locus-tag	class	description
AL522_RS00140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AL522_RS00195	COG1295	ribonuclease BN
AL522_RS00670	COG0583	DNA-binding transcription factor activity
AL522_RS00760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL522_RS00795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL522_RS00820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL522_RS01190	COG2233	PERMEase
AL522_RS01200	COG2982	Protein involved in outer membrane biogenesis
AL522_RS01420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL522_RS01460	COG2814	Major facilitator Superfamily
AL522_RS01640	COG0187	DNA topoisomerase II activity
AL522_RS01715	COG2252	PERMEase
AL522_RS01775	COG0243	molybdopterin cofactor binding
AL522_RS01775	COG3383	formate dehydrogenase (NAD+) activity
AL522_RS01895	COG1215	transferase activity, transferring glycosyl groups
AL522_RS01910	COG1215	transferase activity, transferring glycosyl groups
AL522_RS01965	COG1215	transferase activity, transferring glycosyl groups
AL522_RS02000	COG2200	EAL domain
AL522_RS02000	COG2199	diguanylate cyclase activity
AL522_RS02060	COG0248	Ppx GppA phosphatase
AL522_RS02485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL522_RS02640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS02760	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AL522_RS02860	COG0583	DNA-binding transcription factor activity
AL522_RS02930	COG0137	argininosuccinate synthase activity
AL522_RS03005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL522_RS03030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL522_RS03150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL522_RS03210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL522_RS03265	COG2860	membrane
AL522_RS03530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL522_RS03535	COG2271	Major facilitator Superfamily
AL522_RS03545	COG1132	(ABC) transporter
AL522_RS03555	COG0583	DNA-binding transcription factor activity
AL522_RS03575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL522_RS03585	COG2271	Major facilitator Superfamily
AL522_RS03610	COG1971	Probably functions as a manganese efflux pump
AL522_RS03620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL522_RS03625	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL522_RS03635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AL522_RS03645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL522_RS03650	COG0625	glutathione transferase activity
AL522_RS03660	COG0300	oxidoreductase activity
AL522_RS03665	COG0583	DNA-binding transcription factor activity
AL522_RS03670	COG1295	ribonuclease BN
AL522_RS03675	COG0477	Major facilitator Superfamily
AL522_RS03685	COG0583	DNA-binding transcription factor activity
AL522_RS03695	COG0129	dihydroxy-acid dehydratase activity
AL522_RS03705	COG3978	acetolactate synthase activity
AL522_RS03715	COG0606	chelatase, subunit chli
AL522_RS03720	COG3085	chromosome segregation
AL522_RS03725	COG0583	DNA-binding transcription factor activity
AL522_RS03770	COG4206	TonB-dependent receptor
AL522_RS03785	COG1309	transcriptional regulator
AL522_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL522_RS03795	COG0583	DNA-binding transcription factor activity
AL522_RS03800	COG0678	peroxiredoxin activity
AL522_RS03800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL522_RS03810	COG0137	argininosuccinate synthase activity
AL522_RS03825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL522_RS03830	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL522_RS03835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL522_RS03840	COG0527	aspartate kinase activity
AL522_RS03840	COG0460	homoserine dehydrogenase
AL522_RS03845	COG0626	cystathionine gamma-synthase activity
AL522_RS03850	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL522_RS03855	COG0254	rRNA binding
AL522_RS03860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL522_RS03865	COG1609	Transcriptional regulator
AL522_RS03870	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL522_RS03875	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL522_RS03885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL522_RS03890	COG3074	FtsZ-dependent cytokinesis
AL522_RS03895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL522_RS03905	COG1494	fructose-1,6-bisphosphatase
AL522_RS03910	COG2814	Major facilitator Superfamily
AL522_RS03920	COG3152	Membrane
AL522_RS03930	COG0149	triose-phosphate isomerase activity
AL522_RS03935	COG2134	cdp-diacylglycerol pyrophosphatase
AL522_RS03940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AL522_RS03945	COG0205	6-phosphofructokinase activity
AL522_RS03955	COG3729	General stress protein
AL522_RS03960	COG3678	ATP-independent chaperone mediated protein folding
AL522_RS03965	COG0745	RESPONSE REGULATOR receiver
AL522_RS03970	COG2205	protein histidine kinase activity
AL522_RS03975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL522_RS03985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL522_RS03995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL522_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL522_RS04005	COG4942	peptidase
AL522_RS04010	COG2861	carbohydrate metabolic process
AL522_RS04015	COG0438	transferase activity, transferring glycosyl groups
AL522_RS04025	COG1063	alcohol dehydrogenase
AL522_RS04030	COG0156	8-amino-7-oxononanoate synthase activity
AL522_RS04035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL522_RS04040	COG0859	PFAM glycosyl transferase family 9
AL522_RS04045	COG0859	PFAM glycosyl transferase family 9
AL522_RS04060	COG1216	Glycosyl transferase, family 2
AL522_RS04065	COG0859	PFAM glycosyl transferase family 9
AL522_RS04075	COG1519	Transferase
AL522_RS04100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL522_RS04105	COG2003	Belongs to the UPF0758 family
AL522_RS04110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL522_RS04130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL522_RS04135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL522_RS04145	COG1561	YicC-like family, N-terminal region
AL522_RS04160	COG1560	Kdo2-lipid A biosynthetic process
AL522_RS04180	COG2244	polysaccharide biosynthetic process
AL522_RS04185	COG2860	membrane
AL522_RS04200	COG1758	RNA polymerase activity
AL522_RS04205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL522_RS04210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL522_RS04215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL522_RS04220	COG2233	PERMEase
AL522_RS04225	COG2982	Protein involved in outer membrane biogenesis
AL522_RS04230	COG0456	acetyltransferase
AL522_RS04245	COG1011	Hydrolase
AL522_RS04260	COG3852	Histidine kinase
AL522_RS04270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL522_RS04275	COG3078	GTPase activator activity
AL522_RS04285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL522_RS04285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL522_RS04295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL522_RS04300	COG3084	Protein conserved in bacteria
AL522_RS04305	COG0746	molybdenum cofactor guanylyltransferase activity
AL522_RS04310	COG1763	Mo-molybdopterin cofactor biosynthetic process
AL522_RS04335	COG0477	Major facilitator Superfamily
AL522_RS04340	COG1609	Transcriptional regulator
AL522_RS04345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL522_RS04350	COG1879	ABC-type sugar transport system periplasmic component
AL522_RS04360	COG1129	ABC transporter
AL522_RS04370	COG3111	PFAM Bacterial OB fold (BOF) protein
AL522_RS04375	COG0745	RESPONSE REGULATOR receiver
AL522_RS04380	COG0642	Histidine kinase
AL522_RS04395	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL522_RS04400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AL522_RS04405	COG1522	sequence-specific DNA binding
AL522_RS04410	COG0716	FMN binding
AL522_RS04420	COG0357	Ribosomal RNA small subunit methyltransferase G
AL522_RS04425	COG3312	ion transport
AL522_RS04430	COG0356	it plays a direct role in the translocation of protons across the membrane
AL522_RS04440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL522_RS04445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL522_RS04450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL522_RS04455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL522_RS04460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL522_RS04470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL522_RS04480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL522_RS04485	COG0573	inorganic phosphate transmembrane transporter activity
AL522_RS04490	COG0581	inorganic phosphate transmembrane transporter activity
AL522_RS04495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL522_RS04500	COG0704	Plays a role in the regulation of phosphate uptake
AL522_RS04505	COG2814	Major facilitator Superfamily
AL522_RS04510	COG1070	Carbohydrate kinase
AL522_RS04515	COG2115	Belongs to the xylose isomerase family
AL522_RS04525	COG4213	ABC transporter substrate-binding protein
AL522_RS04535	COG4214	carbohydrate transport
AL522_RS04540	COG2207	Transcriptional regulator
AL522_RS04540	COG1609	Transcriptional regulator
AL522_RS04545	COG2814	Major facilitator Superfamily
AL522_RS04555	COG1484	DNA-dependent DNA replication
AL522_RS04570	COG5571	outer membrane autotransporter
AL522_RS04575	COG2818	Glycosylase
AL522_RS04580	COG2885	chlorophyll binding
AL522_RS04590	COG1609	Transcriptional regulator
AL522_RS04600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL522_RS04615	COG3977	Valine--pyruvate aminotransferase
AL522_RS04620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL522_RS04630	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL522_RS04645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL522_RS04650	COG0697	spore germination
AL522_RS04660	COG5645	(Lipo)protein
AL522_RS04665	COG0823	Involved in the tonB-independent uptake of proteins
AL522_RS04670	COG0561	phosphatase activity
AL522_RS04675	COG2731	YhcH YjgK YiaL family protein
AL522_RS04680	COG0187	DNA topoisomerase II activity
AL522_RS04685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL522_RS04690	COG0592	DNA-directed DNA polymerase activity
AL522_RS04695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL522_RS04700	COG0594	ribonuclease P activity
AL522_RS04705	COG0706	membrane insertase activity
AL522_RS04725	COG2252	PERMEase
AL522_RS04730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL522_RS04740	COG3274	enterobacterial common antigen metabolic process
AL522_RS04745	COG0752	glycyl-tRNA synthetase alpha subunit
AL522_RS04750	COG0751	glycine-tRNA ligase activity
AL522_RS04765	COG0625	glutathione transferase activity
AL522_RS04775	COG2864	formate dehydrogenase
AL522_RS04780	COG0437	4 iron, 4 sulfur cluster binding
AL522_RS04785	COG0243	molybdopterin cofactor binding
AL522_RS04785	COG3383	formate dehydrogenase (NAD+) activity
AL522_RS04795	COG1349	DNA-binding transcription factor activity
AL522_RS04800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL522_RS04805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL522_RS04810	COG2990	Protein conserved in bacteria
AL522_RS04820	COG3722	fumarate hydratase activity
AL522_RS04830	COG2213	PTS system mannitol-specific
AL522_RS04830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS04845	COG2944	sequence-specific DNA binding
AL522_RS04855	COG1846	Transcriptional regulator
AL522_RS04860	COG1764	response to oxidative stress
AL522_RS04865	COG2194	sulfuric ester hydrolase activity
AL522_RS04875	COG0747	negative chemotaxis
AL522_RS04880	COG0601	transmembrane transport
AL522_RS04885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL522_RS04890	COG0444	Belongs to the ABC transporter superfamily
AL522_RS04895	COG4608	Belongs to the ABC transporter superfamily
AL522_RS04910	COG0455	bacterial-type flagellum organization
AL522_RS04915	COG1215	transferase activity, transferring glycosyl groups
AL522_RS04920	COG1215	transferase activity, transferring glycosyl groups
AL522_RS04925	COG0457	Tetratricopeptide repeat
AL522_RS04935	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AL522_RS04940	COG2194	sulfuric ester hydrolase activity
AL522_RS04970	COG1215	transferase activity, transferring glycosyl groups
AL522_RS04975	COG3118	belongs to the thioredoxin family
AL522_RS04975	COG0457	Tetratricopeptide repeat
AL522_RS04980	COG2200	EAL domain
AL522_RS04980	COG2199	diguanylate cyclase activity
AL522_RS04990	COG0612	Peptidase, M16
AL522_RS05005	COG2200	EAL domain
AL522_RS05010	COG2982	Protein involved in outer membrane biogenesis
AL522_RS05015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL522_RS05025	COG0248	Ppx GppA phosphatase
AL522_RS05035	COG3118	belongs to the thioredoxin family
AL522_RS05040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL522_RS05045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL522_RS05050	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
AL522_RS05055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL522_RS05060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL522_RS05065	COG1088	dTDP-glucose 4,6-dehydratase activity
AL522_RS05070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL522_RS05075	COG0456	acetyltransferase
AL522_RS05080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL522_RS05085	COG2244	polysaccharide biosynthetic process
AL522_RS05090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL522_RS05100	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL522_RS05125	COG3071	HemY protein
AL522_RS05130	COG2959	enzyme of heme biosynthesis
AL522_RS05135	COG1587	Uroporphyrinogen-III synthase
AL522_RS05140	COG0181	hydroxymethylbilane synthase activity
AL522_RS05155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL522_RS05170	COG1011	Hydrolase
AL522_RS05175	COG0210	DNA helicase
AL522_RS05185	COG3180	Ammonia monooxygenase
AL522_RS05190	COG2962	Rard protein
AL522_RS05195	COG2050	protein possibly involved in aromatic compounds catabolism
AL522_RS05210	COG1280	lysine exporter protein (LysE YggA)
AL522_RS05220	COG1280	lysine exporter protein (LysE YggA)
AL522_RS05225	COG2267	carboxylic ester hydrolase activity
AL522_RS05230	COG0561	phosphatase activity
AL522_RS05235	COG2271	Major facilitator Superfamily
AL522_RS05245	COG4807	Protein conserved in bacteria
AL522_RS05250	COG0583	DNA-binding transcription factor activity
AL522_RS05255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL522_RS05260	COG0412	Dienelactone hydrolase
AL522_RS05275	COG1322	Protein conserved in bacteria
AL522_RS05280	COG2226	methyltransferase
AL522_RS05290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL522_RS05295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL522_RS05305	COG0805	protein transport
AL522_RS05310	COG0084	hydrolase, TatD family'
AL522_RS05325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL522_RS05345	COG0006	proline dipeptidase activity
AL522_RS05350	COG1739	Uncharacterized protein family UPF0029
AL522_RS05385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL522_RS05390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL522_RS05390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL522_RS05430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL522_RS05435	COG0250	Participates in transcription elongation, termination and antitermination
AL522_RS05440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL522_RS05450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL522_RS05455	COG0222	ribosome binding
AL522_RS05460	COG0085	RNA polymerase activity
AL522_RS05465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL522_RS05475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL522_RS05485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL522_RS05490	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL522_RS05500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL522_RS05530	COG0138	bifunctional purine biosynthesis protein purh
AL522_RS05560	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL522_RS05565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL522_RS05585	COG1410	methionine synthase
AL522_RS05585	COG0646	methionine synthase
AL522_RS05590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS05620	COG0527	aspartate kinase activity
AL522_RS05635	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL522_RS05640	COG3842	ATPase activity
AL522_RS05675	COG3161	chorismate lyase activity
AL522_RS05690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL522_RS05700	COG0534	Mate efflux family protein
AL522_RS05710	COG0735	belongs to the Fur family
AL522_RS05720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL522_RS05740	COG1522	sequence-specific DNA binding
AL522_RS05750	COG1448	Aminotransferase
AL522_RS05760	COG2315	Protein conserved in bacteria
AL522_RS05765	COG1064	alcohol dehydrogenase
AL522_RS05770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL522_RS05775	COG0629	single-stranded DNA binding
AL522_RS05790	COG0697	spore germination
AL522_RS05820	COG0789	Transcriptional regulator
AL522_RS05830	COG2252	PERMEase
AL522_RS05835	COG0025	NhaP-type Na H and K H
AL522_RS05840	COG0583	DNA-binding transcription factor activity
AL522_RS05850	COG1346	cytolysis
AL522_RS05860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL522_RS05865	COG3162	membrane
AL522_RS05875	COG1301	dicarboxylic acid transport
AL522_RS05885	COG1263	PTS System
AL522_RS05885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL522_RS05890	COG0840	transmembrane signaling receptor activity
AL522_RS05930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AL522_RS05950	COG2271	Major facilitator Superfamily
AL522_RS05955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL522_RS05960	COG1473	amidohydrolase
AL522_RS05965	COG1473	amidohydrolase
AL522_RS05970	COG0583	DNA-binding transcription factor activity
AL522_RS05980	COG3248	Nucleoside-binding outer membrane protein
AL522_RS05985	COG0642	Histidine kinase
AL522_RS05995	COG4977	sequence-specific DNA binding
AL522_RS06010	COG4993	Dehydrogenase
AL522_RS06030	COG2971	BadF BadG BcrA BcrD
AL522_RS06035	COG1940	carbohydrate kinase activity
AL522_RS06055	COG1175	transmembrane transport
AL522_RS06060	COG0395	ABC-type sugar transport system, permease component
AL522_RS06070	COG0473	3-isopropylmalate dehydrogenase activity
AL522_RS06090	COG0625	glutathione transferase activity
AL522_RS06095	COG1082	Xylose isomerase domain protein TIM barrel
AL522_RS06125	COG3539	Fimbrial protein
AL522_RS06135	COG3121	Chaperone
AL522_RS06150	COG1309	transcriptional regulator
AL522_RS06160	COG1324	tolerance protein
AL522_RS06165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL522_RS06175	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL522_RS06180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL522_RS06195	COG1509	lysine 2,3-aminomutase activity
AL522_RS06200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL522_RS06210	COG3040	lipid binding
AL522_RS06215	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL522_RS06220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL522_RS06225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL522_RS06230	COG3105	Protein conserved in bacteria
AL522_RS06235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL522_RS06240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL522_RS06245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL522_RS06250	COG0625	glutathione transferase activity
AL522_RS06255	COG2969	positive regulation of protein catabolic process
AL522_RS06260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL522_RS06265	COG0070	glutamate synthase
AL522_RS06265	COG0069	glutamate synthase activity
AL522_RS06265	COG0067	glutamate synthase
AL522_RS06270	COG2198	Histidine kinase
AL522_RS06270	COG0784	Response regulator, receiver
AL522_RS06270	COG5002	protein histidine kinase activity
AL522_RS06280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS06295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL522_RS06300	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AL522_RS06305	COG1137	ATPase activity
AL522_RS06310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL522_RS06315	COG3117	lipopolysaccharide transmembrane transporter activity
AL522_RS06320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL522_RS06330	COG0530	calcium, potassium:sodium antiporter activity
AL522_RS06335	COG1127	ABC transporter
AL522_RS06340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL522_RS06345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL522_RS06350	COG2854	intermembrane phospholipid transfer
AL522_RS06355	COG3113	response to antibiotic
AL522_RS06360	COG5007	Belongs to the BolA IbaG family
AL522_RS06370	COG3423	Transcriptional regulator
AL522_RS06375	COG0142	geranyltranstransferase activity
AL522_RS06380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL522_RS06385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL522_RS06390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL522_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS06405	COG1535	isochorismatase
AL522_RS06405	COG3433	isochorismatase activity
AL522_RS06410	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL522_RS06415	COG1169	isochorismate synthase
AL522_RS06420	COG4592	Periplasmic binding protein
AL522_RS06430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL522_RS06435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL522_RS06440	COG1120	ATPase activity
AL522_RS06445	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AL522_RS06445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL522_RS06455	COG2382	esterase
AL522_RS06460	COG4771	TonB-dependent receptor
AL522_RS06465	COG2027	D-alanyl-D-alanine carboxypeptidase
AL522_RS06475	COG1534	Rna-binding protein
AL522_RS06480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL522_RS06490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL522_RS06495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL522_RS06500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL522_RS06515	COG0779	Required for maturation of 30S ribosomal subunits
AL522_RS06520	COG0195	Participates in both transcription termination and antitermination
AL522_RS06530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL522_RS06535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL522_RS06540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL522_RS06545	COG1185	polyribonucleotide nucleotidyltransferase activity
AL522_RS06555	COG0513	Belongs to the DEAD box helicase family
AL522_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS06565	COG2207	Transcriptional regulator
AL522_RS06570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL522_RS06575	COG0826	peptidase U32
AL522_RS06580	COG0826	peptidase U32
AL522_RS06585	COG3154	lipid carrier protein
AL522_RS06590	COG3153	acetyltransferase
AL522_RS06595	COG2827	Endonuclease containing a URI domain
AL522_RS06600	COG3787	Belongs to the UPF0306 family
AL522_RS06605	COG0693	protein deglycase activity
AL522_RS06610	COG0702	epimerase
AL522_RS06615	COG0602	queuosine metabolic process
AL522_RS06620	COG1328	CTP reductase activity
AL522_RS06630	COG1609	Transcriptional regulator
AL522_RS06640	COG0768	penicillin binding
AL522_RS06645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL522_RS06650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL522_RS06665	COG0318	PFAM AMP-dependent synthetase and ligase
AL522_RS06665	COG0204	Acyl-transferase
AL522_RS06680	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL522_RS06685	COG0540	Belongs to the ATCase OTCase family
AL522_RS06690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL522_RS06695	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AL522_RS06720	COG0525	valine-tRNA ligase activity
AL522_RS06725	COG2927	DNA polymerase III (CHI subunit)
AL522_RS06730	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL522_RS06735	COG0795	lipopolysaccharide-transporting ATPase activity
AL522_RS06740	COG0795	lipopolysaccharide-transporting ATPase activity
AL522_RS06760	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS06765	COG1129	ABC transporter
AL522_RS06770	COG1609	Transcriptional regulator
AL522_RS06800	COG2733	membrane
AL522_RS06805	COG0433	COG0433 Predicted ATPase
AL522_RS06895	COG0582	viral genome integration into host DNA
AL522_RS07005	COG2274	protein secretion by the type I secretion system
AL522_RS07020	COG3318	Belongs to the UPF0149 family
AL522_RS07020	COG3012	SEC-C Motif Domain Protein
AL522_RS07040	COG1126	abc transporter atp-binding protein
AL522_RS07045	COG0765	amino acid transport
AL522_RS07055	COG1609	Transcriptional regulator
AL522_RS07080	COG1942	4-Oxalocrotonate Tautomerase
AL522_RS07105	COG0477	Major facilitator Superfamily
AL522_RS07110	COG1609	Transcriptional regulator
AL522_RS07120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL522_RS07125	COG4114	ferric iron reductase
AL522_RS07130	COG3706	GGDEF domain
AL522_RS07155	COG2813	Specifically methylates the guanine in position
AL522_RS07160	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AL522_RS07165	COG0456	acetyltransferase
AL522_RS07170	COG1011	Hydrolase
AL522_RS07175	COG3726	membrane protein affecting hemolysin expression
AL522_RS07180	COG0560	Phosphoserine phosphatase
AL522_RS07195	COG0604	alcohol dehydrogenase
AL522_RS07205	COG0488	(ABC) transporter
AL522_RS07210	COG1349	DNA-binding transcription factor activity
AL522_RS07220	COG1129	ABC transporter
AL522_RS07240	COG1802	Transcriptional regulator
AL522_RS07245	COG0439	Biotin carboxylase
AL522_RS07255	COG0741	lytic transglycosylase activity
AL522_RS07265	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL522_RS07275	COG3708	Transcriptional regulator
AL522_RS07275	COG2207	Transcriptional regulator
AL522_RS07280	COG3045	CreA protein
AL522_RS07285	COG0745	RESPONSE REGULATOR receiver
AL522_RS07290	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL522_RS07295	COG0460	homoserine dehydrogenase
AL522_RS07295	COG0527	aspartate kinase activity
AL522_RS07310	COG3022	response to hydroperoxide
AL522_RS07320	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL522_RS07325	COG0477	Major facilitator Superfamily
AL522_RS07330	COG1584	GPR1 FUN34 yaaH family protein
AL522_RS07340	COG0484	heat shock protein binding
AL522_RS07350	COG0583	DNA-binding transcription factor activity
AL522_RS07355	COG0268	Binds directly to 16S ribosomal RNA
AL522_RS07360	COG0196	riboflavin kinase activity
AL522_RS07365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL522_RS07370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL522_RS07375	COG1047	Peptidyl-prolyl cis-trans
AL522_RS07380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL522_RS07385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL522_RS07390	COG0505	Belongs to the CarA family
AL522_RS07420	COG2967	ApaG domain
AL522_RS07425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL522_RS07430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL522_RS07435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL522_RS07440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL522_RS07445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL522_RS07450	COG0564	pseudouridine synthase activity
AL522_RS07455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL522_RS07460	COG0417	DNA replication proofreading
AL522_RS07465	COG0586	Pfam SNARE associated Golgi protein
AL522_RS07475	COG1178	ABC-type Fe3 transport system permease component
AL522_RS07480	COG4143	(ABC) transporter
AL522_RS07490	COG2814	Major facilitator Superfamily
AL522_RS07495	COG0066	3-isopropylmalate dehydratase activity
AL522_RS07500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL522_RS07510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL522_RS07515	COG0028	Belongs to the TPP enzyme family
AL522_RS07530	COG2001	Belongs to the MraZ family
AL522_RS07545	COG0768	penicillin binding
AL522_RS07555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL522_RS07570	COG0772	Belongs to the SEDS family
AL522_RS07580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL522_RS07585	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL522_RS07595	COG0849	cell division
AL522_RS07600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL522_RS07605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL522_RS07620	COG0494	nUDIX hydrolase
AL522_RS07625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL522_RS07635	COG0237	dephospho-CoA kinase activity
AL522_RS07640	COG0516	GMP reductase activity
AL522_RS07645	COG1459	type II secretion system
AL522_RS07650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL522_RS07655	COG4969	Belongs to the N-Me-Phe pilin family
AL522_RS07665	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL522_RS07670	COG3725	Membrane protein required for beta-lactamase induction
AL522_RS07675	COG3940	Belongs to the glycosyl hydrolase 43 family
AL522_RS07680	COG2211	Major facilitator Superfamily
AL522_RS07685	COG1113	amino acid transport
AL522_RS07690	COG2186	Transcriptional regulator
AL522_RS07695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL522_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL522_RS07705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL522_RS07735	COG3479	Phenolic acid decarboxylase
AL522_RS07745	COG3112	Uncharacterised protein family (UPF0231)
AL522_RS07755	COG3395	kinase activity
AL522_RS07760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL522_RS07765	COG1349	DNA-binding transcription factor activity
AL522_RS07780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AL522_RS07795	COG0626	cystathionine gamma-synthase activity
AL522_RS07805	COG0288	reversible hydration of carbon dioxide
AL522_RS07810	COG1131	(ABC) transporter
AL522_RS07815	COG0842	Transport permease protein
AL522_RS07825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL522_RS07830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL522_RS07835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL522_RS07840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL522_RS07845	COG0617	tRNA 3'-terminal CCA addition
AL522_RS07855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL522_RS07865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL522_RS07870	COG1643	Atp-dependent helicase
AL522_RS07875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL522_RS07880	COG4774	siderophore transport
AL522_RS07885	COG1120	ATPase activity
AL522_RS07890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL522_RS07905	COG0316	Belongs to the HesB IscA family
AL522_RS07915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL522_RS07920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL522_RS07930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL522_RS07935	COG3835	regulator
AL522_RS07950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL522_RS07960	COG0052	Belongs to the universal ribosomal protein uS2 family
AL522_RS07965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL522_RS07970	COG0528	UMP kinase activity
AL522_RS07975	COG0233	cytoplasmic translational termination
AL522_RS07980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL522_RS07985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL522_RS07990	COG0575	Belongs to the CDS family
AL522_RS08000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS08005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL522_RS08015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL522_RS08025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL522_RS08030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL522_RS08040	COG0825	malonyl-CoA metabolic process
AL522_RS08045	COG1982	Orn Lys Arg decarboxylase major
AL522_RS08050	COG0346	lactoylglutathione lyase activity
AL522_RS08055	COG0037	tRNA processing
AL522_RS08065	COG4568	rho-dependent transcription termination
AL522_RS08080	COG0442	prolyl-tRNA aminoacylation
AL522_RS08085	COG1720	tRNA m6t6A37 methyltransferase activity
AL522_RS08100	COG2011	ABC-type metal ion transport system permease component
AL522_RS08105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL522_RS08110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL522_RS08140	COG0583	DNA-binding transcription factor activity
AL522_RS08145	COG3021	interspecies interaction between organisms
AL522_RS08150	COG0741	lytic transglycosylase activity
AL522_RS08150	COG1388	LysM domain
AL522_RS08155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL522_RS08160	COG2226	methyltransferase
AL522_RS08165	COG0328	RNA-DNA hybrid ribonuclease activity
AL522_RS08180	COG1953	Uracil, thiamine, allantoin
AL522_RS08230	COG0765	amino acid transport
AL522_RS08235	COG0765	amino acid transport
AL522_RS08245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL522_RS08260	COG2351	hydroxyisourate hydrolase activity
AL522_RS08265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL522_RS08270	COG0436	Aminotransferase
AL522_RS08280	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AL522_RS08285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AL522_RS08305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL522_RS08310	COG0121	glutamine amidotransferase
AL522_RS08315	COG3034	peptidoglycan biosynthetic process
AL522_RS08330	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS08335	COG1129	ABC transporter
AL522_RS08340	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL522_RS08350	COG1073	alpha beta
AL522_RS08360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL522_RS08365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL522_RS08370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL522_RS08415	COG1278	Cold shock
AL522_RS08420	COG0840	transmembrane signaling receptor activity
AL522_RS08430	COG0784	Response regulator, receiver
AL522_RS08430	COG0835	chemotaxis
AL522_RS08440	COG0513	Belongs to the DEAD box helicase family
AL522_RS08450	COG0402	S-adenosylhomocysteine deaminase activity
AL522_RS08460	COG2807	transmembrane transport
AL522_RS08465	COG1620	l-lactate permease
AL522_RS08470	COG2186	Transcriptional regulator
AL522_RS08480	COG1764	response to oxidative stress
AL522_RS08500	COG5001	Diguanylate cyclase
AL522_RS08520	COG3250	beta-galactosidase activity
AL522_RS08540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL522_RS08550	COG3416	Protein conserved in bacteria
AL522_RS08555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL522_RS08565	COG1414	Transcriptional regulator
AL522_RS08580	COG4126	flavin adenine dinucleotide binding
AL522_RS08585	COG3123	guanosine phosphorylase activity
AL522_RS08590	COG2974	May be involved in recombination
AL522_RS08595	COG1940	carbohydrate kinase activity
AL522_RS08635	COG0419	ATPase involved in DNA repair
AL522_RS08640	COG0420	3'-5' exonuclease activity
AL522_RS08645	COG0745	RESPONSE REGULATOR receiver
AL522_RS08650	COG5002	protein histidine kinase activity
AL522_RS08660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL522_RS08670	COG1113	amino acid transport
AL522_RS08680	COG0483	inositol monophosphate 1-phosphatase activity
AL522_RS08690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL522_RS08695	COG0582	viral genome integration into host DNA
AL522_RS08780	COG1396	sequence-specific DNA binding
AL522_RS08920	COG3728	DNA packaging
AL522_RS08920	COG5484	DNA packaging
AL522_RS08925	COG5410	chromosome segregation
AL522_RS09065	COG0343	queuine tRNA-ribosyltransferase activity
AL522_RS09070	COG1862	Preprotein translocase
AL522_RS09075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL522_RS09080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL522_RS09085	COG4238	major outer membrane lipoprotein
AL522_RS09090	COG1652	LysM domain
AL522_RS09100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL522_RS09100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL522_RS09105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL522_RS09110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL522_RS09115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL522_RS09120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL522_RS09125	COG0667	Aldo Keto reductase
AL522_RS09130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL522_RS09135	COG0142	geranyltranstransferase activity
AL522_RS09140	COG1722	exodeoxyribonuclease VII activity
AL522_RS09155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL522_RS09160	COG1666	GTP binding
AL522_RS09165	COG2814	Major facilitator Superfamily
AL522_RS09170	COG0109	protoheme IX farnesyltransferase activity
AL522_RS09175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL522_RS09180	COG1845	cytochrome c oxidase, subunit III
AL522_RS09185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL522_RS09190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL522_RS09195	COG2223	nitrite transmembrane transporter activity
AL522_RS09200	COG3056	Lipoprotein
AL522_RS09205	COG0271	Belongs to the BolA IbaG family
AL522_RS09230	COG0776	regulation of translation
AL522_RS09235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL522_RS09240	COG1555	photosystem II stabilization
AL522_RS09245	COG0824	Thioesterase
AL522_RS09255	COG4533	DNA binding
AL522_RS09265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL522_RS09270	COG1522	sequence-specific DNA binding
AL522_RS09275	COG1132	(ABC) transporter
AL522_RS09280	COG1132	(ABC) transporter
AL522_RS09285	COG0347	Belongs to the P(II) protein family
AL522_RS09290	COG0004	ammonium transporteR
AL522_RS09295	COG1946	Acyl-CoA thioesterase
AL522_RS09300	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL522_RS09305	COG3695	enzyme binding
AL522_RS09330	COG1121	(ABC) transporter
AL522_RS09335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL522_RS09340	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL522_RS09345	COG0254	rRNA binding
AL522_RS09350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL522_RS09355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL522_RS09360	COG1309	transcriptional regulator
AL522_RS09365	COG2261	transglycosylase associated protein
AL522_RS09375	COG2832	Protein of unknown function (DUF454)
AL522_RS09380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL522_RS09385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL522_RS09390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL522_RS09395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL522_RS09400	COG0326	Molecular chaperone. Has ATPase activity
AL522_RS09410	COG0563	adenylate kinase activity
AL522_RS09415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL522_RS09420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL522_RS09425	COG4651	solute:proton antiporter activity
AL522_RS09425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL522_RS09430	COG0737	Belongs to the 5'-nucleotidase family
AL522_RS09450	COG3735	TraB family
AL522_RS09455	COG2217	Heavy metal translocating P-type atpase
AL522_RS09460	COG0789	Transcriptional regulator
AL522_RS09465	COG1585	Membrane protein implicated in regulation of membrane protease activity
AL522_RS09470	COG0330	HflC and HflK could
AL522_RS09475	COG3118	belongs to the thioredoxin family
AL522_RS09480	COG0300	oxidoreductase activity
AL522_RS09485	COG2755	lipolytic protein G-D-S-L family
AL522_RS09490	COG4181	ATPase activity
AL522_RS09495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL522_RS09500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL522_RS09505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL522_RS09515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL522_RS09520	COG0215	cysteine-tRNA ligase activity
AL522_RS09525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL522_RS09530	COG2501	S4 domain
AL522_RS09535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL522_RS09580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AL522_RS09600	COG0598	Magnesium transport protein CorA
AL522_RS09610	COG1597	lipid kinase activity
AL522_RS09630	COG0628	permease
AL522_RS09645	COG2323	membrane
AL522_RS09660	COG1063	alcohol dehydrogenase
AL522_RS09670	COG0814	amino acid
AL522_RS09685	COG0561	phosphatase activity
AL522_RS09690	COG1454	alcohol dehydrogenase
AL522_RS09695	COG2610	gluconate transmembrane transporter activity
AL522_RS09705	COG1278	Cold shock
AL522_RS09725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL522_RS09740	COG1126	abc transporter atp-binding protein
AL522_RS09745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL522_RS09750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL522_RS09755	COG0321	lipoyl(octanoyl) transferase activity
AL522_RS09760	COG2921	Belongs to the UPF0250 family
AL522_RS09765	COG1686	Belongs to the peptidase S11 family
AL522_RS09770	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL522_RS09775	COG0772	Belongs to the SEDS family
AL522_RS09780	COG0768	penicillin binding
AL522_RS09785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL522_RS09790	COG0799	negative regulation of ribosome biogenesis
AL522_RS09800	COG1466	dna polymerase III delta subunit
AL522_RS09805	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL522_RS09810	COG0495	leucyl-tRNA aminoacylation
AL522_RS09815	COG2888	peptidyl-tyrosine sulfation
AL522_RS09820	COG1126	abc transporter atp-binding protein
AL522_RS09825	COG0765	amino acid transport
AL522_RS09830	COG0765	amino acid transport
AL522_RS09840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL522_RS09855	COG1702	phosphate starvation-inducible protein PhoH
AL522_RS09860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL522_RS09865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL522_RS09905	COG0367	asparagine synthase
AL522_RS09910	COG0647	UMP catabolic process
AL522_RS09915	COG1846	Transcriptional regulator
AL522_RS09915	COG1940	carbohydrate kinase activity
AL522_RS09920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL522_RS09925	COG0363	glucosamine-6-phosphate deaminase activity
AL522_RS09935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL522_RS09945	COG0735	belongs to the Fur family
AL522_RS09950	COG0716	FMN binding
AL522_RS09960	COG0596	Alpha beta hydrolase
AL522_RS09965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL522_RS09970	COG0033	Phosphoglucomutase
AL522_RS09975	COG0745	RESPONSE REGULATOR receiver
AL522_RS09985	COG3272	Protein of unknown function (DUF1722)
AL522_RS10000	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL522_RS10005	COG1984	allophanate hydrolase subunit 2
AL522_RS10025	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL522_RS10035	COG0372	Belongs to the citrate synthase family
AL522_RS10045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL522_RS10050	COG1053	succinate dehydrogenase
AL522_RS10055	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL522_RS10060	COG0567	Dehydrogenase, E1 component
AL522_RS10065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL522_RS10070	COG0045	succinate-CoA ligase (ADP-forming) activity
AL522_RS10075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL522_RS10080	COG1271	oxidase subunit
AL522_RS10085	COG1294	oxidase, subunit
AL522_RS10090	COG4890	Cyd operon protein YbgT
AL522_RS10095	COG3790	cyd operon protein YbgE
AL522_RS10100	COG0824	Thioesterase
AL522_RS10105	COG0811	peptide transport
AL522_RS10110	COG0848	biopolymer transport protein
AL522_RS10115	COG3064	Membrane
AL522_RS10125	COG2885	chlorophyll binding
AL522_RS10130	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL522_RS10160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL522_RS10165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL522_RS10175	COG1230	cation diffusion facilitator family transporter
AL522_RS10180	COG0784	Response regulator, receiver
AL522_RS10180	COG2198	Histidine kinase
AL522_RS10180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS10180	COG2205	protein histidine kinase activity
AL522_RS10195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL522_RS10200	COG0588	phosphoglycerate mutase activity
AL522_RS10205	COG2017	converts alpha-aldose to the beta-anomer
AL522_RS10215	COG1085	galactose-1-phosphate uridylyltransferase
AL522_RS10220	COG1119	ATPase activity
AL522_RS10225	COG2005	Transcriptional regulator
AL522_RS10225	COG3585	molybdate ion transport
AL522_RS10235	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL522_RS10240	COG4149	molybdate abc transporter
AL522_RS10250	COG0561	phosphatase activity
AL522_RS10255	COG2706	6-phosphogluconolactonase activity
AL522_RS10265	COG1881	PFAM PEBP family protein
AL522_RS10275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL522_RS10285	COG2226	methyltransferase
AL522_RS10290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL522_RS10300	COG0556	nucleotide-excision repair
AL522_RS10315	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL522_RS10320	COG0315	cyclic pyranopterin monophosphate synthase activity
AL522_RS10325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL522_RS10330	COG0314	molybdopterin synthase activity
AL522_RS10345	COG0670	Belongs to the BI1 family
AL522_RS10350	COG0392	lysyltransferase activity
AL522_RS10355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL522_RS10360	COG3568	Endonuclease Exonuclease Phosphatase
AL522_RS10370	COG0513	Belongs to the DEAD box helicase family
AL522_RS10375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL522_RS10385	COG0306	phosphate transporter
AL522_RS10390	COG1376	ErfK ybiS ycfS ynhG family protein
AL522_RS10395	COG3387	PFAM Glycoside hydrolase 15-related
AL522_RS10400	COG0586	Pfam SNARE associated Golgi protein
AL522_RS10410	COG1686	Belongs to the peptidase S11 family
AL522_RS10415	COG3264	Mechanosensitive ion channel
AL522_RS10415	COG1511	domain protein
AL522_RS10430	COG0277	FAD linked oxidase domain protein
AL522_RS10435	COG1472	Belongs to the glycosyl hydrolase 3 family
AL522_RS10465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AL522_RS10470	COG0477	Major facilitator Superfamily
AL522_RS10475	COG1732	Glycine betaine
AL522_RS10480	COG1174	glycine betaine transport
AL522_RS10485	COG1125	glycine betaine transport
AL522_RS10490	COG1174	glycine betaine transport
AL522_RS10495	COG0789	Transcriptional regulator
AL522_RS10515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL522_RS10520	COG1473	amidohydrolase
AL522_RS10525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL522_RS10530	COG2986	histidine ammonia-lyase
AL522_RS10545	COG0402	S-adenosylhomocysteine deaminase activity
AL522_RS10550	COG1228	amidohydrolase
AL522_RS10575	COG2986	histidine ammonia-lyase
AL522_RS10585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL522_RS10590	COG1126	abc transporter atp-binding protein
AL522_RS10595	COG0765	amino acid transport
AL522_RS10600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS10605	COG0783	Belongs to the Dps family
AL522_RS10615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AL522_RS10625	COG1321	iron dependent repressor
AL522_RS10630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL522_RS10635	COG1566	PFAM secretion protein HlyD family protein
AL522_RS10640	COG2814	Major facilitator Superfamily
AL522_RS10650	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL522_RS10655	COG0488	(ABC) transporter
AL522_RS10665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL522_RS10670	COG0303	'Molybdopterin
AL522_RS10680	COG4172	Belongs to the ABC transporter superfamily
AL522_RS10690	COG0601	transmembrane transport
AL522_RS10720	COG2133	pyrroloquinoline quinone binding
AL522_RS10730	COG1686	Belongs to the peptidase S11 family
AL522_RS10735	COG0671	phosphoesterase, PA-phosphatase related
AL522_RS10760	COG0778	Nitroreductase
AL522_RS10775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL522_RS10780	COG3842	ATPase activity
AL522_RS10785	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL522_RS10790	COG1177	transmembrane transport
AL522_RS10800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL522_RS10805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS10810	COG4160	amino acid transport
AL522_RS10815	COG4215	(ABC) transporter
AL522_RS10820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS10825	COG1126	abc transporter atp-binding protein
AL522_RS10840	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL522_RS10845	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL522_RS10850	COG0028	Belongs to the TPP enzyme family
AL522_RS10855	COG2431	L-lysine efflux transmembrane transporter activity
AL522_RS10860	COG3593	DNA synthesis involved in DNA repair
AL522_RS10865	COG1278	Cold shock
AL522_RS10870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL522_RS10875	COG0542	response to heat
AL522_RS10880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL522_RS10885	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL522_RS10890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL522_RS10895	COG4988	ABC transporter
AL522_RS10900	COG0492	ferredoxin-NADP+ reductase activity
AL522_RS10910	COG1674	ftsk spoiiie
AL522_RS10910	COG3107	peptidoglycan biosynthetic process
AL522_RS10915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL522_RS10920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL522_RS10925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL522_RS10930	COG0477	Major facilitator Superfamily
AL522_RS10935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL522_RS10940	COG1882	Formate acetyltransferase
AL522_RS10945	COG2116	formate transmembrane transporter activity
AL522_RS10950	COG1944	ATP diphosphatase activity
AL522_RS10955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL522_RS10965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL522_RS10970	COG0539	negative regulation of cytoplasmic translation
AL522_RS10975	COG0776	regulation of translation
AL522_RS10980	COG0658	competence protein
AL522_RS10980	COG2333	competence protein COMEC
AL522_RS10990	COG1663	tetraacyldisaccharide 4'-kinase activity
AL522_RS10995	COG3214	Protein conserved in bacteria
AL522_RS11000	COG2835	tetraacyldisaccharide 4'-kinase activity
AL522_RS11005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL522_RS11010	COG3173	Aminoglycoside phosphotransferase
AL522_RS11015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL522_RS11020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL522_RS11025	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL522_RS11030	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL522_RS11040	COG2989	Protein conserved in bacteria
AL522_RS11045	COG3108	Peptidase M15
AL522_RS11050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL522_RS11065	COG0017	Asparaginyl-tRNA synthetase
AL522_RS11070	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL522_RS11075	COG0308	aminopeptidase N
AL522_RS11080	COG1116	anion transmembrane transporter activity
AL522_RS11085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL522_RS11090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL522_RS11095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL522_RS11100	COG0431	NADPH-dependent FMN reductase
AL522_RS11105	COG1216	Glycosyl transferase, family 2
AL522_RS11115	COG0167	dihydroorotate dehydrogenase activity
AL522_RS11125	COG3217	Mosc domain protein beta barrel domain protein
AL522_RS11125	COG0633	Ferredoxin
AL522_RS11130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL522_RS11130	COG0116	Belongs to the methyltransferase superfamily
AL522_RS11135	COG0488	(ABC) transporter
AL522_RS11140	COG2995	paraquat-inducible protein a
AL522_RS11145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL522_RS11145	COG3008	intermembrane lipid transfer
AL522_RS11150	COG3009	Protein conserved in bacteria
AL522_RS11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL522_RS11160	COG1067	ATP-dependent peptidase activity
AL522_RS11165	COG3120	sequence-specific DNA binding
AL522_RS11180	COG3070	regulator of competence-specific genes
AL522_RS11185	COG1289	transmembrane transporter activity
AL522_RS11190	COG3304	Inner membrane component domain
AL522_RS11195	COG0210	DNA helicase
AL522_RS11210	COG1832	CoA-binding protein
AL522_RS11220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL522_RS11230	COG2920	part of a sulfur-relay system
AL522_RS11235	COG0670	Belongs to the BI1 family
AL522_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS11270	COG3729	General stress protein
AL522_RS11280	COG2233	PERMEase
AL522_RS11285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL522_RS11290	COG2267	carboxylic ester hydrolase activity
AL522_RS11310	COG1309	transcriptional regulator
AL522_RS11320	COG1113	amino acid transport
AL522_RS11330	COG2197	response regulator
AL522_RS11345	COG2197	response regulator
AL522_RS11355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL522_RS11395	COG3238	Protein conserved in bacteria
AL522_RS11400	COG1247	-acetyltransferase
AL522_RS11405	COG1396	sequence-specific DNA binding
AL522_RS11450	COG0659	secondary active sulfate transmembrane transporter activity
AL522_RS11460	COG0840	transmembrane signaling receptor activity
AL522_RS11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL522_RS11525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL522_RS11540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL522_RS11545	COG0463	Glycosyl transferase, family 2
AL522_RS11570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL522_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS11585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL522_RS11595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL522_RS11610	COG2943	transferase activity, transferring hexosyl groups
AL522_RS11615	COG5645	(Lipo)protein
AL522_RS11630	COG1560	Kdo2-lipid A biosynthetic process
AL522_RS11635	COG1054	Belongs to the UPF0176 family
AL522_RS11640	COG2353	YceI-like domain
AL522_RS11645	COG3038	cytochrome b561
AL522_RS11670	COG0418	dihydroorotase activity
AL522_RS11680	COG2999	glutathione oxidoreductase activity
AL522_RS11685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL522_RS11700	COG0728	peptidoglycan biosynthetic process
AL522_RS11720	COG1815	bacterial-type flagellum-dependent cell motility
AL522_RS11725	COG1558	bacterial-type flagellum-dependent cell motility
AL522_RS11730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL522_RS11735	COG1749	Flagellar hook protein flgE
AL522_RS11760	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL522_RS11760	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL522_RS11770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL522_RS11775	COG1530	ribonuclease E activity
AL522_RS11775	COG1530	ribonuclease E activity
AL522_RS11780	COG0564	pseudouridine synthase activity
AL522_RS11785	COG0424	maF-like protein
AL522_RS11790	COG1399	metal-binding, possibly nucleic acid-binding protein
AL522_RS11795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL522_RS11800	COG0416	fatty acid biosynthetic process
AL522_RS11805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL522_RS11825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL522_RS11830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL522_RS11835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL522_RS11840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL522_RS11845	COG0470	DNA polymerase III
AL522_RS11850	COG0084	hydrolase, TatD family'
AL522_RS11855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL522_RS11855	COG1263	PTS System
AL522_RS11860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AL522_RS11870	COG0537	adenosine 5'-monophosphoramidase activity
AL522_RS11875	COG5633	Lipoprotein
AL522_RS11880	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
AL522_RS11900	COG1252	NADH dehydrogenase
AL522_RS11910	COG3134	Outer membrane lipoprotein
AL522_RS11915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL522_RS11925	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL522_RS11935	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL522_RS11940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL522_RS11945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL522_RS11950	COG1177	transmembrane transport
AL522_RS11965	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL522_RS11970	COG2850	peptidyl-arginine hydroxylation
AL522_RS11975	COG2205	protein histidine kinase activity
AL522_RS11980	COG0745	RESPONSE REGULATOR receiver
AL522_RS11985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL522_RS11990	COG2915	High frequency lysogenization protein hflD homolog
AL522_RS12005	COG1187	pseudouridine synthase activity
AL522_RS12010	COG0538	isocitrate dehydrogenase activity
AL522_RS12050	COG0840	transmembrane signaling receptor activity
AL522_RS12090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL522_RS12120	COG3386	PFAM SMP-30 Gluconolaconase
AL522_RS12140	COG2801	Transposase and inactivated derivatives
AL522_RS12145	COG2963	transposase activity
AL522_RS12175	COG0859	PFAM glycosyl transferase family 9
AL522_RS12215	COG0454	-acetyltransferase
AL522_RS12225	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL522_RS12235	COG2390	Transcriptional regulator
AL522_RS12240	COG3959	Transketolase, thiamine diphosphate binding domain
AL522_RS12255	COG0668	transmembrane transport
AL522_RS12260	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AL522_RS12265	COG2261	transglycosylase associated protein
AL522_RS12270	COG4774	siderophore transport
AL522_RS12285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL522_RS12300	COG3381	protein complex oligomerization
AL522_RS12305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL522_RS12310	COG0697	spore germination
AL522_RS12315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL522_RS12315	COG0519	Catalyzes the synthesis of GMP from XMP
AL522_RS12455	COG0515	serine threonine protein kinase
AL522_RS12470	COG4104	PAAR repeat-containing protein
AL522_RS12470	COG3209	COG3209 Rhs family protein
AL522_RS12480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL522_RS12510	COG3209	COG3209 Rhs family protein
AL522_RS12535	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS12540	COG4172	Belongs to the ABC transporter superfamily
AL522_RS12550	COG0601	transmembrane transport
AL522_RS12575	COG0583	DNA-binding transcription factor activity
AL522_RS12580	COG0012	GTP binding
AL522_RS12585	COG0193	aminoacyl-tRNA hydrolase activity
AL522_RS12595	COG3706	GGDEF domain
AL522_RS12600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL522_RS12605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL522_RS12610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL522_RS12615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL522_RS12620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL522_RS12635	COG2912	Transglutaminase-like superfamily
AL522_RS12645	COG0387	Pfam Sodium calcium exchanger
AL522_RS12650	COG4572	Cation transport regulator
AL522_RS12655	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AL522_RS12660	COG0515	serine threonine protein kinase
AL522_RS12700	COG3707	response regulator
AL522_RS12705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL522_RS12715	COG1116	anion transmembrane transporter activity
AL522_RS12720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL522_RS12720	COG2146	nitrite reductase [NAD(P)H] activity
AL522_RS12725	COG0243	molybdopterin cofactor binding
AL522_RS12735	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL522_RS12740	COG2336	PFAM SpoVT AbrB
AL522_RS12745	COG1349	DNA-binding transcription factor activity
AL522_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS12755	COG1879	ABC-type sugar transport system periplasmic component
AL522_RS12765	COG1129	ABC transporter
AL522_RS12770	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS12780	COG4932	domain protein
AL522_RS12795	COG1846	Transcriptional regulator
AL522_RS12810	COG5001	Diguanylate cyclase
AL522_RS12825	COG3138	arginine N-succinyltransferase
AL522_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS12840	COG2988	succinylglutamate desuccinylase activity
AL522_RS12845	COG3678	ATP-independent chaperone mediated protein folding
AL522_RS12850	COG0322	excinuclease ABC activity
AL522_RS12860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL522_RS12865	COG2814	Major facilitator Superfamily
AL522_RS12875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS12885	COG1823	symporter activity
AL522_RS12890	COG1988	membrane-bound metal-dependent
AL522_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS12905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL522_RS12915	COG3001	Fructosamine kinase
AL522_RS12925	COG3137	Salt-induced outer membrane protein
AL522_RS12930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL522_RS12940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL522_RS12950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL522_RS12960	COG0776	regulation of translation
AL522_RS12970	COG0386	Belongs to the glutathione peroxidase family
AL522_RS12980	COG0791	NLP P60 protein
AL522_RS12990	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL522_RS12995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL522_RS13000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL522_RS13005	COG0574	Belongs to the PEP-utilizing enzyme family
AL522_RS13005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL522_RS13015	COG0628	permease
AL522_RS13020	COG0277	FAD linked oxidase domain protein
AL522_RS13020	COG0247	lactate metabolic process
AL522_RS13030	COG0316	Belongs to the HesB IscA family
AL522_RS13035	COG0719	Fe-S assembly protein
AL522_RS13040	COG0396	ATPase activity
AL522_RS13045	COG0719	Fe-S assembly protein
AL522_RS13055	COG2166	iron-sulfur cluster assembly
AL522_RS13060	COG1376	ErfK ybiS ycfS ynhG family protein
AL522_RS13060	COG1388	LysM domain
AL522_RS13095	COG0307	riboflavin synthase, alpha
AL522_RS13100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL522_RS13105	COG2814	Major facilitator Superfamily
AL522_RS13110	COG0583	DNA-binding transcription factor activity
AL522_RS13115	COG1609	Transcriptional regulator
AL522_RS13120	COG0791	NLP P60 protein
AL522_RS13125	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL522_RS13135	COG0346	lactoylglutathione lyase activity
AL522_RS13140	COG1902	pentaerythritol trinitrate reductase activity
AL522_RS13145	COG1309	transcriptional regulator
AL522_RS13150	COG3313	Fe-S protein
AL522_RS13155	COG4989	oxidoreductase activity
AL522_RS13175	COG1566	PFAM secretion protein HlyD family protein
AL522_RS13190	COG3133	Outer membrane lipoprotein
AL522_RS13195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL522_RS13205	COG2200	EAL domain
AL522_RS13225	COG1309	transcriptional regulator
AL522_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS13260	COG0668	transmembrane transport
AL522_RS13270	COG0753	catalase activity
AL522_RS13275	COG3443	Belongs to the bacterial solute-binding protein 9 family
AL522_RS13280	COG2315	Protein conserved in bacteria
AL522_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS13295	COG3546	catalase activity
AL522_RS13315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL522_RS13365	COG3895	Periplasmic Protein
AL522_RS13375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL522_RS13385	COG0625	glutathione transferase activity
AL522_RS13395	COG0504	CTP synthase activity
AL522_RS13400	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS13415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL522_RS13420	COG4660	Part of a membrane complex involved in electron transport
AL522_RS13425	COG4659	FMN binding
AL522_RS13430	COG4658	electron transport chain
AL522_RS13435	COG4656	Part of a membrane complex involved in electron transport
AL522_RS13440	COG2878	Part of a membrane complex involved in electron transport
AL522_RS13445	COG4657	Part of a membrane complex involved in electron transport
AL522_RS13465	COG1879	ABC-type sugar transport system periplasmic component
AL522_RS13470	COG1129	ABC transporter
AL522_RS13475	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS13480	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS13490	COG2160	L-arabinose isomerase activity
AL522_RS13495	COG1069	ribulokinase activity
AL522_RS13500	COG1879	ABC-type sugar transport system periplasmic component
AL522_RS13510	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS13520	COG0673	inositol 2-dehydrogenase activity
AL522_RS13525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL522_RS13530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL522_RS13535	COG1263	PTS System
AL522_RS13535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL522_RS13540	COG1609	Transcriptional regulator
AL522_RS13545	COG5339	Protein conserved in bacteria
AL522_RS13550	COG1482	cell wall glycoprotein biosynthetic process
AL522_RS13555	COG0114	fumarate hydratase activity
AL522_RS13595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL522_RS13630	COG3135	benzoate transporter
AL522_RS13635	COG1396	sequence-specific DNA binding
AL522_RS13645	COG1335	isochorismatase
AL522_RS13650	COG4772	TonB-dependent receptor
AL522_RS13655	COG2084	Dehydrogenase
AL522_RS13665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL522_RS13700	COG2353	YceI-like domain
AL522_RS13705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL522_RS13710	COG0205	6-phosphofructokinase activity
AL522_RS13745	COG3011	Protein conserved in bacteria
AL522_RS13750	COG0583	DNA-binding transcription factor activity
AL522_RS13775	COG1971	Probably functions as a manganese efflux pump
AL522_RS13800	COG0640	Transcriptional regulator
AL522_RS13845	COG0444	Belongs to the ABC transporter superfamily
AL522_RS13855	COG0601	transmembrane transport
AL522_RS13860	COG0747	negative chemotaxis
AL522_RS13865	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS13890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL522_RS13910	COG2130	NADP-dependent
AL522_RS13925	COG1349	DNA-binding transcription factor activity
AL522_RS13935	COG1902	pentaerythritol trinitrate reductase activity
AL522_RS13945	COG2351	hydroxyisourate hydrolase activity
AL522_RS13955	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL522_RS13975	COG3121	Chaperone
AL522_RS13980	COG3188	usher protein
AL522_RS14015	COG3550	peptidyl-serine autophosphorylation
AL522_RS14020	COG1396	sequence-specific DNA binding
AL522_RS14040	COG1840	ABC-type Fe3 transport system, periplasmic component
AL522_RS14045	COG1609	Transcriptional regulator
AL522_RS14050	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS14055	COG3387	PFAM Glycoside hydrolase 15-related
AL522_RS14060	COG5654	RES domain protein
AL522_RS14065	COG5642	Protein of unknown function (DUF2384)
AL522_RS14085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL522_RS14090	COG0339	signal peptide processing
AL522_RS14100	COG2080	2 iron, 2 sulfur cluster binding
AL522_RS14100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL522_RS14110	COG0402	S-adenosylhomocysteine deaminase activity
AL522_RS14115	COG4221	oxidoreductase activity
AL522_RS14120	COG1742	UPF0060 membrane protein
AL522_RS14135	COG0477	Major facilitator Superfamily
AL522_RS14160	COG2233	PERMEase
AL522_RS14170	COG1940	carbohydrate kinase activity
AL522_RS14175	COG0583	DNA-binding transcription factor activity
AL522_RS14180	COG2814	Major facilitator Superfamily
AL522_RS14190	COG3038	cytochrome b561
AL522_RS14195	COG2814	Major facilitator Superfamily
AL522_RS14210	COG1309	transcriptional regulator
AL522_RS14255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL522_RS14260	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS14275	COG0583	DNA-binding transcription factor activity
AL522_RS14280	COG0747	negative chemotaxis
AL522_RS14285	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL522_RS14295	COG0436	Aminotransferase
AL522_RS14305	COG0840	transmembrane signaling receptor activity
AL522_RS14315	COG5383	Protein conserved in bacteria
AL522_RS14325	COG0583	DNA-binding transcription factor activity
AL522_RS14330	COG2840	Smr protein MutS2
AL522_RS14335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL522_RS14345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL522_RS14350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL522_RS14360	COG0531	amino acid
AL522_RS14370	COG0745	RESPONSE REGULATOR receiver
AL522_RS14375	COG2205	protein histidine kinase activity
AL522_RS14380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL522_RS14390	COG3591	Belongs to the peptidase S1B family
AL522_RS14395	COG1643	Atp-dependent helicase
AL522_RS14415	COG2911	Protein conserved in bacteria
AL522_RS14420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL522_RS14430	COG1285	pathogenesis
AL522_RS14450	COG4166	transmembrane transport
AL522_RS14455	COG2866	Carboxypeptidase
AL522_RS14460	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS14465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL522_RS14475	COG2246	polysaccharide biosynthetic process
AL522_RS14490	COG3768	UPF0283 membrane protein
AL522_RS14505	COG1983	PspC domain protein
AL522_RS14515	COG1842	Phage shock protein A
AL522_RS14520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL522_RS14530	COG0477	Major facilitator Superfamily
AL522_RS14535	COG4166	transmembrane transport
AL522_RS14550	COG3729	General stress protein
AL522_RS14560	COG4171	peptide transport system, permease
AL522_RS14570	COG4172	Belongs to the ABC transporter superfamily
AL522_RS14575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL522_RS14580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL522_RS14580	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL522_RS14595	COG0840	transmembrane signaling receptor activity
AL522_RS14600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL522_RS14600	COG1263	PTS System
AL522_RS14610	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL522_RS14615	COG1966	Carbon starvation protein
AL522_RS14620	COG2879	small protein
AL522_RS14625	COG5001	Diguanylate cyclase
AL522_RS14630	COG1024	Enoyl-CoA hydratase
AL522_RS14655	COG0023	Translation Initiation Factor
AL522_RS14660	COG0284	orotidine-5'-phosphate decarboxylase activity
AL522_RS14665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL522_RS14670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL522_RS14675	COG0671	phosphoesterase, PA-phosphatase related
AL522_RS14685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL522_RS14705	COG0616	signal peptide processing
AL522_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS14730	COG0009	L-threonylcarbamoyladenylate synthase
AL522_RS14735	COG0613	PHP domain protein
AL522_RS14745	COG0512	Glutamine amidotransferase of anthranilate synthase
AL522_RS14745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL522_RS14750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL522_RS14760	COG0133	tryptophan synthase activity
AL522_RS14775	COG3047	cAMP biosynthetic process
AL522_RS14780	COG0727	PFAM Uncharacterised protein family (UPF0153)
AL522_RS14790	COG2917	probably involved in intracellular septation
AL522_RS14805	COG2350	Protein conserved in bacteria
AL522_RS14825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL522_RS14830	COG3099	Belongs to the UPF0263 family
AL522_RS14840	COG0444	Belongs to the ABC transporter superfamily
AL522_RS14845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL522_RS14850	COG0601	transmembrane transport
AL522_RS14860	COG4166	transmembrane transport
AL522_RS14865	COG2095	MarC family integral membrane protein
AL522_RS14870	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS14870	COG1454	alcohol dehydrogenase
AL522_RS14880	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL522_RS14895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL522_RS14900	COG0745	RESPONSE REGULATOR receiver
AL522_RS14905	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL522_RS14915	COG0788	formyltetrahydrofolate deformylase activity
AL522_RS14940	COG0708	Exodeoxyribonuclease III
AL522_RS14955	COG0778	Nitroreductase
AL522_RS14960	COG0616	signal peptide processing
AL522_RS14965	COG0252	asparaginase activity
AL522_RS14970	COG1335	isochorismatase
AL522_RS14975	COG3139	Protein of unknown function (DUF1315)
AL522_RS14980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL522_RS14995	COG0656	L-ascorbic acid biosynthetic process
AL522_RS15000	COG3713	MltA-interacting MipA family protein
AL522_RS15005	COG2766	serine protein kinase
AL522_RS15010	COG2718	Belongs to the UPF0229 family
AL522_RS15035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL522_RS15040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL522_RS15045	COG2719	SpoVR family
AL522_RS15065	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL522_RS15075	COG0850	regulation of cytokinetic process
AL522_RS15080	COG2894	cell division
AL522_RS15085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL522_RS15090	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL522_RS15095	COG0318	PFAM AMP-dependent synthetase and ligase
AL522_RS15100	COG3065	identical protein binding
AL522_RS15110	COG1199	ATP-dependent helicase activity
AL522_RS15125	COG0251	oxidation-reduction process
AL522_RS15130	COG3140	Belongs to the UPF0181 family
AL522_RS15145	COG1760	l-serine dehydratase
AL522_RS15150	COG2200	EAL domain
AL522_RS15155	COG1253	flavin adenine dinucleotide binding
AL522_RS15160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL522_RS15160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS15165	COG3715	PTS system
AL522_RS15170	COG3716	PTS system mannose fructose sorbose family IID component
AL522_RS15180	COG2226	methyltransferase
AL522_RS15205	COG1414	Transcriptional regulator
AL522_RS15210	COG2814	Major facilitator Superfamily
AL522_RS15215	COG0501	Belongs to the peptidase M48B family
AL522_RS15225	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL522_RS15230	COG1956	GAF domain-containing protein
AL522_RS15235	COG2995	paraquat-inducible protein a
AL522_RS15240	COG3008	intermembrane lipid transfer
AL522_RS15245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL522_RS15245	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL522_RS15255	COG3813	Protein conserved in bacteria
AL522_RS15260	COG0477	Major facilitator Superfamily
AL522_RS15265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL522_RS15295	COG2755	lipolytic protein G-D-S-L family
AL522_RS15295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL522_RS15310	COG1064	alcohol dehydrogenase
AL522_RS15355	COG4974	Belongs to the 'phage' integrase family
AL522_RS15365	COG1276	copper resistance
AL522_RS15370	COG2372	response to copper ion
AL522_RS15380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL522_RS15385	COG1770	oligopeptidase
AL522_RS15390	COG2979	Protein of unknown function (DUF533)
AL522_RS15400	COG0800	Aldolase
AL522_RS15405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL522_RS15410	COG1737	Transcriptional regulator
AL522_RS15415	COG0469	pyruvate kinase activity
AL522_RS15425	COG1560	Kdo2-lipid A biosynthetic process
AL522_RS15430	COG0739	heme binding
AL522_RS15435	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL522_RS15445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL522_RS15450	COG2255	four-way junction helicase activity
AL522_RS15455	COG0632	four-way junction helicase activity
AL522_RS15465	COG0217	transcriptional regulatory protein
AL522_RS15470	COG0494	nUDIX hydrolase
AL522_RS15480	COG1801	Protein of unknown function DUF72
AL522_RS15485	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AL522_RS15490	COG2226	methyltransferase
AL522_RS15495	COG0500	methyltransferase
AL522_RS15515	COG3142	Participates in the control of copper homeostasis
AL522_RS15520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AL522_RS15525	COG3102	Protein conserved in bacteria
AL522_RS15535	COG0583	DNA-binding transcription factor activity
AL522_RS15540	COG0667	Aldo Keto reductase
AL522_RS15555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL522_RS15565	COG0745	RESPONSE REGULATOR receiver
AL522_RS15575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL522_RS15580	COG0840	transmembrane signaling receptor activity
AL522_RS15585	COG0840	transmembrane signaling receptor activity
AL522_RS15595	COG0835	chemotaxis
AL522_RS15630	COG1877	trehalose-phosphatase activity
AL522_RS15640	COG0745	RESPONSE REGULATOR receiver
AL522_RS15655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL522_RS15665	COG1702	phosphate starvation-inducible protein PhoH
AL522_RS15675	COG2822	iron ion transport
AL522_RS15685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL522_RS15690	COG0506	proline dehydrogenase activity
AL522_RS15690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL522_RS15690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL522_RS15695	COG4763	Acyl-transferase
AL522_RS15700	COG1126	abc transporter atp-binding protein
AL522_RS15705	COG0765	amino acid transport
AL522_RS15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS15740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL522_RS15745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL522_RS15750	COG1516	flagellar protein fliS
AL522_RS15760	COG0366	Alpha amylase catalytic
AL522_RS15825	COG1677	Flagellar hook-basal body complex protein FliE
AL522_RS15830	COG1766	The M ring may be actively involved in energy transduction
AL522_RS15835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL522_RS15840	COG1317	bacterial-type flagellum organization
AL522_RS15850	COG2882	bacterial-type flagellum organization
AL522_RS15860	COG1580	Controls the rotational direction of flagella during chemotaxis
AL522_RS15870	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL522_RS15880	COG1338	Plays a role in the flagellum-specific transport system
AL522_RS15885	COG1987	bacterial-type flagellum assembly
AL522_RS15900	COG0840	transmembrane signaling receptor activity
AL522_RS15920	COG1215	transferase activity, transferring glycosyl groups
AL522_RS15925	COG5475	Uncharacterized small protein (DUF2158)
AL522_RS15930	COG2354	Protein conserved in bacteria
AL522_RS15940	COG3727	T/G mismatch-specific endonuclease activity
AL522_RS15945	COG0270	DNA (cytosine-5-)-methyltransferase activity
AL522_RS15955	COG1418	mRNA catabolic process
AL522_RS15985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL522_RS16020	COG2261	transglycosylase associated protein
AL522_RS16050	COG5444	nuclease activity
AL522_RS16070	COG2706	6-phosphogluconolactonase activity
AL522_RS16075	COG0534	Mate efflux family protein
AL522_RS16080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL522_RS16095	COG2252	PERMEase
AL522_RS16120	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS16125	COG1129	ABC transporter
AL522_RS16135	COG3639	organic phosphonate transmembrane transporter activity
AL522_RS16145	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AL522_RS16160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AL522_RS16165	COG3454	Phosphonate metabolism
AL522_RS16170	COG4778	phosphonate C-P lyase system protein PhnL
AL522_RS16175	COG4107	phosphonate C-P lyase system protein PhnK
AL522_RS16180	COG3627	carbon phosphorus lyase activity
AL522_RS16185	COG3626	phosphonate metabolism
AL522_RS16190	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AL522_RS16195	COG3624	Phosphonate C-P lyase system protein PhnG
AL522_RS16200	COG2188	Transcriptional regulator
AL522_RS16210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL522_RS16280	COG0300	oxidoreductase activity
AL522_RS16285	COG0028	Belongs to the TPP enzyme family
AL522_RS16305	COG1522	sequence-specific DNA binding
AL522_RS16315	COG1473	amidohydrolase
AL522_RS16320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL522_RS16335	COG4172	Belongs to the ABC transporter superfamily
AL522_RS16340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL522_RS16345	COG0601	transmembrane transport
AL522_RS16355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL522_RS16365	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS16370	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS16375	COG0583	DNA-binding transcription factor activity
AL522_RS16390	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL522_RS16395	COG1129	ABC transporter
AL522_RS16425	COG4773	Receptor
AL522_RS16450	COG0456	acetyltransferase
AL522_RS16465	COG0840	transmembrane signaling receptor activity
AL522_RS16480	COG3122	Protein conserved in bacteria
AL522_RS16485	COG1309	transcriptional regulator
AL522_RS16490	COG0277	FAD linked oxidase domain protein
AL522_RS16495	COG1216	Glycosyl transferase, family 2
AL522_RS16495	COG1442	glycosyl transferase family 8
AL522_RS16500	COG0673	inositol 2-dehydrogenase activity
AL522_RS16530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL522_RS16545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL522_RS16550	COG1609	Transcriptional regulator
AL522_RS16555	COG2926	Belongs to the UPF0265 family
AL522_RS16560	COG1289	transmembrane transporter activity
AL522_RS16575	COG2925	Exonuclease
AL522_RS16580	COG2610	gluconate transmembrane transporter activity
AL522_RS16585	COG3622	Belongs to the hyi family
AL522_RS16590	COG0235	Class ii aldolase
AL522_RS16595	COG3395	kinase activity
AL522_RS16600	COG2084	Dehydrogenase
AL522_RS16605	COG1349	DNA-binding transcription factor activity
AL522_RS16610	COG0531	amino acid
AL522_RS16615	COG0174	glutamine synthetase
AL522_RS16620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL522_RS16625	COG1396	sequence-specific DNA binding
AL522_RS16625	COG1917	Cupin 2, conserved barrel domain protein
AL522_RS16630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL522_RS16635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL522_RS16640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL522_RS16645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL522_RS16650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL522_RS16660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL522_RS16665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL522_RS16675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL522_RS16675	COG0140	phosphoribosyl-ATP diphosphatase activity
AL522_RS16680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL522_RS16695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL522_RS16715	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AL522_RS16785	COG0463	Glycosyl transferase, family 2
AL522_RS16825	COG2982	Protein involved in outer membrane biogenesis
AL522_RS16830	COG0717	Belongs to the dCTP deaminase family
AL522_RS16835	COG0572	uridine kinase
AL522_RS16845	COG5002	protein histidine kinase activity
AL522_RS16845	COG3447	MASE1 domain protein
AL522_RS16845	COG5001	Diguanylate cyclase
AL522_RS16850	COG0443	Heat shock 70 kDa protein
AL522_RS16860	COG0667	Aldo Keto reductase
AL522_RS16865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL522_RS16875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL522_RS16885	COG2205	protein histidine kinase activity
AL522_RS16890	COG0745	RESPONSE REGULATOR receiver
AL522_RS16895	COG0826	peptidase U32
AL522_RS16905	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS16910	COG1063	alcohol dehydrogenase
AL522_RS16915	COG2271	Major facilitator Superfamily
AL522_RS16920	COG0246	Mannitol dehydrogenase
AL522_RS16925	COG1802	Transcriptional regulator
AL522_RS16930	COG0351	phosphomethylpyrimidine kinase
AL522_RS16935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL522_RS16970	COG3634	alkyl hydroperoxide reductase activity
AL522_RS16985	COG0489	protein tyrosine kinase activity
AL522_RS16990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL522_RS16990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL522_RS16995	COG1380	Effector of murein hydrolase LrgA
AL522_RS17000	COG1346	cytolysis
AL522_RS17005	COG0295	cytidine deaminase activity
AL522_RS17010	COG0281	malic enzyme
AL522_RS17015	COG2949	membrane
AL522_RS17025	COG1129	ABC transporter
AL522_RS17040	COG2311	Membrane
AL522_RS17050	COG0477	Major facilitator Superfamily
AL522_RS17055	COG0583	DNA-binding transcription factor activity
AL522_RS17070	COG1120	ATPase activity
AL522_RS17075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL522_RS17080	COG0833	amino acid
AL522_RS17085	COG0583	DNA-binding transcription factor activity
AL522_RS17095	COG2855	membrane
AL522_RS17100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL522_RS17105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL522_RS17105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL522_RS17105	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL522_RS17110	COG1105	Belongs to the carbohydrate kinase PfkB family
AL522_RS17115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS17115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS17125	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL522_RS17130	COG0523	cobalamin synthesis protein
AL522_RS17135	COG0671	phosphoesterase, PA-phosphatase related
AL522_RS17145	COG0791	NLP P60 protein
AL522_RS17150	COG2200	EAL domain
AL522_RS17155	COG4166	transmembrane transport
AL522_RS17160	COG4174	ABC transporter (Permease)
AL522_RS17165	COG4239	(ABC) transporter, permease
AL522_RS17170	COG4172	Belongs to the ABC transporter superfamily
AL522_RS17180	COG2814	Major facilitator Superfamily
AL522_RS17190	COG1061	Type III restriction enzyme res subunit
AL522_RS17195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL522_RS17205	COG3082	Protein of unknown function (DUF1414)
AL522_RS17220	COG0582	viral genome integration into host DNA
AL522_RS17355	COG3311	Transcriptional regulator
AL522_RS17380	COG4615	Cyclic peptide transporter
AL522_RS17385	COG3145	DNA-N1-methyladenine dioxygenase activity
AL522_RS17405	COG1132	(ABC) transporter
AL522_RS17430	COG2223	nitrite transmembrane transporter activity
AL522_RS17435	COG0642	Histidine kinase
AL522_RS17435	COG2198	Histidine kinase
AL522_RS17440	COG2197	response regulator
AL522_RS17455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL522_RS17460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL522_RS17470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL522_RS17480	COG4575	ribosome binding
AL522_RS17490	COG2153	protein acetylation
AL522_RS17495	COG1007	ATP synthesis coupled electron transport
AL522_RS17500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL522_RS17505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL522_RS17510	COG0713	ATP synthesis coupled electron transport
AL522_RS17515	COG0839	Belongs to the complex I subunit 6 family
AL522_RS17525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL522_RS17535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AL522_RS17545	COG0649	NAD binding
AL522_RS17545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL522_RS17560	COG0583	DNA-binding transcription factor activity
AL522_RS17565	COG0436	Aminotransferase
AL522_RS17570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL522_RS17575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL522_RS17580	COG3013	Belongs to the UPF0304 family
AL522_RS17585	COG3092	negative regulation of chromosome organization
AL522_RS17590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL522_RS17595	COG0280	phosphate acetyltransferase
AL522_RS17595	COG0857	belongs to the CobB CobQ family
AL522_RS17600	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AL522_RS17605	COG0625	glutathione transferase activity
AL522_RS17610	COG1090	epimerase
AL522_RS17615	COG4598	ABC transporter
AL522_RS17620	COG4160	amino acid transport
AL522_RS17635	COG0163	prenyltransferase activity
AL522_RS17640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL522_RS17645	COG1286	toxin biosynthetic process
AL522_RS17650	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL522_RS17655	COG0285	dihydrofolate synthase activity
AL522_RS17665	COG0586	Pfam SNARE associated Golgi protein
AL522_RS17675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL522_RS17685	COG2207	Transcriptional regulator
AL522_RS17700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL522_RS17710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL522_RS17725	COG3101	peptidyl-lysine hydroxylation
AL522_RS17730	COG0730	response to heat
AL522_RS17740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL522_RS17755	COG2062	phosphohistidine phosphatase, SixA
AL522_RS17760	COG1024	Enoyl-CoA hydratase
AL522_RS17760	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL522_RS17765	COG0183	Belongs to the thiolase family
AL522_RS17770	COG3691	Protein conserved in bacteria
AL522_RS17775	COG2067	long-chain fatty acid transport protein
AL522_RS17785	COG3088	subunit of a heme lyase
AL522_RS17785	COG4235	cytochrome complex assembly
AL522_RS17790	COG3088	subunit of a heme lyase
AL522_RS17790	COG4235	cytochrome complex assembly
AL522_RS17800	COG1138	Cytochrome C-type biogenesis protein
AL522_RS17805	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL522_RS17810	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL522_RS17815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL522_RS17820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL522_RS17830	COG2116	formate transmembrane transporter activity
AL522_RS17865	COG3584	3D domain protein
AL522_RS17865	COG1388	LysM domain
AL522_RS17900	COG2223	nitrite transmembrane transporter activity
AL522_RS17940	COG0436	Aminotransferase
AL522_RS17950	COG3275	phosphorelay sensor kinase activity
AL522_RS17955	COG3279	Response regulator of the LytR AlgR family
AL522_RS17960	COG0837	glucose binding
AL522_RS17965	COG3961	Belongs to the TPP enzyme family
AL522_RS17970	COG0667	Aldo Keto reductase
AL522_RS17980	COG1914	H( )-stimulated, divalent metal cation uptake system
AL522_RS17985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL522_RS18000	COG2116	formate transmembrane transporter activity
AL522_RS18005	COG3415	Transposase
AL522_RS18010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL522_RS18045	COG0583	DNA-binding transcription factor activity
AL522_RS18050	COG0385	Bile acid
AL522_RS18055	COG3530	Putative quorum-sensing-regulated virulence factor
AL522_RS18065	COG3115	cell septum assembly
AL522_RS18070	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL522_RS18090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL522_RS18100	COG2205	protein histidine kinase activity
AL522_RS18105	COG0745	RESPONSE REGULATOR receiver
AL522_RS18110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL522_RS18115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL522_RS18120	COG4208	sulfate ABC transporter
AL522_RS18125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AL522_RS18145	COG0456	acetyltransferase
AL522_RS18160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL522_RS18165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL522_RS18170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL522_RS18175	COG5342	invasion associated locus B
AL522_RS18180	COG0494	nUDIX hydrolase
AL522_RS18195	COG3850	Histidine kinase
AL522_RS18200	COG2197	response regulator
AL522_RS18205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL522_RS18210	COG1393	Belongs to the ArsC family
AL522_RS18215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL522_RS18225	COG0400	carboxylic ester hydrolase activity
AL522_RS18230	COG1444	tRNA N-acetyltransferase activity
AL522_RS18235	COG2321	neutral zinc metallopeptidase
AL522_RS18240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL522_RS18245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL522_RS18250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL522_RS18255	COG2716	regulation of RNA biosynthetic process
AL522_RS18260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL522_RS18265	COG3706	GGDEF domain
AL522_RS18280	COG4783	chaperone-mediated protein folding
AL522_RS18285	COG1393	Belongs to the ArsC family
AL522_RS18290	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL522_RS18295	COG2233	PERMEase
AL522_RS18305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL522_RS18310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL522_RS18315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL522_RS18325	COG0573	inorganic phosphate transmembrane transporter activity
AL522_RS18340	COG0500	methyltransferase
AL522_RS18350	COG2239	Acts as a magnesium transporter
AL522_RS18380	COG0516	GMP reductase activity
AL522_RS18380	COG0517	IMP dehydrogenase activity
AL522_RS18385	COG1570	exodeoxyribonuclease VII activity
AL522_RS18400	COG4993	Dehydrogenase
AL522_RS18405	COG1645	bacterial-type flagellum-dependent swarming motility
AL522_RS18410	COG1160	GTP binding
AL522_RS18415	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS18420	COG2976	Protein conserved in bacteria
AL522_RS18425	COG0124	histidyl-tRNA synthetase
AL522_RS18435	COG1426	Protein conserved in bacteria
AL522_RS18445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL522_RS18450	COG0105	UTP biosynthetic process
AL522_RS18455	COG4953	penicillin-binding protein 1C
AL522_RS18460	COG2373	Large extracellular alpha-helical protein
AL522_RS18465	COG2897	thiosulfate sulfurtransferase activity
AL522_RS18475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL522_RS18485	COG1959	2 iron, 2 sulfur cluster binding
AL522_RS18495	COG0483	inositol monophosphate 1-phosphatase activity
AL522_RS18505	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AL522_RS18515	COG3711	transcriptional antiterminator
AL522_RS18520	COG2814	Major facilitator Superfamily
AL522_RS18525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL522_RS18530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL522_RS18530	COG1017	nitric oxide dioxygenase activity
AL522_RS18535	COG0347	Belongs to the P(II) protein family
AL522_RS18540	COG2204	response regulator
AL522_RS18545	COG3170	Tfp pilus assembly protein FimV
AL522_RS18550	COG2205	protein histidine kinase activity
AL522_RS18555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL522_RS18555	COG0047	phosphoribosylformylglycinamidine synthase activity
AL522_RS18560	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL522_RS18570	COG0560	Phosphoserine phosphatase
AL522_RS18575	COG1737	Transcriptional regulator
AL522_RS18580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL522_RS18585	COG0736	holo-[acyl-carrier-protein] synthase activity
AL522_RS18590	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL522_RS18605	COG0571	ribonuclease III activity
AL522_RS18615	COG0481	GTPase activity
AL522_RS18620	COG3086	response to oxidative stress
AL522_RS18625	COG3026	antisigma factor binding
AL522_RS18640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL522_RS18645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL522_RS18650	COG0513	Belongs to the DEAD box helicase family
AL522_RS18660	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL522_RS18665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL522_RS18670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL522_RS18675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL522_RS18680	COG0497	DNA recombination
AL522_RS18685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS18690	COG2914	Belongs to the UPF0125 (RnfH) family
AL522_RS18695	COG2867	negative regulation of translational initiation
AL522_RS18700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL522_RS18710	COG0582	viral genome integration into host DNA
AL522_RS18770	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AL522_RS18810	COG0673	inositol 2-dehydrogenase activity
AL522_RS18830	COG0673	inositol 2-dehydrogenase activity
AL522_RS18845	COG1012	belongs to the aldehyde dehydrogenase family
AL522_RS18855	COG3962	Belongs to the TPP enzyme family
AL522_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS18885	COG2308	Evidence 4 Homologs of previously reported genes of
AL522_RS18895	COG1305	Transglutaminase-like
AL522_RS18910	COG1278	Cold shock
AL522_RS18925	COG0747	negative chemotaxis
AL522_RS18930	COG0601	transmembrane transport
AL522_RS18935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL522_RS18940	COG0444	Belongs to the ABC transporter superfamily
AL522_RS18950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL522_RS18960	COG2040	homocysteine
AL522_RS18965	COG0833	amino acid
AL522_RS18975	COG4575	ribosome binding
AL522_RS18985	COG1780	Probably involved in ribonucleotide reductase function
AL522_RS18990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL522_RS19015	COG2814	Major facilitator Superfamily
AL522_RS19020	COG1846	Transcriptional regulator
AL522_RS19025	COG1566	PFAM secretion protein HlyD family protein
AL522_RS19030	COG2814	Major facilitator Superfamily
AL522_RS19035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL522_RS19040	COG3118	belongs to the thioredoxin family
AL522_RS19045	COG3148	PFAM DTW domain containing protein
AL522_RS19050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL522_RS19050	COG1042	CoA-binding domain protein
AL522_RS19050	COG0045	succinate-CoA ligase (ADP-forming) activity
AL522_RS19055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL522_RS19060	COG0477	Major facilitator Superfamily
AL522_RS19090	COG0542	response to heat
AL522_RS19100	COG0564	pseudouridine synthase activity
AL522_RS19105	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL522_RS19110	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL522_RS19115	COG1605	Chorismate mutase
AL522_RS19115	COG0077	Prephenate dehydratase
AL522_RS19120	COG0287	Prephenate dehydrogenase
AL522_RS19120	COG1605	Chorismate mutase
AL522_RS19125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL522_RS19135	COG0335	large ribosomal subunit rRNA binding
AL522_RS19150	COG0228	four-way junction DNA binding
AL522_RS19155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL522_RS19160	COG4137	Cytochrome C assembly protein
AL522_RS19165	COG4536	flavin adenine dinucleotide binding
AL522_RS19170	COG1854	S-ribosylhomocysteine lyase activity
AL522_RS19175	COG2918	glutathione biosynthetic process
AL522_RS19180	COG1238	metal cluster binding
AL522_RS19185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL522_RS19210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AL522_RS19220	COG2137	regulation of response to DNA damage stimulus
AL522_RS19225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL522_RS19240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL522_RS19245	COG2824	Alkylphosphonate utilization operon protein PhnA
AL522_RS19250	COG2951	lytic endotransglycosylase activity
AL522_RS19255	COG2181	nitrate reductase activity
AL522_RS19260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AL522_RS19265	COG1140	nitrate reductase beta subunit
AL522_RS19270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AL522_RS19275	COG2223	nitrite transmembrane transporter activity
AL522_RS19280	COG2197	response regulator
AL522_RS19285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL522_RS19290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL522_RS19295	COG4942	peptidase
AL522_RS19295	COG1388	LysM domain
AL522_RS19300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL522_RS19305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL522_RS19310	COG0585	pseudouridine synthase activity
AL522_RS19320	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL522_RS19325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL522_RS19340	COG2895	sulfate adenylyltransferase (ATP) activity
AL522_RS19345	COG0175	sulfate reduction
AL522_RS19350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL522_RS19350	COG1648	precorrin-2 dehydrogenase activity
AL522_RS19355	COG2234	aminopeptidase activity
AL522_RS19370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL522_RS19375	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL522_RS19380	COG0720	synthase
AL522_RS19385	COG0602	queuosine metabolic process
AL522_RS19390	COG0148	phosphopyruvate hydratase activity
AL522_RS19395	COG0504	CTP synthase activity
AL522_RS19400	COG3956	TIGRFAM MazG family protein
AL522_RS19405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL522_RS19410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL522_RS19420	COG1929	Belongs to the glycerate kinase type-1 family
AL522_RS19425	COG2084	Dehydrogenase
AL522_RS19435	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS19440	COG4948	Mandelate Racemase Muconate Lactonizing
AL522_RS19445	COG2271	Major facilitator Superfamily
AL522_RS19450	COG2721	sulfolactate sulfo-lyase activity
AL522_RS19455	COG0697	spore germination
AL522_RS19470	COG1984	allophanate hydrolase subunit 2
AL522_RS19475	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL522_RS19480	COG0436	Aminotransferase
AL522_RS19495	COG4221	oxidoreductase activity
AL522_RS19500	COG0765	amino acid transport
AL522_RS19505	COG0765	amino acid transport
AL522_RS19515	COG0716	FMN binding
AL522_RS19520	COG0564	pseudouridine synthase activity
AL522_RS19525	COG3098	single-species biofilm formation
AL522_RS19535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL522_RS19535	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL522_RS19540	COG1611	Belongs to the LOG family
AL522_RS19550	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AL522_RS19555	COG2363	Small membrane protein
AL522_RS19560	COG0583	DNA-binding transcription factor activity
AL522_RS19570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL522_RS19575	COG2166	iron-sulfur cluster assembly
AL522_RS19580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL522_RS19585	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL522_RS19605	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL522_RS19610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL522_RS19610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL522_RS19615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL522_RS19620	COG1074	ATP-dependent DNA helicase activity
AL522_RS19630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL522_RS19645	COG4795	General secretion pathway protein
AL522_RS19655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL522_RS19660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL522_RS19670	COG1051	belongs to the nudix hydrolase family
AL522_RS19675	COG3066	DNA modification
AL522_RS19680	COG0861	Integral membrane protein TerC family
AL522_RS19690	COG0667	Aldo Keto reductase
AL522_RS19705	COG0583	DNA-binding transcription factor activity
AL522_RS19710	COG2814	Major facilitator Superfamily
AL522_RS19725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL522_RS19735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL522_RS19740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL522_RS19745	COG4974	Belongs to the 'phage' integrase family
AL522_RS19750	COG0716	FMN binding
AL522_RS19760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL522_RS19770	COG1272	protein, Hemolysin III
AL522_RS19775	COG1737	Transcriptional regulator
AL522_RS19780	COG2723	6-phospho-beta-galactosidase activity
AL522_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
AL522_RS19790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL522_RS19790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL522_RS19805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL522_RS19810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL522_RS19815	COG0006	proline dipeptidase activity
AL522_RS19825	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL522_RS19835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL522_RS19840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL522_RS19850	COG0583	DNA-binding transcription factor activity
AL522_RS19855	COG2968	Membrane
AL522_RS19860	COG1279	arginine transmembrane transporter activity
AL522_RS19865	COG0668	transmembrane transport
AL522_RS19870	COG0191	fructose-bisphosphate aldolase activity
AL522_RS19875	COG0126	phosphoglycerate kinase activity
AL522_RS19880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL522_RS19885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL522_RS19890	COG0501	Belongs to the peptidase M48B family
AL522_RS19895	COG3753	Protein conserved in bacteria
AL522_RS19905	COG1166	arginine decarboxylase activity
AL522_RS19915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL522_RS19920	COG2814	Major facilitator Superfamily
AL522_RS19940	COG2356	endonuclease I
AL522_RS19945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL522_RS19955	COG1678	Uncharacterized ACR, COG1678
AL522_RS19965	COG2805	Type II/IV secretion system protein
AL522_RS19970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL522_RS19975	COG0762	integral membrane protein
AL522_RS19980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL522_RS19985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL522_RS19995	COG3171	Protein conserved in bacteria
AL522_RS20005	COG1194	a g-specific adenine glycosylase
AL522_RS20015	COG0741	lytic transglycosylase activity
AL522_RS20020	COG1982	Orn Lys Arg decarboxylase major
AL522_RS20025	COG0604	alcohol dehydrogenase
AL522_RS20030	COG1546	Belongs to the CinA family
AL522_RS20035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL522_RS20040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL522_RS20045	COG4558	Periplasmic binding protein
AL522_RS20050	COG3720	iron ion transport
AL522_RS20065	COG1695	Transcriptional regulator
AL522_RS20070	COG2375	cellular response to nickel ion
AL522_RS20080	COG3708	Transcriptional regulator
AL522_RS20080	COG2207	Transcriptional regulator
AL522_RS20090	COG1294	oxidase, subunit
AL522_RS20095	COG1271	oxidase subunit
AL522_RS20100	COG1733	regulation of RNA biosynthetic process
AL522_RS20105	COG0702	epimerase
AL522_RS20115	COG3685	Protein conserved in bacteria
AL522_RS20120	COG3685	Protein conserved in bacteria
AL522_RS20125	COG3729	General stress protein
AL522_RS20130	COG2199	diguanylate cyclase activity
AL522_RS20155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL522_RS20160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL522_RS20170	COG0084	hydrolase, TatD family'
AL522_RS20175	COG4667	esterase of the alpha-beta hydrolase superfamily
AL522_RS20180	COG2823	Periplasmic or secreted lipoprotein
AL522_RS20185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL522_RS20190	COG1473	amidohydrolase
AL522_RS20195	COG0700	Nucleoside recognition
AL522_RS20200	COG3366	ferrous iron transmembrane transporter activity
AL522_RS20205	COG1528	Iron-storage protein
AL522_RS20215	COG2271	Major facilitator Superfamily
AL522_RS20225	COG1609	Transcriptional regulator
AL522_RS20230	COG3300	MHYT domain
AL522_RS20230	COG5001	Diguanylate cyclase
AL522_RS20235	COG4297	protein containing double-stranded beta helix domain
AL522_RS20245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL522_RS20290	COG0848	biopolymer transport protein
AL522_RS20300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL522_RS20325	COG2207	Transcriptional regulator
AL522_RS20330	COG0656	L-ascorbic acid biosynthetic process
AL522_RS20335	COG2132	Multicopper oxidase
AL522_RS20345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL522_RS20355	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL522_RS20360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL522_RS20365	COG0583	DNA-binding transcription factor activity
AL522_RS20370	COG0187	DNA topoisomerase II activity
AL522_RS20375	COG3150	esterase
AL522_RS20380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AL522_RS20385	COG3151	Protein conserved in bacteria
AL522_RS20390	COG0494	nUDIX hydrolase
AL522_RS20400	COG5463	Belongs to the UPF0441 family
AL522_RS20405	COG0754	glutathionylspermidine amidase activity
AL522_RS20410	COG3384	dioxygenase
AL522_RS20420	COG2960	long-chain fatty acid transporting porin activity
AL522_RS20435	COG3025	triphosphatase activity
AL522_RS20440	COG4991	sh3 domain protein
AL522_RS20445	COG0617	tRNA 3'-terminal CCA addition
AL522_RS20450	COG1968	undecaprenyl-diphosphatase activity
AL522_RS20455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL522_RS20470	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL522_RS20475	COG0358	DNA primase activity
AL522_RS20485	COG3663	DNA glycosylase
AL522_RS20535	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL522_RS20630	COG4695	Portal protein
AL522_RS20705	COG4974	Belongs to the 'phage' integrase family
AL522_RS20715	COG3550	peptidyl-serine autophosphorylation
AL522_RS20725	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL522_RS20730	COG2199	diguanylate cyclase activity
AL522_RS20735	COG0659	secondary active sulfate transmembrane transporter activity
AL522_RS20740	COG0288	reversible hydration of carbon dioxide
AL522_RS20745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AL522_RS20755	COG1902	pentaerythritol trinitrate reductase activity
AL522_RS20755	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL522_RS20760	COG2813	Specifically methylates the guanine in position
AL522_RS20765	COG1451	nucleotide metabolic process
AL522_RS20770	COG0038	chloride channel
AL522_RS20775	COG0673	inositol 2-dehydrogenase activity
AL522_RS20785	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL522_RS20790	COG2721	sulfolactate sulfo-lyase activity
AL522_RS20805	COG2271	Major facilitator Superfamily
AL522_RS20815	COG0586	Pfam SNARE associated Golgi protein
AL522_RS20825	COG1422	Protein of unknown function (DUF1090)
AL522_RS20830	COG4575	ribosome binding
AL522_RS20835	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AL522_RS20845	COG2259	Doxx family
AL522_RS20850	COG0435	Glutathione S-transferase
AL522_RS20860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL522_RS20865	COG3107	peptidoglycan biosynthetic process
AL522_RS20870	COG0792	nuclease activity
AL522_RS20880	COG2823	Periplasmic or secreted lipoprotein
AL522_RS20885	COG1741	Belongs to the pirin family
AL522_RS20890	COG0583	DNA-binding transcription factor activity
AL522_RS20895	COG3711	transcriptional antiterminator
AL522_RS20895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL522_RS20910	COG3964	amidohydrolase
AL522_RS20945	COG0312	modulator of DNA gyrase
AL522_RS20950	COG3028	Belongs to the UPF0307 family
AL522_RS20960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL522_RS20965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL522_RS20970	COG0840	transmembrane signaling receptor activity
AL522_RS20980	COG2707	UPF0756 membrane protein
AL522_RS20990	COG2105	PFAM AIG2 family protein
AL522_RS21000	COG0729	surface antigen
AL522_RS21005	COG1253	flavin adenine dinucleotide binding
AL522_RS21015	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL522_RS21030	COG0545	Peptidyl-prolyl cis-trans isomerase
AL522_RS21035	COG3061	Opacity-associated protein A
AL522_RS21045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL522_RS21050	COG2965	DNA replication, synthesis of RNA primer
AL522_RS21055	COG0360	Binds together with S18 to 16S ribosomal RNA
AL522_RS21065	COG1073	alpha beta
AL522_RS21070	COG0840	transmembrane signaling receptor activity
AL522_RS21080	COG1960	acyl-CoA dehydrogenase activity
AL522_RS21085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL522_RS21090	COG0557	exoribonuclease II activity
AL522_RS21100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL522_RS21105	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL522_RS21110	COG0330	HflC and HflK could
AL522_RS21115	COG0330	HflC and HflK could
AL522_RS21120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL522_RS21130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL522_RS21135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL522_RS21140	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL522_RS21145	COG0802	atpase or kinase
AL522_RS21150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL522_RS21150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL522_RS21155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL522_RS21175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL522_RS21180	COG1162	GTPase activity
AL522_RS21185	COG0688	phosphatidylethanolamine metabolic process
AL522_RS21190	COG3264	Mechanosensitive ion channel
AL522_RS21190	COG1511	domain protein
AL522_RS21195	COG0039	L-malate dehydrogenase activity
AL522_RS21200	COG1438	arginine binding
AL522_RS21220	COG2732	(Barnase) inhibitor
AL522_RS21230	COG1289	transmembrane transporter activity
AL522_RS21235	COG1566	PFAM secretion protein HlyD family protein
AL522_RS21245	COG0583	DNA-binding transcription factor activity
AL522_RS21250	COG0312	modulator of DNA gyrase
AL522_RS21255	COG3164	Protein of unknown function
AL522_RS21260	COG1530	ribonuclease E activity
AL522_RS21270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL522_RS21275	COG1792	Involved in formation and maintenance of cell shape
AL522_RS21280	COG1077	Cell shape determining protein MreB Mrl
AL522_RS21285	COG2199	diguanylate cyclase activity
AL522_RS21285	COG2200	EAL domain
AL522_RS21290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL522_RS21295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AL522_RS21300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL522_RS21305	COG0511	ligase activity, forming carbon-carbon bonds
AL522_RS21310	COG0439	Biotin carboxylase
AL522_RS21320	COG4145	pantothenate transmembrane transporter activity
AL522_RS21325	COG2264	protein methyltransferase activity
AL522_RS21335	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL522_RS21340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL522_RS21345	COG4597	amino acid ABC transporter
AL522_RS21350	COG0765	amino acid transport
AL522_RS21355	COG1126	abc transporter atp-binding protein
AL522_RS21395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL522_RS21415	COG0551	DNA topoisomerase type I activity
AL522_RS21425	COG0758	DNA mediated transformation
AL522_RS21430	COG0242	peptide deformylase activity
AL522_RS21435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL522_RS21440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL522_RS21440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL522_RS21445	COG0569	domain protein
AL522_RS21450	COG1970	mechanosensitive ion channel activity
AL522_RS21455	COG3036	rescue of stalled ribosome
AL522_RS21460	COG0789	Transcriptional regulator
AL522_RS21470	COG0203	ribosomal protein L17
AL522_RS21475	COG0202	RNA polymerase activity
AL522_RS21480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL522_RS21485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL522_RS21490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL522_RS21495	COG0201	protein transport
AL522_RS21500	COG0200	Binds to the 23S rRNA
AL522_RS21505	COG1841	ribosomal large subunit assembly
AL522_RS21510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL522_RS21515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL522_RS21525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL522_RS21530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL522_RS21545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL522_RS21565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL522_RS21580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL522_RS21585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL522_RS21595	COG0088	Forms part of the polypeptide exit tunnel
AL522_RS21605	COG0051	transcription antitermination factor activity, RNA binding
AL522_RS21610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AL522_RS21630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL522_RS21640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL522_RS21645	COG2168	tRNA wobble position uridine thiolation
AL522_RS21660	COG2964	Protein conserved in bacteria
AL522_RS21665	COG0545	Peptidyl-prolyl cis-trans isomerase
AL522_RS21670	COG2900	Belongs to the SlyX family
AL522_RS21675	COG1047	Peptidyl-prolyl cis-trans
AL522_RS21680	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AL522_RS21685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL522_RS21685	COG0475	glutathione-regulated potassium exporter activity
AL522_RS21690	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL522_RS21695	COG0488	(ABC) transporter
AL522_RS21700	COG2175	clavaminate synthase activity
AL522_RS21705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL522_RS21710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AL522_RS21715	COG4521	taurine ABC transporter
AL522_RS21730	COG0429	hydrolase of the alpha beta-hydrolase fold
AL522_RS21740	COG3954	Phosphoribulokinase
AL522_RS21745	COG1765	OsmC-like protein
AL522_RS21755	COG1289	transmembrane transporter activity
AL522_RS21760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL522_RS21770	COG2184	nucleotidyltransferase activity
AL522_RS21775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL522_RS21780	COG0738	Major facilitator superfamily
AL522_RS21785	COG0402	S-adenosylhomocysteine deaminase activity
AL522_RS21790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL522_RS21810	COG0546	phosphoglycolate phosphatase activity
AL522_RS21815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL522_RS21825	COG3266	domain, Protein
AL522_RS21830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL522_RS21835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL522_RS21845	COG4796	Type ii and iii secretion system protein
AL522_RS21870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL522_RS21875	COG0494	nUDIX hydrolase
AL522_RS21885	COG1011	Hydrolase
AL522_RS21890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL522_RS21895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL522_RS21900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL522_RS21920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL522_RS21925	COG2183	response to ionizing radiation
AL522_RS21930	COG0366	Alpha amylase catalytic
AL522_RS21940	COG2267	carboxylic ester hydrolase activity
AL522_RS21945	COG1040	competence protein
AL522_RS21950	COG0316	Belongs to the HesB IscA family
AL522_RS21950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL522_RS21955	COG1640	4-alpha-glucanotransferase
AL522_RS21965	COG1349	DNA-binding transcription factor activity
AL522_RS21975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL522_RS21980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL522_RS22010	COG0679	Auxin Efflux Carrier
AL522_RS22020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AL522_RS22030	COG0058	SHG alpha-glucan phosphorylase activity
AL522_RS22035	COG0297	glycogen (starch) synthase activity
AL522_RS22045	COG1523	belongs to the glycosyl hydrolase 13 family
AL522_RS22060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL522_RS22065	COG2095	MarC family integral membrane protein
AL522_RS22080	COG2610	gluconate transmembrane transporter activity
AL522_RS22085	COG3265	gluconokinase activity
AL522_RS22090	COG1609	Transcriptional regulator
AL522_RS22095	COG1741	Belongs to the pirin family
AL522_RS22105	COG1247	-acetyltransferase
AL522_RS22120	COG0405	Gamma-glutamyltransferase
AL522_RS22130	COG0584	glycerophosphoryl diester phosphodiesterase
AL522_RS22140	COG0395	ABC-type sugar transport system, permease component
AL522_RS22145	COG1175	transmembrane transport
AL522_RS22165	COG4177	L-phenylalanine transmembrane transporter activity
AL522_RS22185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL522_RS22190	COG2177	Part of the ABC transporter FtsEX involved in
AL522_RS22195	COG2884	Cell division ATP-binding protein ftsE
AL522_RS22200	COG0552	protein localization to endoplasmic reticulum
AL522_RS22200	COG0552	protein localization to endoplasmic reticulum
AL522_RS22205	COG0742	ribosomal rna small subunit methyltransferase
AL522_RS22210	COG3776	membrane
AL522_RS22220	COG3714	YhhN family
AL522_RS22225	COG2217	Heavy metal translocating P-type atpase
AL522_RS22230	COG0425	Belongs to the sulfur carrier protein TusA family
AL522_RS22235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL522_RS22245	COG1082	Xylose isomerase domain protein TIM barrel
AL522_RS22250	COG0673	inositol 2-dehydrogenase activity
AL522_RS22255	COG3962	Belongs to the TPP enzyme family
AL522_RS22260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL522_RS22270	COG3718	enzyme involved in inositol metabolism
AL522_RS22285	COG0477	Major facilitator Superfamily
AL522_RS22290	COG0628	permease
AL522_RS22300	COG1312	Catalyzes the dehydration of D-mannonate
AL522_RS22305	COG2200	EAL domain
AL522_RS22315	COG0113	porphobilinogen synthase activity
AL522_RS22320	COG2199	diguanylate cyclase activity
AL522_RS22325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL522_RS22335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL522_RS22340	COG2814	Major facilitator Superfamily
AL522_RS22365	COG0667	Aldo Keto reductase
AL522_RS22370	COG2081	HI0933 family
AL522_RS22375	COG0306	phosphate transporter
AL522_RS22395	COG0742	ribosomal rna small subunit methyltransferase
AL522_RS22410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL522_RS22425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL522_RS22435	COG1234	tRNA 3'-trailer cleavage
AL522_RS22440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL522_RS22460	COG2814	Major facilitator Superfamily
AL522_RS22465	COG0583	DNA-binding transcription factor activity
AL522_RS22470	COG2862	Uncharacterized protein family, UPF0114
AL522_RS22475	COG2205	protein histidine kinase activity
AL522_RS22480	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AL522_RS22485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL522_RS22490	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane