locus-tag	class	description
HHO38_RS00010	COG1792	Involved in formation and maintenance of cell shape
HHO38_RS00025	COG0772	Belongs to the SEDS family
HHO38_RS00035	COG1774	PSP1 C-terminal conserved region
HHO38_RS00040	COG0156	8-amino-7-oxononanoate synthase activity
HHO38_RS00045	COG1597	lipid kinase activity
HHO38_RS00050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HHO38_RS00055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHO38_RS00065	COG0673	inositol 2-dehydrogenase activity
HHO38_RS00075	COG0673	inositol 2-dehydrogenase activity
HHO38_RS00100	COG1882	Formate acetyltransferase
HHO38_RS00105	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HHO38_RS00110	COG1940	carbohydrate kinase activity
HHO38_RS00135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHO38_RS00160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHO38_RS00165	COG0799	negative regulation of ribosome biogenesis
HHO38_RS00185	COG4152	abc transporter atp-binding protein
HHO38_RS00190	COG0358	DNA primase activity
HHO38_RS00240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHO38_RS00245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HHO38_RS00260	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS00265	COG1215	transferase activity, transferring glycosyl groups
HHO38_RS00280	COG3475	LICD family
HHO38_RS00290	COG1086	Polysaccharide biosynthesis protein
HHO38_RS00310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS00325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHO38_RS00340	COG1088	dTDP-glucose 4,6-dehydratase activity
HHO38_RS00365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHO38_RS00365	COG0519	Catalyzes the synthesis of GMP from XMP
HHO38_RS00370	COG0519	Catalyzes the synthesis of GMP from XMP
HHO38_RS00385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HHO38_RS00400	COG0501	Belongs to the peptidase M48B family
HHO38_RS00410	COG0583	DNA-binding transcription factor activity
HHO38_RS00415	COG2855	membrane
HHO38_RS00420	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HHO38_RS00425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HHO38_RS00430	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HHO38_RS00435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHO38_RS00440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HHO38_RS00445	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HHO38_RS00450	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HHO38_RS00465	COG0409	Hydrogenase expression formation protein
HHO38_RS00480	COG0375	protein maturation
HHO38_RS00485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HHO38_RS00515	COG0674	pyruvate-flavodoxin oxidoreductase activity
HHO38_RS00515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HHO38_RS00515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HHO38_RS00515	COG1013	pyruvate-flavodoxin oxidoreductase activity
HHO38_RS00540	COG0737	Belongs to the 5'-nucleotidase family
HHO38_RS00575	COG0657	acetylesterase activity
HHO38_RS00575	COG2755	lipolytic protein G-D-S-L family
HHO38_RS00600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHO38_RS00615	COG1312	Catalyzes the dehydration of D-mannonate
HHO38_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS00625	COG1609	Transcriptional regulator
HHO38_RS00635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS00650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHO38_RS00660	COG0039	L-malate dehydrogenase activity
HHO38_RS00665	COG1629	transport
HHO38_RS00665	COG4206	TonB-dependent receptor
HHO38_RS00670	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS00685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHO38_RS00700	COG0667	Aldo Keto reductase
HHO38_RS00705	COG0348	domain, Protein
HHO38_RS00710	COG1674	ftsk spoiiie
HHO38_RS00720	COG0492	ferredoxin-NADP+ reductase activity
HHO38_RS00735	COG1649	PFAM Uncharacterised BCR, COG1649
HHO38_RS00745	COG4771	TonB-dependent receptor
HHO38_RS00785	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHO38_RS00790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HHO38_RS00805	COG0561	phosphatase activity
HHO38_RS00810	COG4771	TonB-dependent receptor
HHO38_RS00820	COG4974	Belongs to the 'phage' integrase family
HHO38_RS00855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHO38_RS00865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHO38_RS00870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS00880	COG4641	Protein conserved in bacteria
HHO38_RS00880	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS00910	COG1091	dTDP-4-dehydrorhamnose reductase activity
HHO38_RS00955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HHO38_RS00960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HHO38_RS00965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HHO38_RS00980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHO38_RS00995	COG3118	belongs to the thioredoxin family
HHO38_RS01000	COG1288	antiporter activity
HHO38_RS01010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HHO38_RS01015	COG0577	efflux transmembrane transporter activity
HHO38_RS01015	COG1136	(ABC) transporter
HHO38_RS01025	COG2204	response regulator
HHO38_RS01030	COG3852	Histidine kinase
HHO38_RS01035	COG0534	Mate efflux family protein
HHO38_RS01045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HHO38_RS01065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHO38_RS01065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHO38_RS01070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHO38_RS01075	COG0357	Ribosomal RNA small subunit methyltransferase G
HHO38_RS01110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHO38_RS01115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHO38_RS01120	COG4942	peptidase
HHO38_RS01125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HHO38_RS01140	COG0686	Belongs to the AlaDH PNT family
HHO38_RS01145	COG0653	protein targeting
HHO38_RS01150	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
HHO38_RS01175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHO38_RS01185	COG4771	TonB-dependent receptor
HHO38_RS01195	COG1119	ATPase activity
HHO38_RS01205	COG4771	TonB-dependent receptor
HHO38_RS01210	COG4771	TonB-dependent receptor
HHO38_RS01235	COG4206	TonB-dependent receptor
HHO38_RS01235	COG1629	transport
HHO38_RS01250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHO38_RS01255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HHO38_RS01260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHO38_RS01270	COG1011	Hydrolase
HHO38_RS01280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHO38_RS01285	COG4657	Part of a membrane complex involved in electron transport
HHO38_RS01290	COG4660	Part of a membrane complex involved in electron transport
HHO38_RS01295	COG4659	FMN binding
HHO38_RS01300	COG4658	electron transport chain
HHO38_RS01305	COG4656	Part of a membrane complex involved in electron transport
HHO38_RS01310	COG1245	4Fe-4S binding domain
HHO38_RS01310	COG2878	Part of a membrane complex involved in electron transport
HHO38_RS01325	COG0504	CTP synthase activity
HHO38_RS01330	COG0706	membrane insertase activity
HHO38_RS01340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHO38_RS01345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HHO38_RS01345	COG4651	solute:proton antiporter activity
HHO38_RS01355	COG1030	water channel activity
HHO38_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
HHO38_RS01370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHO38_RS01375	COG0321	lipoyl(octanoyl) transferase activity
HHO38_RS01390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HHO38_RS01395	COG1546	Belongs to the CinA family
HHO38_RS01395	COG1058	Belongs to the CinA family
HHO38_RS01405	COG4948	Mandelate Racemase Muconate Lactonizing
HHO38_RS01410	COG3275	phosphorelay sensor kinase activity
HHO38_RS01420	COG0791	NLP P60 protein
HHO38_RS01425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHO38_RS01440	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHO38_RS01445	COG1846	Transcriptional regulator
HHO38_RS01450	COG0167	dihydroorotate dehydrogenase activity
HHO38_RS01465	COG4974	Belongs to the 'phage' integrase family
HHO38_RS01480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS01550	COG1216	Glycosyl transferase, family 2
HHO38_RS01550	COG1442	glycosyl transferase family 8
HHO38_RS01555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS01560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HHO38_RS01570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHO38_RS01575	COG1216	Glycosyl transferase, family 2
HHO38_RS01575	COG1442	glycosyl transferase family 8
HHO38_RS01580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHO38_RS01595	COG0105	UTP biosynthetic process
HHO38_RS01635	COG0667	Aldo Keto reductase
HHO38_RS01655	COG3590	peptidase
HHO38_RS01675	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS01680	COG4206	TonB-dependent receptor
HHO38_RS01680	COG1629	transport
HHO38_RS01710	COG1575	Belongs to the MenA family. Type 1 subfamily
HHO38_RS01720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HHO38_RS01725	COG0047	phosphoribosylformylglycinamidine synthase activity
HHO38_RS01735	COG0848	biopolymer transport protein
HHO38_RS01740	COG0811	peptide transport
HHO38_RS01745	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HHO38_RS01755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HHO38_RS01760	COG1216	Glycosyl transferase, family 2
HHO38_RS01785	COG2223	nitrite transmembrane transporter activity
HHO38_RS01795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS01820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHO38_RS01825	COG0488	(ABC) transporter
HHO38_RS01885	COG2161	toxin-antitoxin pair type II binding
HHO38_RS01910	COG1595	DNA-templated transcription, initiation
HHO38_RS01975	COG0582	viral genome integration into host DNA
HHO38_RS01995	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HHO38_RS02005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHO38_RS02040	COG4771	TonB-dependent receptor
HHO38_RS02045	COG0702	epimerase
HHO38_RS02125	COG2233	PERMEase
HHO38_RS02130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHO38_RS02155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHO38_RS02185	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HHO38_RS02190	COG0826	peptidase U32
HHO38_RS02215	COG2205	protein histidine kinase activity
HHO38_RS02215	COG3292	Two component regulator propeller
HHO38_RS02215	COG0745	RESPONSE REGULATOR receiver
HHO38_RS02230	COG1506	peptidase
HHO38_RS02230	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS02235	COG1830	Aldolase
HHO38_RS02240	COG1592	Rubrerythrin
HHO38_RS02240	COG1773	rubredoxin
HHO38_RS02250	COG0519	Catalyzes the synthesis of GMP from XMP
HHO38_RS02260	COG0481	GTPase activity
HHO38_RS02265	COG2996	Protein conserved in bacteria
HHO38_RS02280	COG3475	LICD family
HHO38_RS02285	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS02290	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS02300	COG2244	polysaccharide biosynthetic process
HHO38_RS02330	COG1918	ferrous iron import across plasma membrane
HHO38_RS02330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HHO38_RS02345	COG2264	protein methyltransferase activity
HHO38_RS02360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HHO38_RS02375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HHO38_RS02380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHO38_RS02385	COG1748	Saccharopine dehydrogenase
HHO38_RS02405	COG0842	Transport permease protein
HHO38_RS02405	COG1716	ATPase activity
HHO38_RS02405	COG1131	(ABC) transporter
HHO38_RS02420	COG4771	TonB-dependent receptor
HHO38_RS02430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HHO38_RS02435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHO38_RS02460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HHO38_RS02470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHO38_RS02475	COG1678	Uncharacterized ACR, COG1678
HHO38_RS02495	COG0110	maltose O-acetyltransferase activity
HHO38_RS02555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HHO38_RS02560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HHO38_RS02570	COG0037	tRNA processing
HHO38_RS02580	COG0513	Belongs to the DEAD box helicase family
HHO38_RS02590	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HHO38_RS02640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHO38_RS02645	COG1914	H( )-stimulated, divalent metal cation uptake system
HHO38_RS02650	COG3852	Histidine kinase
HHO38_RS02660	COG2814	Major facilitator Superfamily
HHO38_RS02665	COG0534	Mate efflux family protein
HHO38_RS02690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HHO38_RS02695	COG0436	Aminotransferase
HHO38_RS02705	COG1609	Transcriptional regulator
HHO38_RS02705	COG2207	Transcriptional regulator
HHO38_RS02720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHO38_RS02725	COG2183	response to ionizing radiation
HHO38_RS02735	COG3842	ATPase activity
HHO38_RS02755	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HHO38_RS02760	COG0784	Response regulator, receiver
HHO38_RS02760	COG5002	protein histidine kinase activity
HHO38_RS02760	COG2205	protein histidine kinase activity
HHO38_RS02765	COG0693	protein deglycase activity
HHO38_RS02775	COG0673	inositol 2-dehydrogenase activity
HHO38_RS02780	COG1492	cobalamin metabolic process
HHO38_RS02785	COG4974	Belongs to the 'phage' integrase family
HHO38_RS02805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS02815	COG2244	polysaccharide biosynthetic process
HHO38_RS02835	COG3475	LICD family
HHO38_RS02840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HHO38_RS02840	COG0463	Glycosyl transferase, family 2
HHO38_RS02870	COG1760	l-serine dehydratase
HHO38_RS02880	COG1309	transcriptional regulator
HHO38_RS02890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS02895	COG1131	(ABC) transporter
HHO38_RS02900	COG1131	(ABC) transporter
HHO38_RS02905	COG0842	Transport permease protein
HHO38_RS02915	COG2610	gluconate transmembrane transporter activity
HHO38_RS02955	COG1070	Carbohydrate kinase
HHO38_RS02960	COG4806	L-rhamnose isomerase
HHO38_RS02970	COG0235	Class ii aldolase
HHO38_RS02980	COG3250	beta-galactosidase activity
HHO38_RS03000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HHO38_RS03040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHO38_RS03065	COG0583	DNA-binding transcription factor activity
HHO38_RS03070	COG0463	Glycosyl transferase, family 2
HHO38_RS03075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHO38_RS03080	COG0602	queuosine metabolic process
HHO38_RS03095	COG1215	transferase activity, transferring glycosyl groups
HHO38_RS03100	COG0463	Glycosyl transferase, family 2
HHO38_RS03100	COG1216	Glycosyl transferase, family 2
HHO38_RS03110	COG1216	Glycosyl transferase, family 2
HHO38_RS03130	COG1388	LysM domain
HHO38_RS03130	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHO38_RS03150	COG0358	DNA primase activity
HHO38_RS03155	COG0305	Participates in initiation and elongation during chromosome replication
HHO38_RS03175	COG1216	Glycosyl transferase, family 2
HHO38_RS03205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS03220	COG3153	acetyltransferase
HHO38_RS03220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHO38_RS03225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHO38_RS03230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHO38_RS03240	COG0488	(ABC) transporter
HHO38_RS03270	COG1309	transcriptional regulator
HHO38_RS03335	COG4974	Belongs to the 'phage' integrase family
HHO38_RS03345	COG0667	Aldo Keto reductase
HHO38_RS03350	COG2249	NAD(P)H dehydrogenase (quinone) activity
HHO38_RS03355	COG0583	DNA-binding transcription factor activity
HHO38_RS03410	COG0037	tRNA processing
HHO38_RS03490	COG0358	DNA primase activity
HHO38_RS03575	COG0705	Rhomboid family
HHO38_RS03750	COG1309	transcriptional regulator
HHO38_RS03760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHO38_RS03760	COG0551	DNA topoisomerase type I activity
HHO38_RS03785	COG0582	viral genome integration into host DNA
HHO38_RS03830	COG4974	Belongs to the 'phage' integrase family
HHO38_RS03860	COG1733	regulation of RNA biosynthetic process
HHO38_RS03870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHO38_RS03875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHO38_RS03925	COG0598	Magnesium transport protein CorA
HHO38_RS03930	COG1193	negative regulation of DNA recombination
HHO38_RS03940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HHO38_RS03945	COG0484	heat shock protein binding
HHO38_RS03950	COG2096	Adenosyltransferase
HHO38_RS03955	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HHO38_RS03965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS03970	COG0336	Belongs to the RNA methyltransferase TrmD family
HHO38_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHO38_RS03975	COG0072	phenylalanine-tRNA ligase activity
HHO38_RS03980	COG0217	transcriptional regulatory protein
HHO38_RS04000	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS04000	COG1506	peptidase
HHO38_RS04000	COG4946	Tricorn protease homolog
HHO38_RS04010	COG3022	response to hydroperoxide
HHO38_RS04025	COG0542	response to heat
HHO38_RS04030	COG2205	protein histidine kinase activity
HHO38_RS04030	COG2202	Pas domain
HHO38_RS04040	COG1360	Flagellar Motor Protein
HHO38_RS04100	COG1472	Belongs to the glycosyl hydrolase 3 family
HHO38_RS04125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HHO38_RS04140	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HHO38_RS04145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHO38_RS04150	COG4690	dipeptidase activity
HHO38_RS04160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHO38_RS04170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HHO38_RS04195	COG3119	arylsulfatase activity
HHO38_RS04200	COG0667	Aldo Keto reductase
HHO38_RS04210	COG1956	GAF domain-containing protein
HHO38_RS04215	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHO38_RS04220	COG1518	maintenance of DNA repeat elements
HHO38_RS04250	COG0534	Mate efflux family protein
HHO38_RS04255	COG2957	Belongs to the agmatine deiminase family
HHO38_RS04270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHO38_RS04325	COG0514	ATP-dependent DNA helicase (RecQ)
HHO38_RS04330	COG0513	Belongs to the DEAD box helicase family
HHO38_RS04345	COG1629	transport
HHO38_RS04355	COG3119	arylsulfatase activity
HHO38_RS04360	COG0673	inositol 2-dehydrogenase activity
HHO38_RS04365	COG0673	inositol 2-dehydrogenase activity
HHO38_RS04375	COG3437	response regulator, receiver
HHO38_RS04375	COG2205	protein histidine kinase activity
HHO38_RS04375	COG4999	Histidine kinase
HHO38_RS04375	COG3850	Histidine kinase
HHO38_RS04380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHO38_RS04395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HHO38_RS04400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHO38_RS04400	COG0321	lipoyl(octanoyl) transferase activity
HHO38_RS04420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHO38_RS04425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHO38_RS04445	COG4948	Mandelate Racemase Muconate Lactonizing
HHO38_RS04455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HHO38_RS04460	COG1169	isochorismate synthase
HHO38_RS04470	COG0561	phosphatase activity
HHO38_RS04475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HHO38_RS04485	COG3681	Belongs to the UPF0597 family
HHO38_RS04495	COG0402	S-adenosylhomocysteine deaminase activity
HHO38_RS04510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHO38_RS04515	COG1805	sodium ion transport
HHO38_RS04520	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHO38_RS04530	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HHO38_RS04570	COG0543	2 iron, 2 sulfur cluster binding
HHO38_RS04575	COG0167	dihydroorotate dehydrogenase activity
HHO38_RS04580	COG0708	Exodeoxyribonuclease III
HHO38_RS04620	COG1725	Transcriptional regulator
HHO38_RS04630	COG1131	(ABC) transporter
HHO38_RS04645	COG0006	proline dipeptidase activity
HHO38_RS04670	COG0613	PHP domain protein
HHO38_RS04690	COG0542	response to heat
HHO38_RS04710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HHO38_RS04715	COG0402	S-adenosylhomocysteine deaminase activity
HHO38_RS04720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHO38_RS04740	COG0531	amino acid
HHO38_RS04755	COG0372	Belongs to the citrate synthase family
HHO38_RS04760	COG0538	isocitrate dehydrogenase activity
HHO38_RS04775	COG2985	domain, Protein
HHO38_RS04780	COG4822	anaerobic cobalamin biosynthetic process
HHO38_RS04810	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HHO38_RS04820	COG0351	phosphomethylpyrimidine kinase
HHO38_RS04830	COG0352	thiamine-phosphate diphosphorylase activity
HHO38_RS04835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HHO38_RS04845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHO38_RS04850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHO38_RS04855	COG2198	Histidine kinase
HHO38_RS04855	COG0784	Response regulator, receiver
HHO38_RS04855	COG5002	protein histidine kinase activity
HHO38_RS04860	COG0745	RESPONSE REGULATOR receiver
HHO38_RS04880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS04885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHO38_RS04885	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HHO38_RS04890	COG1858	cytochrome C peroxidase
HHO38_RS04895	COG1704	LemA family
HHO38_RS04925	COG1045	serine acetyltransferase
HHO38_RS04940	COG0515	serine threonine protein kinase
HHO38_RS04970	COG5002	protein histidine kinase activity
HHO38_RS04970	COG2205	protein histidine kinase activity
HHO38_RS04970	COG0784	Response regulator, receiver
HHO38_RS04975	COG0574	Belongs to the PEP-utilizing enzyme family
HHO38_RS04975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHO38_RS04990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHO38_RS04995	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HHO38_RS05020	COG3655	Transcriptional regulator
HHO38_RS05040	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHO38_RS05040	COG1902	pentaerythritol trinitrate reductase activity
HHO38_RS05135	COG1120	ATPase activity
HHO38_RS05160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HHO38_RS05165	COG0442	prolyl-tRNA aminoacylation
HHO38_RS05175	COG0028	Belongs to the TPP enzyme family
HHO38_RS05195	COG3250	beta-galactosidase activity
HHO38_RS05200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HHO38_RS05215	COG2207	Transcriptional regulator
HHO38_RS05215	COG0662	Cupin 2, conserved barrel domain protein
HHO38_RS05220	COG2207	Transcriptional regulator
HHO38_RS05220	COG4753	response regulator
HHO38_RS05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS05265	COG0131	Imidazoleglycerol-phosphate dehydratase
HHO38_RS05270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHO38_RS05275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHO38_RS05280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHO38_RS05285	COG0582	viral genome integration into host DNA
HHO38_RS05315	COG1401	restriction endodeoxyribonuclease activity
HHO38_RS05345	COG0612	Peptidase, M16
HHO38_RS05350	COG0668	transmembrane transport
HHO38_RS05355	COG0668	transmembrane transport
HHO38_RS05390	COG0671	phosphoesterase, PA-phosphatase related
HHO38_RS05410	COG2304	oxidoreductase activity
HHO38_RS05415	COG2304	oxidoreductase activity
HHO38_RS05430	COG0714	Associated with various cellular activities
HHO38_RS05440	COG0776	regulation of translation
HHO38_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHO38_RS05450	COG0552	protein localization to endoplasmic reticulum
HHO38_RS05490	COG0724	RNA recognition motif
HHO38_RS05495	COG2373	Large extracellular alpha-helical protein
HHO38_RS05495	COG2373	Large extracellular alpha-helical protein
HHO38_RS05515	COG0366	Alpha amylase catalytic
HHO38_RS05530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HHO38_RS05540	COG1739	Uncharacterized protein family UPF0029
HHO38_RS05550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHO38_RS05560	COG0531	amino acid
HHO38_RS05575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HHO38_RS05580	COG0641	radical SAM
HHO38_RS05585	COG0312	modulator of DNA gyrase
HHO38_RS05595	COG1272	protein, Hemolysin III
HHO38_RS05605	COG2217	Heavy metal translocating P-type atpase
HHO38_RS05625	COG1785	Belongs to the alkaline phosphatase family
HHO38_RS05630	COG0540	Belongs to the ATCase OTCase family
HHO38_RS05635	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HHO38_RS05650	COG1253	flavin adenine dinucleotide binding
HHO38_RS05655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HHO38_RS05660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHO38_RS05665	COG0463	Glycosyl transferase, family 2
HHO38_RS05700	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS05805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHO38_RS05805	COG0551	DNA topoisomerase type I activity
HHO38_RS05820	COG0582	viral genome integration into host DNA
HHO38_RS05840	COG3344	reverse transcriptase
HHO38_RS05850	COG1309	transcriptional regulator
HHO38_RS05855	COG4974	Belongs to the 'phage' integrase family
HHO38_RS05945	COG2205	protein histidine kinase activity
HHO38_RS05945	COG2198	Histidine kinase
HHO38_RS05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS05945	COG0784	Response regulator, receiver
HHO38_RS06050	COG0358	DNA primase activity
HHO38_RS06125	COG0358	DNA primase activity
HHO38_RS06150	COG4974	Belongs to the 'phage' integrase family
HHO38_RS06155	COG0582	viral genome integration into host DNA
HHO38_RS06160	COG0582	viral genome integration into host DNA
HHO38_RS06205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS06220	COG4974	Belongs to the 'phage' integrase family
HHO38_RS06240	COG1269	ATP hydrolysis coupled proton transport
HHO38_RS06255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HHO38_RS06285	COG0477	Major facilitator Superfamily
HHO38_RS06290	COG0076	glutamate decarboxylase activity
HHO38_RS06295	COG2066	Belongs to the glutaminase family
HHO38_RS06320	COG0572	uridine kinase
HHO38_RS06330	COG0671	phosphoesterase, PA-phosphatase related
HHO38_RS06335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HHO38_RS06355	COG0745	RESPONSE REGULATOR receiver
HHO38_RS06360	COG5002	protein histidine kinase activity
HHO38_RS06365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS06365	COG2205	protein histidine kinase activity
HHO38_RS06370	COG3279	Response regulator of the LytR AlgR family
HHO38_RS06375	COG3275	phosphorelay sensor kinase activity
HHO38_RS06390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHO38_RS06400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHO38_RS06420	COG0175	sulfate reduction
HHO38_RS06425	COG0529	Catalyzes the synthesis of activated sulfate
HHO38_RS06430	COG3273	potassium ion transport
HHO38_RS06430	COG0471	metal ion transport
HHO38_RS06465	COG0477	Major facilitator Superfamily
HHO38_RS06465	COG2814	Major facilitator Superfamily
HHO38_RS06470	COG2115	Belongs to the xylose isomerase family
HHO38_RS06485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHO38_RS06505	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHO38_RS06510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHO38_RS06510	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHO38_RS06515	COG0343	queuine tRNA-ribosyltransferase activity
HHO38_RS06535	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HHO38_RS06580	COG0285	dihydrofolate synthase activity
HHO38_RS06590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HHO38_RS06620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HHO38_RS06630	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS06630	COG1506	peptidase
HHO38_RS06640	COG0039	L-malate dehydrogenase activity
HHO38_RS06645	COG1032	radical SAM domain protein
HHO38_RS06650	COG0251	oxidation-reduction process
HHO38_RS06655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHO38_RS06680	COG3275	phosphorelay sensor kinase activity
HHO38_RS06685	COG3279	Response regulator of the LytR AlgR family
HHO38_RS06695	COG0497	DNA recombination
HHO38_RS06710	COG1979	alcohol dehydrogenase
HHO38_RS06715	COG2176	DNA-directed DNA polymerase activity
HHO38_RS06730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHO38_RS06735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HHO38_RS06755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHO38_RS06760	COG0022	dehydrogenase e1 component
HHO38_RS06765	COG0716	FMN binding
HHO38_RS06770	COG1846	Transcriptional regulator
HHO38_RS06820	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHO38_RS06825	COG0784	Response regulator, receiver
HHO38_RS06825	COG2205	protein histidine kinase activity
HHO38_RS06835	COG0126	phosphoglycerate kinase activity
HHO38_RS06840	COG1523	belongs to the glycosyl hydrolase 13 family
HHO38_RS06845	COG0305	Participates in initiation and elongation during chromosome replication
HHO38_RS06860	COG3537	Alpha-1,2-mannosidase
HHO38_RS06865	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHO38_RS06880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHO38_RS06885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHO38_RS06890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HHO38_RS06895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HHO38_RS06905	COG4770	biotin carboxylase activity
HHO38_RS06910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHO38_RS06915	COG0242	peptide deformylase activity
HHO38_RS06920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HHO38_RS06925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS06930	COG2885	chlorophyll binding
HHO38_RS06935	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HHO38_RS06940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS06955	COG0363	glucosamine-6-phosphate deaminase activity
HHO38_RS06960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HHO38_RS06965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HHO38_RS06970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHO38_RS06990	COG2204	response regulator
HHO38_RS06995	COG2311	Membrane
HHO38_RS07000	COG0784	Response regulator, receiver
HHO38_RS07000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS07000	COG2198	Histidine kinase
HHO38_RS07000	COG2205	protein histidine kinase activity
HHO38_RS07005	COG2194	sulfuric ester hydrolase activity
HHO38_RS07010	COG1115	amino acid carrier protein
HHO38_RS07020	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HHO38_RS07045	COG2376	Dihydroxyacetone kinase
HHO38_RS07085	COG0783	Belongs to the Dps family
HHO38_RS07095	COG0783	Belongs to the Dps family
HHO38_RS07105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHO38_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
HHO38_RS07130	COG1757	Na H antiporter
HHO38_RS07145	COG1509	lysine 2,3-aminomutase activity
HHO38_RS07155	COG4771	TonB-dependent receptor
HHO38_RS07170	COG1629	transport
HHO38_RS07170	COG4206	TonB-dependent receptor
HHO38_RS07180	COG4206	TonB-dependent receptor
HHO38_RS07180	COG1629	transport
HHO38_RS07190	COG3189	MarR family transcriptional regulator
HHO38_RS07195	COG0588	phosphoglycerate mutase activity
HHO38_RS07210	COG1027	Aspartate ammonia-lyase
HHO38_RS07215	COG0133	tryptophan synthase activity
HHO38_RS07220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHO38_RS07235	COG0134	indole-3-glycerol-phosphate synthase activity
HHO38_RS07240	COG0135	phosphoribosylanthranilate isomerase activity
HHO38_RS07245	COG0159	tryptophan synthase activity
HHO38_RS07250	COG1979	alcohol dehydrogenase
HHO38_RS07260	COG1139	Iron-sulfur cluster binding protein
HHO38_RS07265	COG0247	lactate metabolic process
HHO38_RS07275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHO38_RS07280	COG0505	Belongs to the CarA family
HHO38_RS07295	COG1215	transferase activity, transferring glycosyl groups
HHO38_RS07305	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS07385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS07405	COG0339	signal peptide processing
HHO38_RS07410	COG0339	signal peptide processing
HHO38_RS07450	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HHO38_RS07465	COG1475	DNA binding
HHO38_RS07470	COG3969	phosphoadenosine phosphosulfate
HHO38_RS07505	COG3537	Alpha-1,2-mannosidase
HHO38_RS07510	COG3537	Alpha-1,2-mannosidase
HHO38_RS07520	COG4771	TonB-dependent receptor
HHO38_RS07550	COG4771	TonB-dependent receptor
HHO38_RS07565	COG3537	Alpha-1,2-mannosidase
HHO38_RS07615	COG1136	(ABC) transporter
HHO38_RS07645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHO38_RS07650	COG1011	Hydrolase
HHO38_RS07655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HHO38_RS07660	COG1177	transmembrane transport
HHO38_RS07665	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHO38_RS07670	COG3842	ATPase activity
HHO38_RS07675	COG3250	beta-galactosidase activity
HHO38_RS07685	COG0463	Glycosyl transferase, family 2
HHO38_RS07690	COG2246	polysaccharide biosynthetic process
HHO38_RS07715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHO38_RS07720	COG0702	epimerase
HHO38_RS07725	COG1629	transport
HHO38_RS07725	COG4206	TonB-dependent receptor
HHO38_RS07735	COG1733	regulation of RNA biosynthetic process
HHO38_RS07765	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HHO38_RS07780	COG0698	ribose 5-phosphate isomerase
HHO38_RS07810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HHO38_RS07825	COG3119	arylsulfatase activity
HHO38_RS07830	COG3119	arylsulfatase activity
HHO38_RS07845	COG1629	transport
HHO38_RS07865	COG1595	DNA-templated transcription, initiation
HHO38_RS07875	COG1629	transport
HHO38_RS07910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHO38_RS07920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHO38_RS07925	COG2333	competence protein COMEC
HHO38_RS07925	COG0658	competence protein
HHO38_RS07930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHO38_RS07940	COG1595	DNA-templated transcription, initiation
HHO38_RS07955	COG0589	response to stress
HHO38_RS07955	COG0475	glutathione-regulated potassium exporter activity
HHO38_RS07980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHO38_RS07985	COG0252	asparaginase activity
HHO38_RS08000	COG0488	(ABC) transporter
HHO38_RS08010	COG0228	four-way junction DNA binding
HHO38_RS08105	COG2818	Glycosylase
HHO38_RS08110	COG1482	cell wall glycoprotein biosynthetic process
HHO38_RS08115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHO38_RS08120	COG0475	glutathione-regulated potassium exporter activity
HHO38_RS08125	COG0778	Nitroreductase
HHO38_RS08135	COG0420	3'-5' exonuclease activity
HHO38_RS08155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHO38_RS08180	COG0545	Peptidyl-prolyl cis-trans isomerase
HHO38_RS08195	COG2832	Protein of unknown function (DUF454)
HHO38_RS08200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHO38_RS08205	COG0038	chloride channel
HHO38_RS08210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS08220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHO38_RS08220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHO38_RS08225	COG0514	ATP-dependent DNA helicase (RecQ)
HHO38_RS08235	COG1940	carbohydrate kinase activity
HHO38_RS08240	COG2985	domain, Protein
HHO38_RS08240	COG0569	domain protein
HHO38_RS08260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HHO38_RS08265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HHO38_RS08280	COG3537	Alpha-1,2-mannosidase
HHO38_RS08290	COG0805	protein transport
HHO38_RS08295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHO38_RS08300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHO38_RS08305	COG0657	acetylesterase activity
HHO38_RS08305	COG2755	lipolytic protein G-D-S-L family
HHO38_RS08325	COG4206	TonB-dependent receptor
HHO38_RS08325	COG1629	transport
HHO38_RS08335	COG4206	TonB-dependent receptor
HHO38_RS08335	COG1629	transport
HHO38_RS08340	COG2234	aminopeptidase activity
HHO38_RS08350	COG0288	reversible hydration of carbon dioxide
HHO38_RS08360	COG0667	Aldo Keto reductase
HHO38_RS08380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHO38_RS08385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHO38_RS08395	COG0534	Mate efflux family protein
HHO38_RS08420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHO38_RS08470	COG3119	arylsulfatase activity
HHO38_RS08480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHO38_RS08485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHO38_RS08495	COG1295	ribonuclease BN
HHO38_RS08500	COG0534	Mate efflux family protein
HHO38_RS08515	COG0484	heat shock protein binding
HHO38_RS08585	COG1309	transcriptional regulator
HHO38_RS08595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS08610	COG1902	pentaerythritol trinitrate reductase activity
HHO38_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS08620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHO38_RS08625	COG0193	aminoacyl-tRNA hydrolase activity
HHO38_RS08630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHO38_RS08655	COG0067	glutamate synthase
HHO38_RS08655	COG0070	glutamate synthase
HHO38_RS08655	COG0069	glutamate synthase activity
HHO38_RS08665	COG0367	asparagine synthase
HHO38_RS08675	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHO38_RS08680	COG0436	Aminotransferase
HHO38_RS08700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HHO38_RS08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHO38_RS08720	COG0673	inositol 2-dehydrogenase activity
HHO38_RS08730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HHO38_RS08735	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHO38_RS08740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HHO38_RS08745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHO38_RS08750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HHO38_RS08785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHO38_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS08800	COG3475	LICD family
HHO38_RS08805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS08815	COG1216	Glycosyl transferase, family 2
HHO38_RS08830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHO38_RS08855	COG4974	Belongs to the 'phage' integrase family
HHO38_RS08895	COG2264	protein methyltransferase activity
HHO38_RS08920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HHO38_RS08925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HHO38_RS08945	COG0556	nucleotide-excision repair
HHO38_RS08970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS08980	COG3142	Participates in the control of copper homeostasis
HHO38_RS08990	COG0527	aspartate kinase activity
HHO38_RS08990	COG0460	homoserine dehydrogenase
HHO38_RS08995	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HHO38_RS09000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHO38_RS09015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHO38_RS09045	COG0702	epimerase
HHO38_RS09050	COG4771	TonB-dependent receptor
HHO38_RS09065	COG0363	glucosamine-6-phosphate deaminase activity
HHO38_RS09080	COG0488	(ABC) transporter
HHO38_RS09085	COG1073	alpha beta
HHO38_RS09095	COG4771	TonB-dependent receptor
HHO38_RS09105	COG3250	beta-galactosidase activity
HHO38_RS09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHO38_RS09160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HHO38_RS09165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHO38_RS09170	COG2217	Heavy metal translocating P-type atpase
HHO38_RS09185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HHO38_RS09190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHO38_RS09195	COG0297	glycogen (starch) synthase activity
HHO38_RS09210	COG0297	glycogen (starch) synthase activity
HHO38_RS09220	COG0339	signal peptide processing
HHO38_RS09230	COG0793	Belongs to the peptidase S41A family
HHO38_RS09235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHO38_RS09245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HHO38_RS09255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHO38_RS09315	COG0300	oxidoreductase activity
HHO38_RS09325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HHO38_RS09335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHO38_RS09340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHO38_RS09365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HHO38_RS09385	COG0463	Glycosyl transferase, family 2
HHO38_RS09395	COG1971	Probably functions as a manganese efflux pump
HHO38_RS09400	COG0129	dihydroxy-acid dehydratase activity
HHO38_RS09405	COG1477	protein flavinylation
HHO38_RS09415	COG0424	maF-like protein
HHO38_RS09430	COG0778	Nitroreductase
HHO38_RS09440	COG0346	lactoylglutathione lyase activity
HHO38_RS09445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHO38_RS09455	COG0511	ligase activity, forming carbon-carbon bonds
HHO38_RS09460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHO38_RS09470	COG1214	PFAM Peptidase M22, glycoprotease
HHO38_RS09475	COG1561	YicC-like family, N-terminal region
HHO38_RS09480	COG0194	GDP metabolic process
HHO38_RS09490	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HHO38_RS09500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HHO38_RS09510	COG0166	Belongs to the GPI family
HHO38_RS09545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS09625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS09640	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHO38_RS09650	COG0673	inositol 2-dehydrogenase activity
HHO38_RS09670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHO38_RS09680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HHO38_RS09685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS09690	COG1442	glycosyl transferase family 8
HHO38_RS09690	COG1216	Glycosyl transferase, family 2
HHO38_RS09695	COG2244	polysaccharide biosynthetic process
HHO38_RS09740	COG4974	Belongs to the 'phage' integrase family
HHO38_RS09745	COG3040	lipid binding
HHO38_RS09750	COG1970	mechanosensitive ion channel activity
HHO38_RS09765	COG5002	protein histidine kinase activity
HHO38_RS09770	COG2204	response regulator
HHO38_RS09785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHO38_RS09795	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HHO38_RS09800	COG3005	denitrification pathway
HHO38_RS09805	COG1360	Flagellar Motor Protein
HHO38_RS09820	COG0738	Major facilitator superfamily
HHO38_RS09825	COG3254	rhamnose metabolic process
HHO38_RS09830	COG1051	belongs to the nudix hydrolase family
HHO38_RS09835	COG0071	Belongs to the small heat shock protein (HSP20) family
HHO38_RS09850	COG2113	Glycine betaine
HHO38_RS09855	COG4176	ABC-type proline glycine betaine transport system permease component
HHO38_RS09865	COG2205	protein histidine kinase activity
HHO38_RS09870	COG0450	alkyl hydroperoxide reductase
HHO38_RS09885	COG1741	Belongs to the pirin family
HHO38_RS09890	COG0516	GMP reductase activity
HHO38_RS09890	COG0517	IMP dehydrogenase activity
HHO38_RS09900	COG0662	Cupin 2, conserved barrel domain protein
HHO38_RS09900	COG2207	Transcriptional regulator
HHO38_RS09950	COG4974	Belongs to the 'phage' integrase family
HHO38_RS09955	COG0582	viral genome integration into host DNA
HHO38_RS09960	COG0582	viral genome integration into host DNA
HHO38_RS09985	COG0358	DNA primase activity
HHO38_RS10065	COG0358	DNA primase activity
HHO38_RS10165	COG2198	Histidine kinase
HHO38_RS10165	COG2205	protein histidine kinase activity
HHO38_RS10165	COG0784	Response regulator, receiver
HHO38_RS10165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS10180	COG3344	reverse transcriptase
HHO38_RS10200	COG0582	viral genome integration into host DNA
HHO38_RS10215	COG0551	DNA topoisomerase type I activity
HHO38_RS10215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHO38_RS10255	COG4974	Belongs to the 'phage' integrase family
HHO38_RS10260	COG4206	TonB-dependent receptor
HHO38_RS10260	COG1629	transport
HHO38_RS10290	COG1285	pathogenesis
HHO38_RS10295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HHO38_RS10305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHO38_RS10315	COG0439	Biotin carboxylase
HHO38_RS10320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHO38_RS10330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHO38_RS10340	COG1438	arginine binding
HHO38_RS10350	COG0137	argininosuccinate synthase activity
HHO38_RS10355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HHO38_RS10360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHO38_RS10390	COG4124	Belongs to the glycosyl hydrolase 26 family
HHO38_RS10395	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HHO38_RS10400	COG2211	Major facilitator Superfamily
HHO38_RS10405	COG2942	2-epimerase
HHO38_RS10425	COG1252	NADH dehydrogenase
HHO38_RS10440	COG0318	PFAM AMP-dependent synthetase and ligase
HHO38_RS10455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHO38_RS10470	COG1295	ribonuclease BN
HHO38_RS10500	COG3546	catalase activity
HHO38_RS10520	COG2095	MarC family integral membrane protein
HHO38_RS10545	COG1640	4-alpha-glucanotransferase
HHO38_RS10555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHO38_RS10565	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHO38_RS10570	COG0359	binds to the 23S rRNA
HHO38_RS10575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HHO38_RS10580	COG0360	Binds together with S18 to 16S ribosomal RNA
HHO38_RS10585	COG3119	arylsulfatase activity
HHO38_RS10590	COG3119	arylsulfatase activity
HHO38_RS10595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS10600	COG1629	transport
HHO38_RS10610	COG1595	DNA-templated transcription, initiation
HHO38_RS10620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HHO38_RS10625	COG1187	pseudouridine synthase activity
HHO38_RS10635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HHO38_RS10685	COG1215	transferase activity, transferring glycosyl groups
HHO38_RS10695	COG0616	signal peptide processing
HHO38_RS10700	COG1663	tetraacyldisaccharide 4'-kinase activity
HHO38_RS10705	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HHO38_RS10720	COG4974	Belongs to the 'phage' integrase family
HHO38_RS10775	COG0784	Response regulator, receiver
HHO38_RS10775	COG2205	protein histidine kinase activity
HHO38_RS10880	COG0582	viral genome integration into host DNA
HHO38_RS10885	COG0582	viral genome integration into host DNA
HHO38_RS10890	COG4974	Belongs to the 'phage' integrase family
HHO38_RS10925	COG0358	DNA primase activity
HHO38_RS11030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HHO38_RS11055	COG0483	inositol monophosphate 1-phosphatase activity
HHO38_RS11060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHO38_RS11290	COG1475	DNA binding
HHO38_RS11300	COG1192	Involved in chromosome partitioning
HHO38_RS11340	COG0739	heme binding
HHO38_RS11340	COG1196	nuclear chromosome segregation
HHO38_RS11340	COG0741	lytic transglycosylase activity
HHO38_RS11400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHO38_RS11435	COG1309	transcriptional regulator
HHO38_RS11560	COG2198	Histidine kinase
HHO38_RS11560	COG0784	Response regulator, receiver
HHO38_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS11560	COG2205	protein histidine kinase activity
HHO38_RS11650	COG0483	inositol monophosphate 1-phosphatase activity
HHO38_RS11665	COG2198	Histidine kinase
HHO38_RS11665	COG2205	protein histidine kinase activity
HHO38_RS11665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS11665	COG0784	Response regulator, receiver
HHO38_RS11725	COG4974	Belongs to the 'phage' integrase family
HHO38_RS11730	COG4974	Belongs to the 'phage' integrase family
HHO38_RS11765	COG3344	reverse transcriptase
HHO38_RS11775	COG0582	viral genome integration into host DNA
HHO38_RS11800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHO38_RS11800	COG0551	DNA topoisomerase type I activity
HHO38_RS11835	COG4974	Belongs to the 'phage' integrase family
HHO38_RS11845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHO38_RS11850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HHO38_RS11885	COG4771	TonB-dependent receptor
HHO38_RS11890	COG0702	epimerase
HHO38_RS11895	COG3119	arylsulfatase activity
HHO38_RS11900	COG3119	arylsulfatase activity
HHO38_RS11905	COG0584	glycerophosphoryl diester phosphodiesterase
HHO38_RS11915	COG0534	Mate efflux family protein
HHO38_RS11920	COG3387	PFAM Glycoside hydrolase 15-related
HHO38_RS11945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HHO38_RS11950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HHO38_RS11955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HHO38_RS11965	COG2205	protein histidine kinase activity
HHO38_RS11975	COG0527	aspartate kinase activity
HHO38_RS11985	COG1484	DNA-dependent DNA replication
HHO38_RS12105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHO38_RS12130	COG4771	TonB-dependent receptor
HHO38_RS12135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHO38_RS12140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHO38_RS12145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHO38_RS12155	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS12170	COG1442	glycosyl transferase family 8
HHO38_RS12170	COG1216	Glycosyl transferase, family 2
HHO38_RS12230	COG4974	Belongs to the 'phage' integrase family
HHO38_RS12245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHO38_RS12250	COG1660	Displays ATPase and GTPase activities
HHO38_RS12255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HHO38_RS12265	COG2204	response regulator
HHO38_RS12275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HHO38_RS12395	COG0582	viral genome integration into host DNA
HHO38_RS12435	COG3279	Response regulator of the LytR AlgR family
HHO38_RS12480	COG3537	Alpha-1,2-mannosidase
HHO38_RS12485	COG0702	epimerase
HHO38_RS12490	COG4771	TonB-dependent receptor
HHO38_RS12505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHO38_RS12525	COG0335	large ribosomal subunit rRNA binding
HHO38_RS12595	COG0148	phosphopyruvate hydratase activity
HHO38_RS12600	COG0203	ribosomal protein L17
HHO38_RS12605	COG0202	RNA polymerase activity
HHO38_RS12610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHO38_RS12615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHO38_RS12620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHO38_RS12625	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHO38_RS12630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHO38_RS12640	COG0201	protein transport
HHO38_RS12645	COG0200	Binds to the 23S rRNA
HHO38_RS12650	COG1841	ribosomal large subunit assembly
HHO38_RS12655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HHO38_RS12660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHO38_RS12665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HHO38_RS12670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HHO38_RS12675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHO38_RS12680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HHO38_RS12685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HHO38_RS12690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HHO38_RS12695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HHO38_RS12700	COG0255	Belongs to the universal ribosomal protein uL29 family
HHO38_RS12705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HHO38_RS12710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHO38_RS12715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HHO38_RS12720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHO38_RS12725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHO38_RS12730	COG0089	rRNA binding
HHO38_RS12735	COG0088	Forms part of the polypeptide exit tunnel
HHO38_RS12740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HHO38_RS12745	COG0051	transcription antitermination factor activity, RNA binding
HHO38_RS12750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHO38_RS12755	COG0049	tRNA binding
HHO38_RS12760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HHO38_RS12775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHO38_RS12800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHO38_RS12805	COG0516	GMP reductase activity
HHO38_RS12805	COG0517	IMP dehydrogenase activity
HHO38_RS12810	COG0514	ATP-dependent DNA helicase (RecQ)
HHO38_RS12815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HHO38_RS12820	COG0740	serine-type endopeptidase activity
HHO38_RS12825	COG0544	peptidyl-prolyl cis-trans isomerase activity
HHO38_RS12835	COG1137	ATPase activity
HHO38_RS12845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHO38_RS12850	COG1127	ABC transporter
HHO38_RS12855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HHO38_RS12865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HHO38_RS12865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HHO38_RS12870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HHO38_RS12875	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HHO38_RS12880	COG1968	undecaprenyl-diphosphatase activity
HHO38_RS12890	COG2177	Part of the ABC transporter FtsEX involved in
HHO38_RS12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHO38_RS12945	COG0427	acetyl-CoA hydrolase
HHO38_RS12950	COG0573	inorganic phosphate transmembrane transporter activity
HHO38_RS12955	COG0581	inorganic phosphate transmembrane transporter activity
HHO38_RS12960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHO38_RS12990	COG1132	(ABC) transporter
HHO38_RS13015	COG1472	Belongs to the glycosyl hydrolase 3 family
HHO38_RS13060	COG1160	GTP binding
HHO38_RS13065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HHO38_RS13070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHO38_RS13225	COG0561	phosphatase activity
HHO38_RS13230	COG4771	TonB-dependent receptor
HHO38_RS13245	COG3940	Belongs to the glycosyl hydrolase 43 family
HHO38_RS13265	COG4771	TonB-dependent receptor
HHO38_RS13295	COG1966	Carbon starvation protein
HHO38_RS13300	COG1610	YqeY-like protein
HHO38_RS13305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HHO38_RS13315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHO38_RS13320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHO38_RS13325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHO38_RS13330	COG0772	Belongs to the SEDS family
HHO38_RS13335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHO38_RS13340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHO38_RS13345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHO38_RS13350	COG0768	penicillin binding
HHO38_RS13360	COG0275	rRNA processing
HHO38_RS13390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHO38_RS13395	COG0742	ribosomal rna small subunit methyltransferase
HHO38_RS13420	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HHO38_RS13435	COG1477	protein flavinylation
HHO38_RS13440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HHO38_RS13455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHO38_RS13480	COG4771	TonB-dependent receptor
HHO38_RS13490	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHO38_RS13495	COG1506	peptidase
HHO38_RS13500	COG4771	TonB-dependent receptor
HHO38_RS13510	COG0047	phosphoribosylformylglycinamidine synthase activity
HHO38_RS13510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHO38_RS13545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHO38_RS13550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHO38_RS13555	COG0739	heme binding
HHO38_RS13580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHO38_RS13590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHO38_RS13650	COG1136	(ABC) transporter
HHO38_RS13675	COG0348	domain, Protein
HHO38_RS13695	COG1657	PFAM Prenyltransferase squalene oxidase
HHO38_RS13705	COG0142	geranyltranstransferase activity
HHO38_RS13725	COG3279	Response regulator of the LytR AlgR family
HHO38_RS13735	COG3942	CHAP domain
HHO38_RS13735	COG1388	LysM domain
HHO38_RS13745	COG1475	DNA binding
HHO38_RS13750	COG1192	Involved in chromosome partitioning
HHO38_RS13770	COG0792	nuclease activity
HHO38_RS13795	COG0688	phosphatidylethanolamine metabolic process
HHO38_RS13800	COG1074	ATP-dependent DNA helicase activity
HHO38_RS13815	COG0784	Response regulator, receiver
HHO38_RS13815	COG2205	protein histidine kinase activity
HHO38_RS13815	COG5002	protein histidine kinase activity
HHO38_RS13820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HHO38_RS13835	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHO38_RS13840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HHO38_RS13855	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHO38_RS13865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HHO38_RS13870	COG2239	Acts as a magnesium transporter
HHO38_RS13880	COG1346	cytolysis
HHO38_RS13885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HHO38_RS13890	COG2003	Belongs to the UPF0758 family
HHO38_RS13905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HHO38_RS13915	COG0167	dihydroorotate dehydrogenase activity
HHO38_RS13965	COG1730	sister chromatid segregation
HHO38_RS14005	COG3119	arylsulfatase activity
HHO38_RS14010	COG1280	lysine exporter protein (LysE YggA)
HHO38_RS14035	COG0784	Response regulator, receiver
HHO38_RS14035	COG2198	Histidine kinase
HHO38_RS14035	COG2205	protein histidine kinase activity
HHO38_RS14060	COG0546	phosphoglycolate phosphatase activity
HHO38_RS14070	COG0776	regulation of translation
HHO38_RS14080	COG0673	inositol 2-dehydrogenase activity
HHO38_RS14110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHO38_RS14130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HHO38_RS14135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHO38_RS14175	COG0673	inositol 2-dehydrogenase activity
HHO38_RS14200	COG1271	oxidase subunit
HHO38_RS14215	COG1234	tRNA 3'-trailer cleavage
HHO38_RS14240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HHO38_RS14250	COG4772	TonB-dependent receptor
HHO38_RS14260	COG0632	four-way junction helicase activity
HHO38_RS14270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHO38_RS14275	COG0569	domain protein
HHO38_RS14280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HHO38_RS14295	COG0483	inositol monophosphate 1-phosphatase activity
HHO38_RS14370	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHO38_RS14375	COG0564	pseudouridine synthase activity
HHO38_RS14380	COG2815	serine threonine protein kinase
HHO38_RS14380	COG0515	serine threonine protein kinase
HHO38_RS14385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HHO38_RS14425	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHO38_RS14430	COG1196	nuclear chromosome segregation
HHO38_RS14440	COG2382	esterase
HHO38_RS14450	COG3279	Response regulator of the LytR AlgR family
HHO38_RS14485	COG0302	gtp cyclohydrolase
HHO38_RS14495	COG0149	triose-phosphate isomerase activity
HHO38_RS14510	COG0739	heme binding
HHO38_RS14515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHO38_RS14530	COG1570	exodeoxyribonuclease VII activity
HHO38_RS14540	COG1522	sequence-specific DNA binding
HHO38_RS14545	COG0545	Peptidyl-prolyl cis-trans isomerase
HHO38_RS14555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HHO38_RS14585	COG1757	Na H antiporter
HHO38_RS14590	COG1757	Na H antiporter
HHO38_RS14605	COG0793	Belongs to the peptidase S41A family
HHO38_RS14605	COG4946	Tricorn protease homolog
HHO38_RS14630	COG3275	phosphorelay sensor kinase activity
HHO38_RS14645	COG2431	L-lysine efflux transmembrane transporter activity
HHO38_RS14670	COG0393	Putative heavy-metal-binding
HHO38_RS14725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS14730	COG4206	TonB-dependent receptor
HHO38_RS14730	COG1629	transport
HHO38_RS14745	COG0673	inositol 2-dehydrogenase activity
HHO38_RS14750	COG3292	Two component regulator propeller
HHO38_RS14750	COG2205	protein histidine kinase activity
HHO38_RS14750	COG0745	RESPONSE REGULATOR receiver
HHO38_RS14785	COG0582	viral genome integration into host DNA
HHO38_RS14815	COG1022	Amp-dependent synthetase and ligase
HHO38_RS14820	COG1695	Transcriptional regulator
HHO38_RS14835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HHO38_RS14845	COG1185	polyribonucleotide nucleotidyltransferase activity
HHO38_RS14890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HHO38_RS14890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HHO38_RS14915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHO38_RS14925	COG0318	PFAM AMP-dependent synthetase and ligase
HHO38_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS14940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HHO38_RS14945	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS14995	COG0562	UDP-galactopyranose mutase
HHO38_RS15000	COG2244	polysaccharide biosynthetic process
HHO38_RS15025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHO38_RS15025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHO38_RS15075	COG1917	Cupin 2, conserved barrel domain protein
HHO38_RS15075	COG4977	sequence-specific DNA binding
HHO38_RS15080	COG0606	chelatase, subunit chli
HHO38_RS15090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HHO38_RS15095	COG1013	pyruvate-flavodoxin oxidoreductase activity
HHO38_RS15100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HHO38_RS15100	COG0674	pyruvate-flavodoxin oxidoreductase activity
HHO38_RS15105	COG0686	Belongs to the AlaDH PNT family
HHO38_RS15110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHO38_RS15135	COG0328	RNA-DNA hybrid ribonuclease activity
HHO38_RS15135	COG3341	Caulimovirus viroplasmin
HHO38_RS15190	COG1404	Belongs to the peptidase S8 family
HHO38_RS15215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHO38_RS15220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHO38_RS15225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHO38_RS15230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHO38_RS15235	COG0571	ribonuclease III activity
HHO38_RS15245	COG0205	6-phosphofructokinase activity
HHO38_RS15260	COG5434	Belongs to the glycosyl hydrolase 28 family
HHO38_RS15290	COG1136	(ABC) transporter
HHO38_RS15295	COG0215	cysteine-tRNA ligase activity
HHO38_RS15380	COG3227	Zinc metalloprotease (Elastase)
HHO38_RS15390	COG3590	peptidase
HHO38_RS15400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HHO38_RS15405	COG0681	Belongs to the peptidase S26 family
HHO38_RS15420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HHO38_RS15425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHO38_RS15535	COG3023	N-Acetylmuramoyl-L-alanine amidase
HHO38_RS15545	COG4206	TonB-dependent receptor
HHO38_RS15545	COG1629	transport
HHO38_RS15550	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS15565	COG0363	glucosamine-6-phosphate deaminase activity
HHO38_RS15570	COG1940	carbohydrate kinase activity
HHO38_RS15580	COG4948	Mandelate Racemase Muconate Lactonizing
HHO38_RS15585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHO38_RS15590	COG1136	(ABC) transporter
HHO38_RS15630	COG0733	neurotransmitter:sodium symporter activity
HHO38_RS15675	COG1629	transport
HHO38_RS15675	COG4206	TonB-dependent receptor
HHO38_RS15680	COG1115	amino acid carrier protein
HHO38_RS15690	COG0612	Peptidase, M16
HHO38_RS15705	COG0517	IMP dehydrogenase activity
HHO38_RS15705	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HHO38_RS15710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHO38_RS15725	COG1506	peptidase
HHO38_RS15725	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS15740	COG3591	Belongs to the peptidase S1B family
HHO38_RS15750	COG2205	protein histidine kinase activity
HHO38_RS15750	COG2202	Pas domain
HHO38_RS15760	COG2255	four-way junction helicase activity
HHO38_RS15790	COG2197	response regulator
HHO38_RS15795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHO38_RS15825	COG0438	transferase activity, transferring glycosyl groups
HHO38_RS15830	COG1442	glycosyl transferase family 8
HHO38_RS15830	COG1216	Glycosyl transferase, family 2
HHO38_RS15845	COG1216	Glycosyl transferase, family 2
HHO38_RS15870	COG1940	carbohydrate kinase activity
HHO38_RS15875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHO38_RS15890	COG4771	TonB-dependent receptor
HHO38_RS15895	COG0702	epimerase
HHO38_RS15905	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHO38_RS15910	COG2755	lipolytic protein G-D-S-L family
HHO38_RS15910	COG0657	acetylesterase activity
HHO38_RS15915	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HHO38_RS15930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHO38_RS15935	COG1611	Belongs to the LOG family
HHO38_RS15950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHO38_RS15955	COG2715	membrane protein required for spore maturation
HHO38_RS15960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HHO38_RS15980	COG0445	tRNA wobble uridine modification
HHO38_RS15985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HHO38_RS15990	COG0322	excinuclease ABC activity
HHO38_RS15995	COG1490	D-aminoacyl-tRNA deacylase activity
HHO38_RS16000	COG1694	Mazg nucleotide pyrophosphohydrolase
HHO38_RS16010	COG0142	geranyltranstransferase activity
HHO38_RS16015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHO38_RS16015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHO38_RS16035	COG4771	TonB-dependent receptor
HHO38_RS16040	COG0702	epimerase
HHO38_RS16055	COG0012	GTP binding
HHO38_RS16060	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS16065	COG2207	Transcriptional regulator
HHO38_RS16110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHO38_RS16115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHO38_RS16160	COG0495	leucyl-tRNA aminoacylation
HHO38_RS16170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHO38_RS16190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HHO38_RS16205	COG3645	SOS response
HHO38_RS16220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHO38_RS16220	COG0731	radical SAM domain protein
HHO38_RS16225	COG3250	beta-galactosidase activity
HHO38_RS16280	COG2133	pyrroloquinoline quinone binding
HHO38_RS16280	COG5183	chlorophyll binding
HHO38_RS16285	COG0659	secondary active sulfate transmembrane transporter activity
HHO38_RS16290	COG1592	Rubrerythrin
HHO38_RS16295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HHO38_RS16300	COG4771	TonB-dependent receptor
HHO38_RS16305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS16320	COG1629	transport
HHO38_RS16320	COG4206	TonB-dependent receptor
HHO38_RS16325	COG0702	epimerase
HHO38_RS16330	COG0534	Mate efflux family protein
HHO38_RS16390	COG0594	ribonuclease P activity
HHO38_RS16395	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHO38_RS16405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHO38_RS16410	COG1191	sigma factor activity
HHO38_RS16425	COG1629	transport
HHO38_RS16425	COG4206	TonB-dependent receptor
HHO38_RS16430	COG0702	epimerase
HHO38_RS16445	COG4771	TonB-dependent receptor
HHO38_RS16450	COG0702	epimerase
HHO38_RS16500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHO38_RS16505	COG0612	Peptidase, M16
HHO38_RS16520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHO38_RS16540	COG1121	(ABC) transporter
HHO38_RS16550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS16615	COG0681	Belongs to the peptidase S26 family
HHO38_RS16640	COG1045	serine acetyltransferase
HHO38_RS16645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHO38_RS16645	COG0116	Belongs to the methyltransferase superfamily
HHO38_RS16650	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS16650	COG1506	peptidase
HHO38_RS16655	COG0151	Belongs to the GarS family
HHO38_RS16660	COG3408	Glycogen debranching enzyme
HHO38_RS16680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHO38_RS16685	COG0196	riboflavin kinase activity
HHO38_RS16690	COG1595	DNA-templated transcription, initiation
HHO38_RS16700	COG2205	protein histidine kinase activity
HHO38_RS16700	COG0745	RESPONSE REGULATOR receiver
HHO38_RS16700	COG3292	Two component regulator propeller
HHO38_RS16705	COG1501	Belongs to the glycosyl hydrolase 31 family
HHO38_RS16710	COG3250	beta-galactosidase activity
HHO38_RS16715	COG1472	Belongs to the glycosyl hydrolase 3 family
HHO38_RS16720	COG2837	iron assimilation
HHO38_RS16755	COG1629	transport
HHO38_RS16755	COG4206	TonB-dependent receptor
HHO38_RS16775	COG4206	TonB-dependent receptor
HHO38_RS16775	COG1629	transport
HHO38_RS16795	COG1595	DNA-templated transcription, initiation
HHO38_RS16805	COG4771	TonB-dependent receptor
HHO38_RS16825	COG3250	beta-galactosidase activity
HHO38_RS16840	COG4771	TonB-dependent receptor
HHO38_RS16845	COG0702	epimerase
HHO38_RS16860	COG1929	Belongs to the glycerate kinase type-1 family
HHO38_RS16865	COG2610	gluconate transmembrane transporter activity
HHO38_RS16870	COG2311	Membrane
HHO38_RS16885	COG4771	TonB-dependent receptor
HHO38_RS16890	COG0702	epimerase
HHO38_RS16910	COG4771	TonB-dependent receptor
HHO38_RS16915	COG0702	epimerase
HHO38_RS16920	COG3537	Alpha-1,2-mannosidase
HHO38_RS16935	COG1595	DNA-templated transcription, initiation
HHO38_RS16945	COG4771	TonB-dependent receptor
HHO38_RS16980	COG3250	beta-galactosidase activity
HHO38_RS16985	COG3537	Alpha-1,2-mannosidase
HHO38_RS17000	COG3537	Alpha-1,2-mannosidase
HHO38_RS17015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HHO38_RS17025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHO38_RS17035	COG0024	Methionine aminopeptidase
HHO38_RS17045	COG1228	amidohydrolase
HHO38_RS17135	COG0509	glycine decarboxylation via glycine cleavage system
HHO38_RS17140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHO38_RS17145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HHO38_RS17150	COG0756	dUTP diphosphatase activity
HHO38_RS17205	COG1904	glucuronate isomerase
HHO38_RS17225	COG0826	peptidase U32
HHO38_RS17235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHO38_RS17235	COG0758	DNA mediated transformation
HHO38_RS17290	COG3546	catalase activity
HHO38_RS17300	COG2885	chlorophyll binding
HHO38_RS17310	COG1595	DNA-templated transcription, initiation
HHO38_RS17320	COG0673	inositol 2-dehydrogenase activity
HHO38_RS17325	COG0423	glycine-tRNA ligase activity
HHO38_RS17335	COG3279	Response regulator of the LytR AlgR family
HHO38_RS17345	COG0784	Response regulator, receiver
HHO38_RS17345	COG2198	Histidine kinase
HHO38_RS17345	COG2205	protein histidine kinase activity
HHO38_RS17365	COG1053	succinate dehydrogenase
HHO38_RS17395	COG1629	transport
HHO38_RS17395	COG4206	TonB-dependent receptor
HHO38_RS17410	COG1752	Esterase of the alpha-beta hydrolase superfamily
HHO38_RS17430	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HHO38_RS17445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHO38_RS17530	COG1649	PFAM Uncharacterised BCR, COG1649
HHO38_RS17550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHO38_RS17560	COG2207	Transcriptional regulator
HHO38_RS17560	COG0662	Cupin 2, conserved barrel domain protein
HHO38_RS17565	COG2140	Oxalate decarboxylase
HHO38_RS17570	COG1940	carbohydrate kinase activity
HHO38_RS17580	COG2814	Major facilitator Superfamily
HHO38_RS17595	COG4771	TonB-dependent receptor
HHO38_RS17610	COG4974	Belongs to the 'phage' integrase family
HHO38_RS17615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HHO38_RS17630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HHO38_RS17635	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHO38_RS17650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHO38_RS17665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHO38_RS17685	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HHO38_RS17755	COG4974	Belongs to the 'phage' integrase family
HHO38_RS17760	COG4974	Belongs to the 'phage' integrase family
HHO38_RS17765	COG1431	PFAM Stem cell self-renewal protein Piwi
HHO38_RS17815	COG2204	response regulator
HHO38_RS17820	COG0784	Response regulator, receiver
HHO38_RS17820	COG2205	protein histidine kinase activity
HHO38_RS17830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHO38_RS17855	COG2382	esterase
HHO38_RS17855	COG3507	Belongs to the glycosyl hydrolase 43 family
HHO38_RS17855	COG3693	PFAM glycoside hydrolase, family 10
HHO38_RS17870	COG2207	Transcriptional regulator
HHO38_RS17870	COG4753	response regulator
HHO38_RS17875	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHO38_RS17890	COG0667	Aldo Keto reductase
HHO38_RS17905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHO38_RS17935	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
HHO38_RS17940	COG1011	Hydrolase
HHO38_RS17965	COG2197	response regulator
HHO38_RS17970	COG3665	Urea carboxylase-associated protein
HHO38_RS17980	COG0477	Major facilitator Superfamily
HHO38_RS18010	COG2003	Belongs to the UPF0758 family
HHO38_RS18030	COG0628	permease
HHO38_RS18035	COG2027	D-alanyl-D-alanine carboxypeptidase
HHO38_RS18040	COG3279	Response regulator of the LytR AlgR family
HHO38_RS18045	COG2972	Histidine kinase
HHO38_RS18050	COG1136	(ABC) transporter
HHO38_RS18050	COG0577	efflux transmembrane transporter activity
HHO38_RS18055	COG1136	(ABC) transporter
HHO38_RS18060	COG1566	PFAM secretion protein HlyD family protein
HHO38_RS18070	COG2059	Chromate
HHO38_RS18080	COG0793	Belongs to the peptidase S41A family
HHO38_RS18085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HHO38_RS18105	COG0557	exoribonuclease II activity
HHO38_RS18115	COG0802	atpase or kinase
HHO38_RS18120	COG2204	response regulator
HHO38_RS18135	COG1629	transport
HHO38_RS18140	COG0702	epimerase
HHO38_RS18160	COG4206	TonB-dependent receptor
HHO38_RS18160	COG1629	transport
HHO38_RS18185	COG3263	regulation of cellular component size
HHO38_RS18235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHO38_RS18265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHO38_RS18280	COG2096	Adenosyltransferase
HHO38_RS18295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHO38_RS18315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHO38_RS18320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HHO38_RS18325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HHO38_RS18330	COG0280	phosphate acetyltransferase
HHO38_RS18335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HHO38_RS18340	COG0528	UMP kinase activity
HHO38_RS18345	COG0745	RESPONSE REGULATOR receiver
HHO38_RS18345	COG3292	Two component regulator propeller
HHO38_RS18345	COG2205	protein histidine kinase activity
HHO38_RS18350	COG1621	beta-fructofuranosidase activity
HHO38_RS18365	COG0233	cytoplasmic translational termination
HHO38_RS18370	COG1162	GTPase activity
HHO38_RS18375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HHO38_RS18380	COG1629	transport
HHO38_RS18390	COG3250	beta-galactosidase activity
HHO38_RS18395	COG0009	L-threonylcarbamoyladenylate synthase
HHO38_RS18400	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHO38_RS18405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HHO38_RS18420	COG3537	Alpha-1,2-mannosidase
HHO38_RS18430	COG4771	TonB-dependent receptor
HHO38_RS18435	COG3292	Two component regulator propeller
HHO38_RS18435	COG0745	RESPONSE REGULATOR receiver
HHO38_RS18435	COG2205	protein histidine kinase activity
HHO38_RS18450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHO38_RS18465	COG3634	alkyl hydroperoxide reductase activity
HHO38_RS18475	COG4771	TonB-dependent receptor
HHO38_RS18535	COG4771	TonB-dependent receptor
HHO38_RS18610	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHO38_RS18630	COG3307	-O-antigen
HHO38_RS18635	COG0681	Belongs to the peptidase S26 family
HHO38_RS18705	COG0180	Tryptophanyl-tRNA synthetase
HHO38_RS18725	COG4771	TonB-dependent receptor
HHO38_RS18775	COG4191	Histidine kinase
HHO38_RS18800	COG4106	trans-aconitate 2-methyltransferase activity
HHO38_RS18805	COG3153	acetyltransferase
HHO38_RS18815	COG3292	Two component regulator propeller
HHO38_RS18815	COG2205	protein histidine kinase activity
HHO38_RS18815	COG0745	RESPONSE REGULATOR receiver
HHO38_RS18840	COG5000	phosphorelay sensor kinase activity
HHO38_RS18845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS18845	COG0784	Response regulator, receiver
HHO38_RS18845	COG2205	protein histidine kinase activity
HHO38_RS18845	COG2198	Histidine kinase
HHO38_RS18855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HHO38_RS18855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHO38_RS18860	COG3118	belongs to the thioredoxin family
HHO38_RS18880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHO38_RS18885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HHO38_RS18890	COG0052	Belongs to the universal ribosomal protein uS2 family
HHO38_RS18895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HHO38_RS18900	COG0436	Aminotransferase
HHO38_RS18905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHO38_RS18905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HHO38_RS18930	COG3292	Two component regulator propeller
HHO38_RS18930	COG2205	protein histidine kinase activity
HHO38_RS18930	COG0745	RESPONSE REGULATOR receiver
HHO38_RS18960	COG4974	Belongs to the 'phage' integrase family
HHO38_RS18965	COG4974	Belongs to the 'phage' integrase family
HHO38_RS19115	COG0779	Required for maturation of 30S ribosomal subunits
HHO38_RS19120	COG2251	uridine kinase activity
HHO38_RS19120	COG0195	Participates in both transcription termination and antitermination
HHO38_RS19125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHO38_RS19135	COG0719	Fe-S assembly protein
HHO38_RS19140	COG0396	ATPase activity
HHO38_RS19145	COG0719	Fe-S assembly protein
HHO38_RS19150	COG0346	lactoylglutathione lyase activity
HHO38_RS19155	COG0366	Alpha amylase catalytic
HHO38_RS19170	COG3119	arylsulfatase activity
HHO38_RS19175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHO38_RS19185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHO38_RS19190	COG2166	iron-sulfur cluster assembly
HHO38_RS19200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HHO38_RS19205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HHO38_RS19210	COG0187	DNA topoisomerase II activity
HHO38_RS19220	COG0268	Binds directly to 16S ribosomal RNA
HHO38_RS19235	COG1381	Involved in DNA repair and RecF pathway recombination
HHO38_RS19325	COG0305	Participates in initiation and elongation during chromosome replication
HHO38_RS19370	COG2172	sigma factor antagonist activity
HHO38_RS19375	COG1366	Belongs to the anti-sigma-factor antagonist family
HHO38_RS19385	COG0673	inositol 2-dehydrogenase activity
HHO38_RS19395	COG1408	metallophosphoesterase
HHO38_RS19400	COG0673	inositol 2-dehydrogenase activity
HHO38_RS19405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HHO38_RS19415	COG0363	glucosamine-6-phosphate deaminase activity
HHO38_RS19430	COG4771	TonB-dependent receptor
HHO38_RS19460	COG1136	(ABC) transporter
HHO38_RS19465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHO38_RS19490	COG0702	epimerase
HHO38_RS19495	COG1629	transport
HHO38_RS19495	COG4206	TonB-dependent receptor
HHO38_RS19500	COG4771	TonB-dependent receptor
HHO38_RS19520	COG1940	carbohydrate kinase activity
HHO38_RS19540	COG3852	Histidine kinase
HHO38_RS19545	COG4251	negative regulation of phosphorylation
HHO38_RS19550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHO38_RS19550	COG4191	Histidine kinase
HHO38_RS19555	COG2208	phosphoserine phosphatase activity
HHO38_RS19555	COG2770	Histidine kinase
HHO38_RS19600	COG0018	arginyl-trna synthetase
HHO38_RS19635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHO38_RS19640	COG4974	Belongs to the 'phage' integrase family
HHO38_RS19695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HHO38_RS19710	COG3754	Rhamnan synthesis protein F
HHO38_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS19730	COG0318	PFAM AMP-dependent synthetase and ligase
HHO38_RS19755	COG1091	dTDP-4-dehydrorhamnose reductase activity
HHO38_RS19760	COG0297	glycogen (starch) synthase activity
HHO38_RS19770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHO38_RS19770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHO38_RS19780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHO38_RS19795	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HHO38_RS19805	COG1228	amidohydrolase
HHO38_RS19810	COG3404	Formiminotransferase-cyclodeaminase
HHO38_RS19815	COG2986	histidine ammonia-lyase
HHO38_RS19825	COG0489	protein tyrosine kinase activity
HHO38_RS19830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHO38_RS19855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHO38_RS19860	COG0793	Belongs to the peptidase S41A family
HHO38_RS19865	COG1408	metallophosphoesterase
HHO38_RS19870	COG1408	metallophosphoesterase
HHO38_RS19875	COG0745	RESPONSE REGULATOR receiver
HHO38_RS19880	COG2205	protein histidine kinase activity
HHO38_RS19905	COG2274	protein secretion by the type I secretion system
HHO38_RS19945	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HHO38_RS19955	COG0702	epimerase
HHO38_RS19960	COG4206	TonB-dependent receptor
HHO38_RS19960	COG1629	transport
HHO38_RS19965	COG4206	TonB-dependent receptor
HHO38_RS19965	COG1629	transport
HHO38_RS19970	COG0561	phosphatase activity
HHO38_RS19985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHO38_RS19990	COG1120	ATPase activity
HHO38_RS19995	COG0534	Mate efflux family protein
HHO38_RS20005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HHO38_RS20015	COG0493	'glutamate synthase
HHO38_RS20050	COG0165	Argininosuccinate lyase
HHO38_RS20060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHO38_RS20070	COG2137	regulation of response to DNA damage stimulus
HHO38_RS20075	COG2890	protein-(glutamine-N5) methyltransferase activity
HHO38_RS20080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHO38_RS20080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHO38_RS20095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HHO38_RS20100	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHO38_RS20115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HHO38_RS20120	COG3304	Inner membrane component domain
HHO38_RS20125	COG0739	heme binding
HHO38_RS20125	COG0741	lytic transglycosylase activity
HHO38_RS20125	COG1196	nuclear chromosome segregation
HHO38_RS20130	COG0534	Mate efflux family protein
HHO38_RS20145	COG4771	TonB-dependent receptor
HHO38_RS20150	COG3876	Protein conserved in bacteria
HHO38_RS20155	COG1506	peptidase
HHO38_RS20155	COG0823	Involved in the tonB-independent uptake of proteins
HHO38_RS20170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HHO38_RS20175	COG2502	aspartate--ammonia ligase
HHO38_RS20230	COG1187	pseudouridine synthase activity
HHO38_RS20235	COG0017	Asparaginyl-tRNA synthetase
HHO38_RS20240	COG1522	sequence-specific DNA binding
HHO38_RS20265	COG0811	peptide transport
HHO38_RS20275	COG0084	hydrolase, TatD family'
HHO38_RS20295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HHO38_RS20300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HHO38_RS20305	COG0205	6-phosphofructokinase activity
HHO38_RS20320	COG1703	isobutyryl-CoA mutase activity
HHO38_RS20335	COG2373	Large extracellular alpha-helical protein
HHO38_RS20340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHO38_RS20345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HHO38_RS20360	COG2885	chlorophyll binding
HHO38_RS20360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHO38_RS20390	COG3591	Belongs to the peptidase S1B family
HHO38_RS20405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHO38_RS20410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHO38_RS20425	COG2873	o-acetylhomoserine
HHO38_RS20445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HHO38_RS20450	COG1752	Esterase of the alpha-beta hydrolase superfamily
HHO38_RS20455	COG0366	Alpha amylase catalytic
HHO38_RS20465	COG0586	Pfam SNARE associated Golgi protein
HHO38_RS20475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HHO38_RS20480	COG0482	sulfurtransferase activity
HHO38_RS20500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHO38_RS20510	COG0124	histidyl-tRNA synthetase
HHO38_RS20520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HHO38_RS20525	COG0459	protein refolding
HHO38_RS20550	COG3956	TIGRFAM MazG family protein
HHO38_RS20560	COG0564	pseudouridine synthase activity
HHO38_RS20565	COG0525	valine-tRNA ligase activity
HHO38_RS20570	COG2205	protein histidine kinase activity
HHO38_RS20570	COG0784	Response regulator, receiver
HHO38_RS20580	COG5002	protein histidine kinase activity
HHO38_RS20615	COG0582	viral genome integration into host DNA
HHO38_RS20705	COG4771	TonB-dependent receptor
HHO38_RS20710	COG0702	epimerase
HHO38_RS20715	COG3119	arylsulfatase activity
HHO38_RS20720	COG3119	arylsulfatase activity
HHO38_RS20725	COG3119	arylsulfatase activity
HHO38_RS20740	COG1629	transport
HHO38_RS20740	COG4206	TonB-dependent receptor
HHO38_RS20765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHO38_RS20810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHO38_RS20815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHO38_RS20815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HHO38_RS20830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHO38_RS20835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHO38_RS20875	COG1480	7TM receptor with intracellular HD hydrolase
HHO38_RS20880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHO38_RS20905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HHO38_RS20910	COG0006	proline dipeptidase activity
HHO38_RS20925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HHO38_RS20930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HHO38_RS20935	COG4974	Belongs to the 'phage' integrase family
HHO38_RS20940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHO38_RS20965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHO38_RS20980	COG0250	Participates in transcription elongation, termination and antitermination
HHO38_RS20985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHO38_RS20990	COG0081	regulation of translation
HHO38_RS20995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HHO38_RS21000	COG0222	ribosome binding
HHO38_RS21005	COG0085	RNA polymerase activity
HHO38_RS21010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHO38_RS21020	COG2207	Transcriptional regulator
HHO38_RS21035	COG3850	Histidine kinase
HHO38_RS21035	COG5002	protein histidine kinase activity
HHO38_RS21040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HHO38_RS21045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHO38_RS21050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHO38_RS21070	COG1012	belongs to the aldehyde dehydrogenase family
HHO38_RS21080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHO38_RS21120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HHO38_RS21140	COG1242	4 iron, 4 sulfur cluster binding
HHO38_RS21150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HHO38_RS21165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HHO38_RS21185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HHO38_RS21195	COG3537	Alpha-1,2-mannosidase
HHO38_RS21200	COG0534	Mate efflux family protein
HHO38_RS21210	COG0564	pseudouridine synthase activity
HHO38_RS21245	COG1028	Short-chain dehydrogenase reductase Sdr
HHO38_RS21250	COG1090	epimerase
HHO38_RS21270	COG1063	alcohol dehydrogenase
HHO38_RS21280	COG2184	nucleotidyltransferase activity
HHO38_RS21305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HHO38_RS21330	COG0693	protein deglycase activity
HHO38_RS21430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HHO38_RS21435	COG4804	nuclease activity
HHO38_RS21440	COG0732	type I restriction modification DNA specificity domain
HHO38_RS21485	COG1910	domain protein
HHO38_RS21505	COG4974	Belongs to the 'phage' integrase family
HHO38_RS21705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HHO38_RS21775	COG3530	Putative quorum-sensing-regulated virulence factor
HHO38_RS21845	COG4974	Belongs to the 'phage' integrase family
HHO38_RS21850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHO38_RS21870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHO38_RS21875	COG0813	purine-nucleoside phosphorylase activity
HHO38_RS21880	COG4864	UPF0365 protein
HHO38_RS21895	COG0037	tRNA processing
HHO38_RS21905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HHO38_RS21920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHO38_RS21925	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHO38_RS21925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHO38_RS21930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHO38_RS21935	COG0284	orotidine-5'-phosphate decarboxylase activity
HHO38_RS21940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HHO38_RS21945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHO38_RS21950	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHO38_RS21960	COG0295	cytidine deaminase activity
HHO38_RS21965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHO38_RS21970	COG0739	heme binding
HHO38_RS21975	COG0259	pyridoxamine-phosphate oxidase activity
HHO38_RS21990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HHO38_RS22015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHO38_RS22020	COG1012	belongs to the aldehyde dehydrogenase family
HHO38_RS22035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HHO38_RS22040	COG2076	Multidrug Resistance protein
HHO38_RS22045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHO38_RS22050	COG1047	Peptidyl-prolyl cis-trans
HHO38_RS22055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HHO38_RS22060	COG0129	dihydroxy-acid dehydratase activity
HHO38_RS22065	COG0028	Belongs to the TPP enzyme family
HHO38_RS22080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHO38_RS22095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHO38_RS22100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHO38_RS22105	COG0066	3-isopropylmalate dehydratase activity
HHO38_RS22110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHO38_RS22130	COG0668	transmembrane transport
HHO38_RS22150	COG0517	IMP dehydrogenase activity
HHO38_RS22150	COG0617	tRNA 3'-terminal CCA addition
HHO38_RS22150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHO38_RS22165	COG0673	inositol 2-dehydrogenase activity
HHO38_RS22220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHO38_RS22220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHO38_RS22225	COG0667	Aldo Keto reductase
HHO38_RS22230	COG1073	alpha beta
HHO38_RS22270	COG0488	(ABC) transporter
HHO38_RS22275	COG2814	Major facilitator Superfamily
HHO38_RS22310	COG0436	Aminotransferase
HHO38_RS22325	COG1215	transferase activity, transferring glycosyl groups
HHO38_RS22330	COG0019	diaminopimelate decarboxylase activity
HHO38_RS22335	COG0527	aspartate kinase activity
HHO38_RS22340	COG2884	Cell division ATP-binding protein ftsE
HHO38_RS22345	COG0140	phosphoribosyl-ATP diphosphatase activity
HHO38_RS22345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HHO38_RS22350	COG0107	imidazoleglycerol-phosphate synthase activity
HHO38_RS22355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HHO38_RS22375	COG0778	Nitroreductase
HHO38_RS22385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHO38_RS22405	COG2382	esterase
HHO38_RS22415	COG0058	SHG alpha-glucan phosphorylase activity
HHO38_RS22435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHO38_RS22440	COG2211	Major facilitator Superfamily
HHO38_RS22445	COG5002	protein histidine kinase activity
HHO38_RS22455	COG0443	Heat shock 70 kDa protein
HHO38_RS22460	COG1530	ribonuclease E activity
HHO38_RS22465	COG0776	regulation of translation
HHO38_RS22475	COG0629	single-stranded DNA binding
HHO38_RS22495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHO38_RS22500	COG2226	methyltransferase
HHO38_RS22505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHO38_RS22510	COG1702	phosphate starvation-inducible protein PhoH
HHO38_RS22520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HHO38_RS22545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHO38_RS22555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HHO38_RS22560	COG3250	beta-galactosidase activity
HHO38_RS22580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHO38_RS22595	COG0577	efflux transmembrane transporter activity
HHO38_RS22595	COG1136	(ABC) transporter
HHO38_RS22605	COG1136	(ABC) transporter
HHO38_RS22610	COG0577	efflux transmembrane transporter activity
HHO38_RS22610	COG1136	(ABC) transporter
HHO38_RS22615	COG0577	efflux transmembrane transporter activity
HHO38_RS22615	COG1136	(ABC) transporter
HHO38_RS22620	COG1136	(ABC) transporter
HHO38_RS22620	COG0577	efflux transmembrane transporter activity
HHO38_RS22655	COG3279	Response regulator of the LytR AlgR family
HHO38_RS22665	COG2204	response regulator
HHO38_RS22670	COG3852	Histidine kinase
HHO38_RS22685	COG0254	rRNA binding
HHO38_RS22690	COG0191	fructose-bisphosphate aldolase activity
HHO38_RS22735	COG0681	Belongs to the peptidase S26 family
HHO38_RS22750	COG2814	Major facilitator Superfamily
HHO38_RS22755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHO38_RS22760	COG2315	Protein conserved in bacteria
HHO38_RS22770	COG0490	domain, Protein
HHO38_RS22770	COG2985	domain, Protein
HHO38_RS22775	COG0101	tRNA pseudouridine synthase activity
HHO38_RS22800	COG5002	protein histidine kinase activity
HHO38_RS22805	COG0745	RESPONSE REGULATOR receiver
HHO38_RS22815	COG1595	DNA-templated transcription, initiation
HHO38_RS22845	COG4753	response regulator
HHO38_RS22845	COG2207	Transcriptional regulator
HHO38_RS22850	COG3059	membrane
HHO38_RS22860	COG1629	transport
HHO38_RS22870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHO38_RS22875	COG0500	methyltransferase
HHO38_RS22880	COG2830	Protein of unknown function (DUF452)
HHO38_RS22895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHO38_RS22925	COG4206	TonB-dependent receptor
HHO38_RS22925	COG1629	transport
HHO38_RS22950	COG0673	inositol 2-dehydrogenase activity
HHO38_RS22960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HHO38_RS22960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HHO38_RS22970	COG0563	adenylate kinase activity
HHO38_RS22975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHO38_RS23005	COG1418	mRNA catabolic process
HHO38_RS23010	COG3119	arylsulfatase activity
HHO38_RS23015	COG0488	(ABC) transporter
HHO38_RS23030	COG2361	Protein of unknown function DUF86
HHO38_RS23035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHO38_RS23040	COG0138	bifunctional purine biosynthesis protein purh