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) PI93_RS16960 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS16965 ENOG4105HDK L-asparaginase PI93_RS16970 ENOG4107R11 Transcriptional regulator PI93_RS16975 ENOG4108IJ6 ABC transporter PI93_RS16980 ENOG4105ECW sulfate abc transporter PI93_RS16985 ENOG4108I5D sulfate abc transporter PI93_RS16990 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein PI93_RS17030 ENOG4105CW7 secretion protein, HlyD family PI93_RS17035 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS17055 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) PI93_RS17060 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) PI93_RS17070 ENOG4105CHV Transcription elongation factor NusA PI93_RS17075 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) PI93_RS17080 ENOG4105FE9 pseudouridine synthase PI93_RS17085 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) PI93_RS17090 ENOG4105DS0 Transcriptional regulator, Crp Fnr family PI93_RS17100 ENOG4105EJC lysr family transcriptional regulator PI93_RS17105 ENOG4105CIS alcohol dehydrogenase PI93_RS17110 ENOG4105CEV competence damage-inducible protein PI93_RS17130 ENOG4105CQ7 ATP-dependent helicase PI93_RS17135 ENOG4108EKC n-acetylglutamate synthase PI93_RS17140 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) PI93_RS17150 ENOG4105E66 phosphoriboisomerase A PI93_RS17160 ENOG4105C2N RNA methyltransferase TrmH family group 3 PI93_RS17165 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) PI93_RS17175 ENOG4108FN7 Aldo keto reductase PI93_RS17180 ENOG410642W LysR family Transcriptional regulator PI93_RS17190 ENOG4105E7U AraC family transcriptional regulator PI93_RS17205 ENOG4105D7T ABC transporter PI93_RS17210 ENOG4105I5W Transporter PI93_RS17225 ENOG4105D6S protein involved in catabolism of external DNA PI93_RS17230 ENOG4108R3E Dna-3-methyladenine glycosylase i PI93_RS17235 ENOG4105CYX Short-chain dehydrogenase reductase Sdr PI93_RS17245 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr PI93_RS17250 ENOG4105JXH GntR family transcriptional regulator PI93_RS17270 ENOG4108R6K riboflavin synthase, subunit alpha PI93_RS17275 ENOG4105CGK Exodeoxyribonuclease III PI93_RS17295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PI93_RS17305 ENOG4105C5F glutamine synthetase PI93_RS17315 ENOG4108NIW Leucine export protein LeuE PI93_RS17370 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS17375 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) PI93_RS17380 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) PI93_RS17385 ENOG4105C4W S-formylglutathione hydrolase PI93_RS17425 ENOG4105RK9 auxin efflux carrier PI93_RS17430 ENOG4105BZU Histidine kinase PI93_RS17445 ENOG4105VEQ Cold shock protein PI93_RS17450 ENOG4105CHF Glutathione S-transferase PI93_RS17465 ENOG4107SPG Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR PI93_RS17525 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) PI93_RS17580 ENOG4108594 Permease of the drug metabolite transporter PI93_RS17585 ENOG4105K5X acetyltransferase PI93_RS17595 ENOG4105E09 nadh pyrophosphatase PI93_RS17600 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) PI93_RS17605 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate PI93_RS17610 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) PI93_RS17615 ENOG4105EAB amino acid AbC transporter PI93_RS17620 ENOG4105E5Q amino acid AbC transporter PI93_RS17625 ENOG4107QR9 Iron-sulfur cluster binding protein PI93_RS17640 ENOG41069M3 Transcriptional regulator PI93_RS17645 ENOG41061WM D-Alanyl-D-Alanine PI93_RS17655 ENOG4108IPJ Membrane PI93_RS17660 ENOG4105DGU Histone deacetylase PI93_RS17665 ENOG4108WFY phasin family PI93_RS17670 ENOG4107QN2 dihydrolipoyl dehydrogenase PI93_RS17680 ENOG4107QSN dihydrolipoamide acetyltransferase PI93_RS17685 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) PI93_RS17690 ENOG4105BZU Histidine kinase PI93_RS17695 ENOG4108ZXC Two component transcriptional regulator, luxr family PI93_RS17700 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) PI93_RS17705 ENOG4105DGW oligopeptidase A PI93_RS17715 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) PI93_RS17720 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis PI93_RS17725 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) PI93_RS17735 ENOG4105EPW hflc protein PI93_RS17740 ENOG4107QJR hflk protein PI93_RS17745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) PI93_RS17750 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) PI93_RS17755 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) PI93_RS17765 ENOG4105N21 Membrane PI93_RS17770 ENOG4105CUT histidyl-tRNA synthetase PI93_RS17775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) PI93_RS17790 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) PI93_RS17795 ENOG4108XRP Membrane PI93_RS17810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PI93_RS17815 ENOG4108K5P (LipO)protein PI93_RS17820 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) PI93_RS17825 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) PI93_RS17830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PI93_RS17840 ENOG4107UWC ABC, transporter PI93_RS17845 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS17895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family PI93_RS17905 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) PI93_RS17910 ENOG4107QMP dna polymerase iii subunits gamma and tau PI93_RS17920 ENOG4105K63 Thioredoxin PI93_RS17925 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) PI93_RS17940 ENOG4105D78 K07001 NTE family protein PI93_RS17945 ENOG4105K4H Nlp p60 protein PI93_RS17950 ENOG4108JQ5 ABC transporter PI93_RS17955 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component PI93_RS17960 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component PI93_RS17980 ENOG4108V1T peptidylprolyl cis-trans isomerase PI93_RS18040 ENOG4105CFH Aspartokinase PI93_RS18045 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) PI93_RS18050 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) PI93_RS18075 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) PI93_RS18080 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) PI93_RS18085 ENOG4105D7W serine acetyltransferase PI93_RS18095 ENOG4105ECY inositol monophosphatase PI93_RS18100 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) PI93_RS18115 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component PI93_RS18120 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) PI93_RS18125 ENOG4108UZX fmn reductase PI93_RS18135 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) PI93_RS18140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) PI93_RS18145 ENOG4105DIJ Phosphoethanolamine transferase PI93_RS18160 ENOG4105CIH Imidazole acetol-phosphate transaminase PI93_RS18165 ENOG4105C28 cystathionine PI93_RS18170 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase PI93_RS18185 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase PI93_RS18190 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) PI93_RS18195 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) PI93_RS18205 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) PI93_RS18210 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase PI93_RS18215 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) PI93_RS18225 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) PI93_RS18230 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) PI93_RS18235 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS18245 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS18250 ENOG4105BZN citrate synthase PI93_RS18255 ENOG41060IS Flavinator of succinate dehydrogenase PI93_RS18260 ENOG4105E33 succinate dehydrogenase PI93_RS18265 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) PI93_RS18280 ENOG4105FDP GntR family transcriptional regulator PI93_RS18285 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) PI93_RS18295 ENOG4107QM5 aconitate hydratase PI93_RS18315 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) PI93_RS18330 ENOG4105D1Q UPF0246 protein PI93_RS18340 ENOG4105CHM Aminotransferase PI93_RS18345 ENOG4105IU3 Glutathione S-transferase PI93_RS18355 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase PI93_RS18360 ENOG4108UKI Enoyl-CoA hydratase PI93_RS18375 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS18380 ENOG4105CYM Glutathione S-transferase PI93_RS18385 ENOG4105KWI UPF0339 protein PI93_RS18410 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PI93_RS18415 ENOG4105C8S subunit m PI93_RS18430 ENOG4105DF2 NADH dehydrogenase subunit j PI93_RS18435 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) PI93_RS18440 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) PI93_RS18450 ENOG4107QIZ NADH dehydrogenase PI93_RS18455 ENOG4105GKE subunit e PI93_RS18465 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain PI93_RS18475 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain PI93_RS18485 ENOG4107EJC Preprotein translocase subunit SecG PI93_RS18490 ENOG4105CP7 Triose-phosphate isomerase PI93_RS18505 ENOG4105BZU Histidine kinase PI93_RS18520 ENOG4108YZY peptidylprolyl cis-trans isomerase PI93_RS18525 ENOG4105EZE Cupin 4 family protein PI93_RS18540 ENOG4105GJM (LipO)protein PI93_RS18545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS18550 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) PI93_RS18555 ENOG4105C31 Tryptophanyl-tRNA synthetase PI93_RS18560 ENOG4108Z4T Peptidase M50 PI93_RS18565 ENOG4107RTD sua5 ycio yrdc ywlc family protein PI93_RS18570 ENOG4105DB7 PHP domain protein PI93_RS18580 ENOG4105ED9 Protein of unknown function (DUF455) PI93_RS18585 ENOG4108Z0R Transferase PI93_RS18590 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) PI93_RS18600 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) PI93_RS18605 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) PI93_RS18610 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase PI93_RS18615 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) PI93_RS18620 ENOG4108MUZ hydrolase PI93_RS18625 ENOG4108EC8 DNA internalization-related competence protein ComEC PI93_RS18630 ENOG4105EYA deoxyribonuclease PI93_RS18650 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) PI93_RS18655 ENOG4105EGI Transcriptional regulator PI93_RS18670 ENOG4108WN0 inhibitor of vertebrate lysozyme PI93_RS18675 ENOG4105CRK lysyL-tRNA synthetase PI93_RS18700 ENOG4105WVQ Fe-S assembly protein IscX PI93_RS18705 ENOG4108ZIT Ferredoxin, 2FE-2S PI93_RS18715 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) PI93_RS18725 ENOG4108Z4V iron-sulfur cluster assembly PI93_RS18730 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins PI93_RS18735 ENOG4105C3J Cysteine desulfurase PI93_RS18740 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family PI93_RS18750 ENOG4105KJF protein tyrosine phosphatase PI93_RS18760 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) PI93_RS18765 ENOG4105CGF Aromatic amino acid aminotransferase PI93_RS18775 ENOG4108W9H Tetr family transcriptional regulator PI93_RS18780 ENOG4108R3D Electron transport complex PI93_RS18785 ENOG4105CSM endonuclease III PI93_RS18790 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) PI93_RS18810 ENOG4106RE7 Cytochrome PI93_RS18815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) PI93_RS18825 ENOG4105DKK Benzoate PI93_RS18835 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) PI93_RS18870 ENOG4105T38 integral membrane protein PI93_RS18875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS18885 ENOG4105D94 Major Facilitator Superfamily PI93_RS18890 ENOG4106NZI LysR family Transcriptional regulator PI93_RS18900 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PI93_RS18905 ENOG4105E4C Lytic transglycosylase catalytic PI93_RS18915 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PI93_RS18920 ENOG4105C5H ABC transporter PI93_RS18925 ENOG4107YB6 acetyltransferase, (GNAT) family PI93_RS18945 ENOG4105CX6 glutaminyL-tRNA synthetase PI93_RS18970 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) PI93_RS18985 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS18990 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) PI93_RS19000 ENOG4108KB2 LysR family Transcriptional regulator PI93_RS19005 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component PI93_RS19010 ENOG4108UCS ABC, transporter PI93_RS19015 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) PI93_RS19030 ENOG4108IV0 ABC, transporter PI93_RS19035 ENOG4105C0Z ABC transporter PI93_RS19040 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PI93_RS19045 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS19055 ENOG4105CMS peptidase U62, modulator of DNA gyrase PI93_RS19060 ENOG4105N42 UPF0307 protein PI93_RS19065 ENOG4108RIR Molybdenum cofactor biosynthesis protein PI93_RS19070 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) PI93_RS19075 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 PI93_RS19080 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) PI93_RS19085 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) PI93_RS19090 ENOG4105P8F nudix hydrolase PI93_RS19095 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) PI93_RS19100 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) PI93_RS19105 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) PI93_RS19110 ENOG4105K5M 30s ribosomal protein S16 PI93_RS19115 ENOG4105DKB L-sorbosone dehydrogenase PI93_RS19140 ENOG4105EW9 transcriptional regulator AsnC family PI93_RS19145 ENOG4105MWK D-amino acid dehydrogenase, small subunit PI93_RS19150 ENOG4105DCF alanine dehydrogenase PI93_RS19155 ENOG4105BZS acriflavin resistance protein PI93_RS19160 ENOG4105ENT Efflux transporter rnd family, mfp subunit PI93_RS19165 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) PI93_RS19170 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) PI93_RS19195 ENOG4105ETT transcriptional Regulator, LysR family PI93_RS19200 ENOG4105F27 Major Facilitator PI93_RS19245 ENOG4107RGD Major Facilitator superfamily PI93_RS19250 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) PI93_RS19255 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) PI93_RS19335 ENOG4108FUF Transcriptional regulator, IclR family PI93_RS19340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS19345 ENOG4107YD3 Thioesterase PI93_RS19350 ENOG4105E02 MotA TolQ exbB proton channel PI93_RS19355 ENOG4108ZZF transport protein (ExbD) PI93_RS19365 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) PI93_RS19370 ENOG4105KCK Peptidoglycan-associated lipoprotein PI93_RS19445 ENOG4108RBT type iii secretion PI93_RS19470 ENOG4105YY8 Transcriptional regulator PI93_RS19475 ENOG4105K44 type iii secretion PI93_RS19490 ENOG4108HR8 type iii secretion PI93_RS19500 ENOG4108JIR Flagellum-specific ATP synthase PI93_RS19515 ENOG4105T85 surface presentation of antigens protein PI93_RS19520 ENOG41075IY surface presentation of antigens protein SpaP PI93_RS19530 ENOG4108TN6 type iii secretion PI93_RS19590 ENOG4105BZU Histidine kinase PI93_RS19615 ENOG4105C8S subunit m PI93_RS19625 ENOG4105C8S subunit m PI93_RS19645 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS19665 ENOG4107NQ8 LysR family Transcriptional regulator PI93_RS19670 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) PI93_RS19680 ENOG4105E98 transcriptional regulator DeoR family PI93_RS19690 ENOG4108Z9W Outer membrane porin PI93_RS19695 ENOG4108K01 transcriptional regulator PI93_RS19720 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS19725 ENOG4108IV0 ABC, transporter PI93_RS19730 ENOG4108IUZ ABC transporter PI93_RS19750 ENOG4105EFA 4-hydroxyphenylacetate PI93_RS19760 ENOG4105C3J Cysteine desulfurase PI93_RS19775 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic PI93_RS19785 ENOG4108SF5 RNA Polymerase PI93_RS19820 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) PI93_RS19835 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS19850 ENOG410829K Lysine exporter protein (Lyse ygga) PI93_RS19855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) PI93_RS19860 ENOG4105C85 amino acid PI93_RS19865 ENOG4108SU4 UPF0309 protein PI93_RS19880 ENOG4105EM7 Selenocysteine-specific translation elongation factor PI93_RS19890 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) PI93_RS19895 ENOG4108MG3 formate dehydrogenase PI93_RS19900 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein PI93_RS19915 ENOG4105F1S paraquat-inducible protein a PI93_RS19920 ENOG4105DY2 Paraquat-inducible protein b PI93_RS19935 ENOG4105WH1 Two component transcriptional regulator luxr family PI93_RS19945 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS19955 ENOG4105BZP glycoside hydrolase 15-related PI93_RS19960 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS19965 ENOG4105E39 Enoyl-CoA hydratase PI93_RS19975 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS19990 ENOG4108M0I Transcriptional regulator PI93_RS19995 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PI93_RS20000 ENOG4105W8H transhydrogenase (subunit alpha PI93_RS20005 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) PI93_RS20010 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 PI93_RS20015 ENOG4105DUM transcriptional regulator, lysR family PI93_RS20025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F PI93_RS20030 ENOG4105BZU Histidine kinase PI93_RS20040 ENOG4105CFN oxalyl-CoA decarboxylase PI93_RS20045 ENOG4105FCD Major Facilitator PI93_RS20050 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) PI93_RS20060 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS20065 ENOG4105GKE subunit e PI93_RS20070 ENOG4107QIZ NADH dehydrogenase PI93_RS20075 ENOG4108IEG Formate dehydrogenase Alpha subunit PI93_RS20125 ENOG4107R73 Mate efflux family protein PI93_RS20145 ENOG4107YZX Universal stress protein PI93_RS20155 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component PI93_RS20160 ENOG4105BZ7 extracellular solute-binding protein family 1 PI93_RS20190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS20195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PI93_RS20200 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS20205 ENOG4108JQ6 ABC transporter PI93_RS20210 ENOG4105D44 asparaginase PI93_RS20225 ENOG4108VIA integral membrane protein PI93_RS20230 ENOG4105E39 Enoyl-CoA hydratase PI93_RS20235 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS20250 ENOG4108ZX5 transcriptional regulator PI93_RS20260 ENOG4108Z9W Outer membrane porin PI93_RS20265 ENOG4108K2P TRANSCRIPTIONal PI93_RS20275 ENOG4105D5U fad dependent oxidoreductase PI93_RS20280 ENOG4105C10 Electron transfer flavoprotein PI93_RS20285 ENOG4105BZJ Electron transfer flavoprotein PI93_RS20290 ENOG4107RGD Major Facilitator superfamily PI93_RS20300 ENOG4105CQB FAD linked oxidase domain protein PI93_RS20305 ENOG4108QBF Transcriptional regulator PI93_RS20325 ENOG4105EQ0 Major Facilitator superfamily PI93_RS20345 ENOG4107258 Transcriptional regulator PI93_RS20350 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) PI93_RS20355 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) PI93_RS20360 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) PI93_RS20380 ENOG4105CT1 (ABC) transporter PI93_RS20385 ENOG4105NTW Transcriptional regulator PI93_RS20390 ENOG4105Q26 Siderophore-interacting protein PI93_RS20405 ENOG410904N short-chain dehydrogenase reductase PI93_RS20420 ENOG4108S0S Nucleotidyl transferase PI93_RS20430 ENOG4105DTI Phosphonopyruvate decarboxylase PI93_RS20440 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) PI93_RS20455 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) PI93_RS20470 ENOG41076QQ Glycosyl transferase, family 2 PI93_RS20480 ENOG4105EWU Squalene--hopene cyclase PI93_RS20485 ENOG4107S11 squalene-associated FAD-dependent desaturase PI93_RS20490 ENOG4105FE1 phytoene synthase PI93_RS20505 ENOG4105EA8 2-Nitropropane dioxygenase PI93_RS20510 ENOG4105C26 Dehydrogenase PI93_RS20515 ENOG4108JPW Aminotransferase PI93_RS20545 ENOG4108Z9W Outer membrane porin PI93_RS20550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS20560 ENOG4105D81 ABC transporter, permease PI93_RS20575 ENOG4107HP6 Transcriptional regulator PI93_RS20595 ENOG4105CCU oxidase (Subunit III) PI93_RS20600 ENOG4105BZ9 Cytochrome C oxidase, subunit I PI93_RS20605 ENOG4105E2S oxidase) subunit II PI93_RS20620 ENOG4108KXV response regulator PI93_RS20625 ENOG4105BZU Histidine kinase PI93_RS20630 ENOG4105ENJ RND efflux system, outer membrane lipoprotein PI93_RS20640 ENOG4105DJY efflux transporter, rnd family, mfp subunit PI93_RS20645 ENOG4105EN6 Membrane PI93_RS20665 ENOG410904A RNA polymerase PI93_RS20675 ENOG4105BZN citrate synthase PI93_RS20680 ENOG4105D2S major facilitator superfamily PI93_RS20685 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase PI93_RS20690 ENOG4108S8N class II Aldolase PI93_RS20695 ENOG4105CRW Short chain fatty acid transporter PI93_RS20700 ENOG4105CIF Ornithine Cyclodeaminase PI93_RS20705 ENOG4107QY8 reductase PI93_RS20730 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS20740 ENOG4105GVF (ABC) transporter PI93_RS20750 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase PI93_RS20755 ENOG4108MP6 LysR family Transcriptional regulator PI93_RS20760 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS20770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS20775 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component PI93_RS20785 ENOG4108Z9W Outer membrane porin PI93_RS20820 ENOG4105GVF (ABC) transporter PI93_RS20825 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) PI93_RS20830 ENOG4108KPJ rna polymerase sigma factor PI93_RS20840 ENOG4105EJC lysr family transcriptional regulator PI93_RS20845 ENOG4108ZHJ Organic hydroperoxide resistance protein PI93_RS20880 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS20885 ENOG4108IY8 ABC, transporter PI93_RS20910 ENOG41073TP transcriptional regulator PI93_RS20915 ENOG4105D01 (LipO)protein PI93_RS20955 ENOG4105C7J ABC transporter, permease PI93_RS20960 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS20980 ENOG4108Z9W Outer membrane porin PI93_RS21070 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS21075 ENOG4108ZJF Glcg protein PI93_RS21090 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase PI93_RS21095 ENOG41064T2 transcriptional regulator, lysR family PI93_RS21110 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme PI93_RS21125 ENOG4105C26 Dehydrogenase PI93_RS21145 ENOG4105D25 secreted protein PI93_RS21175 ENOG4105CHR reductase PI93_RS21180 ENOG4105CHU acetyl-coa acetyltransferase PI93_RS21185 ENOG4105EUJ GTP cyclohydrolase i PI93_RS21195 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS21200 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr PI93_RS21215 ENOG4108ETT Dehydrogenase PI93_RS21240 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS21245 ENOG4105CC9 acyl-Coa dehydrogenase PI93_RS21250 ENOG4105D2B acyl-CoA dehydrogenase PI93_RS21275 ENOG4105CHR reductase PI93_RS21285 ENOG4105C10 Electron transfer flavoprotein PI93_RS21290 ENOG4105BZJ Electron transfer flavoprotein PI93_RS21305 ENOG4105ERH Fumarylacetoacetate hydrolase PI93_RS21315 ENOG41061TZ Short-chain dehydrogenase reductase Sdr PI93_RS21325 ENOG4107Z7P Ferredoxin PI93_RS21330 ENOG4108JGH Tetr family transcriptional regulator PI93_RS21340 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr PI93_RS21350 ENOG4105C10 Electron transfer flavoprotein PI93_RS21355 ENOG4105BZJ Electron transfer flavoprotein PI93_RS21360 ENOG4105C1G acyl-Coa dehydrogenase PI93_RS21370 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase PI93_RS21380 ENOG4105C6F GntR Family Transcriptional Regulator PI93_RS21405 ENOG4105FUY alpha subunit PI93_RS21415 ENOG41090TK Short-chain dehydrogenase reductase Sdr PI93_RS21425 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS21435 ENOG4105CIH Imidazole acetol-phosphate transaminase PI93_RS21445 ENOG4107SQD Transcriptional regulator, GntR family PI93_RS21450 ENOG4105CDA abc transporter atp-binding protein PI93_RS21455 ENOG4105DRP amino acid AbC transporter PI93_RS21460 ENOG4105EAD ABC transporter PI93_RS21465 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS21470 ENOG4107U9B transcriptional regulator PI93_RS21475 ENOG4105C7W Xanthine dehydrogenase PI93_RS21480 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding PI93_RS21485 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit PI93_RS21505 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS21510 ENOG4107RP9 extracellular solute-binding protein, family 3 PI93_RS21520 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) PI93_RS21525 ENOG4105D1H recombination factor protein RarA PI93_RS21530 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) PI93_RS21535 ENOG4105CNU cell division protein FtsK PI93_RS21540 ENOG4105C3M thioredoxin reductase PI93_RS21545 ENOG4105C98 muts2 protein PI93_RS21550 ENOG4105EN6 Membrane PI93_RS21555 ENOG4108YZA Nitrogen regulatory protein pii PI93_RS21570 ENOG4105DYS nad(p)h dehydrogenase (quinone) PI93_RS21580 ENOG4105F0N pyrophosphate phospho-hydrolase PI93_RS21595 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS21600 ENOG4105F38 ABC transporter, permease PI93_RS21615 ENOG4105CQB FAD linked oxidase domain protein PI93_RS21630 ENOG4105CSP Major Facilitator Superfamily PI93_RS21635 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS21655 ENOG41076E6 Uroporphyrinogen-III Synthase PI93_RS21660 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) PI93_RS21675 ENOG4105CH7 arginosuccinase PI93_RS21680 ENOG4105D6U Sodium Glutamate Symporter PI93_RS21685 ENOG4105CXN decarboxylase PI93_RS21690 ENOG4105DHP deoxycytidine triphosphate deaminase PI93_RS21695 ENOG4105D1F ATP-binding protein PI93_RS21700 ENOG4108ZG0 Ompa motb domain protein PI93_RS21705 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) PI93_RS21710 ENOG4105DMQ Methyltransferase PI93_RS21715 ENOG4108XM1 transcriptional regulator AsnC family PI93_RS21730 ENOG4105MA0 exported protein PI93_RS21750 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) PI93_RS21755 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) PI93_RS21760 ENOG4105D1F ATP-binding protein PI93_RS21765 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) PI93_RS21770 ENOG4108YZT Adenosylcobinamide kinase PI93_RS21775 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) PI93_RS21780 ENOG4105EFT decarboxylase PI93_RS21795 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) PI93_RS21800 ENOG4107TB6 phosphoglycerate mutase PI93_RS21805 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) PI93_RS21810 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) PI93_RS21815 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase PI93_RS21820 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) PI93_RS21825 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) PI93_RS21830 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) PI93_RS21850 ENOG4105CSU acyl-Coa dehydrogenase PI93_RS21855 ENOG4105C10 Electron transfer flavoprotein PI93_RS21860 ENOG4105BZJ Electron transfer flavoprotein PI93_RS21870 ENOG4105DP0 ferredoxin-NADP reductase PI93_RS21885 ENOG4105CVE Lytic murein transglycosylase PI93_RS21890 ENOG4105C6T cysteine synthase PI93_RS21905 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) PI93_RS21910 ENOG4105C6Y Udp-glucose 6-dehydrogenase PI93_RS21915 ENOG4105CFV Tetratricopeptide repeat protein PI93_RS21925 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) PI93_RS21930 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) PI93_RS21935 ENOG4105CAT Cytidine monophosphate kinase PI93_RS21940 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) PI93_RS21960 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) PI93_RS21970 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) PI93_RS21975 ENOG4105UYK outer membrane protein a PI93_RS21995 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS22000 ENOG4105E39 Enoyl-CoA hydratase PI93_RS22010 ENOG4105CG6 trap dicarboxylate transporter dctm subunit PI93_RS22020 ENOG41085JF Trap dicarboxylate transporter-dctp subunit PI93_RS22025 ENOG4105DRR Transcriptional regulator, GntR family PI93_RS22030 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) PI93_RS22035 ENOG4106NZI LysR family Transcriptional regulator PI93_RS22040 ENOG4105C01 Dihydroxy-acid dehydratase PI93_RS22055 ENOG4105J12 Multidrug resistance protein mdtN PI93_RS22060 ENOG4108MI0 Resistance protein PI93_RS22080 ENOG4105MYG DNA polymerase iii, chi subunit PI93_RS22085 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) PI93_RS22090 ENOG4108M8S permease YjgP YjgQ family protein PI93_RS22095 ENOG4108K5H permease YjgP YjgQ family protein PI93_RS22105 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) PI93_RS22110 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) PI93_RS22125 ENOG4107TSN permease PI93_RS22130 ENOG4107R11 Transcriptional regulator PI93_RS22145 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase PI93_RS22175 ENOG4105H3G oxidoreductase PI93_RS22185 ENOG41061H0 Monooxygenase PI93_RS22210 ENOG4108V06 Glutathione peroxidase PI93_RS22225 ENOG4105KME endoribonuclease L-psp PI93_RS22245 ENOG4107XKF NMT1 THI5 Like Domain Protein PI93_RS22250 ENOG4105C26 Dehydrogenase PI93_RS22260 ENOG4105C7K acetolactate synthase PI93_RS22270 ENOG4107258 Transcriptional regulator PI93_RS22290 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component PI93_RS22305 ENOG4105MSY salicylate hydroxylase PI93_RS22325 ENOG4108ZHR arsR family transcriptional regulator PI93_RS22335 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS22340 ENOG4105R8A Heat shock protein PI93_RS22345 ENOG4105C6Z Gluconate PI93_RS22350 ENOG4105FYV Amp nucleosidase PI93_RS22355 ENOG4105WKW Pfam:DUF1458 PI93_RS22360 ENOG4108ZT1 Transcriptional regulator PI93_RS22365 ENOG4105CHC glucokinase (EC 2.7.1.2) PI93_RS22375 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase PI93_RS22380 ENOG4105C01 Dihydroxy-acid dehydratase PI93_RS22390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) PI93_RS22410 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic PI93_RS22420 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase PI93_RS22425 ENOG4105NXH GreA GreB family elongation factor PI93_RS22430 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase PI93_RS22435 ENOG4108V0P LemA family PI93_RS22450 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) PI93_RS22475 ENOG4105CP9 extracellular ligand-binding receptor PI93_RS22480 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS22485 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PI93_RS22490 ENOG4105C0Z ABC transporter PI93_RS22495 ENOG4108IV0 ABC, transporter PI93_RS22505 ENOG41082BM Transcriptional regulator, arsr family PI93_RS22515 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) PI93_RS22520 ENOG4107YIM Involved in the transcription termination process (By similarity) PI93_RS22535 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) PI93_RS22540 ENOG4105C26 Dehydrogenase PI93_RS22545 ENOG4107QTZ amino acid PI93_RS22550 ENOG4105BZU Histidine kinase PI93_RS22555 ENOG4105D01 (LipO)protein PI93_RS22560 ENOG4108UMI ABC transporter, permease PI93_RS22565 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS22570 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) PI93_RS22575 ENOG4105WH1 Two component transcriptional regulator luxr family PI93_RS22595 ENOG4105BZU Histidine kinase PI93_RS22600 ENOG4105VDW Csbd family PI93_RS22620 ENOG4108NVR Methyl-accepting chemotaxis PI93_RS22640 ENOG4105DUM transcriptional regulator, lysR family PI93_RS22655 ENOG4107EXC regulatoR PI93_RS22660 ENOG4105JJR Histidine kinase PI93_RS22665 ENOG4108Z9W Outer membrane porin PI93_RS22670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS22680 ENOG4105E0C molybdate abc transporter PI93_RS22695 ENOG4105DD5 Flagellar motor switch protein PI93_RS22700 ENOG4105CN7 Flagellar biosynthetic protein FliP PI93_RS22705 ENOG4105VS8 Flagellar biosynthetic protein fliq PI93_RS22710 ENOG4105D19 Role in flagellar biosynthesis (By similarity) PI93_RS22715 ENOG4105D00 flagellar biosynthetic protein flhB PI93_RS22755 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) PI93_RS22760 ENOG4105CGA flagellar basal-body rod protein FlgG PI93_RS22765 ENOG4105KTQ flagellar basal-body rod protein PI93_RS22770 ENOG4105BZE flagellar hook protein, FlgE PI93_RS22780 ENOG4108ZC9 flagellar basal-body rod protein flgc PI93_RS22785 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) PI93_RS22805 ENOG4107RD7 Flagellar Motor Protein, MotA PI93_RS22840 ENOG4108JIR Flagellum-specific ATP synthase PI93_RS22850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) PI93_RS22855 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) PI93_RS22860 ENOG4108JU3 Alkyl hydroperoxide reductase PI93_RS22865 ENOG4105D3R alkyl hydroperoxide reductase PI93_RS22895 ENOG4108Z9W Outer membrane porin PI93_RS22920 ENOG4105D2S major facilitator superfamily PI93_RS22930 ENOG4105W4W Transcriptional regulator PI93_RS22935 ENOG4105F2Z 3-oxoadipate enol-lactonase PI93_RS22940 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase PI93_RS22945 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase PI93_RS22960 ENOG4105DDW LysR family Transcriptional regulator PI93_RS22970 ENOG4105CSU acyl-Coa dehydrogenase PI93_RS22985 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase PI93_RS22990 ENOG4108Z9W Outer membrane porin PI93_RS22995 ENOG4108SC4 )-transporter PI93_RS23005 ENOG4108VYJ response regulator receiver protein PI93_RS23020 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS23025 ENOG4105CBS Chea signal transduction histidine kinase PI93_RS23030 ENOG4108M0I Transcriptional regulator PI93_RS23035 ENOG41061H0 Monooxygenase PI93_RS23040 ENOG4105D2S major facilitator superfamily PI93_RS23045 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) PI93_RS23050 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component PI93_RS23055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component PI93_RS23060 ENOG4105DEF Extracellular solute-binding protein, family 5 PI93_RS23065 ENOG4108JQ7 (ABC) transporter PI93_RS23070 ENOG4105C3U ABC transporter PI93_RS23075 ENOG4105DUM transcriptional regulator, lysR family PI93_RS23080 ENOG4105CSH Transporter PI93_RS23085 ENOG4105E2S oxidase) subunit II PI93_RS23090 ENOG4105BZ9 Cytochrome C oxidase, subunit I PI93_RS23095 ENOG4105CCU oxidase (Subunit III) PI93_RS23100 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) PI93_RS23110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family PI93_RS23125 ENOG4108UMI ABC transporter, permease PI93_RS23130 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) PI93_RS23135 ENOG4105D01 (LipO)protein PI93_RS23140 ENOG41061WM D-Alanyl-D-Alanine PI93_RS23145 ENOG4105C57 major facilitator superfamily PI93_RS23150 ENOG4105EPD Oligopeptide transporter, Opt family PI93_RS23180 ENOG4107RZC phospholipase d PI93_RS23190 ENOG4108S3W Anti-feci sigma factor, fecr PI93_RS23210 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit PI93_RS23215 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit PI93_RS23220 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit PI93_RS23225 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit PI93_RS23230 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) PI93_RS23250 ENOG4108XM1 transcriptional regulator AsnC family PI93_RS23265 ENOG4105C6K Malic enzyme PI93_RS23270 ENOG4107RGD Major Facilitator superfamily PI93_RS23275 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) PI93_RS23280 ENOG4107Z6W Protein CrcB homolog PI93_RS23290 ENOG4105F2W methyltransferase PI93_RS23320 ENOG4108Z0R Transferase PI93_RS23325 ENOG4105C09 Bile acid PI93_RS23330 ENOG4105C1J atp-dependent rna helicase PI93_RS23335 ENOG4105C5Q Transcriptional regulator PI93_RS23340 ENOG4105C2W permease PI93_RS23355 ENOG4107S1E Beta-lactamase PI93_RS23360 ENOG41082IR Excinuclease ABC C subunit domain protein PI93_RS23380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer PI93_RS23425 ENOG4107RGD Major Facilitator superfamily PI93_RS23430 ENOG4105CFM UPF0317 protein PI93_RS23435 ENOG4105CR8 Transcriptional regulator PI93_RS23445 ENOG4105CCU oxidase (Subunit III) PI93_RS23450 ENOG4105CCU oxidase (Subunit III) PI93_RS23460 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) PI93_RS23495 ENOG4105C30 Nad-dependent epimerase dehydratase PI93_RS23505 ENOG4108EX3 reductase PI93_RS23510 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase PI93_RS23515 ENOG4105FAW cDP-glucose 4,6-dehydratase PI93_RS23520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase PI93_RS23525 ENOG4108SMP Nad-dependent epimerase dehydratase PI93_RS23565 ENOG4108UW5 maltose o-acetyltransferase PI93_RS23570 ENOG4108TMJ glycosyl transferase PI93_RS23600 ENOG4105CGH 5'-nucleotidase PI93_RS23610 ENOG4108XRS Monoheme cytochrome SoxX (Sulfur oxidation) PI93_RS23630 ENOG4105W2Z cytochrome C, class I PI93_RS23635 ENOG4105W2Z cytochrome C, class I PI93_RS23640 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) PI93_RS23655 ENOG4107S7U Sulfide dehydrogenase PI93_RS23665 ENOG4105W4M Transport-associated protein PI93_RS23670 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) PI93_RS23675 ENOG41082RQ UPF0102 protein PI93_RS23680 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) PI93_RS23685 ENOG4108JJB ABC transporter PI93_RS23705 ENOG4105C5X domain protein PI93_RS23730 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) PI93_RS23735 ENOG4105K4P CoA-binding domain protein PI93_RS23745 ENOG4105F87 Dehydratase PI93_RS23750 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) PI93_RS23755 ENOG4105C25 Primosomal protein n' PI93_RS23770 ENOG4105C26 Dehydrogenase PI93_RS23775 ENOG4105CK7 Sodium proline symporter PI93_RS23790 ENOG4105BZG amino acid carrier protein PI93_RS23805 ENOG4105EJQ L-serine dehydratase PI93_RS23810 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor PI93_RS23815 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) PI93_RS23820 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) PI93_RS23830 ENOG4105C4R Atp-dependent dna helicase PI93_RS23840 ENOG4105MPD Cytochrome PI93_RS23870 ENOG4105JHE Major Facilitator Superfamily PI93_RS23880 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) PI93_RS23885 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) PI93_RS23890 ENOG4105JSC dimethylmenaquinone methyltransferase PI93_RS23900 ENOG4105CKI cobalamin synthesis protein PI93_RS23905 ENOG4108K3M Rieske [2Fe-2S] domain PI93_RS23920 ENOG4105KHM amidohydrolase 2 PI93_RS23945 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) PI93_RS23950 ENOG4105EB3 Histidine kinase PI93_RS23955 ENOG4105E3W Two component transcriptional regulator (Winged helix family PI93_RS23970 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component PI93_RS23980 ENOG4105D2X ABC transporter substrate-binding protein PI93_RS23985 ENOG4105XJC Two component transcriptional regulator (Winged helix family PI93_RS23995 ENOG4105BZU Histidine kinase PI93_RS24000 ENOG4105WH1 Two component transcriptional regulator luxr family PI93_RS24010 ENOG4105DTS flagellar hook-associated PI93_RS24015 ENOG4105MQ3 flagellar protein FliS PI93_RS24020 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) PI93_RS24030 ENOG4105VM1 flagellar PI93_RS24045 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) PI93_RS24050 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) PI93_RS24055 ENOG41090PJ Flagellar assembly protein PI93_RS24060 ENOG4108JIR Flagellum-specific ATP synthase PI93_RS24065 ENOG4105GSA Flagellar export protein flij PI93_RS24070 ENOG4105WF4 Flagellar hook-length control protein PI93_RS24075 ENOG4107ZI8 flagellar basal body-associated protein flil PI93_RS24080 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) PI93_RS24085 ENOG4105DD5 Flagellar motor switch protein PI93_RS24090 ENOG4105VTB flagellar biosynthesis protein fliO PI93_RS24095 ENOG4105CN7 Flagellar biosynthetic protein FliP PI93_RS24100 ENOG4105VS8 Flagellar biosynthetic protein fliq PI93_RS24105 ENOG4105D19 Role in flagellar biosynthesis (By similarity) PI93_RS24110 ENOG4105DTJ flagellar hook-associated protein PI93_RS24115 ENOG4105E1Q flagellar hook-associated protein PI93_RS24120 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj PI93_RS24125 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) PI93_RS24130 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) PI93_RS24135 ENOG4105CGA flagellar basal-body rod protein FlgG PI93_RS24140 ENOG4108KPB Flagellar basal-body rod protein FlgF PI93_RS24145 ENOG4105BZE flagellar hook protein, FlgE PI93_RS24150 ENOG4105W00 Flagellar hook capping protein PI93_RS24155 ENOG4108ZC9 flagellar basal-body rod protein flgc PI93_RS24160 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) PI93_RS24190 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase PI93_RS24195 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) PI93_RS24205 ENOG4105FZW flagellar biosynthesis regulator FlhF PI93_RS24210 ENOG4105D7B Flagellar biosynthesis protein flha PI93_RS24215 ENOG4105D00 flagellar biosynthetic protein flhB PI93_RS24220 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) PI93_RS24225 ENOG4108VYJ response regulator receiver protein PI93_RS24240 ENOG4105BZU Histidine kinase PI93_RS24245 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS24250 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS24255 ENOG4105C8Q Methyl-accepting chemotaxis PI93_RS24260 ENOG4108V3W Chemotaxis protein, CheW PI93_RS24265 ENOG4105CBS Chea signal transduction histidine kinase PI93_RS24270 ENOG4105BZU Histidine kinase PI93_RS24275 ENOG4105ER2 Ompa motb domain protein PI93_RS24280 ENOG4107RD7 Flagellar Motor Protein, MotA PI93_RS24285 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region PI93_RS24290 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) PI93_RS24295 ENOG4105C2C drug resistance transporter, Bcr CflA PI93_RS24300 ENOG4105CEY Amp-dependent synthetase and ligase PI93_RS24305 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) PI93_RS24310 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) PI93_RS24315 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) PI93_RS24330 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) PI93_RS24335 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) PI93_RS24340 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) PI93_RS24350 ENOG4105F4P )-transporter PI93_RS24355 ENOG4105FA0 parb-like partition protein PI93_RS24360 ENOG4107QJE Chromosome Partitioning Protein PI93_RS24365 ENOG4105QNF Outer membrane lipoprotein PI93_RS24370 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) PI93_RS24375 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) PI93_RS24380 ENOG4108IV0 ABC, transporter PI93_RS24385 ENOG4105C0Z ABC transporter PI93_RS24395 ENOG4108V8F Transcriptional regulator, MarR family PI93_RS24410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease PI93_RS24415 ENOG4105C32 Amino acid ABC transporter (Permease) PI93_RS24425 ENOG4108IV0 ABC, transporter PI93_RS24430 ENOG4105C0Z ABC transporter PI93_RS24440 ENOG4108YRB methyltransferase PI93_RS24455 ENOG4105CN8 Transcriptional regulator PI93_RS24460 ENOG4105C9Q fumarate hydratase class II PI93_RS24465 ENOG4105EQ2 LysR family Transcriptional regulator PI93_RS24470 ENOG4105CSH Transporter PI93_RS24500 ENOG4108YXU transcriptional regulator AsnC family PI93_RS24505 ENOG4105D05 Receptor PI93_RS24510 ENOG4106QJH hemin transport protein PI93_RS24515 ENOG4107R4I Periplasmic binding protein PI93_RS24520 ENOG4105EHG Permease protein PI93_RS24530 ENOG4105F84 Ornithine cyclodeaminase PI93_RS24535 ENOG4105BZ4 penicillin-binding protein PI93_RS24555 ENOG4108YXU transcriptional regulator AsnC family PI93_RS24560 ENOG4105MIR Phenylalanine 4-monooxygenase PI93_RS24565 ENOG4105KZX Pterin carbinolamine dehydratase PI93_RS24590 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) PI93_RS24600 ENOG4105K56 Transcriptional regulator PI93_RS24610 ENOG4105C0R drug resistance transporter emrb qaca subfamily PI93_RS24645 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) PI93_RS24660 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) PI93_RS24665 ENOG4105VG0 50S ribosomal protein l34