locus-tag class description FOB88_RS00025 ENOG4108MRH transcriptional regulatory protein FOB88_RS00030 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOB88_RS00040 ENOG4105DWT malate dehydrogenase (quinone) FOB88_RS00045 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FOB88_RS00055 ENOG4105DY8 decarboxylase FOB88_RS00060 ENOG4108JPW Aminotransferase FOB88_RS00145 ENOG4108DBC nitroreductase FOB88_RS00150 ENOG4105E82 cytochrome subunit of dehydrogenase FOB88_RS00165 ENOG4108RNG Permease of the drug metabolite transporter FOB88_RS00175 ENOG4108IJ9 (ABC) transporter FOB88_RS00180 ENOG4105BZ7 extracellular solute-binding protein family 1 FOB88_RS00185 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOB88_RS00205 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOB88_RS00225 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FOB88_RS00280 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOB88_RS00300 ENOG4105CDA abc transporter atp-binding protein FOB88_RS00305 ENOG4105E5Q amino acid AbC transporter FOB88_RS00310 ENOG4108HW3 (ABC) transporter FOB88_RS00325 ENOG4105F0H myo-inositol catabolism protein FOB88_RS00330 ENOG4105CIB oxidoreductase Domain protein FOB88_RS00340 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS00345 ENOG4105BZU Histidine kinase FOB88_RS00370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS00375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS00385 ENOG4108JQ6 ABC transporter FOB88_RS00390 ENOG4107S8C mandelate racemase muconate lactonizing FOB88_RS00400 ENOG4105C2W permease FOB88_RS00405 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FOB88_RS00410 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FOB88_RS00415 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOB88_RS00420 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FOB88_RS00425 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOB88_RS00430 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FOB88_RS00435 ENOG4108R86 Transcriptional regulator FOB88_RS00460 ENOG4105DTS flagellar hook-associated FOB88_RS00465 ENOG4105I03 Flagellin FOB88_RS00470 ENOG4108YYH Nadph-dependent fmn reductase FOB88_RS00500 ENOG4108J5G 6-phosphogluconate dehydrogenase FOB88_RS00530 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) FOB88_RS00535 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS00545 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FOB88_RS00550 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOB88_RS00555 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOB88_RS00560 ENOG4105C3I Nad-dependent epimerase dehydratase FOB88_RS00595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOB88_RS00600 ENOG4105BZU Histidine kinase FOB88_RS00605 ENOG4105D0S secretion protein (HlyD FOB88_RS00615 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS00650 ENOG4105DEI Mannitol dehydrogenase FOB88_RS00695 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOB88_RS00700 ENOG4105C0A alcohol dehydrogenase FOB88_RS00705 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB88_RS00725 ENOG4105CHR reductase FOB88_RS00775 ENOG4105D01 (LipO)protein FOB88_RS00785 ENOG410908U Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOB88_RS00800 ENOG4105CHR reductase FOB88_RS00805 ENOG4105C7K acetolactate synthase FOB88_RS00820 ENOG4105D82 Glutamate dehydrogenase FOB88_RS00825 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS00835 ENOG4105X2V dna damage-inducible protein FOB88_RS00850 ENOG4105CNM Receptor FOB88_RS00880 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOB88_RS00885 ENOG4105BZU Histidine kinase FOB88_RS00900 ENOG4108HCJ Hydrolase FOB88_RS00905 ENOG41072TH Protein of unknown function (DUF1479) FOB88_RS00910 ENOG4105N2W Transcriptional regulator FOB88_RS00915 ENOG4105DDV Transcriptional regulator (LacI family FOB88_RS00920 ENOG4105C5Y PTS System FOB88_RS00925 ENOG4105CS2 ec 3.2.1.21 FOB88_RS00940 ENOG4105E98 transcriptional regulator DeoR family FOB88_RS00945 ENOG4105BZU Histidine kinase FOB88_RS00960 ENOG4108MTT Glutamate-rich protein grpB FOB88_RS00965 ENOG4105FE9 pseudouridine synthase FOB88_RS00990 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FOB88_RS01000 ENOG4105C7W Xanthine dehydrogenase FOB88_RS01005 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FOB88_RS01010 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FOB88_RS01015 ENOG4105CC5 ABC transporter FOB88_RS01020 ENOG4105CC5 ABC transporter FOB88_RS01025 ENOG4105DIK (ABC) transporter FOB88_RS01040 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FOB88_RS01090 ENOG4106JVB Replication Protein FOB88_RS01095 ENOG4105C26 Dehydrogenase FOB88_RS01100 ENOG4105CKI cobalamin synthesis protein FOB88_RS01110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS01115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS01120 ENOG4105C3U ABC transporter FOB88_RS01130 ENOG4108UMN azlc family FOB88_RS01150 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOB88_RS01155 ENOG4105D06 uba thif-type nad fad binding protein FOB88_RS01165 ENOG4105CCF Lysine exporter protein (Lyse ygga) FOB88_RS01190 ENOG4108MEJ flavin reductase domain protein FOB88_RS01195 ENOG4105DQ4 alcohol dehydrogenase FOB88_RS01200 ENOG4105IJY hydroxylase FOB88_RS01205 ENOG4105FE1 phytoene synthase FOB88_RS01210 ENOG4105EWK phytoene FOB88_RS01215 ENOG4107RMN lycopene cyclase FOB88_RS01220 ENOG41087PP glycosyltransferase MGT family FOB88_RS01225 ENOG4108UK3 Polyprenyl synthetase FOB88_RS01230 ENOG4108UUE Transcriptional regulator FOB88_RS01240 ENOG4105S5I Membrane FOB88_RS01250 ENOG4105C5I Dehydrogenase FOB88_RS01255 ENOG4105CSV Glutaminase FOB88_RS01260 ENOG4105CMQ Chloride channel FOB88_RS01270 ENOG410654E Membrane FOB88_RS01280 ENOG4105CSH Transporter FOB88_RS01300 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) FOB88_RS01305 ENOG4105EXG Transcriptional regulator FOB88_RS01335 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A FOB88_RS01340 ENOG4105VGJ Virulence-associated protein FOB88_RS01360 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOB88_RS01385 ENOG4105CYW agmatinase FOB88_RS01410 ENOG4105GMB type VI secretion system effector, hcp1 family FOB88_RS01420 ENOG4108RAV Conserved protein FOB88_RS01425 ENOG4105MPK DNA polymerase III subunit theta FOB88_RS01435 ENOG4105N82 Endonuclease FOB88_RS01505 ENOG4105EQR Transposase IS116 IS110 IS902 FOB88_RS01565 ENOG4105CC0 LysR family Transcriptional regulator FOB88_RS01580 ENOG4105F5W AtP-binding protein FOB88_RS01590 ENOG4105E5H Transposase FOB88_RS01595 ENOG4108YXQ IS66 Orf2 family protein FOB88_RS01840 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 FOB88_RS01855 ENOG4105DWP Membrane FOB88_RS01860 ENOG4108XM1 transcriptional regulator AsnC family FOB88_RS01875 ENOG4108Z33 Thiol disulfide Interchange Protein FOB88_RS01915 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS01950 ENOG4108RBT type iii secretion FOB88_RS01955 ENOG4106BTR FOB88_RS01960 ENOG4105Y7Q type iii secretion FOB88_RS01970 ENOG4105YY8 Transcriptional regulator FOB88_RS01980 ENOG4108N8R Invasion protein FOB88_RS01985 ENOG4108HR8 type iii secretion FOB88_RS01995 ENOG4108JIR Flagellum-specific ATP synthase FOB88_RS02015 ENOG41075IY surface presentation of antigens protein SpaP FOB88_RS02020 ENOG4105U07 type iii secretion FOB88_RS02025 ENOG4108TN6 type iii secretion FOB88_RS02040 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE FOB88_RS02040 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE FOB88_RS02050 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC FOB88_RS02065 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOB88_RS02080 ENOG4106JVB Replication Protein FOB88_RS02110 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOB88_RS02120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOB88_RS02130 ENOG4105TNG K13735 adhesin invasin FOB88_RS02145 ENOG4107EFQ arachidonate 15-lipoxygenase FOB88_RS02185 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS02260 ENOG4105CAF HipA N-terminal domain protein FOB88_RS02275 ENOG4106RMF ParB family FOB88_RS02290 ENOG4105QZ5 OriC-binding nucleoid-associated protein FOB88_RS02300 ENOG4105MPK DNA polymerase III subunit theta FOB88_RS02320 ENOG4105N82 Endonuclease FOB88_RS02335 ENOG4108X1T PAAR repeat-containing protein FOB88_RS02415 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS02425 ENOG4105SFK cell wall hydrolase autolysin FOB88_RS02435 ENOG4108JJA ABC, transporter FOB88_RS02440 ENOG4108MBX Secretion Protein FOB88_RS02465 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB88_RS02485 ENOG4107QJE Chromosome Partitioning Protein FOB88_RS02520 ENOG4105CAU Arsenical resistance protein, ArsH FOB88_RS02540 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FOB88_RS02545 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOB88_RS02550 ENOG4105CKI cobalamin synthesis protein FOB88_RS02555 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOB88_RS02560 ENOG4108I5G Major Facilitator superfamily FOB88_RS02565 ENOG4105CPF Cell wall formation (By similarity) FOB88_RS02610 ENOG4105EKQ RNA-directed DNA polymerase FOB88_RS02635 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS02660 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB88_RS02665 ENOG4105WZK nitrite reductase NADPH small subunit FOB88_RS02670 ENOG4107QZF nitrite reductase NADPH large subunit FOB88_RS02675 ENOG41076YT nitrate reductase, gamma subunit FOB88_RS02680 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FOB88_RS02685 ENOG4108IUE nitrate reductase beta subunit FOB88_RS02690 ENOG4105CRU nitrate reductase, alpha subunit FOB88_RS02695 ENOG4107QND Nitrite extrusion protein FOB88_RS02705 ENOG4105ZEG Suppressor protein FOB88_RS02750 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS02790 ENOG4105VUH addiction module killer protein FOB88_RS02805 ENOG4105DB4 FOB88_RS02865 ENOG4105I03 Flagellin FOB88_RS02880 ENOG4105EKV Phosphonate metabolism protein FOB88_RS02885 ENOG4105FT8 Phosphonate metabolism FOB88_RS02890 ENOG4105ENV phosphonate C-P lyase system protein PhnK FOB88_RS02895 ENOG4105HRV phosphonate c-p lyase system protein phnl FOB88_RS02900 ENOG4105FD8 phosphonate metabolism protein PhnM FOB88_RS02905 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FOB88_RS02910 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FOB88_RS02920 ENOG4105EHI Phosphonate ABC transporter, periplasmic FOB88_RS02930 ENOG4105S7S phosphonate abc transporter FOB88_RS02940 ENOG4105C2J ABC transporter FOB88_RS02945 ENOG4105CNN ABC, transporter FOB88_RS02950 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOB88_RS02960 ENOG4105D2N Aldolase FOB88_RS02975 ENOG4105C7N Xanthine uracil vitamin C permease FOB88_RS02985 ENOG4105FYV Amp nucleosidase FOB88_RS02990 ENOG4105UQX Mate efflux family protein FOB88_RS03010 ENOG4106VK6 Flagellar motor protein FOB88_RS03045 ENOG4108WC9 type VI secretion system effector, hcp1 family FOB88_RS03115 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB88_RS03120 ENOG4105D9P serine threonine protein kinase FOB88_RS03270 ENOG4108YRF PTS System FOB88_RS03275 ENOG4105DM4 PTS System FOB88_RS03280 ENOG4105C8I hydrolase, family 38 FOB88_RS03285 ENOG4105ETD TRANSCRIPTIONal FOB88_RS03295 ENOG4108ZNX Heat shock protein FOB88_RS03305 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS03315 ENOG4105EHG Permease protein FOB88_RS03330 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOB88_RS03365 ENOG4105EST Metal Dependent Phosphohydrolase FOB88_RS03375 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS03380 ENOG4105DVF Cytosine-specific methyltransferase FOB88_RS03385 ENOG41090BB DNA mismatch endonuclease (vsr) FOB88_RS03395 ENOG4105CKW Inner membrane protein yedI FOB88_RS03400 ENOG4105VNZ cytoplasmic protein FOB88_RS03405 ENOG4105C3Q Glycosyl transferase, family 2 FOB88_RS03430 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS03435 ENOG4105VNT transposase (IS4 family) protein FOB88_RS03445 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOB88_RS03450 ENOG4105VS8 Flagellar biosynthetic protein fliq FOB88_RS03455 ENOG4105CN7 Flagellar biosynthetic protein FliP FOB88_RS03460 ENOG4105K0P flagellar biosynthesis protein FOB88_RS03465 ENOG4105DD5 Flagellar motor switch protein FOB88_RS03470 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOB88_RS03475 ENOG4107ZI8 flagellar basal body-associated protein flil FOB88_RS03480 ENOG4105WF4 Flagellar hook-length control protein FOB88_RS03485 ENOG4105GSA Flagellar export protein flij FOB88_RS03490 ENOG4108JIR Flagellum-specific ATP synthase FOB88_RS03495 ENOG41090PJ Flagellar assembly protein FOB88_RS03500 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOB88_RS03505 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOB88_RS03510 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOB88_RS03525 ENOG4107RES phosphoglycerol transferase I FOB88_RS03540 ENOG4105Y50 Virulence Protein FOB88_RS03545 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) FOB88_RS03555 ENOG4105JCU Inherit from NOG: (Lipo)protein FOB88_RS03565 ENOG4105E5K Alpha-amylase FOB88_RS03570 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FOB88_RS03575 ENOG4105MQ3 flagellar protein FliS FOB88_RS03580 ENOG4105DTS flagellar hook-associated FOB88_RS03585 ENOG4105I03 Flagellin FOB88_RS03590 ENOG4105I03 Flagellin FOB88_RS03595 ENOG4105I03 Flagellin FOB88_RS03625 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB88_RS03630 ENOG4108M9K flagella biosynthesis protein FliZ FOB88_RS03640 ENOG4105EAB amino acid AbC transporter FOB88_RS03645 ENOG4105E5Q amino acid AbC transporter FOB88_RS03650 ENOG4105CDA abc transporter atp-binding protein FOB88_RS03655 ENOG4105IQC Inner membrane protein YcfT FOB88_RS03660 ENOG4107VIJ nudix hydrolase FOB88_RS03665 ENOG4105IQC Inner membrane protein YcfT FOB88_RS03670 ENOG4105D0D Nitrate reductase 2, gamma subunit FOB88_RS03675 ENOG4105C26 Dehydrogenase FOB88_RS03680 ENOG4105CK7 Sodium proline symporter FOB88_RS03685 ENOG4105EKT )-iron permease FOB88_RS03690 ENOG410650H (LipO)protein FOB88_RS03695 ENOG4105DBE peroxidase FOB88_RS03700 ENOG4105D5M phosphate starvation-inducible protein FOB88_RS03710 ENOG41079KZ Major Facilitator Superfamily FOB88_RS03725 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOB88_RS03735 ENOG4108JU7 Transcriptional regulator FOB88_RS03740 ENOG4105GVF (ABC) transporter FOB88_RS03770 ENOG4107R08 Integrase FOB88_RS03855 ENOG4105CDU Replicative dna helicase FOB88_RS03865 ENOG4105HGD Antitermination protein FOB88_RS03880 ENOG4105KUS lysozyme FOB88_RS03885 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 FOB88_RS03915 ENOG4108N0N Phage Terminase Large Subunit FOB88_RS04065 ENOG4105UZW Tail fiber assembly protein FOB88_RS04075 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOB88_RS04080 ENOG4105ECM Sensor protein basS pmrB FOB88_RS04085 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOB88_RS04090 ENOG4108K4C ec 3.1.3.12 FOB88_RS04095 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FOB88_RS04100 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FOB88_RS04105 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FOB88_RS04110 ENOG4107RD7 Flagellar Motor Protein, MotA FOB88_RS04115 ENOG4105ER2 Ompa motb domain protein FOB88_RS04120 ENOG4105CBS Chea signal transduction histidine kinase FOB88_RS04125 ENOG4108V3W Chemotaxis protein, CheW FOB88_RS04130 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS04135 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS04140 ENOG4105BZU Histidine kinase FOB88_RS04145 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOB88_RS04150 ENOG4108VYJ response regulator receiver protein FOB88_RS04155 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FOB88_RS04160 ENOG4105D00 flagellar biosynthetic protein flhB FOB88_RS04165 ENOG4105D7B Flagellar biosynthesis protein flha FOB88_RS04180 ENOG4105C75 arginyL-tRNA synthetase FOB88_RS04185 ENOG4106ZCM YecM protein FOB88_RS04190 ENOG4105C87 Aminotransferase class I and II FOB88_RS04195 ENOG4106N3A copper homeostasis protein cutc FOB88_RS04210 ENOG4105N14 lysine exporter protein LysE YggA FOB88_RS04215 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FOB88_RS04220 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FOB88_RS04225 ENOG4105WJG Glutathione FOB88_RS04230 ENOG41081XQ Conserved Protein FOB88_RS04235 ENOG4105C9M aspartyl-trna synthetase FOB88_RS04240 ENOG4108TIT dATP pyrophosphohydrolase FOB88_RS04245 ENOG4105CDY transcriptional regulatory protein FOB88_RS04250 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FOB88_RS04255 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOB88_RS04260 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOB88_RS04265 ENOG4105FAV ABC, transporter FOB88_RS04275 ENOG4105NXV High-affinity zinc uptake system protein FOB88_RS04280 ENOG4105DR5 peptidase FOB88_RS04285 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FOB88_RS04295 ENOG4105CA9 Pyruvate kinase FOB88_RS04300 ENOG4106KNT transcriptional regulator FOB88_RS04305 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOB88_RS04310 ENOG4108UHU Aldolase FOB88_RS04315 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOB88_RS04320 ENOG4108Q2J Inner membrane protein YebE FOB88_RS04325 ENOG4105CUG Oligopeptidase b FOB88_RS04330 ENOG4105UMD exodeoxyribonuclease X FOB88_RS04335 ENOG4105MPK DNA polymerase III subunit theta FOB88_RS04340 ENOG4105FXM Copper resistance protein FOB88_RS04345 ENOG4108PNC copper resistance FOB88_RS04350 ENOG4105NKT exported protein FOB88_RS04370 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS04385 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOB88_RS04390 ENOG4108MGI Transcriptional regulator FOB88_RS04400 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FOB88_RS04410 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FOB88_RS04420 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOB88_RS04425 ENOG4105C94 Transporter FOB88_RS04430 ENOG4108ISG Major Facilitator FOB88_RS04435 ENOG4105XDF Protein of unknown function (DUF1272) FOB88_RS04440 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOB88_RS04445 ENOG4105DY2 Paraquat-inducible protein b FOB88_RS04450 ENOG4105H2K paraquat-inducible protein a FOB88_RS04455 ENOG4108ZGC gaf domain protein FOB88_RS04460 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FOB88_RS04465 ENOG4105CN1 protease FOB88_RS04470 ENOG4105D0M Protease HtpX homolog FOB88_RS04475 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS04485 ENOG4105TIK FOB88_RS04490 ENOG4105Q3Y exported protein FOB88_RS04510 ENOG4105DHI Methyltransferase FOB88_RS04520 ENOG4105F3R pts system mannose fructose sorbose family iid FOB88_RS04525 ENOG4105ETZ PTS System FOB88_RS04530 ENOG4105DAS pts system FOB88_RS04535 ENOG4105EE5 Membrane protein terC FOB88_RS04540 ENOG4107XTP (EAL) domain protein FOB88_RS04545 ENOG4105EJQ L-serine dehydratase FOB88_RS04550 ENOG4105P8F nudix hydrolase FOB88_RS04555 ENOG4105CRQ synthase (Component I) FOB88_RS04560 ENOG4105X5C UPF0181 protein FOB88_RS04565 ENOG4105M4H endoribonuclease L-psp FOB88_RS04575 ENOG4105DVT helicase FOB88_RS04580 ENOG41072GX Peptidase M22 Glycoprotease FOB88_RS04585 ENOG4105Y4Z Outer Membrane Lipoprotein FOB88_RS04590 ENOG4105CEY Amp-dependent synthetase and ligase FOB88_RS04595 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FOB88_RS04600 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FOB88_RS04605 ENOG4107QMS site-determining protein FOB88_RS04610 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOB88_RS04620 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FOB88_RS04625 ENOG4108ZZ3 UPF0260 protein FOB88_RS04630 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOB88_RS04635 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FOB88_RS04640 ENOG4105ED1 spovr family FOB88_RS04645 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOB88_RS04650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOB88_RS04660 ENOG4105D3Q Sugar transferase FOB88_RS04675 ENOG4106AKX UPF0229 protein FOB88_RS04680 ENOG4105CYN Serine protein kinase FOB88_RS04685 ENOG4105GNX MltA-interacting MipA family protein FOB88_RS04690 ENOG4105CV8 reductase FOB88_RS04695 ENOG4105DSB aldose 1-epimerase FOB88_RS04700 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOB88_RS04705 ENOG4105E0X reductase FOB88_RS04710 ENOG4105VUT cytoplasmic protein FOB88_RS04715 ENOG4108RWI nicotinamidase FOB88_RS04720 ENOG4105HDK L-asparaginase FOB88_RS04725 ENOG4105D07 Signal peptide peptidase, SppA FOB88_RS04730 ENOG41069NU Nitroreductase FOB88_RS04735 ENOG4108IYH Dna topoisomerase FOB88_RS04740 ENOG4105MTM Protein of unknown function (DUF1496) FOB88_RS04745 ENOG4105CGK Exodeoxyribonuclease III FOB88_RS04770 ENOG4105CIY formyltetrahydrofolate deformylase FOB88_RS04775 ENOG4105K5B UPF0225 protein FOB88_RS04780 ENOG4105D78 K07001 NTE family protein FOB88_RS04785 ENOG4105I93 response regulator FOB88_RS04790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOB88_RS04795 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOB88_RS04815 ENOG4105C0A alcohol dehydrogenase FOB88_RS04820 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FOB88_RS04825 ENOG4108J59 Extracellular solute-binding protein, family 5 FOB88_RS04830 ENOG4107QSI ABC, transporter FOB88_RS04835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS04840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS04845 ENOG4105C3U ABC transporter FOB88_RS04850 ENOG4108JQ7 (ABC) transporter FOB88_RS04855 ENOG4108W5H UPF0263 protein FOB88_RS04860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOB88_RS04875 ENOG4105K9H YciI-like protein FOB88_RS04880 ENOG410822N TonB family FOB88_RS04885 ENOG4105NAU thioesterase Superfamily protein FOB88_RS04890 ENOG4107835 probably involved in intracellular septation (By similarity) FOB88_RS04900 ENOG4105PI0 Ferredoxin FOB88_RS04905 ENOG4105EIF outer membrane protein W FOB88_RS04915 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOB88_RS04920 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOB88_RS04925 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOB88_RS04930 ENOG4108I0Q anthranilate phosphoribosyltransferase FOB88_RS04935 ENOG4108EFP Anthranilate synthase component II FOB88_RS04940 ENOG4105CRQ synthase (Component I) FOB88_RS04945 ENOG4105DB7 PHP domain protein FOB88_RS04950 ENOG4107RTD sua5 ycio yrdc ywlc family protein FOB88_RS05050 ENOG4105FE9 pseudouridine synthase FOB88_RS05055 ENOG4105D4T Citrate transporter FOB88_RS05060 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FOB88_RS05065 ENOG4105UBK short-chain dehydrogenase reductase FOB88_RS05070 ENOG4105ERU peptidase FOB88_RS05075 ENOG4105RKX Protein of unknown function (DUF2498) FOB88_RS05080 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOB88_RS05085 ENOG4107R11 Transcriptional regulator FOB88_RS05100 ENOG4107QM5 aconitate hydratase FOB88_RS05110 ENOG4105EYK Phosphatidylglycerophosphatase B FOB88_RS05115 ENOG4105Q4A inner membrane protein yciS FOB88_RS05120 ENOG4105CFV Tetratricopeptide repeat protein FOB88_RS05125 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FOB88_RS05130 ENOG4108ZJT translation initiation factor, Sui1 FOB88_RS05140 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FOB88_RS05145 ENOG4105E39 Enoyl-CoA hydratase FOB88_RS05150 ENOG4105BZU Histidine kinase FOB88_RS05160 ENOG4105D22 carbon starvation protein FOB88_RS05165 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FOB88_RS05170 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FOB88_RS05175 ENOG4105CI1 PTS System FOB88_RS05185 ENOG4105DUM transcriptional regulator, lysR family FOB88_RS05190 ENOG4105Q4T oxidoreductase FOB88_RS05195 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOB88_RS05200 ENOG4108JQ2 peptide transport system atp-binding protein FOB88_RS05205 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FOB88_RS05210 ENOG4108EU3 peptide transport system, permease FOB88_RS05215 ENOG4108I5W peptide transport system, permease protein FOB88_RS05220 ENOG4108J59 Extracellular solute-binding protein, family 5 FOB88_RS05230 ENOG4105E51 psp operon transcriptional activator FOB88_RS05235 ENOG41087YS Phage shock protein A FOB88_RS05240 ENOG4105YYT phage shock protein B FOB88_RS05245 ENOG4105FM1 phage shock protein C FOB88_RS05250 ENOG4105NNG Peripheral inner membrane phage-shock protein FOB88_RS05255 ENOG4105CM6 amino acid regulated cytosolic protein FOB88_RS05260 ENOG4106K28 UPF0283 membrane protein FOB88_RS05270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOB88_RS05275 ENOG4107S8C mandelate racemase muconate lactonizing FOB88_RS05280 ENOG4105KXI murein peptide amidase A FOB88_RS05285 ENOG4107QSI ABC, transporter FOB88_RS05295 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FOB88_RS05300 ENOG4105KT7 mgtC SapB transporter FOB88_RS05310 ENOG4105C5I Dehydrogenase FOB88_RS05315 ENOG4107H52 Dicarboxylate transport FOB88_RS05320 ENOG410689M (LipO)protein FOB88_RS05325 ENOG4105WXT Conserved Protein FOB88_RS05330 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOB88_RS05335 ENOG4105CQ7 ATP-dependent helicase FOB88_RS05340 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FOB88_RS05350 ENOG4105CTD carboxy-peptidase FOB88_RS05355 ENOG4105JJR Histidine kinase FOB88_RS05360 ENOG4107EXC regulatoR FOB88_RS05370 ENOG4105D5Q Arginine ornithine antiporter FOB88_RS05375 ENOG4105C5D exported protein FOB88_RS05380 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOB88_RS05385 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOB88_RS05390 ENOG4105Q9Y Universal stress protein FOB88_RS05395 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOB88_RS05400 ENOG4108DG9 Smr protein MutS2 FOB88_RS05405 ENOG4105DDW LysR family Transcriptional regulator FOB88_RS05410 ENOG4105D2S major facilitator superfamily FOB88_RS05415 ENOG4105E32 cytoplasmic protein FOB88_RS05430 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS05435 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOB88_RS05440 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB88_RS05445 ENOG4105KSC Transcriptional regulator, TraR DksA family FOB88_RS05460 ENOG4105F27 Major Facilitator FOB88_RS05465 ENOG4105CPW cytochrome b561 FOB88_RS05475 ENOG4105D94 Major Facilitator Superfamily FOB88_RS05480 ENOG4106NZI LysR family Transcriptional regulator FOB88_RS05485 ENOG4105DAG ROK family FOB88_RS05490 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FOB88_RS05495 ENOG4108IJ8 ABC transporter FOB88_RS05500 ENOG4105E90 ABC transporter FOB88_RS05505 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FOB88_RS05510 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component FOB88_RS05515 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS05520 ENOG4105KBG Protein of unknown function (DUF1161) FOB88_RS05525 ENOG4105M5Q UPF0482 protein FOB88_RS05535 ENOG4105EMU Dehydrogenase FOB88_RS05540 ENOG4107QUY Guanine deaminase FOB88_RS05550 ENOG4105C7W Xanthine dehydrogenase FOB88_RS05560 ENOG4105DGW oligopeptidase A FOB88_RS05565 ENOG41061H0 Monooxygenase FOB88_RS05575 ENOG41066YJ Beta-lactamase FOB88_RS05580 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOB88_RS05595 ENOG4105CT4 transporter FOB88_RS05610 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FOB88_RS05615 ENOG4105CAF HipA N-terminal domain protein FOB88_RS05625 ENOG4105DFH Transport of potassium into the cell (By similarity) FOB88_RS05630 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS05665 ENOG4105C26 Dehydrogenase FOB88_RS05705 ENOG4105CHR reductase FOB88_RS05710 ENOG4105CHR reductase FOB88_RS05720 ENOG4105CKI cobalamin synthesis protein FOB88_RS05730 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOB88_RS05735 ENOG4108QBX (LipO)protein FOB88_RS05745 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FOB88_RS05755 ENOG4105F32 YngK protein FOB88_RS05765 ENOG4105EU0 Major facilitator Superfamily FOB88_RS05775 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOB88_RS05780 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FOB88_RS05795 ENOG4107W52 maltose operon periplasmic protein FOB88_RS05805 ENOG4108IJ9 (ABC) transporter FOB88_RS05810 ENOG4107FKK extracellular solute-binding protein family 1 FOB88_RS05815 ENOG4105D56 permease protein FOB88_RS05820 ENOG4105EG2 ABC transporter, permease FOB88_RS05835 ENOG4105G6Z alkaline phosphatase FOB88_RS05845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB88_RS05855 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOB88_RS05890 ENOG4108P2H Inner membrane protein YjiG FOB88_RS05895 ENOG41074DU domain protein FOB88_RS05905 ENOG4105EMU Dehydrogenase FOB88_RS05925 ENOG4108UW5 maltose o-acetyltransferase FOB88_RS05940 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOB88_RS05945 ENOG4108RVA ribokinase FOB88_RS05950 ENOG4105NYY transcriptional regulator, RpiR FOB88_RS05955 ENOG4105CNN ABC, transporter FOB88_RS05960 ENOG4105C2J ABC transporter FOB88_RS05965 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOB88_RS05975 ENOG4105CH6 catalase FOB88_RS06015 ENOG4105D2N Aldolase FOB88_RS06030 ENOG4105CTQ phosphohexokinase FOB88_RS06035 ENOG4108YYC ycei family FOB88_RS06040 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF FOB88_RS06060 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) FOB88_RS06070 ENOG4108IGT Dipeptidase FOB88_RS06075 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOB88_RS06085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOB88_RS06090 ENOG4105CHB tonB-dependent Receptor FOB88_RS06100 ENOG4105D3W isochorismatase FOB88_RS06105 ENOG4108JCI Transcriptional regulator FOB88_RS06110 ENOG4105DKK Benzoate FOB88_RS06135 ENOG4105GGE ribonuclease FOB88_RS06140 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FOB88_RS06145 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOB88_RS06170 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) FOB88_RS06175 ENOG4105C9Q fumarate hydratase class II FOB88_RS06180 ENOG4105EIP mannose-6-phosphate isomerase FOB88_RS06185 ENOG4106J39 exported protein FOB88_RS06190 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FOB88_RS06195 ENOG4105D9R oxidoreductase FOB88_RS06205 ENOG4105CNN ABC, transporter FOB88_RS06215 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FOB88_RS06220 ENOG4105EF1 ribulokinase FOB88_RS06225 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FOB88_RS06245 ENOG4105D3G Pseudouridine synthase FOB88_RS06260 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FOB88_RS06280 ENOG4108JPW Aminotransferase FOB88_RS06300 ENOG4105CY0 Metallo-Beta-Lactamase FOB88_RS06315 ENOG4105D8X mechanosensitive ion channel FOB88_RS06330 ENOG4105ETS cytosine purines uracil thiamine allantoin FOB88_RS06335 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS06380 ENOG41062B0 ABC transporter, permease FOB88_RS06385 ENOG4107R9N ABC transporter FOB88_RS06390 ENOG4105C2J ABC transporter FOB88_RS06395 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FOB88_RS06400 ENOG4105QZ5 OriC-binding nucleoid-associated protein FOB88_RS06405 ENOG4105M9B inner membrane protein ydgK FOB88_RS06410 ENOG4105DGN Electron transport complex FOB88_RS06415 ENOG4108R3D Electron transport complex FOB88_RS06420 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) FOB88_RS06425 ENOG4105D6A Electron transport complex FOB88_RS06430 ENOG4108UQQ Electron transport complex FOB88_RS06435 ENOG4105DZB Electron transport complex FOB88_RS06440 ENOG4105CSM endonuclease III FOB88_RS06445 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOB88_RS06455 ENOG4108K3A Glutathione S-transferase FOB88_RS06465 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOB88_RS06475 ENOG410642K Lysozyme inhibitor FOB88_RS06480 ENOG4105VT2 5-hydroxyisourate hydrolase FOB88_RS06485 ENOG4105SUV lipoprotein YgdR FOB88_RS06490 ENOG4105M5B (LipO)protein FOB88_RS06500 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FOB88_RS06510 ENOG4108IND Tetr family transcriptional regulator FOB88_RS06520 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOB88_RS06525 ENOG4105KT5 UmuD protein FOB88_RS06560 ENOG4105E5J UV damage endonuclease FOB88_RS06565 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FOB88_RS06570 ENOG4105CH6 catalase FOB88_RS06575 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOB88_RS06590 ENOG4105CHR reductase FOB88_RS06600 ENOG4105BZU Histidine kinase FOB88_RS06610 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FOB88_RS06615 ENOG4108XTF Outer Membrane Lipoprotein FOB88_RS06620 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) FOB88_RS06630 ENOG4105Y49 secretion protein, HlyD family FOB88_RS06635 ENOG4105DSW Fusaric acid resistance protein FOB88_RS06645 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOB88_RS06650 ENOG4107RGM aldo keto reductase FOB88_RS06655 ENOG4105XZD Fe-S protein FOB88_RS06660 ENOG4108WUH Transcriptional regulator, TetR family FOB88_RS06665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB88_RS06670 ENOG4108UYE Lactoylglutathione lyase FOB88_RS06675 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FOB88_RS06680 ENOG4105M2J Glutaredoxin FOB88_RS06685 ENOG4105K4H Nlp p60 protein FOB88_RS06695 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS06700 ENOG4105F52 Transcriptional regulator FOB88_RS06705 ENOG4105CZQ inner membrane transport protein YdhC FOB88_RS06710 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOB88_RS06715 ENOG4108R6K riboflavin synthase, subunit alpha FOB88_RS06720 ENOG4107QI1 Mate efflux family protein FOB88_RS06740 ENOG4105CA9 Pyruvate kinase FOB88_RS06750 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOB88_RS06755 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FOB88_RS06760 ENOG4105C9B Cysteine desulfurase FOB88_RS06765 ENOG4105JRK feS assembly protein SufD FOB88_RS06770 ENOG4105C3K feS assembly ATPase SufC FOB88_RS06775 ENOG4105DIW FeS assembly protein SUFB FOB88_RS06780 ENOG4108Z4V iron-sulfur cluster assembly FOB88_RS06790 ENOG4105CQB FAD linked oxidase domain protein FOB88_RS06795 ENOG4105IPI Membrane FOB88_RS06800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOB88_RS06815 ENOG4105CNG UPF0061 protein FOB88_RS06825 ENOG4108QBX (LipO)protein FOB88_RS06835 ENOG4108V06 Glutathione peroxidase FOB88_RS06845 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FOB88_RS06850 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOB88_RS06855 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOB88_RS06870 ENOG41082NX 50s ribosomal protein l35 FOB88_RS06880 ENOG4105C22 threonyL-tRNA synthetase FOB88_RS06885 ENOG4108NE3 Salt-induced outer membrane protein FOB88_RS06890 ENOG4105P10 Uncharacterized protein ydiZ FOB88_RS06900 ENOG4107PN8 YfeABCD locus regulator FOB88_RS06905 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FOB88_RS06910 ENOG4107K5X Membrane-bound metal-dependent hydrolase FOB88_RS06915 ENOG4108ETY sodium dicarboxylate symporter FOB88_RS06925 ENOG4105VNT transposase (IS4 family) protein FOB88_RS06930 ENOG4105KKI DNA-binding transcriptional activator OsmE FOB88_RS06935 ENOG4105C2C drug resistance transporter, Bcr CflA FOB88_RS06940 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FOB88_RS06945 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS06955 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FOB88_RS06960 ENOG4108SPG Periplasmic Protein FOB88_RS06965 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FOB88_RS06970 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FOB88_RS06975 ENOG4105C26 Dehydrogenase FOB88_RS06995 ENOG4105ID0 Putative invasin FOB88_RS07000 ENOG4105CHR reductase FOB88_RS07005 ENOG4105CNN ABC, transporter FOB88_RS07010 ENOG4105C2J ABC transporter FOB88_RS07020 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOB88_RS07025 ENOG4108R85 Short chain dehydrogenase FOB88_RS07030 ENOG4105E98 transcriptional regulator DeoR family FOB88_RS07035 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB88_RS07045 ENOG4107QZF nitrite reductase NADPH large subunit FOB88_RS07050 ENOG4105D7T ABC transporter FOB88_RS07075 ENOG4108SEK ompa motb domain protein FOB88_RS07105 ENOG4105D9P serine threonine protein kinase FOB88_RS07110 ENOG4108NH8 Cation transport protein FOB88_RS07115 ENOG4105WS7 Cation transport regulator FOB88_RS07120 ENOG4105EWV Sodium calcium exchanger membrane region FOB88_RS07125 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOB88_RS07130 ENOG41063JG Transcriptional regulator FOB88_RS07135 ENOG4108YY7 Invasion gene expression up-regulator SirB FOB88_RS07140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOB88_RS07145 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOB88_RS07150 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOB88_RS07155 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FOB88_RS07160 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOB88_RS07165 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOB88_RS07175 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FOB88_RS07180 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOB88_RS07185 ENOG4105C3G gtp-binding protein FOB88_RS07190 ENOG4105DFP Integrase FOB88_RS07245 ENOG4105CNA YD repeat protein FOB88_RS07290 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase FOB88_RS07295 ENOG4108NVR Methyl-accepting chemotaxis FOB88_RS07325 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS07335 ENOG4105CIB oxidoreductase Domain protein FOB88_RS07340 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOB88_RS07345 ENOG4107QNK )-transporter FOB88_RS07365 ENOG4108V06 Glutathione peroxidase FOB88_RS07375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOB88_RS07385 ENOG4105N1F Hnh endonuclease FOB88_RS07400 ENOG4105N0E Protein of unknown function (DUF2543) FOB88_RS07405 ENOG4107QTZ amino acid FOB88_RS07415 ENOG4108M3J Dehydrogenase FOB88_RS07420 ENOG4105CPW cytochrome b561 FOB88_RS07430 ENOG4105I6B RNA polymerase FOB88_RS07450 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS07480 ENOG4105E2R ROK family FOB88_RS07495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS07500 ENOG4105ECY inositol monophosphatase FOB88_RS07505 ENOG4105DMF Dehydrogenase FOB88_RS07515 ENOG4105WAB arsR family transcriptional regulator FOB88_RS07520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB88_RS07525 ENOG4105EVH UPF0753 protein FOB88_RS07530 ENOG4108TWJ NADH dehydrogenase subunit 5 FOB88_RS07535 ENOG4105DZ2 Transcriptional regulator FOB88_RS07550 ENOG4105F0F Oxalate decarboxylase FOB88_RS07560 ENOG4105C26 Dehydrogenase FOB88_RS07570 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOB88_RS07575 ENOG4108TVT permease FOB88_RS07585 ENOG4107XHZ cytoplasmic chaperone TorD family protein FOB88_RS07590 ENOG4107SSZ Phosphatase FOB88_RS07600 ENOG4105E53 ec 3.2.1.28 FOB88_RS07605 ENOG4105Y3U Transglycosylase-associated protein FOB88_RS07610 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FOB88_RS07615 ENOG4105D64 Mechanosensitive ion channel FOB88_RS07620 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOB88_RS07625 ENOG4108IUS Transketolase FOB88_RS07630 ENOG4108HHA Transketolase FOB88_RS07635 ENOG4105DKT Transcriptional regulator FOB88_RS07640 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FOB88_RS07645 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOB88_RS07685 ENOG4105CSH Transporter FOB88_RS07690 ENOG4105FDP GntR family transcriptional regulator FOB88_RS07695 ENOG4108TFM Kinase, PfkB family FOB88_RS07700 ENOG4108KD5 ADP-ribosylation crystallin J1 FOB88_RS07705 ENOG4105EAA nucleoside FOB88_RS07715 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOB88_RS07720 ENOG4105BZS acriflavin resistance protein FOB88_RS07725 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOB88_RS07735 ENOG4105MKU Transcriptional regulator FOB88_RS07740 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FOB88_RS07775 ENOG4108TTM chaperone FOB88_RS07785 ENOG4108HMX isocitrate dehydrogenase (NADP) FOB88_RS07790 ENOG4108R99 pseudouridine synthase FOB88_RS07800 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOB88_RS07805 ENOG41075W9 High frequency lysogenization protein HflD homolog FOB88_RS07810 ENOG4107QTF adenylosuccinate lyase FOB88_RS07815 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOB88_RS07820 ENOG4105IFJ Histidine kinase FOB88_RS07825 ENOG4105EZE Cupin 4 family protein FOB88_RS07830 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOB88_RS07835 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOB88_RS07840 ENOG4105D60 lipoprotein releasing system transmembrane protein FOB88_RS07850 ENOG4105D60 lipoprotein releasing system transmembrane protein FOB88_RS07860 ENOG4108JA2 transcriptioN-repair coupling factor FOB88_RS07865 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOB88_RS07875 ENOG4107MBR 17 kDa surface antigen FOB88_RS07880 ENOG4105CEP NADH dehydrogenase FOB88_RS07885 ENOG4105D0Y UPF0227 protein FOB88_RS07890 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FOB88_RS07900 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FOB88_RS07905 ENOG41090DQ Lipoprotein FOB88_RS07910 ENOG4105K59 histidine triad (HIT) protein FOB88_RS07915 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS07920 ENOG4105CI1 PTS System FOB88_RS07925 ENOG4105F8V Hydrolase, tatD family FOB88_RS07930 ENOG4107QRG dna polymerase iii FOB88_RS07935 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOB88_RS07940 ENOG4105HHA aminodeoxychorismate lyase FOB88_RS07945 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FOB88_RS07950 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB88_RS07955 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOB88_RS07960 ENOG4105CHR reductase FOB88_RS07965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOB88_RS07970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOB88_RS07975 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOB88_RS07980 ENOG4105VGS 50s ribosomal protein l32 FOB88_RS07985 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FOB88_RS07995 ENOG4105EI2 Pseudouridine synthase FOB88_RS08000 ENOG4107QQB Ribonuclease E FOB88_RS08005 ENOG4105DTJ flagellar hook-associated protein FOB88_RS08010 ENOG4105E1Q flagellar hook-associated protein FOB88_RS08015 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOB88_RS08020 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FOB88_RS08030 ENOG4105CGA flagellar basal-body rod protein FlgG FOB88_RS08035 ENOG4108KPB Flagellar basal-body rod protein FlgF FOB88_RS08040 ENOG4105BZE flagellar hook protein, FlgE FOB88_RS08045 ENOG4105W00 Flagellar hook capping protein FOB88_RS08050 ENOG4108ZC9 flagellar basal-body rod protein flgc FOB88_RS08055 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOB88_RS08060 ENOG4105CKS Flagella basal body P-ring formation protein flgA FOB88_RS08065 ENOG4105M9M anti-sigma28 factor FlgM FOB88_RS08070 ENOG4105QVD Flagella synthesis protein FlgN FOB88_RS08075 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS08080 ENOG4105CJR Integral membrane protein (MviN FOB88_RS08085 ENOG4105EP9 oxidoreductase FOB88_RS08095 ENOG4105D9U N-acetyltransferase FOB88_RS08100 ENOG4105F3T (LipO)protein FOB88_RS08105 ENOG4105EKE dihydroorotase FOB88_RS08110 ENOG4105MEA DNA damage-inducible protein i FOB88_RS08120 ENOG4105PVA Biofilm formation regulatory protein BssS FOB88_RS08125 ENOG4105F76 Sarcosine oxidase FOB88_RS08130 ENOG4105DS1 cytochrome b561 FOB88_RS08140 ENOG4105C72 UPF0176 protein FOB88_RS08145 ENOG4105D1S lipid A biosynthesis FOB88_RS08165 ENOG4108W47 Acidic protein msyB FOB88_RS08170 ENOG4105NAC (LipO)protein FOB88_RS08175 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FOB88_RS08190 ENOG4107RZC phospholipase d FOB88_RS08210 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOB88_RS08245 ENOG4105CHH sulfate transporter FOB88_RS08315 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOB88_RS08320 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOB88_RS08325 ENOG4105WH1 Two component transcriptional regulator luxr family FOB88_RS08330 ENOG4105XVG cytoplasmic protein FOB88_RS08335 ENOG4108MVS synthase FOB88_RS08340 ENOG4105VJY transcriptional regulator FOB88_RS08365 ENOG4108R86 Transcriptional regulator FOB88_RS08385 ENOG4105XH3 FOB88_RS08390 ENOG4105C26 Dehydrogenase FOB88_RS08395 ENOG4105D6F Phosphatase FOB88_RS08410 ENOG4108MN8 Membrane FOB88_RS08415 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FOB88_RS08420 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FOB88_RS08425 ENOG4105DR4 Methyltransferase FOB88_RS08430 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) FOB88_RS08435 ENOG4105K4P CoA-binding domain protein FOB88_RS08450 ENOG41088T4 Helicase IV FOB88_RS08455 ENOG410901E Membrane FOB88_RS08460 ENOG4105EM2 membrane FOB88_RS08465 ENOG4105HP8 regulator of competence-specific genes FOB88_RS08480 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FOB88_RS08485 ENOG4105DAN ATP-dependent protease FOB88_RS08490 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FOB88_RS08495 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FOB88_RS08500 ENOG4108Q2G (LipO)protein FOB88_RS08505 ENOG4105DY2 Paraquat-inducible protein b FOB88_RS08510 ENOG4105F1S paraquat-inducible protein a FOB88_RS08515 ENOG4105C5H ABC transporter FOB88_RS08520 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOB88_RS08525 ENOG4105QVC MOSC domain-containing protein FOB88_RS08530 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FOB88_RS08535 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOB88_RS08545 ENOG4105K64 Glycosyl transferase, family 2 FOB88_RS08550 ENOG4108UZX fmn reductase FOB88_RS08555 ENOG4105GVF (ABC) transporter FOB88_RS08560 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOB88_RS08565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOB88_RS08575 ENOG4105CD8 aminopeptidase N FOB88_RS08580 ENOG4107RH7 Nicotinate phosphoribosyltransferase FOB88_RS08585 ENOG4105C5S asparaginyl-tRNA synthetase FOB88_RS08595 ENOG4105CGF Aromatic amino acid aminotransferase FOB88_RS08600 ENOG4105C5X domain protein FOB88_RS08605 ENOG4105EAQ (twin-arginine translocation) pathway signal FOB88_RS08610 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FOB88_RS08615 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FOB88_RS08620 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FOB88_RS08625 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FOB88_RS08630 ENOG4106371 Methyltransferase FOB88_RS08635 ENOG4107S90 membrAne FOB88_RS08640 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FOB88_RS08645 ENOG4105W49 UPF0434 protein FOB88_RS08650 ENOG4105T0Z Conserved Protein FOB88_RS08655 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FOB88_RS08660 ENOG4105BZ1 (ABC) transporter FOB88_RS08665 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FOB88_RS08670 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FOB88_RS08675 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOB88_RS08680 ENOG4105CAT Cytidine monophosphate kinase FOB88_RS08690 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOB88_RS08695 ENOG4105DDY UPF0142 protein ycaO FOB88_RS08700 ENOG4105TMB Formate nitrite transporter FOB88_RS08705 ENOG4105C6N Formate acetyltransferase FOB88_RS08710 ENOG4105F1A Pyruvate formate-lyase FOB88_RS08715 ENOG4108ISG Major Facilitator FOB88_RS08720 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOB88_RS08725 ENOG4105D1H recombination factor protein RarA FOB88_RS08730 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FOB88_RS08735 ENOG4105CNU cell division protein FtsK FOB88_RS08740 ENOG4105EW9 transcriptional regulator AsnC family FOB88_RS08745 ENOG4105C3M thioredoxin reductase FOB88_RS08750 ENOG4108JJ9 ABC, transporter FOB88_RS08755 ENOG4108JJ8 (ABC) transporter FOB88_RS08760 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FOB88_RS08770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB88_RS08775 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FOB88_RS08780 ENOG4105VEQ Cold shock protein FOB88_RS08785 ENOG4105CPB ATP-dependent endonuclease of the OLD family FOB88_RS08790 ENOG4105DWU Membrane FOB88_RS08795 ENOG4105C7K acetolactate synthase FOB88_RS08800 ENOG4105C5W Aldolase FOB88_RS08805 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS08810 ENOG4105K8R UPF0145 protein FOB88_RS08815 ENOG41064MM (LipO)protein FOB88_RS08820 ENOG4105E5Z arginine transporter ATP-binding subunit FOB88_RS08825 ENOG4106PMH Extracellular solute-binding protein family 3 FOB88_RS08830 ENOG4105GBT ABC transporter FOB88_RS08835 ENOG4105DMR ABC, transporter FOB88_RS08840 ENOG4106TNF Periplasmic binding protein FOB88_RS08850 ENOG4105RBQ inner membrane protein ybjO FOB88_RS08855 ENOG4105D38 putrescine abc transporter FOB88_RS08860 ENOG4105F38 ABC transporter, permease FOB88_RS08865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS08870 ENOG4107RUE extracellular solute-binding protein family 1 FOB88_RS08875 ENOG4108RMJ sensory transduction regulator FOB88_RS08880 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB88_RS08885 ENOG4108DBC nitroreductase FOB88_RS08890 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FOB88_RS08895 ENOG41090BQ Glutaredoxin FOB88_RS08905 ENOG4105D0C transport protein FOB88_RS08910 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOB88_RS08915 ENOG4105DZ1 carboxypeptidase FOB88_RS08925 ENOG4105D8V Glucose sorbosone dehydrogenase FOB88_RS08930 ENOG4107B2H carbonic anhydrase FOB88_RS08935 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FOB88_RS08945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS08950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS08955 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB88_RS08960 ENOG4108JQ6 ABC transporter FOB88_RS08965 ENOG4105D44 asparaginase FOB88_RS08970 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOB88_RS08975 ENOG4105D06 uba thif-type nad fad binding protein FOB88_RS08980 ENOG4105C5H ABC transporter FOB88_RS08990 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOB88_RS08995 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS09000 ENOG4105CW7 secretion protein, HlyD family FOB88_RS09005 ENOG4105F4P )-transporter FOB88_RS09010 ENOG4105KST dependent repressor FOB88_RS09020 ENOG4108T1M outer membrane protein x FOB88_RS09025 ENOG4107AQZ Membrane FOB88_RS09030 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FOB88_RS09035 ENOG4107R0W ABC transporter FOB88_RS09040 ENOG4105E5Q amino acid AbC transporter FOB88_RS09045 ENOG4105CDA abc transporter atp-binding protein FOB88_RS09050 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FOB88_RS09065 ENOG4105C84 Histidine ammonia-lyase FOB88_RS09095 ENOG4105CI2 imidazolone-5-propionate hydrolase FOB88_RS09100 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOB88_RS09105 ENOG41090B9 response to stress FOB88_RS09110 ENOG4105CZE histidine utilization repressor FOB88_RS09115 ENOG4105C84 Histidine ammonia-lyase FOB88_RS09125 ENOG4105DJB Major Facilitator Superfamily FOB88_RS09130 ENOG4105DIA mandelate racemase muconate lactonizing FOB88_RS09135 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS09140 ENOG4105CH2 amidohydrolase FOB88_RS09145 ENOG4108MTB glycosyl transferase family FOB88_RS09150 ENOG4105DVT helicase FOB88_RS09165 ENOG4108XDN Transcriptional regulator FOB88_RS09170 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FOB88_RS09175 ENOG4108IJ8 ABC transporter FOB88_RS09180 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FOB88_RS09185 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FOB88_RS09190 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOB88_RS09195 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS09205 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FOB88_RS09210 ENOG4105CXG d-lactate dehydrogenase FOB88_RS09215 ENOG4105EGS Mechanosensitive ion channel FOB88_RS09220 ENOG41061WM D-Alanyl-D-Alanine FOB88_RS09225 ENOG41069YE inner membrane protein yohC FOB88_RS09230 ENOG4105KHU inner membrane protein YohD FOB88_RS09235 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOB88_RS09240 ENOG4105BZP glycoside hydrolase 15-related FOB88_RS09245 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOB88_RS09255 ENOG4105CJ3 phosphate transporter FOB88_RS09260 ENOG4105CSR polyphosphate kinase 2 FOB88_RS09265 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FOB88_RS09270 ENOG4105C1J atp-dependent rna helicase FOB88_RS09275 ENOG4105I9U inner membrane protein ybhQ FOB88_RS09280 ENOG4105X23 Endonuclease Exonuclease phosphatase FOB88_RS09285 ENOG4105DZQ phospholipase D Transphosphatidylase FOB88_RS09290 ENOG4107UXM Membrane FOB88_RS09295 ENOG4105HFZ Membrane FOB88_RS09300 ENOG4107QS8 (LipO)protein FOB88_RS09305 ENOG4108ZAF Molybdopterin FOB88_RS09310 ENOG4105M00 molybdopterin converting factor, subunit 1 FOB88_RS09315 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOB88_RS09320 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOB88_RS09330 ENOG4105CHW UPF0052 protein FOB88_RS09335 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOB88_RS09340 ENOG4108IV0 ABC, transporter FOB88_RS09345 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FOB88_RS09350 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOB88_RS09360 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOB88_RS09370 ENOG4108V1U phospholipid-binding protein FOB88_RS09375 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOB88_RS09380 ENOG4108K4B hydrolase FOB88_RS09390 ENOG4105E0C molybdate abc transporter FOB88_RS09395 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOB88_RS09405 ENOG4105F4R Transcriptional regulator mode FOB88_RS09410 ENOG4105DKW ABC transporter FOB88_RS09415 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FOB88_RS09420 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOB88_RS09425 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FOB88_RS09430 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOB88_RS09435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOB88_RS09440 ENOG4105JND homeobox protein FOB88_RS09445 ENOG4108WQH regulatoR FOB88_RS09450 ENOG4105BZU Histidine kinase FOB88_RS09455 ENOG4105PGM cation diffusion facilitator family transporter FOB88_RS09460 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FOB88_RS09470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOB88_RS09480 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS09505 ENOG4105UFD tol-pal system protein YbgF FOB88_RS09510 ENOG4105KCK Peptidoglycan-associated lipoprotein FOB88_RS09520 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FOB88_RS09530 ENOG4105E02 MotA TolQ exbB proton channel FOB88_RS09535 ENOG4107YD3 Thioesterase FOB88_RS09540 ENOG4105KJB cyd operon protein YbgE FOB88_RS09550 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOB88_RS09555 ENOG4105C4M (Ubiquinol oxidase) subunit I FOB88_RS09560 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOB88_RS09565 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOB88_RS09570 ENOG4105C7S Dehydrogenase FOB88_RS09575 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOB88_RS09580 ENOG4105E33 succinate dehydrogenase FOB88_RS09585 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FOB88_RS09590 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FOB88_RS09595 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FOB88_RS09600 ENOG4105BZN citrate synthase FOB88_RS09605 ENOG41068WN FOB88_RS09615 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FOB88_RS09630 ENOG4105E7W lamb ycsf family protein FOB88_RS09635 ENOG4107R7A Allophanate hydrolase subunit 2 FOB88_RS09640 ENOG4105P4J Allophanate hydrolase, subunit 1 FOB88_RS09645 ENOG4107QNR UPF0135 protein FOB88_RS09650 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOB88_RS09655 ENOG4107SEY Conserved Protein FOB88_RS09660 ENOG4105XIQ Protein of unknown function (DUF2517) FOB88_RS09665 ENOG4105EEX Two component transcriptional regulator (Winged helix family FOB88_RS09670 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FOB88_RS09680 ENOG4105EV9 Alpha Beta Hydrolase FOB88_RS09685 ENOG4105NNH LexA regulated protein FOB88_RS09690 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FOB88_RS09695 ENOG41090R7 Ferric uptake FOB88_RS09705 ENOG4105CX6 glutaminyL-tRNA synthetase FOB88_RS09710 ENOG4105VNT transposase (IS4 family) protein FOB88_RS09715 ENOG4105CI1 PTS System FOB88_RS09720 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOB88_RS09725 ENOG4105CE4 GlcNAc 6-P deacetylase FOB88_RS09730 ENOG4105E2R ROK family FOB88_RS09735 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOB88_RS09740 ENOG4105CAQ asparagine synthetase FOB88_RS09780 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOB88_RS09785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOB88_RS09790 ENOG4105C9A Phoh family FOB88_RS09795 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOB88_RS09800 ENOG4108JU5 Magnesium and cobalt efflux protein FOB88_RS09805 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FOB88_RS09815 ENOG4107RP9 extracellular solute-binding protein, family 3 FOB88_RS09820 ENOG4105EAD ABC transporter FOB88_RS09825 ENOG4105DRP amino acid AbC transporter FOB88_RS09830 ENOG4105CDA abc transporter atp-binding protein FOB88_RS09835 ENOG4107PAI alpha helical protein FOB88_RS09840 ENOG4105C8T Leucyl-tRNA synthetase FOB88_RS09845 ENOG4108U2H Rare lipoprotein B FOB88_RS09850 ENOG4105DJF DNA polymerase III, delta' subunit FOB88_RS09860 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOB88_RS09865 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOB88_RS09870 ENOG4105CJN penicillin-binding protein FOB88_RS09875 ENOG4105CNI cell division protein FtsW FOB88_RS09880 ENOG4105K6T rare lipoprotein A FOB88_RS09885 ENOG4105DZ1 carboxypeptidase FOB88_RS09890 ENOG4108Z43 UPF0250 protein FOB88_RS09895 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOB88_RS09900 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOB88_RS09905 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FOB88_RS09920 ENOG4105VEQ Cold shock protein FOB88_RS09935 ENOG4105C6Z Gluconate FOB88_RS09940 ENOG4105C0A alcohol dehydrogenase FOB88_RS09945 ENOG4108HCJ Hydrolase FOB88_RS09955 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOB88_RS09960 ENOG4105C44 Serine transporter FOB88_RS09965 ENOG4105E2A Dehydrogenase FOB88_RS09970 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOB88_RS09975 ENOG4105F4G Membrane FOB88_RS09985 ENOG4105M0C cytoplasmic protein FOB88_RS10010 ENOG4107WN4 Polygalacturonase FOB88_RS10015 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOB88_RS10030 ENOG4107QNK )-transporter FOB88_RS10050 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FOB88_RS10065 ENOG4105CT4 transporter FOB88_RS10095 ENOG4107QSI ABC, transporter FOB88_RS10135 ENOG4105X54 addiction module antidote protein FOB88_RS10185 ENOG4105D5K Hemolysin activator protein FOB88_RS10205 ENOG4105F5W AtP-binding protein FOB88_RS10365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOB88_RS10375 ENOG410679B prophage CP4-57 regulatory protein alpA FOB88_RS10385 ENOG4105DFP Integrase FOB88_RS10395 ENOG4108SAJ Protein of unknown function (DUF1198) FOB88_RS10400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOB88_RS10405 ENOG4105WQ3 Rna-binding protein FOB88_RS10410 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOB88_RS10415 ENOG4105C8N cysteinyl-tRNA synthetase FOB88_RS10420 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FOB88_RS10435 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOB88_RS10440 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOB88_RS10445 ENOG4105CV6 ABC transporter, permease FOB88_RS10450 ENOG4108I0Y (ABC) transporter FOB88_RS10455 ENOG4108UJV acyl-CoA thioesterase i FOB88_RS10460 ENOG4105E1F short-chain dehydrogenase reductase FOB88_RS10465 ENOG4107QR8 Thioredoxin FOB88_RS10470 ENOG4107QX8 SPFH domain, Band 7 family protein FOB88_RS10475 ENOG4105G5H Membrane FOB88_RS10480 ENOG4108Z6Z Transcriptional regulator FOB88_RS10490 ENOG4105C59 p-type ATPase FOB88_RS10495 ENOG4105MBR gumn family FOB88_RS10500 ENOG4108Z66 YbaK ebsC protein FOB88_RS10515 ENOG4105CGH 5'-nucleotidase FOB88_RS10520 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOB88_RS10525 ENOG4107RE1 Inosine-guanosine kinase FOB88_RS10530 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOB88_RS10535 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOB88_RS10540 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOB88_RS10545 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FOB88_RS10550 ENOG4107QMP dna polymerase iii subunits gamma and tau FOB88_RS10555 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOB88_RS10560 ENOG4105WD1 Membrane FOB88_RS10570 ENOG4106428 Protein of unknown function (DUF2496) FOB88_RS10575 ENOG4107XI7 Tetr family transcriptional regulator FOB88_RS10580 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOB88_RS10585 ENOG4105BZS acriflavin resistance protein FOB88_RS10590 ENOG4105NRA 50s ribosomal protein l31 type b FOB88_RS10595 ENOG4105YK5 50S ribosomal protein L36 FOB88_RS10600 ENOG4105DSE periplasmic solute binding protein FOB88_RS10605 ENOG4105CC5 ABC transporter FOB88_RS10610 ENOG4105DIK (ABC) transporter FOB88_RS10620 ENOG4108UKR Biofilm formation regulator YbaJ FOB88_RS10635 ENOG41080UX Methyltransferase FOB88_RS10640 ENOG4108MNP Glycoprotein polysaccharide metabolism FOB88_RS10645 ENOG4105C29 acyl-CoA thioesterase FOB88_RS10650 ENOG4105BZU Histidine kinase FOB88_RS10655 ENOG4108YZA Nitrogen regulatory protein pii FOB88_RS10660 ENOG4105BZ1 (ABC) transporter FOB88_RS10665 ENOG4105BZ1 (ABC) transporter FOB88_RS10670 ENOG4108XM1 transcriptional regulator AsnC family FOB88_RS10680 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOB88_RS10685 ENOG4108TGP Thioesterase superfamily protein FOB88_RS10690 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FOB88_RS10695 ENOG4105EIN peptidylprolyl cis-trans isomerase FOB88_RS10700 ENOG4105K70 DNA-binding protein FOB88_RS10705 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOB88_RS10720 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOB88_RS10725 ENOG4105M85 Bola protein FOB88_RS10730 ENOG4105IEY (LipO)protein FOB88_RS10735 ENOG4105EYM Major Facilitator superfamily FOB88_RS10740 ENOG4105E2S oxidase) subunit II FOB88_RS10745 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOB88_RS10750 ENOG4105CCU oxidase (Subunit III) FOB88_RS10755 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FOB88_RS10760 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOB88_RS10765 ENOG4107RDB Major Facilitator FOB88_RS10775 ENOG4105C26 Dehydrogenase FOB88_RS10780 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOB88_RS10785 ENOG4108VPT UPF0234 protein FOB88_RS10790 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOB88_RS10795 ENOG4107S0N DJ-1 family FOB88_RS10800 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FOB88_RS10805 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOB88_RS10810 ENOG4105CTB Polyprenyl synthetase FOB88_RS10815 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOB88_RS10820 ENOG4105CPC Aldo Keto reductase FOB88_RS10825 ENOG4108ZAI phosphatidylglycerophosphatase a FOB88_RS10830 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FOB88_RS10835 ENOG4107YIM Involved in the transcription termination process (By similarity) FOB88_RS10840 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOB88_RS10845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOB88_RS10850 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOB88_RS10855 ENOG4108KIC (LipO)protein FOB88_RS10860 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB88_RS10865 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB88_RS10870 ENOG4105VIE preprotein translocase, subunit YajC FOB88_RS10875 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOB88_RS10880 ENOG4105KT5 UmuD protein FOB88_RS11005 ENOG4108TFU terminase (Small subunit) FOB88_RS11015 ENOG4105F5W AtP-binding protein FOB88_RS11090 ENOG4105NY2 NinB protein FOB88_RS11120 ENOG4105CDU Replicative dna helicase FOB88_RS11290 ENOG4108KU3 Integrase FOB88_RS11295 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOB88_RS11300 ENOG4108ZYK Acyl carrier protein phosphodiesterase FOB88_RS11310 ENOG4105D6F Phosphatase FOB88_RS11315 ENOG4105C85 amino acid FOB88_RS11320 ENOG4105CWM branched-chain amino acid transport system II carrier protein FOB88_RS11330 ENOG4105DJH phosphate FOB88_RS11335 ENOG4105BZU Histidine kinase FOB88_RS11340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOB88_RS11345 ENOG4107RH8 nuclease SbcCD subunit D FOB88_RS11350 ENOG4105EYH Exonuclease FOB88_RS11360 ENOG4105DKQ ROK family FOB88_RS11365 ENOG4105DH7 May be involved in recombination (By similarity) FOB88_RS11370 ENOG4105NBK UPF0345 protein FOB88_RS11375 ENOG4105SS3 FOB88_RS11380 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOB88_RS11385 ENOG4105G4C Periplasmic ligand-binding sensor protein FOB88_RS11390 ENOG4108UPT UPF0178 protein FOB88_RS11395 ENOG4105II7 pyrroline-5-carboxylate reductase FOB88_RS11440 ENOG4105DDV Transcriptional regulator (LacI family FOB88_RS11445 ENOG4105CS2 ec 3.2.1.21 FOB88_RS11450 ENOG4105VCP PTS System FOB88_RS11455 ENOG4105CK1 PTS System FOB88_RS11475 ENOG4108Z9K Osmotically inducible protein FOB88_RS11480 ENOG4105DMF Dehydrogenase FOB88_RS11485 ENOG41073TP transcriptional regulator FOB88_RS11490 ENOG4105DAA L-lactate FOB88_RS11495 ENOG4105DJ2 Major Facilitator Superfamily FOB88_RS11500 ENOG4107NQ8 LysR family Transcriptional regulator FOB88_RS11505 ENOG4105DZC cytosine deaminase FOB88_RS11515 ENOG4105C1J atp-dependent rna helicase FOB88_RS11530 ENOG4105VEQ Cold shock protein FOB88_RS11535 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF FOB88_RS11565 ENOG4105TIV Cryptic phage CTXphi transcriptional repressor RstR FOB88_RS11625 ENOG4105D5K Hemolysin activator protein FOB88_RS11630 ENOG4105VDH Dihydroxyacetone kinase FOB88_RS11635 ENOG4108UTZ Dihydroxyacetone kinase FOB88_RS11640 ENOG4105CMT Dihydroxyacetone kinase FOB88_RS11685 ENOG4105M7P phage repressor FOB88_RS11690 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOB88_RS11695 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOB88_RS11700 ENOG4105FCK Membrane FOB88_RS11710 ENOG4105V1F Fermentation respiration switch protein FOB88_RS11715 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FOB88_RS11720 ENOG4105CIN aminoacyl-histidine dipeptidase FOB88_RS11730 ENOG4105C7B Threonine dehydratase FOB88_RS11735 ENOG4105C2J ABC transporter FOB88_RS11740 ENOG4105CNN ABC, transporter FOB88_RS11750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOB88_RS11755 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FOB88_RS11760 ENOG4105E7A Glutamine amidotransferase FOB88_RS11770 ENOG4107QPN acyl-Coa dehydrogenase FOB88_RS11775 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOB88_RS11780 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOB88_RS11785 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOB88_RS11790 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) FOB88_RS11795 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOB88_RS11800 ENOG4105CHM Aminotransferase FOB88_RS11810 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FOB88_RS11830 ENOG4105C5R Aminotransferase FOB88_RS11840 ENOG4105E5Q amino acid AbC transporter FOB88_RS11860 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOB88_RS11880 ENOG4105ETT transcriptional Regulator, LysR family FOB88_RS11890 ENOG4105CWC Acetylornithine deacetylase FOB88_RS11900 ENOG4105KME endoribonuclease L-psp FOB88_RS11905 ENOG4105H3G oxidoreductase FOB88_RS11910 ENOG4105C5Q Transcriptional regulator FOB88_RS11930 ENOG4105MP9 class II Aldolase FOB88_RS11940 ENOG410633P Hydantoin racemase FOB88_RS11950 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FOB88_RS11955 ENOG410787A Pts system, glucitol sorbitol-specific FOB88_RS11960 ENOG4105DZY Pts system, glucitol sorbitol-specific FOB88_RS11965 ENOG4105VI0 Pts system, glucitol sorbitol-specific FOB88_RS11970 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FOB88_RS11975 ENOG4105J92 DNA-binding transcriptional activator GutM FOB88_RS11980 ENOG410804X Transcriptional regulator FOB88_RS11985 ENOG4105C2X Arabinose 5-phosphate isomerase FOB88_RS11990 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOB88_RS12000 ENOG4107RZZ dna polymerase iii epsilon subunit FOB88_RS12010 ENOG4105D1A Methyltransferase FOB88_RS12015 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOB88_RS12020 ENOG4105E9H Lytic Murein transglycosylase FOB88_RS12025 ENOG4107NA1 Endonuclease Exonuclease phosphatase FOB88_RS12030 ENOG4105HEI LysR family (Transcriptional regulator FOB88_RS12060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB88_RS12065 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOB88_RS12070 ENOG4105C34 Pseudouridine synthase FOB88_RS12075 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOB88_RS12080 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FOB88_RS12095 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOB88_RS12110 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOB88_RS12120 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOB88_RS12125 ENOG4105K5M 30s ribosomal protein S16 FOB88_RS12130 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FOB88_RS12135 ENOG4106KVJ cytochrome C assembly protein FOB88_RS12140 ENOG4108JU6 CBS domain protein FOB88_RS12145 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FOB88_RS12150 ENOG4105D9M gamma-glutamylcysteine synthetase FOB88_RS12155 ENOG4105W39 Membrane FOB88_RS12160 ENOG4107VXZ Hydrolase FOB88_RS12190 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FOB88_RS12195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOB88_RS12205 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOB88_RS12210 ENOG4107TH8 cina domain protein FOB88_RS12220 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOB88_RS12225 ENOG4105CVE Lytic murein transglycosylase FOB88_RS12230 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOB88_RS12245 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB88_RS12250 ENOG4108K5P (LipO)protein FOB88_RS12255 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOB88_RS12260 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FOB88_RS12265 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FOB88_RS12270 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOB88_RS12280 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOB88_RS12285 ENOG4105N0Z inner membrane protein ygbE FOB88_RS12290 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) FOB88_RS12295 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FOB88_RS12300 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FOB88_RS12305 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB88_RS12310 ENOG4108MXK alkaline phosphatase isozyme conversion FOB88_RS12330 ENOG4108HW3 (ABC) transporter FOB88_RS12335 ENOG4105EAD ABC transporter FOB88_RS12340 ENOG4105DRP amino acid AbC transporter FOB88_RS12355 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FOB88_RS12360 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOB88_RS12365 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOB88_RS12375 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOB88_RS12380 ENOG4105F0N pyrophosphate phospho-hydrolase FOB88_RS12385 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOB88_RS12405 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOB88_RS12410 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOB88_RS12415 ENOG4105DXN mazG family FOB88_RS12420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOB88_RS12425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOB88_RS12430 ENOG4105BZU Histidine kinase FOB88_RS12435 ENOG4105BZW Glycerate kinase FOB88_RS12440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOB88_RS12445 ENOG4105CNV Aldolase FOB88_RS12450 ENOG4105EQX glucarate dehydratase FOB88_RS12455 ENOG4105EQX glucarate dehydratase FOB88_RS12460 ENOG4105DJB Major Facilitator Superfamily FOB88_RS12465 ENOG4105CTX dehydratase FOB88_RS12470 ENOG4105QDK Flavodoxin FOB88_RS12475 ENOG4105DR9 pseudouridine synthase FOB88_RS12480 ENOG4105WP7 tRNA pseudouridine synthase C FOB88_RS12485 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FOB88_RS12490 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOB88_RS12495 ENOG4105EWT decarboxylase family FOB88_RS12500 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FOB88_RS12505 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FOB88_RS12510 ENOG4105M08 Membrane FOB88_RS12515 ENOG4105ETT transcriptional Regulator, LysR family FOB88_RS12520 ENOG4105M5B (LipO)protein FOB88_RS12525 ENOG4105C9B Cysteine desulfurase FOB88_RS12530 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FOB88_RS12535 ENOG4105CUZ uba thif-type nad fad binding protein FOB88_RS12540 ENOG4105CA3 membrane-bound lytic murein transglycosylase FOB88_RS12560 ENOG4105BZC d-serine deaminase FOB88_RS12565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOB88_RS12570 ENOG4107QZM n-acetylglutamate synthase FOB88_RS12575 ENOG4107QYX exodeoxyribonuclease v alpha FOB88_RS12580 ENOG4107QKA exodeoxyribonuclease V beta FOB88_RS12585 ENOG4107QXK peptidase FOB88_RS12590 ENOG4105DSY exodeoxyribonuclease V, gamma FOB88_RS12605 ENOG4105JCS prepilin peptidase dependent protein FOB88_RS12610 ENOG4105IPU prepilin peptidase dependent protein A FOB88_RS12615 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOB88_RS12620 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FOB88_RS12625 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FOB88_RS12630 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOB88_RS12635 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FOB88_RS12640 ENOG4105EE5 Membrane protein terC FOB88_RS12645 ENOG4105SUV lipoprotein YgdR FOB88_RS12650 ENOG4105CPC Aldo Keto reductase FOB88_RS12660 ENOG4105RQF LysR family Transcriptional regulator FOB88_RS12665 ENOG4105F27 Major Facilitator FOB88_RS12680 ENOG4105CRK lysyL-tRNA synthetase FOB88_RS12690 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOB88_RS12695 ENOG4105T95 Thiol disulfide interChange protein FOB88_RS12700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOB88_RS12705 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FOB88_RS12715 ENOG4105Y75 tpr repeat protein FOB88_RS12725 ENOG4108UT2 hemolysin iii FOB88_RS12730 ENOG4108Q3X Transcriptional regulator FOB88_RS12735 ENOG4105CS2 ec 3.2.1.21 FOB88_RS12740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOB88_RS12745 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOB88_RS12750 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOB88_RS12755 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOB88_RS12760 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOB88_RS12765 ENOG4105D0A hydroxylase FOB88_RS12770 ENOG4107RAQ aminopeptidase FOB88_RS12780 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FOB88_RS12790 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOB88_RS12795 ENOG4108JQ1 Dehydrogenase FOB88_RS12805 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOB88_RS12810 ENOG4105MPN Membrane FOB88_RS12820 ENOG4105D64 Mechanosensitive ion channel FOB88_RS12830 ENOG4105D2N Aldolase FOB88_RS12835 ENOG4105BZA Phosphoglycerate kinase FOB88_RS12845 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOB88_RS12850 ENOG4108K0D peptidase, M48 FOB88_RS12860 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FOB88_RS12870 ENOG4107QNK )-transporter FOB88_RS12875 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS12880 ENOG4105GPY SprT protein FOB88_RS12885 ENOG4105RWS endonuclease I FOB88_RS12890 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOB88_RS12895 ENOG4105D7Z glutathione synthase FOB88_RS12900 ENOG4108UJU UPF0301 protein FOB88_RS12910 ENOG4105CZX twitching motility protein FOB88_RS12915 ENOG4105DFA alanine racemase domain protein FOB88_RS12920 ENOG4108VIA integral membrane protein FOB88_RS12925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOB88_RS12930 ENOG4105CSA Coproporphyrinogen iii oxidase FOB88_RS12935 ENOG4105FDP GntR family transcriptional regulator FOB88_RS12940 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FOB88_RS12955 ENOG4105K33 Periplasmic Protein FOB88_RS12960 ENOG41090ED Protein with unknown function (DUF469) FOB88_RS12965 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOB88_RS12970 ENOG4108K2B transcriptional regulator FOB88_RS12975 ENOG4105F8D glycoside hydrolase family 4 FOB88_RS12980 ENOG4105CT4 transporter FOB88_RS12985 ENOG4105CEN a g-specific adenine glycosylase FOB88_RS12990 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FOB88_RS12995 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FOB88_RS13000 ENOG4105CXN decarboxylase FOB88_RS13005 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FOB88_RS13015 ENOG4105NTW Transcriptional regulator FOB88_RS13020 ENOG4105Q26 Siderophore-interacting protein FOB88_RS13030 ENOG4105UEI Transcriptional Regulator AraC Family FOB88_RS13040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOB88_RS13045 ENOG4105C4M (Ubiquinol oxidase) subunit I FOB88_RS13050 ENOG4105KVH Transcriptional regulator FOB88_RS13055 ENOG4105ECR NmrA family FOB88_RS13070 ENOG4108ZHR arsR family transcriptional regulator FOB88_RS13085 ENOG4108N8X transition metal ion binding FOB88_RS13090 ENOG4108Z9Z response to DNA damage stimulus FOB88_RS13095 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FOB88_RS13105 ENOG410620I Diguanylate cyclase FOB88_RS13115 ENOG4108V08 YfdX protein FOB88_RS13120 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS13130 ENOG4107SDU Methyl-accepting chemotaxis FOB88_RS13140 ENOG4107SDU Methyl-accepting chemotaxis FOB88_RS13160 ENOG4107QNK )-transporter FOB88_RS13180 ENOG4108594 Permease of the drug metabolite transporter FOB88_RS13200 ENOG4105BZU Histidine kinase FOB88_RS13220 ENOG4105CW0 outer membrane usher protein FOB88_RS13225 ENOG4108AF8 Chaperone FOB88_RS13255 ENOG4105CDU Replicative dna helicase FOB88_RS13290 ENOG4105CVG Homoserine O-transsuccinylase FOB88_RS13305 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOB88_RS13310 ENOG4105C8T Leucyl-tRNA synthetase FOB88_RS13325 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOB88_RS13335 ENOG4105DVA methyltransferase FOB88_RS13340 ENOG4105C5S asparaginyl-tRNA synthetase FOB88_RS13350 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOB88_RS13360 ENOG4108UUM single-stranded DNA-binding protein FOB88_RS13410 ENOG4107QHF type ii secretion system protein e FOB88_RS13425 ENOG4105K5T PilT protein FOB88_RS13585 ENOG4105CQR helicase FOB88_RS13670 ENOG4105F5W AtP-binding protein FOB88_RS13700 ENOG4105MPK DNA polymerase III subunit theta FOB88_RS13785 ENOG4105BZU Histidine kinase FOB88_RS13795 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOB88_RS13800 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FOB88_RS13805 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOB88_RS13815 ENOG4105EYA deoxyribonuclease FOB88_RS13820 ENOG4108NRW Phospholipase, patatin family FOB88_RS13830 ENOG4105K3G Periplasmic Protein FOB88_RS13835 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOB88_RS13845 ENOG41090A1 ferritin FOB88_RS13855 ENOG4105DPW Major facilitator superfamily MFS_1 FOB88_RS13860 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS13865 ENOG4105E8R UPF0173 metal-dependent hydrolase FOB88_RS13880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS13890 ENOG4105Q95 Cupin 2, conserved barrel domain protein FOB88_RS13895 ENOG4105GSJ Inner membrane protein ylaC FOB88_RS13900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB88_RS13905 ENOG4105BZU Histidine kinase FOB88_RS13935 ENOG4105CSH Transporter FOB88_RS13940 ENOG4108ZZF transport protein (ExbD) FOB88_RS13945 ENOG4105CWK Biopolymer transport protein, ExbB FOB88_RS13950 ENOG4105CI1 PTS System FOB88_RS13955 ENOG4107P2S Transcriptional regulator FOB88_RS13965 ENOG4105D2S major facilitator superfamily FOB88_RS13970 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOB88_RS13975 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FOB88_RS13980 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FOB88_RS13985 ENOG4105DDW LysR family Transcriptional regulator FOB88_RS13990 ENOG4105F2Z 3-oxoadipate enol-lactonase FOB88_RS13995 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FOB88_RS14000 ENOG4105CHU acetyl-coa acetyltransferase FOB88_RS14005 ENOG4107QNJ CoA-transferase subunit B FOB88_RS14010 ENOG4107QP7 CoA-transferase subunit A FOB88_RS14015 ENOG4107HP6 Transcriptional regulator FOB88_RS14020 ENOG4105C28 cystathionine FOB88_RS14025 ENOG4108K81 inner membrane protein YghB FOB88_RS14030 ENOG4105CF7 AraC family transcriptional regulator FOB88_RS14035 ENOG4105CV8 reductase FOB88_RS14040 ENOG4105I03 Flagellin FOB88_RS14045 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FOB88_RS14050 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FOB88_RS14055 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB88_RS14060 ENOG4105ETD TRANSCRIPTIONal FOB88_RS14065 ENOG4105DM4 PTS System FOB88_RS14070 ENOG4105DM4 PTS System FOB88_RS14075 ENOG4105DM4 PTS System FOB88_RS14085 ENOG4105D2N Aldolase FOB88_RS14090 ENOG4105F87 Dehydratase FOB88_RS14095 ENOG4105NF4 modulator of drug activity FOB88_RS14100 ENOG4105VRH Antibiotic biosynthesis monooxygenase FOB88_RS14105 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB88_RS14110 ENOG4105IPS esterase FOB88_RS14115 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOB88_RS14120 ENOG4108SX3 cytoplasmic protein FOB88_RS14125 ENOG41087AY ADP-Ribose pyrophosphatase FOB88_RS14130 ENOG4105DFG type I secretion outer membrane protein FOB88_RS14135 ENOG4105F1G UPF0441 protein FOB88_RS14140 ENOG4106032 Glutathionylspermidine synthase FOB88_RS14145 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOB88_RS14150 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOB88_RS14155 ENOG4105W0Z cytoplasmic protein FOB88_RS14165 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FOB88_RS14170 ENOG4105I7R Adenylate cyclase FOB88_RS14175 ENOG4106MWK domain protein FOB88_RS14180 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOB88_RS14185 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOB88_RS14190 ENOG4107ZVW dihydroneopterin aldolase FOB88_RS14200 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOB88_RS14210 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOB88_RS14215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB88_RS14255 ENOG4105ZTC transcriptional activator, Ogr delta FOB88_RS14295 ENOG4108C33 Resolvase FOB88_RS14390 ENOG4105VZ1 Replication Protein FOB88_RS14395 ENOG4105KSC Transcriptional regulator, TraR DksA family FOB88_RS14415 ENOG4105D2N Aldolase FOB88_RS14420 ENOG4105DM4 PTS System FOB88_RS14425 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOB88_RS14430 ENOG4105ETD TRANSCRIPTIONal FOB88_RS14435 ENOG4105CHH sulfate transporter FOB88_RS14440 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS14445 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS14485 ENOG4105BZU Histidine kinase FOB88_RS14495 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS14500 ENOG4105BZU Histidine kinase FOB88_RS14505 ENOG4105BZU Histidine kinase FOB88_RS14515 ENOG4105CPF Cell wall formation (By similarity) FOB88_RS14520 ENOG4105BZU Histidine kinase FOB88_RS14525 ENOG4105CHH sulfate transporter FOB88_RS14530 ENOG41077A9 carbonic anhydrase FOB88_RS14535 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOB88_RS14545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB88_RS14550 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FOB88_RS14555 ENOG4108VKG metal-dependent hydrolase FOB88_RS14565 ENOG4105EE0 oxidoreductase FOB88_RS14570 ENOG4105DU1 integral membrane protein, terc FOB88_RS14575 ENOG4105CTX dehydratase FOB88_RS14585 ENOG4105D2H Uronic isomerase FOB88_RS14590 ENOG4105DPW Major facilitator superfamily MFS_1 FOB88_RS14600 ENOG4106W5V Membrane FOB88_RS14610 ENOG4105WAY exported protein FOB88_RS14615 ENOG4105NE1 Conserved Protein FOB88_RS14620 ENOG41090KG Inner membrane protein YqjE FOB88_RS14625 ENOG4105YJD FOB88_RS14630 ENOG4108VBZ doxx family FOB88_RS14650 ENOG4105CHF Glutathione S-transferase FOB88_RS14655 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) FOB88_RS14660 ENOG4105C7B Threonine dehydratase FOB88_RS14675 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOB88_RS14680 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FOB88_RS14685 ENOG41082RQ UPF0102 protein FOB88_RS14695 ENOG4105W4M Transport-associated protein FOB88_RS14700 ENOG4108CNN domain protein FOB88_RS14705 ENOG4105CWB LysR family transcriptional Regulator FOB88_RS14710 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FOB88_RS14725 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOB88_RS14755 ENOG4105E98 transcriptional regulator DeoR family FOB88_RS14760 ENOG4108XVM Cytochrome b(562) FOB88_RS14765 ENOG4105CMS peptidase U62, modulator of DNA gyrase FOB88_RS14770 ENOG4105N42 UPF0307 protein FOB88_RS14775 ENOG4105DFU Cell wall formation (By similarity) FOB88_RS14780 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FOB88_RS14785 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS14795 ENOG4108VMM UPF0756 membrane protein FOB88_RS14800 ENOG4105F0N pyrophosphate phospho-hydrolase FOB88_RS14810 ENOG4108ZHD aig2 family FOB88_RS14815 ENOG4105MA0 exported protein FOB88_RS14820 ENOG4105CFU surface antigen FOB88_RS14830 ENOG4105C37 (CBS) domain FOB88_RS14835 ENOG41061GZ Protein of unknown function (DUF1107) FOB88_RS14840 ENOG4108UUE Transcriptional regulator FOB88_RS14845 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FOB88_RS14850 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOB88_RS14855 ENOG4108V1T peptidylprolyl cis-trans isomerase FOB88_RS14860 ENOG4105FHY Opacity-associated protein A FOB88_RS14870 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOB88_RS14875 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOB88_RS14880 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FOB88_RS14885 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOB88_RS14890 ENOG4108MXZ Esterase FOB88_RS14895 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS14900 ENOG4105WSB biofilm stress and motility protein A FOB88_RS14905 ENOG4105CSU acyl-Coa dehydrogenase FOB88_RS14910 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOB88_RS14915 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOB88_RS14925 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOB88_RS14935 ENOG4105EPW hflc protein FOB88_RS14940 ENOG4107QJR hflk protein FOB88_RS14945 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOB88_RS14955 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOB88_RS14960 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOB88_RS14965 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOB88_RS14970 ENOG4105K8N protein family UPF0079, ATPase FOB88_RS14975 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOB88_RS14980 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOB88_RS15000 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FOB88_RS15005 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOB88_RS15010 ENOG4105DJ4 phosphatidylserine decarboxylase FOB88_RS15015 ENOG4105EGS Mechanosensitive ion channel FOB88_RS15020 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOB88_RS15025 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FOB88_RS15030 ENOG4105RID UPF0379 protein yhcN FOB88_RS15040 ENOG4105RID UPF0379 protein yhcN FOB88_RS15050 ENOG4105UNR (Barnase) inhibitor FOB88_RS15055 ENOG4105C26 Dehydrogenase FOB88_RS15060 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) FOB88_RS15065 ENOG4105Y49 secretion protein, HlyD family FOB88_RS15070 ENOG4105ZQC membrane protein AaeX FOB88_RS15075 ENOG4105CR8 Transcriptional regulator FOB88_RS15080 ENOG4105D1U peptidase U62 modulator of DNA gyrase FOB88_RS15085 ENOG4105QD6 exported protein FOB88_RS15090 ENOG4105C03 ribonuclease FOB88_RS15100 ENOG4105VQ7 Rod shape-determining protein MreD FOB88_RS15105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOB88_RS15115 ENOG41062P1 Diguanylate cyclase phosphodiesterase FOB88_RS15120 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOB88_RS15125 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FOB88_RS15130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOB88_RS15135 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOB88_RS15140 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOB88_RS15145 ENOG4105RG0 Membrane FOB88_RS15150 ENOG4108IA2 Sodium pantothenate symporter FOB88_RS15155 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOB88_RS15165 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FOB88_RS15175 ENOG4105EZ7 amino acid ABC transporter FOB88_RS15180 ENOG4105DRP amino acid AbC transporter FOB88_RS15185 ENOG4105CDA abc transporter atp-binding protein FOB88_RS15220 ENOG4108Z0R Transferase FOB88_RS15225 ENOG4105SG3 Protein of unknown function (DUF1488) FOB88_RS15230 ENOG4105E2X shikimate dehydrogenase FOB88_RS15240 ENOG4108WI1 Dna topoisomerase FOB88_RS15250 ENOG4105C79 DNA protecting protein DprA FOB88_RS15260 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOB88_RS15265 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOB88_RS15270 ENOG4105C1A potassium transporter peripheral membrane FOB88_RS15275 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FOB88_RS15285 ENOG4105VTS DnaJ-like, subfamily C FOB88_RS15290 ENOG4108ZT0 50S ribosomal protein l17 FOB88_RS15295 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB88_RS15300 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOB88_RS15305 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOB88_RS15310 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOB88_RS15315 ENOG41067V7 50S ribosomal protein L36 FOB88_RS15320 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOB88_RS15325 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOB88_RS15330 ENOG4105VPB 50S ribosomal protein L30 FOB88_RS15335 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOB88_RS15340 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOB88_RS15345 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOB88_RS15355 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOB88_RS15365 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOB88_RS15370 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOB88_RS15380 ENOG41083MP 50s ribosomal protein l29 FOB88_RS15385 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOB88_RS15390 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOB88_RS15395 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOB88_RS15400 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOB88_RS15405 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOB88_RS15415 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOB88_RS15435 ENOG4108UQY Iron-storage protein FOB88_RS15440 ENOG4105W53 bacterioferritin-associated ferredoxin FOB88_RS15445 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOB88_RS15450 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOB88_RS15455 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOB88_RS15460 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOB88_RS15470 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FOB88_RS15475 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FOB88_RS15480 ENOG4105WWK YheO domain protein FOB88_RS15485 ENOG4108V1T peptidylprolyl cis-trans isomerase FOB88_RS15490 ENOG4105VRX Protein slyX homolog FOB88_RS15495 ENOG4108YZY peptidylprolyl cis-trans isomerase FOB88_RS15500 ENOG4105VKU nucleicacid-binding protein FOB88_RS15505 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOB88_RS15510 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOB88_RS15515 ENOG4105C5H ABC transporter FOB88_RS15520 ENOG4105E2B Taurine dioxygenase FOB88_RS15525 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOB88_RS15530 ENOG4108ETV ABC transporter FOB88_RS15535 ENOG4106FTQ Taurine ABC transporter, periplasmic FOB88_RS15540 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS15550 ENOG4105DNZ Alpha Beta Hydrolase FOB88_RS15555 ENOG4105YP7 UPF0270 protein FOB88_RS15560 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FOB88_RS15565 ENOG4108UKZ OsmC family FOB88_RS15570 ENOG4107RYR Transcriptional regulator, Crp Fnr family FOB88_RS15575 ENOG410613R integral membrane protein, YccS YhfK family FOB88_RS15580 ENOG4105C8Y Acetylornithine aminotransferase FOB88_RS15590 ENOG4105MZU cell filamentation protein FOB88_RS15600 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FOB88_RS15605 ENOG4106DTQ Protein TsgA homolog FOB88_RS15610 ENOG4105DZC cytosine deaminase FOB88_RS15615 ENOG4105C31 Tryptophanyl-tRNA synthetase FOB88_RS15620 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOB88_RS15625 ENOG4105DJV ribulose-phosphate 3-epimerase FOB88_RS15635 ENOG4105EGB membrane protein DamX FOB88_RS15640 ENOG4105D49 3-dehydroquinate synthase FOB88_RS15645 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOB88_RS15650 ENOG4105E4G Type IV pilus FOB88_RS15675 ENOG4108JQC penicillin-binding protein 1A FOB88_RS15680 ENOG4107RK2 ADP-ribose diphosphatase NudE FOB88_RS15685 ENOG4105DQY intracellular growth attenuator FOB88_RS15690 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FOB88_RS15695 ENOG4105VEJ Heat shock protein FOB88_RS15700 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOB88_RS15705 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FOB88_RS15710 ENOG4105E0F Histidine kinase FOB88_RS15725 ENOG4108RRZ Transcription elongation factor GreB FOB88_RS15730 ENOG4105BZM domain protein FOB88_RS15735 ENOG4107QW3 Sucrose phosphorylase FOB88_RS15745 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOB88_RS15750 ENOG4105MJ2 Competence protein FOB88_RS15755 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FOB88_RS15760 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FOB88_RS15765 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOB88_RS15770 ENOG4105E98 transcriptional regulator DeoR family FOB88_RS15780 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOB88_RS15785 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOB88_RS15790 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOB88_RS15795 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOB88_RS15800 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOB88_RS15805 ENOG4108IUM Glycogen debranching enzyme FOB88_RS15815 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOB88_RS15820 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FOB88_RS15825 ENOG4105C6Z Gluconate FOB88_RS15830 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FOB88_RS15835 ENOG4105DIQ Transcriptional regulator FOB88_RS15840 ENOG4105C2I pirin domain protein FOB88_RS15845 ENOG4105WCN acetyltransferase FOB88_RS15850 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOB88_RS15860 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FOB88_RS15875 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOB88_RS15880 ENOG4105BZ7 extracellular solute-binding protein family 1 FOB88_RS15885 ENOG4108IV0 ABC, transporter FOB88_RS15890 ENOG4105C0Z ABC transporter FOB88_RS15895 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOB88_RS15900 ENOG4105C32 Amino acid ABC transporter (Permease) FOB88_RS15905 ENOG4105CP9 extracellular ligand-binding receptor FOB88_RS15910 ENOG4105U59 -acetyltransferase FOB88_RS15915 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB88_RS15920 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOB88_RS15925 ENOG4105CAK Cell division ATP-binding protein ftsE FOB88_RS15930 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOB88_RS15930 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOB88_RS15935 ENOG4106H78 methyltransferase FOB88_RS15940 ENOG4105MG3 Membrane FOB88_RS15950 ENOG4107FS9 Membrane FOB88_RS15960 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FOB88_RS15965 ENOG4105EX9 Membrane FOB88_RS15970 ENOG4108W1V Lipoprotein FOB88_RS15980 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FOB88_RS15985 ENOG4107RJ5 oxidoreductase FOB88_RS15990 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOB88_RS16000 ENOG4105DH8 myo-inositol catabolism FOB88_RS16005 ENOG4105C26 Dehydrogenase FOB88_RS16010 ENOG4105C2W permease FOB88_RS16015 ENOG4105DSF transport protein FOB88_RS16020 ENOG4105C6F GntR Family Transcriptional Regulator FOB88_RS16025 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FOB88_RS16030 ENOG4105CXC rtn protein FOB88_RS16040 ENOG4105CSH Transporter FOB88_RS16045 ENOG4105D52 delta-aminolevulinic acid dehydratase FOB88_RS16055 ENOG4105WPN DNA integration recombination invertion protein FOB88_RS16060 ENOG4105CHR reductase FOB88_RS16080 ENOG4108UQS dipeptidase FOB88_RS16085 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB88_RS16090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS16095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS16100 ENOG4105C3U ABC transporter FOB88_RS16105 ENOG4107H6U ABC transporter FOB88_RS16115 ENOG4105CBX hi0933 family FOB88_RS16120 ENOG4105CJ3 phosphate transporter FOB88_RS16125 ENOG4108V6B universal stress protein B FOB88_RS16130 ENOG4108M6U Universal stress protein A FOB88_RS16135 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FOB88_RS16140 ENOG4105DGW oligopeptidase A FOB88_RS16145 ENOG4105D6S protein involved in catabolism of external DNA FOB88_RS16155 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOB88_RS16160 ENOG4105DC8 reductase FOB88_RS16170 ENOG4105ECY inositol monophosphatase FOB88_RS16175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS16195 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FOB88_RS16220 ENOG4105EQ0 Major Facilitator superfamily FOB88_RS16225 ENOG4105HEI LysR family (Transcriptional regulator FOB88_RS16230 ENOG4108TEB UPF0114 protein FOB88_RS16235 ENOG4105C08 Histidine kinase FOB88_RS16240 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FOB88_RS16245 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOB88_RS16250 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOB88_RS16260 ENOG4105CPI Metal Dependent Phosphohydrolase FOB88_RS16270 ENOG4105BZ1 (ABC) transporter FOB88_RS16280 ENOG4106KED esterase YpfH FOB88_RS16285 ENOG41082CG Protein CrcB homolog FOB88_RS16300 ENOG4105CPQ Dehydrogenase FOB88_RS16305 ENOG410617M Transcriptional regulator FOB88_RS16310 ENOG4108I5G Major Facilitator superfamily FOB88_RS16325 ENOG4105ERH Fumarylacetoacetate hydrolase FOB88_RS16335 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) FOB88_RS16340 ENOG4105WQ6 Membrane FOB88_RS16355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB88_RS16360 ENOG4108TGY Glutathione S-transferase FOB88_RS16365 ENOG4105JAB phenazine biosynthesis protein, phzf family FOB88_RS16370 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOB88_RS16375 ENOG4105CBN LysR family transcriptional regulator FOB88_RS16380 ENOG4107H3J ribonuclease FOB88_RS16385 ENOG4105CSH Transporter FOB88_RS16390 ENOG4105CC0 LysR family Transcriptional regulator FOB88_RS16395 ENOG4107QXX ABC transporter FOB88_RS16415 ENOG4105CPF Cell wall formation (By similarity) FOB88_RS16430 ENOG4105EMY transcriptional regulator FOB88_RS16435 ENOG4105C7B Threonine dehydratase FOB88_RS16440 ENOG4105C01 Dihydroxy-acid dehydratase FOB88_RS16445 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOB88_RS16450 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FOB88_RS16465 ENOG4105C0P Mg chelatase subunit ChlI FOB88_RS16470 ENOG4108WFC UPF0438 protein yifE FOB88_RS16475 ENOG4105CVI Transcriptional regulator FOB88_RS16520 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FOB88_RS16525 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FOB88_RS16530 ENOG4108Y73 Membrane FOB88_RS16540 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOB88_RS16545 ENOG4105C5Q Transcriptional regulator FOB88_RS16550 ENOG4105CH7 arginosuccinase FOB88_RS16555 ENOG4105CDH Citrulline--aspartate ligase FOB88_RS16560 ENOG4105CAS nag kinase FOB88_RS16570 ENOG4105CWC Acetylornithine deacetylase FOB88_RS16575 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOB88_RS16580 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS16585 ENOG4105SYT Methylenetetrahydrofolate reductase FOB88_RS16590 ENOG4105CFH Aspartokinase FOB88_RS16595 ENOG4105C28 cystathionine FOB88_RS16600 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FOB88_RS16605 ENOG4105VFB Binds the 23S rRNA (By similarity) FOB88_RS16610 ENOG4105C25 Primosomal protein n' FOB88_RS16615 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS16620 ENOG41063M6 Cell Division Protein FOB88_RS16625 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOB88_RS16630 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOB88_RS16635 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FOB88_RS16640 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FOB88_RS16645 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOB88_RS16650 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOB88_RS16655 ENOG4105CBT Fructose-1,6-bisphosphatase FOB88_RS16660 ENOG4105E5M Multidrug resistance protein D FOB88_RS16665 ENOG4105DP0 ferredoxin-NADP reductase FOB88_RS16670 ENOG4108VTS Membrane FOB88_RS16675 ENOG4105EBK exported protein FOB88_RS16680 ENOG4105CP7 Triose-phosphate isomerase FOB88_RS16690 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOB88_RS16695 ENOG4105CTQ phosphohexokinase FOB88_RS16700 ENOG41076HS cation diffusion facilitator family transporter FOB88_RS16710 ENOG4105FMW periplasmic FOB88_RS16715 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB88_RS16720 ENOG4105E0F Histidine kinase FOB88_RS16725 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOB88_RS16730 ENOG4105D7W serine acetyltransferase FOB88_RS16735 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOB88_RS16740 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FOB88_RS16745 ENOG4105VW4 glutaredoxin 3 FOB88_RS16750 ENOG4107YZP Rhodanese domain protein FOB88_RS16755 ENOG41063SB peptidase FOB88_RS16760 ENOG4105PXI polysaccharide deacetylase FOB88_RS16770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOB88_RS16775 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOB88_RS16780 ENOG4105XA0 heptosyltransferase ii FOB88_RS16785 ENOG4105D16 lipopolysaccharide heptosyltransferase i FOB88_RS16790 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) FOB88_RS16795 ENOG41068PG O-Antigen polymerase FOB88_RS16810 ENOG4105CPK Glycosyl transferase (Group 1 FOB88_RS16820 ENOG4105K64 Glycosyl transferase, family 2 FOB88_RS16825 ENOG4105DKP glycosyl transferase, family 9 FOB88_RS16835 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FOB88_RS16840 ENOG4106WTF Glycosyl transferase, family 2 FOB88_RS16845 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOB88_RS16850 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOB88_RS16860 ENOG4105KDC 50s ribosomal protein l28 FOB88_RS16865 ENOG4105W5Q DNA repair protein (RadC FOB88_RS16870 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOB88_RS16875 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOB88_RS16880 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOB88_RS16885 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOB88_RS16890 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOB88_RS16895 ENOG4105D9N nucleoside FOB88_RS16905 ENOG4105DSJ YicC domain protein FOB88_RS16925 ENOG4105D1S lipid A biosynthesis FOB88_RS16930 ENOG4105PSV Polysaccharide Biosynthesis Protein FOB88_RS16935 ENOG4105EN6 Membrane FOB88_RS16940 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FOB88_RS16950 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOB88_RS16955 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOB88_RS16960 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FOB88_RS16965 ENOG4105CB5 ATP-dependent DNA helicase recG FOB88_RS16970 ENOG4105C2W permease FOB88_RS16975 ENOG4105JV1 AsmA family FOB88_RS16980 ENOG4105SUU thioesterase domain FOB88_RS16990 ENOG4107S2Z UPF0761 membrane protein FOB88_RS16995 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FOB88_RS17000 ENOG4105CI3 gtp-binding protein typa FOB88_RS17005 ENOG4105C5F glutamine synthetase FOB88_RS17010 ENOG4105CUX Signal transduction histidine kinase FOB88_RS17015 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB88_RS17020 ENOG4105D4P Coproporphyrinogen iii oxidase FOB88_RS17025 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FOB88_RS17035 ENOG4105C2M dna polymerase I FOB88_RS17040 ENOG4108Z33 Thiol disulfide Interchange Protein FOB88_RS17045 ENOG4105E27 serine threonine protein kinase FOB88_RS17050 ENOG4105PC1 Conserved Protein FOB88_RS17055 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FOB88_RS17060 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FOB88_RS17085 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS17090 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS17095 ENOG4108RVA ribokinase FOB88_RS17100 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOB88_RS17105 ENOG4105CNN ABC, transporter FOB88_RS17110 ENOG4105C2J ABC transporter FOB88_RS17120 ENOG4105H4F exported protein FOB88_RS17125 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOB88_RS17130 ENOG4105DHQ Histidine kinase FOB88_RS17135 ENOG4105DFH Transport of potassium into the cell (By similarity) FOB88_RS17145 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FOB88_RS17150 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process FOB88_RS17155 ENOG4108VVK transcriptional Regulator, AsnC FOB88_RS17160 ENOG4105QTB Flavodoxin FOB88_RS17170 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOB88_RS17175 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FOB88_RS17180 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FOB88_RS17185 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB88_RS17190 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB88_RS17195 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB88_RS17200 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOB88_RS17205 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOB88_RS17210 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOB88_RS17215 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOB88_RS17220 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOB88_RS17225 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOB88_RS17235 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FOB88_RS17240 ENOG4105C8U phosphate abc transporter FOB88_RS17245 ENOG4105E2Z phosphate ABC transporter (Permease FOB88_RS17250 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS17260 ENOG4107RGD Major Facilitator superfamily FOB88_RS17265 ENOG4105CMG Carbohydrate kinase FOB88_RS17270 ENOG4105C93 Xylose Isomerase FOB88_RS17275 ENOG4105DFW ABC transporter FOB88_RS17285 ENOG4108HWW ABC transporter FOB88_RS17290 ENOG4105T16 Transcriptional regulator (AraC family) FOB88_RS17310 ENOG4105C2J ABC transporter FOB88_RS17315 ENOG4105CNN ABC, transporter FOB88_RS17320 ENOG4105CNN ABC, transporter FOB88_RS17325 ENOG4105NYY transcriptional regulator, RpiR FOB88_RS17355 ENOG4107SDU Methyl-accepting chemotaxis FOB88_RS17360 ENOG4105F04 LysR family Transcriptional regulator FOB88_RS17370 ENOG4105CSH Transporter FOB88_RS17375 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FOB88_RS17380 ENOG4105VCP PTS System FOB88_RS17385 ENOG4105CS2 ec 3.2.1.21 FOB88_RS17390 ENOG4105CK1 PTS System FOB88_RS17395 ENOG4105VZJ PTS System FOB88_RS17400 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS17405 ENOG4105E2R ROK family FOB88_RS17410 ENOG4106CVF DNA replication protein FOB88_RS17415 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) FOB88_RS17425 ENOG4108R3E Dna-3-methyladenine glycosylase i FOB88_RS17430 ENOG4108ZG0 Ompa motb domain protein FOB88_RS17440 ENOG4108M60 Transcriptional regulator FOB88_RS17450 ENOG4105D7K pfkb domain protein FOB88_RS17460 ENOG4105C5I Dehydrogenase FOB88_RS17465 ENOG4105JKW Valine--pyruvate aminotransferase FOB88_RS17470 ENOG4108594 Permease of the drug metabolite transporter FOB88_RS17475 ENOG4105GAK amidohydrolase 2 FOB88_RS17485 ENOG4108ZNX Heat shock protein FOB88_RS17490 ENOG4105R2A (LipO)protein FOB88_RS17495 ENOG4105D99 atp gtp-binding protein FOB88_RS17500 ENOG410667J hydrolase FOB88_RS17505 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB88_RS17510 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOB88_RS17515 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOB88_RS17520 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOB88_RS17525 ENOG4105VG0 50S ribosomal protein l34 FOB88_RS17530 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOB88_RS17540 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOB88_RS17545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOB88_RS17550 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FOB88_RS17560 ENOG4105C7N Xanthine uracil vitamin C permease FOB88_RS17565 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FOB88_RS17570 ENOG4105MEV Acyl-transferase FOB88_RS17575 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOB88_RS17580 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOB88_RS17590 ENOG4105H38 Membrane FOB88_RS17595 ENOG4108U78 Glutathione S-transferase FOB88_RS17600 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FOB88_RS17610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOB88_RS17615 ENOG4108MJ5 VirK protein FOB88_RS17620 ENOG4108YYI Protein of unknown function (DUF2810) FOB88_RS17625 ENOG4105E61 Mannitol repressor protein FOB88_RS17635 ENOG4105CTS PTS system mannitol-specific FOB88_RS17640 ENOG4106JH6 (LipO)protein FOB88_RS17645 ENOG4105MVF Transcriptional regulator FOB88_RS17650 ENOG4108P6C Tryptophan transporter of low affinity FOB88_RS17670 ENOG4105K56 Transcriptional regulator FOB88_RS17675 ENOG4108ZHJ Organic hydroperoxide resistance protein FOB88_RS17680 ENOG4105DIJ Phosphoethanolamine transferase FOB88_RS17700 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB88_RS17705 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS17710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS17715 ENOG4105C3U ABC transporter FOB88_RS17720 ENOG4108JQ7 (ABC) transporter FOB88_RS17730 ENOG4107R21 site-determining protein FOB88_RS17735 ENOG4107QZ7 Cellulose synthase catalytic subunit FOB88_RS17740 ENOG4107EEX Cellulose synthase regulator protein FOB88_RS17755 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FOB88_RS17760 ENOG4105BZU Histidine kinase FOB88_RS17765 ENOG4105CK2 sodium dicarboxylate symporter FOB88_RS17770 ENOG4105CS0 peptidase FOB88_RS17785 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FOB88_RS17790 ENOG4105CMB EAL domain-containing protein FOB88_RS17795 ENOG41066T0 asmA family FOB88_RS17800 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FOB88_RS17805 ENOG4105C4R Atp-dependent dna helicase FOB88_RS17810 ENOG4105C9X ppx gppa phosphatase FOB88_RS17815 ENOG4105C1J atp-dependent rna helicase FOB88_RS17825 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOB88_RS17830 ENOG4105ESV Glycosyl transferase, family 4 FOB88_RS17835 ENOG4105SFE lipopolysaccharide biosynthesis protein FOB88_RS17840 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOB88_RS17845 ENOG4108IJ1 Dehydrogenase FOB88_RS17850 ENOG4108WJ1 acetyltransferase FOB88_RS17855 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOB88_RS17860 ENOG4105EGZ biosynthesis protein FOB88_RS17870 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FOB88_RS17875 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FOB88_RS17910 ENOG410601J HemY protein FOB88_RS17915 ENOG4105ECF c-methyltransferase FOB88_RS17920 ENOG41076E6 Uroporphyrinogen-III Synthase FOB88_RS17925 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOB88_RS17930 ENOG4107T0K Adenylate cyclase FOB88_RS17935 ENOG4105S7Z (LipO)protein FOB88_RS17940 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOB88_RS17945 ENOG4105CT0 Protein of unknown function, DUF484 FOB88_RS17955 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FOB88_RS17960 ENOG4105C4R Atp-dependent dna helicase FOB88_RS17970 ENOG4108KK1 membrane protein AbrB duplication FOB88_RS17975 ENOG4105FR1 rard protein FOB88_RS17980 ENOG4105KVH Transcriptional regulator FOB88_RS17990 ENOG4108VUY thioesterase Superfamily protein FOB88_RS17995 ENOG4105HDD phospholipase FOB88_RS18000 ENOG4105C9U ATP-dependent DNA helicase RecQ FOB88_RS18005 ENOG4105CCF Lysine exporter protein (Lyse ygga) FOB88_RS18010 ENOG410829K Lysine exporter protein (Lyse ygga) FOB88_RS18015 ENOG4108EUD Lysophospholipase FOB88_RS18020 ENOG4105DQF Hydrolase FOB88_RS18025 ENOG4105CXY transporter FOB88_RS18030 ENOG4105EMK carboxylate amino acid amine transporter FOB88_RS18035 ENOG4108W15 Protein of unknown function (DUF1456) FOB88_RS18040 ENOG4105DZ2 Transcriptional regulator FOB88_RS18045 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOB88_RS18050 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOB88_RS18055 ENOG4108I5U Uridine phosphorylase FOB88_RS18060 ENOG4105CGY Dna recombination protein FOB88_RS18065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOB88_RS18070 ENOG4105JC1 sterol-binding domain protein FOB88_RS18075 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOB88_RS18080 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOB88_RS18085 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FOB88_RS18090 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOB88_RS18095 ENOG4105F8V Hydrolase, tatD family FOB88_RS18100 ENOG4105MDZ Transcriptional activator rfaH FOB88_RS18105 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOB88_RS18110 ENOG4108EX3 reductase FOB88_RS18115 ENOG4105CHU acetyl-coa acetyltransferase FOB88_RS18120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOB88_RS18125 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) FOB88_RS18130 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOB88_RS18135 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOB88_RS18140 ENOG4108RR8 protoporphyrinogen oxidase FOB88_RS18165 ENOG4105D4A Cell wall formation (By similarity) FOB88_RS18170 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FOB88_RS18175 ENOG4105CS9 pantothenic acid kinase FOB88_RS18200 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOB88_RS18205 ENOG4105PM1 preprotein translocase subunit SecE FOB88_RS18210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOB88_RS18215 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOB88_RS18220 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOB88_RS18225 ENOG4108VZM 50s ribosomal protein L10 FOB88_RS18230 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOB88_RS18235 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB88_RS18240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB88_RS18250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB88_RS18255 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOB88_RS18260 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FOB88_RS18265 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) FOB88_RS18270 ENOG4105E09 nadh pyrophosphatase FOB88_RS18275 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOB88_RS18285 ENOG4105R2J Conserved Protein FOB88_RS18295 ENOG4108T8B Protein of unknown function (DUF1481) FOB88_RS18300 ENOG4105C12 Phosphoribosylglycinamide synthetase FOB88_RS18305 ENOG4105DC1 bifunctional purine biosynthesis protein purh FOB88_RS18340 ENOG4105S10 periplasmic binding protein FOB88_RS18345 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein FOB88_RS18350 ENOG4105CVG Homoserine O-transsuccinylase FOB88_RS18355 ENOG4107QP3 malate synthase g FOB88_RS18360 ENOG4108I9X Isocitrate lyase FOB88_RS18365 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FOB88_RS18370 ENOG4105C6F GntR Family Transcriptional Regulator FOB88_RS18380 ENOG4105CT4 transporter FOB88_RS18385 ENOG4107S1E Beta-lactamase FOB88_RS18390 ENOG41069M3 Transcriptional regulator FOB88_RS18395 ENOG4105C3R Methionine synthase FOB88_RS18400 ENOG4105E3R (LipO)protein FOB88_RS18405 ENOG4108W78 Pfam:DUF1017 FOB88_RS18410 ENOG4108Y9B (LipO)protein FOB88_RS18425 ENOG4105CFH Aspartokinase FOB88_RS18430 ENOG4105C09 Bile acid FOB88_RS18435 ENOG4105EAM Na Pi-cotransporter FOB88_RS18445 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOB88_RS18450 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FOB88_RS18460 ENOG4105VNT transposase (IS4 family) protein FOB88_RS18470 ENOG41080IJ Diacylglycerol kinase FOB88_RS18475 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOB88_RS18480 ENOG4107R73 Mate efflux family protein FOB88_RS18485 ENOG4105VDW Csbd family FOB88_RS18490 ENOG4105MYN Zinc uptake regulation protein FOB88_RS18500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOB88_RS18505 ENOG4105P4Z Phage shock protein G FOB88_RS18510 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOB88_RS18515 ENOG4105CDU Replicative dna helicase FOB88_RS18520 ENOG4108XM1 transcriptional regulator AsnC family FOB88_RS18530 ENOG4105CGF Aromatic amino acid aminotransferase FOB88_RS18535 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FOB88_RS18540 ENOG4105MSB protein, conserved in bacteria FOB88_RS18545 ENOG4105DQ4 alcohol dehydrogenase FOB88_RS18555 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOB88_RS18560 ENOG4108UUM single-stranded DNA-binding protein FOB88_RS18595 ENOG4105PMV Membrane FOB88_RS18600 ENOG4108W3Q Transcriptional regulator FOB88_RS18605 ENOG4108Z4X TRANSCRIPTIONal FOB88_RS18615 ENOG4105C7N Xanthine uracil vitamin C permease FOB88_RS18620 ENOG4105EEQ Na H antiporter FOB88_RS18625 ENOG4105CMU LysR family (Transcriptional regulator FOB88_RS18630 ENOG4105VAW lrga family FOB88_RS18635 ENOG41067MG lrgb family FOB88_RS18645 ENOG4107QN1 sodium solute FOB88_RS18650 ENOG41062QD Membrane FOB88_RS18655 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOB88_RS18660 ENOG4105CK2 sodium dicarboxylate symporter FOB88_RS18665 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOB88_RS18670 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) FOB88_RS18675 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FOB88_RS18680 ENOG4105E7U AraC family transcriptional regulator FOB88_RS18695 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FOB88_RS18715 ENOG4107QNK )-transporter FOB88_RS18720 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS18730 ENOG4105DRB nucleoside-specific channel-forming protein FOB88_RS18735 ENOG4105DHQ Histidine kinase FOB88_RS18740 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOB88_RS18745 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FOB88_RS18750 ENOG4105JQN Transcriptional regulator FOB88_RS18755 ENOG4105C6X Major Facilitator FOB88_RS18760 ENOG4105DZG Dehydrogenase FOB88_RS18775 ENOG4105RD7 BadF BadG BcrA BcrD FOB88_RS18800 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOB88_RS18805 ENOG4105DRS transport system, permease FOB88_RS18815 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOB88_RS18820 ENOG4105W7K Transcriptional regulator FOB88_RS18825 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS18835 ENOG4105CYM Glutathione S-transferase FOB88_RS18840 ENOG4105D7K pfkb domain protein FOB88_RS18845 ENOG4105CNT hydrolase family 2 FOB88_RS18850 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FOB88_RS18855 ENOG4108M0B Sucrose porin FOB88_RS18860 ENOG4105C5Y PTS System FOB88_RS18870 ENOG4105WBN Transcriptional regulator (LacI family FOB88_RS18875 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FOB88_RS18890 ENOG4107QPB Beta-lactamase domain protein FOB88_RS18900 ENOG4105CEP NADH dehydrogenase FOB88_RS18910 ENOG4105PY6 Phenolic acid decarboxylase FOB88_RS18945 ENOG4105DUU IucA IucC family protein FOB88_RS18950 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FOB88_RS18960 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS18970 ENOG4105R3P Inner membrane protein yagU FOB88_RS18975 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FOB88_RS18980 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FOB88_RS18985 ENOG4105H6Q decarboxylase FOB88_RS18990 ENOG4105CMG Carbohydrate kinase FOB88_RS19000 ENOG4108R66 Conserved Protein FOB88_RS19005 ENOG4105DG4 malate L-lactate dehydrogenase FOB88_RS19020 ENOG4105CNN ABC, transporter FOB88_RS19025 ENOG4105C2J ABC transporter FOB88_RS19030 ENOG4105J4Q Transcriptional regulator FOB88_RS19050 ENOG4105TW1 Carbohydrate-selective porin OprB FOB88_RS19055 ENOG4105CPC Aldo Keto reductase FOB88_RS19065 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS19070 ENOG4105VNT transposase (IS4 family) protein FOB88_RS19075 ENOG4105VEQ Cold shock protein FOB88_RS19080 ENOG4105XFK Ferrous iron transport protein A FOB88_RS19085 ENOG4105CE1 Ferrous iron transport protein b FOB88_RS19090 ENOG4105K64 Glycosyl transferase, family 2 FOB88_RS19125 ENOG4108SIC Transcriptional regulator FOB88_RS19135 ENOG4105VF7 tolerance protein FOB88_RS19140 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOB88_RS19150 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FOB88_RS19155 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOB88_RS19160 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOB88_RS19165 ENOG4108ZVF (LipO)protein FOB88_RS19170 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOB88_RS19175 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOB88_RS19185 ENOG4106BSU Entericidin B FOB88_RS19195 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FOB88_RS19200 ENOG4105C0H protease FOB88_RS19205 ENOG4105C0H protease FOB88_RS19210 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FOB88_RS19215 ENOG4105D6Z AFG1 family ATPase FOB88_RS19220 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOB88_RS19225 ENOG4108UJD 30S ribosomal protein S9 FOB88_RS19230 ENOG4107MKT Stringent starvation protein a FOB88_RS19235 ENOG4105KB2 stringent starvation protein b FOB88_RS19240 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOB88_RS19245 ENOG4105CBC glutamate synthase FOB88_RS19250 ENOG4105BZU Histidine kinase FOB88_RS19255 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FOB88_RS19260 ENOG41080Z8 PHOSPHOCARRIER protein FOB88_RS19265 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOB88_RS19270 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FOB88_RS19275 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FOB88_RS19280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB88_RS19285 ENOG4108IUZ ABC transporter FOB88_RS19290 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FOB88_RS19295 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FOB88_RS19305 ENOG4105C2X Arabinose 5-phosphate isomerase FOB88_RS19310 ENOG4105FEU K -dependent Na -Ca exchanger FOB88_RS19315 ENOG4105DHJ ABC, transporter FOB88_RS19320 ENOG4105CY3 ABC transporter, permease FOB88_RS19325 ENOG4107PE3 Mammalian cell entry related domain protein FOB88_RS19330 ENOG4105E3I toluene tolerance FOB88_RS19335 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FOB88_RS19340 ENOG4105VFK BolA family FOB88_RS19345 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOB88_RS19350 ENOG4105HVQ Regulatory factor of maltose metabolism FOB88_RS19355 ENOG4105EAH synthase FOB88_RS19360 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOB88_RS19365 ENOG4105K46 50S ribosomal protein l27 FOB88_RS19370 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOB88_RS19375 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FOB88_RS19380 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FOB88_RS19385 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOB88_RS19390 ENOG4105HBR Rna-binding protein FOB88_RS19395 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FOB88_RS19400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOB88_RS19405 ENOG4105EEI dihydropteroate synthase FOB88_RS19410 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOB88_RS19415 ENOG4105NTZ Preprotein translocase subunit SecG FOB88_RS19430 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOB88_RS19435 ENOG4105CHV Transcription elongation factor NusA FOB88_RS19440 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOB88_RS19445 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOB88_RS19450 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOB88_RS19455 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOB88_RS19460 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOB88_RS19475 ENOG4105C1J atp-dependent rna helicase FOB88_RS19480 ENOG4105DEN Luciferase family FOB88_RS19500 ENOG4108YYD acetyltransferase FOB88_RS19505 ENOG41082IR Excinuclease ABC C subunit domain protein FOB88_RS19515 ENOG4107R7Y intracellular protease Pfpi family FOB88_RS19520 ENOG4105K4T epimerase FOB88_RS19525 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOB88_RS19530 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOB88_RS19535 ENOG4105E2D ec 3.2.1.52 FOB88_RS19540 ENOG41060NJ transcriptional regulator FOB88_RS19550 ENOG4105CJN penicillin-binding protein FOB88_RS19570 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOB88_RS19575 ENOG4105CEY Amp-dependent synthetase and ligase FOB88_RS19580 ENOG4107S74 Lysophospholipid transporter LplT FOB88_RS19590 ENOG4108W2Y isochorismatase FOB88_RS19595 ENOG4105KME endoribonuclease L-psp FOB88_RS19600 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FOB88_RS19605 ENOG4105CXT aspartate transcarbamylase FOB88_RS19610 ENOG4105DBV ornithine carbamoyltransferase FOB88_RS19615 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FOB88_RS19620 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FOB88_RS19625 ENOG4108MJ3 acetyltransferase FOB88_RS19635 ENOG4105MYG DNA polymerase iii, chi subunit FOB88_RS19640 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOB88_RS19645 ENOG4108M8S permease YjgP YjgQ family protein FOB88_RS19650 ENOG4108K5H permease YjgP YjgQ family protein FOB88_RS19670 ENOG4105CNN ABC, transporter FOB88_RS19675 ENOG4105C2J ABC transporter FOB88_RS19680 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS19700 ENOG4106BRA Membrane FOB88_RS19720 ENOG4105D7A ATP-binding protein FOB88_RS19730 ENOG41082NP Multiple antibiotic resistance FOB88_RS19740 ENOG4105RI1 glycoprotein receptor FOB88_RS19935 ENOG4105C7K acetolactate synthase FOB88_RS19955 ENOG4108RVA ribokinase FOB88_RS19960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB88_RS19965 ENOG4108R66 Conserved Protein FOB88_RS19970 ENOG4108I5G Major Facilitator superfamily FOB88_RS20015 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FOB88_RS20020 ENOG4105CKK Glycosyl transferase, family 2 FOB88_RS20045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB88_RS20055 ENOG4105C2D reductase FOB88_RS20060 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB88_RS20065 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FOB88_RS20075 ENOG4105DYC esterase FOB88_RS20090 ENOG4105C5I Dehydrogenase FOB88_RS20095 ENOG41061GT Aldolase FOB88_RS20100 ENOG4105CPQ Dehydrogenase FOB88_RS20130 ENOG4105C8Y Acetylornithine aminotransferase FOB88_RS20140 ENOG4105F5H Glycosyl Hydrolase Family 88 FOB88_RS20145 ENOG4105CHR reductase FOB88_RS20150 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) FOB88_RS20190 ENOG4105CXK mandelate racemase muconate lactonizing FOB88_RS20195 ENOG4105CHR reductase FOB88_RS20200 ENOG4105CPQ Dehydrogenase FOB88_RS20215 ENOG4106RHG Yeca family FOB88_RS20265 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS20275 ENOG4105JHE Major Facilitator Superfamily FOB88_RS20280 ENOG4108UIN ybak prolyl-trna synthetase associated region FOB88_RS20285 ENOG4105BZU Histidine kinase FOB88_RS20290 ENOG4105YBH Protein of unknown function (DUF1435) FOB88_RS20310 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FOB88_RS20315 ENOG4108WPU DNA polymerase III subunit psi FOB88_RS20320 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOB88_RS20325 ENOG4105PAD Hydrolase FOB88_RS20330 ENOG41062Z9 Membrane FOB88_RS20335 ENOG4105EAC phosphoserine phosphatase FOB88_RS20340 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOB88_RS20345 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FOB88_RS20365 ENOG4108VCD Chaperone FOB88_RS20380 ENOG4105GQR Chaperone FOB88_RS20390 ENOG4105EXG Transcriptional regulator FOB88_RS20395 ENOG4105C5H ABC transporter FOB88_RS20400 ENOG4107FB0 transcriptional regulator DeoR family FOB88_RS20405 ENOG4108RVA ribokinase FOB88_RS20415 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FOB88_RS20420 ENOG4105DUU IucA IucC family protein FOB88_RS20425 ENOG4107QF7 multi-drug FOB88_RS20430 ENOG4105E0K tonB-dependent siderophore receptor FOB88_RS20435 ENOG4108IV0 ABC, transporter FOB88_RS20440 ENOG4108IJ6 ABC transporter FOB88_RS20450 ENOG4105C32 Amino acid ABC transporter (Permease) FOB88_RS20460 ENOG4105DRR Transcriptional regulator, GntR family FOB88_RS20465 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOB88_RS20475 ENOG4107SC1 transglycosylase FOB88_RS20480 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FOB88_RS20485 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOB88_RS20490 ENOG4105CVJ phosphoglycerate mutase FOB88_RS20495 ENOG4105UEI Transcriptional Regulator AraC Family FOB88_RS20500 ENOG4108RH0 Crea protein FOB88_RS20505 ENOG41065U4 response regulator FOB88_RS20510 ENOG4106FVC RNA methyltransferase FOB88_RS20520 ENOG4105CFH Aspartokinase FOB88_RS20525 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOB88_RS20535 ENOG4105D1Q UPF0246 protein FOB88_RS20540 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOB88_RS20545 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOB88_RS20555 ENOG4106HK8 GPR1 FUN34 yaaH family protein FOB88_RS20565 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOB88_RS20570 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOB88_RS20575 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOB88_RS20580 ENOG4105DTN riboflavin biosynthesis protein ribF FOB88_RS20585 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOB88_RS20590 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOB88_RS20595 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FOB88_RS20600 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOB88_RS20610 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOB88_RS20615 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOB88_RS20630 ENOG4105CR8 Transcriptional regulator FOB88_RS20640 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOB88_RS20645 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOB88_RS20650 ENOG4105NWN ApaG protein FOB88_RS20655 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOB88_RS20660 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOB88_RS20665 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOB88_RS20670 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FOB88_RS20680 ENOG4105D3G Pseudouridine synthase FOB88_RS20685 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FOB88_RS20690 ENOG4105CQ2 DNA polymerase FOB88_RS20695 ENOG4108KF1 Membrane FOB88_RS20700 ENOG4107T0D ABC, transporter FOB88_RS20705 ENOG4106SMU thiamine transporter membrane protein FOB88_RS20710 ENOG4105DP9 ABC transporter FOB88_RS20720 ENOG4105S8Q sugar efflux transporter FOB88_RS20725 ENOG4105DJB Major Facilitator Superfamily FOB88_RS20730 ENOG4105C5Q Transcriptional regulator FOB88_RS20740 ENOG4105EMV Major Facilitator FOB88_RS20755 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOB88_RS20760 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOB88_RS20770 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOB88_RS20780 ENOG4105C7K acetolactate synthase FOB88_RS20785 ENOG4108ZP8 Acetolactate synthase small subunit FOB88_RS20790 ENOG4107B7Y DNA-binding transcriptional regulator FruR FOB88_RS20795 ENOG4108V6E Cell division protein mraZ FOB88_RS20800 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOB88_RS20805 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOB88_RS20810 ENOG4105CJN penicillin-binding protein FOB88_RS20815 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOB88_RS20820 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FOB88_RS20825 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOB88_RS20830 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOB88_RS20835 ENOG4105CNI cell division protein FtsW FOB88_RS20850 ENOG4105CPF Cell wall formation (By similarity) FOB88_RS20855 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FOB88_RS20860 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOB88_RS20865 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOB88_RS20870 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB88_RS20875 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FOB88_RS20880 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOB88_RS20885 ENOG4105M6F mutator MutT protein FOB88_RS20890 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FOB88_RS20895 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FOB88_RS20900 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOB88_RS20905 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOB88_RS20910 ENOG4105D7Q type ii secretion system FOB88_RS20915 ENOG4107QHF type ii secretion system protein e FOB88_RS20920 ENOG4108ZUW Major pilin subunit FOB88_RS20925 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOB88_RS20930 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOB88_RS20935 ENOG4106A72 regulatory protein AmpE FOB88_RS20940 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOB88_RS20945 ENOG4105CT4 transporter FOB88_RS20950 ENOG4105C85 amino acid FOB88_RS20955 ENOG41073TP transcriptional regulator FOB88_RS20960 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOB88_RS20965 ENOG4107QSN dihydrolipoamide acetyltransferase FOB88_RS20970 ENOG4107QN2 dihydrolipoyl dehydrogenase FOB88_RS20975 ENOG410642W LysR family Transcriptional regulator FOB88_RS20980 ENOG4105CPC Aldo Keto reductase FOB88_RS20985 ENOG4107QIJ Aconitate hydratase 2 FOB88_RS20995 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FOB88_RS21000 ENOG4107S2N Type III effector Hrp-dependent FOB88_RS21005 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS21020 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOB88_RS21025 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOB88_RS21030 ENOG4108ZRK uncharacterized protein yacC FOB88_RS21035 ENOG4105E3B Multicopper oxidase FOB88_RS21040 ENOG4105C28 cystathionine FOB88_RS21045 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOB88_RS21050 ENOG41077A9 carbonic anhydrase FOB88_RS21055 ENOG4105DA5 (ABC) transporter FOB88_RS21060 ENOG4105E3A (ABC) transporter FOB88_RS21065 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FOB88_RS21070 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOB88_RS21075 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOB88_RS21080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOB88_RS21085 ENOG4105DJ0 Poly(A) Polymerase FOB88_RS21090 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FOB88_RS21100 ENOG4105PW4 Sugar fermentation stimulation protein homolog FOB88_RS21105 ENOG4107XID 2'-5' rna ligase FOB88_RS21110 ENOG4105CQ7 ATP-dependent helicase FOB88_RS21115 ENOG4105BZ4 penicillin-binding protein FOB88_RS21120 ENOG4105E0K tonB-dependent siderophore receptor FOB88_RS21125 ENOG4105E0A ABC, transporter FOB88_RS21130 ENOG4105J76 Periplasmic binding protein FOB88_RS21135 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOB88_RS21140 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOB88_RS21145 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOB88_RS21160 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOB88_RS21170 ENOG4105C0H protease FOB88_RS21175 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FOB88_RS21185 ENOG4108T8E UPF0325 protein FOB88_RS21190 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FOB88_RS21195 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOB88_RS21200 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOB88_RS21205 ENOG4105CE9 30S ribosomal protein S2 FOB88_RS21210 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOB88_RS21215 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOB88_RS21220 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOB88_RS21225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOB88_RS21230 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOB88_RS21235 ENOG4105KNE Phosphatidate cytidylyltransferase FOB88_RS21245 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOB88_RS21250 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FOB88_RS21255 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB88_RS21260 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOB88_RS21265 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB88_RS21270 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB88_RS21275 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOB88_RS21280 ENOG4105C0B DNA polymerase III (alpha subunit) FOB88_RS21285 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOB88_RS21290 ENOG4105CXN decarboxylase FOB88_RS21295 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOB88_RS21300 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOB88_RS21310 ENOG4105M1T rho-binding antiterminator FOB88_RS21320 ENOG4108YZN class I peptide chain release factor FOB88_RS21325 ENOG4105VNT transposase (IS4 family) protein FOB88_RS21335 ENOG4108R96 Methyltransferase, YaeB family FOB88_RS21340 ENOG4108R8X outer membrane lipoprotein FOB88_RS21345 ENOG4105D01 (LipO)protein FOB88_RS21350 ENOG4108UMI ABC transporter, permease FOB88_RS21360 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOB88_RS21390 ENOG4105J0Q Transcriptional regulator FOB88_RS21400 ENOG4105CSH Transporter FOB88_RS21405 ENOG4105JIM Phosphatidylserine synthase FOB88_RS21410 ENOG4105CD5 CoA-binding domain protein FOB88_RS21415 ENOG4106IUH DTW domain containing protein FOB88_RS21420 ENOG4105K63 Thioredoxin FOB88_RS21425 ENOG4105EIB trna rrna methyltransferase FOB88_RS21435 ENOG4105DQ4 alcohol dehydrogenase FOB88_RS21440 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS21445 ENOG4105CW7 secretion protein, HlyD family FOB88_RS21450 ENOG4105NTK Transcriptional repressor Mpra FOB88_RS21460 ENOG4105GIJ Glycine betaine FOB88_RS21465 ENOG4108HQS Glycine betaine FOB88_RS21470 ENOG4108IJ7 Glycine betaine FOB88_RS21475 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB88_RS21480 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB88_RS21485 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOB88_RS21490 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FOB88_RS21495 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FOB88_RS21500 ENOG4108WMJ Protein of unknown function (DUF2002) FOB88_RS21505 ENOG4108IQI permease FOB88_RS21510 ENOG4107QK5 Homocysteine s-methyltransferase FOB88_RS21520 ENOG4108MK9 spermidine N(1)-acetyltransferase FOB88_RS21525 ENOG4108JQ7 (ABC) transporter FOB88_RS21530 ENOG4105C3U ABC transporter FOB88_RS21535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS21540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB88_RS21545 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB88_RS21550 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOB88_RS21570 ENOG4105E0A ABC, transporter FOB88_RS21575 ENOG4105EHG Permease protein FOB88_RS21590 ENOG4105BZU Histidine kinase FOB88_RS21595 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB88_RS21610 ENOG4105BZS acriflavin resistance protein FOB88_RS21630 ENOG410642W LysR family Transcriptional regulator FOB88_RS21635 ENOG4108X0B nad(p)h dehydrogenase (quinone) FOB88_RS21645 ENOG4105KVH Transcriptional regulator FOB88_RS21650 ENOG4105CB2 alcohol dehydrogenase FOB88_RS21675 ENOG4108JQ1 Dehydrogenase FOB88_RS21680 ENOG4105JSC dimethylmenaquinone methyltransferase FOB88_RS21685 ENOG4107258 Transcriptional regulator FOB88_RS21690 ENOG4108IPW abc transporter atp-binding protein FOB88_RS21695 ENOG4105CM4 permease protein FOB88_RS21710 ENOG4105D05 Receptor FOB88_RS21740 ENOG4106QCB CP4-57 prophage FOB88_RS21750 ENOG4105DZR Type I site-specific deoxyribonuclease FOB88_RS21770 ENOG4105DFP Integrase FOB88_RS21780 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOB88_RS21785 ENOG4108Z1B Cyclase dehydrase FOB88_RS21790 ENOG4105VDB UPF0125 protein FOB88_RS21795 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB88_RS21800 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOB88_RS21805 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOB88_RS21810 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOB88_RS21825 ENOG4105C1J atp-dependent rna helicase FOB88_RS21830 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FOB88_RS21835 ENOG4108IYU L-aspartate oxidase FOB88_RS21850 ENOG4105VQK sigma E regulatory protein, MucB RseB FOB88_RS21855 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FOB88_RS21860 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOB88_RS21865 ENOG4105C3F Signal peptidase i FOB88_RS21870 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOB88_RS21875 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOB88_RS21880 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FOB88_RS21885 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FOB88_RS21890 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOB88_RS21895 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FOB88_RS21900 ENOG4106G6Q Transcriptional regulator FOB88_RS21905 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FOB88_RS21910 ENOG4108Z6B deaminase FOB88_RS21915 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FOB88_RS21920 ENOG4108ETH Formylglycinamide ribotide synthetase FOB88_RS21925 ENOG4107WP9 Histidine kinase FOB88_RS21930 ENOG4108SKK alpha helix protein FOB88_RS21935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB88_RS21945 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOB88_RS21955 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOB88_RS21960 ENOG4105D8G Major Facilitator superfamily FOB88_RS21965 ENOG4108MN2 Stationary phase inducible protein CsiE FOB88_RS21975 ENOG4105D7X high-affinity nickel-transporter FOB88_RS21985 ENOG4105ECY inositol monophosphatase FOB88_RS21990 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FOB88_RS21995 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FOB88_RS22000 ENOG4105C3J Cysteine desulfurase FOB88_RS22005 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOB88_RS22010 ENOG4105YYA enhanced serine sensitivity protein SseB FOB88_RS22015 ENOG4105KHC sulfurtransferase FOB88_RS22020 ENOG4105DN3 alpha-2-macroglobulin domain protein FOB88_RS22025 ENOG4108JQB penicillin-binding protein 1C FOB88_RS22030 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOB88_RS22035 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOB88_RS22045 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) FOB88_RS22055 ENOG4105CUT histidyl-tRNA synthetase FOB88_RS22060 ENOG4105N21 Membrane FOB88_RS22065 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB88_RS22070 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOB88_RS22075 ENOG4105VPD cellular component movement FOB88_RS22080 ENOG4105DZG Dehydrogenase FOB88_RS22090 ENOG4105D4Y metalloprotease FOB88_RS22100 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOB88_RS22105 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOB88_RS22150 ENOG4105CJW magnesium transporter FOB88_RS22160 ENOG41088CC tellurite resistance protein tehB FOB88_RS22165 ENOG4105C9X ppx gppa phosphatase FOB88_RS22170 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOB88_RS22175 ENOG4105C8U phosphate abc transporter FOB88_RS22185 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS22190 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOB88_RS22195 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOB88_RS22200 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOB88_RS22210 ENOG4105C2W permease FOB88_RS22215 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FOB88_RS22220 ENOG4105K89 arsenate reductase FOB88_RS22225 ENOG4105ERG peptidase m48, ste24p FOB88_RS22230 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS22240 ENOG4107RCV ABC transporter, permease FOB88_RS22245 ENOG4105E0C molybdate abc transporter FOB88_RS22250 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS22255 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOB88_RS22260 ENOG4105BZU Histidine kinase FOB88_RS22270 ENOG4105CT4 transporter FOB88_RS22280 ENOG4105C02 permease FOB88_RS22285 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOB88_RS22290 ENOG4105RH4 Glycine cleavage system transcriptional repressor FOB88_RS22295 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB88_RS22300 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB88_RS22305 ENOG4105C8V SAICAR synthetase FOB88_RS22310 ENOG4105CGZ zinc metallopeptidase FOB88_RS22315 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FOB88_RS22320 ENOG4106KED esterase YpfH FOB88_RS22330 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOB88_RS22335 ENOG4105KUZ arsenate reductase FOB88_RS22345 ENOG4105BZS acriflavin resistance protein FOB88_RS22350 ENOG4105WH1 Two component transcriptional regulator luxr family FOB88_RS22355 ENOG4105BZU Histidine kinase FOB88_RS22365 ENOG4105C85 amino acid FOB88_RS22370 ENOG4107VIJ nudix hydrolase FOB88_RS22375 ENOG4108RVA ribokinase FOB88_RS22380 ENOG4105DKQ ROK family FOB88_RS22385 ENOG4105UP7 3-epimerase FOB88_RS22390 ENOG41062B0 ABC transporter, permease FOB88_RS22395 ENOG4105CNN ABC, transporter FOB88_RS22400 ENOG4105C2J ABC transporter FOB88_RS22410 ENOG4105E98 transcriptional regulator DeoR family FOB88_RS22415 ENOG4108PVD exported protein FOB88_RS22420 ENOG4107R6D beta-lactam binding protein AmpH FOB88_RS22425 ENOG4106YYS transcriptional regulatory protein FOB88_RS22430 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOB88_RS22435 ENOG4105D2K citrate carrier protein FOB88_RS22440 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOB88_RS22445 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOB88_RS22450 ENOG4105C6K Malic enzyme FOB88_RS22455 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FOB88_RS22460 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FOB88_RS22465 ENOG4108R6G acetyltransferase FOB88_RS22470 ENOG4105QZU Inner membrane protein YfeZ FOB88_RS22475 ENOG4105E7K (LipO)protein FOB88_RS22480 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FOB88_RS22485 ENOG4108I5D sulfate abc transporter FOB88_RS22490 ENOG4105ECW sulfate abc transporter FOB88_RS22495 ENOG4108IJ6 ABC transporter FOB88_RS22500 ENOG4105C6T cysteine synthase FOB88_RS22505 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB88_RS22510 ENOG4105E0F Histidine kinase FOB88_RS22515 ENOG4105C5Y PTS System FOB88_RS22520 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOB88_RS22525 ENOG4105KZ7 phosphocarrier protein hpr FOB88_RS22530 ENOG4105C6T cysteine synthase FOB88_RS22535 ENOG4105EXN Sulfate transport protein CysZ FOB88_RS22545 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOB88_RS22550 ENOG4105VRT cytoplasmic protein FOB88_RS22555 ENOG4105DHU Bile acid FOB88_RS22560 ENOG4108M0I Transcriptional regulator FOB88_RS22600 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOB88_RS22605 ENOG4105HZG regulatoR FOB88_RS22610 ENOG4105TMB Formate nitrite transporter FOB88_RS22655 ENOG4105D9N nucleoside FOB88_RS22660 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOB88_RS22675 ENOG4105CPC Aldo Keto reductase FOB88_RS22680 ENOG4107RA9 decarboxylase FOB88_RS22685 ENOG4105CHC glucokinase (EC 2.7.1.2) FOB88_RS22690 ENOG4105DY9 regulatoR FOB88_RS22695 ENOG4108HRK Histidine kinase FOB88_RS22705 ENOG4105CHM Aminotransferase FOB88_RS22750 ENOG4105FCD Major Facilitator FOB88_RS22785 ENOG4105EG2 ABC transporter, permease FOB88_RS22790 ENOG4108IJ9 (ABC) transporter FOB88_RS22795 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOB88_RS22920 ENOG4105S64 Formate nitrite transporter FOB88_RS22930 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FOB88_RS22935 ENOG41060IM Heme exporter protein FOB88_RS22940 ENOG4105X3C heme exporter protein FOB88_RS22945 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FOB88_RS22950 ENOG4105DA4 cytochrome c-type biogenesis protein FOB88_RS22960 ENOG4105KWW Biogenesis protein FOB88_RS22965 ENOG4105KWW Biogenesis protein FOB88_RS22970 ENOG410903C (LipO)protein FOB88_RS22975 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB88_RS22980 ENOG4105KZW UPF0381 protein FOB88_RS22985 ENOG4105CHU acetyl-coa acetyltransferase FOB88_RS22990 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOB88_RS22995 ENOG4108BY2 phosphohistidine phosphatase FOB88_RS23000 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS23010 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FOB88_RS23015 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOB88_RS23025 ENOG4105EJ9 Membrane FOB88_RS23030 ENOG4108BPE -transporting atpase FOB88_RS23035 ENOG4105MH2 YfcL protein FOB88_RS23040 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FOB88_RS23045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB88_RS23055 ENOG4107YZP Rhodanese domain protein FOB88_RS23060 ENOG4106WZ1 flagella biosynthesis regulator FOB88_RS23085 ENOG4105DHQ Histidine kinase FOB88_RS23100 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOB88_RS23110 ENOG4105DQR SNARE associated Golgi FOB88_RS23115 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOB88_RS23120 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOB88_RS23125 ENOG4108S3P Sporulation domain protein FOB88_RS23130 ENOG4105E96 Colicin v production protein FOB88_RS23135 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOB88_RS23140 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOB88_RS23145 ENOG4105E89 ABC transporter FOB88_RS23150 ENOG4105DSP amino acid AbC transporter FOB88_RS23155 ENOG4106YG3 ABC transporter FOB88_RS23160 ENOG4108JEH abc transporter atp-binding protein FOB88_RS23170 ENOG4105DEI Mannitol dehydrogenase FOB88_RS23175 ENOG4105CMG Carbohydrate kinase FOB88_RS23180 ENOG4105IE8 Alpha-ketoglutarate permease FOB88_RS23185 ENOG4105ECP epimerase FOB88_RS23190 ENOG4108SHQ Glutathione S-transferase FOB88_RS23195 ENOG4105PTV Nudix Hydrolase FOB88_RS23205 ENOG4105F38 ABC transporter, permease FOB88_RS23215 ENOG4108JPW Aminotransferase FOB88_RS23225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB88_RS23230 ENOG4105C6K Malic enzyme FOB88_RS23235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOB88_RS23240 ENOG4105PQ6 UPF0208 membrane protein FOB88_RS23245 ENOG4105XWI UPF0304 protein FOB88_RS23250 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FOB88_RS23255 ENOG4105DK2 UPF0207 protein FOB88_RS23260 ENOG4105CHM Aminotransferase FOB88_RS23265 ENOG4107NQ8 LysR family Transcriptional regulator FOB88_RS23270 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOB88_RS23275 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOB88_RS23280 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOB88_RS23285 ENOG4105GKE subunit e FOB88_RS23290 ENOG4107QIZ NADH dehydrogenase FOB88_RS23295 ENOG4108IEH NADH dehydrogenase subunit g FOB88_RS23300 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FOB88_RS23305 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOB88_RS23310 ENOG4107UFS subunit j FOB88_RS23315 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOB88_RS23320 ENOG4105D65 subunit l FOB88_RS23325 ENOG4105C8S subunit m FOB88_RS23330 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOB88_RS23340 ENOG4107YB6 acetyltransferase, (GNAT) family FOB88_RS23350 ENOG4105TNS Conserved Protein FOB88_RS23360 ENOG4105XPH Ferredoxin FOB88_RS23365 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB88_RS23370 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB88_RS23375 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOB88_RS23380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB88_RS23385 ENOG4105BZU Histidine kinase FOB88_RS23390 ENOG41068CG regulatoR FOB88_RS23395 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FOB88_RS23400 ENOG4106UW1 Major Facilitator superfamily FOB88_RS23415 ENOG4105BZ1 (ABC) transporter FOB88_RS23425 ENOG4105FCK Membrane FOB88_RS23440 ENOG4105CJ2 (LipO)protein FOB88_RS23445 ENOG4105CF1 Alkylated DNA repair protein FOB88_RS23450 ENOG4105IBP Cyclic peptide transporter FOB88_RS23460 ENOG4105CUY Mechanosensitive ion channel FOB88_RS23465 ENOG4105CT4 transporter FOB88_RS23490 ENOG41067XB TonB family FOB88_RS23500 ENOG4108SF5 RNA Polymerase FOB88_RS23510 ENOG4105CQ0 ABC transporter FOB88_RS23515 ENOG4105K63 Thioredoxin FOB88_RS23520 ENOG4105CMS peptidase U62, modulator of DNA gyrase FOB88_RS23525 ENOG4105D1U peptidase U62 modulator of DNA gyrase FOB88_RS23550 ENOG410679B prophage CP4-57 regulatory protein alpA FOB88_RS23565 ENOG4108FPN Integrase FOB88_RS23630 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOB88_RS23635 ENOG4105D06 uba thif-type nad fad binding protein FOB88_RS23670 ENOG4105DFP Integrase FOB88_RS23680 ENOG4105E68 Sulfatase FOB88_RS23685 ENOG4105YDX UPF0352 protein FOB88_RS23690 ENOG4106V8H Nucleoid-associated protein FOB88_RS23695 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FOB88_RS23700 ENOG4105CFI type iii restriction protein res subunit FOB88_RS23705 ENOG4105I08 Pseudouridine synthase FOB88_RS23710 ENOG4105C2C drug resistance transporter, Bcr CflA FOB88_RS23715 ENOG4105HG6 FOB88_RS23720 ENOG4108JQ5 ABC transporter FOB88_RS23725 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FOB88_RS23730 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FOB88_RS23735 ENOG4105E43 Extracellular solute-binding protein, family 5 FOB88_RS23740 ENOG4105CXC rtn protein FOB88_RS23745 ENOG4107TT5 NLP P60 protein FOB88_RS23750 ENOG41076MN Phosphoesterase, PA-phosphatase related FOB88_RS23755 ENOG4105CKI cobalamin synthesis protein FOB88_RS23760 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOB88_RS23765 ENOG4105KRS Proteinase inhibitor FOB88_RS23770 ENOG41079KZ Major Facilitator Superfamily FOB88_RS23780 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB88_RS23785 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOB88_RS23790 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FOB88_RS23795 ENOG4105DE4 1-phosphofructokinase FOB88_RS23800 ENOG4105DM4 PTS System FOB88_RS23805 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FOB88_RS23815 ENOG4105HMI Membrane FOB88_RS23825 ENOG4105DUM transcriptional regulator, lysR family FOB88_RS23830 ENOG4108IQI permease FOB88_RS23835 ENOG4105EHG Permease protein FOB88_RS23840 ENOG4105E0A ABC, transporter FOB88_RS23845 ENOG4105C4W S-formylglutathione hydrolase FOB88_RS23855 ENOG4105EGI Transcriptional regulator FOB88_RS23860 ENOG4105CBP Major Facilitator FOB88_RS23870 ENOG4105DHF Membrane FOB88_RS23875 ENOG41060NJ transcriptional regulator FOB88_RS23890 ENOG4107SDZ Galactoside transport system permease protein mglC FOB88_RS23895 ENOG4107GZ4 SanA protein FOB88_RS23900 ENOG4107R1I NAD-dependent malic enzyme FOB88_RS23910 ENOG41067MG lrgb family FOB88_RS23915 ENOG4105VAW lrga family FOB88_RS23920 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOB88_RS23925 ENOG4105D1F ATP-binding protein FOB88_RS23930 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FOB88_RS23935 ENOG4105D3R alkyl hydroperoxide reductase FOB88_RS23940 ENOG4108JU3 Alkyl hydroperoxide reductase FOB88_RS23960 ENOG4105DWF phosphomethylpyrimidine kinase FOB88_RS23965 ENOG4107XBN GntR Family Transcriptional Regulator FOB88_RS23970 ENOG4105DEI Mannitol dehydrogenase FOB88_RS23980 ENOG4105CFP Peptidase U32 FOB88_RS23985 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB88_RS23990 ENOG4105EB3 Histidine kinase FOB88_RS23995 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB88_RS24005 ENOG4105BZS acriflavin resistance protein FOB88_RS24015 ENOG4105R8A Heat shock protein FOB88_RS24020 ENOG4105BZU Histidine kinase FOB88_RS24025 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FOB88_RS24030 ENOG4105DBI uridine monophosphokinase FOB88_RS24035 ENOG4105DHP deoxycytidine triphosphate deaminase FOB88_RS24040 ENOG4108GAE asmA family FOB88_RS24045 ENOG4105EE5 Membrane protein terC FOB88_RS24050 ENOG4105D3Q Sugar transferase FOB88_RS24055 ENOG4105DAY polysaccharide export protein FOB88_RS24060 ENOG4107ZF2 Phosphatase FOB88_RS24065 ENOG4105D75 Capsular exopolysaccharide family FOB88_RS24075 ENOG4105JEU Glycosyl transferase, family 2 FOB88_RS24085 ENOG4105CG5 Glycosyl transferase (Group 1 FOB88_RS24095 ENOG4105C74 pyruvyl transferase FOB88_RS24100 ENOG4107T8Q Glycosyl transferase (Group 1 FOB88_RS24105 ENOG4105PSV Polysaccharide Biosynthesis Protein FOB88_RS24110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOB88_RS24115 ENOG4105CMR udp-glucose 4-epimerase FOB88_RS24120 ENOG4105ESV Glycosyl transferase, family 4 FOB88_RS24125 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOB88_RS24130 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOB88_RS24140 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOB88_RS24145 ENOG4108MX3 Polysaccharide Biosynthesis Protein FOB88_RS24160 ENOG4108TJN glycosyl transferase group 1 FOB88_RS24165 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOB88_RS24170 ENOG4105C30 Nad-dependent epimerase dehydratase FOB88_RS24175 ENOG4105FGF GDP-mannose mannosyl hydrolase FOB88_RS24180 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOB88_RS24185 ENOG4105K64 Glycosyl transferase, family 2 FOB88_RS24190 ENOG4107QKV phosphomannomutase FOB88_RS24195 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOB88_RS24210 ENOG4105E89 ABC transporter FOB88_RS24215 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FOB88_RS24230 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOB88_RS24235 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOB88_RS24240 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOB88_RS24245 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOB88_RS24250 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOB88_RS24255 ENOG4105CIH Imidazole acetol-phosphate transaminase FOB88_RS24260 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOB88_RS24265 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOB88_RS24275 ENOG4107SRH Nad-dependent epimerase dehydratase FOB88_RS24280 ENOG4105CJP fad dependent oxidoreductase FOB88_RS24285 ENOG4107VRI Transcriptional regulator FOB88_RS24290 ENOG4108Z86 Glutamine amidotransferase FOB88_RS24295 ENOG4105CFQ glutamine synthetase FOB88_RS24300 ENOG4105CUB amino acid FOB88_RS24305 ENOG4105MVE transcriptional regulator FOB88_RS24310 ENOG4105ZXK Dehydrogenase FOB88_RS24315 ENOG4105G63 Type III effector Hrp-dependent FOB88_RS24320 ENOG4105FB2 class II Aldolase FOB88_RS24325 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FOB88_RS24330 ENOG4105C6Z Gluconate FOB88_RS24335 ENOG4105CJB Exodeoxyribonuclease I FOB88_RS24340 ENOG4105DZ1 carboxypeptidase FOB88_RS24345 ENOG4105DR8 Membrane FOB88_RS24350 ENOG41090HJ UPF0265 protein FOB88_RS24355 ENOG4105ETE Transcriptional regulator (LacI family FOB88_RS24360 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOB88_RS24365 ENOG4108M8W Monooxygenase FOB88_RS24380 ENOG4108WC9 type VI secretion system effector, hcp1 family FOB88_RS24385 ENOG4105C26 Dehydrogenase FOB88_RS24405 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FOB88_RS24420 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FOB88_RS24425 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FOB88_RS24430 ENOG4105F4K antigen 43 FOB88_RS24445 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOB88_RS24460 ENOG4105J7D transcriptional regulator FOB88_RS24505 ENOG410680H amp-dependent synthetase and ligase FOB88_RS24515 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOB88_RS24560 ENOG4105WH1 Two component transcriptional regulator luxr family FOB88_RS24565 ENOG4105BZU Histidine kinase FOB88_RS24570 ENOG4105I6B RNA polymerase FOB88_RS24580 ENOG4108HR8 type iii secretion FOB88_RS24610 ENOG4108HHI Type III secretion system protein FOB88_RS24620 ENOG4108TN6 type iii secretion FOB88_RS24720 ENOG4105C8Q Methyl-accepting chemotaxis FOB88_RS24740 ENOG4105CNN ABC, transporter FOB88_RS24755 ENOG4107R11 Transcriptional regulator FOB88_RS24795 ENOG4108MBX Secretion Protein FOB88_RS24800 ENOG4108JJA ABC, transporter FOB88_RS24805 ENOG4105CK1 PTS System FOB88_RS24820 ENOG4105C26 Dehydrogenase FOB88_RS24830 ENOG4105CJP fad dependent oxidoreductase FOB88_RS24845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB88_RS24865 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOB88_RS24870 ENOG4105CH2 amidohydrolase FOB88_RS24875 ENOG4108JPW Aminotransferase FOB88_RS24880 ENOG4108RYR transcriptional regulator AsnC family FOB88_RS24890 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FOB88_RS24895 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOB88_RS24900 ENOG4107RJJ Transcriptional regulator FOB88_RS24905 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FOB88_RS24910 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH