locus-tag	class	description
I6J64_RS00015	COG3537	Alpha-1,2-mannosidase
I6J64_RS00020	COG3537	Alpha-1,2-mannosidase
I6J64_RS00055	COG3969	phosphoadenosine phosphosulfate
I6J64_RS00060	COG1475	DNA binding
I6J64_RS00065	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
I6J64_RS00105	COG0339	signal peptide processing
I6J64_RS00110	COG0339	signal peptide processing
I6J64_RS00145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS00200	COG1216	Glycosyl transferase, family 2
I6J64_RS00210	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS00220	COG0673	inositol 2-dehydrogenase activity
I6J64_RS00230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J64_RS00245	COG0105	UTP biosynthetic process
I6J64_RS00270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J64_RS00285	COG0667	Aldo Keto reductase
I6J64_RS00305	COG3590	peptidase
I6J64_RS00325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J64_RS00330	COG4206	TonB-dependent receptor
I6J64_RS00330	COG1629	transport
I6J64_RS00355	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J64_RS00370	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6J64_RS00375	COG0693	protein deglycase activity
I6J64_RS00385	COG0848	biopolymer transport protein
I6J64_RS00390	COG0811	peptide transport
I6J64_RS00395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J64_RS00405	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J64_RS00410	COG1216	Glycosyl transferase, family 2
I6J64_RS00445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS00470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J64_RS00475	COG0488	(ABC) transporter
I6J64_RS00515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J64_RS00535	COG4771	TonB-dependent receptor
I6J64_RS00540	COG0702	epimerase
I6J64_RS00610	COG2233	PERMEase
I6J64_RS00615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J64_RS00640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J64_RS00670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6J64_RS00675	COG0826	peptidase U32
I6J64_RS00700	COG0745	RESPONSE REGULATOR receiver
I6J64_RS00700	COG3292	Two component regulator propeller
I6J64_RS00700	COG2205	protein histidine kinase activity
I6J64_RS00715	COG1506	peptidase
I6J64_RS00715	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS00720	COG1830	Aldolase
I6J64_RS00725	COG1773	rubredoxin
I6J64_RS00725	COG1592	Rubrerythrin
I6J64_RS00735	COG0519	Catalyzes the synthesis of GMP from XMP
I6J64_RS00745	COG0481	GTPase activity
I6J64_RS00750	COG2996	Protein conserved in bacteria
I6J64_RS00765	COG3475	LICD family
I6J64_RS00770	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS00775	COG0297	glycogen (starch) synthase activity
I6J64_RS00790	COG2244	polysaccharide biosynthetic process
I6J64_RS00820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J64_RS00820	COG1918	ferrous iron import across plasma membrane
I6J64_RS00835	COG2264	protein methyltransferase activity
I6J64_RS00850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J64_RS00865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J64_RS00870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J64_RS00875	COG1748	Saccharopine dehydrogenase
I6J64_RS00895	COG0842	Transport permease protein
I6J64_RS00895	COG1131	(ABC) transporter
I6J64_RS00895	COG1716	ATPase activity
I6J64_RS00910	COG4771	TonB-dependent receptor
I6J64_RS00920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J64_RS00925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J64_RS00950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J64_RS00960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J64_RS00965	COG1678	Uncharacterized ACR, COG1678
I6J64_RS00985	COG0110	maltose O-acetyltransferase activity
I6J64_RS01005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J64_RS01015	COG4974	Belongs to the 'phage' integrase family
I6J64_RS01030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS01045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J64_RS01050	COG2244	polysaccharide biosynthetic process
I6J64_RS01055	COG3475	LICD family
I6J64_RS01060	COG5039	Polysaccharide pyruvyl transferase
I6J64_RS01065	COG1216	Glycosyl transferase, family 2
I6J64_RS01075	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS01080	COG0110	maltose O-acetyltransferase activity
I6J64_RS01105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J64_RS01110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J64_RS01120	COG0037	tRNA processing
I6J64_RS01130	COG0513	Belongs to the DEAD box helicase family
I6J64_RS01140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J64_RS01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J64_RS01195	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J64_RS01200	COG3852	Histidine kinase
I6J64_RS01210	COG2814	Major facilitator Superfamily
I6J64_RS01215	COG0534	Mate efflux family protein
I6J64_RS01235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J64_RS01240	COG0436	Aminotransferase
I6J64_RS01250	COG2207	Transcriptional regulator
I6J64_RS01250	COG1609	Transcriptional regulator
I6J64_RS01265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J64_RS01280	COG3842	ATPase activity
I6J64_RS01300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J64_RS01310	COG0693	protein deglycase activity
I6J64_RS01320	COG0673	inositol 2-dehydrogenase activity
I6J64_RS01325	COG1492	cobalamin metabolic process
I6J64_RS01330	COG4974	Belongs to the 'phage' integrase family
I6J64_RS01350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS01360	COG2244	polysaccharide biosynthetic process
I6J64_RS01375	COG1063	alcohol dehydrogenase
I6J64_RS01380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J64_RS01385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J64_RS01395	COG1032	radical SAM domain protein
I6J64_RS01400	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS01420	COG1760	l-serine dehydratase
I6J64_RS01430	COG1309	transcriptional regulator
I6J64_RS01445	COG1131	(ABC) transporter
I6J64_RS01450	COG1131	(ABC) transporter
I6J64_RS01455	COG0842	Transport permease protein
I6J64_RS01465	COG2610	gluconate transmembrane transporter activity
I6J64_RS01505	COG1070	Carbohydrate kinase
I6J64_RS01510	COG4806	L-rhamnose isomerase
I6J64_RS01520	COG0235	Class ii aldolase
I6J64_RS01530	COG3250	beta-galactosidase activity
I6J64_RS01555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J64_RS01585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J64_RS01610	COG0583	DNA-binding transcription factor activity
I6J64_RS01615	COG0463	Glycosyl transferase, family 2
I6J64_RS01620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J64_RS01625	COG0602	queuosine metabolic process
I6J64_RS01640	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS01645	COG0463	Glycosyl transferase, family 2
I6J64_RS01675	COG0358	DNA primase activity
I6J64_RS01680	COG0305	Participates in initiation and elongation during chromosome replication
I6J64_RS01715	COG0110	maltose O-acetyltransferase activity
I6J64_RS01720	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS01800	COG4974	Belongs to the 'phage' integrase family
I6J64_RS01810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J64_RS01810	COG3153	acetyltransferase
I6J64_RS01815	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J64_RS01820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J64_RS01830	COG0488	(ABC) transporter
I6J64_RS01910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J64_RS01915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J64_RS01960	COG0598	Magnesium transport protein CorA
I6J64_RS01965	COG1193	negative regulation of DNA recombination
I6J64_RS01975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J64_RS01980	COG0484	heat shock protein binding
I6J64_RS01985	COG2096	Adenosyltransferase
I6J64_RS01990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J64_RS02000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS02005	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J64_RS02010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J64_RS02010	COG0072	phenylalanine-tRNA ligase activity
I6J64_RS02015	COG0217	transcriptional regulatory protein
I6J64_RS02040	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS02040	COG1506	peptidase
I6J64_RS02040	COG4946	Tricorn protease homolog
I6J64_RS02050	COG3022	response to hydroperoxide
I6J64_RS02060	COG0542	response to heat
I6J64_RS02065	COG2205	protein histidine kinase activity
I6J64_RS02065	COG2202	Pas domain
I6J64_RS02075	COG1360	Flagellar Motor Protein
I6J64_RS02135	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J64_RS02175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J64_RS02180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J64_RS02185	COG4690	dipeptidase activity
I6J64_RS02195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J64_RS02205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J64_RS02230	COG3119	arylsulfatase activity
I6J64_RS02235	COG0667	Aldo Keto reductase
I6J64_RS02245	COG1956	GAF domain-containing protein
I6J64_RS02250	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J64_RS02255	COG1518	maintenance of DNA repeat elements
I6J64_RS02285	COG0534	Mate efflux family protein
I6J64_RS02290	COG2957	Belongs to the agmatine deiminase family
I6J64_RS02300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J64_RS02305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J64_RS02360	COG0514	ATP-dependent DNA helicase (RecQ)
I6J64_RS02365	COG0513	Belongs to the DEAD box helicase family
I6J64_RS02380	COG1629	transport
I6J64_RS02390	COG3119	arylsulfatase activity
I6J64_RS02395	COG0673	inositol 2-dehydrogenase activity
I6J64_RS02400	COG0673	inositol 2-dehydrogenase activity
I6J64_RS02410	COG2205	protein histidine kinase activity
I6J64_RS02410	COG3437	response regulator, receiver
I6J64_RS02410	COG3850	Histidine kinase
I6J64_RS02410	COG4999	Histidine kinase
I6J64_RS02415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J64_RS02430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J64_RS02435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J64_RS02435	COG0321	lipoyl(octanoyl) transferase activity
I6J64_RS02455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J64_RS02460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J64_RS02480	COG4948	Mandelate Racemase Muconate Lactonizing
I6J64_RS02490	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J64_RS02495	COG1169	isochorismate synthase
I6J64_RS02505	COG0561	phosphatase activity
I6J64_RS02510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6J64_RS02520	COG3681	Belongs to the UPF0597 family
I6J64_RS02530	COG0402	S-adenosylhomocysteine deaminase activity
I6J64_RS02545	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J64_RS02550	COG1805	sodium ion transport
I6J64_RS02555	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J64_RS02565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6J64_RS02605	COG0543	2 iron, 2 sulfur cluster binding
I6J64_RS02610	COG0167	dihydroorotate dehydrogenase activity
I6J64_RS02615	COG0708	Exodeoxyribonuclease III
I6J64_RS02655	COG1725	Transcriptional regulator
I6J64_RS02665	COG1131	(ABC) transporter
I6J64_RS02680	COG0006	proline dipeptidase activity
I6J64_RS02705	COG0613	PHP domain protein
I6J64_RS02725	COG0542	response to heat
I6J64_RS02745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J64_RS02750	COG0402	S-adenosylhomocysteine deaminase activity
I6J64_RS02775	COG0531	amino acid
I6J64_RS02790	COG0372	Belongs to the citrate synthase family
I6J64_RS02795	COG0538	isocitrate dehydrogenase activity
I6J64_RS02810	COG2985	domain, Protein
I6J64_RS02815	COG4822	anaerobic cobalamin biosynthetic process
I6J64_RS02845	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6J64_RS02855	COG0351	phosphomethylpyrimidine kinase
I6J64_RS02865	COG0352	thiamine-phosphate diphosphorylase activity
I6J64_RS02870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J64_RS02880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J64_RS02885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J64_RS02895	COG0745	RESPONSE REGULATOR receiver
I6J64_RS02915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS02920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J64_RS02920	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6J64_RS02925	COG1858	cytochrome C peroxidase
I6J64_RS02930	COG1704	LemA family
I6J64_RS02960	COG1045	serine acetyltransferase
I6J64_RS02975	COG0515	serine threonine protein kinase
I6J64_RS03005	COG0784	Response regulator, receiver
I6J64_RS03005	COG5002	protein histidine kinase activity
I6J64_RS03005	COG2205	protein histidine kinase activity
I6J64_RS03010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J64_RS03010	COG0574	Belongs to the PEP-utilizing enzyme family
I6J64_RS03015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J64_RS03020	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J64_RS03040	COG3655	Transcriptional regulator
I6J64_RS03060	COG1902	pentaerythritol trinitrate reductase activity
I6J64_RS03060	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J64_RS03075	COG2207	Transcriptional regulator
I6J64_RS03085	COG1120	ATPase activity
I6J64_RS03110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J64_RS03160	COG1376	ErfK ybiS ycfS ynhG family protein
I6J64_RS03230	COG0442	prolyl-tRNA aminoacylation
I6J64_RS03240	COG0028	Belongs to the TPP enzyme family
I6J64_RS03245	COG1858	cytochrome C peroxidase
I6J64_RS03260	COG3250	beta-galactosidase activity
I6J64_RS03265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J64_RS03280	COG0662	Cupin 2, conserved barrel domain protein
I6J64_RS03280	COG2207	Transcriptional regulator
I6J64_RS03285	COG4753	response regulator
I6J64_RS03285	COG2207	Transcriptional regulator
I6J64_RS03310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS03330	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J64_RS03335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J64_RS03340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J64_RS03345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J64_RS03365	COG0612	Peptidase, M16
I6J64_RS03370	COG0668	transmembrane transport
I6J64_RS03375	COG0668	transmembrane transport
I6J64_RS03415	COG0671	phosphoesterase, PA-phosphatase related
I6J64_RS03435	COG2304	oxidoreductase activity
I6J64_RS03440	COG2304	oxidoreductase activity
I6J64_RS03455	COG0714	Associated with various cellular activities
I6J64_RS03465	COG0776	regulation of translation
I6J64_RS03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J64_RS03475	COG0552	protein localization to endoplasmic reticulum
I6J64_RS03505	COG0724	RNA recognition motif
I6J64_RS03510	COG2373	Large extracellular alpha-helical protein
I6J64_RS03520	COG4953	penicillin-binding protein 1C
I6J64_RS03530	COG0366	Alpha amylase catalytic
I6J64_RS03540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J64_RS03550	COG1739	Uncharacterized protein family UPF0029
I6J64_RS03560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J64_RS03570	COG0531	amino acid
I6J64_RS03585	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J64_RS03590	COG0641	radical SAM
I6J64_RS03595	COG0312	modulator of DNA gyrase
I6J64_RS03605	COG1272	protein, Hemolysin III
I6J64_RS03615	COG2217	Heavy metal translocating P-type atpase
I6J64_RS03635	COG1785	Belongs to the alkaline phosphatase family
I6J64_RS03800	COG4680	protein conserved in bacteria
I6J64_RS03900	COG0629	single-stranded DNA binding
I6J64_RS03945	COG1061	Type III restriction enzyme res subunit
I6J64_RS03955	COG0085	RNA polymerase activity
I6J64_RS04045	COG0540	Belongs to the ATCase OTCase family
I6J64_RS04050	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6J64_RS04065	COG1253	flavin adenine dinucleotide binding
I6J64_RS04070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J64_RS04075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J64_RS04100	COG1269	ATP hydrolysis coupled proton transport
I6J64_RS04115	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6J64_RS04145	COG0477	Major facilitator Superfamily
I6J64_RS04150	COG0076	glutamate decarboxylase activity
I6J64_RS04155	COG2066	Belongs to the glutaminase family
I6J64_RS04180	COG0572	uridine kinase
I6J64_RS04190	COG0671	phosphoesterase, PA-phosphatase related
I6J64_RS04195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J64_RS04215	COG0745	RESPONSE REGULATOR receiver
I6J64_RS04220	COG5002	protein histidine kinase activity
I6J64_RS04225	COG2205	protein histidine kinase activity
I6J64_RS04225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS04230	COG3279	Response regulator of the LytR AlgR family
I6J64_RS04235	COG3275	phosphorelay sensor kinase activity
I6J64_RS04250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J64_RS04260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J64_RS04280	COG0175	sulfate reduction
I6J64_RS04285	COG0529	Catalyzes the synthesis of activated sulfate
I6J64_RS04290	COG0471	metal ion transport
I6J64_RS04290	COG3273	potassium ion transport
I6J64_RS04305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J64_RS04335	COG0477	Major facilitator Superfamily
I6J64_RS04335	COG2814	Major facilitator Superfamily
I6J64_RS04340	COG2115	Belongs to the xylose isomerase family
I6J64_RS04355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J64_RS04375	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J64_RS04380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J64_RS04380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J64_RS04385	COG0343	queuine tRNA-ribosyltransferase activity
I6J64_RS04405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J64_RS04450	COG0285	dihydrofolate synthase activity
I6J64_RS04465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J64_RS04535	COG4974	Belongs to the 'phage' integrase family
I6J64_RS04545	COG1484	DNA-dependent DNA replication
I6J64_RS04575	COG3177	Filamentation induced by cAMP protein fic
I6J64_RS04580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J64_RS04595	COG1192	Involved in chromosome partitioning
I6J64_RS04655	COG1484	DNA-dependent DNA replication
I6J64_RS04665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J64_RS04675	COG1506	peptidase
I6J64_RS04675	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS04685	COG0039	L-malate dehydrogenase activity
I6J64_RS04690	COG1032	radical SAM domain protein
I6J64_RS04695	COG0251	oxidation-reduction process
I6J64_RS04700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J64_RS04725	COG3275	phosphorelay sensor kinase activity
I6J64_RS04740	COG0497	DNA recombination
I6J64_RS04755	COG1979	alcohol dehydrogenase
I6J64_RS04760	COG2176	DNA-directed DNA polymerase activity
I6J64_RS04775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J64_RS04780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J64_RS04800	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J64_RS04805	COG0022	dehydrogenase e1 component
I6J64_RS04810	COG0716	FMN binding
I6J64_RS04815	COG1846	Transcriptional regulator
I6J64_RS04865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J64_RS04870	COG2205	protein histidine kinase activity
I6J64_RS04870	COG0784	Response regulator, receiver
I6J64_RS04880	COG0126	phosphoglycerate kinase activity
I6J64_RS04890	COG0305	Participates in initiation and elongation during chromosome replication
I6J64_RS04905	COG3537	Alpha-1,2-mannosidase
I6J64_RS04910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J64_RS04920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J64_RS04925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J64_RS04930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J64_RS04935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J64_RS04945	COG4770	biotin carboxylase activity
I6J64_RS04950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J64_RS04955	COG0242	peptide deformylase activity
I6J64_RS04960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J64_RS04965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS04970	COG2885	chlorophyll binding
I6J64_RS04975	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J64_RS04980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS04995	COG0363	glucosamine-6-phosphate deaminase activity
I6J64_RS05000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J64_RS05005	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J64_RS05010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J64_RS05015	COG0471	metal ion transport
I6J64_RS05015	COG0490	domain, Protein
I6J64_RS05035	COG2204	response regulator
I6J64_RS05040	COG2311	Membrane
I6J64_RS05045	COG0784	Response regulator, receiver
I6J64_RS05045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS05045	COG2198	Histidine kinase
I6J64_RS05045	COG2205	protein histidine kinase activity
I6J64_RS05050	COG2194	sulfuric ester hydrolase activity
I6J64_RS05065	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J64_RS05090	COG2376	Dihydroxyacetone kinase
I6J64_RS05100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J64_RS05100	COG1333	cytochrome c biogenesis protein
I6J64_RS05130	COG2205	protein histidine kinase activity
I6J64_RS05130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS05135	COG0783	Belongs to the Dps family
I6J64_RS05145	COG0783	Belongs to the Dps family
I6J64_RS05155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J64_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
I6J64_RS05185	COG1757	Na H antiporter
I6J64_RS05200	COG1509	lysine 2,3-aminomutase activity
I6J64_RS05210	COG4771	TonB-dependent receptor
I6J64_RS05225	COG4206	TonB-dependent receptor
I6J64_RS05225	COG1629	transport
I6J64_RS05240	COG4206	TonB-dependent receptor
I6J64_RS05240	COG1629	transport
I6J64_RS05250	COG3189	MarR family transcriptional regulator
I6J64_RS05255	COG0588	phosphoglycerate mutase activity
I6J64_RS05270	COG1027	Aspartate ammonia-lyase
I6J64_RS05275	COG0133	tryptophan synthase activity
I6J64_RS05280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J64_RS05295	COG0134	indole-3-glycerol-phosphate synthase activity
I6J64_RS05300	COG0135	phosphoribosylanthranilate isomerase activity
I6J64_RS05305	COG0159	tryptophan synthase activity
I6J64_RS05310	COG1979	alcohol dehydrogenase
I6J64_RS05320	COG1139	Iron-sulfur cluster binding protein
I6J64_RS05325	COG0247	lactate metabolic process
I6J64_RS05335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J64_RS05340	COG0505	Belongs to the CarA family
I6J64_RS05360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J64_RS05370	COG1086	Polysaccharide biosynthesis protein
I6J64_RS05385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J64_RS05395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J64_RS05435	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J64_RS05485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS05500	COG4974	Belongs to the 'phage' integrase family
I6J64_RS05510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J64_RS05515	COG0167	dihydroorotate dehydrogenase activity
I6J64_RS05520	COG1846	Transcriptional regulator
I6J64_RS05525	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J64_RS05535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J64_RS05540	COG0791	NLP P60 protein
I6J64_RS05550	COG3275	phosphorelay sensor kinase activity
I6J64_RS05555	COG4948	Mandelate Racemase Muconate Lactonizing
I6J64_RS05565	COG1058	Belongs to the CinA family
I6J64_RS05565	COG1546	Belongs to the CinA family
I6J64_RS05570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J64_RS05585	COG0321	lipoyl(octanoyl) transferase activity
I6J64_RS05590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J64_RS05595	COG0318	PFAM AMP-dependent synthetase and ligase
I6J64_RS05605	COG1030	water channel activity
I6J64_RS05615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J64_RS05615	COG4651	solute:proton antiporter activity
I6J64_RS05620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6J64_RS05630	COG0706	membrane insertase activity
I6J64_RS05635	COG0504	CTP synthase activity
I6J64_RS05650	COG1245	4Fe-4S binding domain
I6J64_RS05650	COG2878	Part of a membrane complex involved in electron transport
I6J64_RS05655	COG4656	Part of a membrane complex involved in electron transport
I6J64_RS05660	COG4658	electron transport chain
I6J64_RS05665	COG4659	FMN binding
I6J64_RS05670	COG4660	Part of a membrane complex involved in electron transport
I6J64_RS05675	COG4657	Part of a membrane complex involved in electron transport
I6J64_RS05680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J64_RS05690	COG1011	Hydrolase
I6J64_RS05700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J64_RS05705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J64_RS05710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J64_RS05720	COG1629	transport
I6J64_RS05720	COG4206	TonB-dependent receptor
I6J64_RS05725	COG1629	transport
I6J64_RS05725	COG4206	TonB-dependent receptor
I6J64_RS05750	COG4771	TonB-dependent receptor
I6J64_RS05755	COG4771	TonB-dependent receptor
I6J64_RS05765	COG1119	ATPase activity
I6J64_RS05775	COG4771	TonB-dependent receptor
I6J64_RS05785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J64_RS05800	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
I6J64_RS05805	COG0653	protein targeting
I6J64_RS05810	COG0686	Belongs to the AlaDH PNT family
I6J64_RS05825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J64_RS05830	COG4942	peptidase
I6J64_RS05835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J64_RS05840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J64_RS05885	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J64_RS05890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J64_RS05895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J64_RS05895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J64_RS05920	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J64_RS05925	COG1960	acyl-CoA dehydrogenase activity
I6J64_RS05930	COG0534	Mate efflux family protein
I6J64_RS05940	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J64_RS05950	COG1288	antiporter activity
I6J64_RS05955	COG3118	belongs to the thioredoxin family
I6J64_RS05970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J64_RS05980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J64_RS05985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J64_RS05990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J64_RS06065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J64_RS06090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS06095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J64_RS06130	COG4974	Belongs to the 'phage' integrase family
I6J64_RS06135	COG4771	TonB-dependent receptor
I6J64_RS06140	COG0561	phosphatase activity
I6J64_RS06155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J64_RS06160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J64_RS06200	COG4771	TonB-dependent receptor
I6J64_RS06210	COG1649	PFAM Uncharacterised BCR, COG1649
I6J64_RS06220	COG0492	ferredoxin-NADP+ reductase activity
I6J64_RS06230	COG1674	ftsk spoiiie
I6J64_RS06235	COG0348	domain, Protein
I6J64_RS06240	COG0667	Aldo Keto reductase
I6J64_RS06245	COG4989	oxidoreductase activity
I6J64_RS06265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J64_RS06270	COG0702	epimerase
I6J64_RS06275	COG1629	transport
I6J64_RS06275	COG4206	TonB-dependent receptor
I6J64_RS06280	COG0039	L-malate dehydrogenase activity
I6J64_RS06305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J64_RS06320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS06330	COG1609	Transcriptional regulator
I6J64_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J64_RS06340	COG1312	Catalyzes the dehydration of D-mannonate
I6J64_RS06355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6J64_RS06380	COG2755	lipolytic protein G-D-S-L family
I6J64_RS06380	COG0657	acetylesterase activity
I6J64_RS06410	COG3119	arylsulfatase activity
I6J64_RS06420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J64_RS06425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J64_RS06435	COG1295	ribonuclease BN
I6J64_RS06440	COG0534	Mate efflux family protein
I6J64_RS06455	COG0484	heat shock protein binding
I6J64_RS06525	COG1309	transcriptional regulator
I6J64_RS06535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS06550	COG1028	Short-chain dehydrogenase reductase Sdr
I6J64_RS06555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J64_RS06560	COG0193	aminoacyl-tRNA hydrolase activity
I6J64_RS06565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J64_RS06590	COG0070	glutamate synthase
I6J64_RS06590	COG0067	glutamate synthase
I6J64_RS06590	COG0069	glutamate synthase activity
I6J64_RS06600	COG0367	asparagine synthase
I6J64_RS06610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J64_RS06615	COG0436	Aminotransferase
I6J64_RS06635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J64_RS06635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J64_RS06655	COG0673	inositol 2-dehydrogenase activity
I6J64_RS06665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J64_RS06670	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J64_RS06675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J64_RS06680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J64_RS06685	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J64_RS06705	COG1484	DNA-dependent DNA replication
I6J64_RS06715	COG1216	Glycosyl transferase, family 2
I6J64_RS06725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS06750	COG4974	Belongs to the 'phage' integrase family
I6J64_RS06785	COG2264	protein methyltransferase activity
I6J64_RS06810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J64_RS06815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J64_RS06835	COG0556	nucleotide-excision repair
I6J64_RS06855	COG1629	transport
I6J64_RS06875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS06885	COG3142	Participates in the control of copper homeostasis
I6J64_RS06890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J64_RS06895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J64_RS06905	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J64_RS06910	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J64_RS06915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J64_RS06920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J64_RS06925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J64_RS06930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J64_RS06940	COG0527	aspartate kinase activity
I6J64_RS06940	COG0460	homoserine dehydrogenase
I6J64_RS06945	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
I6J64_RS06950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J64_RS06965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J64_RS06995	COG4804	nuclease activity
I6J64_RS07040	COG0702	epimerase
I6J64_RS07045	COG4771	TonB-dependent receptor
I6J64_RS07060	COG0363	glucosamine-6-phosphate deaminase activity
I6J64_RS07075	COG0488	(ABC) transporter
I6J64_RS07080	COG1073	alpha beta
I6J64_RS07090	COG4771	TonB-dependent receptor
I6J64_RS07100	COG3250	beta-galactosidase activity
I6J64_RS07105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J64_RS07155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J64_RS07160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J64_RS07165	COG2217	Heavy metal translocating P-type atpase
I6J64_RS07180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J64_RS07185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J64_RS07190	COG0297	glycogen (starch) synthase activity
I6J64_RS07205	COG0297	glycogen (starch) synthase activity
I6J64_RS07215	COG0339	signal peptide processing
I6J64_RS07225	COG0793	Belongs to the peptidase S41A family
I6J64_RS07230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J64_RS07240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J64_RS07250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J64_RS07310	COG0300	oxidoreductase activity
I6J64_RS07320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J64_RS07330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J64_RS07335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J64_RS07360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J64_RS07380	COG0463	Glycosyl transferase, family 2
I6J64_RS07390	COG1971	Probably functions as a manganese efflux pump
I6J64_RS07395	COG0129	dihydroxy-acid dehydratase activity
I6J64_RS07400	COG1477	protein flavinylation
I6J64_RS07410	COG0424	maF-like protein
I6J64_RS07425	COG0778	Nitroreductase
I6J64_RS07435	COG0346	lactoylglutathione lyase activity
I6J64_RS07440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J64_RS07450	COG0511	ligase activity, forming carbon-carbon bonds
I6J64_RS07455	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J64_RS07465	COG1214	PFAM Peptidase M22, glycoprotease
I6J64_RS07470	COG1561	YicC-like family, N-terminal region
I6J64_RS07475	COG0194	GDP metabolic process
I6J64_RS07485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J64_RS07515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J64_RS07525	COG0166	Belongs to the GPI family
I6J64_RS07560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS07630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J64_RS07635	COG1086	Polysaccharide biosynthesis protein
I6J64_RS07665	COG4974	Belongs to the 'phage' integrase family
I6J64_RS07670	COG3040	lipid binding
I6J64_RS07675	COG1970	mechanosensitive ion channel activity
I6J64_RS07690	COG5002	protein histidine kinase activity
I6J64_RS07695	COG2204	response regulator
I6J64_RS07710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J64_RS07720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6J64_RS07725	COG3005	denitrification pathway
I6J64_RS07730	COG1360	Flagellar Motor Protein
I6J64_RS07745	COG0738	Major facilitator superfamily
I6J64_RS07750	COG3254	rhamnose metabolic process
I6J64_RS07755	COG1051	belongs to the nudix hydrolase family
I6J64_RS07760	COG0071	Belongs to the small heat shock protein (HSP20) family
I6J64_RS07775	COG2113	Glycine betaine
I6J64_RS07780	COG4176	ABC-type proline glycine betaine transport system permease component
I6J64_RS07790	COG2205	protein histidine kinase activity
I6J64_RS07795	COG0450	alkyl hydroperoxide reductase
I6J64_RS07810	COG1741	Belongs to the pirin family
I6J64_RS07815	COG0517	IMP dehydrogenase activity
I6J64_RS07815	COG0516	GMP reductase activity
I6J64_RS07825	COG0662	Cupin 2, conserved barrel domain protein
I6J64_RS07825	COG2207	Transcriptional regulator
I6J64_RS07830	COG4771	TonB-dependent receptor
I6J64_RS07855	COG1285	pathogenesis
I6J64_RS07860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J64_RS07870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J64_RS07880	COG0439	Biotin carboxylase
I6J64_RS07885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J64_RS07895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J64_RS07905	COG1438	arginine binding
I6J64_RS07915	COG0137	argininosuccinate synthase activity
I6J64_RS07920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J64_RS07925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J64_RS07960	COG4124	Belongs to the glycosyl hydrolase 26 family
I6J64_RS07965	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
I6J64_RS07970	COG2211	Major facilitator Superfamily
I6J64_RS07975	COG2942	2-epimerase
I6J64_RS07990	COG1252	NADH dehydrogenase
I6J64_RS08005	COG0318	PFAM AMP-dependent synthetase and ligase
I6J64_RS08020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J64_RS08045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J64_RS08060	COG1045	serine acetyltransferase
I6J64_RS08065	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS08065	COG0297	glycogen (starch) synthase activity
I6J64_RS08100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J64_RS08105	COG2244	polysaccharide biosynthetic process
I6J64_RS08125	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J64_RS08130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS08135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J64_RS08160	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J64_RS08165	COG4464	protein tyrosine phosphatase activity
I6J64_RS08180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS08215	COG2095	MarC family integral membrane protein
I6J64_RS08240	COG1640	4-alpha-glucanotransferase
I6J64_RS08250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J64_RS08260	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J64_RS08265	COG0359	binds to the 23S rRNA
I6J64_RS08270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J64_RS08275	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J64_RS08280	COG3119	arylsulfatase activity
I6J64_RS08285	COG3119	arylsulfatase activity
I6J64_RS08290	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J64_RS08295	COG1629	transport
I6J64_RS08305	COG1595	DNA-templated transcription, initiation
I6J64_RS08310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J64_RS08315	COG1187	pseudouridine synthase activity
I6J64_RS08325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J64_RS08375	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS08385	COG0616	signal peptide processing
I6J64_RS08390	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J64_RS08395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J64_RS08410	COG1484	DNA-dependent DNA replication
I6J64_RS08420	COG0527	aspartate kinase activity
I6J64_RS08430	COG2205	protein histidine kinase activity
I6J64_RS08440	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J64_RS08445	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J64_RS08450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J64_RS08475	COG3387	PFAM Glycoside hydrolase 15-related
I6J64_RS08480	COG0025	NhaP-type Na H and K H
I6J64_RS08485	COG0534	Mate efflux family protein
I6J64_RS08495	COG0584	glycerophosphoryl diester phosphodiesterase
I6J64_RS08500	COG3119	arylsulfatase activity
I6J64_RS08510	COG0702	epimerase
I6J64_RS08535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J64_RS08540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J64_RS08545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J64_RS08565	COG0697	spore germination
I6J64_RS08600	COG1484	DNA-dependent DNA replication
I6J64_RS08610	COG1342	Belongs to the UPF0251 family
I6J64_RS08825	COG4176	ABC-type proline glycine betaine transport system permease component
I6J64_RS08835	COG0659	secondary active sulfate transmembrane transporter activity
I6J64_RS08845	COG1285	pathogenesis
I6J64_RS08855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J64_RS08890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J64_RS08915	COG4771	TonB-dependent receptor
I6J64_RS08925	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J64_RS08935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS08950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6J64_RS08970	COG1090	epimerase
I6J64_RS08975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J64_RS09070	COG1484	DNA-dependent DNA replication
I6J64_RS09075	COG4974	Belongs to the 'phage' integrase family
I6J64_RS09085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J64_RS09090	COG1660	Displays ATPase and GTPase activities
I6J64_RS09095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J64_RS09105	COG2204	response regulator
I6J64_RS09115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6J64_RS09150	COG2198	Histidine kinase
I6J64_RS09150	COG2205	protein histidine kinase activity
I6J64_RS09150	COG0784	Response regulator, receiver
I6J64_RS09155	COG0525	valine-tRNA ligase activity
I6J64_RS09160	COG0564	pseudouridine synthase activity
I6J64_RS09170	COG3956	TIGRFAM MazG family protein
I6J64_RS09195	COG0459	protein refolding
I6J64_RS09200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J64_RS09210	COG0124	histidyl-tRNA synthetase
I6J64_RS09220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J64_RS09240	COG0482	sulfurtransferase activity
I6J64_RS09245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J64_RS09250	COG0586	Pfam SNARE associated Golgi protein
I6J64_RS09260	COG0366	Alpha amylase catalytic
I6J64_RS09265	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J64_RS09270	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J64_RS09290	COG2873	o-acetylhomoserine
I6J64_RS09305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J64_RS09310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J64_RS09325	COG3591	Belongs to the peptidase S1B family
I6J64_RS09355	COG2885	chlorophyll binding
I6J64_RS09355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J64_RS09400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J64_RS09405	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J64_RS09410	COG2373	Large extracellular alpha-helical protein
I6J64_RS09425	COG1703	isobutyryl-CoA mutase activity
I6J64_RS09440	COG0205	6-phosphofructokinase activity
I6J64_RS09445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J64_RS09450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J64_RS09470	COG0084	hydrolase, TatD family'
I6J64_RS09480	COG0811	peptide transport
I6J64_RS09505	COG1522	sequence-specific DNA binding
I6J64_RS09510	COG0017	Asparaginyl-tRNA synthetase
I6J64_RS09515	COG1187	pseudouridine synthase activity
I6J64_RS09550	COG0456	acetyltransferase
I6J64_RS09560	COG2502	aspartate--ammonia ligase
I6J64_RS09565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J64_RS09580	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS09580	COG1506	peptidase
I6J64_RS09600	COG3876	Protein conserved in bacteria
I6J64_RS09605	COG4771	TonB-dependent receptor
I6J64_RS09620	COG0534	Mate efflux family protein
I6J64_RS09625	COG1196	nuclear chromosome segregation
I6J64_RS09625	COG0739	heme binding
I6J64_RS09625	COG0741	lytic transglycosylase activity
I6J64_RS09630	COG3304	Inner membrane component domain
I6J64_RS09635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J64_RS09650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J64_RS09655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J64_RS09670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J64_RS09670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J64_RS09675	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J64_RS09680	COG2137	regulation of response to DNA damage stimulus
I6J64_RS09690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J64_RS09700	COG0165	Argininosuccinate lyase
I6J64_RS09735	COG0493	'glutamate synthase
I6J64_RS09745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J64_RS09750	COG1629	transport
I6J64_RS09765	COG0534	Mate efflux family protein
I6J64_RS09770	COG1120	ATPase activity
I6J64_RS09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J64_RS09780	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J64_RS09785	COG1629	transport
I6J64_RS09785	COG4206	TonB-dependent receptor
I6J64_RS09790	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J64_RS09830	COG2274	protein secretion by the type I secretion system
I6J64_RS09855	COG2205	protein histidine kinase activity
I6J64_RS09860	COG0745	RESPONSE REGULATOR receiver
I6J64_RS09865	COG1408	metallophosphoesterase
I6J64_RS09870	COG1408	metallophosphoesterase
I6J64_RS09875	COG0793	Belongs to the peptidase S41A family
I6J64_RS09880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J64_RS09905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J64_RS09910	COG0489	protein tyrosine kinase activity
I6J64_RS09920	COG2986	histidine ammonia-lyase
I6J64_RS09925	COG3404	Formiminotransferase-cyclodeaminase
I6J64_RS09930	COG1228	amidohydrolase
I6J64_RS09940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J64_RS09955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J64_RS09990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS10005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J64_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
I6J64_RS10025	COG3475	LICD family
I6J64_RS10040	COG3754	Rhamnan synthesis protein F
I6J64_RS10125	COG4974	Belongs to the 'phage' integrase family
I6J64_RS10130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J64_RS10165	COG0018	arginyl-trna synthetase
I6J64_RS10190	COG2208	phosphoserine phosphatase activity
I6J64_RS10190	COG2770	Histidine kinase
I6J64_RS10195	COG4191	Histidine kinase
I6J64_RS10195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS10200	COG4251	negative regulation of phosphorylation
I6J64_RS10205	COG3852	Histidine kinase
I6J64_RS10225	COG1940	carbohydrate kinase activity
I6J64_RS10245	COG1629	transport
I6J64_RS10245	COG4206	TonB-dependent receptor
I6J64_RS10250	COG1629	transport
I6J64_RS10250	COG4206	TonB-dependent receptor
I6J64_RS10255	COG0702	epimerase
I6J64_RS10280	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6J64_RS10285	COG1136	(ABC) transporter
I6J64_RS10290	COG1136	(ABC) transporter
I6J64_RS10290	COG0577	efflux transmembrane transporter activity
I6J64_RS10310	COG4771	TonB-dependent receptor
I6J64_RS10325	COG0363	glucosamine-6-phosphate deaminase activity
I6J64_RS10335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J64_RS10340	COG0673	inositol 2-dehydrogenase activity
I6J64_RS10345	COG1408	metallophosphoesterase
I6J64_RS10355	COG0673	inositol 2-dehydrogenase activity
I6J64_RS10365	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J64_RS10370	COG2172	sigma factor antagonist activity
I6J64_RS10390	COG1381	Involved in DNA repair and RecF pathway recombination
I6J64_RS10405	COG0268	Binds directly to 16S ribosomal RNA
I6J64_RS10415	COG0187	DNA topoisomerase II activity
I6J64_RS10420	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J64_RS10425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J64_RS10435	COG2166	iron-sulfur cluster assembly
I6J64_RS10440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J64_RS10450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J64_RS10455	COG3119	arylsulfatase activity
I6J64_RS10465	COG0366	Alpha amylase catalytic
I6J64_RS10470	COG0346	lactoylglutathione lyase activity
I6J64_RS10475	COG0719	Fe-S assembly protein
I6J64_RS10480	COG0396	ATPase activity
I6J64_RS10485	COG0719	Fe-S assembly protein
I6J64_RS10495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J64_RS10500	COG0195	Participates in both transcription termination and antitermination
I6J64_RS10500	COG2251	uridine kinase activity
I6J64_RS10505	COG0779	Required for maturation of 30S ribosomal subunits
I6J64_RS10605	COG4974	Belongs to the 'phage' integrase family
I6J64_RS10665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J64_RS10685	COG3292	Two component regulator propeller
I6J64_RS10685	COG0745	RESPONSE REGULATOR receiver
I6J64_RS10685	COG2205	protein histidine kinase activity
I6J64_RS10710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J64_RS10710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J64_RS10715	COG0436	Aminotransferase
I6J64_RS10720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J64_RS10725	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J64_RS10730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J64_RS10735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J64_RS10755	COG3118	belongs to the thioredoxin family
I6J64_RS10770	COG0784	Response regulator, receiver
I6J64_RS10770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS10770	COG2205	protein histidine kinase activity
I6J64_RS10770	COG2198	Histidine kinase
I6J64_RS10775	COG5000	phosphorelay sensor kinase activity
I6J64_RS10800	COG3292	Two component regulator propeller
I6J64_RS10800	COG0745	RESPONSE REGULATOR receiver
I6J64_RS10800	COG2205	protein histidine kinase activity
I6J64_RS10820	COG4191	Histidine kinase
I6J64_RS10845	COG0702	epimerase
I6J64_RS10850	COG1629	transport
I6J64_RS10850	COG4206	TonB-dependent receptor
I6J64_RS10890	COG4771	TonB-dependent receptor
I6J64_RS10910	COG0180	Tryptophanyl-tRNA synthetase
I6J64_RS10985	COG3307	-O-antigen
I6J64_RS11005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J64_RS11095	COG0110	maltose O-acetyltransferase activity
I6J64_RS11110	COG4771	TonB-dependent receptor
I6J64_RS11170	COG4771	TonB-dependent receptor
I6J64_RS11180	COG3634	alkyl hydroperoxide reductase activity
I6J64_RS11190	COG0148	phosphopyruvate hydratase activity
I6J64_RS11200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J64_RS11210	COG0745	RESPONSE REGULATOR receiver
I6J64_RS11210	COG2205	protein histidine kinase activity
I6J64_RS11210	COG3292	Two component regulator propeller
I6J64_RS11215	COG4771	TonB-dependent receptor
I6J64_RS11225	COG3537	Alpha-1,2-mannosidase
I6J64_RS11240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J64_RS11245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J64_RS11250	COG0009	L-threonylcarbamoyladenylate synthase
I6J64_RS11255	COG3250	beta-galactosidase activity
I6J64_RS11265	COG1629	transport
I6J64_RS11275	COG1162	GTPase activity
I6J64_RS11280	COG0233	cytoplasmic translational termination
I6J64_RS11295	COG1621	beta-fructofuranosidase activity
I6J64_RS11300	COG0745	RESPONSE REGULATOR receiver
I6J64_RS11300	COG2205	protein histidine kinase activity
I6J64_RS11300	COG3292	Two component regulator propeller
I6J64_RS11305	COG0528	UMP kinase activity
I6J64_RS11310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J64_RS11315	COG0280	phosphate acetyltransferase
I6J64_RS11320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J64_RS11325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J64_RS11330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J64_RS11345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J64_RS11355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J64_RS11355	COG4651	solute:proton antiporter activity
I6J64_RS11365	COG0628	permease
I6J64_RS11375	COG3279	Response regulator of the LytR AlgR family
I6J64_RS11380	COG2972	Histidine kinase
I6J64_RS11385	COG0577	efflux transmembrane transporter activity
I6J64_RS11385	COG1136	(ABC) transporter
I6J64_RS11390	COG1136	(ABC) transporter
I6J64_RS11395	COG1566	PFAM secretion protein HlyD family protein
I6J64_RS11405	COG2059	Chromate
I6J64_RS11415	COG0793	Belongs to the peptidase S41A family
I6J64_RS11420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J64_RS11440	COG0557	exoribonuclease II activity
I6J64_RS11450	COG0802	atpase or kinase
I6J64_RS11455	COG2204	response regulator
I6J64_RS11475	COG4206	TonB-dependent receptor
I6J64_RS11475	COG1629	transport
I6J64_RS11480	COG0561	phosphatase activity
I6J64_RS11500	COG3263	regulation of cellular component size
I6J64_RS11515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J64_RS11530	COG2096	Adenosyltransferase
I6J64_RS11545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J64_RS11570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J64_RS11585	COG2205	protein histidine kinase activity
I6J64_RS11585	COG0784	Response regulator, receiver
I6J64_RS11585	COG2198	Histidine kinase
I6J64_RS11610	COG4974	Belongs to the 'phage' integrase family
I6J64_RS11615	COG4804	nuclease activity
I6J64_RS11625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J64_RS11645	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J64_RS11650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J64_RS11665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J64_RS11670	COG4974	Belongs to the 'phage' integrase family
I6J64_RS11685	COG4771	TonB-dependent receptor
I6J64_RS11700	COG2814	Major facilitator Superfamily
I6J64_RS11715	COG2140	Oxalate decarboxylase
I6J64_RS11720	COG2207	Transcriptional regulator
I6J64_RS11720	COG0662	Cupin 2, conserved barrel domain protein
I6J64_RS11730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J64_RS11745	COG4771	TonB-dependent receptor
I6J64_RS11760	COG1649	PFAM Uncharacterised BCR, COG1649
I6J64_RS11830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J64_RS11845	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I6J64_RS11850	COG4974	Belongs to the 'phage' integrase family
I6J64_RS11965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS11975	COG3206	protein involved in exopolysaccharide biosynthesis
I6J64_RS11975	COG0489	protein tyrosine kinase activity
I6J64_RS11990	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS11995	COG2244	polysaccharide biosynthetic process
I6J64_RS12005	COG1442	glycosyl transferase family 8
I6J64_RS12010	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS12020	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS12030	COG0463	Glycosyl transferase, family 2
I6J64_RS12040	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS12045	COG0662	Cupin 2, conserved barrel domain protein
I6J64_RS12045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J64_RS12080	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J64_RS12095	COG4206	TonB-dependent receptor
I6J64_RS12095	COG1629	transport
I6J64_RS12125	COG1053	succinate dehydrogenase
I6J64_RS12135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J64_RS12145	COG2205	protein histidine kinase activity
I6J64_RS12145	COG0784	Response regulator, receiver
I6J64_RS12145	COG2198	Histidine kinase
I6J64_RS12155	COG3279	Response regulator of the LytR AlgR family
I6J64_RS12165	COG0423	glycine-tRNA ligase activity
I6J64_RS12170	COG0673	inositol 2-dehydrogenase activity
I6J64_RS12205	COG0758	DNA mediated transformation
I6J64_RS12205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J64_RS12215	COG0826	peptidase U32
I6J64_RS12245	COG1904	glucuronate isomerase
I6J64_RS12250	COG4771	TonB-dependent receptor
I6J64_RS12265	COG1785	Belongs to the alkaline phosphatase family
I6J64_RS12295	COG0756	dUTP diphosphatase activity
I6J64_RS12300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J64_RS12305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J64_RS12310	COG0509	glycine decarboxylation via glycine cleavage system
I6J64_RS12335	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS12400	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J64_RS12410	COG1228	amidohydrolase
I6J64_RS12420	COG0024	Methionine aminopeptidase
I6J64_RS12430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J64_RS12440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J64_RS12455	COG3537	Alpha-1,2-mannosidase
I6J64_RS12470	COG3537	Alpha-1,2-mannosidase
I6J64_RS12475	COG3250	beta-galactosidase activity
I6J64_RS12505	COG4771	TonB-dependent receptor
I6J64_RS12515	COG1595	DNA-templated transcription, initiation
I6J64_RS12525	COG4948	Mandelate Racemase Muconate Lactonizing
I6J64_RS12540	COG0702	epimerase
I6J64_RS12545	COG1629	transport
I6J64_RS12545	COG4206	TonB-dependent receptor
I6J64_RS12560	COG2311	Membrane
I6J64_RS12570	COG3250	beta-galactosidase activity
I6J64_RS12575	COG3250	beta-galactosidase activity
I6J64_RS12595	COG4771	TonB-dependent receptor
I6J64_RS12605	COG1595	DNA-templated transcription, initiation
I6J64_RS12625	COG1629	transport
I6J64_RS12625	COG4206	TonB-dependent receptor
I6J64_RS12645	COG2837	iron assimilation
I6J64_RS12650	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J64_RS12655	COG3250	beta-galactosidase activity
I6J64_RS12660	COG1501	Belongs to the glycosyl hydrolase 31 family
I6J64_RS12665	COG3292	Two component regulator propeller
I6J64_RS12665	COG2205	protein histidine kinase activity
I6J64_RS12665	COG0745	RESPONSE REGULATOR receiver
I6J64_RS12670	COG0196	riboflavin kinase activity
I6J64_RS12675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J64_RS12700	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS12700	COG1506	peptidase
I6J64_RS12705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J64_RS12705	COG0116	Belongs to the methyltransferase superfamily
I6J64_RS12710	COG1045	serine acetyltransferase
I6J64_RS12755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS12765	COG1121	(ABC) transporter
I6J64_RS12780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J64_RS12805	COG0612	Peptidase, M16
I6J64_RS12810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J64_RS12860	COG0702	epimerase
I6J64_RS12865	COG4771	TonB-dependent receptor
I6J64_RS12880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J64_RS12890	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J64_RS12895	COG0594	ribonuclease P activity
I6J64_RS12990	COG0534	Mate efflux family protein
I6J64_RS12995	COG0702	epimerase
I6J64_RS13010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J64_RS13015	COG1592	Rubrerythrin
I6J64_RS13020	COG0659	secondary active sulfate transmembrane transporter activity
I6J64_RS13025	COG5183	chlorophyll binding
I6J64_RS13025	COG2133	pyrroloquinoline quinone binding
I6J64_RS13065	COG3250	beta-galactosidase activity
I6J64_RS13070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J64_RS13070	COG0731	radical SAM domain protein
I6J64_RS13085	COG3645	SOS response
I6J64_RS13100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J64_RS13120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J64_RS13130	COG0495	leucyl-tRNA aminoacylation
I6J64_RS13175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J64_RS13180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J64_RS13220	COG2207	Transcriptional regulator
I6J64_RS13225	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS13230	COG0012	GTP binding
I6J64_RS13295	COG2814	Major facilitator Superfamily
I6J64_RS13300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J64_RS13300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J64_RS13305	COG0142	geranyltranstransferase activity
I6J64_RS13315	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J64_RS13320	COG1490	D-aminoacyl-tRNA deacylase activity
I6J64_RS13325	COG0322	excinuclease ABC activity
I6J64_RS13330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J64_RS13335	COG0445	tRNA wobble uridine modification
I6J64_RS13355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J64_RS13360	COG2715	membrane protein required for spore maturation
I6J64_RS13365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J64_RS13405	COG0156	8-amino-7-oxononanoate synthase activity
I6J64_RS13415	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6J64_RS13420	COG2755	lipolytic protein G-D-S-L family
I6J64_RS13420	COG0657	acetylesterase activity
I6J64_RS13425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J64_RS13435	COG0702	epimerase
I6J64_RS13440	COG4771	TonB-dependent receptor
I6J64_RS13455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J64_RS13460	COG1940	carbohydrate kinase activity
I6J64_RS13480	COG0535	radical SAM domain protein
I6J64_RS13500	COG1216	Glycosyl transferase, family 2
I6J64_RS13515	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS13520	COG0297	glycogen (starch) synthase activity
I6J64_RS13580	COG2255	four-way junction helicase activity
I6J64_RS13590	COG2205	protein histidine kinase activity
I6J64_RS13590	COG2202	Pas domain
I6J64_RS13600	COG3591	Belongs to the peptidase S1B family
I6J64_RS13615	COG1538	Outer membrane efflux protein
I6J64_RS13655	COG2365	Tyrosine phosphatase family
I6J64_RS13660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J64_RS13665	COG0517	IMP dehydrogenase activity
I6J64_RS13665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J64_RS13680	COG0612	Peptidase, M16
I6J64_RS13690	COG1115	amino acid carrier protein
I6J64_RS13695	COG4206	TonB-dependent receptor
I6J64_RS13695	COG1629	transport
I6J64_RS13715	COG0733	neurotransmitter:sodium symporter activity
I6J64_RS13755	COG1136	(ABC) transporter
I6J64_RS13760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J64_RS13765	COG4948	Mandelate Racemase Muconate Lactonizing
I6J64_RS13775	COG1940	carbohydrate kinase activity
I6J64_RS13780	COG0363	glucosamine-6-phosphate deaminase activity
I6J64_RS13795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J64_RS13800	COG1629	transport
I6J64_RS13800	COG4206	TonB-dependent receptor
I6J64_RS13810	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J64_RS13900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J64_RS13905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J64_RS13920	COG0681	Belongs to the peptidase S26 family
I6J64_RS13925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J64_RS13980	COG0215	cysteine-tRNA ligase activity
I6J64_RS14000	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J64_RS14015	COG0205	6-phosphofructokinase activity
I6J64_RS14025	COG0571	ribonuclease III activity
I6J64_RS14030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J64_RS14035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J64_RS14040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J64_RS14045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J64_RS14065	COG0745	RESPONSE REGULATOR receiver
I6J64_RS14100	COG3341	Caulimovirus viroplasmin
I6J64_RS14100	COG0328	RNA-DNA hybrid ribonuclease activity
I6J64_RS14125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J64_RS14130	COG0686	Belongs to the AlaDH PNT family
I6J64_RS14135	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J64_RS14135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J64_RS14140	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J64_RS14145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J64_RS14155	COG0606	chelatase, subunit chli
I6J64_RS14160	COG1917	Cupin 2, conserved barrel domain protein
I6J64_RS14160	COG4977	sequence-specific DNA binding
I6J64_RS14205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J64_RS14205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J64_RS14220	COG2244	polysaccharide biosynthetic process
I6J64_RS14255	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS14280	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS14285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J64_RS14295	COG1917	Cupin 2, conserved barrel domain protein
I6J64_RS14295	COG2207	Transcriptional regulator
I6J64_RS14300	COG0318	PFAM AMP-dependent synthetase and ligase
I6J64_RS14310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J64_RS14315	COG1217	gtp-binding protein TYPA
I6J64_RS14335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J64_RS14335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J64_RS14355	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J64_RS14360	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J64_RS14370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J64_RS14385	COG1695	Transcriptional regulator
I6J64_RS14390	COG1022	Amp-dependent synthetase and ligase
I6J64_RS14415	COG0745	RESPONSE REGULATOR receiver
I6J64_RS14415	COG2205	protein histidine kinase activity
I6J64_RS14415	COG3292	Two component regulator propeller
I6J64_RS14430	COG0366	Alpha amylase catalytic
I6J64_RS14435	COG4771	TonB-dependent receptor
I6J64_RS14445	COG0366	Alpha amylase catalytic
I6J64_RS14455	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J64_RS14455	COG1082	Xylose isomerase domain protein TIM barrel
I6J64_RS14500	COG0393	Putative heavy-metal-binding
I6J64_RS14525	COG2431	L-lysine efflux transmembrane transporter activity
I6J64_RS14535	COG3275	phosphorelay sensor kinase activity
I6J64_RS14560	COG0793	Belongs to the peptidase S41A family
I6J64_RS14560	COG4946	Tricorn protease homolog
I6J64_RS14575	COG1757	Na H antiporter
I6J64_RS14580	COG1757	Na H antiporter
I6J64_RS14610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J64_RS14630	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J64_RS14635	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J64_RS14640	COG1522	sequence-specific DNA binding
I6J64_RS14650	COG1570	exodeoxyribonuclease VII activity
I6J64_RS14665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J64_RS14670	COG0739	heme binding
I6J64_RS14685	COG0149	triose-phosphate isomerase activity
I6J64_RS14695	COG0302	gtp cyclohydrolase
I6J64_RS14720	COG3279	Response regulator of the LytR AlgR family
I6J64_RS14725	COG2382	esterase
I6J64_RS14735	COG1196	nuclear chromosome segregation
I6J64_RS14740	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J64_RS14775	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J64_RS14780	COG0515	serine threonine protein kinase
I6J64_RS14780	COG2815	serine threonine protein kinase
I6J64_RS14785	COG0564	pseudouridine synthase activity
I6J64_RS14790	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J64_RS14830	COG0483	inositol monophosphate 1-phosphatase activity
I6J64_RS14845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J64_RS14850	COG0569	domain protein
I6J64_RS14855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J64_RS14865	COG0632	four-way junction helicase activity
I6J64_RS14875	COG4772	TonB-dependent receptor
I6J64_RS14885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J64_RS14910	COG1234	tRNA 3'-trailer cleavage
I6J64_RS14925	COG1271	oxidase subunit
I6J64_RS14950	COG0673	inositol 2-dehydrogenase activity
I6J64_RS14990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J64_RS14995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6J64_RS15015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6J64_RS15045	COG0673	inositol 2-dehydrogenase activity
I6J64_RS15055	COG0776	regulation of translation
I6J64_RS15065	COG0546	phosphoglycolate phosphatase activity
I6J64_RS15090	COG2202	Pas domain
I6J64_RS15090	COG2205	protein histidine kinase activity
I6J64_RS15100	COG1595	DNA-templated transcription, initiation
I6J64_RS15115	COG1280	lysine exporter protein (LysE YggA)
I6J64_RS15120	COG3119	arylsulfatase activity
I6J64_RS15125	COG3119	arylsulfatase activity
I6J64_RS15145	COG1730	sister chromatid segregation
I6J64_RS15195	COG0167	dihydroorotate dehydrogenase activity
I6J64_RS15205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J64_RS15220	COG2003	Belongs to the UPF0758 family
I6J64_RS15225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J64_RS15230	COG1346	cytolysis
I6J64_RS15240	COG2239	Acts as a magnesium transporter
I6J64_RS15245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J64_RS15255	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J64_RS15275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J64_RS15280	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J64_RS15295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J64_RS15300	COG2205	protein histidine kinase activity
I6J64_RS15300	COG5002	protein histidine kinase activity
I6J64_RS15300	COG0784	Response regulator, receiver
I6J64_RS15310	COG1074	ATP-dependent DNA helicase activity
I6J64_RS15315	COG0688	phosphatidylethanolamine metabolic process
I6J64_RS15340	COG0792	nuclease activity
I6J64_RS15370	COG1192	Involved in chromosome partitioning
I6J64_RS15375	COG1475	DNA binding
I6J64_RS15385	COG3942	CHAP domain
I6J64_RS15385	COG1388	LysM domain
I6J64_RS15390	COG3275	phosphorelay sensor kinase activity
I6J64_RS15395	COG3279	Response regulator of the LytR AlgR family
I6J64_RS15410	COG1522	sequence-specific DNA binding
I6J64_RS15420	COG4771	TonB-dependent receptor
I6J64_RS15445	COG0739	heme binding
I6J64_RS15450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J64_RS15455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J64_RS15495	COG4974	Belongs to the 'phage' integrase family
I6J64_RS15505	COG1373	ATPase (AAA superfamily
I6J64_RS15525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J64_RS15525	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J64_RS15535	COG4771	TonB-dependent receptor
I6J64_RS15540	COG1506	peptidase
I6J64_RS15545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6J64_RS15555	COG4771	TonB-dependent receptor
I6J64_RS15585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J64_RS15600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J64_RS15605	COG1477	protein flavinylation
I6J64_RS15620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J64_RS15645	COG0742	ribosomal rna small subunit methyltransferase
I6J64_RS15650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J64_RS15680	COG0275	rRNA processing
I6J64_RS15690	COG0768	penicillin binding
I6J64_RS15695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J64_RS15700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS15705	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J64_RS15710	COG0772	Belongs to the SEDS family
I6J64_RS15715	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J64_RS15720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J64_RS15725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J64_RS15735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J64_RS15740	COG1610	YqeY-like protein
I6J64_RS15745	COG1966	Carbon starvation protein
I6J64_RS15775	COG4771	TonB-dependent receptor
I6J64_RS15790	COG0673	inositol 2-dehydrogenase activity
I6J64_RS15805	COG4771	TonB-dependent receptor
I6J64_RS15810	COG0561	phosphatase activity
I6J64_RS15965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J64_RS15970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J64_RS15975	COG1160	GTP binding
I6J64_RS16010	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J64_RS16030	COG1132	(ABC) transporter
I6J64_RS16050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J64_RS16055	COG0581	inorganic phosphate transmembrane transporter activity
I6J64_RS16060	COG0573	inorganic phosphate transmembrane transporter activity
I6J64_RS16065	COG0427	acetyl-CoA hydrolase
I6J64_RS16075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J64_RS16085	COG0702	epimerase
I6J64_RS16090	COG4771	TonB-dependent receptor
I6J64_RS16105	COG2177	Part of the ABC transporter FtsEX involved in
I6J64_RS16115	COG1968	undecaprenyl-diphosphatase activity
I6J64_RS16120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J64_RS16125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J64_RS16130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J64_RS16130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J64_RS16140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J64_RS16145	COG1127	ABC transporter
I6J64_RS16150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J64_RS16160	COG1137	ATPase activity
I6J64_RS16170	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J64_RS16175	COG0740	serine-type endopeptidase activity
I6J64_RS16180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J64_RS16185	COG0514	ATP-dependent DNA helicase (RecQ)
I6J64_RS16190	COG0517	IMP dehydrogenase activity
I6J64_RS16190	COG0516	GMP reductase activity
I6J64_RS16195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J64_RS16220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J64_RS16235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J64_RS16240	COG0049	tRNA binding
I6J64_RS16245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J64_RS16250	COG0051	transcription antitermination factor activity, RNA binding
I6J64_RS16255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J64_RS16260	COG0088	Forms part of the polypeptide exit tunnel
I6J64_RS16265	COG0089	rRNA binding
I6J64_RS16270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J64_RS16275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J64_RS16280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J64_RS16285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J64_RS16290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J64_RS16295	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J64_RS16300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J64_RS16305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J64_RS16310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J64_RS16315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J64_RS16320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J64_RS16325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J64_RS16330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J64_RS16335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J64_RS16340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J64_RS16345	COG1841	ribosomal large subunit assembly
I6J64_RS16350	COG0200	Binds to the 23S rRNA
I6J64_RS16355	COG0201	protein transport
I6J64_RS16365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J64_RS16370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J64_RS16375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J64_RS16380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J64_RS16385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J64_RS16390	COG0202	RNA polymerase activity
I6J64_RS16395	COG0203	ribosomal protein L17
I6J64_RS16405	COG0148	phosphopyruvate hydratase activity
I6J64_RS16460	COG0335	large ribosomal subunit rRNA binding
I6J64_RS16480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J64_RS16495	COG4771	TonB-dependent receptor
I6J64_RS16500	COG0702	epimerase
I6J64_RS16505	COG3537	Alpha-1,2-mannosidase
I6J64_RS16530	COG3279	Response regulator of the LytR AlgR family
I6J64_RS16555	COG4771	TonB-dependent receptor
I6J64_RS16560	COG0702	epimerase
I6J64_RS16565	COG3119	arylsulfatase activity
I6J64_RS16570	COG3119	arylsulfatase activity
I6J64_RS16575	COG3119	arylsulfatase activity
I6J64_RS16590	COG4771	TonB-dependent receptor
I6J64_RS16595	COG0702	epimerase
I6J64_RS16600	COG3119	arylsulfatase activity
I6J64_RS16620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J64_RS16660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J64_RS16665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J64_RS16665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J64_RS16680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J64_RS16685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J64_RS16720	COG1480	7TM receptor with intracellular HD hydrolase
I6J64_RS16725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J64_RS16750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J64_RS16755	COG0006	proline dipeptidase activity
I6J64_RS16770	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J64_RS16775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J64_RS16780	COG4974	Belongs to the 'phage' integrase family
I6J64_RS16785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J64_RS16810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J64_RS16825	COG0250	Participates in transcription elongation, termination and antitermination
I6J64_RS16830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J64_RS16835	COG0081	regulation of translation
I6J64_RS16840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J64_RS16845	COG0222	ribosome binding
I6J64_RS16850	COG0085	RNA polymerase activity
I6J64_RS16855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J64_RS16865	COG2207	Transcriptional regulator
I6J64_RS16880	COG5002	protein histidine kinase activity
I6J64_RS16880	COG3850	Histidine kinase
I6J64_RS16885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J64_RS16890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J64_RS16895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J64_RS16915	COG1012	belongs to the aldehyde dehydrogenase family
I6J64_RS16925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J64_RS16945	COG0823	Involved in the tonB-independent uptake of proteins
I6J64_RS16945	COG1506	peptidase
I6J64_RS16960	COG4974	Belongs to the 'phage' integrase family
I6J64_RS17045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J64_RS17055	COG0489	protein tyrosine kinase activity
I6J64_RS17055	COG3206	protein involved in exopolysaccharide biosynthesis
I6J64_RS17060	COG4464	protein tyrosine phosphatase activity
I6J64_RS17075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J64_RS17080	COG2244	polysaccharide biosynthetic process
I6J64_RS17100	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS17105	COG0463	Glycosyl transferase, family 2
I6J64_RS17115	COG1216	Glycosyl transferase, family 2
I6J64_RS17130	COG0438	transferase activity, transferring glycosyl groups
I6J64_RS17140	COG0110	maltose O-acetyltransferase activity
I6J64_RS17150	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6J64_RS17155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J64_RS17160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6J64_RS17160	COG0662	Cupin 2, conserved barrel domain protein
I6J64_RS17175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J64_RS17195	COG1242	4 iron, 4 sulfur cluster binding
I6J64_RS17205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J64_RS17220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6J64_RS17240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J64_RS17250	COG3537	Alpha-1,2-mannosidase
I6J64_RS17255	COG0534	Mate efflux family protein
I6J64_RS17265	COG0564	pseudouridine synthase activity
I6J64_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
I6J64_RS17300	COG1090	epimerase
I6J64_RS17315	COG1063	alcohol dehydrogenase
I6J64_RS17340	COG0693	protein deglycase activity
I6J64_RS17465	COG1484	DNA-dependent DNA replication
I6J64_RS17495	COG4974	Belongs to the 'phage' integrase family
I6J64_RS17505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J64_RS17525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J64_RS17530	COG0813	purine-nucleoside phosphorylase activity
I6J64_RS17535	COG4864	UPF0365 protein
I6J64_RS17550	COG0037	tRNA processing
I6J64_RS17560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J64_RS17575	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J64_RS17580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J64_RS17580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6J64_RS17585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J64_RS17590	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J64_RS17595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J64_RS17600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J64_RS17605	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J64_RS17615	COG0295	cytidine deaminase activity
I6J64_RS17620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J64_RS17625	COG0739	heme binding
I6J64_RS17630	COG0259	pyridoxamine-phosphate oxidase activity
I6J64_RS17645	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J64_RS17670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J64_RS17675	COG1012	belongs to the aldehyde dehydrogenase family
I6J64_RS17690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J64_RS17695	COG2076	Multidrug Resistance protein
I6J64_RS17700	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J64_RS17705	COG1047	Peptidyl-prolyl cis-trans
I6J64_RS17710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J64_RS17715	COG3119	arylsulfatase activity
I6J64_RS17720	COG3119	arylsulfatase activity
I6J64_RS17730	COG4206	TonB-dependent receptor
I6J64_RS17730	COG1629	transport
I6J64_RS17745	COG0129	dihydroxy-acid dehydratase activity
I6J64_RS17750	COG0028	Belongs to the TPP enzyme family
I6J64_RS17765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J64_RS17795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J64_RS17800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J64_RS17805	COG0066	3-isopropylmalate dehydratase activity
I6J64_RS17830	COG0668	transmembrane transport
I6J64_RS17850	COG0617	tRNA 3'-terminal CCA addition
I6J64_RS17850	COG0517	IMP dehydrogenase activity
I6J64_RS17850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J64_RS17865	COG0673	inositol 2-dehydrogenase activity
I6J64_RS17920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J64_RS17920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J64_RS17945	COG0488	(ABC) transporter
I6J64_RS17950	COG2814	Major facilitator Superfamily
I6J64_RS17980	COG0436	Aminotransferase
I6J64_RS17985	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J64_RS17995	COG1215	transferase activity, transferring glycosyl groups
I6J64_RS18000	COG0019	diaminopimelate decarboxylase activity
I6J64_RS18005	COG0527	aspartate kinase activity
I6J64_RS18010	COG2884	Cell division ATP-binding protein ftsE
I6J64_RS18015	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J64_RS18015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J64_RS18020	COG0107	imidazoleglycerol-phosphate synthase activity
I6J64_RS18025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J64_RS18050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J64_RS18070	COG2382	esterase
I6J64_RS18080	COG0058	SHG alpha-glucan phosphorylase activity
I6J64_RS18100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J64_RS18105	COG2211	Major facilitator Superfamily
I6J64_RS18110	COG2198	Histidine kinase
I6J64_RS18110	COG2205	protein histidine kinase activity
I6J64_RS18110	COG0784	Response regulator, receiver
I6J64_RS18120	COG0443	Heat shock 70 kDa protein
I6J64_RS18125	COG1530	ribonuclease E activity
I6J64_RS18130	COG0776	regulation of translation
I6J64_RS18140	COG0629	single-stranded DNA binding
I6J64_RS18145	COG4535	Mg2 and Co2 transporter CorC
I6J64_RS18160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J64_RS18165	COG2226	methyltransferase
I6J64_RS18170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J64_RS18175	COG1702	phosphate starvation-inducible protein PhoH
I6J64_RS18185	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J64_RS18210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J64_RS18220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6J64_RS18225	COG3250	beta-galactosidase activity
I6J64_RS18245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J64_RS18250	COG0577	efflux transmembrane transporter activity
I6J64_RS18265	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6J64_RS18270	COG0577	efflux transmembrane transporter activity
I6J64_RS18280	COG1136	(ABC) transporter
I6J64_RS18310	COG0577	efflux transmembrane transporter activity
I6J64_RS18310	COG1136	(ABC) transporter
I6J64_RS18340	COG2972	Histidine kinase
I6J64_RS18345	COG3279	Response regulator of the LytR AlgR family
I6J64_RS18355	COG2204	response regulator
I6J64_RS18360	COG3852	Histidine kinase
I6J64_RS18375	COG0254	rRNA binding
I6J64_RS18380	COG0191	fructose-bisphosphate aldolase activity
I6J64_RS18395	COG2814	Major facilitator Superfamily
I6J64_RS18400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J64_RS18405	COG2315	Protein conserved in bacteria
I6J64_RS18415	COG2985	domain, Protein
I6J64_RS18415	COG0490	domain, Protein
I6J64_RS18420	COG0101	tRNA pseudouridine synthase activity
I6J64_RS18445	COG5002	protein histidine kinase activity
I6J64_RS18450	COG0745	RESPONSE REGULATOR receiver
I6J64_RS18460	COG1595	DNA-templated transcription, initiation
I6J64_RS18485	COG2207	Transcriptional regulator
I6J64_RS18485	COG4753	response regulator
I6J64_RS18490	COG3059	membrane
I6J64_RS18500	COG1629	transport
I6J64_RS18510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J64_RS18515	COG0500	methyltransferase
I6J64_RS18520	COG2830	Protein of unknown function (DUF452)
I6J64_RS18535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J64_RS18565	COG4206	TonB-dependent receptor
I6J64_RS18565	COG1629	transport
I6J64_RS18590	COG0673	inositol 2-dehydrogenase activity
I6J64_RS18600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J64_RS18600	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J64_RS18605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J64_RS18610	COG0563	adenylate kinase activity
I6J64_RS18615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J64_RS18620	COG1496	oxidoreductase activity
I6J64_RS18645	COG1418	mRNA catabolic process
I6J64_RS18650	COG3119	arylsulfatase activity
I6J64_RS18655	COG0488	(ABC) transporter
I6J64_RS18675	COG0138	bifunctional purine biosynthesis protein purh
I6J64_RS18680	COG1077	Cell shape determining protein MreB Mrl
I6J64_RS18685	COG1792	Involved in formation and maintenance of cell shape
I6J64_RS18700	COG0772	Belongs to the SEDS family
I6J64_RS18710	COG1774	PSP1 C-terminal conserved region
I6J64_RS18715	COG0156	8-amino-7-oxononanoate synthase activity
I6J64_RS18720	COG1597	lipid kinase activity
I6J64_RS18725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J64_RS18730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J64_RS18740	COG0673	inositol 2-dehydrogenase activity
I6J64_RS18750	COG0673	inositol 2-dehydrogenase activity
I6J64_RS18775	COG1882	Formate acetyltransferase
I6J64_RS18780	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J64_RS18810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J64_RS18835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J64_RS18840	COG0799	negative regulation of ribosome biogenesis
I6J64_RS18860	COG4152	abc transporter atp-binding protein
I6J64_RS18865	COG0358	DNA primase activity
I6J64_RS18880	COG5039	Polysaccharide pyruvyl transferase
I6J64_RS18885	COG1216	Glycosyl transferase, family 2
I6J64_RS18905	COG3475	LICD family
I6J64_RS18915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J64_RS18920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS18935	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J64_RS18955	COG0519	Catalyzes the synthesis of GMP from XMP
I6J64_RS18955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J64_RS18960	COG0519	Catalyzes the synthesis of GMP from XMP
I6J64_RS18975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J64_RS18990	COG0501	Belongs to the peptidase M48B family
I6J64_RS19000	COG0583	DNA-binding transcription factor activity
I6J64_RS19005	COG2855	membrane
I6J64_RS19010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J64_RS19015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J64_RS19020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J64_RS19025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J64_RS19030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J64_RS19035	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6J64_RS19040	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6J64_RS19055	COG0409	Hydrogenase expression formation protein
I6J64_RS19070	COG0375	protein maturation
I6J64_RS19095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J64_RS19105	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J64_RS19105	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J64_RS19105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J64_RS19105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J64_RS19125	COG0737	Belongs to the 5'-nucleotidase family
I6J64_RS19180	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J64_RS19205	COG0534	Mate efflux family protein
I6J64_RS19215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J64_RS19225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J64_RS19245	COG0667	Aldo Keto reductase
I6J64_RS19255	COG0288	reversible hydration of carbon dioxide
I6J64_RS19265	COG2234	aminopeptidase activity
I6J64_RS19270	COG1629	transport
I6J64_RS19270	COG4206	TonB-dependent receptor
I6J64_RS19285	COG4206	TonB-dependent receptor
I6J64_RS19285	COG1629	transport
I6J64_RS19300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J64_RS19305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J64_RS19310	COG0805	protein transport
I6J64_RS19320	COG3537	Alpha-1,2-mannosidase
I6J64_RS19330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J64_RS19335	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6J64_RS19355	COG2985	domain, Protein
I6J64_RS19355	COG0569	domain protein
I6J64_RS19370	COG0514	ATP-dependent DNA helicase (RecQ)
I6J64_RS19375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J64_RS19375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J64_RS19380	COG0009	L-threonylcarbamoyladenylate synthase
I6J64_RS19385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J64_RS19390	COG0038	chloride channel
I6J64_RS19395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J64_RS19400	COG2832	Protein of unknown function (DUF454)
I6J64_RS19410	COG0545	Peptidyl-prolyl cis-trans isomerase
I6J64_RS19435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J64_RS19450	COG0784	Response regulator, receiver
I6J64_RS19450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J64_RS19450	COG2198	Histidine kinase
I6J64_RS19450	COG2205	protein histidine kinase activity
I6J64_RS19455	COG0420	3'-5' exonuclease activity
I6J64_RS19465	COG0778	Nitroreductase
I6J64_RS19470	COG0475	glutathione-regulated potassium exporter activity
I6J64_RS19475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J64_RS19480	COG1482	cell wall glycoprotein biosynthetic process
I6J64_RS19485	COG2818	Glycosylase
I6J64_RS19490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J64_RS19500	COG1151	hydroxylamine reductase activity
I6J64_RS19555	COG0228	four-way junction DNA binding
I6J64_RS19560	COG0488	(ABC) transporter
I6J64_RS19575	COG0252	asparaginase activity
I6J64_RS19580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J64_RS19605	COG0475	glutathione-regulated potassium exporter activity
I6J64_RS19605	COG0589	response to stress
I6J64_RS19620	COG1595	DNA-templated transcription, initiation
I6J64_RS19630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J64_RS19635	COG0658	competence protein
I6J64_RS19635	COG2333	competence protein COMEC
I6J64_RS19640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J64_RS19650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J64_RS19695	COG4771	TonB-dependent receptor
I6J64_RS19720	COG1629	transport
I6J64_RS19730	COG3119	arylsulfatase activity
I6J64_RS19735	COG3119	arylsulfatase activity
I6J64_RS19750	COG1368	sulfuric ester hydrolase activity
I6J64_RS19765	COG0698	ribose 5-phosphate isomerase
I6J64_RS19780	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J64_RS19815	COG1733	regulation of RNA biosynthetic process
I6J64_RS19825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J64_RS19850	COG2246	polysaccharide biosynthetic process
I6J64_RS19855	COG0463	Glycosyl transferase, family 2
I6J64_RS19865	COG3250	beta-galactosidase activity
I6J64_RS19870	COG3842	ATPase activity
I6J64_RS19875	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J64_RS19880	COG1177	transmembrane transport
I6J64_RS19885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J64_RS19890	COG1011	Hydrolase
I6J64_RS19895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6J64_RS19925	COG1136	(ABC) transporter
I6J64_RS19980	COG3537	Alpha-1,2-mannosidase
I6J64_RS19995	COG4771	TonB-dependent receptor