locus-tag	class	description
LK04_RS00015	COG1971	Probably functions as a manganese efflux pump
LK04_RS00040	COG0601	transmembrane transport
LK04_RS00045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS00060	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK04_RS00070	COG4608	Belongs to the ABC transporter superfamily
LK04_RS00080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS00085	COG0601	transmembrane transport
LK04_RS00090	COG0747	negative chemotaxis
LK04_RS00105	COG2271	Major facilitator Superfamily
LK04_RS00110	COG1802	Transcriptional regulator
LK04_RS00115	COG1063	alcohol dehydrogenase
LK04_RS00125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK04_RS00135	COG0400	carboxylic ester hydrolase activity
LK04_RS00140	COG0435	Glutathione S-transferase
LK04_RS00145	COG0583	DNA-binding transcription factor activity
LK04_RS00155	COG1132	(ABC) transporter
LK04_RS00160	COG1247	-acetyltransferase
LK04_RS00170	COG2271	Major facilitator Superfamily
LK04_RS00175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK04_RS00180	COG3549	Plasmid maintenance system killer
LK04_RS00185	COG3093	addiction module antidote protein HigA
LK04_RS00200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LK04_RS00205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LK04_RS00210	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LK04_RS00215	COG2205	protein histidine kinase activity
LK04_RS00220	COG2862	Uncharacterized protein family, UPF0114
LK04_RS00225	COG0583	DNA-binding transcription factor activity
LK04_RS00230	COG2814	Major facilitator Superfamily
LK04_RS00250	COG3781	membrane
LK04_RS00255	COG1335	isochorismatase
LK04_RS00260	COG0583	DNA-binding transcription factor activity
LK04_RS00285	COG1069	ribulokinase activity
LK04_RS00300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK04_RS00305	COG1234	tRNA 3'-trailer cleavage
LK04_RS00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LK04_RS00325	COG0742	ribosomal rna small subunit methyltransferase
LK04_RS00340	COG0306	phosphate transporter
LK04_RS00345	COG2081	HI0933 family
LK04_RS00360	COG1335	isochorismatase
LK04_RS00365	COG4977	sequence-specific DNA binding
LK04_RS00375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LK04_RS00380	COG5002	protein histidine kinase activity
LK04_RS00380	COG3447	MASE1 domain protein
LK04_RS00380	COG5001	Diguanylate cyclase
LK04_RS00385	COG0113	porphobilinogen synthase activity
LK04_RS00400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK04_RS00405	COG2200	EAL domain
LK04_RS00410	COG0235	Class ii aldolase
LK04_RS00415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LK04_RS00420	COG0628	permease
LK04_RS00425	COG1178	ABC-type Fe3 transport system permease component
LK04_RS00430	COG1840	ABC-type Fe3 transport system, periplasmic component
LK04_RS00435	COG3842	ATPase activity
LK04_RS00455	COG3718	enzyme involved in inositol metabolism
LK04_RS00465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS00475	COG3962	Belongs to the TPP enzyme family
LK04_RS00480	COG0673	inositol 2-dehydrogenase activity
LK04_RS00485	COG1082	Xylose isomerase domain protein TIM barrel
LK04_RS00490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK04_RS00495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK04_RS00505	COG1349	DNA-binding transcription factor activity
LK04_RS00515	COG0058	SHG alpha-glucan phosphorylase activity
LK04_RS00520	COG1640	4-alpha-glucanotransferase
LK04_RS00525	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LK04_RS00525	COG0316	Belongs to the HesB IscA family
LK04_RS00530	COG1040	competence protein
LK04_RS00535	COG2267	carboxylic ester hydrolase activity
LK04_RS00545	COG0366	Alpha amylase catalytic
LK04_RS00550	COG2183	response to ionizing radiation
LK04_RS00555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LK04_RS00575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LK04_RS00580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LK04_RS00585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LK04_RS00590	COG1011	Hydrolase
LK04_RS00600	COG0494	nUDIX hydrolase
LK04_RS00605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LK04_RS00630	COG4796	Type ii and iii secretion system protein
LK04_RS00645	COG3266	domain, Protein
LK04_RS00655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK04_RS00685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK04_RS00690	COG0402	S-adenosylhomocysteine deaminase activity
LK04_RS00695	COG0738	Major facilitator superfamily
LK04_RS00700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK04_RS00705	COG2184	nucleotidyltransferase activity
LK04_RS00720	COG1289	transmembrane transporter activity
LK04_RS00730	COG1765	OsmC-like protein
LK04_RS00735	COG3954	Phosphoribulokinase
LK04_RS00745	COG0429	hydrolase of the alpha beta-hydrolase fold
LK04_RS00755	COG1609	Transcriptional regulator
LK04_RS00760	COG4521	taurine ABC transporter
LK04_RS00770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK04_RS00775	COG2175	clavaminate synthase activity
LK04_RS00780	COG0488	(ABC) transporter
LK04_RS00785	COG2249	NAD(P)H dehydrogenase (quinone) activity
LK04_RS00790	COG0475	glutathione-regulated potassium exporter activity
LK04_RS00790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK04_RS00795	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LK04_RS00800	COG1047	Peptidyl-prolyl cis-trans
LK04_RS00805	COG2900	Belongs to the SlyX family
LK04_RS00810	COG0545	Peptidyl-prolyl cis-trans isomerase
LK04_RS00815	COG2964	Protein conserved in bacteria
LK04_RS00820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LK04_RS00825	COG2923	Belongs to the DsrF TusC family
LK04_RS00835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK04_RS00840	COG0049	tRNA binding
LK04_RS00845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK04_RS00865	COG0051	transcription antitermination factor activity, RNA binding
LK04_RS00875	COG0088	Forms part of the polypeptide exit tunnel
LK04_RS00890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK04_RS00905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK04_RS00915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK04_RS00920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK04_RS00935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK04_RS00940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK04_RS00945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK04_RS00950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK04_RS00955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK04_RS00960	COG1841	ribosomal large subunit assembly
LK04_RS00965	COG0200	Binds to the 23S rRNA
LK04_RS00970	COG0201	protein transport
LK04_RS00975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK04_RS00985	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK04_RS00990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK04_RS01000	COG0203	ribosomal protein L17
LK04_RS01010	COG0789	Transcriptional regulator
LK04_RS01015	COG3036	rescue of stalled ribosome
LK04_RS01020	COG1970	mechanosensitive ion channel activity
LK04_RS01025	COG0569	domain protein
LK04_RS01030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LK04_RS01030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK04_RS01035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK04_RS01045	COG0758	DNA mediated transformation
LK04_RS01070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LK04_RS01110	COG1126	abc transporter atp-binding protein
LK04_RS01115	COG0765	amino acid transport
LK04_RS01120	COG4597	amino acid ABC transporter
LK04_RS01125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS01130	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LK04_RS01140	COG2264	protein methyltransferase activity
LK04_RS01145	COG4145	pantothenate transmembrane transporter activity
LK04_RS01150	COG3924	membrane
LK04_RS01155	COG0439	Biotin carboxylase
LK04_RS01160	COG0511	ligase activity, forming carbon-carbon bonds
LK04_RS01165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LK04_RS01175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK04_RS01180	COG2199	diguanylate cyclase activity
LK04_RS01180	COG2200	EAL domain
LK04_RS01185	COG1077	Cell shape determining protein MreB Mrl
LK04_RS01190	COG1792	Involved in formation and maintenance of cell shape
LK04_RS01195	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LK04_RS01210	COG3164	Protein of unknown function
LK04_RS01215	COG0312	modulator of DNA gyrase
LK04_RS01220	COG0583	DNA-binding transcription factor activity
LK04_RS01230	COG1566	PFAM secretion protein HlyD family protein
LK04_RS01235	COG1289	transmembrane transporter activity
LK04_RS01245	COG2732	(Barnase) inhibitor
LK04_RS01265	COG1438	arginine binding
LK04_RS01270	COG0039	L-malate dehydrogenase activity
LK04_RS01275	COG1511	domain protein
LK04_RS01275	COG3264	Mechanosensitive ion channel
LK04_RS01280	COG0688	phosphatidylethanolamine metabolic process
LK04_RS01285	COG1162	GTPase activity
LK04_RS01315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LK04_RS01315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LK04_RS01320	COG0802	atpase or kinase
LK04_RS01330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LK04_RS01335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK04_RS01340	COG1923	regulation of RNA biosynthetic process
LK04_RS01345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK04_RS01350	COG0330	HflC and HflK could
LK04_RS01355	COG0330	HflC and HflK could
LK04_RS01360	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LK04_RS01365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK04_RS01375	COG0557	exoribonuclease II activity
LK04_RS01380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK04_RS01385	COG1960	acyl-CoA dehydrogenase activity
LK04_RS01395	COG0840	transmembrane signaling receptor activity
LK04_RS01400	COG1073	alpha beta
LK04_RS01420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK04_RS01425	COG0359	binds to the 23S rRNA
LK04_RS01430	COG3061	Opacity-associated protein A
LK04_RS01435	COG0545	Peptidyl-prolyl cis-trans isomerase
LK04_RS01445	COG1218	3'(2'),5'-bisphosphate nucleotidase
LK04_RS01450	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LK04_RS01460	COG1253	flavin adenine dinucleotide binding
LK04_RS01465	COG0729	surface antigen
LK04_RS01470	COG2911	Protein conserved in bacteria
LK04_RS01475	COG2105	PFAM AIG2 family protein
LK04_RS01485	COG2707	UPF0756 membrane protein
LK04_RS01505	COG3423	Transcriptional regulator
LK04_RS01510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LK04_RS01515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK04_RS01525	COG0312	modulator of DNA gyrase
LK04_RS01530	COG3783	Cytochrome b(562)
LK04_RS01560	COG3964	amidohydrolase
LK04_RS01575	COG3711	transcriptional antiterminator
LK04_RS01575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS01580	COG0583	DNA-binding transcription factor activity
LK04_RS01585	COG1741	Belongs to the pirin family
LK04_RS01590	COG2823	Periplasmic or secreted lipoprotein
LK04_RS01595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LK04_RS01600	COG0792	nuclease activity
LK04_RS01605	COG3107	peptidoglycan biosynthetic process
LK04_RS01610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LK04_RS01625	COG2076	Multidrug Resistance protein
LK04_RS01630	COG0435	Glutathione S-transferase
LK04_RS01635	COG2259	Doxx family
LK04_RS01645	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LK04_RS01650	COG4575	ribosome binding
LK04_RS01655	COG1422	Protein of unknown function (DUF1090)
LK04_RS01665	COG0586	Pfam SNARE associated Golgi protein
LK04_RS01670	COG2186	Transcriptional regulator
LK04_RS01675	COG2271	Major facilitator Superfamily
LK04_RS01685	COG0246	Mannitol dehydrogenase
LK04_RS01690	COG2721	sulfolactate sulfo-lyase activity
LK04_RS01695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LK04_RS01705	COG0673	inositol 2-dehydrogenase activity
LK04_RS01710	COG0038	chloride channel
LK04_RS01715	COG1451	nucleotide metabolic process
LK04_RS01720	COG2813	Specifically methylates the guanine in position
LK04_RS01725	COG1902	pentaerythritol trinitrate reductase activity
LK04_RS01725	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK04_RS01730	COG1063	alcohol dehydrogenase
LK04_RS01735	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS01740	COG2610	gluconate transmembrane transporter activity
LK04_RS01750	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LK04_RS01755	COG0659	secondary active sulfate transmembrane transporter activity
LK04_RS01760	COG2199	diguanylate cyclase activity
LK04_RS01765	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK04_RS01770	COG1285	pathogenesis
LK04_RS01815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK04_RS01835	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LK04_RS01840	COG0732	type I restriction modification DNA specificity domain
LK04_RS01850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LK04_RS01875	COG4221	oxidoreductase activity
LK04_RS01900	COG0358	DNA primase activity
LK04_RS01905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LK04_RS01920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LK04_RS01925	COG1968	undecaprenyl-diphosphatase activity
LK04_RS01930	COG0617	tRNA 3'-terminal CCA addition
LK04_RS01935	COG4991	sh3 domain protein
LK04_RS01940	COG3025	triphosphatase activity
LK04_RS01960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK04_RS01965	COG3384	dioxygenase
LK04_RS01970	COG0754	glutathionylspermidine amidase activity
LK04_RS01985	COG0494	nUDIX hydrolase
LK04_RS01990	COG3151	Protein conserved in bacteria
LK04_RS01995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK04_RS02000	COG3150	esterase
LK04_RS02005	COG0187	DNA topoisomerase II activity
LK04_RS02010	COG0583	DNA-binding transcription factor activity
LK04_RS02025	COG0583	DNA-binding transcription factor activity
LK04_RS02035	COG2249	NAD(P)H dehydrogenase (quinone) activity
LK04_RS02050	COG0191	fructose-bisphosphate aldolase activity
LK04_RS02055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS02055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS02060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS02060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS02060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS02070	COG3711	transcriptional antiterminator
LK04_RS02075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK04_RS02085	COG2132	Multicopper oxidase
LK04_RS02090	COG0656	L-ascorbic acid biosynthetic process
LK04_RS02095	COG2207	Transcriptional regulator
LK04_RS02100	COG0586	Pfam SNARE associated Golgi protein
LK04_RS02105	COG0626	cystathionine gamma-synthase activity
LK04_RS02115	COG0848	biopolymer transport protein
LK04_RS02160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK04_RS02170	COG4297	protein containing double-stranded beta helix domain
LK04_RS02175	COG2308	Evidence 4 Homologs of previously reported genes of
LK04_RS02185	COG1305	Transglutaminase-like
LK04_RS02200	COG3842	ATPase activity
LK04_RS02205	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LK04_RS02210	COG1178	ABC-type Fe3 transport system permease component
LK04_RS02215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LK04_RS02220	COG5001	Diguanylate cyclase
LK04_RS02220	COG3300	MHYT domain
LK04_RS02230	COG1528	Iron-storage protein
LK04_RS02235	COG1473	amidohydrolase
LK04_RS02240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LK04_RS02245	COG2823	Periplasmic or secreted lipoprotein
LK04_RS02250	COG4667	esterase of the alpha-beta hydrolase superfamily
LK04_RS02255	COG0084	hydrolase, TatD family'
LK04_RS02260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LK04_RS02270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LK04_RS02285	COG3706	GGDEF domain
LK04_RS02315	COG0789	Transcriptional regulator
LK04_RS02325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK04_RS02325	COG1017	nitric oxide dioxygenase activity
LK04_RS02330	COG0625	glutathione transferase activity
LK04_RS02335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK04_RS02340	COG1486	melibiose metabolic process
LK04_RS02345	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK04_RS02360	COG3539	Fimbrial protein
LK04_RS02375	COG3121	Chaperone
LK04_RS02380	COG3188	usher protein
LK04_RS02420	COG1609	Transcriptional regulator
LK04_RS02425	COG0673	inositol 2-dehydrogenase activity
LK04_RS02445	COG2072	flavoprotein involved in K transport
LK04_RS02460	COG1126	abc transporter atp-binding protein
LK04_RS02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS02470	COG0765	amino acid transport
LK04_RS02475	COG0765	amino acid transport
LK04_RS02495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK04_RS02500	COG1312	Catalyzes the dehydration of D-mannonate
LK04_RS02505	COG2199	diguanylate cyclase activity
LK04_RS02520	COG0583	DNA-binding transcription factor activity
LK04_RS02540	COG0702	epimerase
LK04_RS02545	COG1733	regulation of RNA biosynthetic process
LK04_RS02555	COG2207	Transcriptional regulator
LK04_RS02555	COG3708	Transcriptional regulator
LK04_RS02565	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LK04_RS02575	COG2375	cellular response to nickel ion
LK04_RS02580	COG1695	Transcriptional regulator
LK04_RS02585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LK04_RS02595	COG1811	Na channel or pump
LK04_RS02600	COG0583	DNA-binding transcription factor activity
LK04_RS02615	COG3720	iron ion transport
LK04_RS02620	COG4558	Periplasmic binding protein
LK04_RS02625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK04_RS02630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LK04_RS02635	COG0604	alcohol dehydrogenase
LK04_RS02645	COG1982	Orn Lys Arg decarboxylase major
LK04_RS02650	COG0741	lytic transglycosylase activity
LK04_RS02660	COG1194	a g-specific adenine glycosylase
LK04_RS02670	COG3171	Protein conserved in bacteria
LK04_RS02680	COG3037	sugar-specific permease SgaT UlaA
LK04_RS02690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS02695	COG2188	Transcriptional regulator
LK04_RS02700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LK04_RS02705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK04_RS02710	COG0762	integral membrane protein
LK04_RS02715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LK04_RS02720	COG2805	Type II/IV secretion system protein
LK04_RS02730	COG1678	Uncharacterized ACR, COG1678
LK04_RS02740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LK04_RS02745	COG2356	endonuclease I
LK04_RS02755	COG2814	Major facilitator Superfamily
LK04_RS02760	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK04_RS02765	COG1166	arginine decarboxylase activity
LK04_RS02860	COG3753	Protein conserved in bacteria
LK04_RS02865	COG0501	Belongs to the peptidase M48B family
LK04_RS02870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK04_RS02875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LK04_RS02880	COG0126	phosphoglycerate kinase activity
LK04_RS02885	COG0191	fructose-bisphosphate aldolase activity
LK04_RS02890	COG0668	transmembrane transport
LK04_RS02895	COG1279	arginine transmembrane transporter activity
LK04_RS02910	COG2271	Major facilitator Superfamily
LK04_RS02915	COG2968	Membrane
LK04_RS02920	COG0583	DNA-binding transcription factor activity
LK04_RS02930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK04_RS02935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK04_RS02945	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LK04_RS02950	COG3079	Belongs to the UPF0149 family
LK04_RS02955	COG0006	proline dipeptidase activity
LK04_RS02960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK04_RS02965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK04_RS02980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK04_RS02980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LK04_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS02990	COG2723	6-phospho-beta-galactosidase activity
LK04_RS02995	COG1737	Transcriptional regulator
LK04_RS03000	COG1272	protein, Hemolysin III
LK04_RS03005	COG0354	folic acid binding
LK04_RS03025	COG0716	FMN binding
LK04_RS03030	COG4974	Belongs to the 'phage' integrase family
LK04_RS03035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LK04_RS03040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LK04_RS03050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK04_RS03075	COG0765	amino acid transport
LK04_RS03080	COG4215	(ABC) transporter
LK04_RS03095	COG2814	Major facilitator Superfamily
LK04_RS03100	COG0583	DNA-binding transcription factor activity
LK04_RS03115	COG1609	Transcriptional regulator
LK04_RS03125	COG0768	penicillin binding
LK04_RS03170	COG0204	Acyl-transferase
LK04_RS03170	COG0318	PFAM AMP-dependent synthetase and ligase
LK04_RS03180	COG0667	Aldo Keto reductase
LK04_RS03190	COG0861	Integral membrane protein TerC family
LK04_RS03200	COG1051	belongs to the nudix hydrolase family
LK04_RS03210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK04_RS03215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LK04_RS03225	COG4795	General secretion pathway protein
LK04_RS03240	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LK04_RS03250	COG1074	ATP-dependent DNA helicase activity
LK04_RS03255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK04_RS03260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK04_RS03260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LK04_RS03265	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK04_RS03285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LK04_RS03290	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LK04_RS03295	COG2166	iron-sulfur cluster assembly
LK04_RS03300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK04_RS03310	COG0583	DNA-binding transcription factor activity
LK04_RS03315	COG2363	Small membrane protein
LK04_RS03330	COG1611	Belongs to the LOG family
LK04_RS03350	COG3098	single-species biofilm formation
LK04_RS03355	COG0564	pseudouridine synthase activity
LK04_RS03360	COG0716	FMN binding
LK04_RS03365	COG2721	sulfolactate sulfo-lyase activity
LK04_RS03370	COG2271	Major facilitator Superfamily
LK04_RS03375	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS03380	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS03390	COG2084	Dehydrogenase
LK04_RS03395	COG1929	Belongs to the glycerate kinase type-1 family
LK04_RS03405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK04_RS03410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK04_RS03415	COG3956	TIGRFAM MazG family protein
LK04_RS03420	COG0504	CTP synthase activity
LK04_RS03425	COG0148	phosphopyruvate hydratase activity
LK04_RS03430	COG0602	queuosine metabolic process
LK04_RS03435	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LK04_RS03440	COG0720	synthase
LK04_RS03450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK04_RS03465	COG2234	aminopeptidase activity
LK04_RS03470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK04_RS03470	COG1648	precorrin-2 dehydrogenase activity
LK04_RS03475	COG0175	sulfate reduction
LK04_RS03480	COG2895	sulfate adenylyltransferase (ATP) activity
LK04_RS03495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LK04_RS03500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LK04_RS03510	COG0585	pseudouridine synthase activity
LK04_RS03515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LK04_RS03530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK04_RS03535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LK04_RS03545	COG2951	lytic endotransglycosylase activity
LK04_RS03550	COG2824	Alkylphosphonate utilization operon protein PhnA
LK04_RS03555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK04_RS03560	COG4106	trans-aconitate 2-methyltransferase activity
LK04_RS03565	COG1546	Belongs to the CinA family
LK04_RS03585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LK04_RS03615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK04_RS03620	COG1238	metal cluster binding
LK04_RS03625	COG2918	glutathione biosynthetic process
LK04_RS03630	COG1854	S-ribosylhomocysteine lyase activity
LK04_RS03635	COG4536	flavin adenine dinucleotide binding
LK04_RS03640	COG4137	Cytochrome C assembly protein
LK04_RS03645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LK04_RS03650	COG0228	four-way junction DNA binding
LK04_RS03665	COG0335	large ribosomal subunit rRNA binding
LK04_RS03675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK04_RS03680	COG1605	Chorismate mutase
LK04_RS03680	COG0287	Prephenate dehydrogenase
LK04_RS03685	COG1605	Chorismate mutase
LK04_RS03685	COG0077	Prephenate dehydratase
LK04_RS03690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK04_RS03695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS03700	COG0564	pseudouridine synthase activity
LK04_RS03705	COG1496	oxidoreductase activity
LK04_RS03710	COG0542	response to heat
LK04_RS03740	COG0477	Major facilitator Superfamily
LK04_RS03745	COG5544	Lipoprotein
LK04_RS03750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK04_RS03755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK04_RS03755	COG1042	CoA-binding domain protein
LK04_RS03755	COG0045	succinate-CoA ligase (ADP-forming) activity
LK04_RS03760	COG3148	PFAM DTW domain containing protein
LK04_RS03765	COG3118	belongs to the thioredoxin family
LK04_RS03770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK04_RS03775	COG2814	Major facilitator Superfamily
LK04_RS03780	COG1566	PFAM secretion protein HlyD family protein
LK04_RS03785	COG1846	Transcriptional regulator
LK04_RS03805	COG4175	Glycine betaine
LK04_RS03815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK04_RS03820	COG1780	Probably involved in ribonucleotide reductase function
LK04_RS03825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK04_RS03830	COG4575	ribosome binding
LK04_RS03840	COG0833	amino acid
LK04_RS03845	COG2040	homocysteine
LK04_RS03860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK04_RS03865	COG1116	anion transmembrane transporter activity
LK04_RS03875	COG0444	Belongs to the ABC transporter superfamily
LK04_RS03880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS03885	COG0601	transmembrane transport
LK04_RS03890	COG0747	negative chemotaxis
LK04_RS03905	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LK04_RS03945	COG2867	negative regulation of translational initiation
LK04_RS03955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS03960	COG0497	DNA recombination
LK04_RS03965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK04_RS03970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK04_RS03985	COG0513	Belongs to the DEAD box helicase family
LK04_RS03990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LK04_RS03995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LK04_RS04010	COG3026	antisigma factor binding
LK04_RS04015	COG3086	response to oxidative stress
LK04_RS04025	COG0681	Belongs to the peptidase S26 family
LK04_RS04030	COG0571	ribonuclease III activity
LK04_RS04040	COG1381	Involved in DNA repair and RecF pathway recombination
LK04_RS04045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LK04_RS04050	COG0736	holo-[acyl-carrier-protein] synthase activity
LK04_RS04055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LK04_RS04060	COG1737	Transcriptional regulator
LK04_RS04065	COG0560	Phosphoserine phosphatase
LK04_RS04075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LK04_RS04080	COG0047	phosphoribosylformylglycinamidine synthase activity
LK04_RS04080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK04_RS04085	COG2205	protein histidine kinase activity
LK04_RS04090	COG3170	Tfp pilus assembly protein FimV
LK04_RS04095	COG2204	response regulator
LK04_RS04100	COG0347	Belongs to the P(II) protein family
LK04_RS04105	COG1017	nitric oxide dioxygenase activity
LK04_RS04105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK04_RS04110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK04_RS04115	COG2814	Major facilitator Superfamily
LK04_RS04120	COG3711	transcriptional antiterminator
LK04_RS04130	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LK04_RS04135	COG0483	inositol monophosphate 1-phosphatase activity
LK04_RS04145	COG1959	2 iron, 2 sulfur cluster binding
LK04_RS04155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LK04_RS04165	COG2897	thiosulfate sulfurtransferase activity
LK04_RS04170	COG2373	Large extracellular alpha-helical protein
LK04_RS04175	COG4953	penicillin-binding protein 1C
LK04_RS04180	COG0105	UTP biosynthetic process
LK04_RS04185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK04_RS04190	COG3063	Type IV pilus biogenesis stability protein PilW
LK04_RS04195	COG1426	Protein conserved in bacteria
LK04_RS04200	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK04_RS04205	COG0124	histidyl-tRNA synthetase
LK04_RS04210	COG2976	Protein conserved in bacteria
LK04_RS04215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS04220	COG1160	GTP binding
LK04_RS04225	COG4993	Dehydrogenase
LK04_RS04245	COG1570	exodeoxyribonuclease VII activity
LK04_RS04250	COG0517	IMP dehydrogenase activity
LK04_RS04250	COG0516	GMP reductase activity
LK04_RS04255	COG0519	Catalyzes the synthesis of GMP from XMP
LK04_RS04255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK04_RS04265	COG3657	addiction module killer protein
LK04_RS04285	COG2239	Acts as a magnesium transporter
LK04_RS04295	COG0500	methyltransferase
LK04_RS04305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LK04_RS04310	COG0573	inorganic phosphate transmembrane transporter activity
LK04_RS04320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK04_RS04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LK04_RS04330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK04_RS04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK04_RS04340	COG2233	PERMEase
LK04_RS04345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK04_RS04350	COG1393	Belongs to the ArsC family
LK04_RS04355	COG4783	chaperone-mediated protein folding
LK04_RS04370	COG1609	Transcriptional regulator
LK04_RS04385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LK04_RS04390	COG3842	ATPase activity
LK04_RS04395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LK04_RS04405	COG0628	permease
LK04_RS04410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LK04_RS04415	COG2716	regulation of RNA biosynthetic process
LK04_RS04420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK04_RS04425	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LK04_RS04435	COG2321	neutral zinc metallopeptidase
LK04_RS04440	COG1444	tRNA N-acetyltransferase activity
LK04_RS04445	COG0400	carboxylic ester hydrolase activity
LK04_RS04455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK04_RS04460	COG1393	Belongs to the ArsC family
LK04_RS04470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK04_RS04475	COG2197	response regulator
LK04_RS04480	COG3850	Histidine kinase
LK04_RS04495	COG3062	negative regulation of establishment of protein localization
LK04_RS04500	COG0243	molybdopterin cofactor binding
LK04_RS04505	COG3043	anaerobic respiration
LK04_RS04510	COG3005	denitrification pathway
LK04_RS04515	COG0494	nUDIX hydrolase
LK04_RS04520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS04525	COG1940	carbohydrate kinase activity
LK04_RS04530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK04_RS04540	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS04545	COG1129	ABC transporter
LK04_RS04555	COG1349	DNA-binding transcription factor activity
LK04_RS04560	COG5342	invasion associated locus B
LK04_RS04565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK04_RS04570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK04_RS04575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK04_RS04580	COG0280	phosphate acetyltransferase
LK04_RS04580	COG0281	malic enzyme
LK04_RS04595	COG0456	acetyltransferase
LK04_RS04610	COG2837	iron assimilation
LK04_RS04620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LK04_RS04625	COG4208	sulfate ABC transporter
LK04_RS04630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LK04_RS04635	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LK04_RS04640	COG0745	RESPONSE REGULATOR receiver
LK04_RS04645	COG2205	protein histidine kinase activity
LK04_RS04680	COG3115	cell septum assembly
LK04_RS04690	COG3530	Putative quorum-sensing-regulated virulence factor
LK04_RS04695	COG0385	Bile acid
LK04_RS04700	COG0583	DNA-binding transcription factor activity
LK04_RS04730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK04_RS04735	COG3415	Transposase
LK04_RS04740	COG2116	formate transmembrane transporter activity
LK04_RS04770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS04775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LK04_RS04780	COG1914	H( )-stimulated, divalent metal cation uptake system
LK04_RS04790	COG0667	Aldo Keto reductase
LK04_RS04795	COG3961	Belongs to the TPP enzyme family
LK04_RS04800	COG0837	glucose binding
LK04_RS04805	COG3279	Response regulator of the LytR AlgR family
LK04_RS04810	COG3275	phosphorelay sensor kinase activity
LK04_RS04825	COG0436	Aminotransferase
LK04_RS04860	COG2223	nitrite transmembrane transporter activity
LK04_RS04945	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LK04_RS04970	COG1846	Transcriptional regulator
LK04_RS05000	COG1403	HNH endonuclease
LK04_RS05020	COG3179	chitinase
LK04_RS05045	COG1802	Transcriptional regulator
LK04_RS05045	COG4626	Terminase
LK04_RS05050	COG4695	Portal protein
LK04_RS05055	COG0740	serine-type endopeptidase activity
LK04_RS05090	COG4386	tail sheath protein
LK04_RS05130	COG3299	homolog of phage Mu protein gp47
LK04_RS05135	COG3778	Protein conserved in bacteria
LK04_RS05145	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LK04_RS05165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK04_RS05180	COG2116	formate transmembrane transporter activity
LK04_RS05190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK04_RS05195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK04_RS05200	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LK04_RS05205	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LK04_RS05210	COG1138	Cytochrome C-type biogenesis protein
LK04_RS05225	COG3088	subunit of a heme lyase
LK04_RS05225	COG4235	cytochrome complex assembly
LK04_RS05235	COG0477	Major facilitator Superfamily
LK04_RS05240	COG0583	DNA-binding transcription factor activity
LK04_RS05245	COG2067	long-chain fatty acid transport protein
LK04_RS05250	COG3691	Protein conserved in bacteria
LK04_RS05255	COG0183	Belongs to the thiolase family
LK04_RS05260	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK04_RS05260	COG1024	Enoyl-CoA hydratase
LK04_RS05265	COG2062	phosphohistidine phosphatase, SixA
LK04_RS05280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK04_RS05290	COG0730	response to heat
LK04_RS05295	COG3101	peptidyl-lysine hydroxylation
LK04_RS05310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK04_RS05325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK04_RS05350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LK04_RS05360	COG0586	Pfam SNARE associated Golgi protein
LK04_RS05370	COG0285	dihydrofolate synthase activity
LK04_RS05375	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LK04_RS05380	COG1286	toxin biosynthetic process
LK04_RS05385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LK04_RS05390	COG0163	prenyltransferase activity
LK04_RS05395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS05405	COG4160	amino acid transport
LK04_RS05410	COG4598	ABC transporter
LK04_RS05420	COG0246	Mannitol dehydrogenase
LK04_RS05425	COG1070	Carbohydrate kinase
LK04_RS05435	COG1090	epimerase
LK04_RS05440	COG0625	glutathione transferase activity
LK04_RS05450	COG0857	belongs to the CobB CobQ family
LK04_RS05450	COG0280	phosphate acetyltransferase
LK04_RS05455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK04_RS05460	COG3092	negative regulation of chromosome organization
LK04_RS05470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK04_RS05475	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LK04_RS05480	COG0436	Aminotransferase
LK04_RS05485	COG0583	DNA-binding transcription factor activity
LK04_RS05500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK04_RS05500	COG0649	NAD binding
LK04_RS05520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LK04_RS05530	COG0839	Belongs to the complex I subunit 6 family
LK04_RS05535	COG0713	ATP synthesis coupled electron transport
LK04_RS05540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LK04_RS05545	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK04_RS05550	COG1007	ATP synthesis coupled electron transport
LK04_RS05555	COG2153	protein acetylation
LK04_RS05565	COG4575	ribosome binding
LK04_RS05575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LK04_RS05580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK04_RS05585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK04_RS05590	COG1070	Carbohydrate kinase
LK04_RS05595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LK04_RS05600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK04_RS05610	COG0784	Response regulator, receiver
LK04_RS05610	COG2205	protein histidine kinase activity
LK04_RS05615	COG2197	response regulator
LK04_RS05620	COG2198	Histidine kinase
LK04_RS05620	COG0642	Histidine kinase
LK04_RS05625	COG2223	nitrite transmembrane transporter activity
LK04_RS05655	COG4615	Cyclic peptide transporter
LK04_RS05695	COG1061	Type III restriction enzyme res subunit
LK04_RS05700	COG1187	pseudouridine synthase activity
LK04_RS05705	COG2814	Major facilitator Superfamily
LK04_RS05715	COG4172	Belongs to the ABC transporter superfamily
LK04_RS05720	COG4239	(ABC) transporter, permease
LK04_RS05725	COG4174	ABC transporter (Permease)
LK04_RS05730	COG4166	transmembrane transport
LK04_RS05735	COG2200	EAL domain
LK04_RS05740	COG0791	NLP P60 protein
LK04_RS05745	COG0671	phosphoesterase, PA-phosphatase related
LK04_RS05750	COG0523	cobalamin synthesis protein
LK04_RS05755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK04_RS05760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS05760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS05765	COG1105	Belongs to the carbohydrate kinase PfkB family
LK04_RS05770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LK04_RS05770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS05770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK04_RS05775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LK04_RS05790	COG0583	DNA-binding transcription factor activity
LK04_RS05795	COG0833	amino acid
LK04_RS05800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK04_RS05805	COG1120	ATPase activity
LK04_RS05820	COG0583	DNA-binding transcription factor activity
LK04_RS05825	COG0477	Major facilitator Superfamily
LK04_RS05835	COG2311	Membrane
LK04_RS05860	COG2949	membrane
LK04_RS05865	COG0281	malic enzyme
LK04_RS05870	COG0295	cytidine deaminase activity
LK04_RS05875	COG1346	cytolysis
LK04_RS05880	COG1380	Effector of murein hydrolase LrgA
LK04_RS05885	COG2852	Protein conserved in bacteria
LK04_RS05890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK04_RS05890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK04_RS05895	COG0489	protein tyrosine kinase activity
LK04_RS05930	COG1830	Aldolase
LK04_RS05935	COG1802	Transcriptional regulator
LK04_RS05940	COG0246	Mannitol dehydrogenase
LK04_RS05945	COG2271	Major facilitator Superfamily
LK04_RS05950	COG1063	alcohol dehydrogenase
LK04_RS05975	COG0826	peptidase U32
LK04_RS05980	COG0745	RESPONSE REGULATOR receiver
LK04_RS05985	COG2205	protein histidine kinase activity
LK04_RS05995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK04_RS06005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK04_RS06010	COG0667	Aldo Keto reductase
LK04_RS06020	COG0443	Heat shock 70 kDa protein
LK04_RS06025	COG3447	MASE1 domain protein
LK04_RS06025	COG5002	protein histidine kinase activity
LK04_RS06025	COG5001	Diguanylate cyclase
LK04_RS06035	COG0572	uridine kinase
LK04_RS06040	COG0717	Belongs to the dCTP deaminase family
LK04_RS06045	COG2982	Protein involved in outer membrane biogenesis
LK04_RS06050	COG1253	flavin adenine dinucleotide binding
LK04_RS06080	COG1215	transferase activity, transferring glycosyl groups
LK04_RS06120	COG1088	dTDP-glucose 4,6-dehydratase activity
LK04_RS06125	COG1091	dTDP-4-dehydrorhamnose reductase activity
LK04_RS06140	COG1215	transferase activity, transferring glycosyl groups
LK04_RS06145	COG3754	Rhamnan synthesis protein F
LK04_RS06160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LK04_RS06165	COG1216	Glycosyl transferase, family 2
LK04_RS06165	COG0438	transferase activity, transferring glycosyl groups
LK04_RS06180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK04_RS06205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK04_RS06220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK04_RS06225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LK04_RS06230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LK04_RS06235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK04_RS06255	COG2246	polysaccharide biosynthetic process
LK04_RS06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK04_RS06265	COG1917	Cupin 2, conserved barrel domain protein
LK04_RS06265	COG1396	sequence-specific DNA binding
LK04_RS06270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK04_RS06275	COG0174	glutamine synthetase
LK04_RS06280	COG0531	amino acid
LK04_RS06285	COG1349	DNA-binding transcription factor activity
LK04_RS06290	COG2084	Dehydrogenase
LK04_RS06295	COG3395	kinase activity
LK04_RS06300	COG0235	Class ii aldolase
LK04_RS06305	COG3622	Belongs to the hyi family
LK04_RS06310	COG2610	gluconate transmembrane transporter activity
LK04_RS06315	COG2925	Exonuclease
LK04_RS06325	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LK04_RS06330	COG1289	transmembrane transporter activity
LK04_RS06335	COG2926	Belongs to the UPF0265 family
LK04_RS06340	COG1609	Transcriptional regulator
LK04_RS06345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LK04_RS06350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LK04_RS06360	COG1414	Transcriptional regulator
LK04_RS06365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK04_RS06370	COG2271	Major facilitator Superfamily
LK04_RS06375	COG0477	Major facilitator Superfamily
LK04_RS06380	COG0477	Major facilitator Superfamily
LK04_RS06385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK04_RS06390	COG0747	negative chemotaxis
LK04_RS06395	COG0454	-acetyltransferase
LK04_RS06400	COG0747	negative chemotaxis
LK04_RS06410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS06415	COG4172	Belongs to the ABC transporter superfamily
LK04_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS06435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS06445	COG0583	DNA-binding transcription factor activity
LK04_RS06455	COG1598	PFAM Uncharacterised protein family UPF0150
LK04_RS06485	COG2011	ABC-type metal ion transport system permease component
LK04_RS06520	COG1129	ABC transporter
LK04_RS06525	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS06535	COG0583	DNA-binding transcription factor activity
LK04_RS06545	COG1012	belongs to the aldehyde dehydrogenase family
LK04_RS06555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK04_RS06565	COG0601	transmembrane transport
LK04_RS06570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS06590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK04_RS06595	COG1473	amidohydrolase
LK04_RS06605	COG1522	sequence-specific DNA binding
LK04_RS06625	COG0300	oxidoreductase activity
LK04_RS06630	COG5001	Diguanylate cyclase
LK04_RS06635	COG2188	Transcriptional regulator
LK04_RS06640	COG3624	Phosphonate C-P lyase system protein PhnG
LK04_RS06645	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LK04_RS06650	COG3626	phosphonate metabolism
LK04_RS06655	COG3627	carbon phosphorus lyase activity
LK04_RS06660	COG4107	phosphonate C-P lyase system protein PhnK
LK04_RS06665	COG4778	phosphonate C-P lyase system protein PhnL
LK04_RS06670	COG3454	Phosphonate metabolism
LK04_RS06675	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LK04_RS06680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LK04_RS06690	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LK04_RS06700	COG3639	organic phosphonate transmembrane transporter activity
LK04_RS06710	COG1129	ABC transporter
LK04_RS06715	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS06730	COG0191	fructose-bisphosphate aldolase activity
LK04_RS06745	COG2252	PERMEase
LK04_RS06755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK04_RS06790	COG0534	Mate efflux family protein
LK04_RS06795	COG4774	siderophore transport
LK04_RS06820	COG1418	mRNA catabolic process
LK04_RS06830	COG0840	transmembrane signaling receptor activity
LK04_RS06835	COG0270	DNA (cytosine-5-)-methyltransferase activity
LK04_RS06840	COG3727	T/G mismatch-specific endonuclease activity
LK04_RS06850	COG2354	Protein conserved in bacteria
LK04_RS06855	COG5475	Uncharacterized small protein (DUF2158)
LK04_RS06865	COG1215	transferase activity, transferring glycosyl groups
LK04_RS06885	COG0840	transmembrane signaling receptor activity
LK04_RS06900	COG1987	bacterial-type flagellum assembly
LK04_RS06905	COG1338	Plays a role in the flagellum-specific transport system
LK04_RS06915	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LK04_RS06920	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LK04_RS06925	COG1580	Controls the rotational direction of flagella during chemotaxis
LK04_RS06935	COG2882	bacterial-type flagellum organization
LK04_RS06945	COG1317	bacterial-type flagellum organization
LK04_RS06950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LK04_RS06955	COG1766	The M ring may be actively involved in energy transduction
LK04_RS06960	COG1677	Flagellar hook-basal body complex protein FliE
LK04_RS06970	COG2200	EAL domain
LK04_RS07030	COG1516	flagellar protein fliS
LK04_RS07035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LK04_RS07040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LK04_RS07045	COG1216	Glycosyl transferase, family 2
LK04_RS07045	COG0438	transferase activity, transferring glycosyl groups
LK04_RS07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS07075	COG0765	amino acid transport
LK04_RS07080	COG1126	abc transporter atp-binding protein
LK04_RS07085	COG4763	Acyl-transferase
LK04_RS07090	COG4763	Acyl-transferase
LK04_RS07095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LK04_RS07095	COG0506	proline dehydrogenase activity
LK04_RS07095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LK04_RS07100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK04_RS07120	COG1702	phosphate starvation-inducible protein PhoH
LK04_RS07135	COG0583	DNA-binding transcription factor activity
LK04_RS07170	COG4977	sequence-specific DNA binding
LK04_RS07175	COG3739	integral membrane protein
LK04_RS07180	COG0012	GTP binding
LK04_RS07185	COG0193	aminoacyl-tRNA hydrolase activity
LK04_RS07200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK04_RS07210	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LK04_RS07220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK04_RS07225	COG2890	protein-(glutamine-N5) methyltransferase activity
LK04_RS07235	COG2912	Transglutaminase-like superfamily
LK04_RS07245	COG0387	Pfam Sodium calcium exchanger
LK04_RS07250	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LK04_RS07255	COG0515	serine threonine protein kinase
LK04_RS07295	COG3707	response regulator
LK04_RS07300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LK04_RS07310	COG1116	anion transmembrane transporter activity
LK04_RS07315	COG2146	nitrite reductase [NAD(P)H] activity
LK04_RS07315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LK04_RS07320	COG0243	molybdopterin cofactor binding
LK04_RS07325	COG1648	precorrin-2 dehydrogenase activity
LK04_RS07325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK04_RS07345	COG0018	arginyl-trna synthetase
LK04_RS07350	COG3102	Protein conserved in bacteria
LK04_RS07355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LK04_RS07360	COG3142	Participates in the control of copper homeostasis
LK04_RS07375	COG1280	lysine exporter protein (LysE YggA)
LK04_RS07385	COG2226	methyltransferase
LK04_RS07390	COG1801	Protein of unknown function DUF72
LK04_RS07400	COG0494	nUDIX hydrolase
LK04_RS07405	COG0217	transcriptional regulatory protein
LK04_RS07415	COG0632	four-way junction helicase activity
LK04_RS07420	COG2255	four-way junction helicase activity
LK04_RS07425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK04_RS07435	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LK04_RS07440	COG0739	heme binding
LK04_RS07445	COG1560	Kdo2-lipid A biosynthetic process
LK04_RS07455	COG0469	pyruvate kinase activity
LK04_RS07460	COG1737	Transcriptional regulator
LK04_RS07465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LK04_RS07470	COG0800	Aldolase
LK04_RS07475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LK04_RS07480	COG2979	Protein of unknown function (DUF533)
LK04_RS07485	COG1770	oligopeptidase
LK04_RS07490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK04_RS07500	COG2372	response to copper ion
LK04_RS07505	COG1276	copper resistance
LK04_RS07515	COG4974	Belongs to the 'phage' integrase family
LK04_RS07650	COG4695	Portal protein
LK04_RS07735	COG3008	intermembrane lipid transfer
LK04_RS07740	COG2995	paraquat-inducible protein a
LK04_RS07745	COG1956	GAF domain-containing protein
LK04_RS07750	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LK04_RS07755	COG0793	Belongs to the peptidase S41A family
LK04_RS07760	COG0501	Belongs to the peptidase M48B family
LK04_RS07765	COG2814	Major facilitator Superfamily
LK04_RS07795	COG2226	methyltransferase
LK04_RS07805	COG3716	PTS system mannose fructose sorbose family IID component
LK04_RS07810	COG3715	PTS system
LK04_RS07815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS07815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS07820	COG1253	flavin adenine dinucleotide binding
LK04_RS07825	COG2200	EAL domain
LK04_RS07830	COG1760	l-serine dehydratase
LK04_RS07850	COG0251	oxidation-reduction process
LK04_RS07855	COG1199	ATP-dependent helicase activity
LK04_RS07865	COG3065	identical protein binding
LK04_RS07870	COG0318	PFAM AMP-dependent synthetase and ligase
LK04_RS07875	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LK04_RS07880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LK04_RS07885	COG2894	cell division
LK04_RS07890	COG0850	regulation of cytokinetic process
LK04_RS07900	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK04_RS07915	COG2186	Transcriptional regulator
LK04_RS07920	COG2719	SpoVR family
LK04_RS07925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK04_RS07930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK04_RS07955	COG2718	Belongs to the UPF0229 family
LK04_RS07960	COG2766	serine protein kinase
LK04_RS07965	COG3713	MltA-interacting MipA family protein
LK04_RS07970	COG0656	L-ascorbic acid biosynthetic process
LK04_RS07985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK04_RS07990	COG3139	Protein of unknown function (DUF1315)
LK04_RS07995	COG1335	isochorismatase
LK04_RS08000	COG0252	asparaginase activity
LK04_RS08005	COG0616	signal peptide processing
LK04_RS08010	COG0778	Nitroreductase
LK04_RS08020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK04_RS08030	COG0708	Exodeoxyribonuclease III
LK04_RS08045	COG0788	formyltetrahydrofolate deformylase activity
LK04_RS08050	COG3012	SEC-C Motif Domain Protein
LK04_RS08055	COG1752	Esterase of the alpha-beta hydrolase superfamily
LK04_RS08060	COG0745	RESPONSE REGULATOR receiver
LK04_RS08065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK04_RS08080	COG2916	Histone family protein nucleoid-structuring protein H-NS
LK04_RS08090	COG1012	belongs to the aldehyde dehydrogenase family
LK04_RS08090	COG1454	alcohol dehydrogenase
LK04_RS08095	COG2095	MarC family integral membrane protein
LK04_RS08110	COG0601	transmembrane transport
LK04_RS08115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS08120	COG0444	Belongs to the ABC transporter superfamily
LK04_RS08130	COG3099	Belongs to the UPF0263 family
LK04_RS08135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK04_RS08140	COG2350	Protein conserved in bacteria
LK04_RS08155	COG2917	probably involved in intracellular septation
LK04_RS08170	COG2823	Periplasmic or secreted lipoprotein
LK04_RS08180	COG0133	tryptophan synthase activity
LK04_RS08190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK04_RS08195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK04_RS08195	COG0512	Glutamine amidotransferase of anthranilate synthase
LK04_RS08200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LK04_RS08205	COG0613	PHP domain protein
LK04_RS08210	COG0009	L-threonylcarbamoyladenylate synthase
LK04_RS08225	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LK04_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS08235	COG0616	signal peptide processing
LK04_RS08270	COG0671	phosphoesterase, PA-phosphatase related
LK04_RS08275	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LK04_RS08280	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LK04_RS08290	COG0023	Translation Initiation Factor
LK04_RS08310	COG1024	Enoyl-CoA hydratase
LK04_RS08315	COG5001	Diguanylate cyclase
LK04_RS08325	COG1966	Carbon starvation protein
LK04_RS08330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LK04_RS08335	COG0243	molybdopterin cofactor binding
LK04_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS08340	COG1263	PTS System
LK04_RS08350	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK04_RS08350	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK04_RS08355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LK04_RS08370	COG4171	peptide transport system, permease
LK04_RS08375	COG4168	peptide transport system, permease
LK04_RS08380	COG4166	transmembrane transport
LK04_RS08390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LK04_RS08395	COG1842	Phage shock protein A
LK04_RS08405	COG1983	PspC domain protein
LK04_RS08415	COG3106	COG3106 Predicted ATPase
LK04_RS08420	COG3768	UPF0283 membrane protein
LK04_RS08430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LK04_RS08435	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS08440	COG2866	Carboxypeptidase
LK04_RS08445	COG4166	transmembrane transport
LK04_RS08465	COG0674	pyruvate-flavodoxin oxidoreductase activity
LK04_RS08465	COG1013	pyruvate-flavodoxin oxidoreductase activity
LK04_RS08465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LK04_RS08465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LK04_RS08470	COG1285	pathogenesis
LK04_RS08480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK04_RS08485	COG2911	Protein conserved in bacteria
LK04_RS08495	COG3784	Protein of unknown function (DUF1318)
LK04_RS08505	COG1643	Atp-dependent helicase
LK04_RS08510	COG3591	Belongs to the peptidase S1B family
LK04_RS08520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LK04_RS08525	COG2205	protein histidine kinase activity
LK04_RS08530	COG0745	RESPONSE REGULATOR receiver
LK04_RS08540	COG0531	amino acid
LK04_RS08550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LK04_RS08555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LK04_RS08565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LK04_RS08570	COG2840	Smr protein MutS2
LK04_RS08575	COG0583	DNA-binding transcription factor activity
LK04_RS08585	COG5383	Protein conserved in bacteria
LK04_RS08600	COG0840	transmembrane signaling receptor activity
LK04_RS08610	COG0436	Aminotransferase
LK04_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS08620	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK04_RS08625	COG0747	negative chemotaxis
LK04_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
LK04_RS08690	COG1309	transcriptional regulator
LK04_RS08710	COG2814	Major facilitator Superfamily
LK04_RS08715	COG0583	DNA-binding transcription factor activity
LK04_RS08720	COG1940	carbohydrate kinase activity
LK04_RS08725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK04_RS08730	COG2233	PERMEase
LK04_RS08755	COG0477	Major facilitator Superfamily
LK04_RS08775	COG4221	oxidoreductase activity
LK04_RS08780	COG0402	S-adenosylhomocysteine deaminase activity
LK04_RS08790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LK04_RS08800	COG0339	signal peptide processing
LK04_RS08815	COG0671	phosphoesterase, PA-phosphatase related
LK04_RS08835	COG1070	Carbohydrate kinase
LK04_RS08845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LK04_RS08885	COG1349	DNA-binding transcription factor activity
LK04_RS08915	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS08920	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS08955	COG1129	ABC transporter
LK04_RS08960	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS08965	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS08970	COG1349	DNA-binding transcription factor activity
LK04_RS08980	COG0402	S-adenosylhomocysteine deaminase activity
LK04_RS09000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LK04_RS09020	COG4628	conserved protein (DUF2132)
LK04_RS09025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LK04_RS09040	COG2706	6-phosphogluconolactonase activity
LK04_RS09050	COG2130	NADP-dependent
LK04_RS09055	COG1187	pseudouridine synthase activity
LK04_RS09075	COG1175	transmembrane transport
LK04_RS09080	COG1653	transport
LK04_RS09085	COG3842	ATPase activity
LK04_RS09095	COG2084	Dehydrogenase
LK04_RS09100	COG1082	Xylose isomerase domain protein TIM barrel
LK04_RS09105	COG0149	triose-phosphate isomerase activity
LK04_RS09110	COG2376	Dihydroxyacetone kinase
LK04_RS09120	COG0698	ribose 5-phosphate isomerase
LK04_RS09125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK04_RS09130	COG0095	Lipoate-protein ligase
LK04_RS09140	COG1309	transcriptional regulator
LK04_RS09155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK04_RS09295	COG1280	lysine exporter protein (LysE YggA)
LK04_RS09315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS09340	COG0583	DNA-binding transcription factor activity
LK04_RS09345	COG2814	Major facilitator Superfamily
LK04_RS09355	COG0583	DNA-binding transcription factor activity
LK04_RS09370	COG2271	Major facilitator Superfamily
LK04_RS09380	COG0246	Mannitol dehydrogenase
LK04_RS09390	COG2186	Transcriptional regulator
LK04_RS09395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK04_RS09400	COG1902	pentaerythritol trinitrate reductase activity
LK04_RS09410	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS09415	COG0747	negative chemotaxis
LK04_RS09420	COG0601	transmembrane transport
LK04_RS09435	COG4608	Belongs to the ABC transporter superfamily
LK04_RS09445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK04_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS09470	COG2814	Major facilitator Superfamily
LK04_RS09475	COG0583	DNA-binding transcription factor activity
LK04_RS09490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS09490	COG2213	PTS system mannitol-specific
LK04_RS09515	COG0205	6-phosphofructokinase activity
LK04_RS09520	COG0277	FAD linked oxidase domain protein
LK04_RS09525	COG2353	YceI-like domain
LK04_RS09570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LK04_RS09580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK04_RS09590	COG2084	Dehydrogenase
LK04_RS09595	COG4772	TonB-dependent receptor
LK04_RS09600	COG1335	isochorismatase
LK04_RS09610	COG1396	sequence-specific DNA binding
LK04_RS09615	COG3135	benzoate transporter
LK04_RS09640	COG4290	ribonuclease
LK04_RS09650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK04_RS09660	COG5002	protein histidine kinase activity
LK04_RS09665	COG0745	RESPONSE REGULATOR receiver
LK04_RS09670	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
LK04_RS09675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LK04_RS09700	COG0114	fumarate hydratase activity
LK04_RS09710	COG5339	Protein conserved in bacteria
LK04_RS09715	COG1609	Transcriptional regulator
LK04_RS09720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS09720	COG1263	PTS System
LK04_RS09875	COG3772	lysozyme
LK04_RS09925	COG1846	Transcriptional regulator
LK04_RS09990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK04_RS10005	COG4725	Belongs to the MT-A70-like family
LK04_RS10025	COG0582	viral genome integration into host DNA
LK04_RS10030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS10030	COG1263	PTS System
LK04_RS10035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LK04_RS10040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LK04_RS10045	COG0673	inositol 2-dehydrogenase activity
LK04_RS10055	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS10065	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS10070	COG1069	ribulokinase activity
LK04_RS10075	COG2160	L-arabinose isomerase activity
LK04_RS10085	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS10090	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS10095	COG1129	ABC transporter
LK04_RS10100	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS10115	COG4657	Part of a membrane complex involved in electron transport
LK04_RS10120	COG2878	Part of a membrane complex involved in electron transport
LK04_RS10125	COG4656	Part of a membrane complex involved in electron transport
LK04_RS10130	COG4658	electron transport chain
LK04_RS10135	COG4659	FMN binding
LK04_RS10140	COG4660	Part of a membrane complex involved in electron transport
LK04_RS10145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LK04_RS10150	COG1063	alcohol dehydrogenase
LK04_RS10155	COG0504	CTP synthase activity
LK04_RS10165	COG0583	DNA-binding transcription factor activity
LK04_RS10170	COG0625	glutathione transferase activity
LK04_RS10180	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LK04_RS10195	COG3895	Periplasmic Protein
LK04_RS10200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LK04_RS10210	COG1846	Transcriptional regulator
LK04_RS10220	COG1566	PFAM secretion protein HlyD family protein
LK04_RS10225	COG1289	transmembrane transporter activity
LK04_RS10235	COG2032	superoxide dismutase activity
LK04_RS10240	COG4989	oxidoreductase activity
LK04_RS10245	COG3313	Fe-S protein
LK04_RS10250	COG2194	sulfuric ester hydrolase activity
LK04_RS10255	COG1309	transcriptional regulator
LK04_RS10260	COG1902	pentaerythritol trinitrate reductase activity
LK04_RS10265	COG0346	lactoylglutathione lyase activity
LK04_RS10270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK04_RS10275	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LK04_RS10280	COG0791	NLP P60 protein
LK04_RS10285	COG1609	Transcriptional regulator
LK04_RS10290	COG0583	DNA-binding transcription factor activity
LK04_RS10295	COG2814	Major facilitator Superfamily
LK04_RS10300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LK04_RS10305	COG0307	riboflavin synthase, alpha
LK04_RS10340	COG1376	ErfK ybiS ycfS ynhG family protein
LK04_RS10340	COG1388	LysM domain
LK04_RS10345	COG2166	iron-sulfur cluster assembly
LK04_RS10355	COG0719	Fe-S assembly protein
LK04_RS10360	COG0396	ATPase activity
LK04_RS10365	COG0719	Fe-S assembly protein
LK04_RS10370	COG0316	Belongs to the HesB IscA family
LK04_RS10385	COG0628	permease
LK04_RS10395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK04_RS10395	COG0574	Belongs to the PEP-utilizing enzyme family
LK04_RS10400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LK04_RS10405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK04_RS10410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LK04_RS10420	COG0791	NLP P60 protein
LK04_RS10430	COG0386	Belongs to the glutathione peroxidase family
LK04_RS10435	COG4139	cobalamin transport
LK04_RS10445	COG0776	regulation of translation
LK04_RS10465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK04_RS10475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LK04_RS10480	COG3137	Salt-induced outer membrane protein
LK04_RS10490	COG3001	Fructosamine kinase
LK04_RS10500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK04_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS10515	COG1988	membrane-bound metal-dependent
LK04_RS10520	COG1823	symporter activity
LK04_RS10530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS10535	COG2814	Major facilitator Superfamily
LK04_RS10540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LK04_RS10545	COG0322	excinuclease ABC activity
LK04_RS10550	COG3678	ATP-independent chaperone mediated protein folding
LK04_RS10555	COG2988	succinylglutamate desuccinylase activity
LK04_RS10560	COG3724	N-succinylarginine dihydrolase activity
LK04_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
LK04_RS10595	COG4932	domain protein
LK04_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS10605	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS10610	COG1129	ABC transporter
LK04_RS10620	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS10625	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS10630	COG1349	DNA-binding transcription factor activity
LK04_RS10640	COG0745	RESPONSE REGULATOR receiver
LK04_RS10650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LK04_RS10655	COG0840	transmembrane signaling receptor activity
LK04_RS10660	COG0840	transmembrane signaling receptor activity
LK04_RS10665	COG0840	transmembrane signaling receptor activity
LK04_RS10670	COG0835	chemotaxis
LK04_RS10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK04_RS10755	COG0583	DNA-binding transcription factor activity
LK04_RS10770	COG0625	glutathione transferase activity
LK04_RS10775	COG0583	DNA-binding transcription factor activity
LK04_RS10785	COG1902	pentaerythritol trinitrate reductase activity
LK04_RS10790	COG0668	transmembrane transport
LK04_RS10810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LK04_RS10810	COG0456	acetyltransferase
LK04_RS10845	COG2186	Transcriptional regulator
LK04_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS10855	COG2271	Major facilitator Superfamily
LK04_RS10860	COG1063	alcohol dehydrogenase
LK04_RS10870	COG3729	General stress protein
LK04_RS10875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK04_RS10885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK04_RS10890	COG1116	anion transmembrane transporter activity
LK04_RS10905	COG3290	protein histidine kinase activity
LK04_RS10910	COG4565	transcriptional regulatory protein
LK04_RS10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LK04_RS10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LK04_RS10945	COG0519	Catalyzes the synthesis of GMP from XMP
LK04_RS10945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LK04_RS10950	COG0697	spore germination
LK04_RS10955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LK04_RS10960	COG3381	protein complex oligomerization
LK04_RS10965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LK04_RS10980	COG2801	Transposase and inactivated derivatives
LK04_RS10990	COG4774	siderophore transport
LK04_RS10995	COG2261	transglycosylase associated protein
LK04_RS11000	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LK04_RS11005	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK04_RS11010	COG3958	Transketolase
LK04_RS11015	COG3959	Transketolase, thiamine diphosphate binding domain
LK04_RS11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS11025	COG1129	ABC transporter
LK04_RS11035	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS11040	COG2390	Transcriptional regulator
LK04_RS11050	COG1619	proteins homologs of microcin C7 resistance protein MccF
LK04_RS11115	COG0668	transmembrane transport
LK04_RS11120	COG2246	polysaccharide biosynthetic process
LK04_RS11135	COG0538	isocitrate dehydrogenase activity
LK04_RS11140	COG1187	pseudouridine synthase activity
LK04_RS11155	COG2915	High frequency lysogenization protein hflD homolog
LK04_RS11160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK04_RS11165	COG0745	RESPONSE REGULATOR receiver
LK04_RS11170	COG2205	protein histidine kinase activity
LK04_RS11175	COG2850	peptidyl-arginine hydroxylation
LK04_RS11185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK04_RS11190	COG4591	ABC-type transport system involved in lipoprotein release permease component
LK04_RS11200	COG4591	ABC-type transport system involved in lipoprotein release permease component
LK04_RS11210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LK04_RS11215	COG3134	Outer membrane lipoprotein
LK04_RS11220	COG1252	NADH dehydrogenase
LK04_RS11235	COG0510	thiamine kinase activity
LK04_RS11240	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LK04_RS11245	COG5633	Lipoprotein
LK04_RS11250	COG0537	adenosine 5'-monophosphoramidase activity
LK04_RS11260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LK04_RS11265	COG1263	PTS System
LK04_RS11265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS11270	COG0084	hydrolase, TatD family'
LK04_RS11275	COG0470	DNA polymerase III
LK04_RS11280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK04_RS11285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LK04_RS11290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK04_RS11295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK04_RS11300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK04_RS11315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK04_RS11320	COG0416	fatty acid biosynthetic process
LK04_RS11325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK04_RS11330	COG1399	metal-binding, possibly nucleic acid-binding protein
LK04_RS11345	COG1530	ribonuclease E activity
LK04_RS11360	COG1705	Flagellar rod assembly protein muramidase FlgJ
LK04_RS11360	COG3951	Flagellar rod assembly protein muramidase FlgJ
LK04_RS11385	COG1749	Flagellar hook protein flgE
LK04_RS11390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LK04_RS11395	COG1558	bacterial-type flagellum-dependent cell motility
LK04_RS11420	COG0728	peptidoglycan biosynthetic process
LK04_RS11425	COG0673	inositol 2-dehydrogenase activity
LK04_RS11435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK04_RS11445	COG2999	glutathione oxidoreductase activity
LK04_RS11455	COG0418	dihydroorotase activity
LK04_RS11480	COG3038	cytochrome b561
LK04_RS11485	COG2353	YceI-like domain
LK04_RS11490	COG1054	Belongs to the UPF0176 family
LK04_RS11495	COG1560	Kdo2-lipid A biosynthetic process
LK04_RS11510	COG5645	(Lipo)protein
LK04_RS11515	COG2943	transferase activity, transferring hexosyl groups
LK04_RS11530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK04_RS11545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK04_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS11555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK04_RS11590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK04_RS11605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK04_RS11610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK04_RS11655	COG0659	secondary active sulfate transmembrane transporter activity
LK04_RS11675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK04_RS11685	COG2197	response regulator
LK04_RS11700	COG2197	response regulator
LK04_RS11715	COG1113	amino acid transport
LK04_RS11725	COG1309	transcriptional regulator
LK04_RS11745	COG2267	carboxylic ester hydrolase activity
LK04_RS11750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK04_RS11755	COG2233	PERMEase
LK04_RS11780	COG1012	belongs to the aldehyde dehydrogenase family
LK04_RS11800	COG0670	Belongs to the BI1 family
LK04_RS11805	COG2920	part of a sulfur-relay system
LK04_RS11825	COG1832	CoA-binding protein
LK04_RS11840	COG0210	DNA helicase
LK04_RS11845	COG3304	Inner membrane component domain
LK04_RS11850	COG1289	transmembrane transporter activity
LK04_RS11855	COG3070	regulator of competence-specific genes
LK04_RS11870	COG3120	sequence-specific DNA binding
LK04_RS11875	COG1067	ATP-dependent peptidase activity
LK04_RS11880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK04_RS11885	COG3009	Protein conserved in bacteria
LK04_RS11890	COG3008	intermembrane lipid transfer
LK04_RS11890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LK04_RS11895	COG2995	paraquat-inducible protein a
LK04_RS11900	COG0488	(ABC) transporter
LK04_RS11905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LK04_RS11905	COG0116	Belongs to the methyltransferase superfamily
LK04_RS11910	COG0633	Ferredoxin
LK04_RS11910	COG3217	Mosc domain protein beta barrel domain protein
LK04_RS11920	COG0167	dihydroorotate dehydrogenase activity
LK04_RS11925	COG1216	Glycosyl transferase, family 2
LK04_RS11935	COG1216	Glycosyl transferase, family 2
LK04_RS11940	COG0431	NADPH-dependent FMN reductase
LK04_RS11945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LK04_RS11950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS11955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LK04_RS11965	COG0308	aminopeptidase N
LK04_RS11970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LK04_RS11975	COG0017	Asparaginyl-tRNA synthetase
LK04_RS11985	COG1448	Aminotransferase
LK04_RS11990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK04_RS11995	COG3108	Peptidase M15
LK04_RS12000	COG2989	Protein conserved in bacteria
LK04_RS12010	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LK04_RS12015	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LK04_RS12020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK04_RS12025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LK04_RS12030	COG3173	Aminoglycoside phosphotransferase
LK04_RS12035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LK04_RS12040	COG2835	tetraacyldisaccharide 4'-kinase activity
LK04_RS12045	COG3214	Protein conserved in bacteria
LK04_RS12060	COG2333	competence protein COMEC
LK04_RS12060	COG0658	competence protein
LK04_RS12065	COG0776	regulation of translation
LK04_RS12070	COG0539	negative regulation of cytoplasmic translation
LK04_RS12085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LK04_RS12095	COG1944	ATP diphosphatase activity
LK04_RS12100	COG2116	formate transmembrane transporter activity
LK04_RS12105	COG1882	Formate acetyltransferase
LK04_RS12110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK04_RS12115	COG0477	Major facilitator Superfamily
LK04_RS12120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK04_RS12125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LK04_RS12130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LK04_RS12135	COG3107	peptidoglycan biosynthetic process
LK04_RS12135	COG1674	ftsk spoiiie
LK04_RS12145	COG0492	ferredoxin-NADP+ reductase activity
LK04_RS12150	COG4988	ABC transporter
LK04_RS12155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LK04_RS12160	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LK04_RS12165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK04_RS12170	COG0542	response to heat
LK04_RS12175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LK04_RS12180	COG1278	Cold shock
LK04_RS12185	COG3593	DNA synthesis involved in DNA repair
LK04_RS12190	COG2431	L-lysine efflux transmembrane transporter activity
LK04_RS12195	COG0028	Belongs to the TPP enzyme family
LK04_RS12200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LK04_RS12205	COG3023	N-Acetylmuramoyl-L-alanine amidase
LK04_RS12210	COG0393	Putative heavy-metal-binding
LK04_RS12220	COG1126	abc transporter atp-binding protein
LK04_RS12225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS12230	COG4215	(ABC) transporter
LK04_RS12235	COG4160	amino acid transport
LK04_RS12240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS12245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK04_RS12255	COG1177	transmembrane transport
LK04_RS12260	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK04_RS12265	COG3842	ATPase activity
LK04_RS12270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LK04_RS12285	COG0778	Nitroreductase
LK04_RS12295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK04_RS12315	COG0671	phosphoesterase, PA-phosphatase related
LK04_RS12320	COG1686	Belongs to the peptidase S11 family
LK04_RS12330	COG2133	pyrroloquinoline quinone binding
LK04_RS12345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK04_RS12360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS12375	COG4172	Belongs to the ABC transporter superfamily
LK04_RS12380	COG1446	asparaginase
LK04_RS12385	COG0303	'Molybdopterin
LK04_RS12390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LK04_RS12395	COG0488	(ABC) transporter
LK04_RS12400	COG2916	Histone family protein nucleoid-structuring protein H-NS
LK04_RS12415	COG2814	Major facilitator Superfamily
LK04_RS12420	COG1566	PFAM secretion protein HlyD family protein
LK04_RS12425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LK04_RS12430	COG1321	iron dependent repressor
LK04_RS12455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LK04_RS12465	COG5006	permease, DMT superfamily
LK04_RS12470	COG0783	Belongs to the Dps family
LK04_RS12475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS12480	COG0765	amino acid transport
LK04_RS12485	COG1126	abc transporter atp-binding protein
LK04_RS12490	COG0668	transmembrane transport
LK04_RS12495	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LK04_RS12500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK04_RS12505	COG2986	histidine ammonia-lyase
LK04_RS12535	COG1228	amidohydrolase
LK04_RS12540	COG0402	S-adenosylhomocysteine deaminase activity
LK04_RS12555	COG2986	histidine ammonia-lyase
LK04_RS12560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LK04_RS12565	COG1473	amidohydrolase
LK04_RS12570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK04_RS12580	COG0583	DNA-binding transcription factor activity
LK04_RS12590	COG0371	Dehydrogenase
LK04_RS12600	COG0726	polysaccharide deacetylase
LK04_RS12610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS12620	COG0765	amino acid transport
LK04_RS12625	COG0165	Argininosuccinate lyase
LK04_RS12645	COG0789	Transcriptional regulator
LK04_RS12650	COG1174	glycine betaine transport
LK04_RS12655	COG1125	glycine betaine transport
LK04_RS12660	COG1174	glycine betaine transport
LK04_RS12665	COG1732	Glycine betaine
LK04_RS12670	COG0477	Major facilitator Superfamily
LK04_RS12675	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LK04_RS12690	COG0673	inositol 2-dehydrogenase activity
LK04_RS12720	COG1472	Belongs to the glycosyl hydrolase 3 family
LK04_RS12725	COG0277	FAD linked oxidase domain protein
LK04_RS12730	COG3264	Mechanosensitive ion channel
LK04_RS12730	COG1511	domain protein
LK04_RS12735	COG1686	Belongs to the peptidase S11 family
LK04_RS12745	COG0586	Pfam SNARE associated Golgi protein
LK04_RS12750	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS12755	COG3387	PFAM Glycoside hydrolase 15-related
LK04_RS12760	COG1376	ErfK ybiS ycfS ynhG family protein
LK04_RS12770	COG0306	phosphate transporter
LK04_RS12780	COG0477	Major facilitator Superfamily
LK04_RS12790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LK04_RS12795	COG0513	Belongs to the DEAD box helicase family
LK04_RS12810	COG3568	Endonuclease Exonuclease Phosphatase
LK04_RS12815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK04_RS12820	COG0392	lysyltransferase activity
LK04_RS12825	COG0670	Belongs to the BI1 family
LK04_RS12835	COG0314	molybdopterin synthase activity
LK04_RS12840	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LK04_RS12845	COG0315	cyclic pyranopterin monophosphate synthase activity
LK04_RS12850	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK04_RS12875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK04_RS12880	COG2226	methyltransferase
LK04_RS12900	COG1881	PFAM PEBP family protein
LK04_RS12905	COG2706	6-phosphogluconolactonase activity
LK04_RS12910	COG0561	phosphatase activity
LK04_RS12920	COG4149	molybdate abc transporter
LK04_RS12925	COG0725	ABC transporter, periplasmic molybdate-binding protein
LK04_RS12930	COG2005	Transcriptional regulator
LK04_RS12930	COG3585	molybdate ion transport
LK04_RS12935	COG1119	ATPase activity
LK04_RS12940	COG1085	galactose-1-phosphate uridylyltransferase
LK04_RS12950	COG2017	converts alpha-aldose to the beta-anomer
LK04_RS12955	COG0588	phosphoglycerate mutase activity
LK04_RS12960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK04_RS12970	COG2197	response regulator
LK04_RS12975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS12975	COG2205	protein histidine kinase activity
LK04_RS12980	COG1230	cation diffusion facilitator family transporter
LK04_RS12990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LK04_RS12995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK04_RS13020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LK04_RS13025	COG2885	chlorophyll binding
LK04_RS13035	COG3064	Membrane
LK04_RS13040	COG0848	biopolymer transport protein
LK04_RS13045	COG0811	peptide transport
LK04_RS13050	COG0824	Thioesterase
LK04_RS13055	COG3790	cyd operon protein YbgE
LK04_RS13060	COG4890	Cyd operon protein YbgT
LK04_RS13065	COG1294	oxidase, subunit
LK04_RS13070	COG1271	oxidase subunit
LK04_RS13080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LK04_RS13085	COG0045	succinate-CoA ligase (ADP-forming) activity
LK04_RS13090	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK04_RS13095	COG0567	Dehydrogenase, E1 component
LK04_RS13100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LK04_RS13110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LK04_RS13130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LK04_RS13150	COG1984	allophanate hydrolase subunit 2
LK04_RS13155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LK04_RS13170	COG3272	Protein of unknown function (DUF1722)
LK04_RS13180	COG0745	RESPONSE REGULATOR receiver
LK04_RS13185	COG0033	Phosphoglucomutase
LK04_RS13190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LK04_RS13195	COG0596	Alpha beta hydrolase
LK04_RS13210	COG0735	belongs to the Fur family
LK04_RS13220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK04_RS13225	COG1263	PTS System
LK04_RS13225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS13225	COG2190	(PTS) system
LK04_RS13230	COG0363	glucosamine-6-phosphate deaminase activity
LK04_RS13235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LK04_RS13240	COG1846	Transcriptional regulator
LK04_RS13240	COG1940	carbohydrate kinase activity
LK04_RS13245	COG0647	UMP catabolic process
LK04_RS13250	COG0367	asparagine synthase
LK04_RS13295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LK04_RS13300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK04_RS13305	COG1702	phosphate starvation-inducible protein PhoH
LK04_RS13310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK04_RS13315	COG4535	Mg2 and Co2 transporter CorC
LK04_RS13320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LK04_RS13330	COG0765	amino acid transport
LK04_RS13335	COG0765	amino acid transport
LK04_RS13340	COG1126	abc transporter atp-binding protein
LK04_RS13345	COG2888	peptidyl-tyrosine sulfation
LK04_RS13350	COG0495	leucyl-tRNA aminoacylation
LK04_RS13355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LK04_RS13360	COG1466	dna polymerase III delta subunit
LK04_RS13370	COG0799	negative regulation of ribosome biogenesis
LK04_RS13375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LK04_RS13380	COG0768	penicillin binding
LK04_RS13385	COG0772	Belongs to the SEDS family
LK04_RS13390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LK04_RS13395	COG1686	Belongs to the peptidase S11 family
LK04_RS13410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LK04_RS13415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK04_RS13420	COG1126	abc transporter atp-binding protein
LK04_RS13435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK04_RS13475	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LK04_RS13480	COG2610	gluconate transmembrane transporter activity
LK04_RS13485	COG1454	alcohol dehydrogenase
LK04_RS13495	COG0561	phosphatase activity
LK04_RS13505	COG3813	Protein conserved in bacteria
LK04_RS13510	COG0628	permease
LK04_RS13515	COG0628	permease
LK04_RS13530	COG2205	protein histidine kinase activity
LK04_RS13530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK04_RS13535	COG2197	response regulator
LK04_RS13540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK04_RS13540	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LK04_RS13555	COG3501	Rhs element vgr protein
LK04_RS13570	COG0671	phosphoesterase, PA-phosphatase related
LK04_RS13570	COG2453	phosphatase
LK04_RS13575	COG2267	carboxylic ester hydrolase activity
LK04_RS13585	COG4589	Belongs to the CDS family
LK04_RS13590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK04_RS13655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK04_RS13660	COG2501	S4 domain
LK04_RS13665	COG0215	cysteine-tRNA ligase activity
LK04_RS13670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK04_RS13680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LK04_RS13685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LK04_RS13690	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LK04_RS13695	COG4181	ATPase activity
LK04_RS13700	COG2755	lipolytic protein G-D-S-L family
LK04_RS13705	COG0300	oxidoreductase activity
LK04_RS13710	COG3118	belongs to the thioredoxin family
LK04_RS13715	COG0330	HflC and HflK could
LK04_RS13720	COG1585	Membrane protein implicated in regulation of membrane protease activity
LK04_RS13725	COG0789	Transcriptional regulator
LK04_RS13730	COG2217	Heavy metal translocating P-type atpase
LK04_RS13735	COG3735	TraB family
LK04_RS13755	COG0737	Belongs to the 5'-nucleotidase family
LK04_RS13760	COG2223	nitrite transmembrane transporter activity
LK04_RS13765	COG4651	solute:proton antiporter activity
LK04_RS13765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LK04_RS13770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS13775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LK04_RS13780	COG0563	adenylate kinase activity
LK04_RS13795	COG0326	Molecular chaperone. Has ATPase activity
LK04_RS13800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK04_RS13805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK04_RS13810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LK04_RS13815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK04_RS13820	COG2832	Protein of unknown function (DUF454)
LK04_RS13830	COG2261	transglycosylase associated protein
LK04_RS13835	COG1309	transcriptional regulator
LK04_RS13840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK04_RS13845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LK04_RS13855	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK04_RS13860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK04_RS13890	COG3695	enzyme binding
LK04_RS13895	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LK04_RS13900	COG1946	Acyl-CoA thioesterase
LK04_RS13905	COG0004	ammonium transporteR
LK04_RS13910	COG0347	Belongs to the P(II) protein family
LK04_RS13915	COG1132	(ABC) transporter
LK04_RS13920	COG1132	(ABC) transporter
LK04_RS13925	COG1522	sequence-specific DNA binding
LK04_RS13940	COG4533	DNA binding
LK04_RS13950	COG0824	Thioesterase
LK04_RS13955	COG1555	photosystem II stabilization
LK04_RS13960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK04_RS13965	COG0776	regulation of translation
LK04_RS13990	COG0271	Belongs to the BolA IbaG family
LK04_RS13995	COG3056	Lipoprotein
LK04_RS14000	COG2223	nitrite transmembrane transporter activity
LK04_RS14005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LK04_RS14010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LK04_RS14015	COG1845	cytochrome c oxidase, subunit III
LK04_RS14020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LK04_RS14025	COG0109	protoheme IX farnesyltransferase activity
LK04_RS14030	COG2814	Major facilitator Superfamily
LK04_RS14045	COG3284	Transcriptional regulator
LK04_RS14050	COG1666	GTP binding
LK04_RS14055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LK04_RS14065	COG0301	tRNA thio-modification
LK04_RS14065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK04_RS14075	COG0142	geranyltranstransferase activity
LK04_RS14080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK04_RS14085	COG0667	Aldo Keto reductase
LK04_RS14090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LK04_RS14095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LK04_RS14100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK04_RS14105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LK04_RS14110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK04_RS14110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK04_RS14120	COG1652	LysM domain
LK04_RS14125	COG4238	major outer membrane lipoprotein
LK04_RS14130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK04_RS14135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK04_RS14140	COG1862	Preprotein translocase
LK04_RS14145	COG0343	queuine tRNA-ribosyltransferase activity
LK04_RS14150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LK04_RS14160	COG0483	inositol monophosphate 1-phosphatase activity
LK04_RS14180	COG1114	Component of the transport system for branched-chain amino acids
LK04_RS14185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LK04_RS14195	COG5002	protein histidine kinase activity
LK04_RS14200	COG0745	RESPONSE REGULATOR receiver
LK04_RS14205	COG0420	3'-5' exonuclease activity
LK04_RS14210	COG0419	ATPase involved in DNA repair
LK04_RS14235	COG1940	carbohydrate kinase activity
LK04_RS14240	COG2974	May be involved in recombination
LK04_RS14245	COG3123	guanosine phosphorylase activity
LK04_RS14250	COG4126	flavin adenine dinucleotide binding
LK04_RS14265	COG1414	Transcriptional regulator
LK04_RS14275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK04_RS14280	COG3416	Protein conserved in bacteria
LK04_RS14285	COG1671	Belongs to the UPF0178 family
LK04_RS14290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK04_RS14315	COG3250	beta-galactosidase activity
LK04_RS14340	COG3300	MHYT domain
LK04_RS14340	COG5001	Diguanylate cyclase
LK04_RS14350	COG1609	Transcriptional regulator
LK04_RS14360	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK04_RS14365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK04_RS14385	COG1764	response to oxidative stress
LK04_RS14390	COG1304	FMN binding
LK04_RS14395	COG2186	Transcriptional regulator
LK04_RS14405	COG2807	transmembrane transport
LK04_RS14410	COG0583	DNA-binding transcription factor activity
LK04_RS14415	COG0402	S-adenosylhomocysteine deaminase activity
LK04_RS14430	COG0513	Belongs to the DEAD box helicase family
LK04_RS14435	COG0835	chemotaxis
LK04_RS14435	COG0784	Response regulator, receiver
LK04_RS14440	COG0840	transmembrane signaling receptor activity
LK04_RS14445	COG0814	amino acid
LK04_RS14450	COG1215	transferase activity, transferring glycosyl groups
LK04_RS14460	COG0583	DNA-binding transcription factor activity
LK04_RS14490	COG0738	Major facilitator superfamily
LK04_RS14495	COG3254	rhamnose metabolic process
LK04_RS14500	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS14510	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS14515	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK04_RS14560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK04_RS14565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK04_RS14570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LK04_RS14580	COG1073	alpha beta
LK04_RS14585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LK04_RS14590	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK04_RS14595	COG1129	ABC transporter
LK04_RS14600	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS14615	COG3034	peptidoglycan biosynthetic process
LK04_RS14620	COG0121	glutamine amidotransferase
LK04_RS14625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LK04_RS14630	COG1960	acyl-CoA dehydrogenase activity
LK04_RS14635	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LK04_RS14650	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LK04_RS14660	COG0436	Aminotransferase
LK04_RS14665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK04_RS14670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LK04_RS14675	COG2351	hydroxyisourate hydrolase activity
LK04_RS14690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LK04_RS14700	COG0765	amino acid transport
LK04_RS14755	COG1953	Uracil, thiamine, allantoin
LK04_RS14770	COG0328	RNA-DNA hybrid ribonuclease activity
LK04_RS14775	COG2226	methyltransferase
LK04_RS14780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK04_RS14785	COG1388	LysM domain
LK04_RS14785	COG0741	lytic transglycosylase activity
LK04_RS14790	COG3021	interspecies interaction between organisms
LK04_RS14795	COG2814	Major facilitator Superfamily
LK04_RS14800	COG0583	DNA-binding transcription factor activity
LK04_RS14805	COG0656	L-ascorbic acid biosynthetic process
LK04_RS14835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LK04_RS14845	COG2011	ABC-type metal ion transport system permease component
LK04_RS14860	COG1720	tRNA m6t6A37 methyltransferase activity
LK04_RS14865	COG0442	prolyl-tRNA aminoacylation
LK04_RS14870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LK04_RS14880	COG4568	rho-dependent transcription termination
LK04_RS14890	COG0037	tRNA processing
LK04_RS14895	COG0346	lactoylglutathione lyase activity
LK04_RS14900	COG1982	Orn Lys Arg decarboxylase major
LK04_RS14905	COG0825	malonyl-CoA metabolic process
LK04_RS14915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK04_RS14920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK04_RS14930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK04_RS14945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS14955	COG0575	Belongs to the CDS family
LK04_RS14960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK04_RS14965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK04_RS14970	COG0233	cytoplasmic translational termination
LK04_RS14975	COG0528	UMP kinase activity
LK04_RS14980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK04_RS14995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LK04_RS15010	COG2186	Transcriptional regulator
LK04_RS15020	COG3835	regulator
LK04_RS15025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK04_RS15030	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LK04_RS15035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK04_RS15050	COG0316	Belongs to the HesB IscA family
LK04_RS15055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LK04_RS15060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK04_RS15065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK04_RS15070	COG1120	ATPase activity
LK04_RS15075	COG4774	siderophore transport
LK04_RS15080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK04_RS15085	COG1643	Atp-dependent helicase
LK04_RS15090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LK04_RS15095	COG1489	DNA binding
LK04_RS15105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK04_RS15115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LK04_RS15125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK04_RS15130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LK04_RS15140	COG0842	Transport permease protein
LK04_RS15145	COG1131	(ABC) transporter
LK04_RS15160	COG2132	Multicopper oxidase
LK04_RS15170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK04_RS15180	COG1349	DNA-binding transcription factor activity
LK04_RS15185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LK04_RS15190	COG3395	kinase activity
LK04_RS15200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK04_RS15205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK04_RS15210	COG2271	Major facilitator Superfamily
LK04_RS15215	COG2271	Major facilitator Superfamily
LK04_RS15260	COG0667	Aldo Keto reductase
LK04_RS15265	COG0583	DNA-binding transcription factor activity
LK04_RS15270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK04_RS15275	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK04_RS15280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LK04_RS15295	COG1113	amino acid transport
LK04_RS15300	COG2211	Major facilitator Superfamily
LK04_RS15305	COG3940	Belongs to the glycosyl hydrolase 43 family
LK04_RS15310	COG3725	Membrane protein required for beta-lactamase induction
LK04_RS15315	COG3023	N-Acetylmuramoyl-L-alanine amidase
LK04_RS15320	COG0157	Belongs to the NadC ModD family
LK04_RS15325	COG4969	Belongs to the N-Me-Phe pilin family
LK04_RS15330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LK04_RS15335	COG1459	type II secretion system
LK04_RS15340	COG0516	GMP reductase activity
LK04_RS15345	COG0237	dephospho-CoA kinase activity
LK04_RS15355	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LK04_RS15360	COG0494	nUDIX hydrolase
LK04_RS15375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LK04_RS15380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK04_RS15385	COG0849	cell division
LK04_RS15395	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK04_RS15400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK04_RS15410	COG0772	Belongs to the SEDS family
LK04_RS15425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK04_RS15430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK04_RS15435	COG0768	penicillin binding
LK04_RS15450	COG2001	Belongs to the MraZ family
LK04_RS15465	COG0028	Belongs to the TPP enzyme family
LK04_RS15470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK04_RS15480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK04_RS15490	COG2814	Major facilitator Superfamily
LK04_RS15500	COG4143	(ABC) transporter
LK04_RS15505	COG1178	ABC-type Fe3 transport system permease component
LK04_RS15515	COG0586	Pfam SNARE associated Golgi protein
LK04_RS15520	COG0417	DNA replication proofreading
LK04_RS15525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK04_RS15530	COG0564	pseudouridine synthase activity
LK04_RS15545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK04_RS15550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LK04_RS15555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK04_RS15560	COG2967	ApaG domain
LK04_RS15565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK04_RS15570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LK04_RS15585	COG0505	Belongs to the CarA family
LK04_RS15590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK04_RS15595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LK04_RS15600	COG1047	Peptidyl-prolyl cis-trans
LK04_RS15605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK04_RS15610	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK04_RS15615	COG0196	riboflavin kinase activity
LK04_RS15620	COG0268	Binds directly to 16S ribosomal RNA
LK04_RS15625	COG0583	DNA-binding transcription factor activity
LK04_RS15640	COG0443	Heat shock 70 kDa protein
LK04_RS15650	COG0521	Mo-molybdopterin cofactor biosynthetic process
LK04_RS15660	COG3022	response to hydroperoxide
LK04_RS15695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK04_RS15705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK04_RS15710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LK04_RS15815	COG0527	aspartate kinase activity
LK04_RS15815	COG0460	homoserine dehydrogenase
LK04_RS15820	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LK04_RS15825	COG0745	RESPONSE REGULATOR receiver
LK04_RS15830	COG3045	CreA protein
LK04_RS15835	COG2207	Transcriptional regulator
LK04_RS15835	COG3708	Transcriptional regulator
LK04_RS15840	COG0406	alpha-ribazole phosphatase activity
LK04_RS15845	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LK04_RS15855	COG0741	lytic transglycosylase activity
LK04_RS15860	COG2801	Transposase and inactivated derivatives
LK04_RS15875	COG0439	Biotin carboxylase
LK04_RS15880	COG1802	Transcriptional regulator
LK04_RS15900	COG0411	ABC transporter
LK04_RS15910	COG0840	transmembrane signaling receptor activity
LK04_RS15920	COG0738	Major facilitator superfamily
LK04_RS15925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS15930	COG1349	DNA-binding transcription factor activity
LK04_RS15935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK04_RS15940	COG0488	(ABC) transporter
LK04_RS15955	COG0560	Phosphoserine phosphatase
LK04_RS15960	COG3726	membrane protein affecting hemolysin expression
LK04_RS15965	COG3550	peptidyl-serine autophosphorylation
LK04_RS15970	COG1011	Hydrolase
LK04_RS15975	COG0456	acetyltransferase
LK04_RS15980	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LK04_RS15985	COG2813	Specifically methylates the guanine in position
LK04_RS16020	COG4114	ferric iron reductase
LK04_RS16025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK04_RS16030	COG2814	Major facilitator Superfamily
LK04_RS16040	COG1609	Transcriptional regulator
LK04_RS16045	COG0477	Major facilitator Superfamily
LK04_RS16070	COG1942	4-Oxalocrotonate Tautomerase
LK04_RS16080	COG0531	amino acid
LK04_RS16110	COG1464	Belongs to the NlpA lipoprotein family
LK04_RS16120	COG3318	Belongs to the UPF0149 family
LK04_RS16120	COG3012	SEC-C Motif Domain Protein
LK04_RS16130	COG0583	DNA-binding transcription factor activity
LK04_RS16135	COG2249	NAD(P)H dehydrogenase (quinone) activity
LK04_RS16195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LK04_RS16200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK04_RS16235	COG0433	COG0433 Predicted ATPase
LK04_RS16240	COG2733	membrane
LK04_RS16245	COG0795	lipopolysaccharide-transporting ATPase activity
LK04_RS16250	COG0795	lipopolysaccharide-transporting ATPase activity
LK04_RS16255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LK04_RS16260	COG2927	DNA polymerase III (CHI subunit)
LK04_RS16280	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LK04_RS16285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK04_RS16295	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LK04_RS16305	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LK04_RS16320	COG0701	Predicted permease
LK04_RS16325	COG3787	Belongs to the UPF0306 family
LK04_RS16335	COG3153	acetyltransferase
LK04_RS16340	COG3154	lipid carrier protein
LK04_RS16345	COG0826	peptidase U32
LK04_RS16350	COG0826	peptidase U32
LK04_RS16355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LK04_RS16360	COG2207	Transcriptional regulator
LK04_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS16370	COG0513	Belongs to the DEAD box helicase family
LK04_RS16380	COG1185	polyribonucleotide nucleotidyltransferase activity
LK04_RS16385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LK04_RS16390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK04_RS16395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK04_RS16405	COG0195	Participates in both transcription termination and antitermination
LK04_RS16410	COG0779	Required for maturation of 30S ribosomal subunits
LK04_RS16425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK04_RS16430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK04_RS16435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK04_RS16445	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LK04_RS16450	COG1534	Rna-binding protein
LK04_RS16460	COG2027	D-alanyl-D-alanine carboxypeptidase
LK04_RS16465	COG0745	RESPONSE REGULATOR receiver
LK04_RS16470	COG0642	Histidine kinase
LK04_RS16475	COG4771	TonB-dependent receptor
LK04_RS16480	COG2382	esterase
LK04_RS16485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LK04_RS16485	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LK04_RS16490	COG1120	ATPase activity
LK04_RS16495	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK04_RS16500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK04_RS16505	COG0477	Major facilitator Superfamily
LK04_RS16510	COG4592	Periplasmic binding protein
LK04_RS16515	COG1169	isochorismate synthase
LK04_RS16520	COG1021	2,3-dihydroxybenzoate-AMP ligase
LK04_RS16525	COG3433	isochorismatase activity
LK04_RS16525	COG1535	isochorismatase
LK04_RS16530	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS16540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK04_RS16545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK04_RS16550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK04_RS16555	COG0142	geranyltranstransferase activity
LK04_RS16560	COG3423	Transcriptional regulator
LK04_RS16570	COG5007	Belongs to the BolA IbaG family
LK04_RS16575	COG3113	response to antibiotic
LK04_RS16580	COG2854	intermembrane phospholipid transfer
LK04_RS16585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LK04_RS16590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK04_RS16595	COG1127	ABC transporter
LK04_RS16600	COG0530	calcium, potassium:sodium antiporter activity
LK04_RS16605	COG0517	IMP dehydrogenase activity
LK04_RS16605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LK04_RS16610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LK04_RS16615	COG3117	lipopolysaccharide transmembrane transporter activity
LK04_RS16620	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LK04_RS16625	COG1137	ATPase activity
LK04_RS16630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LK04_RS16635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK04_RS16650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS16660	COG5002	protein histidine kinase activity
LK04_RS16660	COG2198	Histidine kinase
LK04_RS16660	COG0784	Response regulator, receiver
LK04_RS16665	COG0070	glutamate synthase
LK04_RS16665	COG0069	glutamate synthase activity
LK04_RS16665	COG0067	glutamate synthase
LK04_RS16670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LK04_RS16675	COG2969	positive regulation of protein catabolic process
LK04_RS16680	COG0625	glutathione transferase activity
LK04_RS16685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK04_RS16695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LK04_RS16700	COG3105	Protein conserved in bacteria
LK04_RS16705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK04_RS16710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK04_RS16715	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LK04_RS16720	COG5510	response to toxic substance
LK04_RS16730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK04_RS16735	COG1509	lysine 2,3-aminomutase activity
LK04_RS16750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LK04_RS16755	COG3030	protein affecting phage T7 exclusion by the F plasmid
LK04_RS16765	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LK04_RS16775	COG1309	transcriptional regulator
LK04_RS16795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LK04_RS16800	COG0697	spore germination
LK04_RS16815	COG1984	allophanate hydrolase subunit 2
LK04_RS16820	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LK04_RS16840	COG4221	oxidoreductase activity
LK04_RS16850	COG0765	amino acid transport
LK04_RS16860	COG0673	inositol 2-dehydrogenase activity
LK04_RS16880	COG1082	Xylose isomerase domain protein TIM barrel
LK04_RS16885	COG0673	inositol 2-dehydrogenase activity
LK04_RS16895	COG0625	glutathione transferase activity
LK04_RS16905	COG0840	transmembrane signaling receptor activity
LK04_RS16930	COG0673	inositol 2-dehydrogenase activity
LK04_RS16940	COG0300	oxidoreductase activity
LK04_RS16955	COG0583	DNA-binding transcription factor activity
LK04_RS16960	COG0473	3-isopropylmalate dehydrogenase activity
LK04_RS16965	COG0395	ABC-type sugar transport system, permease component
LK04_RS16970	COG1175	transmembrane transport
LK04_RS16995	COG1940	carbohydrate kinase activity
LK04_RS17020	COG4993	Dehydrogenase
LK04_RS17025	COG2814	Major facilitator Superfamily
LK04_RS17035	COG4977	sequence-specific DNA binding
LK04_RS17045	COG0642	Histidine kinase
LK04_RS17050	COG3248	Nucleoside-binding outer membrane protein
LK04_RS17055	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LK04_RS17060	COG0583	DNA-binding transcription factor activity
LK04_RS17070	COG1473	amidohydrolase
LK04_RS17075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK04_RS17080	COG2271	Major facilitator Superfamily
LK04_RS17085	COG2856	Zn peptidase
LK04_RS17105	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LK04_RS17130	COG2207	Transcriptional regulator
LK04_RS17135	COG0840	transmembrane signaling receptor activity
LK04_RS17145	COG1263	PTS System
LK04_RS17145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS17150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LK04_RS17160	COG1301	dicarboxylic acid transport
LK04_RS17165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LK04_RS17170	COG3162	membrane
LK04_RS17175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK04_RS17190	COG1346	cytolysis
LK04_RS17200	COG0583	DNA-binding transcription factor activity
LK04_RS17205	COG0025	NhaP-type Na H and K H
LK04_RS17210	COG2252	PERMEase
LK04_RS17220	COG0789	Transcriptional regulator
LK04_RS17225	COG2207	Transcriptional regulator
LK04_RS17250	COG0697	spore germination
LK04_RS17255	COG4977	sequence-specific DNA binding
LK04_RS17255	COG1917	Cupin 2, conserved barrel domain protein
LK04_RS17265	COG0629	single-stranded DNA binding
LK04_RS17275	COG1064	alcohol dehydrogenase
LK04_RS17280	COG2315	Protein conserved in bacteria
LK04_RS17285	COG1448	Aminotransferase
LK04_RS17315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LK04_RS17325	COG0735	belongs to the Fur family
LK04_RS17335	COG0534	Mate efflux family protein
LK04_RS17345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LK04_RS17360	COG3161	chorismate lyase activity
LK04_RS17365	COG3223	Belongs to the PsiE family
LK04_RS17385	COG4149	molybdate abc transporter
LK04_RS17395	COG3842	ATPase activity
LK04_RS17405	COG2610	gluconate transmembrane transporter activity
LK04_RS17410	COG3265	gluconokinase activity
LK04_RS17415	COG1609	Transcriptional regulator
LK04_RS17420	COG1741	Belongs to the pirin family
LK04_RS17425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK04_RS17430	COG1247	-acetyltransferase
LK04_RS17435	COG0405	Gamma-glutamyltransferase
LK04_RS17445	COG0584	glycerophosphoryl diester phosphodiesterase
LK04_RS17465	COG1653	transport
LK04_RS17475	COG0411	ABC transporter
LK04_RS17490	COG0683	leucine binding
LK04_RS17500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK04_RS17505	COG2177	Part of the ABC transporter FtsEX involved in
LK04_RS17510	COG2884	Cell division ATP-binding protein ftsE
LK04_RS17515	COG0552	protein localization to endoplasmic reticulum
LK04_RS17520	COG0742	ribosomal rna small subunit methyltransferase
LK04_RS17525	COG3776	membrane
LK04_RS17535	COG3714	YhhN family
LK04_RS17545	COG0425	Belongs to the sulfur carrier protein TusA family
LK04_RS17550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LK04_RS17560	COG0058	SHG alpha-glucan phosphorylase activity
LK04_RS17565	COG0297	glycogen (starch) synthase activity
LK04_RS17575	COG1523	belongs to the glycosyl hydrolase 13 family
LK04_RS17590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LK04_RS17595	COG2095	MarC family integral membrane protein
LK04_RS17625	COG0527	aspartate kinase activity
LK04_RS17630	COG0166	Belongs to the GPI family
LK04_RS17650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK04_RS17655	COG1410	methionine synthase
LK04_RS17655	COG0646	methionine synthase
LK04_RS17675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LK04_RS17680	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LK04_RS17730	COG3068	Protein conserved in bacteria
LK04_RS17735	COG1515	deoxyribonuclease V activity
LK04_RS17740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LK04_RS17745	COG2816	NAD+ diphosphatase activity
LK04_RS17750	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LK04_RS17755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK04_RS17760	COG0352	thiamine-phosphate diphosphorylase activity
LK04_RS17765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK04_RS17770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK04_RS17775	COG0085	RNA polymerase activity
LK04_RS17785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LK04_RS17795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK04_RS17800	COG0250	Participates in transcription elongation, termination and antitermination
LK04_RS17805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK04_RS17845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LK04_RS17845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LK04_RS17850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK04_RS17885	COG1739	Uncharacterized protein family UPF0029
LK04_RS17890	COG0006	proline dipeptidase activity
LK04_RS17925	COG0084	hydrolase, TatD family'
LK04_RS17930	COG0805	protein transport
LK04_RS17945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LK04_RS17950	COG3165	ubiquinone biosynthetic process from chorismate
LK04_RS17955	COG2226	methyltransferase
LK04_RS17960	COG1322	Protein conserved in bacteria
LK04_RS17975	COG0412	Dienelactone hydrolase
LK04_RS17980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LK04_RS17985	COG0583	DNA-binding transcription factor activity
LK04_RS17990	COG4807	Protein conserved in bacteria
LK04_RS18000	COG2271	Major facilitator Superfamily
LK04_RS18005	COG0561	phosphatase activity
LK04_RS18010	COG2267	carboxylic ester hydrolase activity
LK04_RS18015	COG1280	lysine exporter protein (LysE YggA)
LK04_RS18020	COG1280	lysine exporter protein (LysE YggA)
LK04_RS18035	COG2050	protein possibly involved in aromatic compounds catabolism
LK04_RS18040	COG2962	Rard protein
LK04_RS18045	COG3180	Ammonia monooxygenase
LK04_RS18055	COG0210	DNA helicase
LK04_RS18060	COG1011	Hydrolase
LK04_RS18075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK04_RS18090	COG0181	hydroxymethylbilane synthase activity
LK04_RS18100	COG2959	enzyme of heme biosynthesis
LK04_RS18105	COG3071	HemY protein
LK04_RS18140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK04_RS18145	COG2244	polysaccharide biosynthetic process
LK04_RS18150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LK04_RS18155	COG0456	acetyltransferase
LK04_RS18160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LK04_RS18165	COG1088	dTDP-glucose 4,6-dehydratase activity
LK04_RS18170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LK04_RS18180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LK04_RS18185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK04_RS18190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LK04_RS18195	COG3118	belongs to the thioredoxin family
LK04_RS18200	COG0513	Belongs to the DEAD box helicase family
LK04_RS18205	COG0248	Ppx GppA phosphatase
LK04_RS18210	COG0210	DNA helicase
LK04_RS18215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK04_RS18220	COG2982	Protein involved in outer membrane biogenesis
LK04_RS18225	COG2200	EAL domain
LK04_RS18230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS18240	COG0612	Peptidase, M16
LK04_RS18250	COG2200	EAL domain
LK04_RS18250	COG2199	diguanylate cyclase activity
LK04_RS18255	COG2194	sulfuric ester hydrolase activity
LK04_RS18285	COG1215	transferase activity, transferring glycosyl groups
LK04_RS18290	COG0457	Tetratricopeptide repeat
LK04_RS18290	COG3118	belongs to the thioredoxin family
LK04_RS18295	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LK04_RS18310	COG1215	transferase activity, transferring glycosyl groups
LK04_RS18315	COG1215	transferase activity, transferring glycosyl groups
LK04_RS18320	COG0489	protein tyrosine kinase activity
LK04_RS18330	COG4608	Belongs to the ABC transporter superfamily
LK04_RS18335	COG0444	Belongs to the ABC transporter superfamily
LK04_RS18340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS18345	COG0601	transmembrane transport
LK04_RS18350	COG0747	negative chemotaxis
LK04_RS18365	COG2194	sulfuric ester hydrolase activity
LK04_RS18370	COG1764	response to oxidative stress
LK04_RS18375	COG1846	Transcriptional regulator
LK04_RS18385	COG2944	sequence-specific DNA binding
LK04_RS18390	COG0439	Biotin carboxylase
LK04_RS18405	COG1116	anion transmembrane transporter activity
LK04_RS18425	COG0444	Belongs to the ABC transporter superfamily
LK04_RS18430	COG4608	Belongs to the ABC transporter superfamily
LK04_RS18435	COG0747	negative chemotaxis
LK04_RS18445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS18460	COG2213	PTS system mannitol-specific
LK04_RS18460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK04_RS18470	COG3722	fumarate hydratase activity
LK04_RS18480	COG2990	Protein conserved in bacteria
LK04_RS18485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK04_RS18490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LK04_RS18495	COG1349	DNA-binding transcription factor activity
LK04_RS18505	COG2801	Transposase and inactivated derivatives
LK04_RS18515	COG0243	molybdopterin cofactor binding
LK04_RS18515	COG3383	formate dehydrogenase (NAD+) activity
LK04_RS18520	COG3383	formate dehydrogenase (NAD+) activity
LK04_RS18520	COG0243	molybdopterin cofactor binding
LK04_RS18525	COG0437	4 iron, 4 sulfur cluster binding
LK04_RS18530	COG2864	formate dehydrogenase
LK04_RS18540	COG0625	glutathione transferase activity
LK04_RS18545	COG1921	L-seryl-tRNASec selenium transferase activity
LK04_RS18550	COG3276	selenocysteine insertion sequence binding
LK04_RS18565	COG0751	glycine-tRNA ligase activity
LK04_RS18575	COG0251	oxidation-reduction process
LK04_RS18590	COG1126	abc transporter atp-binding protein
LK04_RS18605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK04_RS18610	COG1802	Transcriptional regulator
LK04_RS18615	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS18620	COG3274	enterobacterial common antigen metabolic process
LK04_RS18630	COG1070	Carbohydrate kinase
LK04_RS18635	COG2115	Belongs to the xylose isomerase family
LK04_RS18640	COG4213	ABC transporter substrate-binding protein
LK04_RS18650	COG4214	carbohydrate transport
LK04_RS18655	COG1609	Transcriptional regulator
LK04_RS18655	COG2207	Transcriptional regulator
LK04_RS18705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LK04_RS18710	COG2252	PERMEase
LK04_RS18715	COG2091	lysine biosynthetic process via aminoadipic acid
LK04_RS18720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LK04_RS18725	COG0840	transmembrane signaling receptor activity
LK04_RS18730	COG0778	Nitroreductase
LK04_RS18735	COG3550	peptidyl-serine autophosphorylation
LK04_RS18750	COG0706	membrane insertase activity
LK04_RS18755	COG0594	ribonuclease P activity
LK04_RS18760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK04_RS18765	COG0592	DNA-directed DNA polymerase activity
LK04_RS18770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK04_RS18780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS18785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK04_RS18795	COG2271	Major facilitator Superfamily
LK04_RS18800	COG0561	phosphatase activity
LK04_RS18805	COG2186	Transcriptional regulator
LK04_RS18810	COG3734	2-keto-3-deoxy-galactonokinase
LK04_RS18815	COG0800	Aldolase
LK04_RS18820	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS18825	COG2271	Major facilitator Superfamily
LK04_RS18830	COG0823	Involved in the tonB-independent uptake of proteins
LK04_RS18835	COG5645	(Lipo)protein
LK04_RS18845	COG0697	spore germination
LK04_RS18850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK04_RS18875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK04_RS18880	COG3977	Valine--pyruvate aminotransferase
LK04_RS18895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS18905	COG1609	Transcriptional regulator
LK04_RS18915	COG2885	chlorophyll binding
LK04_RS18920	COG2818	Glycosylase
LK04_RS18925	COG5571	outer membrane autotransporter
LK04_RS18935	COG1484	DNA-dependent DNA replication
LK04_RS18945	COG2814	Major facilitator Superfamily
LK04_RS18950	COG1609	Transcriptional regulator
LK04_RS18960	COG2814	Major facilitator Superfamily
LK04_RS18965	COG0704	Plays a role in the regulation of phosphate uptake
LK04_RS18970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK04_RS18975	COG0581	inorganic phosphate transmembrane transporter activity
LK04_RS18980	COG0573	inorganic phosphate transmembrane transporter activity
LK04_RS18985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LK04_RS18995	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK04_RS19005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LK04_RS19010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK04_RS19015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK04_RS19020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK04_RS19025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK04_RS19035	COG0356	it plays a direct role in the translocation of protons across the membrane
LK04_RS19040	COG3312	ion transport
LK04_RS19045	COG0357	Ribosomal RNA small subunit methyltransferase G
LK04_RS19055	COG0716	FMN binding
LK04_RS19060	COG1522	sequence-specific DNA binding
LK04_RS19065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LK04_RS19080	COG3158	transport of potassium into the cell
LK04_RS19095	COG3111	PFAM Bacterial OB fold (BOF) protein
LK04_RS19100	COG1869	D-ribose catabolic process
LK04_RS19105	COG1129	ABC transporter
LK04_RS19110	COG1172	Belongs to the binding-protein-dependent transport system permease family
LK04_RS19115	COG1879	ABC-type sugar transport system periplasmic component
LK04_RS19120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LK04_RS19125	COG1609	Transcriptional regulator
LK04_RS19130	COG0477	Major facilitator Superfamily
LK04_RS19155	COG1763	Mo-molybdopterin cofactor biosynthetic process
LK04_RS19160	COG0746	molybdenum cofactor guanylyltransferase activity
LK04_RS19165	COG3084	Protein conserved in bacteria
LK04_RS19170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LK04_RS19180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK04_RS19180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK04_RS19190	COG3078	GTPase activator activity
LK04_RS19205	COG3852	Histidine kinase
LK04_RS19220	COG1011	Hydrolase
LK04_RS19230	COG1490	D-aminoacyl-tRNA deacylase activity
LK04_RS19235	COG0456	acetyltransferase
LK04_RS19240	COG2982	Protein involved in outer membrane biogenesis
LK04_RS19245	COG2233	PERMEase
LK04_RS19250	COG0604	alcohol dehydrogenase
LK04_RS19260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LK04_RS19265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK04_RS19270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK04_RS19275	COG1758	RNA polymerase activity
LK04_RS19280	COG0194	GDP metabolic process
LK04_RS19290	COG2244	polysaccharide biosynthetic process
LK04_RS19315	COG1560	Kdo2-lipid A biosynthetic process
LK04_RS19320	COG4580	involved in the transport of maltose and maltodextrins
LK04_RS19325	COG0366	Alpha amylase catalytic
LK04_RS19330	COG1263	PTS System
LK04_RS19330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK04_RS19335	COG1609	Transcriptional regulator
LK04_RS19340	COG1561	YicC-like family, N-terminal region
LK04_RS19350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LK04_RS19355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LK04_RS19365	COG1309	transcriptional regulator
LK04_RS19375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LK04_RS19380	COG2003	Belongs to the UPF0758 family
LK04_RS19385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK04_RS19395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK04_RS19400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK04_RS19410	COG1519	Transferase
LK04_RS19420	COG0859	PFAM glycosyl transferase family 9
LK04_RS19425	COG1216	Glycosyl transferase, family 2
LK04_RS19440	COG0438	transferase activity, transferring glycosyl groups
LK04_RS19450	COG0156	8-amino-7-oxononanoate synthase activity
LK04_RS19455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK04_RS19460	COG0859	PFAM glycosyl transferase family 9
LK04_RS19465	COG0859	PFAM glycosyl transferase family 9
LK04_RS19475	COG0859	PFAM glycosyl transferase family 9
LK04_RS19480	COG2861	carbohydrate metabolic process
LK04_RS19485	COG4942	peptidase
LK04_RS19490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK04_RS19495	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK04_RS19505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK04_RS19510	COG1045	serine acetyltransferase
LK04_RS19515	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LK04_RS19520	COG2205	protein histidine kinase activity
LK04_RS19525	COG0745	RESPONSE REGULATOR receiver
LK04_RS19530	COG3678	ATP-independent chaperone mediated protein folding
LK04_RS19540	COG0205	6-phosphofructokinase activity
LK04_RS19545	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LK04_RS19555	COG0149	triose-phosphate isomerase activity
LK04_RS19570	COG2814	Major facilitator Superfamily
LK04_RS19575	COG1494	fructose-1,6-bisphosphatase
LK04_RS19580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LK04_RS19585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK04_RS19590	COG3074	FtsZ-dependent cytokinesis
LK04_RS19595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LK04_RS19605	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LK04_RS19610	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LK04_RS19615	COG1609	Transcriptional regulator
LK04_RS19620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LK04_RS19625	COG0254	rRNA binding
LK04_RS19630	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LK04_RS19635	COG0626	cystathionine gamma-synthase activity
LK04_RS19640	COG0527	aspartate kinase activity
LK04_RS19640	COG0460	homoserine dehydrogenase
LK04_RS19650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LK04_RS19655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK04_RS19665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK04_RS19670	COG0137	argininosuccinate synthase activity
LK04_RS19675	COG0165	Argininosuccinate lyase
LK04_RS19685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK04_RS19705	COG4206	TonB-dependent receptor
LK04_RS19755	COG0583	DNA-binding transcription factor activity
LK04_RS19760	COG3085	chromosome segregation
LK04_RS19765	COG0606	chelatase, subunit chli
LK04_RS19775	COG3978	acetolactate synthase activity
LK04_RS19780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK04_RS19785	COG0129	dihydroxy-acid dehydratase activity
LK04_RS19805	COG0477	Major facilitator Superfamily
LK04_RS19810	COG1295	ribonuclease BN
LK04_RS19815	COG0583	DNA-binding transcription factor activity
LK04_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
LK04_RS19830	COG0625	glutathione transferase activity
LK04_RS19835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK04_RS19850	COG4680	protein conserved in bacteria
LK04_RS19865	COG1971	Probably functions as a manganese efflux pump
LK04_RS19875	COG4948	Mandelate Racemase Muconate Lactonizing
LK04_RS19880	COG4172	Belongs to the ABC transporter superfamily
LK04_RS19890	COG0601	transmembrane transport
LK04_RS19895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK04_RS19915	COG0551	DNA topoisomerase type I activity
LK04_RS19940	COG2801	Transposase and inactivated derivatives
LK04_RS19960	COG5487	UPF0391 membrane protein
LK04_RS19995	COG1645	bacterial-type flagellum-dependent swarming motility
LK04_RS20130	COG3729	General stress protein
LK04_RS20135	COG3130	regulation of translation
LK04_RS20180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK04_RS20245	COG2860	membrane