locus-tag	class	description
PI93_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PI93_RS00065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PI93_RS00090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PI93_RS00115	COG2271	Major facilitator Superfamily
PI93_RS00120	COG0477	Major facilitator Superfamily
PI93_RS00125	COG0583	DNA-binding transcription factor activity
PI93_RS00135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI93_RS00135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI93_RS00155	COG3618	amidohydrolase
PI93_RS00165	COG0583	DNA-binding transcription factor activity
PI93_RS00175	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS00180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI93_RS00195	COG0583	DNA-binding transcription factor activity
PI93_RS00210	COG0833	amino acid
PI93_RS00225	COG1396	sequence-specific DNA binding
PI93_RS00230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS00240	COG0583	DNA-binding transcription factor activity
PI93_RS00250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PI93_RS00270	COG0477	Major facilitator Superfamily
PI93_RS00275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS00280	COG1802	Transcriptional regulator
PI93_RS00300	COG0410	ABC transporter
PI93_RS00330	COG0840	transmembrane signaling receptor activity
PI93_RS00355	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PI93_RS00365	COG0583	DNA-binding transcription factor activity
PI93_RS00375	COG0765	amino acid transport
PI93_RS00380	COG0765	amino acid transport
PI93_RS00415	COG1252	NADH dehydrogenase
PI93_RS00420	COG1309	transcriptional regulator
PI93_RS00435	COG4774	siderophore transport
PI93_RS00440	COG3712	iron ion homeostasis
PI93_RS00450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PI93_RS00470	COG1968	undecaprenyl-diphosphatase activity
PI93_RS00475	COG0583	DNA-binding transcription factor activity
PI93_RS00505	COG2252	PERMEase
PI93_RS00510	COG0583	DNA-binding transcription factor activity
PI93_RS00525	COG2733	membrane
PI93_RS00530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PI93_RS00560	COG0583	DNA-binding transcription factor activity
PI93_RS00570	COG0583	DNA-binding transcription factor activity
PI93_RS00585	COG0583	DNA-binding transcription factor activity
PI93_RS00590	COG2814	Major facilitator Superfamily
PI93_RS00600	COG2200	EAL domain
PI93_RS00600	COG2771	luxR family
PI93_RS00605	COG2223	nitrite transmembrane transporter activity
PI93_RS00630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PI93_RS00635	COG3246	L-lysine catabolic process to acetate
PI93_RS00640	COG0840	transmembrane signaling receptor activity
PI93_RS00650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PI93_RS00650	COG0457	Tetratricopeptide repeat
PI93_RS00655	COG0835	chemotaxis
PI93_RS00670	COG2203	Gaf domain
PI93_RS00670	COG3706	GGDEF domain
PI93_RS00670	COG4251	negative regulation of phosphorylation
PI93_RS00670	COG5001	Diguanylate cyclase
PI93_RS00705	COG1473	amidohydrolase
PI93_RS00740	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS00750	COG1802	Transcriptional regulator
PI93_RS00760	COG1672	PFAM Archaeal ATPase
PI93_RS00760	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
PI93_RS00765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS00770	COG4774	siderophore transport
PI93_RS00775	COG3128	pkhd-type hydroxylase
PI93_RS00805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PI93_RS00810	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PI93_RS00830	COG1966	Carbon starvation protein
PI93_RS00835	COG2879	small protein
PI93_RS00845	COG0583	DNA-binding transcription factor activity
PI93_RS00860	COG0758	DNA mediated transformation
PI93_RS00860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PI93_RS00865	COG0242	peptide deformylase activity
PI93_RS00875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PI93_RS00880	COG0501	Belongs to the peptidase M48B family
PI93_RS00885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI93_RS00885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PI93_RS00895	COG5000	phosphorelay sensor kinase activity
PI93_RS00900	COG2204	response regulator
PI93_RS00900	COG2204	response regulator
PI93_RS00915	COG0602	queuosine metabolic process
PI93_RS00920	COG0720	synthase
PI93_RS00940	COG0772	Belongs to the SEDS family
PI93_RS00945	COG0768	penicillin binding
PI93_RS00955	COG1792	Involved in formation and maintenance of cell shape
PI93_RS00960	COG1077	Cell shape determining protein MreB Mrl
PI93_RS00965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PI93_RS00980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PI93_RS00985	COG2326	polyphosphate kinase activity
PI93_RS00990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS01045	COG1960	acyl-CoA dehydrogenase activity
PI93_RS01060	COG1560	Kdo2-lipid A biosynthetic process
PI93_RS01065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PI93_RS01075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PI93_RS01080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PI93_RS01095	COG0523	cobalamin synthesis protein
PI93_RS01100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PI93_RS01110	COG4206	TonB-dependent receptor
PI93_RS01115	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PI93_RS01120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PI93_RS01125	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PI93_RS01145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PI93_RS01170	COG0477	Major facilitator Superfamily
PI93_RS01205	COG0683	leucine binding
PI93_RS01225	COG0410	ABC transporter
PI93_RS01230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PI93_RS01235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI93_RS01240	COG2828	Protein conserved in bacteria
PI93_RS01255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS01260	COG2814	Major facilitator Superfamily
PI93_RS01270	COG1309	transcriptional regulator
PI93_RS01275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PI93_RS01280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PI93_RS01280	COG2813	Specifically methylates the guanine in position
PI93_RS01285	COG2814	Major facilitator Superfamily
PI93_RS01295	COG0708	Exodeoxyribonuclease III
PI93_RS01300	COG0583	DNA-binding transcription factor activity
PI93_RS01305	COG1380	Effector of murein hydrolase LrgA
PI93_RS01310	COG1346	cytolysis
PI93_RS01315	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PI93_RS01320	COG1950	PFAM Membrane protein of
PI93_RS01325	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PI93_RS01330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PI93_RS01335	COG0747	negative chemotaxis
PI93_RS01340	COG0601	transmembrane transport
PI93_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI93_RS01350	COG0444	Belongs to the ABC transporter superfamily
PI93_RS01355	COG4608	Belongs to the ABC transporter superfamily
PI93_RS01365	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PI93_RS01370	COG0830	nickel cation binding
PI93_RS01380	COG0804	urea catabolic process
PI93_RS01385	COG0832	Belongs to the urease beta subunit family
PI93_RS01395	COG0831	urea catabolic process
PI93_RS01400	COG1126	abc transporter atp-binding protein
PI93_RS01410	COG0765	amino acid transport
PI93_RS01415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS01430	COG0411	ABC transporter
PI93_RS01440	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS01450	COG2814	Major facilitator Superfamily
PI93_RS01460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS01475	COG1984	allophanate hydrolase subunit 2
PI93_RS01480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PI93_RS01500	COG0625	glutathione transferase activity
PI93_RS01505	COG0617	tRNA 3'-terminal CCA addition
PI93_RS01545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PI93_RS01550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PI93_RS01555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI93_RS01560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS01570	COG1104	cysteine desulfurase activity
PI93_RS01620	COG0137	argininosuccinate synthase activity
PI93_RS01625	COG0583	DNA-binding transcription factor activity
PI93_RS01640	COG0625	glutathione transferase activity
PI93_RS01645	COG0583	DNA-binding transcription factor activity
PI93_RS01675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS01690	COG0583	DNA-binding transcription factor activity
PI93_RS01715	COG2169	Transcriptional regulator
PI93_RS01715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PI93_RS01730	COG0523	cobalamin synthesis protein
PI93_RS01740	COG1741	Belongs to the pirin family
PI93_RS01750	COG1739	Uncharacterized protein family UPF0029
PI93_RS01760	COG2132	Multicopper oxidase
PI93_RS01800	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI93_RS01865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PI93_RS01870	COG4681	YaeQ
PI93_RS01890	COG0697	spore germination
PI93_RS01905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS01910	COG2084	Dehydrogenase
PI93_RS01915	COG2207	Transcriptional regulator
PI93_RS01925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PI93_RS01930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PI93_RS01935	COG0156	8-amino-7-oxononanoate synthase activity
PI93_RS01945	COG1024	Enoyl-CoA hydratase
PI93_RS01950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PI93_RS01965	COG0300	oxidoreductase activity
PI93_RS01970	COG0183	Belongs to the thiolase family
PI93_RS01975	COG0288	reversible hydration of carbon dioxide
PI93_RS01980	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
PI93_RS01985	COG1960	acyl-CoA dehydrogenase activity
PI93_RS01995	COG0789	Transcriptional regulator
PI93_RS02005	COG0477	Major facilitator Superfamily
PI93_RS02020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PI93_RS02030	COG0018	arginyl-trna synthetase
PI93_RS02050	COG0646	methionine synthase
PI93_RS02050	COG1410	methionine synthase
PI93_RS02070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PI93_RS02095	COG1024	Enoyl-CoA hydratase
PI93_RS02135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PI93_RS02160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PI93_RS02165	COG1127	ABC transporter
PI93_RS02185	COG2814	Major facilitator Superfamily
PI93_RS02200	COG1686	Belongs to the peptidase S11 family
PI93_RS02205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PI93_RS02210	COG2921	Belongs to the UPF0250 family
PI93_RS02230	COG0321	lipoyl(octanoyl) transferase activity
PI93_RS02245	COG1414	Transcriptional regulator
PI93_RS02255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS02260	COG1116	anion transmembrane transporter activity
PI93_RS02265	COG1301	dicarboxylic acid transport
PI93_RS02270	COG4191	Histidine kinase
PI93_RS02275	COG2204	response regulator
PI93_RS02295	COG0606	chelatase, subunit chli
PI93_RS02300	COG2960	long-chain fatty acid transporting porin activity
PI93_RS02310	COG0347	Belongs to the P(II) protein family
PI93_RS02315	COG0004	ammonium transporteR
PI93_RS02330	COG0189	ligase activity
PI93_RS02340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PI93_RS02345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PI93_RS02350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PI93_RS02355	COG0793	Belongs to the peptidase S41A family
PI93_RS02365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PI93_RS02370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PI93_RS02375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
PI93_RS02385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PI93_RS02400	COG2226	methyltransferase
PI93_RS02405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PI93_RS02410	COG2423	ornithine cyclodeaminase activity
PI93_RS02425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PI93_RS02430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PI93_RS02440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS02445	COG2771	luxR family
PI93_RS02460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PI93_RS02465	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
PI93_RS02495	COG1612	heme a metabolic process
PI93_RS02505	COG1999	signal sequence binding
PI93_RS02515	COG1294	oxidase, subunit
PI93_RS02530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PI93_RS02540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PI93_RS02545	COG0625	glutathione transferase activity
PI93_RS02560	COG0612	Peptidase, M16
PI93_RS02565	COG0612	Peptidase, M16
PI93_RS02575	COG1131	(ABC) transporter
PI93_RS02580	COG0742	ribosomal rna small subunit methyltransferase
PI93_RS02585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PI93_RS02590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PI93_RS02595	COG0193	aminoacyl-tRNA hydrolase activity
PI93_RS02605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PI93_RS02620	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PI93_RS02635	COG1194	a g-specific adenine glycosylase
PI93_RS02640	COG1660	Displays ATPase and GTPase activities
PI93_RS02650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PI93_RS02660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PI93_RS02665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PI93_RS02670	COG1137	ATPase activity
PI93_RS02685	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PI93_RS02705	COG1280	lysine exporter protein (LysE YggA)
PI93_RS02715	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PI93_RS02720	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
PI93_RS02725	COG3639	organic phosphonate transmembrane transporter activity
PI93_RS02730	COG3454	Phosphonate metabolism
PI93_RS02735	COG4778	phosphonate C-P lyase system protein PhnL
PI93_RS02740	COG4107	phosphonate C-P lyase system protein PhnK
PI93_RS02745	COG3627	carbon phosphorus lyase activity
PI93_RS02750	COG3626	phosphonate metabolism
PI93_RS02755	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
PI93_RS02760	COG3624	Phosphonate C-P lyase system protein PhnG
PI93_RS02765	COG2188	Transcriptional regulator
PI93_RS02770	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
PI93_RS02795	COG0477	Major facilitator Superfamily
PI93_RS02810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PI93_RS02820	COG3842	ATPase activity
PI93_RS02825	COG1840	ABC-type Fe3 transport system, periplasmic component
PI93_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS02845	COG1283	sodium-dependent phosphate transmembrane transporter activity
PI93_RS02865	COG0251	oxidation-reduction process
PI93_RS02890	COG2814	Major facilitator Superfamily
PI93_RS02895	COG0629	single-stranded DNA binding
PI93_RS02920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS02925	COG0765	amino acid transport
PI93_RS02935	COG1418	mRNA catabolic process
PI93_RS02955	COG1473	amidohydrolase
PI93_RS02960	COG1802	Transcriptional regulator
PI93_RS02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS03005	COG0625	glutathione transferase activity
PI93_RS03035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS03040	COG0667	Aldo Keto reductase
PI93_RS03045	COG2207	Transcriptional regulator
PI93_RS03070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PI93_RS03075	COG2271	Major facilitator Superfamily
PI93_RS03080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS03085	COG0625	glutathione transferase activity
PI93_RS03105	COG0632	four-way junction helicase activity
PI93_RS03110	COG0583	DNA-binding transcription factor activity
PI93_RS03115	COG0477	Major facilitator Superfamily
PI93_RS03120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PI93_RS03130	COG4172	Belongs to the ABC transporter superfamily
PI93_RS03140	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS03150	COG0601	transmembrane transport
PI93_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS03165	COG3321	synthase
PI93_RS03165	COG0604	alcohol dehydrogenase
PI93_RS03195	COG0765	amino acid transport
PI93_RS03200	COG0010	Belongs to the arginase family
PI93_RS03205	COG1126	abc transporter atp-binding protein
PI93_RS03220	COG0110	maltose O-acetyltransferase activity
PI93_RS03250	COG4948	Mandelate Racemase Muconate Lactonizing
PI93_RS03255	COG0300	oxidoreductase activity
PI93_RS03260	COG2207	Transcriptional regulator
PI93_RS03295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS03300	COG0656	L-ascorbic acid biosynthetic process
PI93_RS03305	COG3038	cytochrome b561
PI93_RS03310	COG4771	TonB-dependent receptor
PI93_RS03320	COG3047	cAMP biosynthetic process
PI93_RS03330	COG0583	DNA-binding transcription factor activity
PI93_RS03350	COG0625	glutathione transferase activity
PI93_RS03360	COG1448	Aminotransferase
PI93_RS03380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PI93_RS03385	COG0183	Belongs to the thiolase family
PI93_RS03390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PI93_RS03400	COG1414	Transcriptional regulator
PI93_RS03435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS03465	COG0583	DNA-binding transcription factor activity
PI93_RS03485	COG2814	Major facilitator Superfamily
PI93_RS03500	COG0583	DNA-binding transcription factor activity
PI93_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
PI93_RS03520	COG0583	DNA-binding transcription factor activity
PI93_RS03525	COG1902	pentaerythritol trinitrate reductase activity
PI93_RS03530	COG1473	amidohydrolase
PI93_RS03570	COG1414	Transcriptional regulator
PI93_RS03575	COG1414	Transcriptional regulator
PI93_RS03590	COG0730	response to heat
PI93_RS03620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI93_RS03625	COG1228	amidohydrolase
PI93_RS03635	COG1113	amino acid transport
PI93_RS03640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS03645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PI93_RS03650	COG4521	taurine ABC transporter
PI93_RS03655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS03660	COG0625	glutathione transferase activity
PI93_RS03670	COG2207	Transcriptional regulator
PI93_RS03725	COG2271	Major facilitator Superfamily
PI93_RS03730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PI93_RS03740	COG0583	DNA-binding transcription factor activity
PI93_RS03745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PI93_RS03755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PI93_RS03760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS03780	COG0640	Transcriptional regulator
PI93_RS03820	COG3706	GGDEF domain
PI93_RS03820	COG4251	negative regulation of phosphorylation
PI93_RS03820	COG2203	Gaf domain
PI93_RS03820	COG5001	Diguanylate cyclase
PI93_RS03825	COG4999	Histidine kinase
PI93_RS03825	COG3850	Histidine kinase
PI93_RS03825	COG3437	response regulator, receiver
PI93_RS03825	COG2205	protein histidine kinase activity
PI93_RS03835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PI93_RS03845	COG0477	Major facilitator Superfamily
PI93_RS03865	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
PI93_RS03890	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PI93_RS03890	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PI93_RS03900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PI93_RS03910	COG1238	metal cluster binding
PI93_RS03930	COG0025	NhaP-type Na H and K H
PI93_RS03945	COG2226	methyltransferase
PI93_RS03960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PI93_RS03965	COG0500	methyltransferase
PI93_RS03985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PI93_RS03990	COG0494	nUDIX hydrolase
PI93_RS03995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PI93_RS04005	COG1960	acyl-CoA dehydrogenase activity
PI93_RS04010	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI93_RS04010	COG1024	Enoyl-CoA hydratase
PI93_RS04015	COG0183	Belongs to the thiolase family
PI93_RS04025	COG1607	acyl-coa hydrolase
PI93_RS04030	COG5265	(ABC) transporter
PI93_RS04040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PI93_RS04050	COG0765	amino acid transport
PI93_RS04055	COG0765	amino acid transport
PI93_RS04060	COG1126	abc transporter atp-binding protein
PI93_RS04065	COG0121	glutamine amidotransferase
PI93_RS04095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PI93_RS04100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PI93_RS04105	COG0316	Belongs to the HesB IscA family
PI93_RS04110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PI93_RS04115	COG0739	heme binding
PI93_RS04130	COG1881	PFAM PEBP family protein
PI93_RS04135	COG0406	alpha-ribazole phosphatase activity
PI93_RS04145	COG2255	four-way junction helicase activity
PI93_RS04150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PI93_RS04180	COG0800	Aldolase
PI93_RS04190	COG3265	gluconokinase activity
PI93_RS04210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PI93_RS04215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PI93_RS04220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PI93_RS04230	COG0482	sulfurtransferase activity
PI93_RS04235	COG0069	glutamate synthase activity
PI93_RS04240	COG2207	Transcriptional regulator
PI93_RS04305	COG2197	response regulator
PI93_RS04345	COG4794	Type iii secretion
PI93_RS04360	COG0741	lytic transglycosylase activity
PI93_RS04375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PI93_RS04380	COG3909	cytochrome
PI93_RS04395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PI93_RS04400	COG1862	Preprotein translocase
PI93_RS04405	COG0343	queuine tRNA-ribosyltransferase activity
PI93_RS04415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PI93_RS04425	COG0753	catalase activity
PI93_RS04430	COG0352	thiamine-phosphate diphosphorylase activity
PI93_RS04435	COG0783	Belongs to the Dps family
PI93_RS04445	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PI93_RS04465	COG1741	Belongs to the pirin family
PI93_RS04515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI93_RS04525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI93_RS04555	COG4128	Pfam Zonular occludens toxin
PI93_RS04610	COG2205	protein histidine kinase activity
PI93_RS04610	COG2770	Histidine kinase
PI93_RS04665	COG4771	TonB-dependent receptor
PI93_RS04680	COG4948	Mandelate Racemase Muconate Lactonizing
PI93_RS04710	COG0745	RESPONSE REGULATOR receiver
PI93_RS04725	COG3842	ATPase activity
PI93_RS04730	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS04735	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS04740	COG3938	Belongs to the proline racemase family
PI93_RS04760	COG0583	DNA-binding transcription factor activity
PI93_RS04775	COG0811	peptide transport
PI93_RS04880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PI93_RS04890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PI93_RS04900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PI93_RS04915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PI93_RS04920	COG4772	TonB-dependent receptor
PI93_RS04925	COG3971	2-oxopent-4-enoate hydratase activity
PI93_RS04935	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS04945	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS04950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PI93_RS04970	COG1448	Aminotransferase
PI93_RS04975	COG0583	DNA-binding transcription factor activity
PI93_RS04995	COG0412	Dienelactone hydrolase
PI93_RS05010	COG2207	Transcriptional regulator
PI93_RS05025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS05030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PI93_RS05035	COG0049	tRNA binding
PI93_RS05040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PI93_RS05045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PI93_RS05050	COG0051	transcription antitermination factor activity, RNA binding
PI93_RS05055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PI93_RS05060	COG0088	Forms part of the polypeptide exit tunnel
PI93_RS05065	COG0089	rRNA binding
PI93_RS05070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PI93_RS05075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PI93_RS05080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PI93_RS05085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PI93_RS05090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PI93_RS05095	COG0255	Belongs to the universal ribosomal protein uL29 family
PI93_RS05100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PI93_RS05105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PI93_RS05110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PI93_RS05115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PI93_RS05120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PI93_RS05130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PI93_RS05135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PI93_RS05140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PI93_RS05155	COG0201	protein transport
PI93_RS05160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PI93_RS05165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PI93_RS05175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PI93_RS05180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PI93_RS05185	COG0202	RNA polymerase activity
PI93_RS05190	COG0203	ribosomal protein L17
PI93_RS05200	COG4232	protein-disulfide reductase activity
PI93_RS05210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PI93_RS05220	COG1333	cytochrome c biogenesis protein
PI93_RS05225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PI93_RS05230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PI93_RS05235	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PI93_RS05240	COG0019	diaminopimelate decarboxylase activity
PI93_RS05245	COG1965	Belongs to the frataxin family
PI93_RS05280	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PI93_RS05290	COG3047	cAMP biosynthetic process
PI93_RS05295	COG3047	cAMP biosynthetic process
PI93_RS05305	COG0067	glutamate synthase
PI93_RS05305	COG0070	glutamate synthase
PI93_RS05305	COG0069	glutamate synthase activity
PI93_RS05315	COG2271	Major facilitator Superfamily
PI93_RS05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS05340	COG4178	(ABC) transporter
PI93_RS05360	COG0352	thiamine-phosphate diphosphorylase activity
PI93_RS05370	COG1127	ABC transporter
PI93_RS05375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PI93_RS05380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PI93_RS05400	COG1131	(ABC) transporter
PI93_RS05405	COG0842	Transport permease protein
PI93_RS05425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PI93_RS05440	COG0131	Imidazoleglycerol-phosphate dehydratase
PI93_RS05445	COG2095	MarC family integral membrane protein
PI93_RS05450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PI93_RS05465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PI93_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PI93_RS05495	COG0805	protein transport
PI93_RS05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI93_RS05505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PI93_RS05515	COG0723	plastoquinol--plastocyanin reductase activity
PI93_RS05520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PI93_RS05525	COG2857	Cytochrome c1
PI93_RS05530	COG0625	glutathione transferase activity
PI93_RS05535	COG2969	positive regulation of protein catabolic process
PI93_RS05680	COG1473	amidohydrolase
PI93_RS05690	COG1737	Transcriptional regulator
PI93_RS05695	COG2271	Major facilitator Superfamily
PI93_RS05710	COG1454	alcohol dehydrogenase
PI93_RS05715	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS05720	COG3284	Transcriptional regulator
PI93_RS05725	COG3045	CreA protein
PI93_RS05745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PI93_RS05755	COG1215	transferase activity, transferring glycosyl groups
PI93_RS05775	COG1696	Membrane protein involved in D-alanine export
PI93_RS05780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PI93_RS05805	COG1451	nucleotide metabolic process
PI93_RS05815	COG0477	Major facilitator Superfamily
PI93_RS05840	COG1254	Belongs to the acylphosphatase family
PI93_RS05845	COG1408	metallophosphoesterase
PI93_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS05875	COG0835	chemotaxis
PI93_RS05880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PI93_RS05885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PI93_RS05915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PI93_RS05920	COG2890	protein-(glutamine-N5) methyltransferase activity
PI93_RS05925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PI93_RS05930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PI93_RS05945	COG0477	Major facilitator Superfamily
PI93_RS05960	COG0463	Glycosyl transferase, family 2
PI93_RS05980	COG0012	GTP binding
PI93_RS05985	COG2321	neutral zinc metallopeptidase
PI93_RS05990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS05995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PI93_RS06005	COG0583	DNA-binding transcription factor activity
PI93_RS06030	COG4774	siderophore transport
PI93_RS06035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PI93_RS06045	COG0134	indole-3-glycerol-phosphate synthase activity
PI93_RS06050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PI93_RS06065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PI93_RS06070	COG4232	protein-disulfide reductase activity
PI93_RS06075	COG0745	RESPONSE REGULATOR receiver
PI93_RS06080	COG0642	Histidine kinase
PI93_RS06090	COG0842	Transport permease protein
PI93_RS06095	COG0842	Transport permease protein
PI93_RS06095	COG1129	ABC transporter
PI93_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS06115	COG0546	phosphoglycolate phosphatase activity
PI93_RS06120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PI93_RS06125	COG2967	ApaG domain
PI93_RS06130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PI93_RS06140	COG2050	protein possibly involved in aromatic compounds catabolism
PI93_RS06145	COG1024	Enoyl-CoA hydratase
PI93_RS06150	COG0183	Belongs to the thiolase family
PI93_RS06160	COG1024	Enoyl-CoA hydratase
PI93_RS06200	COG1473	amidohydrolase
PI93_RS06205	COG0243	molybdopterin cofactor binding
PI93_RS06220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS06235	COG0275	rRNA processing
PI93_RS06240	COG3116	cell division
PI93_RS06250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PI93_RS06255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PI93_RS06265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PI93_RS06275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PI93_RS06280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PI93_RS06285	COG1181	Belongs to the D-alanine--D-alanine ligase family
PI93_RS06290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PI93_RS06305	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PI93_RS06315	COG0653	protein targeting
PI93_RS06320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PI93_RS06335	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
PI93_RS06365	COG4536	flavin adenine dinucleotide binding
PI93_RS06375	COG0142	geranyltranstransferase activity
PI93_RS06385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PI93_RS06390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PI93_RS06405	COG0494	nUDIX hydrolase
PI93_RS06410	COG0442	prolyl-tRNA aminoacylation
PI93_RS06415	COG2095	MarC family integral membrane protein
PI93_RS06425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PI93_RS06430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PI93_RS06460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PI93_RS06480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PI93_RS06480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PI93_RS06500	COG0439	Biotin carboxylase
PI93_RS06505	COG0511	ligase activity, forming carbon-carbon bonds
PI93_RS06510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PI93_RS06515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PI93_RS06525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PI93_RS06530	COG3150	esterase
PI93_RS06535	COG0557	exoribonuclease II activity
PI93_RS06550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PI93_RS06555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PI93_RS06560	COG0668	transmembrane transport
PI93_RS06565	COG0598	Magnesium transport protein CorA
PI93_RS06570	COG0284	orotidine-5'-phosphate decarboxylase activity
PI93_RS06575	COG1058	Belongs to the CinA family
PI93_RS06575	COG1546	Belongs to the CinA family
PI93_RS06580	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PI93_RS06590	COG0280	phosphate acetyltransferase
PI93_RS06590	COG0281	malic enzyme
PI93_RS06610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PI93_RS06620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PI93_RS06625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PI93_RS06630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PI93_RS06640	COG0735	belongs to the Fur family
PI93_RS06645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PI93_RS06650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PI93_RS06655	COG0495	leucyl-tRNA aminoacylation
PI93_RS06670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PI93_RS06680	COG2207	Transcriptional regulator
PI93_RS06695	COG3608	succinylglutamate desuccinylase aspartoacylase
PI93_RS06695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PI93_RS06700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS06705	COG0138	bifunctional purine biosynthesis protein purh
PI93_RS06710	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PI93_RS06720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS06725	COG0006	proline dipeptidase activity
PI93_RS06735	COG3178	'Phosphotransferase
PI93_RS06745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PI93_RS06750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PI93_RS06765	COG1773	rubredoxin
PI93_RS06770	COG0346	lactoylglutathione lyase activity
PI93_RS06780	COG0204	Acyl-transferase
PI93_RS06785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PI93_RS06790	COG0751	glycine-tRNA ligase activity
PI93_RS06795	COG0752	glycyl-tRNA synthetase alpha subunit
PI93_RS06800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PI93_RS06810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
PI93_RS06820	COG1702	phosphate starvation-inducible protein PhoH
PI93_RS06825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PI93_RS06830	COG0803	Belongs to the bacterial solute-binding protein 9 family
PI93_RS06840	COG1121	(ABC) transporter
PI93_RS06845	COG2766	serine protein kinase
PI93_RS06850	COG2718	Belongs to the UPF0229 family
PI93_RS06855	COG2719	SpoVR family
PI93_RS06865	COG3706	GGDEF domain
PI93_RS06890	COG0668	transmembrane transport
PI93_RS06905	COG1902	pentaerythritol trinitrate reductase activity
PI93_RS06920	COG0840	transmembrane signaling receptor activity
PI93_RS06925	COG1396	sequence-specific DNA binding
PI93_RS06930	COG0156	8-amino-7-oxononanoate synthase activity
PI93_RS06935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS06950	COG1116	anion transmembrane transporter activity
PI93_RS06965	COG0628	permease
PI93_RS06970	COG0583	DNA-binding transcription factor activity
PI93_RS06975	COG1253	flavin adenine dinucleotide binding
PI93_RS07000	COG0477	Major facilitator Superfamily
PI93_RS07005	COG0642	Histidine kinase
PI93_RS07015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PI93_RS07020	COG2137	regulation of response to DNA damage stimulus
PI93_RS07030	COG0045	succinate-CoA ligase (ADP-forming) activity
PI93_RS07035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PI93_RS07040	COG0861	Integral membrane protein TerC family
PI93_RS07045	COG4969	Belongs to the N-Me-Phe pilin family
PI93_RS07060	COG1773	rubredoxin
PI93_RS07070	COG1678	Uncharacterized ACR, COG1678
PI93_RS07075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PI93_RS07080	COG0540	Belongs to the ATCase OTCase family
PI93_RS07095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PI93_RS07100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PI93_RS07105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PI93_RS07110	COG0438	transferase activity, transferring glycosyl groups
PI93_RS07115	COG0438	transferase activity, transferring glycosyl groups
PI93_RS07120	COG0438	transferase activity, transferring glycosyl groups
PI93_RS07160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PI93_RS07195	COG1733	regulation of RNA biosynthetic process
PI93_RS07200	COG2814	Major facilitator Superfamily
PI93_RS07225	COG2814	Major facilitator Superfamily
PI93_RS07245	COG0405	Gamma-glutamyltransferase
PI93_RS07260	COG1278	Cold shock
PI93_RS07265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PI93_RS07280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PI93_RS07300	COG0235	Class ii aldolase
PI93_RS07305	COG1309	transcriptional regulator
PI93_RS07320	COG2076	Multidrug Resistance protein
PI93_RS07325	COG0625	glutathione transferase activity
PI93_RS07340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PI93_RS07345	COG2249	NAD(P)H dehydrogenase (quinone) activity
PI93_RS07370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PI93_RS07375	COG2814	Major facilitator Superfamily
PI93_RS07405	COG3781	membrane
PI93_RS07430	COG2031	fatty acid transporter
PI93_RS07460	COG0531	amino acid
PI93_RS07470	COG0306	phosphate transporter
PI93_RS07500	COG2885	chlorophyll binding
PI93_RS07515	COG2855	membrane
PI93_RS07545	COG0583	DNA-binding transcription factor activity
PI93_RS07560	COG2205	protein histidine kinase activity
PI93_RS07560	COG0784	Response regulator, receiver
PI93_RS07560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS07560	COG2198	Histidine kinase
PI93_RS07570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PI93_RS07585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI93_RS07595	COG2807	transmembrane transport
PI93_RS07605	COG0534	Mate efflux family protein
PI93_RS07615	COG1280	lysine exporter protein (LysE YggA)
PI93_RS07620	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PI93_RS07630	COG4942	peptidase
PI93_RS07635	COG1278	Cold shock
PI93_RS07640	COG1280	lysine exporter protein (LysE YggA)
PI93_RS07645	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PI93_RS07655	COG1253	flavin adenine dinucleotide binding
PI93_RS07660	COG0583	DNA-binding transcription factor activity
PI93_RS07665	COG3384	dioxygenase
PI93_RS07675	COG0247	lactate metabolic process
PI93_RS07680	COG0277	FAD linked oxidase domain protein
PI93_RS07685	COG0277	FAD linked oxidase domain protein
PI93_RS07690	COG2186	Transcriptional regulator
PI93_RS07710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PI93_RS07715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PI93_RS07720	COG1556	Lactate utilization protein
PI93_RS07750	COG0303	'Molybdopterin
PI93_RS07755	COG0746	molybdenum cofactor guanylyltransferase activity
PI93_RS07765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PI93_RS07770	COG1530	ribonuclease E activity
PI93_RS07775	COG0564	pseudouridine synthase activity
PI93_RS07780	COG0546	phosphoglycolate phosphatase activity
PI93_RS07790	COG0616	signal peptide processing
PI93_RS07790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PI93_RS07795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PI93_RS07805	COG1399	metal-binding, possibly nucleic acid-binding protein
PI93_RS07810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PI93_RS07815	COG0416	fatty acid biosynthetic process
PI93_RS07820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PI93_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS07835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PI93_RS07840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PI93_RS07860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI93_RS07875	COG0681	Belongs to the peptidase S26 family
PI93_RS07880	COG0571	ribonuclease III activity
PI93_RS07885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PI93_RS07895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PI93_RS07900	COG0736	holo-[acyl-carrier-protein] synthase activity
PI93_RS07905	COG1472	Belongs to the glycosyl hydrolase 3 family
PI93_RS07920	COG0322	excinuclease ABC activity
PI93_RS07925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PI93_RS07930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PI93_RS07965	COG2188	Transcriptional regulator
PI93_RS07970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS07975	COG4948	Mandelate Racemase Muconate Lactonizing
PI93_RS07985	COG3842	ATPase activity
PI93_RS08015	COG0583	DNA-binding transcription factor activity
PI93_RS08020	COG1335	isochorismatase
PI93_RS08065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS08070	COG2721	sulfolactate sulfo-lyase activity
PI93_RS08080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PI93_RS08105	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
PI93_RS08110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PI93_RS08175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PI93_RS08205	COG0765	amino acid transport
PI93_RS08210	COG0765	amino acid transport
PI93_RS08225	COG4633	Protein conserved in bacteria
PI93_RS08240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PI93_RS08255	COG0386	Belongs to the glutathione peroxidase family
PI93_RS08265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS08270	COG0277	FAD linked oxidase domain protein
PI93_RS08275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PI93_RS08280	COG0277	FAD linked oxidase domain protein
PI93_RS08285	COG0277	FAD linked oxidase domain protein
PI93_RS08290	COG2096	Adenosyltransferase
PI93_RS08295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PI93_RS08300	COG0312	modulator of DNA gyrase
PI93_RS08305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PI93_RS08315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PI93_RS08320	COG0497	DNA recombination
PI93_RS08340	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PI93_RS08365	COG0443	Heat shock 70 kDa protein
PI93_RS08375	COG0512	Glutamine amidotransferase of anthranilate synthase
PI93_RS08375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PI93_RS08400	COG0641	radical SAM
PI93_RS08410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS08420	COG0745	RESPONSE REGULATOR receiver
PI93_RS08425	COG0642	Histidine kinase
PI93_RS08435	COG1428	Deoxynucleoside kinase
PI93_RS08440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PI93_RS08445	COG0617	tRNA 3'-terminal CCA addition
PI93_RS08455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PI93_RS08460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PI93_RS08470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PI93_RS08480	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS08490	COG3842	ATPase activity
PI93_RS08505	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PI93_RS08510	COG0586	Pfam SNARE associated Golgi protein
PI93_RS08515	COG0860	N-Acetylmuramoyl-L-alanine amidase
PI93_RS08520	COG0802	atpase or kinase
PI93_RS08525	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PI93_RS08530	COG4974	Belongs to the 'phage' integrase family
PI93_RS08535	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS08540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PI93_RS08545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PI93_RS08555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PI93_RS08565	COG3123	guanosine phosphorylase activity
PI93_RS08570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PI93_RS08580	COG0268	Binds directly to 16S ribosomal RNA
PI93_RS08585	COG0728	peptidoglycan biosynthetic process
PI93_RS08590	COG2912	Transglutaminase-like superfamily
PI93_RS08605	COG0563	adenylate kinase activity
PI93_RS08615	COG2835	tetraacyldisaccharide 4'-kinase activity
PI93_RS08620	COG1663	tetraacyldisaccharide 4'-kinase activity
PI93_RS08630	COG0811	peptide transport
PI93_RS08635	COG1570	exodeoxyribonuclease VII activity
PI93_RS08640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PI93_RS08685	COG0583	DNA-binding transcription factor activity
PI93_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS08725	COG1278	Cold shock
PI93_RS08730	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PI93_RS08735	COG0542	response to heat
PI93_RS08745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PI93_RS08750	COG2814	Major facilitator Superfamily
PI93_RS08755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PI93_RS08760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PI93_RS08765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PI93_RS08770	COG0196	riboflavin kinase activity
PI93_RS08775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PI93_RS08780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PI93_RS08780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI93_RS08785	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PI93_RS08785	COG3264	Mechanosensitive ion channel
PI93_RS08795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PI93_RS08805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PI93_RS08810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PI93_RS08820	COG2003	Belongs to the UPF0758 family
PI93_RS08825	COG1047	Peptidyl-prolyl cis-trans
PI93_RS08830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PI93_RS08850	COG0411	ABC transporter
PI93_RS08870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PI93_RS08875	COG0543	2 iron, 2 sulfur cluster binding
PI93_RS08875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI93_RS08895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS08910	COG0745	RESPONSE REGULATOR receiver
PI93_RS08930	COG0346	lactoylglutathione lyase activity
PI93_RS08950	COG0281	malic enzyme
PI93_RS08950	COG0280	phosphate acetyltransferase
PI93_RS08955	COG0765	amino acid transport
PI93_RS08960	COG0765	amino acid transport
PI93_RS08980	COG0583	DNA-binding transcription factor activity
PI93_RS08990	COG0640	Transcriptional regulator
PI93_RS09005	COG0477	Major facilitator Superfamily
PI93_RS09015	COG2916	Histone family protein nucleoid-structuring protein H-NS
PI93_RS09020	COG2205	protein histidine kinase activity
PI93_RS09025	COG0745	RESPONSE REGULATOR receiver
PI93_RS09030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS09035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS09040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS09045	COG1538	Outer membrane efflux protein
PI93_RS09050	COG2197	response regulator
PI93_RS09055	COG1289	transmembrane transporter activity
PI93_RS09060	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PI93_RS09065	COG1074	ATP-dependent DNA helicase activity
PI93_RS09070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PI93_RS09075	COG1253	flavin adenine dinucleotide binding
PI93_RS09085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PI93_RS09095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PI93_RS09120	COG0583	DNA-binding transcription factor activity
PI93_RS09130	COG0513	Belongs to the DEAD box helicase family
PI93_RS09135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI93_RS09180	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PI93_RS09190	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PI93_RS09195	COG1530	ribonuclease E activity
PI93_RS09200	COG0424	maF-like protein
PI93_RS09205	COG0584	glycerophosphoryl diester phosphodiesterase
PI93_RS09215	COG0395	ABC-type sugar transport system, permease component
PI93_RS09220	COG1175	transmembrane transport
PI93_RS09225	COG1653	transport
PI93_RS09235	COG0799	negative regulation of ribosome biogenesis
PI93_RS09250	COG0668	transmembrane transport
PI93_RS09255	COG0151	Belongs to the GarS family
PI93_RS09265	COG0433	COG0433 Predicted ATPase
PI93_RS09275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PI93_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS09285	COG1803	Methylglyoxal synthase
PI93_RS09300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PI93_RS09305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS09310	COG3284	Transcriptional regulator
PI93_RS09315	COG0583	DNA-binding transcription factor activity
PI93_RS09320	COG1802	Transcriptional regulator
PI93_RS09330	COG1454	alcohol dehydrogenase
PI93_RS09335	COG0477	Major facilitator Superfamily
PI93_RS09355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PI93_RS09360	COG0183	Belongs to the thiolase family
PI93_RS09380	COG0436	Aminotransferase
PI93_RS09390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PI93_RS09415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS09420	COG0402	S-adenosylhomocysteine deaminase activity
PI93_RS09430	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS09465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS09470	COG1538	Outer membrane efflux protein
PI93_RS09480	COG0583	DNA-binding transcription factor activity
PI93_RS09490	COG0583	DNA-binding transcription factor activity
PI93_RS09495	COG2197	response regulator
PI93_RS09530	COG1846	Transcriptional regulator
PI93_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS09540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PI93_RS09550	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS09555	COG1960	acyl-CoA dehydrogenase activity
PI93_RS09560	COG0477	Major facilitator Superfamily
PI93_RS09565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PI93_RS09575	COG0243	molybdopterin cofactor binding
PI93_RS09585	COG3707	response regulator
PI93_RS09590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS09590	COG1116	anion transmembrane transporter activity
PI93_RS09600	COG2824	Alkylphosphonate utilization operon protein PhnA
PI93_RS09635	COG1309	transcriptional regulator
PI93_RS09640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS09645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS09650	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PI93_RS09660	COG0673	inositol 2-dehydrogenase activity
PI93_RS09680	COG1988	membrane-bound metal-dependent
PI93_RS09685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PI93_RS09735	COG0747	negative chemotaxis
PI93_RS09745	COG0444	Belongs to the ABC transporter superfamily
PI93_RS09755	COG0601	transmembrane transport
PI93_RS09760	COG2072	flavoprotein involved in K transport
PI93_RS09770	COG2176	DNA-directed DNA polymerase activity
PI93_RS09785	COG3706	GGDEF domain
PI93_RS09795	COG1802	Transcriptional regulator
PI93_RS09810	COG0596	Alpha beta hydrolase
PI93_RS09840	COG2010	Cytochrome c
PI93_RS09855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI93_RS09865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI93_RS09870	COG0745	RESPONSE REGULATOR receiver
PI93_RS09875	COG2205	protein histidine kinase activity
PI93_RS09900	COG0459	protein refolding
PI93_RS09905	COG0583	DNA-binding transcription factor activity
PI93_RS09915	COG1846	Transcriptional regulator
PI93_RS09925	COG0315	cyclic pyranopterin monophosphate synthase activity
PI93_RS09930	COG4783	chaperone-mediated protein folding
PI93_RS09945	COG0429	hydrolase of the alpha beta-hydrolase fold
PI93_RS09975	COG0126	phosphoglycerate kinase activity
PI93_RS09980	COG0469	pyruvate kinase activity
PI93_RS10000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PI93_RS10005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PI93_RS10010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PI93_RS10015	COG0009	L-threonylcarbamoyladenylate synthase
PI93_RS10025	COG2027	D-alanyl-D-alanine carboxypeptidase
PI93_RS10030	COG0745	RESPONSE REGULATOR receiver
PI93_RS10035	COG0642	Histidine kinase
PI93_RS10045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PI93_RS10055	COG3608	succinylglutamate desuccinylase aspartoacylase
PI93_RS10055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PI93_RS10070	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
PI93_RS10075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PI93_RS10085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PI93_RS10090	COG4149	molybdate abc transporter
PI93_RS10095	COG0725	ABC transporter, periplasmic molybdate-binding protein
PI93_RS10100	COG1309	transcriptional regulator
PI93_RS10110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS10115	COG1538	Outer membrane efflux protein
PI93_RS10155	COG4575	ribosome binding
PI93_RS10160	COG0450	alkyl hydroperoxide reductase
PI93_RS10165	COG1960	acyl-CoA dehydrogenase activity
PI93_RS10175	COG3483	tryptophan 2,3-dioxygenase activity
PI93_RS10185	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PI93_RS10195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS10200	COG2309	aminopeptidase activity
PI93_RS10225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS10230	COG0765	amino acid transport
PI93_RS10235	COG1126	abc transporter atp-binding protein
PI93_RS10245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI93_RS10260	COG0477	Major facilitator Superfamily
PI93_RS10265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PI93_RS10275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PI93_RS10280	COG0259	pyridoxamine-phosphate oxidase activity
PI93_RS10285	COG2982	Protein involved in outer membrane biogenesis
PI93_RS10290	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PI93_RS10295	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS10325	COG1309	transcriptional regulator
PI93_RS10330	COG1113	amino acid transport
PI93_RS10335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS10340	COG1522	sequence-specific DNA binding
PI93_RS10345	COG1304	FMN binding
PI93_RS10355	COG0583	DNA-binding transcription factor activity
PI93_RS10370	COG0154	amidase activity
PI93_RS10395	COG1116	anion transmembrane transporter activity
PI93_RS10405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS10415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PI93_RS10420	COG1960	acyl-CoA dehydrogenase activity
PI93_RS10445	COG1454	alcohol dehydrogenase
PI93_RS10465	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS10475	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS10480	COG1414	Transcriptional regulator
PI93_RS10490	COG1802	Transcriptional regulator
PI93_RS10495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PI93_RS10500	COG2271	Major facilitator Superfamily
PI93_RS10505	COG0277	FAD linked oxidase domain protein
PI93_RS10505	COG0247	lactate metabolic process
PI93_RS10550	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS10590	COG0842	Transport permease protein
PI93_RS10595	COG1131	(ABC) transporter
PI93_RS10600	COG2764	glyoxalase bleomycin resistance protein dioxygenase
PI93_RS10615	COG0583	DNA-binding transcription factor activity
PI93_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS10630	COG1522	sequence-specific DNA binding
PI93_RS10645	COG1764	response to oxidative stress
PI93_RS10660	COG1742	UPF0060 membrane protein
PI93_RS10675	COG0583	DNA-binding transcription factor activity
PI93_RS10685	COG1522	sequence-specific DNA binding
PI93_RS10690	COG1280	lysine exporter protein (LysE YggA)
PI93_RS10695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PI93_RS10705	COG1845	cytochrome c oxidase, subunit III
PI93_RS10710	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PI93_RS10745	COG0583	DNA-binding transcription factor activity
PI93_RS10750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PI93_RS10755	COG1305	Transglutaminase-like
PI93_RS10785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PI93_RS10805	COG0693	protein deglycase activity
PI93_RS10810	COG1683	Conserved Protein
PI93_RS10820	COG0583	DNA-binding transcription factor activity
PI93_RS10825	COG1063	alcohol dehydrogenase
PI93_RS10835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PI93_RS10850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS10855	COG0583	DNA-binding transcription factor activity
PI93_RS10870	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS10900	COG0583	DNA-binding transcription factor activity
PI93_RS10925	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS10945	COG1917	Cupin 2, conserved barrel domain protein
PI93_RS10975	COG4208	sulfate ABC transporter
PI93_RS10985	COG3842	ATPase activity
PI93_RS10990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PI93_RS10995	COG1017	nitric oxide dioxygenase activity
PI93_RS10995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI93_RS11025	COG0540	Belongs to the ATCase OTCase family
PI93_RS11045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PI93_RS11050	COG2271	Major facilitator Superfamily
PI93_RS11055	COG0500	methyltransferase
PI93_RS11060	COG0308	aminopeptidase N
PI93_RS11070	COG2119	membrane
PI93_RS11085	COG0402	S-adenosylhomocysteine deaminase activity
PI93_RS11090	COG2252	PERMEase
PI93_RS11095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PI93_RS11105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PI93_RS11120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PI93_RS11145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PI93_RS11145	COG4651	solute:proton antiporter activity
PI93_RS11155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI93_RS11160	COG2608	mercury ion transmembrane transporter activity
PI93_RS11165	COG2217	Heavy metal translocating P-type atpase
PI93_RS11170	COG3568	Endonuclease Exonuclease Phosphatase
PI93_RS11175	COG0789	Transcriptional regulator
PI93_RS11215	COG1914	H( )-stimulated, divalent metal cation uptake system
PI93_RS11230	COG0587	DNA-directed DNA polymerase activity
PI93_RS11235	COG3549	Plasmid maintenance system killer
PI93_RS11245	COG2233	PERMEase
PI93_RS11270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS11285	COG0513	Belongs to the DEAD box helicase family
PI93_RS11290	COG2902	Dehydrogenase
PI93_RS11295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS11325	COG2252	PERMEase
PI93_RS11345	COG1283	sodium-dependent phosphate transmembrane transporter activity
PI93_RS11360	COG2271	Major facilitator Superfamily
PI93_RS11380	COG0328	RNA-DNA hybrid ribonuclease activity
PI93_RS11390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PI93_RS11395	COG0741	lytic transglycosylase activity
PI93_RS11395	COG1388	LysM domain
PI93_RS11405	COG2814	Major facilitator Superfamily
PI93_RS11410	COG0583	DNA-binding transcription factor activity
PI93_RS11435	COG3210	domain, Protein
PI93_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS11455	COG1024	Enoyl-CoA hydratase
PI93_RS11460	COG1960	acyl-CoA dehydrogenase activity
PI93_RS11485	COG4266	Belongs to the allantoicase family
PI93_RS11490	COG1301	dicarboxylic acid transport
PI93_RS11510	COG0505	Belongs to the CarA family
PI93_RS11520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PI93_RS11525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PI93_RS11535	COG1534	Rna-binding protein
PI93_RS11545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PI93_RS11550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PI93_RS11560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PI93_RS11565	COG0573	inorganic phosphate transmembrane transporter activity
PI93_RS11570	COG0581	inorganic phosphate transmembrane transporter activity
PI93_RS11575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PI93_RS11585	COG0745	RESPONSE REGULATOR receiver
PI93_RS11595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PI93_RS11610	COG2062	phosphohistidine phosphatase, SixA
PI93_RS11630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS11640	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS11645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
PI93_RS11650	COG1802	Transcriptional regulator
PI93_RS11660	COG0477	Major facilitator Superfamily
PI93_RS11665	COG1335	isochorismatase
PI93_RS11675	COG1802	Transcriptional regulator
PI93_RS11680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS11705	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS11730	COG1802	Transcriptional regulator
PI93_RS11735	COG1802	Transcriptional regulator
PI93_RS11755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PI93_RS11770	COG0583	DNA-binding transcription factor activity
PI93_RS11775	COG3384	dioxygenase
PI93_RS11780	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
PI93_RS11790	COG3384	dioxygenase
PI93_RS11815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PI93_RS11865	COG0477	Major facilitator Superfamily
PI93_RS11880	COG0583	DNA-binding transcription factor activity
PI93_RS11890	COG2188	Transcriptional regulator
PI93_RS11920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PI93_RS11925	COG0066	3-isopropylmalate dehydratase activity
PI93_RS11940	COG1335	isochorismatase
PI93_RS11955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS11965	COG0477	Major facilitator Superfamily
PI93_RS11970	COG0235	Class ii aldolase
PI93_RS11975	COG1942	4-Oxalocrotonate Tautomerase
PI93_RS11995	COG0425	Belongs to the sulfur carrier protein TusA family
PI93_RS12005	COG0525	valine-tRNA ligase activity
PI93_RS12010	COG0210	DNA helicase
PI93_RS12020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PI93_RS12030	COG2391	methyltransferase activity
PI93_RS12035	COG1611	Belongs to the LOG family
PI93_RS12045	COG1252	NADH dehydrogenase
PI93_RS12050	COG0412	Dienelactone hydrolase
PI93_RS12075	COG1722	exodeoxyribonuclease VII activity
PI93_RS12080	COG0142	geranyltranstransferase activity
PI93_RS12085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PI93_RS12095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PI93_RS12100	COG2081	HI0933 family
PI93_RS12105	COG1610	YqeY-like protein
PI93_RS12115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PI93_RS12125	COG2957	Belongs to the agmatine deiminase family
PI93_RS12130	COG0583	DNA-binding transcription factor activity
PI93_RS12140	COG0252	asparaginase activity
PI93_RS12150	COG0840	transmembrane signaling receptor activity
PI93_RS12160	COG0840	transmembrane signaling receptor activity
PI93_RS12165	COG0427	acetyl-CoA hydrolase
PI93_RS12170	COG0583	DNA-binding transcription factor activity
PI93_RS12180	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PI93_RS12195	COG2814	Major facilitator Superfamily
PI93_RS12200	COG2814	Major facilitator Superfamily
PI93_RS12220	COG0747	negative chemotaxis
PI93_RS12225	COG2084	Dehydrogenase
PI93_RS12230	COG0129	dihydroxy-acid dehydratase activity
PI93_RS12240	COG2271	Major facilitator Superfamily
PI93_RS12245	COG0583	DNA-binding transcription factor activity
PI93_RS12280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PI93_RS12300	COG1929	Belongs to the glycerate kinase type-1 family
PI93_RS12320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PI93_RS12335	COG0583	DNA-binding transcription factor activity
PI93_RS12345	COG0842	Transport permease protein
PI93_RS12350	COG1131	(ABC) transporter
PI93_RS12360	COG0302	gtp cyclohydrolase
PI93_RS12375	COG1294	oxidase, subunit
PI93_RS12380	COG1271	oxidase subunit
PI93_RS12390	COG2223	nitrite transmembrane transporter activity
PI93_RS12405	COG1902	pentaerythritol trinitrate reductase activity
PI93_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS12415	COG2271	Major facilitator Superfamily
PI93_RS12440	COG3038	cytochrome b561
PI93_RS12455	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PI93_RS12490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PI93_RS12500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PI93_RS12515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PI93_RS12530	COG0583	DNA-binding transcription factor activity
PI93_RS12540	COG3842	ATPase activity
PI93_RS12545	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS12590	COG1022	Amp-dependent synthetase and ligase
PI93_RS12595	COG0411	ABC transporter
PI93_RS12600	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS12645	COG1021	2,3-dihydroxybenzoate-AMP ligase
PI93_RS12660	COG1309	transcriptional regulator
PI93_RS12720	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
PI93_RS12735	COG0745	RESPONSE REGULATOR receiver
PI93_RS12740	COG2200	EAL domain
PI93_RS12745	COG2197	response regulator
PI93_RS12825	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS12840	COG0410	ABC transporter
PI93_RS12865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI93_RS12870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PI93_RS12875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PI93_RS12885	COG1561	YicC-like family, N-terminal region
PI93_RS12900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PI93_RS12910	COG1741	Belongs to the pirin family
PI93_RS12920	COG3118	belongs to the thioredoxin family
PI93_RS12950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PI93_RS12955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PI93_RS12960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
PI93_RS12965	COG2205	protein histidine kinase activity
PI93_RS12970	COG0745	RESPONSE REGULATOR receiver
PI93_RS12975	COG2076	Multidrug Resistance protein
PI93_RS12985	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
PI93_RS12990	COG2346	COG2346, Truncated hemoglobins
PI93_RS13005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PI93_RS13025	COG1309	transcriptional regulator
PI93_RS13035	COG0438	transferase activity, transferring glycosyl groups
PI93_RS13065	COG1595	DNA-templated transcription, initiation
PI93_RS13070	COG0028	Belongs to the TPP enzyme family
PI93_RS13080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PI93_RS13090	COG1183	phosphatidylcholine synthase activity
PI93_RS13095	COG1652	LysM domain
PI93_RS13115	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PI93_RS13150	COG0534	Mate efflux family protein
PI93_RS13160	COG0254	rRNA binding
PI93_RS13185	COG0277	FAD linked oxidase domain protein
PI93_RS13210	COG2267	carboxylic ester hydrolase activity
PI93_RS13225	COG0477	Major facilitator Superfamily
PI93_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS13250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PI93_RS13260	COG2197	response regulator
PI93_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS13285	COG0251	oxidation-reduction process
PI93_RS13290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PI93_RS13300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PI93_RS13305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PI93_RS13315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PI93_RS13330	COG0776	regulation of translation
PI93_RS13355	COG1773	rubredoxin
PI93_RS13380	COG2202	Pas domain
PI93_RS13380	COG2199	diguanylate cyclase activity
PI93_RS13380	COG2200	EAL domain
PI93_RS13385	COG2501	S4 domain
PI93_RS13395	COG3706	GGDEF domain
PI93_RS13400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS13420	COG3842	ATPase activity
PI93_RS13425	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS13430	COG1177	transmembrane transport
PI93_RS13445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS13465	COG5001	Diguanylate cyclase
PI93_RS13465	COG4251	negative regulation of phosphorylation
PI93_RS13465	COG3706	GGDEF domain
PI93_RS13465	COG2203	Gaf domain
PI93_RS13485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PI93_RS13535	COG3188	usher protein
PI93_RS13550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI93_RS13590	COG0840	transmembrane signaling receptor activity
PI93_RS13600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PI93_RS13605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PI93_RS13610	COG0567	Dehydrogenase, E1 component
PI93_RS13615	COG0508	dehydrogenase complex catalyzes the overall conversion of
PI93_RS13620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PI93_RS13625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PI93_RS13655	COG1846	Transcriptional regulator
PI93_RS13700	COG4964	Belongs to the GSP D family
PI93_RS13740	COG2204	response regulator
PI93_RS13750	COG3158	transport of potassium into the cell
PI93_RS13755	COG2183	response to ionizing radiation
PI93_RS13770	COG1199	ATP-dependent helicase activity
PI93_RS13775	COG0505	Belongs to the CarA family
PI93_RS13800	COG3243	poly(R)-hydroxyalkanoic acid synthase
PI93_RS13805	COG0183	Belongs to the thiolase family
PI93_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS13820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PI93_RS13825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PI93_RS13830	COG0183	Belongs to the thiolase family
PI93_RS13835	COG0626	cystathionine gamma-synthase activity
PI93_RS13840	COG0560	Phosphoserine phosphatase
PI93_RS13845	COG4977	sequence-specific DNA binding
PI93_RS13875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PI93_RS13880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PI93_RS13890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PI93_RS13895	COG0450	alkyl hydroperoxide reductase
PI93_RS13900	COG2205	protein histidine kinase activity
PI93_RS13905	COG0745	RESPONSE REGULATOR receiver
PI93_RS13980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
PI93_RS13995	COG1278	Cold shock
PI93_RS14020	COG0024	Methionine aminopeptidase
PI93_RS14040	COG1538	Outer membrane efflux protein
PI93_RS14060	COG0583	DNA-binding transcription factor activity
PI93_RS14075	COG0583	DNA-binding transcription factor activity
PI93_RS14085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PI93_RS14085	COG0189	ligase activity
PI93_RS14090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PI93_RS14090	COG0189	ligase activity
PI93_RS14095	COG1132	(ABC) transporter
PI93_RS14105	COG2974	May be involved in recombination
PI93_RS14120	COG0583	DNA-binding transcription factor activity
PI93_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS14145	COG0850	regulation of cytokinetic process
PI93_RS14155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PI93_RS14165	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS14170	COG0183	Belongs to the thiolase family
PI93_RS14195	COG0544	peptidyl-prolyl cis-trans isomerase activity
PI93_RS14200	COG0740	serine-type endopeptidase activity
PI93_RS14210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PI93_RS14215	COG0776	regulation of translation
PI93_RS14230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PI93_RS14240	COG4181	ATPase activity
PI93_RS14245	COG0166	Belongs to the GPI family
PI93_RS14250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PI93_RS14250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PI93_RS14255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS14260	COG0047	phosphoribosylformylglycinamidine synthase activity
PI93_RS14260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PI93_RS14265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PI93_RS14275	COG2917	probably involved in intracellular septation
PI93_RS14285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PI93_RS14290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PI93_RS14295	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS14300	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS14310	COG0411	ABC transporter
PI93_RS14325	COG1335	isochorismatase
PI93_RS14335	COG2130	NADP-dependent
PI93_RS14350	COG0354	folic acid binding
PI93_RS14355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PI93_RS14360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PI93_RS14370	COG0084	hydrolase, TatD family'
PI93_RS14385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PI93_RS14395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PI93_RS14400	COG1254	Belongs to the acylphosphatase family
PI93_RS14405	COG0840	transmembrane signaling receptor activity
PI93_RS14410	COG2205	protein histidine kinase activity
PI93_RS14410	COG0784	Response regulator, receiver
PI93_RS14415	COG1272	protein, Hemolysin III
PI93_RS14425	COG1522	sequence-specific DNA binding
PI93_RS14430	COG0028	Belongs to the TPP enzyme family
PI93_RS14455	COG3138	arginine N-succinyltransferase
PI93_RS14490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PI93_RS14490	COG1042	CoA-binding domain protein
PI93_RS14490	COG0045	succinate-CoA ligase (ADP-forming) activity
PI93_RS14495	COG0598	Magnesium transport protein CorA
PI93_RS14520	COG0784	Response regulator, receiver
PI93_RS14520	COG2205	protein histidine kinase activity
PI93_RS14550	COG2988	succinylglutamate desuccinylase activity
PI93_RS14555	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS14585	COG2226	methyltransferase
PI93_RS14615	COG1215	transferase activity, transferring glycosyl groups
PI93_RS14620	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PI93_RS14625	COG0457	Tetratricopeptide repeat
PI93_RS14630	COG0457	Tetratricopeptide repeat
PI93_RS14645	COG2194	sulfuric ester hydrolase activity
PI93_RS14650	COG0667	Aldo Keto reductase
PI93_RS14655	COG0589	response to stress
PI93_RS14660	COG1230	cation diffusion facilitator family transporter
PI93_RS14685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS14690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS14715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PI93_RS14715	COG2755	lipolytic protein G-D-S-L family
PI93_RS14720	COG0739	heme binding
PI93_RS14725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PI93_RS14745	COG4106	trans-aconitate 2-methyltransferase activity
PI93_RS14790	COG0840	transmembrane signaling receptor activity
PI93_RS14795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS14815	COG5002	protein histidine kinase activity
PI93_RS14815	COG5001	Diguanylate cyclase
PI93_RS14815	COG3447	MASE1 domain protein
PI93_RS14840	COG4774	siderophore transport
PI93_RS14845	COG3712	iron ion homeostasis
PI93_RS14850	COG1595	DNA-templated transcription, initiation
PI93_RS14855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PI93_RS14860	COG1024	Enoyl-CoA hydratase
PI93_RS14865	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI93_RS14870	COG3246	L-lysine catabolic process to acetate
PI93_RS14880	COG1022	Amp-dependent synthetase and ligase
PI93_RS14885	COG2814	Major facilitator Superfamily
PI93_RS14905	COG0583	DNA-binding transcription factor activity
PI93_RS14930	COG2197	response regulator
PI93_RS14935	COG0402	S-adenosylhomocysteine deaminase activity
PI93_RS14950	COG0583	DNA-binding transcription factor activity
PI93_RS14955	COG3257	ureidoglycine aminohydrolase activity
PI93_RS14975	COG2186	Transcriptional regulator
PI93_RS14995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PI93_RS15000	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS15005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS15010	COG0346	lactoylglutathione lyase activity
PI93_RS15015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS15030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS15040	COG1113	amino acid transport
PI93_RS15065	COG3791	Glutathione-dependent formaldehyde-activating
PI93_RS15075	COG0745	RESPONSE REGULATOR receiver
PI93_RS15085	COG1764	response to oxidative stress
PI93_RS15100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS15125	COG1113	amino acid transport
PI93_RS15130	COG2986	histidine ammonia-lyase
PI93_RS15140	COG2188	Transcriptional regulator
PI93_RS15145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS15150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PI93_RS15165	COG0583	DNA-binding transcription factor activity
PI93_RS15195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PI93_RS15200	COG0583	DNA-binding transcription factor activity
PI93_RS15210	COG0840	transmembrane signaling receptor activity
PI93_RS15230	COG2301	Belongs to the HpcH HpaI aldolase family
PI93_RS15240	COG3493	citrate carrier protein
PI93_RS15245	COG0583	DNA-binding transcription factor activity
PI93_RS15250	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PI93_RS15260	COG1045	serine acetyltransferase
PI93_RS15295	COG0583	DNA-binding transcription factor activity
PI93_RS15300	COG1741	Belongs to the pirin family
PI93_RS15320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS15335	COG0439	Biotin carboxylase
PI93_RS15345	COG1024	Enoyl-CoA hydratase
PI93_RS15355	COG0747	negative chemotaxis
PI93_RS15360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PI93_RS15365	COG1053	succinate dehydrogenase
PI93_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS15375	COG0747	negative chemotaxis
PI93_RS15380	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS15390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI93_RS15395	COG0444	Belongs to the ABC transporter superfamily
PI93_RS15400	COG4608	Belongs to the ABC transporter superfamily
PI93_RS15410	COG1960	acyl-CoA dehydrogenase activity
PI93_RS15415	COG0183	Belongs to the thiolase family
PI93_RS15440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PI93_RS15450	COG0745	RESPONSE REGULATOR receiver
PI93_RS15480	COG1595	DNA-templated transcription, initiation
PI93_RS15500	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS15505	COG2271	Major facilitator Superfamily
PI93_RS15510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS15520	COG0579	oxidoreductase
PI93_RS15525	COG1560	Kdo2-lipid A biosynthetic process
PI93_RS15540	COG2271	Major facilitator Superfamily
PI93_RS15545	COG4948	Mandelate Racemase Muconate Lactonizing
PI93_RS15580	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI93_RS15590	COG0529	Catalyzes the synthesis of activated sulfate
PI93_RS15595	COG0457	Tetratricopeptide repeat
PI93_RS15610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PI93_RS15620	COG1802	Transcriptional regulator
PI93_RS15625	COG0625	glutathione transferase activity
PI93_RS15630	COG1595	DNA-templated transcription, initiation
PI93_RS15645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PI93_RS15660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PI93_RS15670	COG0640	Transcriptional regulator
PI93_RS15680	COG0798	PFAM Bile acid sodium symporter
PI93_RS15710	COG1053	succinate dehydrogenase
PI93_RS15745	COG0372	Belongs to the citrate synthase family
PI93_RS15750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS15755	COG3706	GGDEF domain
PI93_RS15760	COG1902	pentaerythritol trinitrate reductase activity
PI93_RS15760	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI93_RS15795	COG0513	Belongs to the DEAD box helicase family
PI93_RS15810	COG0642	Histidine kinase
PI93_RS15815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PI93_RS15840	COG1538	Outer membrane efflux protein
PI93_RS15850	COG5002	protein histidine kinase activity
PI93_RS15885	COG3550	peptidyl-serine autophosphorylation
PI93_RS15895	COG0534	Mate efflux family protein
PI93_RS15900	COG2814	Major facilitator Superfamily
PI93_RS15905	COG4572	Cation transport regulator
PI93_RS15920	COG2823	Periplasmic or secreted lipoprotein
PI93_RS15930	COG2203	Gaf domain
PI93_RS15930	COG3706	GGDEF domain
PI93_RS15930	COG4251	negative regulation of phosphorylation
PI93_RS15930	COG5001	Diguanylate cyclase
PI93_RS15940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PI93_RS15940	COG3264	Mechanosensitive ion channel
PI93_RS15980	COG2070	2-Nitropropane dioxygenase
PI93_RS15985	COG2070	2-Nitropropane dioxygenase
PI93_RS15990	COG0604	alcohol dehydrogenase
PI93_RS16015	COG1674	ftsk spoiiie
PI93_RS16025	COG5001	Diguanylate cyclase
PI93_RS16025	COG5002	protein histidine kinase activity
PI93_RS16040	COG2814	Major facilitator Superfamily
PI93_RS16055	COG3706	GGDEF domain
PI93_RS16070	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS16075	COG3842	ATPase activity
PI93_RS16085	COG1024	Enoyl-CoA hydratase
PI93_RS16090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PI93_RS16095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PI93_RS16100	COG0471	metal ion transport
PI93_RS16115	COG0733	neurotransmitter:sodium symporter activity
PI93_RS16140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PI93_RS16145	COG3383	formate dehydrogenase (NAD+) activity
PI93_RS16165	COG0243	molybdopterin cofactor binding
PI93_RS16205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PI93_RS16230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PI93_RS16255	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI93_RS16265	COG3706	GGDEF domain
PI93_RS16290	COG0488	(ABC) transporter
PI93_RS16315	COG1129	ABC transporter
PI93_RS16320	COG0583	DNA-binding transcription factor activity
PI93_RS16330	COG2233	PERMEase
PI93_RS16365	COG2308	Evidence 4 Homologs of previously reported genes of
PI93_RS16375	COG4266	Belongs to the allantoicase family
PI93_RS16390	COG1619	proteins homologs of microcin C7 resistance protein MccF
PI93_RS16395	COG0590	tRNA wobble adenosine to inosine editing
PI93_RS16435	COG0410	ABC transporter
PI93_RS16450	COG0583	DNA-binding transcription factor activity
PI93_RS16460	COG0583	DNA-binding transcription factor activity
PI93_RS16465	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS16470	COG0251	oxidation-reduction process
PI93_RS16480	COG0583	DNA-binding transcription factor activity
PI93_RS16485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PI93_RS16485	COG0519	Catalyzes the synthesis of GMP from XMP
PI93_RS16505	COG2914	Belongs to the UPF0125 (RnfH) family
PI93_RS16510	COG2867	negative regulation of translational initiation
PI93_RS16520	COG0330	HflC and HflK could
PI93_RS16535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PI93_RS16540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PI93_RS16565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI93_RS16580	COG0750	zinc metalloprotease
PI93_RS16585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PI93_RS16595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PI93_RS16610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PI93_RS16615	COG0052	Belongs to the universal ribosomal protein uS2 family
PI93_RS16620	COG0024	Methionine aminopeptidase
PI93_RS16630	COG1187	pseudouridine synthase activity
PI93_RS16635	COG0242	peptide deformylase activity
PI93_RS16640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PI93_RS16665	COG2171	N-acyltransferase activity
PI93_RS16670	COG1393	Belongs to the ArsC family
PI93_RS16675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PI93_RS16680	COG2890	protein-(glutamine-N5) methyltransferase activity
PI93_RS16690	COG0488	(ABC) transporter
PI93_RS16700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PI93_RS16705	COG0477	Major facilitator Superfamily
PI93_RS16710	COG0351	phosphomethylpyrimidine kinase
PI93_RS16720	COG1573	uracil-dna glycosylase
PI93_RS16730	COG1214	PFAM Peptidase M22, glycoprotease
PI93_RS16735	COG0513	Belongs to the DEAD box helicase family
PI93_RS16745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PI93_RS16755	COG0583	DNA-binding transcription factor activity
PI93_RS16765	COG2224	Isocitrate lyase
PI93_RS16770	COG0697	spore germination
PI93_RS16800	COG3275	phosphorelay sensor kinase activity
PI93_RS16810	COG0542	response to heat
PI93_RS16820	COG0314	molybdopterin synthase activity
PI93_RS16825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PI93_RS16845	COG0436	Aminotransferase
PI93_RS16855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PI93_RS16860	COG2076	Multidrug Resistance protein
PI93_RS16865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PI93_RS16875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS16875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PI93_RS16880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PI93_RS16880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS16890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PI93_RS16895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PI93_RS16900	COG0791	NLP P60 protein
PI93_RS16910	COG0306	phosphate transporter
PI93_RS16920	COG0305	Participates in initiation and elongation during chromosome replication
PI93_RS16925	COG0359	binds to the 23S rRNA
PI93_RS16930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PI93_RS16945	COG0583	DNA-binding transcription factor activity
PI93_RS16950	COG3960	tartronate-semialdehyde synthase activity
PI93_RS16955	COG3622	Belongs to the hyi family
PI93_RS16960	COG2084	Dehydrogenase
PI93_RS16965	COG0252	asparaginase activity
PI93_RS16970	COG0583	DNA-binding transcription factor activity
PI93_RS16975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PI93_RS16980	COG4208	sulfate ABC transporter
PI93_RS16985	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PI93_RS16990	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
PI93_RS17030	COG1566	PFAM secretion protein HlyD family protein
PI93_RS17035	COG2814	Major facilitator Superfamily
PI93_RS17055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PI93_RS17060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PI93_RS17070	COG0195	Participates in both transcription termination and antitermination
PI93_RS17070	COG2251	uridine kinase activity
PI93_RS17075	COG0779	Required for maturation of 30S ribosomal subunits
PI93_RS17080	COG1187	pseudouridine synthase activity
PI93_RS17085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PI93_RS17090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PI93_RS17100	COG0583	DNA-binding transcription factor activity
PI93_RS17110	COG1546	Belongs to the CinA family
PI93_RS17110	COG1058	Belongs to the CinA family
PI93_RS17130	COG1643	Atp-dependent helicase
PI93_RS17135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PI93_RS17135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PI93_RS17140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PI93_RS17150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PI93_RS17160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PI93_RS17165	COG0557	exoribonuclease II activity
PI93_RS17175	COG0667	Aldo Keto reductase
PI93_RS17180	COG0583	DNA-binding transcription factor activity
PI93_RS17190	COG2207	Transcriptional regulator
PI93_RS17205	COG1116	anion transmembrane transporter activity
PI93_RS17210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS17215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS17220	COG1187	pseudouridine synthase activity
PI93_RS17225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PI93_RS17230	COG2818	Glycosylase
PI93_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS17250	COG2186	Transcriptional regulator
PI93_RS17255	COG0387	Pfam Sodium calcium exchanger
PI93_RS17270	COG0307	riboflavin synthase, alpha
PI93_RS17275	COG0708	Exodeoxyribonuclease III
PI93_RS17370	COG0840	transmembrane signaling receptor activity
PI93_RS17375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PI93_RS17380	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PI93_RS17385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PI93_RS17425	COG0679	Auxin Efflux Carrier
PI93_RS17430	COG3706	GGDEF domain
PI93_RS17445	COG1278	Cold shock
PI93_RS17450	COG0435	Glutathione S-transferase
PI93_RS17465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PI93_RS17525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PI93_RS17600	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PI93_RS17605	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PI93_RS17610	COG0167	dihydroorotate dehydrogenase activity
PI93_RS17625	COG1139	Iron-sulfur cluster binding protein
PI93_RS17640	COG1414	Transcriptional regulator
PI93_RS17655	COG0697	spore germination
PI93_RS17660	COG0123	including yeast histone deacetylase and acetoin utilization protein
PI93_RS17670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PI93_RS17680	COG0508	dehydrogenase complex catalyzes the overall conversion of
PI93_RS17685	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PI93_RS17695	COG4566	intracellular signal transduction
PI93_RS17700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PI93_RS17715	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PI93_RS17720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PI93_RS17725	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PI93_RS17730	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
PI93_RS17735	COG0330	HflC and HflK could
PI93_RS17740	COG0330	HflC and HflK could
PI93_RS17745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PI93_RS17750	COG1923	regulation of RNA biosynthetic process
PI93_RS17755	COG1160	GTP binding
PI93_RS17765	COG2976	Protein conserved in bacteria
PI93_RS17770	COG0124	histidyl-tRNA synthetase
PI93_RS17775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PI93_RS17790	COG0105	UTP biosynthetic process
PI93_RS17820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PI93_RS17825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PI93_RS17830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS17840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS17845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS17850	COG2197	response regulator
PI93_RS17895	COG2204	response regulator
PI93_RS17905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PI93_RS17925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PI93_RS17935	COG1840	ABC-type Fe3 transport system, periplasmic component
PI93_RS17940	COG1752	Esterase of the alpha-beta hydrolase superfamily
PI93_RS17945	COG0791	NLP P60 protein
PI93_RS17950	COG4172	Belongs to the ABC transporter superfamily
PI93_RS17955	COG4239	(ABC) transporter, permease
PI93_RS17960	COG4174	ABC transporter (Permease)
PI93_RS18040	COG0527	aspartate kinase activity
PI93_RS18045	COG0037	tRNA processing
PI93_RS18050	COG0825	malonyl-CoA metabolic process
PI93_RS18055	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PI93_RS18075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PI93_RS18080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PI93_RS18085	COG1045	serine acetyltransferase
PI93_RS18100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI93_RS18115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS18120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PI93_RS18125	COG0431	NADPH-dependent FMN reductase
PI93_RS18135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI93_RS18135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI93_RS18140	COG0242	peptide deformylase activity
PI93_RS18145	COG2194	sulfuric ester hydrolase activity
PI93_RS18160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PI93_RS18185	COG0285	dihydrofolate synthase activity
PI93_RS18190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PI93_RS18195	COG0159	tryptophan synthase activity
PI93_RS18205	COG0133	tryptophan synthase activity
PI93_RS18210	COG0135	phosphoribosylanthranilate isomerase activity
PI93_RS18215	COG0101	tRNA pseudouridine synthase activity
PI93_RS18225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PI93_RS18250	COG0372	Belongs to the citrate synthase family
PI93_RS18255	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PI93_RS18260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PI93_RS18265	COG1053	succinate dehydrogenase
PI93_RS18280	COG2188	Transcriptional regulator
PI93_RS18295	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PI93_RS18315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PI93_RS18325	COG2866	Carboxypeptidase
PI93_RS18330	COG3022	response to hydroperoxide
PI93_RS18340	COG0436	Aminotransferase
PI93_RS18345	COG0625	glutathione transferase activity
PI93_RS18355	COG1250	3-hydroxyacyl-CoA dehydrogenase
PI93_RS18360	COG1024	Enoyl-CoA hydratase
PI93_RS18375	COG1960	acyl-CoA dehydrogenase activity
PI93_RS18380	COG0625	glutathione transferase activity
PI93_RS18410	COG1007	ATP synthesis coupled electron transport
PI93_RS18435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI93_RS18440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PI93_RS18445	COG1034	ATP synthesis coupled electron transport
PI93_RS18455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PI93_RS18465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI93_RS18475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PI93_RS18490	COG0149	triose-phosphate isomerase activity
PI93_RS18505	COG5002	protein histidine kinase activity
PI93_RS18505	COG3447	MASE1 domain protein
PI93_RS18505	COG5001	Diguanylate cyclase
PI93_RS18525	COG2850	peptidyl-arginine hydroxylation
PI93_RS18540	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PI93_RS18545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS18550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PI93_RS18555	COG0180	Tryptophanyl-tRNA synthetase
PI93_RS18560	COG1994	Peptidase M50
PI93_RS18565	COG0009	L-threonylcarbamoyladenylate synthase
PI93_RS18570	COG0613	PHP domain protein
PI93_RS18580	COG2833	Protein of unknown function (DUF455)
PI93_RS18590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PI93_RS18600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PI93_RS18605	COG0148	phosphopyruvate hydratase activity
PI93_RS18610	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PI93_RS18615	COG0504	CTP synthase activity
PI93_RS18620	COG2267	carboxylic ester hydrolase activity
PI93_RS18630	COG0084	hydrolase, TatD family'
PI93_RS18650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PI93_RS18675	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PI93_RS18700	COG2975	iron-sulfur cluster assembly
PI93_RS18715	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PI93_RS18725	COG0316	Belongs to the HesB IscA family
PI93_RS18730	COG0822	iron-sulfur transferase activity
PI93_RS18735	COG1104	cysteine desulfurase activity
PI93_RS18750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PI93_RS18760	COG0556	nucleotide-excision repair
PI93_RS18775	COG1309	transcriptional regulator
PI93_RS18780	COG2878	Part of a membrane complex involved in electron transport
PI93_RS18785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PI93_RS18790	COG0778	Nitroreductase
PI93_RS18815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PI93_RS18825	COG3135	benzoate transporter
PI93_RS18835	COG4106	trans-aconitate 2-methyltransferase activity
PI93_RS18870	COG0697	spore germination
PI93_RS18875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS18885	COG2814	Major facilitator Superfamily
PI93_RS18890	COG0583	DNA-binding transcription factor activity
PI93_RS18905	COG0741	lytic transglycosylase activity
PI93_RS18925	COG2153	protein acetylation
PI93_RS18945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PI93_RS18955	COG0415	Belongs to the DNA photolyase family
PI93_RS18970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PI93_RS18985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS18990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PI93_RS19000	COG0583	DNA-binding transcription factor activity
PI93_RS19005	COG1178	ABC-type Fe3 transport system permease component
PI93_RS19010	COG3842	ATPase activity
PI93_RS19015	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PI93_RS19025	COG2203	Gaf domain
PI93_RS19025	COG3706	GGDEF domain
PI93_RS19025	COG5001	Diguanylate cyclase
PI93_RS19025	COG4251	negative regulation of phosphorylation
PI93_RS19045	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS19055	COG0312	modulator of DNA gyrase
PI93_RS19060	COG3028	Belongs to the UPF0307 family
PI93_RS19065	COG0521	Mo-molybdopterin cofactor biosynthetic process
PI93_RS19070	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PI93_RS19075	COG0501	Belongs to the peptidase M48B family
PI93_RS19080	COG1162	GTPase activity
PI93_RS19085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PI93_RS19090	COG0494	nUDIX hydrolase
PI93_RS19095	COG0335	large ribosomal subunit rRNA binding
PI93_RS19100	COG0336	Belongs to the RNA methyltransferase TrmD family
PI93_RS19105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PI93_RS19110	COG0228	four-way junction DNA binding
PI93_RS19140	COG1522	sequence-specific DNA binding
PI93_RS19145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS19150	COG0686	Belongs to the AlaDH PNT family
PI93_RS19155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PI93_RS19165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PI93_RS19195	COG0583	DNA-binding transcription factor activity
PI93_RS19200	COG2814	Major facilitator Superfamily
PI93_RS19245	COG2814	Major facilitator Superfamily
PI93_RS19250	COG0543	2 iron, 2 sulfur cluster binding
PI93_RS19255	COG0167	dihydroorotate dehydrogenase activity
PI93_RS19335	COG1414	Transcriptional regulator
PI93_RS19340	COG2084	Dehydrogenase
PI93_RS19345	COG0824	Thioesterase
PI93_RS19355	COG0848	biopolymer transport protein
PI93_RS19365	COG0823	Involved in the tonB-independent uptake of proteins
PI93_RS19490	COG4789	Type iii secretion
PI93_RS19500	COG1157	protein secretion by the type III secretion system
PI93_RS19515	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PI93_RS19570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PI93_RS19590	COG0784	Response regulator, receiver
PI93_RS19590	COG2205	protein histidine kinase activity
PI93_RS19645	COG2814	Major facilitator Superfamily
PI93_RS19665	COG0583	DNA-binding transcription factor activity
PI93_RS19670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PI93_RS19675	COG1522	sequence-specific DNA binding
PI93_RS19680	COG1349	DNA-binding transcription factor activity
PI93_RS19690	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS19695	COG2207	Transcriptional regulator
PI93_RS19710	COG1959	2 iron, 2 sulfur cluster binding
PI93_RS19720	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS19725	COG0410	ABC transporter
PI93_RS19730	COG1137	ATPase activity
PI93_RS19750	COG2368	4-hydroxyphenylacetate
PI93_RS19755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PI93_RS19760	COG1104	cysteine desulfurase activity
PI93_RS19785	COG1595	DNA-templated transcription, initiation
PI93_RS19820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PI93_RS19830	COG1301	dicarboxylic acid transport
PI93_RS19835	COG1802	Transcriptional regulator
PI93_RS19850	COG1280	lysine exporter protein (LysE YggA)
PI93_RS19855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PI93_RS19860	COG1113	amino acid transport
PI93_RS19865	COG4821	SIS domain
PI93_RS19880	COG3276	selenocysteine insertion sequence binding
PI93_RS19895	COG2864	formate dehydrogenase
PI93_RS19900	COG0437	4 iron, 4 sulfur cluster binding
PI93_RS19915	COG2995	paraquat-inducible protein a
PI93_RS19920	COG3008	intermembrane lipid transfer
PI93_RS19935	COG2197	response regulator
PI93_RS19945	COG0477	Major facilitator Superfamily
PI93_RS19955	COG3387	PFAM Glycoside hydrolase 15-related
PI93_RS19960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS19965	COG1024	Enoyl-CoA hydratase
PI93_RS19975	COG1802	Transcriptional regulator
PI93_RS19990	COG0583	DNA-binding transcription factor activity
PI93_RS19995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PI93_RS20000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PI93_RS20005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PI93_RS20010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PI93_RS20025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PI93_RS20030	COG4191	Histidine kinase
PI93_RS20050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PI93_RS20060	COG1802	Transcriptional regulator
PI93_RS20065	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PI93_RS20075	COG3383	formate dehydrogenase (NAD+) activity
PI93_RS20110	COG2985	domain, Protein
PI93_RS20115	COG2985	domain, Protein
PI93_RS20125	COG0534	Mate efflux family protein
PI93_RS20145	COG0589	response to stress
PI93_RS20155	COG1175	transmembrane transport
PI93_RS20160	COG1653	transport
PI93_RS20190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PI93_RS20200	COG0747	negative chemotaxis
PI93_RS20205	COG4172	Belongs to the ABC transporter superfamily
PI93_RS20225	COG0762	integral membrane protein
PI93_RS20230	COG1024	Enoyl-CoA hydratase
PI93_RS20235	COG1960	acyl-CoA dehydrogenase activity
PI93_RS20240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PI93_RS20265	COG1414	Transcriptional regulator
PI93_RS20275	COG0579	oxidoreductase
PI93_RS20300	COG0277	FAD linked oxidase domain protein
PI93_RS20305	COG2186	Transcriptional regulator
PI93_RS20320	COG0004	ammonium transporteR
PI93_RS20325	COG2814	Major facilitator Superfamily
PI93_RS20345	COG1414	Transcriptional regulator
PI93_RS20350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PI93_RS20355	COG4569	acetaldehyde dehydrogenase (acetylating) activity
PI93_RS20380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS20385	COG1695	Transcriptional regulator
PI93_RS20390	COG2375	cellular response to nickel ion
PI93_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS20420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PI93_RS20430	COG0028	Belongs to the TPP enzyme family
PI93_RS20430	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
PI93_RS20440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PI93_RS20455	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PI93_RS20465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS20470	COG0463	Glycosyl transferase, family 2
PI93_RS20480	COG1657	PFAM Prenyltransferase squalene oxidase
PI93_RS20485	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PI93_RS20490	COG1562	ergosterol biosynthetic process
PI93_RS20495	COG1562	ergosterol biosynthetic process
PI93_RS20505	COG2070	2-Nitropropane dioxygenase
PI93_RS20510	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS20515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PI93_RS20540	COG0028	Belongs to the TPP enzyme family
PI93_RS20545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS20550	COG3842	ATPase activity
PI93_RS20560	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS20575	COG1414	Transcriptional regulator
PI93_RS20595	COG1845	cytochrome c oxidase, subunit III
PI93_RS20600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PI93_RS20605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PI93_RS20620	COG0745	RESPONSE REGULATOR receiver
PI93_RS20625	COG5002	protein histidine kinase activity
PI93_RS20630	COG1538	Outer membrane efflux protein
PI93_RS20640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PI93_RS20645	COG2860	membrane
PI93_RS20665	COG1595	DNA-templated transcription, initiation
PI93_RS20680	COG2271	Major facilitator Superfamily
PI93_RS20690	COG0235	Class ii aldolase
PI93_RS20695	COG2031	fatty acid transporter
PI93_RS20700	COG2423	ornithine cyclodeaminase activity
PI93_RS20705	COG0243	molybdopterin cofactor binding
PI93_RS20730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS20740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS20750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PI93_RS20760	COG1802	Transcriptional regulator
PI93_RS20770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS20775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS20820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS20825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PI93_RS20830	COG1595	DNA-templated transcription, initiation
PI93_RS20840	COG0583	DNA-binding transcription factor activity
PI93_RS20845	COG1764	response to oxidative stress
PI93_RS20880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS20890	COG0625	glutathione transferase activity
PI93_RS20910	COG2186	Transcriptional regulator
PI93_RS20930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS20935	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS20945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PI93_RS20955	COG4120	Belongs to the binding-protein-dependent transport system permease family
PI93_RS20960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PI93_RS20975	COG0028	Belongs to the TPP enzyme family
PI93_RS21070	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS21075	COG3193	protein, possibly involved in utilization of glycolate and propanediol
PI93_RS21095	COG0583	DNA-binding transcription factor activity
PI93_RS21110	COG3246	L-lysine catabolic process to acetate
PI93_RS21125	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS21165	COG1024	Enoyl-CoA hydratase
PI93_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21180	COG0183	Belongs to the thiolase family
PI93_RS21185	COG0302	gtp cyclohydrolase
PI93_RS21195	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21215	COG0300	oxidoreductase activity
PI93_RS21240	COG1960	acyl-CoA dehydrogenase activity
PI93_RS21245	COG1960	acyl-CoA dehydrogenase activity
PI93_RS21250	COG1960	acyl-CoA dehydrogenase activity
PI93_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21280	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS21305	COG0179	Fumarylacetoacetate (FAA) hydrolase
PI93_RS21315	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21325	COG0633	Ferredoxin
PI93_RS21330	COG1309	transcriptional regulator
PI93_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21360	COG1960	acyl-CoA dehydrogenase activity
PI93_RS21380	COG2186	Transcriptional regulator
PI93_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
PI93_RS21425	COG2814	Major facilitator Superfamily
PI93_RS21435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PI93_RS21445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS21450	COG1126	abc transporter atp-binding protein
PI93_RS21455	COG0765	amino acid transport
PI93_RS21460	COG0765	amino acid transport
PI93_RS21470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS21475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PI93_RS21480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PI93_RS21485	COG2080	2 iron, 2 sulfur cluster binding
PI93_RS21505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PI93_RS21520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PI93_RS21525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PI93_RS21530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PI93_RS21535	COG1674	ftsk spoiiie
PI93_RS21540	COG0492	ferredoxin-NADP+ reductase activity
PI93_RS21545	COG1193	negative regulation of DNA recombination
PI93_RS21550	COG2860	membrane
PI93_RS21570	COG2249	NAD(P)H dehydrogenase (quinone) activity
PI93_RS21580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PI93_RS21595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS21600	COG1176	ABC-type spermidine putrescine transport system, permease component I
PI93_RS21615	COG0277	FAD linked oxidase domain protein
PI93_RS21630	COG2271	Major facilitator Superfamily
PI93_RS21635	COG0477	Major facilitator Superfamily
PI93_RS21660	COG0181	hydroxymethylbilane synthase activity
PI93_RS21675	COG0165	Argininosuccinate lyase
PI93_RS21680	COG0786	glutamate:sodium symporter activity
PI93_RS21685	COG1982	Orn Lys Arg decarboxylase major
PI93_RS21690	COG0717	Belongs to the dCTP deaminase family
PI93_RS21695	COG0489	protein tyrosine kinase activity
PI93_RS21700	COG2885	chlorophyll binding
PI93_RS21705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI93_RS21705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PI93_RS21710	COG2226	methyltransferase
PI93_RS21715	COG1522	sequence-specific DNA binding
PI93_RS21730	COG2911	Protein conserved in bacteria
PI93_RS21750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PI93_RS21755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PI93_RS21760	COG0489	protein tyrosine kinase activity
PI93_RS21765	COG1492	cobalamin metabolic process
PI93_RS21775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PI93_RS21795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PI93_RS21800	COG0406	alpha-ribazole phosphatase activity
PI93_RS21805	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PI93_RS21810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PI93_RS21820	COG1120	ATPase activity
PI93_RS21825	COG4139	cobalamin transport
PI93_RS21830	COG4206	TonB-dependent receptor
PI93_RS21850	COG1960	acyl-CoA dehydrogenase activity
PI93_RS21880	COG0123	including yeast histone deacetylase and acetoin utilization protein
PI93_RS21885	COG2951	lytic endotransglycosylase activity
PI93_RS21905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PI93_RS21915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PI93_RS21925	COG0776	regulation of translation
PI93_RS21935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PI93_RS21940	COG1914	H( )-stimulated, divalent metal cation uptake system
PI93_RS21950	COG0287	Prephenate dehydrogenase
PI93_RS21960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PI93_RS21995	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS22000	COG1024	Enoyl-CoA hydratase
PI93_RS22020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PI93_RS22025	COG1802	Transcriptional regulator
PI93_RS22030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PI93_RS22035	COG0583	DNA-binding transcription factor activity
PI93_RS22040	COG0129	dihydroxy-acid dehydratase activity
PI93_RS22055	COG1566	PFAM secretion protein HlyD family protein
PI93_RS22060	COG1289	transmembrane transporter activity
PI93_RS22085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PI93_RS22090	COG0795	lipopolysaccharide-transporting ATPase activity
PI93_RS22095	COG0795	lipopolysaccharide-transporting ATPase activity
PI93_RS22105	COG1648	precorrin-2 dehydrogenase activity
PI93_RS22105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PI93_RS22110	COG2895	sulfate adenylyltransferase (ATP) activity
PI93_RS22120	COG0175	sulfate reduction
PI93_RS22125	COG0730	response to heat
PI93_RS22130	COG0583	DNA-binding transcription factor activity
PI93_RS22145	COG2084	Dehydrogenase
PI93_RS22175	COG2072	flavoprotein involved in K transport
PI93_RS22185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS22210	COG0386	Belongs to the glutathione peroxidase family
PI93_RS22245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS22260	COG0028	Belongs to the TPP enzyme family
PI93_RS22270	COG1414	Transcriptional regulator
PI93_RS22290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS22305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS22325	COG0640	Transcriptional regulator
PI93_RS22335	COG2814	Major facilitator Superfamily
PI93_RS22340	COG0443	Heat shock 70 kDa protein
PI93_RS22350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PI93_RS22355	COG3360	Dodecin
PI93_RS22360	COG1846	Transcriptional regulator
PI93_RS22365	COG1737	Transcriptional regulator
PI93_RS22365	COG0837	glucose binding
PI93_RS22375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PI93_RS22390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PI93_RS22410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PI93_RS22420	COG0671	phosphoesterase, PA-phosphatase related
PI93_RS22425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PI93_RS22430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PI93_RS22435	COG1704	LemA family
PI93_RS22450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PI93_RS22450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PI93_RS22480	COG0559	Belongs to the binding-protein-dependent transport system permease family
PI93_RS22495	COG0410	ABC transporter
PI93_RS22505	COG0640	Transcriptional regulator
PI93_RS22515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PI93_RS22520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PI93_RS22535	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PI93_RS22545	COG0531	amino acid
PI93_RS22550	COG3300	MHYT domain
PI93_RS22550	COG5001	Diguanylate cyclase
PI93_RS22560	COG2011	ABC-type metal ion transport system permease component
PI93_RS22565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PI93_RS22570	COG2201	protein-glutamate methylesterase activity
PI93_RS22595	COG4585	Histidine kinase
PI93_RS22600	COG3237	CsbD-like
PI93_RS22655	COG0745	RESPONSE REGULATOR receiver
PI93_RS22660	COG2205	protein histidine kinase activity
PI93_RS22665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS22680	COG4149	molybdate abc transporter
PI93_RS22705	COG1987	bacterial-type flagellum assembly
PI93_RS22755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PI93_RS22760	COG4786	Flagellar basal body rod
PI93_RS22765	COG4786	Flagellar basal body rod
PI93_RS22780	COG1558	bacterial-type flagellum-dependent cell motility
PI93_RS22805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PI93_RS22810	COG1191	sigma factor activity
PI93_RS22860	COG3634	alkyl hydroperoxide reductase activity
PI93_RS22865	COG0450	alkyl hydroperoxide reductase
PI93_RS22880	COG1288	antiporter activity
PI93_RS22895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS22920	COG2814	Major facilitator Superfamily
PI93_RS22930	COG1917	Cupin 2, conserved barrel domain protein
PI93_RS22930	COG2207	Transcriptional regulator
PI93_RS22935	COG0596	Alpha beta hydrolase
PI93_RS22940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PI93_RS22950	COG3485	protocatechuate 3,4-dioxygenase
PI93_RS22955	COG3485	protocatechuate 3,4-dioxygenase
PI93_RS22960	COG0583	DNA-binding transcription factor activity
PI93_RS22970	COG1960	acyl-CoA dehydrogenase activity
PI93_RS22980	COG1012	belongs to the aldehyde dehydrogenase family
PI93_RS22985	COG1024	Enoyl-CoA hydratase
PI93_RS22990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PI93_RS22995	COG2814	Major facilitator Superfamily
PI93_RS23005	COG0745	RESPONSE REGULATOR receiver
PI93_RS23020	COG0840	transmembrane signaling receptor activity
PI93_RS23025	COG2198	Histidine kinase
PI93_RS23025	COG0643	Histidine kinase
PI93_RS23030	COG0583	DNA-binding transcription factor activity
PI93_RS23040	COG2814	Major facilitator Superfamily
PI93_RS23055	COG0601	transmembrane transport
PI93_RS23060	COG0747	negative chemotaxis
PI93_RS23065	COG4608	Belongs to the ABC transporter superfamily
PI93_RS23070	COG0444	Belongs to the ABC transporter superfamily
PI93_RS23080	COG0477	Major facilitator Superfamily
PI93_RS23085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PI93_RS23090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PI93_RS23095	COG1845	cytochrome c oxidase, subunit III
PI93_RS23110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PI93_RS23125	COG2011	ABC-type metal ion transport system permease component
PI93_RS23130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PI93_RS23135	COG1464	Belongs to the NlpA lipoprotein family
PI93_RS23140	COG1686	Belongs to the peptidase S11 family
PI93_RS23145	COG0477	Major facilitator Superfamily
PI93_RS23150	COG1297	OPT oligopeptide transporter protein
PI93_RS23180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PI93_RS23185	COG4774	siderophore transport
PI93_RS23190	COG3712	iron ion homeostasis
PI93_RS23210	COG3396	Phenylacetate-CoA oxygenase
PI93_RS23215	COG3460	Phenylacetate-CoA oxygenase
PI93_RS23220	COG3396	Phenylacetate-CoA oxygenase
PI93_RS23225	COG2151	metal-sulfur cluster biosynthetic enzyme
PI93_RS23230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI93_RS23250	COG1522	sequence-specific DNA binding
PI93_RS23270	COG2814	Major facilitator Superfamily
PI93_RS23275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PI93_RS23280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PI93_RS23290	COG2226	methyltransferase
PI93_RS23295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PI93_RS23320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PI93_RS23330	COG0513	Belongs to the DEAD box helicase family
PI93_RS23335	COG0583	DNA-binding transcription factor activity
PI93_RS23340	COG2233	PERMEase
PI93_RS23355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PI93_RS23360	COG2827	Endonuclease containing a URI domain
PI93_RS23380	COG0840	transmembrane signaling receptor activity
PI93_RS23430	COG4336	lyase activity
PI93_RS23435	COG0583	DNA-binding transcription factor activity
PI93_RS23450	COG1845	cytochrome c oxidase, subunit III
PI93_RS23460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PI93_RS23495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PI93_RS23505	COG0543	2 iron, 2 sulfur cluster binding
PI93_RS23505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PI93_RS23510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PI93_RS23565	COG0110	maltose O-acetyltransferase activity
PI93_RS23570	COG0438	transferase activity, transferring glycosyl groups
PI93_RS23600	COG0737	Belongs to the 5'-nucleotidase family
PI93_RS23610	COG2010	Cytochrome c
PI93_RS23630	COG4654	Cytochrome c, class I
PI93_RS23635	COG4654	Cytochrome c, class I
PI93_RS23640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PI93_RS23655	COG0446	pyridine nucleotide-disulphide oxidoreductase
PI93_RS23665	COG2823	Periplasmic or secreted lipoprotein
PI93_RS23670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PI93_RS23675	COG0792	nuclease activity
PI93_RS23705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PI93_RS23730	COG3622	Belongs to the hyi family
PI93_RS23735	COG1832	CoA-binding protein
PI93_RS23755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PI93_RS23770	COG0506	proline dehydrogenase activity
PI93_RS23770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PI93_RS23770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
PI93_RS23790	COG1115	amino acid carrier protein
PI93_RS23805	COG1760	l-serine dehydratase
PI93_RS23810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PI93_RS23810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PI93_RS23815	COG0509	glycine decarboxylation via glycine cleavage system
PI93_RS23820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PI93_RS23830	COG0210	DNA helicase
PI93_RS23840	COG3245	cytochrome
PI93_RS23870	COG2814	Major facilitator Superfamily
PI93_RS23875	COG3384	dioxygenase
PI93_RS23880	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI93_RS23885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI93_RS23885	COG0473	3-isopropylmalate dehydrogenase activity
PI93_RS23890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PI93_RS23900	COG0523	cobalamin synthesis protein
PI93_RS23905	COG4638	Rieske (2fe-2S)
PI93_RS23910	COG3384	dioxygenase
PI93_RS23920	COG2159	amidohydrolase
PI93_RS23945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PI93_RS23950	COG2205	protein histidine kinase activity
PI93_RS23955	COG0745	RESPONSE REGULATOR receiver
PI93_RS23970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PI93_RS23980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PI93_RS23985	COG0745	RESPONSE REGULATOR receiver
PI93_RS23995	COG3851	Histidine kinase
PI93_RS24000	COG2197	response regulator
PI93_RS24010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PI93_RS24030	COG2257	FlhB HrpN YscU SpaS Family
PI93_RS24050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PI93_RS24055	COG1317	bacterial-type flagellum organization
PI93_RS24065	COG2882	bacterial-type flagellum organization
PI93_RS24075	COG1580	Controls the rotational direction of flagella during chemotaxis
PI93_RS24115	COG1256	bacterial-type flagellum assembly
PI93_RS24125	COG1706	bacterial-type flagellum-dependent cell motility
PI93_RS24130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PI93_RS24135	COG4786	Flagellar basal body rod
PI93_RS24140	COG4787	bacterial-type flagellum-dependent cell motility
PI93_RS24145	COG1749	Flagellar hook protein flgE
PI93_RS24150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PI93_RS24155	COG1558	bacterial-type flagellum-dependent cell motility
PI93_RS24160	COG1815	bacterial-type flagellum-dependent cell motility
PI93_RS24190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PI93_RS24195	COG1191	sigma factor activity
PI93_RS24210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PI93_RS24220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PI93_RS24225	COG0745	RESPONSE REGULATOR receiver
PI93_RS24235	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PI93_RS24240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PI93_RS24245	COG0840	transmembrane signaling receptor activity
PI93_RS24250	COG0840	transmembrane signaling receptor activity
PI93_RS24255	COG0840	transmembrane signaling receptor activity
PI93_RS24260	COG0835	chemotaxis
PI93_RS24265	COG2198	Histidine kinase
PI93_RS24265	COG0643	Histidine kinase
PI93_RS24270	COG0784	Response regulator, receiver
PI93_RS24270	COG2205	protein histidine kinase activity
PI93_RS24270	COG2198	Histidine kinase
PI93_RS24275	COG1360	Flagellar Motor Protein
PI93_RS24295	COG2814	Major facilitator Superfamily
PI93_RS24300	COG0318	PFAM AMP-dependent synthetase and ligase
PI93_RS24305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PI93_RS24310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PI93_RS24315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PI93_RS24330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PI93_RS24340	COG0356	it plays a direct role in the translocation of protons across the membrane
PI93_RS24350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PI93_RS24355	COG1475	DNA binding
PI93_RS24360	COG1192	Involved in chromosome partitioning
PI93_RS24365	COG3040	lipid binding
PI93_RS24370	COG0357	Ribosomal RNA small subunit methyltransferase G
PI93_RS24375	COG0445	tRNA wobble uridine modification
PI93_RS24385	COG0411	ABC transporter
PI93_RS24395	COG1846	Transcriptional regulator
PI93_RS24430	COG0411	ABC transporter
PI93_RS24440	COG2226	methyltransferase
PI93_RS24455	COG0583	DNA-binding transcription factor activity
PI93_RS24500	COG1522	sequence-specific DNA binding
PI93_RS24505	COG4771	TonB-dependent receptor
PI93_RS24510	COG3720	iron ion transport
PI93_RS24515	COG4558	Periplasmic binding protein
PI93_RS24520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PI93_RS24530	COG2423	ornithine cyclodeaminase activity
PI93_RS24535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PI93_RS24555	COG1522	sequence-specific DNA binding
PI93_RS24560	COG3186	Phenylalanine-4-hydroxylase
PI93_RS24565	COG2154	pterin-4-alpha-carbinolamine dehydratase
PI93_RS24590	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PI93_RS24590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PI93_RS24595	COG0038	chloride channel
PI93_RS24600	COG1846	Transcriptional regulator
PI93_RS24610	COG2814	Major facilitator Superfamily
PI93_RS24645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PI93_RS24660	COG0594	ribonuclease P activity
PI93_RS24665	COG0230	Belongs to the bacterial ribosomal protein bL34 family