locus-tag	class	description
LH22_RS00090	COG0629	single-stranded DNA binding
LH22_RS00100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH22_RS00140	COG0305	Participates in initiation and elongation during chromosome replication
LH22_RS00165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH22_RS00170	COG0697	spore germination
LH22_RS00185	COG1984	allophanate hydrolase subunit 2
LH22_RS00190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH22_RS00195	COG0436	Aminotransferase
LH22_RS00210	COG4221	oxidoreductase activity
LH22_RS00220	COG0765	amino acid transport
LH22_RS00230	COG0673	inositol 2-dehydrogenase activity
LH22_RS00250	COG1082	Xylose isomerase domain protein TIM barrel
LH22_RS00255	COG0673	inositol 2-dehydrogenase activity
LH22_RS00265	COG0625	glutathione transferase activity
LH22_RS00275	COG0840	transmembrane signaling receptor activity
LH22_RS00290	COG0673	inositol 2-dehydrogenase activity
LH22_RS00300	COG0300	oxidoreductase activity
LH22_RS00315	COG0583	DNA-binding transcription factor activity
LH22_RS00320	COG0473	3-isopropylmalate dehydrogenase activity
LH22_RS00325	COG0395	ABC-type sugar transport system, permease component
LH22_RS00330	COG1175	transmembrane transport
LH22_RS00350	COG1940	carbohydrate kinase activity
LH22_RS00375	COG4993	Dehydrogenase
LH22_RS00380	COG2814	Major facilitator Superfamily
LH22_RS00390	COG4977	sequence-specific DNA binding
LH22_RS00400	COG0642	Histidine kinase
LH22_RS00410	COG3248	Nucleoside-binding outer membrane protein
LH22_RS00415	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LH22_RS00420	COG0583	DNA-binding transcription factor activity
LH22_RS00425	COG1473	amidohydrolase
LH22_RS00430	COG1473	amidohydrolase
LH22_RS00435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LH22_RS00440	COG2271	Major facilitator Superfamily
LH22_RS00460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LH22_RS00485	COG2207	Transcriptional regulator
LH22_RS00490	COG0840	transmembrane signaling receptor activity
LH22_RS00500	COG1263	PTS System
LH22_RS00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS00505	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LH22_RS00510	COG1301	dicarboxylic acid transport
LH22_RS00515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH22_RS00520	COG3162	membrane
LH22_RS00525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH22_RS00535	COG1346	cytolysis
LH22_RS00545	COG0583	DNA-binding transcription factor activity
LH22_RS00550	COG0025	NhaP-type Na H and K H
LH22_RS00555	COG2252	PERMEase
LH22_RS00570	COG0789	Transcriptional regulator
LH22_RS00575	COG2207	Transcriptional regulator
LH22_RS00600	COG0697	spore germination
LH22_RS00605	COG2207	Transcriptional regulator
LH22_RS00615	COG0758	DNA mediated transformation
LH22_RS00620	COG0514	ATP-dependent DNA helicase (RecQ)
LH22_RS00625	COG0629	single-stranded DNA binding
LH22_RS00635	COG1064	alcohol dehydrogenase
LH22_RS00640	COG2315	Protein conserved in bacteria
LH22_RS00645	COG1448	Aminotransferase
LH22_RS00655	COG1522	sequence-specific DNA binding
LH22_RS00675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH22_RS00685	COG2084	Dehydrogenase
LH22_RS00690	COG3958	Transketolase
LH22_RS00695	COG3959	Transketolase, thiamine diphosphate binding domain
LH22_RS00700	COG0583	DNA-binding transcription factor activity
LH22_RS00710	COG0735	belongs to the Fur family
LH22_RS00720	COG0534	Mate efflux family protein
LH22_RS00730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH22_RS00745	COG3161	chorismate lyase activity
LH22_RS00750	COG3223	Belongs to the PsiE family
LH22_RS00755	COG2188	Transcriptional regulator
LH22_RS00770	COG4149	molybdate abc transporter
LH22_RS00780	COG3842	ATPase activity
LH22_RS00790	COG2610	gluconate transmembrane transporter activity
LH22_RS00795	COG3265	gluconokinase activity
LH22_RS00800	COG1609	Transcriptional regulator
LH22_RS00805	COG1741	Belongs to the pirin family
LH22_RS00810	COG1247	-acetyltransferase
LH22_RS00815	COG0405	Gamma-glutamyltransferase
LH22_RS00825	COG0584	glycerophosphoryl diester phosphodiesterase
LH22_RS00845	COG1653	transport
LH22_RS00855	COG0411	ABC transporter
LH22_RS00880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH22_RS00885	COG2177	Part of the ABC transporter FtsEX involved in
LH22_RS00890	COG2884	Cell division ATP-binding protein ftsE
LH22_RS00895	COG0552	protein localization to endoplasmic reticulum
LH22_RS00895	COG0552	protein localization to endoplasmic reticulum
LH22_RS00900	COG0742	ribosomal rna small subunit methyltransferase
LH22_RS00905	COG3776	membrane
LH22_RS00915	COG3714	YhhN family
LH22_RS00925	COG0425	Belongs to the sulfur carrier protein TusA family
LH22_RS00930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LH22_RS00940	COG0058	SHG alpha-glucan phosphorylase activity
LH22_RS00945	COG0297	glycogen (starch) synthase activity
LH22_RS00955	COG1523	belongs to the glycosyl hydrolase 13 family
LH22_RS00965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH22_RS00970	COG2095	MarC family integral membrane protein
LH22_RS00980	COG0527	aspartate kinase activity
LH22_RS00985	COG0166	Belongs to the GPI family
LH22_RS01005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS01010	COG1410	methionine synthase
LH22_RS01010	COG0646	methionine synthase
LH22_RS01030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LH22_RS01035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LH22_RS01060	COG0138	bifunctional purine biosynthesis protein purh
LH22_RS01065	COG0151	Belongs to the GarS family
LH22_RS01080	COG3068	Protein conserved in bacteria
LH22_RS01090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH22_RS01095	COG2816	NAD+ diphosphatase activity
LH22_RS01100	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LH22_RS01105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LH22_RS01110	COG0352	thiamine-phosphate diphosphorylase activity
LH22_RS01115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH22_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH22_RS01130	COG0085	RNA polymerase activity
LH22_RS01140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH22_RS01150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH22_RS01155	COG0250	Participates in transcription elongation, termination and antitermination
LH22_RS01160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH22_RS01195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LH22_RS01195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LH22_RS01200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH22_RS01235	COG1739	Uncharacterized protein family UPF0029
LH22_RS01240	COG0006	proline dipeptidase activity
LH22_RS01260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH22_RS01275	COG0084	hydrolase, TatD family'
LH22_RS01280	COG0805	protein transport
LH22_RS01295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH22_RS01300	COG3165	ubiquinone biosynthetic process from chorismate
LH22_RS01305	COG2226	methyltransferase
LH22_RS01310	COG1322	Protein conserved in bacteria
LH22_RS01325	COG0412	Dienelactone hydrolase
LH22_RS01330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH22_RS01335	COG0583	DNA-binding transcription factor activity
LH22_RS01340	COG4807	Protein conserved in bacteria
LH22_RS01350	COG2271	Major facilitator Superfamily
LH22_RS01355	COG0561	phosphatase activity
LH22_RS01360	COG2267	carboxylic ester hydrolase activity
LH22_RS01365	COG1280	lysine exporter protein (LysE YggA)
LH22_RS01370	COG1280	lysine exporter protein (LysE YggA)
LH22_RS01380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LH22_RS01385	COG2050	protein possibly involved in aromatic compounds catabolism
LH22_RS01390	COG2962	Rard protein
LH22_RS01395	COG3180	Ammonia monooxygenase
LH22_RS01405	COG0210	DNA helicase
LH22_RS01410	COG1011	Hydrolase
LH22_RS01425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LH22_RS01440	COG0181	hydroxymethylbilane synthase activity
LH22_RS01445	COG1587	Uroporphyrinogen-III synthase
LH22_RS01450	COG2959	enzyme of heme biosynthesis
LH22_RS01455	COG3071	HemY protein
LH22_RS01490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH22_RS01495	COG2244	polysaccharide biosynthetic process
LH22_RS01500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH22_RS01505	COG0456	acetyltransferase
LH22_RS01510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LH22_RS01515	COG1088	dTDP-glucose 4,6-dehydratase activity
LH22_RS01520	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LH22_RS01525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH22_RS01530	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LH22_RS01535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH22_RS01540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH22_RS01545	COG3118	belongs to the thioredoxin family
LH22_RS01550	COG0513	Belongs to the DEAD box helicase family
LH22_RS01555	COG0248	Ppx GppA phosphatase
LH22_RS01560	COG0210	DNA helicase
LH22_RS01565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH22_RS01570	COG2982	Protein involved in outer membrane biogenesis
LH22_RS01575	COG2200	EAL domain
LH22_RS01580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS01600	COG2199	diguanylate cyclase activity
LH22_RS01600	COG2200	EAL domain
LH22_RS01605	COG2194	sulfuric ester hydrolase activity
LH22_RS01635	COG1215	transferase activity, transferring glycosyl groups
LH22_RS01640	COG0457	Tetratricopeptide repeat
LH22_RS01640	COG3118	belongs to the thioredoxin family
LH22_RS01655	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LH22_RS01670	COG1215	transferase activity, transferring glycosyl groups
LH22_RS01675	COG1215	transferase activity, transferring glycosyl groups
LH22_RS01680	COG0489	protein tyrosine kinase activity
LH22_RS01690	COG4608	Belongs to the ABC transporter superfamily
LH22_RS01695	COG0444	Belongs to the ABC transporter superfamily
LH22_RS01700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS01705	COG0601	transmembrane transport
LH22_RS01710	COG0747	negative chemotaxis
LH22_RS01720	COG2194	sulfuric ester hydrolase activity
LH22_RS01725	COG1764	response to oxidative stress
LH22_RS01730	COG1846	Transcriptional regulator
LH22_RS01740	COG2944	sequence-specific DNA binding
LH22_RS01745	COG0439	Biotin carboxylase
LH22_RS01760	COG1116	anion transmembrane transporter activity
LH22_RS01780	COG0444	Belongs to the ABC transporter superfamily
LH22_RS01785	COG4608	Belongs to the ABC transporter superfamily
LH22_RS01790	COG0747	negative chemotaxis
LH22_RS01800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS01815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS01815	COG2213	PTS system mannitol-specific
LH22_RS01825	COG3722	fumarate hydratase activity
LH22_RS01835	COG2990	Protein conserved in bacteria
LH22_RS01840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH22_RS01845	COG1609	Transcriptional regulator
LH22_RS01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS01865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH22_RS01870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH22_RS01875	COG1349	DNA-binding transcription factor activity
LH22_RS01885	COG3383	formate dehydrogenase (NAD+) activity
LH22_RS01885	COG0243	molybdopterin cofactor binding
LH22_RS01890	COG0243	molybdopterin cofactor binding
LH22_RS01890	COG3383	formate dehydrogenase (NAD+) activity
LH22_RS01895	COG0437	4 iron, 4 sulfur cluster binding
LH22_RS01900	COG2864	formate dehydrogenase
LH22_RS01910	COG0625	glutathione transferase activity
LH22_RS01915	COG1921	L-seryl-tRNASec selenium transferase activity
LH22_RS01920	COG3276	selenocysteine insertion sequence binding
LH22_RS01935	COG0751	glycine-tRNA ligase activity
LH22_RS01945	COG0251	oxidation-reduction process
LH22_RS01960	COG1126	abc transporter atp-binding protein
LH22_RS01975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH22_RS01980	COG1802	Transcriptional regulator
LH22_RS01985	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS01990	COG3274	enterobacterial common antigen metabolic process
LH22_RS02000	COG1070	Carbohydrate kinase
LH22_RS02030	COG1609	Transcriptional regulator
LH22_RS02035	COG2814	Major facilitator Superfamily
LH22_RS02040	COG1940	carbohydrate kinase activity
LH22_RS02045	COG1484	DNA-dependent DNA replication
LH22_RS02055	COG5571	outer membrane autotransporter
LH22_RS02060	COG2818	Glycosylase
LH22_RS02065	COG2885	chlorophyll binding
LH22_RS02075	COG1609	Transcriptional regulator
LH22_RS02085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS02100	COG3977	Valine--pyruvate aminotransferase
LH22_RS02105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH22_RS02130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH22_RS02135	COG0697	spore germination
LH22_RS02140	COG3385	transposase activity
LH22_RS02150	COG5645	(Lipo)protein
LH22_RS02155	COG0823	Involved in the tonB-independent uptake of proteins
LH22_RS02160	COG2271	Major facilitator Superfamily
LH22_RS02165	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS02170	COG0800	Aldolase
LH22_RS02175	COG3734	2-keto-3-deoxy-galactonokinase
LH22_RS02180	COG2186	Transcriptional regulator
LH22_RS02185	COG0561	phosphatase activity
LH22_RS02200	COG0187	DNA topoisomerase II activity
LH22_RS02205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LH22_RS02210	COG0592	DNA-directed DNA polymerase activity
LH22_RS02215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH22_RS02220	COG0594	ribonuclease P activity
LH22_RS02225	COG0706	membrane insertase activity
LH22_RS02235	COG0778	Nitroreductase
LH22_RS02240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH22_RS02245	COG2091	lysine biosynthetic process via aminoadipic acid
LH22_RS02250	COG2252	PERMEase
LH22_RS02255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH22_RS02260	COG2814	Major facilitator Superfamily
LH22_RS02265	COG0704	Plays a role in the regulation of phosphate uptake
LH22_RS02270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH22_RS02275	COG0581	inorganic phosphate transmembrane transporter activity
LH22_RS02280	COG0573	inorganic phosphate transmembrane transporter activity
LH22_RS02285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH22_RS02295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH22_RS02305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH22_RS02310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH22_RS02315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH22_RS02320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH22_RS02325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH22_RS02335	COG0356	it plays a direct role in the translocation of protons across the membrane
LH22_RS02340	COG3312	ion transport
LH22_RS02345	COG0357	Ribosomal RNA small subunit methyltransferase G
LH22_RS02355	COG0716	FMN binding
LH22_RS02360	COG1522	sequence-specific DNA binding
LH22_RS02365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH22_RS02370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LH22_RS02385	COG0642	Histidine kinase
LH22_RS02395	COG3111	PFAM Bacterial OB fold (BOF) protein
LH22_RS02405	COG1129	ABC transporter
LH22_RS02410	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS02415	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS02420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS02425	COG1609	Transcriptional regulator
LH22_RS02430	COG0477	Major facilitator Superfamily
LH22_RS02455	COG1763	Mo-molybdopterin cofactor biosynthetic process
LH22_RS02460	COG0746	molybdenum cofactor guanylyltransferase activity
LH22_RS02465	COG3084	Protein conserved in bacteria
LH22_RS02470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LH22_RS02480	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH22_RS02480	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH22_RS02490	COG3078	GTPase activator activity
LH22_RS02505	COG3852	Histidine kinase
LH22_RS02520	COG1011	Hydrolase
LH22_RS02535	COG0456	acetyltransferase
LH22_RS02540	COG2982	Protein involved in outer membrane biogenesis
LH22_RS02545	COG2233	PERMEase
LH22_RS02550	COG0604	alcohol dehydrogenase
LH22_RS02560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH22_RS02565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH22_RS02570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH22_RS02575	COG1758	RNA polymerase activity
LH22_RS02580	COG0194	GDP metabolic process
LH22_RS02590	COG2860	membrane
LH22_RS02595	COG2244	polysaccharide biosynthetic process
LH22_RS02620	COG1560	Kdo2-lipid A biosynthetic process
LH22_RS02625	COG4580	involved in the transport of maltose and maltodextrins
LH22_RS02630	COG0366	Alpha amylase catalytic
LH22_RS02635	COG1263	PTS System
LH22_RS02635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS02640	COG1609	Transcriptional regulator
LH22_RS02645	COG1561	YicC-like family, N-terminal region
LH22_RS02655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH22_RS02660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH22_RS02670	COG1309	transcriptional regulator
LH22_RS02680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH22_RS02685	COG2003	Belongs to the UPF0758 family
LH22_RS02690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH22_RS02700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH22_RS02715	COG1519	Transferase
LH22_RS02725	COG0859	PFAM glycosyl transferase family 9
LH22_RS02730	COG1216	Glycosyl transferase, family 2
LH22_RS02745	COG0438	transferase activity, transferring glycosyl groups
LH22_RS02755	COG0156	8-amino-7-oxononanoate synthase activity
LH22_RS02760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH22_RS02765	COG0859	PFAM glycosyl transferase family 9
LH22_RS02770	COG0859	PFAM glycosyl transferase family 9
LH22_RS02785	COG0859	PFAM glycosyl transferase family 9
LH22_RS02790	COG2861	carbohydrate metabolic process
LH22_RS02795	COG4942	peptidase
LH22_RS02800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH22_RS02805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH22_RS02815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH22_RS02820	COG1045	serine acetyltransferase
LH22_RS02825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LH22_RS02830	COG2205	protein histidine kinase activity
LH22_RS02835	COG0745	RESPONSE REGULATOR receiver
LH22_RS02840	COG3678	ATP-independent chaperone mediated protein folding
LH22_RS02850	COG0205	6-phosphofructokinase activity
LH22_RS02855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH22_RS02865	COG0149	triose-phosphate isomerase activity
LH22_RS02880	COG2814	Major facilitator Superfamily
LH22_RS02885	COG1494	fructose-1,6-bisphosphatase
LH22_RS02890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH22_RS02895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH22_RS02900	COG3074	FtsZ-dependent cytokinesis
LH22_RS02910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH22_RS02915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH22_RS02920	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LH22_RS02925	COG1609	Transcriptional regulator
LH22_RS02930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH22_RS02935	COG0254	rRNA binding
LH22_RS02940	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LH22_RS02945	COG0626	cystathionine gamma-synthase activity
LH22_RS02950	COG0527	aspartate kinase activity
LH22_RS02950	COG0460	homoserine dehydrogenase
LH22_RS02960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH22_RS02965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH22_RS02975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH22_RS02980	COG0137	argininosuccinate synthase activity
LH22_RS02985	COG0165	Argininosuccinate lyase
LH22_RS02995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH22_RS03015	COG4206	TonB-dependent receptor
LH22_RS03060	COG0583	DNA-binding transcription factor activity
LH22_RS03065	COG3085	chromosome segregation
LH22_RS03070	COG0606	chelatase, subunit chli
LH22_RS03080	COG3978	acetolactate synthase activity
LH22_RS03085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH22_RS03090	COG0129	dihydroxy-acid dehydratase activity
LH22_RS03110	COG0477	Major facilitator Superfamily
LH22_RS03115	COG1295	ribonuclease BN
LH22_RS03120	COG0583	DNA-binding transcription factor activity
LH22_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS03135	COG0625	glutathione transferase activity
LH22_RS03140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH22_RS03160	COG1971	Probably functions as a manganese efflux pump
LH22_RS03175	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS03180	COG4172	Belongs to the ABC transporter superfamily
LH22_RS03190	COG0601	transmembrane transport
LH22_RS03195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS03215	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH22_RS03225	COG4608	Belongs to the ABC transporter superfamily
LH22_RS03230	COG4172	Belongs to the ABC transporter superfamily
LH22_RS03235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS03240	COG0601	transmembrane transport
LH22_RS03265	COG2271	Major facilitator Superfamily
LH22_RS03275	COG1063	alcohol dehydrogenase
LH22_RS03285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH22_RS03290	COG1082	Xylose isomerase domain protein TIM barrel
LH22_RS03290	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LH22_RS03295	COG0400	carboxylic ester hydrolase activity
LH22_RS03300	COG0435	Glutathione S-transferase
LH22_RS03305	COG0583	DNA-binding transcription factor activity
LH22_RS03315	COG1132	(ABC) transporter
LH22_RS03320	COG1247	-acetyltransferase
LH22_RS03330	COG2271	Major facilitator Superfamily
LH22_RS03335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH22_RS03345	COG3093	addiction module antidote protein HigA
LH22_RS03355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LH22_RS03360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH22_RS03365	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH22_RS03375	COG2205	protein histidine kinase activity
LH22_RS03380	COG2862	Uncharacterized protein family, UPF0114
LH22_RS03385	COG0583	DNA-binding transcription factor activity
LH22_RS03390	COG2814	Major facilitator Superfamily
LH22_RS03410	COG3781	membrane
LH22_RS03415	COG1335	isochorismatase
LH22_RS03420	COG0583	DNA-binding transcription factor activity
LH22_RS03425	COG0300	oxidoreductase activity
LH22_RS03430	COG3189	MarR family transcriptional regulator
LH22_RS03450	COG1069	ribulokinase activity
LH22_RS03465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH22_RS03470	COG1234	tRNA 3'-trailer cleavage
LH22_RS03480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH22_RS03490	COG0742	ribosomal rna small subunit methyltransferase
LH22_RS03505	COG0306	phosphate transporter
LH22_RS03510	COG2081	HI0933 family
LH22_RS03525	COG1335	isochorismatase
LH22_RS03540	COG0596	Alpha beta hydrolase
LH22_RS03550	COG0113	porphobilinogen synthase activity
LH22_RS03565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH22_RS03570	COG2200	EAL domain
LH22_RS03575	COG0235	Class ii aldolase
LH22_RS03580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH22_RS03590	COG0628	permease
LH22_RS03595	COG1178	ABC-type Fe3 transport system permease component
LH22_RS03600	COG1840	ABC-type Fe3 transport system, periplasmic component
LH22_RS03605	COG3842	ATPase activity
LH22_RS03610	COG0477	Major facilitator Superfamily
LH22_RS03625	COG3718	enzyme involved in inositol metabolism
LH22_RS03635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS03640	COG3962	Belongs to the TPP enzyme family
LH22_RS03645	COG0673	inositol 2-dehydrogenase activity
LH22_RS03650	COG1082	Xylose isomerase domain protein TIM barrel
LH22_RS03655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH22_RS03660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH22_RS03670	COG1349	DNA-binding transcription factor activity
LH22_RS03675	COG0058	SHG alpha-glucan phosphorylase activity
LH22_RS03680	COG1640	4-alpha-glucanotransferase
LH22_RS03685	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH22_RS03685	COG0316	Belongs to the HesB IscA family
LH22_RS03690	COG1040	competence protein
LH22_RS03695	COG2267	carboxylic ester hydrolase activity
LH22_RS03700	COG0366	Alpha amylase catalytic
LH22_RS03705	COG2183	response to ionizing radiation
LH22_RS03710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH22_RS03730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LH22_RS03735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH22_RS03740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LH22_RS03745	COG1011	Hydrolase
LH22_RS03755	COG0494	nUDIX hydrolase
LH22_RS03760	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH22_RS03785	COG4796	Type ii and iii secretion system protein
LH22_RS03800	COG3266	domain, Protein
LH22_RS03810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH22_RS03840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH22_RS03845	COG0402	S-adenosylhomocysteine deaminase activity
LH22_RS03850	COG0738	Major facilitator superfamily
LH22_RS03855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH22_RS03880	COG1289	transmembrane transporter activity
LH22_RS03890	COG1765	OsmC-like protein
LH22_RS03895	COG3954	Phosphoribulokinase
LH22_RS03900	COG3089	Belongs to the UPF0270 family
LH22_RS03905	COG0429	hydrolase of the alpha beta-hydrolase fold
LH22_RS03915	COG1609	Transcriptional regulator
LH22_RS03920	COG4521	taurine ABC transporter
LH22_RS03930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH22_RS03935	COG2175	clavaminate synthase activity
LH22_RS03940	COG0488	(ABC) transporter
LH22_RS03945	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH22_RS03950	COG0475	glutathione-regulated potassium exporter activity
LH22_RS03950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH22_RS03955	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LH22_RS03960	COG1047	Peptidyl-prolyl cis-trans
LH22_RS03965	COG2900	Belongs to the SlyX family
LH22_RS03970	COG0545	Peptidyl-prolyl cis-trans isomerase
LH22_RS03975	COG2964	Protein conserved in bacteria
LH22_RS03995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH22_RS04000	COG0049	tRNA binding
LH22_RS04005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH22_RS04025	COG0051	transcription antitermination factor activity, RNA binding
LH22_RS04035	COG0088	Forms part of the polypeptide exit tunnel
LH22_RS04040	COG0089	rRNA binding
LH22_RS04050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH22_RS04065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH22_RS04070	COG0255	Belongs to the universal ribosomal protein uL29 family
LH22_RS04075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH22_RS04080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH22_RS04095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH22_RS04105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LH22_RS04110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LH22_RS04115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH22_RS04120	COG1841	ribosomal large subunit assembly
LH22_RS04125	COG0200	Binds to the 23S rRNA
LH22_RS04130	COG0201	protein transport
LH22_RS04135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH22_RS04145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH22_RS04150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH22_RS04160	COG0203	ribosomal protein L17
LH22_RS04170	COG0789	Transcriptional regulator
LH22_RS04175	COG1970	mechanosensitive ion channel activity
LH22_RS04180	COG0569	domain protein
LH22_RS04185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH22_RS04185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH22_RS04190	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH22_RS04200	COG0758	DNA mediated transformation
LH22_RS04215	COG0009	L-threonylcarbamoyladenylate synthase
LH22_RS04220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH22_RS04230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LH22_RS04270	COG1126	abc transporter atp-binding protein
LH22_RS04275	COG0765	amino acid transport
LH22_RS04280	COG4597	amino acid ABC transporter
LH22_RS04285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS04290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LH22_RS04300	COG2264	protein methyltransferase activity
LH22_RS04305	COG4145	pantothenate transmembrane transporter activity
LH22_RS04310	COG3924	membrane
LH22_RS04315	COG0439	Biotin carboxylase
LH22_RS04320	COG0511	ligase activity, forming carbon-carbon bonds
LH22_RS04325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LH22_RS04335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH22_RS04340	COG2200	EAL domain
LH22_RS04340	COG2199	diguanylate cyclase activity
LH22_RS04345	COG1077	Cell shape determining protein MreB Mrl
LH22_RS04350	COG1792	Involved in formation and maintenance of cell shape
LH22_RS04355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LH22_RS04370	COG3164	Protein of unknown function
LH22_RS04375	COG0312	modulator of DNA gyrase
LH22_RS04380	COG0583	DNA-binding transcription factor activity
LH22_RS04390	COG1566	PFAM secretion protein HlyD family protein
LH22_RS04395	COG1289	transmembrane transporter activity
LH22_RS04405	COG2732	(Barnase) inhibitor
LH22_RS04425	COG1438	arginine binding
LH22_RS04430	COG0039	L-malate dehydrogenase activity
LH22_RS04435	COG1511	domain protein
LH22_RS04435	COG3264	Mechanosensitive ion channel
LH22_RS04440	COG0688	phosphatidylethanolamine metabolic process
LH22_RS04445	COG1162	GTPase activity
LH22_RS04450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LH22_RS04475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH22_RS04475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH22_RS04480	COG0802	atpase or kinase
LH22_RS04490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LH22_RS04495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH22_RS04500	COG1923	regulation of RNA biosynthetic process
LH22_RS04505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH22_RS04510	COG0330	HflC and HflK could
LH22_RS04515	COG0330	HflC and HflK could
LH22_RS04520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LH22_RS04525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH22_RS04535	COG0557	exoribonuclease II activity
LH22_RS04540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH22_RS04545	COG1960	acyl-CoA dehydrogenase activity
LH22_RS04555	COG0840	transmembrane signaling receptor activity
LH22_RS04560	COG1073	alpha beta
LH22_RS04580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LH22_RS04585	COG0359	binds to the 23S rRNA
LH22_RS04590	COG3061	Opacity-associated protein A
LH22_RS04595	COG0545	Peptidyl-prolyl cis-trans isomerase
LH22_RS04615	COG1218	3'(2'),5'-bisphosphate nucleotidase
LH22_RS04620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LH22_RS04630	COG1253	flavin adenine dinucleotide binding
LH22_RS04635	COG0729	surface antigen
LH22_RS04640	COG2911	Protein conserved in bacteria
LH22_RS04645	COG2105	PFAM AIG2 family protein
LH22_RS04650	COG3385	transposase activity
LH22_RS04660	COG2707	UPF0756 membrane protein
LH22_RS04680	COG3423	Transcriptional regulator
LH22_RS04685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH22_RS04690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH22_RS04695	COG3385	transposase activity
LH22_RS04700	COG3028	Belongs to the UPF0307 family
LH22_RS04705	COG0312	modulator of DNA gyrase
LH22_RS04710	COG3783	Cytochrome b(562)
LH22_RS04740	COG3964	amidohydrolase
LH22_RS04755	COG3711	transcriptional antiterminator
LH22_RS04755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS04760	COG0583	DNA-binding transcription factor activity
LH22_RS04765	COG1741	Belongs to the pirin family
LH22_RS04770	COG2823	Periplasmic or secreted lipoprotein
LH22_RS04775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH22_RS04780	COG0792	nuclease activity
LH22_RS04785	COG3107	peptidoglycan biosynthetic process
LH22_RS04790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH22_RS04805	COG0435	Glutathione S-transferase
LH22_RS04810	COG2259	Doxx family
LH22_RS04820	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LH22_RS04825	COG4575	ribosome binding
LH22_RS04830	COG1422	Protein of unknown function (DUF1090)
LH22_RS04840	COG0586	Pfam SNARE associated Golgi protein
LH22_RS04845	COG2186	Transcriptional regulator
LH22_RS04850	COG2271	Major facilitator Superfamily
LH22_RS04860	COG0246	Mannitol dehydrogenase
LH22_RS04865	COG2721	sulfolactate sulfo-lyase activity
LH22_RS04870	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LH22_RS04880	COG0673	inositol 2-dehydrogenase activity
LH22_RS04885	COG0038	chloride channel
LH22_RS04890	COG1451	nucleotide metabolic process
LH22_RS04895	COG2813	Specifically methylates the guanine in position
LH22_RS04900	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH22_RS04900	COG1902	pentaerythritol trinitrate reductase activity
LH22_RS04905	COG1063	alcohol dehydrogenase
LH22_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS04915	COG2610	gluconate transmembrane transporter activity
LH22_RS04925	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LH22_RS04930	COG0288	reversible hydration of carbon dioxide
LH22_RS04935	COG0659	secondary active sulfate transmembrane transporter activity
LH22_RS04940	COG2199	diguanylate cyclase activity
LH22_RS04945	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH22_RS04955	COG1285	pathogenesis
LH22_RS04965	COG3177	Filamentation induced by cAMP protein fic
LH22_RS04970	COG4974	Belongs to the 'phage' integrase family
LH22_RS05050	COG4695	Portal protein
LH22_RS05145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LH22_RS05190	COG4221	oxidoreductase activity
LH22_RS05210	COG3385	transposase activity
LH22_RS05220	COG0358	DNA primase activity
LH22_RS05225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH22_RS05240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LH22_RS05245	COG1968	undecaprenyl-diphosphatase activity
LH22_RS05250	COG0617	tRNA 3'-terminal CCA addition
LH22_RS05255	COG4991	sh3 domain protein
LH22_RS05260	COG3025	triphosphatase activity
LH22_RS05280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH22_RS05285	COG3384	dioxygenase
LH22_RS05290	COG0754	glutathionylspermidine amidase activity
LH22_RS05305	COG0494	nUDIX hydrolase
LH22_RS05310	COG3151	Protein conserved in bacteria
LH22_RS05315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH22_RS05320	COG3150	esterase
LH22_RS05325	COG0187	DNA topoisomerase II activity
LH22_RS05330	COG0583	DNA-binding transcription factor activity
LH22_RS05335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LH22_RS05340	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH22_RS05360	COG0191	fructose-bisphosphate aldolase activity
LH22_RS05365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS05365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS05370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS05370	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LH22_RS05370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS05380	COG3711	transcriptional antiterminator
LH22_RS05385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH22_RS05395	COG2132	Multicopper oxidase
LH22_RS05400	COG0656	L-ascorbic acid biosynthetic process
LH22_RS05405	COG2207	Transcriptional regulator
LH22_RS05410	COG0586	Pfam SNARE associated Golgi protein
LH22_RS05415	COG0626	cystathionine gamma-synthase activity
LH22_RS05425	COG0848	biopolymer transport protein
LH22_RS05470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH22_RS05480	COG4297	protein containing double-stranded beta helix domain
LH22_RS05485	COG2308	Evidence 4 Homologs of previously reported genes of
LH22_RS05495	COG1305	Transglutaminase-like
LH22_RS05510	COG3842	ATPase activity
LH22_RS05515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LH22_RS05520	COG1178	ABC-type Fe3 transport system permease component
LH22_RS05525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LH22_RS05530	COG5001	Diguanylate cyclase
LH22_RS05530	COG3300	MHYT domain
LH22_RS05535	COG1528	Iron-storage protein
LH22_RS05540	COG1473	amidohydrolase
LH22_RS05550	COG2823	Periplasmic or secreted lipoprotein
LH22_RS05555	COG4667	esterase of the alpha-beta hydrolase superfamily
LH22_RS05560	COG0084	hydrolase, TatD family'
LH22_RS05565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LH22_RS05575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LH22_RS05590	COG3706	GGDEF domain
LH22_RS05625	COG1017	nitric oxide dioxygenase activity
LH22_RS05625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH22_RS05630	COG0625	glutathione transferase activity
LH22_RS05635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH22_RS05640	COG1486	melibiose metabolic process
LH22_RS05645	COG1447	Phosphotransferase system cellobiose-specific component IIA
LH22_RS05680	COG3121	Chaperone
LH22_RS05685	COG3188	usher protein
LH22_RS05730	COG1609	Transcriptional regulator
LH22_RS05735	COG0673	inositol 2-dehydrogenase activity
LH22_RS05755	COG2072	flavoprotein involved in K transport
LH22_RS05770	COG1126	abc transporter atp-binding protein
LH22_RS05775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS05780	COG0765	amino acid transport
LH22_RS05785	COG0765	amino acid transport
LH22_RS05805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH22_RS05810	COG1312	Catalyzes the dehydration of D-mannonate
LH22_RS05820	COG2199	diguanylate cyclase activity
LH22_RS05835	COG0583	DNA-binding transcription factor activity
LH22_RS05855	COG0702	epimerase
LH22_RS05860	COG1733	regulation of RNA biosynthetic process
LH22_RS05865	COG2271	Major facilitator Superfamily
LH22_RS05880	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS05890	COG1271	oxidase subunit
LH22_RS05895	COG1294	oxidase, subunit
LH22_RS05900	COG2207	Transcriptional regulator
LH22_RS05900	COG3708	Transcriptional regulator
LH22_RS05910	COG2375	cellular response to nickel ion
LH22_RS05915	COG1695	Transcriptional regulator
LH22_RS05930	COG3720	iron ion transport
LH22_RS05935	COG4558	Periplasmic binding protein
LH22_RS05940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH22_RS05945	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LH22_RS05950	COG0604	alcohol dehydrogenase
LH22_RS05955	COG1982	Orn Lys Arg decarboxylase major
LH22_RS05960	COG0741	lytic transglycosylase activity
LH22_RS05970	COG1194	a g-specific adenine glycosylase
LH22_RS05980	COG3171	Protein conserved in bacteria
LH22_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH22_RS05995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH22_RS06000	COG0762	integral membrane protein
LH22_RS06005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH22_RS06010	COG2805	Type II/IV secretion system protein
LH22_RS06020	COG1678	Uncharacterized ACR, COG1678
LH22_RS06030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH22_RS06035	COG2356	endonuclease I
LH22_RS06045	COG2814	Major facilitator Superfamily
LH22_RS06060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH22_RS06065	COG1166	arginine decarboxylase activity
LH22_RS06150	COG1216	Glycosyl transferase, family 2
LH22_RS06150	COG0438	transferase activity, transferring glycosyl groups
LH22_RS06165	COG1091	dTDP-4-dehydrorhamnose reductase activity
LH22_RS06195	COG3753	Protein conserved in bacteria
LH22_RS06200	COG0501	Belongs to the peptidase M48B family
LH22_RS06205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH22_RS06210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH22_RS06215	COG0126	phosphoglycerate kinase activity
LH22_RS06220	COG0191	fructose-bisphosphate aldolase activity
LH22_RS06225	COG0668	transmembrane transport
LH22_RS06230	COG1279	arginine transmembrane transporter activity
LH22_RS06245	COG2271	Major facilitator Superfamily
LH22_RS06250	COG2968	Membrane
LH22_RS06255	COG0583	DNA-binding transcription factor activity
LH22_RS06265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH22_RS06270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH22_RS06280	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LH22_RS06285	COG3079	Belongs to the UPF0149 family
LH22_RS06290	COG0006	proline dipeptidase activity
LH22_RS06295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH22_RS06300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH22_RS06315	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH22_RS06315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH22_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS06325	COG1272	protein, Hemolysin III
LH22_RS06330	COG0354	folic acid binding
LH22_RS06345	COG0716	FMN binding
LH22_RS06350	COG4974	Belongs to the 'phage' integrase family
LH22_RS06355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH22_RS06360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH22_RS06365	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH22_RS06370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH22_RS06395	COG0765	amino acid transport
LH22_RS06400	COG4215	(ABC) transporter
LH22_RS06415	COG3121	Chaperone
LH22_RS06430	COG3121	Chaperone
LH22_RS06450	COG2814	Major facilitator Superfamily
LH22_RS06455	COG0583	DNA-binding transcription factor activity
LH22_RS06470	COG1609	Transcriptional regulator
LH22_RS06480	COG0768	penicillin binding
LH22_RS06525	COG0204	Acyl-transferase
LH22_RS06525	COG0318	PFAM AMP-dependent synthetase and ligase
LH22_RS06535	COG0667	Aldo Keto reductase
LH22_RS06545	COG0861	Integral membrane protein TerC family
LH22_RS06555	COG1051	belongs to the nudix hydrolase family
LH22_RS06565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LH22_RS06570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LH22_RS06580	COG4795	General secretion pathway protein
LH22_RS06595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LH22_RS06605	COG1074	ATP-dependent DNA helicase activity
LH22_RS06610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LH22_RS06615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH22_RS06615	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LH22_RS06620	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH22_RS06640	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LH22_RS06645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LH22_RS06650	COG2166	iron-sulfur cluster assembly
LH22_RS06655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH22_RS06665	COG0583	DNA-binding transcription factor activity
LH22_RS06670	COG2363	Small membrane protein
LH22_RS06685	COG1611	Belongs to the LOG family
LH22_RS06690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH22_RS06690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH22_RS06700	COG3098	single-species biofilm formation
LH22_RS06705	COG0564	pseudouridine synthase activity
LH22_RS06715	COG2721	sulfolactate sulfo-lyase activity
LH22_RS06720	COG2271	Major facilitator Superfamily
LH22_RS06725	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS06730	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS06740	COG2084	Dehydrogenase
LH22_RS06745	COG1929	Belongs to the glycerate kinase type-1 family
LH22_RS06755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH22_RS06760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH22_RS06765	COG3956	TIGRFAM MazG family protein
LH22_RS06770	COG0504	CTP synthase activity
LH22_RS06775	COG0148	phosphopyruvate hydratase activity
LH22_RS06780	COG0602	queuosine metabolic process
LH22_RS06785	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH22_RS06790	COG0720	synthase
LH22_RS06800	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH22_RS06815	COG2234	aminopeptidase activity
LH22_RS06820	COG1648	precorrin-2 dehydrogenase activity
LH22_RS06820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH22_RS06825	COG0175	sulfate reduction
LH22_RS06830	COG2895	sulfate adenylyltransferase (ATP) activity
LH22_RS06845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LH22_RS06860	COG0585	pseudouridine synthase activity
LH22_RS06865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LH22_RS06870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH22_RS06875	COG1388	LysM domain
LH22_RS06875	COG4942	peptidase
LH22_RS06880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH22_RS06885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH22_RS06905	COG0582	viral genome integration into host DNA
LH22_RS07010	COG2951	lytic endotransglycosylase activity
LH22_RS07015	COG2824	Alkylphosphonate utilization operon protein PhnA
LH22_RS07020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH22_RS07025	COG4106	trans-aconitate 2-methyltransferase activity
LH22_RS07030	COG1546	Belongs to the CinA family
LH22_RS07050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LH22_RS07080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH22_RS07085	COG1238	metal cluster binding
LH22_RS07090	COG2918	glutathione biosynthetic process
LH22_RS07095	COG1854	S-ribosylhomocysteine lyase activity
LH22_RS07100	COG4536	flavin adenine dinucleotide binding
LH22_RS07105	COG4137	Cytochrome C assembly protein
LH22_RS07110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH22_RS07115	COG0228	four-way junction DNA binding
LH22_RS07130	COG0335	large ribosomal subunit rRNA binding
LH22_RS07140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH22_RS07145	COG0287	Prephenate dehydrogenase
LH22_RS07145	COG1605	Chorismate mutase
LH22_RS07150	COG1605	Chorismate mutase
LH22_RS07150	COG0077	Prephenate dehydratase
LH22_RS07155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH22_RS07160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS07165	COG0564	pseudouridine synthase activity
LH22_RS07175	COG0542	response to heat
LH22_RS07205	COG0477	Major facilitator Superfamily
LH22_RS07210	COG5544	Lipoprotein
LH22_RS07215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH22_RS07220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH22_RS07220	COG1042	CoA-binding domain protein
LH22_RS07220	COG0045	succinate-CoA ligase (ADP-forming) activity
LH22_RS07225	COG0791	NLP P60 protein
LH22_RS07230	COG3148	PFAM DTW domain containing protein
LH22_RS07235	COG3118	belongs to the thioredoxin family
LH22_RS07240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH22_RS07245	COG2814	Major facilitator Superfamily
LH22_RS07250	COG1566	PFAM secretion protein HlyD family protein
LH22_RS07255	COG1846	Transcriptional regulator
LH22_RS07275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH22_RS07280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH22_RS07285	COG1780	Probably involved in ribonucleotide reductase function
LH22_RS07290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH22_RS07295	COG4575	ribosome binding
LH22_RS07305	COG0833	amino acid
LH22_RS07310	COG2040	homocysteine
LH22_RS07320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH22_RS07330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH22_RS07335	COG1116	anion transmembrane transporter activity
LH22_RS07340	COG4608	Belongs to the ABC transporter superfamily
LH22_RS07345	COG0444	Belongs to the ABC transporter superfamily
LH22_RS07350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS07355	COG0601	transmembrane transport
LH22_RS07360	COG0747	negative chemotaxis
LH22_RS07375	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH22_RS07445	COG0582	viral genome integration into host DNA
LH22_RS07455	COG2867	negative regulation of translational initiation
LH22_RS07465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS07470	COG0497	DNA recombination
LH22_RS07475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH22_RS07480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH22_RS07495	COG0513	Belongs to the DEAD box helicase family
LH22_RS07500	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH22_RS07505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH22_RS07520	COG3026	antisigma factor binding
LH22_RS07525	COG3086	response to oxidative stress
LH22_RS07530	COG0481	GTPase activity
LH22_RS07540	COG0571	ribonuclease III activity
LH22_RS07550	COG1381	Involved in DNA repair and RecF pathway recombination
LH22_RS07555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH22_RS07560	COG0736	holo-[acyl-carrier-protein] synthase activity
LH22_RS07565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH22_RS07575	COG1737	Transcriptional regulator
LH22_RS07580	COG0560	Phosphoserine phosphatase
LH22_RS07590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LH22_RS07595	COG0047	phosphoribosylformylglycinamidine synthase activity
LH22_RS07595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH22_RS07605	COG2205	protein histidine kinase activity
LH22_RS07610	COG3170	Tfp pilus assembly protein FimV
LH22_RS07615	COG2204	response regulator
LH22_RS07620	COG0347	Belongs to the P(II) protein family
LH22_RS07625	COG1017	nitric oxide dioxygenase activity
LH22_RS07625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH22_RS07630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH22_RS07635	COG2814	Major facilitator Superfamily
LH22_RS07640	COG3711	transcriptional antiterminator
LH22_RS07650	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LH22_RS07655	COG0483	inositol monophosphate 1-phosphatase activity
LH22_RS07665	COG1959	2 iron, 2 sulfur cluster binding
LH22_RS07675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH22_RS07685	COG2897	thiosulfate sulfurtransferase activity
LH22_RS07690	COG2373	Large extracellular alpha-helical protein
LH22_RS07695	COG4953	penicillin-binding protein 1C
LH22_RS07700	COG0105	UTP biosynthetic process
LH22_RS07705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH22_RS07715	COG1426	Protein conserved in bacteria
LH22_RS07720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH22_RS07725	COG0124	histidyl-tRNA synthetase
LH22_RS07730	COG2976	Protein conserved in bacteria
LH22_RS07735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS07740	COG1160	GTP binding
LH22_RS07745	COG4993	Dehydrogenase
LH22_RS07760	COG1570	exodeoxyribonuclease VII activity
LH22_RS07765	COG0516	GMP reductase activity
LH22_RS07765	COG0517	IMP dehydrogenase activity
LH22_RS07770	COG0519	Catalyzes the synthesis of GMP from XMP
LH22_RS07770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH22_RS07810	COG2239	Acts as a magnesium transporter
LH22_RS07820	COG0500	methyltransferase
LH22_RS07830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LH22_RS07835	COG0573	inorganic phosphate transmembrane transporter activity
LH22_RS07845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH22_RS07850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH22_RS07855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH22_RS07860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LH22_RS07865	COG2233	PERMEase
LH22_RS07870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH22_RS07875	COG1393	Belongs to the ArsC family
LH22_RS07880	COG4783	chaperone-mediated protein folding
LH22_RS07895	COG1609	Transcriptional regulator
LH22_RS07910	COG4208	sulfate ABC transporter
LH22_RS07915	COG3842	ATPase activity
LH22_RS07920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH22_RS07935	COG0628	permease
LH22_RS07940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH22_RS07945	COG2716	regulation of RNA biosynthetic process
LH22_RS07950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH22_RS07955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LH22_RS07965	COG2321	neutral zinc metallopeptidase
LH22_RS07975	COG0400	carboxylic ester hydrolase activity
LH22_RS07985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH22_RS07990	COG1393	Belongs to the ArsC family
LH22_RS08000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH22_RS08005	COG2197	response regulator
LH22_RS08010	COG3850	Histidine kinase
LH22_RS08025	COG3062	negative regulation of establishment of protein localization
LH22_RS08030	COG0243	molybdopterin cofactor binding
LH22_RS08035	COG3043	anaerobic respiration
LH22_RS08040	COG3005	denitrification pathway
LH22_RS08045	COG0494	nUDIX hydrolase
LH22_RS08050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS08055	COG1940	carbohydrate kinase activity
LH22_RS08060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH22_RS08070	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS08075	COG1129	ABC transporter
LH22_RS08085	COG1349	DNA-binding transcription factor activity
LH22_RS08090	COG5342	invasion associated locus B
LH22_RS08095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH22_RS08100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH22_RS08105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH22_RS08115	COG0408	coproporphyrinogen oxidase activity
LH22_RS08125	COG0456	acetyltransferase
LH22_RS08140	COG2837	iron assimilation
LH22_RS08150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LH22_RS08155	COG4208	sulfate ABC transporter
LH22_RS08160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH22_RS08165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LH22_RS08170	COG0745	RESPONSE REGULATOR receiver
LH22_RS08175	COG2205	protein histidine kinase activity
LH22_RS08205	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LH22_RS08210	COG3115	cell septum assembly
LH22_RS08220	COG3530	Putative quorum-sensing-regulated virulence factor
LH22_RS08225	COG0385	Bile acid
LH22_RS08230	COG0583	DNA-binding transcription factor activity
LH22_RS08260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH22_RS08265	COG3415	Transposase
LH22_RS08270	COG2116	formate transmembrane transporter activity
LH22_RS08300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS08305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH22_RS08310	COG1914	H( )-stimulated, divalent metal cation uptake system
LH22_RS08320	COG0667	Aldo Keto reductase
LH22_RS08325	COG3961	Belongs to the TPP enzyme family
LH22_RS08330	COG0837	glucose binding
LH22_RS08335	COG3279	Response regulator of the LytR AlgR family
LH22_RS08340	COG3275	phosphorelay sensor kinase activity
LH22_RS08355	COG0436	Aminotransferase
LH22_RS08395	COG2223	nitrite transmembrane transporter activity
LH22_RS08425	COG2116	formate transmembrane transporter activity
LH22_RS08435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH22_RS08440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH22_RS08445	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH22_RS08450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH22_RS08455	COG1138	Cytochrome C-type biogenesis protein
LH22_RS08470	COG3088	subunit of a heme lyase
LH22_RS08470	COG4235	cytochrome complex assembly
LH22_RS08480	COG2067	long-chain fatty acid transport protein
LH22_RS08485	COG3691	Protein conserved in bacteria
LH22_RS08490	COG0183	Belongs to the thiolase family
LH22_RS08495	COG1024	Enoyl-CoA hydratase
LH22_RS08495	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH22_RS08500	COG2062	phosphohistidine phosphatase, SixA
LH22_RS08515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH22_RS08525	COG0730	response to heat
LH22_RS08530	COG3101	peptidyl-lysine hydroxylation
LH22_RS08545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH22_RS08580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH22_RS08585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH22_RS08595	COG0586	Pfam SNARE associated Golgi protein
LH22_RS08605	COG0285	dihydrofolate synthase activity
LH22_RS08610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LH22_RS08615	COG1286	toxin biosynthetic process
LH22_RS08620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LH22_RS08625	COG0163	prenyltransferase activity
LH22_RS08640	COG4160	amino acid transport
LH22_RS08645	COG4598	ABC transporter
LH22_RS08655	COG0246	Mannitol dehydrogenase
LH22_RS08660	COG1070	Carbohydrate kinase
LH22_RS08670	COG1090	epimerase
LH22_RS08675	COG0625	glutathione transferase activity
LH22_RS08685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH22_RS08690	COG0280	phosphate acetyltransferase
LH22_RS08690	COG0857	belongs to the CobB CobQ family
LH22_RS08695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH22_RS08700	COG3092	negative regulation of chromosome organization
LH22_RS08710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH22_RS08715	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LH22_RS08720	COG0436	Aminotransferase
LH22_RS08725	COG0583	DNA-binding transcription factor activity
LH22_RS08740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH22_RS08740	COG0649	NAD binding
LH22_RS08760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH22_RS08770	COG0839	Belongs to the complex I subunit 6 family
LH22_RS08775	COG0713	ATP synthesis coupled electron transport
LH22_RS08780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH22_RS08785	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH22_RS08790	COG1007	ATP synthesis coupled electron transport
LH22_RS08795	COG2153	protein acetylation
LH22_RS08805	COG4575	ribosome binding
LH22_RS08815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH22_RS08820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH22_RS08825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH22_RS08830	COG1070	Carbohydrate kinase
LH22_RS08835	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LH22_RS08840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH22_RS08850	COG2205	protein histidine kinase activity
LH22_RS08850	COG0784	Response regulator, receiver
LH22_RS08855	COG2197	response regulator
LH22_RS08860	COG2198	Histidine kinase
LH22_RS08860	COG0642	Histidine kinase
LH22_RS08865	COG2223	nitrite transmembrane transporter activity
LH22_RS08875	COG1132	(ABC) transporter
LH22_RS08880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH22_RS08910	COG4615	Cyclic peptide transporter
LH22_RS08955	COG1061	Type III restriction enzyme res subunit
LH22_RS08960	COG1187	pseudouridine synthase activity
LH22_RS08965	COG2814	Major facilitator Superfamily
LH22_RS08975	COG4172	Belongs to the ABC transporter superfamily
LH22_RS08980	COG4239	(ABC) transporter, permease
LH22_RS08985	COG4174	ABC transporter (Permease)
LH22_RS08990	COG4166	transmembrane transport
LH22_RS08995	COG2200	EAL domain
LH22_RS09000	COG0791	NLP P60 protein
LH22_RS09005	COG0671	phosphoesterase, PA-phosphatase related
LH22_RS09010	COG0523	cobalamin synthesis protein
LH22_RS09015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH22_RS09030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS09030	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS09035	COG1105	Belongs to the carbohydrate kinase PfkB family
LH22_RS09040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LH22_RS09040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS09040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH22_RS09045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LH22_RS09060	COG0583	DNA-binding transcription factor activity
LH22_RS09065	COG0833	amino acid
LH22_RS09070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH22_RS09075	COG1120	ATPase activity
LH22_RS09090	COG0583	DNA-binding transcription factor activity
LH22_RS09095	COG0477	Major facilitator Superfamily
LH22_RS09105	COG2311	Membrane
LH22_RS09130	COG2949	membrane
LH22_RS09135	COG0281	malic enzyme
LH22_RS09140	COG0295	cytidine deaminase activity
LH22_RS09145	COG1346	cytolysis
LH22_RS09150	COG1380	Effector of murein hydrolase LrgA
LH22_RS09155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH22_RS09155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH22_RS09160	COG0489	protein tyrosine kinase activity
LH22_RS09195	COG1830	Aldolase
LH22_RS09200	COG1802	Transcriptional regulator
LH22_RS09205	COG0246	Mannitol dehydrogenase
LH22_RS09210	COG2271	Major facilitator Superfamily
LH22_RS09215	COG1063	alcohol dehydrogenase
LH22_RS09225	COG0673	inositol 2-dehydrogenase activity
LH22_RS09230	COG1597	lipid kinase activity
LH22_RS09235	COG0826	peptidase U32
LH22_RS09240	COG0745	RESPONSE REGULATOR receiver
LH22_RS09245	COG2205	protein histidine kinase activity
LH22_RS09250	COG0477	Major facilitator Superfamily
LH22_RS09255	COG1487	ribonuclease activity
LH22_RS09265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH22_RS09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH22_RS09285	COG0667	Aldo Keto reductase
LH22_RS09295	COG0443	Heat shock 70 kDa protein
LH22_RS09300	COG5001	Diguanylate cyclase
LH22_RS09300	COG3447	MASE1 domain protein
LH22_RS09300	COG5002	protein histidine kinase activity
LH22_RS09310	COG0572	uridine kinase
LH22_RS09315	COG0717	Belongs to the dCTP deaminase family
LH22_RS09320	COG2982	Protein involved in outer membrane biogenesis
LH22_RS09325	COG1253	flavin adenine dinucleotide binding
LH22_RS09370	COG1216	Glycosyl transferase, family 2
LH22_RS09410	COG2755	lipolytic protein G-D-S-L family
LH22_RS09410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH22_RS09415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LH22_RS09420	COG1088	dTDP-glucose 4,6-dehydratase activity
LH22_RS09435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH22_RS09450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH22_RS09485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LH22_RS09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS09500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LH22_RS09500	COG0140	phosphoribosyl-ATP diphosphatase activity
LH22_RS09510	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH22_RS09525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH22_RS09535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH22_RS09540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH22_RS09545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH22_RS09550	COG1917	Cupin 2, conserved barrel domain protein
LH22_RS09550	COG1396	sequence-specific DNA binding
LH22_RS09555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LH22_RS09560	COG0174	glutamine synthetase
LH22_RS09565	COG0531	amino acid
LH22_RS09570	COG1349	DNA-binding transcription factor activity
LH22_RS09575	COG2084	Dehydrogenase
LH22_RS09580	COG3395	kinase activity
LH22_RS09585	COG0235	Class ii aldolase
LH22_RS09590	COG3622	Belongs to the hyi family
LH22_RS09595	COG2610	gluconate transmembrane transporter activity
LH22_RS09600	COG2925	Exonuclease
LH22_RS09610	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LH22_RS09615	COG1289	transmembrane transporter activity
LH22_RS09620	COG2926	Belongs to the UPF0265 family
LH22_RS09625	COG1609	Transcriptional regulator
LH22_RS09630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LH22_RS09635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH22_RS09640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH22_RS09650	COG0454	-acetyltransferase
LH22_RS09655	COG0747	negative chemotaxis
LH22_RS09665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS09670	COG4172	Belongs to the ABC transporter superfamily
LH22_RS09675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS09690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS09700	COG1598	PFAM Uncharacterised protein family UPF0150
LH22_RS09730	COG2011	ABC-type metal ion transport system permease component
LH22_RS09740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS09880	COG0515	serine threonine protein kinase
LH22_RS09895	COG3209	COG3209 Rhs family protein
LH22_RS09925	COG4104	PAAR repeat-containing protein
LH22_RS09925	COG3209	COG3209 Rhs family protein
LH22_RS09955	COG1129	ABC transporter
LH22_RS09960	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS09970	COG0583	DNA-binding transcription factor activity
LH22_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
LH22_RS09990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH22_RS10000	COG0601	transmembrane transport
LH22_RS10005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS10020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH22_RS10025	COG1473	amidohydrolase
LH22_RS10035	COG1522	sequence-specific DNA binding
LH22_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS10060	COG5001	Diguanylate cyclase
LH22_RS10065	COG2188	Transcriptional regulator
LH22_RS10070	COG3624	Phosphonate C-P lyase system protein PhnG
LH22_RS10075	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LH22_RS10080	COG3626	phosphonate metabolism
LH22_RS10085	COG3627	carbon phosphorus lyase activity
LH22_RS10090	COG4107	phosphonate C-P lyase system protein PhnK
LH22_RS10095	COG4778	phosphonate C-P lyase system protein PhnL
LH22_RS10100	COG3454	Phosphonate metabolism
LH22_RS10105	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH22_RS10110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH22_RS10120	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH22_RS10130	COG3639	organic phosphonate transmembrane transporter activity
LH22_RS10140	COG1129	ABC transporter
LH22_RS10145	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS10160	COG0191	fructose-bisphosphate aldolase activity
LH22_RS10175	COG2252	PERMEase
LH22_RS10190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH22_RS10220	COG0534	Mate efflux family protein
LH22_RS10225	COG4774	siderophore transport
LH22_RS10250	COG1418	mRNA catabolic process
LH22_RS10260	COG0840	transmembrane signaling receptor activity
LH22_RS10265	COG0270	DNA (cytosine-5-)-methyltransferase activity
LH22_RS10270	COG3727	T/G mismatch-specific endonuclease activity
LH22_RS10280	COG2354	Protein conserved in bacteria
LH22_RS10285	COG5475	Uncharacterized small protein (DUF2158)
LH22_RS10295	COG1215	transferase activity, transferring glycosyl groups
LH22_RS10325	COG0840	transmembrane signaling receptor activity
LH22_RS10340	COG1987	bacterial-type flagellum assembly
LH22_RS10345	COG1338	Plays a role in the flagellum-specific transport system
LH22_RS10355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH22_RS10365	COG1580	Controls the rotational direction of flagella during chemotaxis
LH22_RS10375	COG2882	bacterial-type flagellum organization
LH22_RS10385	COG1317	bacterial-type flagellum organization
LH22_RS10390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH22_RS10395	COG1766	The M ring may be actively involved in energy transduction
LH22_RS10400	COG1677	Flagellar hook-basal body complex protein FliE
LH22_RS10410	COG2200	EAL domain
LH22_RS10470	COG1516	flagellar protein fliS
LH22_RS10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS10515	COG0765	amino acid transport
LH22_RS10520	COG1126	abc transporter atp-binding protein
LH22_RS10525	COG4763	Acyl-transferase
LH22_RS10530	COG4763	Acyl-transferase
LH22_RS10535	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH22_RS10535	COG0506	proline dehydrogenase activity
LH22_RS10535	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH22_RS10540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH22_RS10560	COG1702	phosphate starvation-inducible protein PhoH
LH22_RS10575	COG0583	DNA-binding transcription factor activity
LH22_RS10590	COG3385	transposase activity
LH22_RS10600	COG4977	sequence-specific DNA binding
LH22_RS10610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH22_RS10615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH22_RS10620	COG1447	Phosphotransferase system cellobiose-specific component IIA
LH22_RS10625	COG2723	6-phospho-beta-galactosidase activity
LH22_RS10630	COG1486	melibiose metabolic process
LH22_RS10635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH22_RS10645	COG0012	GTP binding
LH22_RS10650	COG0193	aminoacyl-tRNA hydrolase activity
LH22_RS10660	COG3706	GGDEF domain
LH22_RS10675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LH22_RS10700	COG2912	Transglutaminase-like superfamily
LH22_RS10705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH22_RS10710	COG3385	transposase activity
LH22_RS10715	COG0387	Pfam Sodium calcium exchanger
LH22_RS10720	COG4572	Cation transport regulator
LH22_RS10725	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LH22_RS10730	COG0515	serine threonine protein kinase
LH22_RS10770	COG3707	response regulator
LH22_RS10775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH22_RS10785	COG1116	anion transmembrane transporter activity
LH22_RS10790	COG2146	nitrite reductase [NAD(P)H] activity
LH22_RS10790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH22_RS10795	COG0243	molybdopterin cofactor binding
LH22_RS10800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH22_RS10800	COG1648	precorrin-2 dehydrogenase activity
LH22_RS10820	COG0018	arginyl-trna synthetase
LH22_RS10825	COG3102	Protein conserved in bacteria
LH22_RS10835	COG3142	Participates in the control of copper homeostasis
LH22_RS10845	COG1280	lysine exporter protein (LysE YggA)
LH22_RS10850	COG0500	methyltransferase
LH22_RS10855	COG2226	methyltransferase
LH22_RS10860	COG1801	Protein of unknown function DUF72
LH22_RS10870	COG0494	nUDIX hydrolase
LH22_RS10875	COG0217	transcriptional regulatory protein
LH22_RS10880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LH22_RS10885	COG0632	four-way junction helicase activity
LH22_RS10890	COG2255	four-way junction helicase activity
LH22_RS10895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH22_RS10905	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LH22_RS10910	COG0739	heme binding
LH22_RS10915	COG1560	Kdo2-lipid A biosynthetic process
LH22_RS10925	COG0469	pyruvate kinase activity
LH22_RS10930	COG1737	Transcriptional regulator
LH22_RS10935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH22_RS10940	COG0800	Aldolase
LH22_RS10945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LH22_RS10950	COG2979	Protein of unknown function (DUF533)
LH22_RS10955	COG1770	oligopeptidase
LH22_RS10960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH22_RS10970	COG2372	response to copper ion
LH22_RS10975	COG1276	copper resistance
LH22_RS11040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH22_RS11050	COG3008	intermembrane lipid transfer
LH22_RS11055	COG2995	paraquat-inducible protein a
LH22_RS11060	COG1956	GAF domain-containing protein
LH22_RS11065	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LH22_RS11070	COG0793	Belongs to the peptidase S41A family
LH22_RS11075	COG0501	Belongs to the peptidase M48B family
LH22_RS11080	COG2814	Major facilitator Superfamily
LH22_RS11110	COG2226	methyltransferase
LH22_RS11120	COG3716	PTS system mannose fructose sorbose family IID component
LH22_RS11125	COG3715	PTS system
LH22_RS11130	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS11130	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS11135	COG1253	flavin adenine dinucleotide binding
LH22_RS11140	COG2200	EAL domain
LH22_RS11145	COG1760	l-serine dehydratase
LH22_RS11150	COG0494	nUDIX hydrolase
LH22_RS11165	COG0251	oxidation-reduction process
LH22_RS11170	COG1199	ATP-dependent helicase activity
LH22_RS11180	COG3065	identical protein binding
LH22_RS11185	COG0318	PFAM AMP-dependent synthetase and ligase
LH22_RS11190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH22_RS11195	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LH22_RS11200	COG2894	cell division
LH22_RS11205	COG0850	regulation of cytokinetic process
LH22_RS11210	COG3100	YcgL domain-containing protein
LH22_RS11215	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH22_RS11230	COG2186	Transcriptional regulator
LH22_RS11235	COG2719	SpoVR family
LH22_RS11240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH22_RS11245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH22_RS11270	COG2718	Belongs to the UPF0229 family
LH22_RS11275	COG2766	serine protein kinase
LH22_RS11280	COG3713	MltA-interacting MipA family protein
LH22_RS11285	COG0656	L-ascorbic acid biosynthetic process
LH22_RS11300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH22_RS11305	COG3139	Protein of unknown function (DUF1315)
LH22_RS11310	COG1335	isochorismatase
LH22_RS11315	COG0252	asparaginase activity
LH22_RS11325	COG0778	Nitroreductase
LH22_RS11335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH22_RS11345	COG0708	Exodeoxyribonuclease III
LH22_RS11360	COG0788	formyltetrahydrofolate deformylase activity
LH22_RS11365	COG3012	SEC-C Motif Domain Protein
LH22_RS11370	COG1752	Esterase of the alpha-beta hydrolase superfamily
LH22_RS11375	COG0745	RESPONSE REGULATOR receiver
LH22_RS11380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH22_RS11395	COG2916	Histone family protein nucleoid-structuring protein H-NS
LH22_RS11405	COG1454	alcohol dehydrogenase
LH22_RS11405	COG1012	belongs to the aldehyde dehydrogenase family
LH22_RS11410	COG2095	MarC family integral membrane protein
LH22_RS11425	COG0601	transmembrane transport
LH22_RS11430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS11445	COG3099	Belongs to the UPF0263 family
LH22_RS11450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH22_RS11460	COG2350	Protein conserved in bacteria
LH22_RS11475	COG2917	probably involved in intracellular septation
LH22_RS11485	COG3047	cAMP biosynthetic process
LH22_RS11490	COG2823	Periplasmic or secreted lipoprotein
LH22_RS11505	COG0133	tryptophan synthase activity
LH22_RS11515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH22_RS11520	COG0512	Glutamine amidotransferase of anthranilate synthase
LH22_RS11520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH22_RS11525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LH22_RS11530	COG0613	PHP domain protein
LH22_RS11535	COG0009	L-threonylcarbamoyladenylate synthase
LH22_RS11550	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LH22_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS11560	COG0616	signal peptide processing
LH22_RS11595	COG0671	phosphoesterase, PA-phosphatase related
LH22_RS11600	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LH22_RS11605	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LH22_RS11615	COG0023	Translation Initiation Factor
LH22_RS11635	COG1024	Enoyl-CoA hydratase
LH22_RS11640	COG5001	Diguanylate cyclase
LH22_RS11650	COG1966	Carbon starvation protein
LH22_RS11655	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LH22_RS11660	COG0243	molybdopterin cofactor binding
LH22_RS11665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS11665	COG1263	PTS System
LH22_RS11675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH22_RS11675	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH22_RS11680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH22_RS11695	COG4171	peptide transport system, permease
LH22_RS11705	COG4166	transmembrane transport
LH22_RS11715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LH22_RS11720	COG1842	Phage shock protein A
LH22_RS11730	COG1983	PspC domain protein
LH22_RS11740	COG3106	COG3106 Predicted ATPase
LH22_RS11745	COG3768	UPF0283 membrane protein
LH22_RS11755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LH22_RS11760	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS11765	COG2866	Carboxypeptidase
LH22_RS11770	COG4166	transmembrane transport
LH22_RS11815	COG2200	EAL domain
LH22_RS11895	COG0840	transmembrane signaling receptor activity
LH22_RS11910	COG0366	Alpha amylase catalytic
LH22_RS11945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH22_RS11965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LH22_RS11965	COG0674	pyruvate-flavodoxin oxidoreductase activity
LH22_RS11965	COG1013	pyruvate-flavodoxin oxidoreductase activity
LH22_RS11965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH22_RS11970	COG1285	pathogenesis
LH22_RS11980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH22_RS11985	COG2911	Protein conserved in bacteria
LH22_RS11995	COG3784	Protein of unknown function (DUF1318)
LH22_RS12005	COG1643	Atp-dependent helicase
LH22_RS12010	COG3591	Belongs to the peptidase S1B family
LH22_RS12020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LH22_RS12025	COG2205	protein histidine kinase activity
LH22_RS12030	COG0745	RESPONSE REGULATOR receiver
LH22_RS12040	COG0531	amino acid
LH22_RS12050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LH22_RS12055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LH22_RS12065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH22_RS12070	COG2840	Smr protein MutS2
LH22_RS12075	COG0583	DNA-binding transcription factor activity
LH22_RS12085	COG5383	Protein conserved in bacteria
LH22_RS12095	COG2272	Belongs to the type-B carboxylesterase lipase family
LH22_RS12100	COG0840	transmembrane signaling receptor activity
LH22_RS12105	COG0583	DNA-binding transcription factor activity
LH22_RS12110	COG0436	Aminotransferase
LH22_RS12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS12120	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH22_RS12125	COG0747	negative chemotaxis
LH22_RS12130	COG0583	DNA-binding transcription factor activity
LH22_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
LH22_RS12190	COG1309	transcriptional regulator
LH22_RS12200	COG2814	Major facilitator Superfamily
LH22_RS12210	COG2814	Major facilitator Superfamily
LH22_RS12215	COG0583	DNA-binding transcription factor activity
LH22_RS12220	COG1940	carbohydrate kinase activity
LH22_RS12225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH22_RS12230	COG2233	PERMEase
LH22_RS12255	COG0477	Major facilitator Superfamily
LH22_RS12260	COG3385	transposase activity
LH22_RS12280	COG4221	oxidoreductase activity
LH22_RS12285	COG0582	viral genome integration into host DNA
LH22_RS12305	COG0402	S-adenosylhomocysteine deaminase activity
LH22_RS12315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH22_RS12325	COG0339	signal peptide processing
LH22_RS12340	COG0671	phosphoesterase, PA-phosphatase related
LH22_RS12350	COG1070	Carbohydrate kinase
LH22_RS12360	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH22_RS12380	COG0346	lactoylglutathione lyase activity
LH22_RS12405	COG1349	DNA-binding transcription factor activity
LH22_RS12440	COG1129	ABC transporter
LH22_RS12445	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS12450	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS12455	COG1349	DNA-binding transcription factor activity
LH22_RS12460	COG0753	catalase activity
LH22_RS12485	COG0402	S-adenosylhomocysteine deaminase activity
LH22_RS12500	COG0583	DNA-binding transcription factor activity
LH22_RS12505	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LH22_RS12510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH22_RS12515	COG2828	Protein conserved in bacteria
LH22_RS12530	COG4988	ABC transporter
LH22_RS12535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH22_RS12555	COG4628	conserved protein (DUF2132)
LH22_RS12560	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LH22_RS12580	COG2706	6-phosphogluconolactonase activity
LH22_RS12585	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS12595	COG2130	NADP-dependent
LH22_RS12600	COG1187	pseudouridine synthase activity
LH22_RS12620	COG1175	transmembrane transport
LH22_RS12625	COG1653	transport
LH22_RS12630	COG3842	ATPase activity
LH22_RS12640	COG2084	Dehydrogenase
LH22_RS12645	COG1082	Xylose isomerase domain protein TIM barrel
LH22_RS12650	COG0149	triose-phosphate isomerase activity
LH22_RS12655	COG2376	Dihydroxyacetone kinase
LH22_RS12665	COG0698	ribose 5-phosphate isomerase
LH22_RS12670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH22_RS12675	COG0095	Lipoate-protein ligase
LH22_RS12685	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH22_RS12695	COG1309	transcriptional regulator
LH22_RS12710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH22_RS12730	COG1280	lysine exporter protein (LysE YggA)
LH22_RS12740	COG0753	catalase activity
LH22_RS12750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH22_RS12755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS12765	COG2271	Major facilitator Superfamily
LH22_RS12785	COG0583	DNA-binding transcription factor activity
LH22_RS12800	COG2271	Major facilitator Superfamily
LH22_RS12810	COG0246	Mannitol dehydrogenase
LH22_RS12820	COG2186	Transcriptional regulator
LH22_RS12825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH22_RS12845	COG4948	Mandelate Racemase Muconate Lactonizing
LH22_RS12850	COG0747	negative chemotaxis
LH22_RS12855	COG0601	transmembrane transport
LH22_RS12860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH22_RS12865	COG0444	Belongs to the ABC transporter superfamily
LH22_RS12870	COG4608	Belongs to the ABC transporter superfamily
LH22_RS12885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH22_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS12945	COG0205	6-phosphofructokinase activity
LH22_RS12950	COG0277	FAD linked oxidase domain protein
LH22_RS12990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH22_RS12995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH22_RS13005	COG2084	Dehydrogenase
LH22_RS13010	COG1309	transcriptional regulator
LH22_RS13020	COG4772	TonB-dependent receptor
LH22_RS13025	COG1335	isochorismatase
LH22_RS13035	COG1396	sequence-specific DNA binding
LH22_RS13040	COG3135	benzoate transporter
LH22_RS13065	COG4290	ribonuclease
LH22_RS13075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH22_RS13100	COG0114	fumarate hydratase activity
LH22_RS13105	COG1482	cell wall glycoprotein biosynthetic process
LH22_RS13110	COG5339	Protein conserved in bacteria
LH22_RS13115	COG1609	Transcriptional regulator
LH22_RS13120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS13120	COG1263	PTS System
LH22_RS13125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LH22_RS13130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH22_RS13135	COG0673	inositol 2-dehydrogenase activity
LH22_RS13145	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS13155	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS13160	COG1069	ribulokinase activity
LH22_RS13165	COG2160	L-arabinose isomerase activity
LH22_RS13170	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS13175	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS13180	COG1129	ABC transporter
LH22_RS13185	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS13200	COG4657	Part of a membrane complex involved in electron transport
LH22_RS13205	COG2878	Part of a membrane complex involved in electron transport
LH22_RS13210	COG4656	Part of a membrane complex involved in electron transport
LH22_RS13215	COG4658	electron transport chain
LH22_RS13220	COG4659	FMN binding
LH22_RS13225	COG4660	Part of a membrane complex involved in electron transport
LH22_RS13230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH22_RS13240	COG4682	membrane
LH22_RS13280	COG0504	CTP synthase activity
LH22_RS13290	COG0583	DNA-binding transcription factor activity
LH22_RS13295	COG0625	glutathione transferase activity
LH22_RS13300	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LH22_RS13315	COG3895	Periplasmic Protein
LH22_RS13330	COG1846	Transcriptional regulator
LH22_RS13340	COG1566	PFAM secretion protein HlyD family protein
LH22_RS13345	COG1289	transmembrane transporter activity
LH22_RS13355	COG2032	superoxide dismutase activity
LH22_RS13360	COG4989	oxidoreductase activity
LH22_RS13365	COG2194	sulfuric ester hydrolase activity
LH22_RS13370	COG1309	transcriptional regulator
LH22_RS13375	COG1902	pentaerythritol trinitrate reductase activity
LH22_RS13380	COG0346	lactoylglutathione lyase activity
LH22_RS13385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH22_RS13390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH22_RS13395	COG0791	NLP P60 protein
LH22_RS13400	COG1609	Transcriptional regulator
LH22_RS13405	COG0583	DNA-binding transcription factor activity
LH22_RS13410	COG2814	Major facilitator Superfamily
LH22_RS13415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH22_RS13420	COG0307	riboflavin synthase, alpha
LH22_RS13455	COG1388	LysM domain
LH22_RS13455	COG1376	ErfK ybiS ycfS ynhG family protein
LH22_RS13460	COG2166	iron-sulfur cluster assembly
LH22_RS13470	COG0719	Fe-S assembly protein
LH22_RS13475	COG0396	ATPase activity
LH22_RS13480	COG0719	Fe-S assembly protein
LH22_RS13485	COG0316	Belongs to the HesB IscA family
LH22_RS13495	COG0277	FAD linked oxidase domain protein
LH22_RS13495	COG0247	lactate metabolic process
LH22_RS13500	COG0628	permease
LH22_RS13505	COG0574	Belongs to the PEP-utilizing enzyme family
LH22_RS13505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH22_RS13510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH22_RS13515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH22_RS13520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH22_RS13530	COG0791	NLP P60 protein
LH22_RS13540	COG0386	Belongs to the glutathione peroxidase family
LH22_RS13545	COG4139	cobalamin transport
LH22_RS13555	COG0776	regulation of translation
LH22_RS13560	COG0072	phenylalanine-tRNA ligase activity
LH22_RS13560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH22_RS13575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH22_RS13585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH22_RS13590	COG3137	Salt-induced outer membrane protein
LH22_RS13600	COG3001	Fructosamine kinase
LH22_RS13610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH22_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS13625	COG1988	membrane-bound metal-dependent
LH22_RS13630	COG1823	symporter activity
LH22_RS13640	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS13645	COG2814	Major facilitator Superfamily
LH22_RS13650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LH22_RS13655	COG0322	excinuclease ABC activity
LH22_RS13660	COG3678	ATP-independent chaperone mediated protein folding
LH22_RS13665	COG2988	succinylglutamate desuccinylase activity
LH22_RS13670	COG3724	N-succinylarginine dihydrolase activity
LH22_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
LH22_RS13705	COG4932	domain protein
LH22_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS13715	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS13720	COG1129	ABC transporter
LH22_RS13730	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS13735	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS13740	COG1349	DNA-binding transcription factor activity
LH22_RS13750	COG0745	RESPONSE REGULATOR receiver
LH22_RS13760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH22_RS13765	COG0840	transmembrane signaling receptor activity
LH22_RS13770	COG0840	transmembrane signaling receptor activity
LH22_RS13780	COG0835	chemotaxis
LH22_RS13850	COG4650	regulator
LH22_RS13855	COG3541	Predicted nucleotidyltransferase
LH22_RS13875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH22_RS13960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH22_RS13970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH22_RS13975	COG3290	protein histidine kinase activity
LH22_RS13980	COG4565	transcriptional regulatory protein
LH22_RS14000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LH22_RS14000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LH22_RS14015	COG0519	Catalyzes the synthesis of GMP from XMP
LH22_RS14015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH22_RS14020	COG0697	spore germination
LH22_RS14025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH22_RS14030	COG3381	protein complex oligomerization
LH22_RS14035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LH22_RS14050	COG4774	siderophore transport
LH22_RS14055	COG2261	transglycosylase associated protein
LH22_RS14060	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LH22_RS14065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH22_RS14070	COG3958	Transketolase
LH22_RS14075	COG3959	Transketolase, thiamine diphosphate binding domain
LH22_RS14080	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS14085	COG1129	ABC transporter
LH22_RS14095	COG1879	ABC-type sugar transport system periplasmic component
LH22_RS14100	COG2390	Transcriptional regulator
LH22_RS14110	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH22_RS14120	COG0454	-acetyltransferase
LH22_RS14170	COG0668	transmembrane transport
LH22_RS14175	COG0538	isocitrate dehydrogenase activity
LH22_RS14180	COG1187	pseudouridine synthase activity
LH22_RS14195	COG2915	High frequency lysogenization protein hflD homolog
LH22_RS14200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH22_RS14205	COG0745	RESPONSE REGULATOR receiver
LH22_RS14210	COG2205	protein histidine kinase activity
LH22_RS14215	COG2850	peptidyl-arginine hydroxylation
LH22_RS14225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH22_RS14230	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH22_RS14240	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH22_RS14250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH22_RS14255	COG3134	Outer membrane lipoprotein
LH22_RS14260	COG1252	NADH dehydrogenase
LH22_RS14275	COG0510	thiamine kinase activity
LH22_RS14280	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LH22_RS14285	COG5633	Lipoprotein
LH22_RS14290	COG0537	adenosine 5'-monophosphoramidase activity
LH22_RS14300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LH22_RS14310	COG0084	hydrolase, TatD family'
LH22_RS14315	COG0470	DNA polymerase III
LH22_RS14325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH22_RS14330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH22_RS14335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH22_RS14340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH22_RS14355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH22_RS14360	COG0416	fatty acid biosynthetic process
LH22_RS14365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH22_RS14370	COG1399	metal-binding, possibly nucleic acid-binding protein
LH22_RS14385	COG1530	ribonuclease E activity
LH22_RS14385	COG1530	ribonuclease E activity
LH22_RS14390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH22_RS14400	COG3951	Flagellar rod assembly protein muramidase FlgJ
LH22_RS14400	COG1705	Flagellar rod assembly protein muramidase FlgJ
LH22_RS14425	COG1749	Flagellar hook protein flgE
LH22_RS14430	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LH22_RS14435	COG1558	bacterial-type flagellum-dependent cell motility
LH22_RS14440	COG1815	bacterial-type flagellum-dependent cell motility
LH22_RS14445	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LH22_RS14460	COG0728	peptidoglycan biosynthetic process
LH22_RS14465	COG0673	inositol 2-dehydrogenase activity
LH22_RS14475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH22_RS14485	COG2999	glutathione oxidoreductase activity
LH22_RS14495	COG0418	dihydroorotase activity
LH22_RS14520	COG3038	cytochrome b561
LH22_RS14530	COG1054	Belongs to the UPF0176 family
LH22_RS14535	COG1560	Kdo2-lipid A biosynthetic process
LH22_RS14550	COG5645	(Lipo)protein
LH22_RS14555	COG2943	transferase activity, transferring hexosyl groups
LH22_RS14570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH22_RS14590	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS14630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH22_RS14645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH22_RS14650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH22_RS14695	COG0659	secondary active sulfate transmembrane transporter activity
LH22_RS14730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH22_RS14735	COG0322	excinuclease ABC activity
LH22_RS14740	COG2197	response regulator
LH22_RS14755	COG2197	response regulator
LH22_RS14770	COG1113	amino acid transport
LH22_RS14780	COG1309	transcriptional regulator
LH22_RS14800	COG2267	carboxylic ester hydrolase activity
LH22_RS14805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH22_RS14810	COG2233	PERMEase
LH22_RS14835	COG1012	belongs to the aldehyde dehydrogenase family
LH22_RS14855	COG0670	Belongs to the BI1 family
LH22_RS14870	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH22_RS14880	COG1832	CoA-binding protein
LH22_RS14895	COG0210	DNA helicase
LH22_RS14900	COG3304	Inner membrane component domain
LH22_RS14905	COG1289	transmembrane transporter activity
LH22_RS14910	COG3070	regulator of competence-specific genes
LH22_RS14920	COG2885	chlorophyll binding
LH22_RS14920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH22_RS14925	COG3120	sequence-specific DNA binding
LH22_RS14930	COG1067	ATP-dependent peptidase activity
LH22_RS14935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH22_RS14940	COG3009	Protein conserved in bacteria
LH22_RS14945	COG3008	intermembrane lipid transfer
LH22_RS14945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH22_RS14950	COG2995	paraquat-inducible protein a
LH22_RS14955	COG0488	(ABC) transporter
LH22_RS14960	COG0116	Belongs to the methyltransferase superfamily
LH22_RS14960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH22_RS14965	COG3217	Mosc domain protein beta barrel domain protein
LH22_RS14965	COG0633	Ferredoxin
LH22_RS14975	COG0167	dihydroorotate dehydrogenase activity
LH22_RS14980	COG1216	Glycosyl transferase, family 2
LH22_RS14990	COG1216	Glycosyl transferase, family 2
LH22_RS14995	COG0431	NADPH-dependent FMN reductase
LH22_RS15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH22_RS15005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS15010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH22_RS15020	COG0308	aminopeptidase N
LH22_RS15025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH22_RS15030	COG0017	Asparaginyl-tRNA synthetase
LH22_RS15040	COG1448	Aminotransferase
LH22_RS15045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH22_RS15050	COG3108	Peptidase M15
LH22_RS15055	COG2989	Protein conserved in bacteria
LH22_RS15065	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LH22_RS15070	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LH22_RS15075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH22_RS15080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LH22_RS15085	COG3173	Aminoglycoside phosphotransferase
LH22_RS15095	COG2835	tetraacyldisaccharide 4'-kinase activity
LH22_RS15100	COG3214	Protein conserved in bacteria
LH22_RS15115	COG2333	competence protein COMEC
LH22_RS15115	COG0658	competence protein
LH22_RS15120	COG0776	regulation of translation
LH22_RS15125	COG0539	negative regulation of cytoplasmic translation
LH22_RS15140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH22_RS15145	COG1944	ATP diphosphatase activity
LH22_RS15150	COG2116	formate transmembrane transporter activity
LH22_RS15155	COG1882	Formate acetyltransferase
LH22_RS15160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LH22_RS15165	COG0477	Major facilitator Superfamily
LH22_RS15170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH22_RS15175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH22_RS15185	COG1674	ftsk spoiiie
LH22_RS15185	COG3107	peptidoglycan biosynthetic process
LH22_RS15195	COG0492	ferredoxin-NADP+ reductase activity
LH22_RS15200	COG4988	ABC transporter
LH22_RS15205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH22_RS15210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LH22_RS15215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH22_RS15220	COG0542	response to heat
LH22_RS15225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LH22_RS15230	COG1278	Cold shock
LH22_RS15235	COG3593	DNA synthesis involved in DNA repair
LH22_RS15240	COG2431	L-lysine efflux transmembrane transporter activity
LH22_RS15245	COG0028	Belongs to the TPP enzyme family
LH22_RS15250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LH22_RS15255	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH22_RS15260	COG0393	Putative heavy-metal-binding
LH22_RS15275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS15280	COG4215	(ABC) transporter
LH22_RS15285	COG4160	amino acid transport
LH22_RS15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS15295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH22_RS15305	COG1177	transmembrane transport
LH22_RS15310	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH22_RS15315	COG3842	ATPase activity
LH22_RS15320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LH22_RS15330	COG0189	ligase activity
LH22_RS15335	COG0778	Nitroreductase
LH22_RS15345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH22_RS15365	COG0671	phosphoesterase, PA-phosphatase related
LH22_RS15370	COG1686	Belongs to the peptidase S11 family
LH22_RS15380	COG2133	pyrroloquinoline quinone binding
LH22_RS15395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH22_RS15425	COG4172	Belongs to the ABC transporter superfamily
LH22_RS15435	COG0303	'Molybdopterin
LH22_RS15440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH22_RS15445	COG0488	(ABC) transporter
LH22_RS15450	COG2916	Histone family protein nucleoid-structuring protein H-NS
LH22_RS15455	COG2814	Major facilitator Superfamily
LH22_RS15465	COG2814	Major facilitator Superfamily
LH22_RS15470	COG1566	PFAM secretion protein HlyD family protein
LH22_RS15475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LH22_RS15480	COG1321	iron dependent repressor
LH22_RS15505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH22_RS15510	COG5006	permease, DMT superfamily
LH22_RS15515	COG0783	Belongs to the Dps family
LH22_RS15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS15525	COG0765	amino acid transport
LH22_RS15530	COG1126	abc transporter atp-binding protein
LH22_RS15535	COG0668	transmembrane transport
LH22_RS15540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LH22_RS15545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH22_RS15550	COG2986	histidine ammonia-lyase
LH22_RS15580	COG1228	amidohydrolase
LH22_RS15585	COG0402	S-adenosylhomocysteine deaminase activity
LH22_RS15600	COG2986	histidine ammonia-lyase
LH22_RS15605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH22_RS15610	COG1473	amidohydrolase
LH22_RS15615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH22_RS15635	COG0371	Dehydrogenase
LH22_RS15655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS15665	COG0765	amino acid transport
LH22_RS15670	COG0165	Argininosuccinate lyase
LH22_RS15690	COG0789	Transcriptional regulator
LH22_RS15695	COG1174	glycine betaine transport
LH22_RS15700	COG1125	glycine betaine transport
LH22_RS15705	COG1174	glycine betaine transport
LH22_RS15710	COG1732	Glycine betaine
LH22_RS15715	COG0477	Major facilitator Superfamily
LH22_RS15720	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LH22_RS15735	COG0673	inositol 2-dehydrogenase activity
LH22_RS15740	COG1609	Transcriptional regulator
LH22_RS15765	COG1472	Belongs to the glycosyl hydrolase 3 family
LH22_RS15770	COG0277	FAD linked oxidase domain protein
LH22_RS15775	COG3264	Mechanosensitive ion channel
LH22_RS15775	COG1511	domain protein
LH22_RS15780	COG1686	Belongs to the peptidase S11 family
LH22_RS15790	COG0586	Pfam SNARE associated Golgi protein
LH22_RS15800	COG3387	PFAM Glycoside hydrolase 15-related
LH22_RS15805	COG1376	ErfK ybiS ycfS ynhG family protein
LH22_RS15815	COG0306	phosphate transporter
LH22_RS15825	COG0477	Major facilitator Superfamily
LH22_RS15835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH22_RS15840	COG0513	Belongs to the DEAD box helicase family
LH22_RS15850	COG3568	Endonuclease Exonuclease Phosphatase
LH22_RS15855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH22_RS15860	COG0392	lysyltransferase activity
LH22_RS15865	COG0670	Belongs to the BI1 family
LH22_RS15875	COG0314	molybdopterin synthase activity
LH22_RS15880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LH22_RS15885	COG0315	cyclic pyranopterin monophosphate synthase activity
LH22_RS15890	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH22_RS15905	COG0556	nucleotide-excision repair
LH22_RS15920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH22_RS15925	COG2226	methyltransferase
LH22_RS15945	COG1881	PFAM PEBP family protein
LH22_RS15950	COG2706	6-phosphogluconolactonase activity
LH22_RS15955	COG0561	phosphatase activity
LH22_RS15965	COG4149	molybdate abc transporter
LH22_RS15970	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH22_RS15980	COG2005	Transcriptional regulator
LH22_RS15980	COG3585	molybdate ion transport
LH22_RS15985	COG1119	ATPase activity
LH22_RS15990	COG1085	galactose-1-phosphate uridylyltransferase
LH22_RS16000	COG2017	converts alpha-aldose to the beta-anomer
LH22_RS16005	COG0588	phosphoglycerate mutase activity
LH22_RS16010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH22_RS16020	COG2197	response regulator
LH22_RS16025	COG2205	protein histidine kinase activity
LH22_RS16025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH22_RS16030	COG1230	cation diffusion facilitator family transporter
LH22_RS16040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH22_RS16075	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LH22_RS16080	COG2885	chlorophyll binding
LH22_RS16090	COG3064	Membrane
LH22_RS16095	COG0848	biopolymer transport protein
LH22_RS16100	COG0811	peptide transport
LH22_RS16105	COG0824	Thioesterase
LH22_RS16110	COG3790	cyd operon protein YbgE
LH22_RS16115	COG1294	oxidase, subunit
LH22_RS16120	COG1271	oxidase subunit
LH22_RS16125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH22_RS16130	COG0045	succinate-CoA ligase (ADP-forming) activity
LH22_RS16135	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH22_RS16140	COG0567	Dehydrogenase, E1 component
LH22_RS16145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH22_RS16155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LH22_RS16165	COG0372	Belongs to the citrate synthase family
LH22_RS16175	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LH22_RS16195	COG1984	allophanate hydrolase subunit 2
LH22_RS16200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH22_RS16210	COG0415	Belongs to the DNA photolyase family
LH22_RS16215	COG3272	Protein of unknown function (DUF1722)
LH22_RS16225	COG0745	RESPONSE REGULATOR receiver
LH22_RS16230	COG0033	Phosphoglucomutase
LH22_RS16235	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LH22_RS16240	COG0596	Alpha beta hydrolase
LH22_RS16255	COG0735	belongs to the Fur family
LH22_RS16265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH22_RS16270	COG2190	(PTS) system
LH22_RS16270	COG1263	PTS System
LH22_RS16270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH22_RS16275	COG0363	glucosamine-6-phosphate deaminase activity
LH22_RS16280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LH22_RS16285	COG1846	Transcriptional regulator
LH22_RS16285	COG1940	carbohydrate kinase activity
LH22_RS16290	COG0647	UMP catabolic process
LH22_RS16295	COG0367	asparagine synthase
LH22_RS16340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH22_RS16345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH22_RS16350	COG1702	phosphate starvation-inducible protein PhoH
LH22_RS16355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH22_RS16365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH22_RS16375	COG0765	amino acid transport
LH22_RS16380	COG0765	amino acid transport
LH22_RS16385	COG1126	abc transporter atp-binding protein
LH22_RS16390	COG2888	peptidyl-tyrosine sulfation
LH22_RS16395	COG0495	leucyl-tRNA aminoacylation
LH22_RS16400	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LH22_RS16405	COG1466	dna polymerase III delta subunit
LH22_RS16415	COG0799	negative regulation of ribosome biogenesis
LH22_RS16420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH22_RS16425	COG0768	penicillin binding
LH22_RS16430	COG0772	Belongs to the SEDS family
LH22_RS16435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LH22_RS16440	COG1686	Belongs to the peptidase S11 family
LH22_RS16445	COG2921	Belongs to the UPF0250 family
LH22_RS16450	COG0321	lipoyl(octanoyl) transferase activity
LH22_RS16455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH22_RS16460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH22_RS16480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH22_RS16515	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH22_RS16520	COG2610	gluconate transmembrane transporter activity
LH22_RS16525	COG1454	alcohol dehydrogenase
LH22_RS16530	COG0561	phosphatase activity
LH22_RS16540	COG3813	Protein conserved in bacteria
LH22_RS16545	COG0628	permease
LH22_RS16550	COG0628	permease
LH22_RS16555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH22_RS16605	COG2003	Belongs to the UPF0758 family
LH22_RS16675	COG3772	lysozyme
LH22_RS16710	COG0582	viral genome integration into host DNA
LH22_RS16725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH22_RS16730	COG2501	S4 domain
LH22_RS16735	COG0215	cysteine-tRNA ligase activity
LH22_RS16740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH22_RS16750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH22_RS16755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH22_RS16760	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LH22_RS16765	COG4181	ATPase activity
LH22_RS16770	COG2755	lipolytic protein G-D-S-L family
LH22_RS16775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH22_RS16780	COG0300	oxidoreductase activity
LH22_RS16785	COG3118	belongs to the thioredoxin family
LH22_RS16790	COG0330	HflC and HflK could
LH22_RS16795	COG1585	Membrane protein implicated in regulation of membrane protease activity
LH22_RS16805	COG2217	Heavy metal translocating P-type atpase
LH22_RS16810	COG3735	TraB family
LH22_RS16815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH22_RS16830	COG0737	Belongs to the 5'-nucleotidase family
LH22_RS16835	COG2223	nitrite transmembrane transporter activity
LH22_RS16840	COG4651	solute:proton antiporter activity
LH22_RS16840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH22_RS16845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH22_RS16850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH22_RS16855	COG0563	adenylate kinase activity
LH22_RS16870	COG0326	Molecular chaperone. Has ATPase activity
LH22_RS16875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH22_RS16880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH22_RS16885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LH22_RS16890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH22_RS16895	COG2832	Protein of unknown function (DUF454)
LH22_RS16900	COG3923	Primosomal replication protein n
LH22_RS16905	COG2261	transglycosylase associated protein
LH22_RS16910	COG1309	transcriptional regulator
LH22_RS16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH22_RS16920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH22_RS16925	COG0254	rRNA binding
LH22_RS16930	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH22_RS16935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH22_RS16940	COG1121	(ABC) transporter
LH22_RS16965	COG3695	enzyme binding
LH22_RS16970	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LH22_RS16975	COG1946	Acyl-CoA thioesterase
LH22_RS16980	COG0004	ammonium transporteR
LH22_RS16985	COG0347	Belongs to the P(II) protein family
LH22_RS16990	COG1132	(ABC) transporter
LH22_RS16995	COG1132	(ABC) transporter
LH22_RS17000	COG1522	sequence-specific DNA binding
LH22_RS17015	COG4533	DNA binding
LH22_RS17025	COG0824	Thioesterase
LH22_RS17030	COG1555	photosystem II stabilization
LH22_RS17035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH22_RS17040	COG0776	regulation of translation
LH22_RS17065	COG0271	Belongs to the BolA IbaG family
LH22_RS17070	COG3056	Lipoprotein
LH22_RS17075	COG2223	nitrite transmembrane transporter activity
LH22_RS17080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH22_RS17085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH22_RS17090	COG1845	cytochrome c oxidase, subunit III
LH22_RS17095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH22_RS17100	COG0109	protoheme IX farnesyltransferase activity
LH22_RS17105	COG2814	Major facilitator Superfamily
LH22_RS17125	COG1666	GTP binding
LH22_RS17130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH22_RS17140	COG0301	tRNA thio-modification
LH22_RS17140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH22_RS17150	COG0142	geranyltranstransferase activity
LH22_RS17155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH22_RS17160	COG0667	Aldo Keto reductase
LH22_RS17165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LH22_RS17170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LH22_RS17175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH22_RS17180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH22_RS17185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH22_RS17185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH22_RS17195	COG1652	LysM domain
LH22_RS17200	COG4238	major outer membrane lipoprotein
LH22_RS17205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH22_RS17210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH22_RS17215	COG1862	Preprotein translocase
LH22_RS17220	COG0343	queuine tRNA-ribosyltransferase activity
LH22_RS17225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH22_RS17250	COG1114	Component of the transport system for branched-chain amino acids
LH22_RS17255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH22_RS17265	COG5002	protein histidine kinase activity
LH22_RS17270	COG0745	RESPONSE REGULATOR receiver
LH22_RS17275	COG0420	3'-5' exonuclease activity
LH22_RS17280	COG0419	ATPase involved in DNA repair
LH22_RS17305	COG1940	carbohydrate kinase activity
LH22_RS17310	COG2974	May be involved in recombination
LH22_RS17315	COG3123	guanosine phosphorylase activity
LH22_RS17320	COG4126	flavin adenine dinucleotide binding
LH22_RS17345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH22_RS17350	COG3416	Protein conserved in bacteria
LH22_RS17355	COG1671	Belongs to the UPF0178 family
LH22_RS17360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LH22_RS17375	COG0363	glucosamine-6-phosphate deaminase activity
LH22_RS17380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH22_RS17395	COG3250	beta-galactosidase activity
LH22_RS17400	COG2814	Major facilitator Superfamily
LH22_RS17420	COG5001	Diguanylate cyclase
LH22_RS17440	COG1764	response to oxidative stress
LH22_RS17445	COG1304	FMN binding
LH22_RS17450	COG2186	Transcriptional regulator
LH22_RS17460	COG2807	transmembrane transport
LH22_RS17465	COG0583	DNA-binding transcription factor activity
LH22_RS17470	COG0402	S-adenosylhomocysteine deaminase activity
LH22_RS17480	COG0513	Belongs to the DEAD box helicase family
LH22_RS17485	COG0784	Response regulator, receiver
LH22_RS17485	COG0835	chemotaxis
LH22_RS17490	COG0840	transmembrane signaling receptor activity
LH22_RS17495	COG0814	amino acid
LH22_RS17500	COG1442	glycosyl transferase family 8
LH22_RS17500	COG1216	Glycosyl transferase, family 2
LH22_RS17535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH22_RS17540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LH22_RS17545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH22_RS17555	COG1073	alpha beta
LH22_RS17560	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LH22_RS17565	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH22_RS17570	COG1129	ABC transporter
LH22_RS17575	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH22_RS17590	COG3034	peptidoglycan biosynthetic process
LH22_RS17595	COG0121	glutamine amidotransferase
LH22_RS17600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH22_RS17605	COG1960	acyl-CoA dehydrogenase activity
LH22_RS17610	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LH22_RS17630	COG0235	Class ii aldolase
LH22_RS17635	COG0436	Aminotransferase
LH22_RS17640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH22_RS17645	COG4680	protein conserved in bacteria
LH22_RS17650	COG5499	transcription regulator containing HTH domain
LH22_RS17655	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LH22_RS17660	COG2351	hydroxyisourate hydrolase activity
LH22_RS17675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH22_RS17685	COG0765	amino acid transport
LH22_RS17740	COG1953	Uracil, thiamine, allantoin
LH22_RS17755	COG0328	RNA-DNA hybrid ribonuclease activity
LH22_RS17760	COG2226	methyltransferase
LH22_RS17765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH22_RS17770	COG1388	LysM domain
LH22_RS17770	COG0741	lytic transglycosylase activity
LH22_RS17775	COG3021	interspecies interaction between organisms
LH22_RS17780	COG2814	Major facilitator Superfamily
LH22_RS17785	COG0583	DNA-binding transcription factor activity
LH22_RS17820	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH22_RS17830	COG2011	ABC-type metal ion transport system permease component
LH22_RS17845	COG1720	tRNA m6t6A37 methyltransferase activity
LH22_RS17855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH22_RS17860	COG4568	rho-dependent transcription termination
LH22_RS17870	COG0037	tRNA processing
LH22_RS17875	COG0346	lactoylglutathione lyase activity
LH22_RS17880	COG1982	Orn Lys Arg decarboxylase major
LH22_RS17885	COG0825	malonyl-CoA metabolic process
LH22_RS17895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH22_RS17900	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH22_RS17910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH22_RS17925	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH22_RS17935	COG0575	Belongs to the CDS family
LH22_RS17940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH22_RS17945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH22_RS17950	COG0233	cytoplasmic translational termination
LH22_RS17955	COG0528	UMP kinase activity
LH22_RS17960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH22_RS17975	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH22_RS17990	COG2186	Transcriptional regulator
LH22_RS18000	COG3835	regulator
LH22_RS18005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH22_RS18010	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH22_RS18015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH22_RS18030	COG0316	Belongs to the HesB IscA family
LH22_RS18035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH22_RS18040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH22_RS18045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH22_RS18050	COG1120	ATPase activity
LH22_RS18055	COG4774	siderophore transport
LH22_RS18060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH22_RS18065	COG1643	Atp-dependent helicase
LH22_RS18070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LH22_RS18075	COG1489	DNA binding
LH22_RS18090	COG0617	tRNA 3'-terminal CCA addition
LH22_RS18095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH22_RS18105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH22_RS18110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH22_RS18115	COG0842	Transport permease protein
LH22_RS18120	COG1131	(ABC) transporter
LH22_RS18130	COG0626	cystathionine gamma-synthase activity
LH22_RS18135	COG2132	Multicopper oxidase
LH22_RS18145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH22_RS18155	COG1349	DNA-binding transcription factor activity
LH22_RS18160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH22_RS18165	COG3395	kinase activity
LH22_RS18175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH22_RS18180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH22_RS18185	COG2271	Major facilitator Superfamily
LH22_RS18190	COG2271	Major facilitator Superfamily
LH22_RS18205	COG1049	propionate catabolic process, 2-methylcitrate cycle
LH22_RS18210	COG0667	Aldo Keto reductase
LH22_RS18215	COG0583	DNA-binding transcription factor activity
LH22_RS18220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH22_RS18225	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH22_RS18230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH22_RS18245	COG2211	Major facilitator Superfamily
LH22_RS18250	COG3940	Belongs to the glycosyl hydrolase 43 family
LH22_RS18255	COG3725	Membrane protein required for beta-lactamase induction
LH22_RS18260	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH22_RS18265	COG0157	Belongs to the NadC ModD family
LH22_RS18275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LH22_RS18280	COG1459	type II secretion system
LH22_RS18285	COG0516	GMP reductase activity
LH22_RS18290	COG0237	dephospho-CoA kinase activity
LH22_RS18300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LH22_RS18305	COG0494	nUDIX hydrolase
LH22_RS18320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH22_RS18325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH22_RS18330	COG0849	cell division
LH22_RS18340	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH22_RS18345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH22_RS18355	COG0772	Belongs to the SEDS family
LH22_RS18370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH22_RS18375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH22_RS18380	COG0768	penicillin binding
LH22_RS18395	COG2001	Belongs to the MraZ family
LH22_RS18410	COG0028	Belongs to the TPP enzyme family
LH22_RS18415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH22_RS18420	COG0473	3-isopropylmalate dehydrogenase activity
LH22_RS18425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH22_RS18430	COG0066	3-isopropylmalate dehydratase activity
LH22_RS18450	COG4143	(ABC) transporter
LH22_RS18455	COG1178	ABC-type Fe3 transport system permease component
LH22_RS18460	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LH22_RS18465	COG0586	Pfam SNARE associated Golgi protein
LH22_RS18470	COG0417	DNA replication proofreading
LH22_RS18475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH22_RS18480	COG0564	pseudouridine synthase activity
LH22_RS18485	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LH22_RS18495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH22_RS18500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH22_RS18505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH22_RS18510	COG2967	ApaG domain
LH22_RS18515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH22_RS18520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LH22_RS18535	COG0505	Belongs to the CarA family
LH22_RS18540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH22_RS18545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH22_RS18550	COG1047	Peptidyl-prolyl cis-trans
LH22_RS18555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH22_RS18560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH22_RS18565	COG0196	riboflavin kinase activity
LH22_RS18570	COG0268	Binds directly to 16S ribosomal RNA
LH22_RS18585	COG0443	Heat shock 70 kDa protein
LH22_RS18595	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH22_RS18600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH22_RS18605	COG3022	response to hydroperoxide
LH22_RS18610	COG3385	transposase activity
LH22_RS18625	COG0460	homoserine dehydrogenase
LH22_RS18625	COG0527	aspartate kinase activity
LH22_RS18630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LH22_RS18635	COG0745	RESPONSE REGULATOR receiver
LH22_RS18640	COG3045	CreA protein
LH22_RS18645	COG2207	Transcriptional regulator
LH22_RS18645	COG3708	Transcriptional regulator
LH22_RS18650	COG0406	alpha-ribazole phosphatase activity
LH22_RS18655	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LH22_RS18665	COG0741	lytic transglycosylase activity
LH22_RS18675	COG0439	Biotin carboxylase
LH22_RS18680	COG1802	Transcriptional regulator
LH22_RS18700	COG1129	ABC transporter
LH22_RS18705	COG0410	ABC transporter
LH22_RS18715	COG0738	Major facilitator superfamily
LH22_RS18725	COG1349	DNA-binding transcription factor activity
LH22_RS18730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH22_RS18735	COG0488	(ABC) transporter
LH22_RS18745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LH22_RS18750	COG0560	Phosphoserine phosphatase
LH22_RS18755	COG3726	membrane protein affecting hemolysin expression
LH22_RS18760	COG3550	peptidyl-serine autophosphorylation
LH22_RS18765	COG1011	Hydrolase
LH22_RS18770	COG0456	acetyltransferase
LH22_RS18775	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LH22_RS18780	COG2813	Specifically methylates the guanine in position
LH22_RS18805	COG3706	GGDEF domain
LH22_RS18810	COG4114	ferric iron reductase
LH22_RS18815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH22_RS18820	COG2814	Major facilitator Superfamily
LH22_RS18830	COG1609	Transcriptional regulator
LH22_RS18835	COG0477	Major facilitator Superfamily
LH22_RS18860	COG1942	4-Oxalocrotonate Tautomerase
LH22_RS18890	COG1464	Belongs to the NlpA lipoprotein family
LH22_RS18900	COG3012	SEC-C Motif Domain Protein
LH22_RS18900	COG3318	Belongs to the UPF0149 family
LH22_RS18915	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH22_RS18970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH22_RS18975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH22_RS19010	COG0433	COG0433 Predicted ATPase
LH22_RS19015	COG2733	membrane
LH22_RS19020	COG0795	lipopolysaccharide-transporting ATPase activity
LH22_RS19025	COG0795	lipopolysaccharide-transporting ATPase activity
LH22_RS19030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH22_RS19035	COG2927	DNA polymerase III (CHI subunit)
LH22_RS19055	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LH22_RS19060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH22_RS19070	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LH22_RS19080	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LH22_RS19095	COG0701	Predicted permease
LH22_RS19100	COG3787	Belongs to the UPF0306 family
LH22_RS19110	COG3153	acetyltransferase
LH22_RS19115	COG3154	lipid carrier protein
LH22_RS19120	COG0826	peptidase U32
LH22_RS19125	COG0826	peptidase U32
LH22_RS19130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH22_RS19135	COG2207	Transcriptional regulator
LH22_RS19140	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS19145	COG0513	Belongs to the DEAD box helicase family
LH22_RS19160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH22_RS19165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH22_RS19170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH22_RS19180	COG0195	Participates in both transcription termination and antitermination
LH22_RS19185	COG0779	Required for maturation of 30S ribosomal subunits
LH22_RS19200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH22_RS19205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH22_RS19210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH22_RS19220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH22_RS19225	COG1534	Rna-binding protein
LH22_RS19235	COG2027	D-alanyl-D-alanine carboxypeptidase
LH22_RS19240	COG0745	RESPONSE REGULATOR receiver
LH22_RS19245	COG0642	Histidine kinase
LH22_RS19250	COG4771	TonB-dependent receptor
LH22_RS19255	COG2382	esterase
LH22_RS19260	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LH22_RS19260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH22_RS19265	COG1120	ATPase activity
LH22_RS19270	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH22_RS19275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH22_RS19285	COG4592	Periplasmic binding protein
LH22_RS19290	COG1169	isochorismate synthase
LH22_RS19295	COG1021	2,3-dihydroxybenzoate-AMP ligase
LH22_RS19300	COG3433	isochorismatase activity
LH22_RS19300	COG1535	isochorismatase
LH22_RS19305	COG1028	Short-chain dehydrogenase reductase Sdr
LH22_RS19315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH22_RS19320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LH22_RS19325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH22_RS19330	COG0142	geranyltranstransferase activity
LH22_RS19335	COG3423	Transcriptional regulator
LH22_RS19345	COG5007	Belongs to the BolA IbaG family
LH22_RS19350	COG3113	response to antibiotic
LH22_RS19355	COG2854	intermembrane phospholipid transfer
LH22_RS19360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH22_RS19365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH22_RS19370	COG1127	ABC transporter
LH22_RS19375	COG0530	calcium, potassium:sodium antiporter activity
LH22_RS19380	COG0517	IMP dehydrogenase activity
LH22_RS19380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LH22_RS19385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LH22_RS19390	COG3117	lipopolysaccharide transmembrane transporter activity
LH22_RS19395	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LH22_RS19400	COG1137	ATPase activity
LH22_RS19405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH22_RS19410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH22_RS19425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH22_RS19435	COG2198	Histidine kinase
LH22_RS19435	COG0784	Response regulator, receiver
LH22_RS19435	COG5002	protein histidine kinase activity
LH22_RS19440	COG0070	glutamate synthase
LH22_RS19440	COG0069	glutamate synthase activity
LH22_RS19440	COG0067	glutamate synthase
LH22_RS19445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LH22_RS19450	COG2969	positive regulation of protein catabolic process
LH22_RS19455	COG0625	glutathione transferase activity
LH22_RS19460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH22_RS19465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH22_RS19470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH22_RS19475	COG3105	Protein conserved in bacteria
LH22_RS19480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH22_RS19485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH22_RS19490	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LH22_RS19495	COG5510	response to toxic substance
LH22_RS19505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH22_RS19510	COG1509	lysine 2,3-aminomutase activity
LH22_RS19525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH22_RS19530	COG3030	protein affecting phage T7 exclusion by the F plasmid
LH22_RS19540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LH22_RS19550	COG1309	transcriptional regulator
LH22_RS19560	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LH22_RS19600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH22_RS19605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LH22_RS19850	COG0741	lytic transglycosylase activity
LH22_RS19865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LH22_RS19950	COG2197	response regulator
LH22_RS19965	COG2124	cytochrome p450