locus-tag	class	description
C2L64_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2L64_RS00010	COG0592	DNA-directed DNA polymerase activity
C2L64_RS00040	COG4303	Ethanolamine ammonia lyase large subunit
C2L64_RS00045	COG4302	ethanolamine ammonia-lyase activity
C2L64_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS00060	COG2207	Transcriptional regulator
C2L64_RS00070	COG0513	Belongs to the DEAD box helicase family
C2L64_RS00075	COG0436	Aminotransferase
C2L64_RS00080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2L64_RS00085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS00125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS00130	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C2L64_RS00135	COG0583	DNA-binding transcription factor activity
C2L64_RS00150	COG0758	DNA mediated transformation
C2L64_RS00155	COG0242	peptide deformylase activity
C2L64_RS00160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2L64_RS00170	COG0501	Belongs to the peptidase M48B family
C2L64_RS00185	COG5000	phosphorelay sensor kinase activity
C2L64_RS00190	COG2204	response regulator
C2L64_RS00200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2L64_RS00205	COG0602	queuosine metabolic process
C2L64_RS00210	COG0720	synthase
C2L64_RS00225	COG0772	Belongs to the SEDS family
C2L64_RS00230	COG0768	penicillin binding
C2L64_RS00240	COG1792	Involved in formation and maintenance of cell shape
C2L64_RS00245	COG1077	Cell shape determining protein MreB Mrl
C2L64_RS00250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2L64_RS00255	COG0154	amidase activity
C2L64_RS00260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2L64_RS00265	COG2326	polyphosphate kinase activity
C2L64_RS00270	COG0708	Exodeoxyribonuclease III
C2L64_RS00280	COG2814	Major facilitator Superfamily
C2L64_RS00290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS00295	COG1309	transcriptional regulator
C2L64_RS00305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2L64_RS00325	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C2L64_RS00330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2L64_RS00335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2L64_RS00345	COG0523	cobalamin synthesis protein
C2L64_RS00355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L64_RS00365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2L64_RS00370	COG1560	Kdo2-lipid A biosynthetic process
C2L64_RS00375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2L64_RS00395	COG0667	Aldo Keto reductase
C2L64_RS00405	COG2814	Major facilitator Superfamily
C2L64_RS00430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2L64_RS00450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2L64_RS00485	COG0531	amino acid
C2L64_RS00505	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS00510	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS00515	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS00520	COG1129	ABC transporter
C2L64_RS00525	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS00530	COG1609	Transcriptional regulator
C2L64_RS00540	COG3568	Endonuclease Exonuclease Phosphatase
C2L64_RS00550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2L64_RS00560	COG0579	oxidoreductase
C2L64_RS00575	COG0154	amidase activity
C2L64_RS00605	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L64_RS00615	COG1522	sequence-specific DNA binding
C2L64_RS00625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS00640	COG0792	nuclease activity
C2L64_RS00645	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2L64_RS00665	COG0582	viral genome integration into host DNA
C2L64_RS00670	COG0582	viral genome integration into host DNA
C2L64_RS00725	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2L64_RS00730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2L64_RS00735	COG1111	helicase
C2L64_RS00735	COG1205	dead DEAH box helicase
C2L64_RS00830	COG0210	DNA helicase
C2L64_RS00840	COG0537	adenosine 5'-monophosphoramidase activity
C2L64_RS00900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2L64_RS00905	COG1366	Belongs to the anti-sigma-factor antagonist family
C2L64_RS00910	COG1366	Belongs to the anti-sigma-factor antagonist family
C2L64_RS00915	COG2172	sigma factor antagonist activity
C2L64_RS00925	COG2205	protein histidine kinase activity
C2L64_RS00935	COG0784	Response regulator, receiver
C2L64_RS00935	COG4191	Histidine kinase
C2L64_RS00945	COG0840	transmembrane signaling receptor activity
C2L64_RS00950	COG2233	PERMEase
C2L64_RS00955	COG0025	NhaP-type Na H and K H
C2L64_RS00960	COG2200	EAL domain
C2L64_RS00960	COG2199	diguanylate cyclase activity
C2L64_RS00980	COG0625	glutathione transferase activity
C2L64_RS01010	COG1609	Transcriptional regulator
C2L64_RS01035	COG0583	DNA-binding transcription factor activity
C2L64_RS01040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS01040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS01040	COG1703	isobutyryl-CoA mutase activity
C2L64_RS01050	COG0596	Alpha beta hydrolase
C2L64_RS01065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS01090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L64_RS01110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2L64_RS01115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2L64_RS01120	COG0156	8-amino-7-oxononanoate synthase activity
C2L64_RS01135	COG3012	SEC-C Motif Domain Protein
C2L64_RS01140	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS01150	COG0183	Belongs to the thiolase family
C2L64_RS01155	COG0288	reversible hydration of carbon dioxide
C2L64_RS01160	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2L64_RS01165	COG0789	Transcriptional regulator
C2L64_RS01175	COG0747	negative chemotaxis
C2L64_RS01180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2L64_RS01190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2L64_RS01200	COG0018	arginyl-trna synthetase
C2L64_RS01220	COG0646	methionine synthase
C2L64_RS01220	COG1410	methionine synthase
C2L64_RS01235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS01260	COG1024	Enoyl-CoA hydratase
C2L64_RS01275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2L64_RS01285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2L64_RS01295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2L64_RS01300	COG1127	ABC transporter
C2L64_RS01330	COG1686	Belongs to the peptidase S11 family
C2L64_RS01335	COG2921	Belongs to the UPF0250 family
C2L64_RS01340	COG0583	DNA-binding transcription factor activity
C2L64_RS01350	COG0321	lipoyl(octanoyl) transferase activity
C2L64_RS01360	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2L64_RS01365	COG1349	DNA-binding transcription factor activity
C2L64_RS01370	COG0584	glycerophosphoryl diester phosphodiesterase
C2L64_RS01390	COG3842	ATPase activity
C2L64_RS01395	COG1301	dicarboxylic acid transport
C2L64_RS01400	COG4191	Histidine kinase
C2L64_RS01455	COG2960	long-chain fatty acid transporting porin activity
C2L64_RS01465	COG0004	ammonium transporteR
C2L64_RS01475	COG0189	ligase activity
C2L64_RS01485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L64_RS01490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2L64_RS01500	COG0793	Belongs to the peptidase S41A family
C2L64_RS01510	COG0588	phosphoglycerate mutase activity
C2L64_RS01515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2L64_RS01525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2L64_RS01530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2L64_RS01535	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2L64_RS01540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2L64_RS01550	COG2226	methyltransferase
C2L64_RS01565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L64_RS01570	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C2L64_RS01600	COG1612	heme a metabolic process
C2L64_RS01605	COG0109	protoheme IX farnesyltransferase activity
C2L64_RS01610	COG1999	signal sequence binding
C2L64_RS01620	COG0840	transmembrane signaling receptor activity
C2L64_RS01635	COG0456	acetyltransferase
C2L64_RS01635	COG1846	Transcriptional regulator
C2L64_RS01640	COG2188	Transcriptional regulator
C2L64_RS01645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2L64_RS01650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L64_RS01655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2L64_RS01655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L64_RS01660	COG2190	(PTS) system
C2L64_RS01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2L64_RS01660	COG1263	PTS System
C2L64_RS01670	COG1294	oxidase, subunit
C2L64_RS01700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS01705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2L64_RS01715	COG0625	glutathione transferase activity
C2L64_RS01725	COG0742	ribosomal rna small subunit methyltransferase
C2L64_RS01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2L64_RS01735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2L64_RS01745	COG0193	aminoacyl-tRNA hydrolase activity
C2L64_RS01750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2L64_RS01755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2L64_RS01765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2L64_RS01770	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C2L64_RS01780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2L64_RS01785	COG1194	a g-specific adenine glycosylase
C2L64_RS01795	COG1660	Displays ATPase and GTPase activities
C2L64_RS01800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2L64_RS01810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2L64_RS01815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2L64_RS01820	COG1137	ATPase activity
C2L64_RS01835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2L64_RS01850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2L64_RS01855	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS01885	COG2814	Major facilitator Superfamily
C2L64_RS01890	COG0629	single-stranded DNA binding
C2L64_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS01920	COG0583	DNA-binding transcription factor activity
C2L64_RS01930	COG0840	transmembrane signaling receptor activity
C2L64_RS01955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L64_RS01990	COG2197	response regulator
C2L64_RS01995	COG2201	protein-glutamate methylesterase activity
C2L64_RS02000	COG2197	response regulator
C2L64_RS02005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2L64_RS02030	COG0477	Major facilitator Superfamily
C2L64_RS02050	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2L64_RS02060	COG3415	Transposase
C2L64_RS02060	COG2801	Transposase and inactivated derivatives
C2L64_RS02065	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2L64_RS02065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2L64_RS02075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2L64_RS02095	COG2226	methyltransferase
C2L64_RS02110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2L64_RS02125	COG3344	reverse transcriptase
C2L64_RS02140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2L64_RS02145	COG0494	nUDIX hydrolase
C2L64_RS02160	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS02165	COG1024	Enoyl-CoA hydratase
C2L64_RS02165	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS02170	COG0183	Belongs to the thiolase family
C2L64_RS02175	COG1024	Enoyl-CoA hydratase
C2L64_RS02180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2L64_RS02195	COG1607	acyl-coa hydrolase
C2L64_RS02200	COG5265	(ABC) transporter
C2L64_RS02205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2L64_RS02215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2L64_RS02220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L64_RS02225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2L64_RS02230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2L64_RS02250	COG0204	Acyl-transferase
C2L64_RS02255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2L64_RS02260	COG0751	glycine-tRNA ligase activity
C2L64_RS02265	COG0752	glycyl-tRNA synthetase alpha subunit
C2L64_RS02270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2L64_RS02275	COG4535	Mg2 and Co2 transporter CorC
C2L64_RS02280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2L64_RS02285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2L64_RS02290	COG1702	phosphate starvation-inducible protein PhoH
C2L64_RS02295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2L64_RS02300	COG0583	DNA-binding transcription factor activity
C2L64_RS02310	COG2814	Major facilitator Superfamily
C2L64_RS02315	COG1396	sequence-specific DNA binding
C2L64_RS02320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2L64_RS02325	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS02330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L64_RS02335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2L64_RS02370	COG0513	Belongs to the DEAD box helicase family
C2L64_RS02375	COG1272	protein, Hemolysin III
C2L64_RS02410	COG2186	Transcriptional regulator
C2L64_RS02415	COG2814	Major facilitator Superfamily
C2L64_RS02430	COG0477	Major facilitator Superfamily
C2L64_RS02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2L64_RS02450	COG2137	regulation of response to DNA damage stimulus
C2L64_RS02460	COG0045	succinate-CoA ligase (ADP-forming) activity
C2L64_RS02465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2L64_RS02470	COG0861	Integral membrane protein TerC family
C2L64_RS02475	COG4969	Belongs to the N-Me-Phe pilin family
C2L64_RS02480	COG3344	reverse transcriptase
C2L64_RS02490	COG0315	cyclic pyranopterin monophosphate synthase activity
C2L64_RS02495	COG4783	chaperone-mediated protein folding
C2L64_RS02505	COG0429	hydrolase of the alpha beta-hydrolase fold
C2L64_RS02515	COG0859	PFAM glycosyl transferase family 9
C2L64_RS02540	COG0126	phosphoglycerate kinase activity
C2L64_RS02545	COG0469	pyruvate kinase activity
C2L64_RS02555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2L64_RS02560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2L64_RS02565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2L64_RS02570	COG0009	L-threonylcarbamoyladenylate synthase
C2L64_RS02595	COG0642	Histidine kinase
C2L64_RS02600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS02625	COG4977	sequence-specific DNA binding
C2L64_RS02640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS02645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS02665	COG2233	PERMEase
C2L64_RS02680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2L64_RS02685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2L64_RS02690	COG1121	(ABC) transporter
C2L64_RS02695	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2L64_RS02700	COG0735	belongs to the Fur family
C2L64_RS02715	COG1175	transmembrane transport
C2L64_RS02725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L64_RS02730	COG3842	ATPase activity
C2L64_RS02740	COG2390	Transcriptional regulator
C2L64_RS02745	COG1070	Carbohydrate kinase
C2L64_RS02750	COG0246	Mannitol dehydrogenase
C2L64_RS02760	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS02770	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS02775	COG1063	alcohol dehydrogenase
C2L64_RS02780	COG1070	Carbohydrate kinase
C2L64_RS02785	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS02795	COG3483	tryptophan 2,3-dioxygenase activity
C2L64_RS02805	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2L64_RS02810	COG1522	sequence-specific DNA binding
C2L64_RS02815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L64_RS02820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2L64_RS02830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L64_RS02835	COG0259	pyridoxamine-phosphate oxidase activity
C2L64_RS02840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2L64_RS02850	COG1741	Belongs to the pirin family
C2L64_RS02870	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2L64_RS02875	COG0802	atpase or kinase
C2L64_RS02880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2L64_RS02890	COG4974	Belongs to the 'phage' integrase family
C2L64_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS02905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2L64_RS02910	COG1666	GTP binding
C2L64_RS02915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2L64_RS02920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2L64_RS02930	COG0268	Binds directly to 16S ribosomal RNA
C2L64_RS02935	COG0728	peptidoglycan biosynthetic process
C2L64_RS02960	COG0563	adenylate kinase activity
C2L64_RS02965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2L64_RS02970	COG2835	tetraacyldisaccharide 4'-kinase activity
C2L64_RS02975	COG1663	tetraacyldisaccharide 4'-kinase activity
C2L64_RS02980	COG1570	exodeoxyribonuclease VII activity
C2L64_RS03005	COG1335	isochorismatase
C2L64_RS03010	COG1309	transcriptional regulator
C2L64_RS03015	COG0740	serine-type endopeptidase activity
C2L64_RS03020	COG1595	DNA-templated transcription, initiation
C2L64_RS03030	COG2814	Major facilitator Superfamily
C2L64_RS03055	COG2188	Transcriptional regulator
C2L64_RS03060	COG0656	L-ascorbic acid biosynthetic process
C2L64_RS03080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS03085	COG0601	transmembrane transport
C2L64_RS03090	COG0747	negative chemotaxis
C2L64_RS03095	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L64_RS03140	COG2132	Multicopper oxidase
C2L64_RS03145	COG1278	Cold shock
C2L64_RS03150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2L64_RS03155	COG0542	response to heat
C2L64_RS03160	COG0756	dUTP diphosphatase activity
C2L64_RS03165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS03170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2L64_RS03175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2L64_RS03180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2L64_RS03185	COG0196	riboflavin kinase activity
C2L64_RS03190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2L64_RS03195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2L64_RS03195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2L64_RS03200	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C2L64_RS03200	COG3264	Mechanosensitive ion channel
C2L64_RS03210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2L64_RS03220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2L64_RS03240	COG1047	Peptidyl-prolyl cis-trans
C2L64_RS03245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2L64_RS03250	COG0683	leucine binding
C2L64_RS03275	COG0456	acetyltransferase
C2L64_RS03280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2L64_RS03300	COG1187	pseudouridine synthase activity
C2L64_RS03305	COG4175	Glycine betaine
C2L64_RS03310	COG4176	ABC-type proline glycine betaine transport system permease component
C2L64_RS03320	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS03325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS03365	COG1968	undecaprenyl-diphosphatase activity
C2L64_RS03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2L64_RS03380	COG0762	integral membrane protein
C2L64_RS03410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2L64_RS03420	COG0436	Aminotransferase
C2L64_RS03425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2L64_RS03430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2L64_RS03445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2L64_RS03445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2L64_RS03450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2L64_RS03460	COG2814	Major facilitator Superfamily
C2L64_RS03465	COG0837	glucose binding
C2L64_RS03465	COG1737	Transcriptional regulator
C2L64_RS03470	COG0363	glucosamine-6-phosphate deaminase activity
C2L64_RS03475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2L64_RS03485	COG1175	transmembrane transport
C2L64_RS03490	COG0395	ABC-type sugar transport system, permease component
C2L64_RS03495	COG3842	ATPase activity
C2L64_RS03500	COG2860	membrane
C2L64_RS03505	COG1193	negative regulation of DNA recombination
C2L64_RS03510	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS03515	COG1674	ftsk spoiiie
C2L64_RS03520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2L64_RS03545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2L64_RS03550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2L64_RS03565	COG4191	Histidine kinase
C2L64_RS03570	COG4566	intracellular signal transduction
C2L64_RS03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS03600	COG2995	paraquat-inducible protein a
C2L64_RS03605	COG3008	intermembrane lipid transfer
C2L64_RS03605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L64_RS03615	COG0024	Methionine aminopeptidase
C2L64_RS03625	COG0850	regulation of cytokinetic process
C2L64_RS03630	COG2894	cell division
C2L64_RS03635	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2L64_RS03665	COG0477	Major facilitator Superfamily
C2L64_RS03695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2L64_RS03700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2L64_RS03705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2L64_RS03715	COG1561	YicC-like family, N-terminal region
C2L64_RS03720	COG0194	GDP metabolic process
C2L64_RS03730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2L64_RS03755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS03765	COG1278	Cold shock
C2L64_RS03770	COG0322	excinuclease ABC activity
C2L64_RS03785	COG4772	TonB-dependent receptor
C2L64_RS03820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2L64_RS03830	COG3549	Plasmid maintenance system killer
C2L64_RS03835	COG0308	aminopeptidase N
C2L64_RS03845	COG2119	membrane
C2L64_RS03865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2L64_RS03885	COG2986	histidine ammonia-lyase
C2L64_RS03905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L64_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS03920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L64_RS03940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2L64_RS03950	COG3328	transposase activity
C2L64_RS03955	COG0402	S-adenosylhomocysteine deaminase activity
C2L64_RS03960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C2L64_RS03980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2L64_RS03985	COG0154	amidase activity
C2L64_RS03990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2L64_RS03990	COG4651	solute:proton antiporter activity
C2L64_RS03995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2L64_RS04025	COG0640	Transcriptional regulator
C2L64_RS04045	COG3383	formate dehydrogenase (NAD+) activity
C2L64_RS04055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2L64_RS04060	COG1910	domain protein
C2L64_RS04075	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS04090	COG0546	phosphoglycolate phosphatase activity
C2L64_RS04095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2L64_RS04115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2L64_RS04125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2L64_RS04130	COG0287	Prephenate dehydrogenase
C2L64_RS04135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2L64_RS04140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2L64_RS04150	COG0776	regulation of translation
C2L64_RS04160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2L64_RS04170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2L64_RS04175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS04190	COG2951	lytic endotransglycosylase activity
C2L64_RS04195	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2L64_RS04200	COG1024	Enoyl-CoA hydratase
C2L64_RS04205	COG2267	carboxylic ester hydrolase activity
C2L64_RS04210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2L64_RS04215	COG2011	ABC-type metal ion transport system permease component
C2L64_RS04235	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS04240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS04265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2L64_RS04270	COG0336	Belongs to the RNA methyltransferase TrmD family
C2L64_RS04295	COG1162	GTPase activity
C2L64_RS04305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2L64_RS04310	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2L64_RS04315	COG3028	Belongs to the UPF0307 family
C2L64_RS04320	COG0312	modulator of DNA gyrase
C2L64_RS04330	COG2204	response regulator
C2L64_RS04375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2L64_RS04390	COG2814	Major facilitator Superfamily
C2L64_RS04405	COG0114	fumarate hydratase activity
C2L64_RS04410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2L64_RS04415	COG0534	Mate efflux family protein
C2L64_RS04420	COG2501	S4 domain
C2L64_RS04435	COG0210	DNA helicase
C2L64_RS04450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2L64_RS04460	COG3045	CreA protein
C2L64_RS04475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2L64_RS04500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS04505	COG1322	Protein conserved in bacteria
C2L64_RS04530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2L64_RS04535	COG1530	ribonuclease E activity
C2L64_RS04540	COG0564	pseudouridine synthase activity
C2L64_RS04545	COG0546	phosphoglycolate phosphatase activity
C2L64_RS04555	COG0616	signal peptide processing
C2L64_RS04555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2L64_RS04565	COG0424	maF-like protein
C2L64_RS04570	COG1399	metal-binding, possibly nucleic acid-binding protein
C2L64_RS04575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2L64_RS04585	COG0416	fatty acid biosynthetic process
C2L64_RS04590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2L64_RS04610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2L64_RS04635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS04645	COG3344	reverse transcriptase
C2L64_RS04650	COG0481	GTPase activity
C2L64_RS04655	COG0681	Belongs to the peptidase S26 family
C2L64_RS04660	COG0571	ribonuclease III activity
C2L64_RS04665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2L64_RS04670	COG1381	Involved in DNA repair and RecF pathway recombination
C2L64_RS04675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2L64_RS04680	COG0736	holo-[acyl-carrier-protein] synthase activity
C2L64_RS04690	COG2204	response regulator
C2L64_RS04695	COG3237	CsbD-like
C2L64_RS04700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2L64_RS04715	COG3344	reverse transcriptase
C2L64_RS04720	COG0322	excinuclease ABC activity
C2L64_RS04745	COG2153	protein acetylation
C2L64_RS04770	COG1877	trehalose-phosphatase activity
C2L64_RS04775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C2L64_RS04780	COG1132	(ABC) transporter
C2L64_RS04785	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS04805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2L64_RS04810	COG0328	RNA-DNA hybrid ribonuclease activity
C2L64_RS04815	COG2226	methyltransferase
C2L64_RS04820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS04825	COG0741	lytic transglycosylase activity
C2L64_RS04825	COG1388	LysM domain
C2L64_RS04830	COG2223	nitrite transmembrane transporter activity
C2L64_RS04835	COG0505	Belongs to the CarA family
C2L64_RS04840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2L64_RS04845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2L64_RS04855	COG1534	Rna-binding protein
C2L64_RS04860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2L64_RS04865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2L64_RS04870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2L64_RS04875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2L64_RS04885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2L64_RS04890	COG0573	inorganic phosphate transmembrane transporter activity
C2L64_RS04895	COG0581	inorganic phosphate transmembrane transporter activity
C2L64_RS04900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2L64_RS04910	COG0745	RESPONSE REGULATOR receiver
C2L64_RS04920	COG5295	Hep Hag repeat protein
C2L64_RS04925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C2L64_RS04965	COG0534	Mate efflux family protein
C2L64_RS04980	COG4942	peptidase
C2L64_RS04990	COG1968	undecaprenyl-diphosphatase activity
C2L64_RS05005	COG1858	cytochrome C peroxidase
C2L64_RS05020	COG1051	belongs to the nudix hydrolase family
C2L64_RS05030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2L64_RS05045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS05050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2L64_RS05060	COG0477	Major facilitator Superfamily
C2L64_RS05075	COG0824	Thioesterase
C2L64_RS05100	COG3718	enzyme involved in inositol metabolism
C2L64_RS05110	COG3962	Belongs to the TPP enzyme family
C2L64_RS05125	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS05140	COG0673	inositol 2-dehydrogenase activity
C2L64_RS05145	COG0673	inositol 2-dehydrogenase activity
C2L64_RS05150	COG0425	Belongs to the sulfur carrier protein TusA family
C2L64_RS05155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2L64_RS05160	COG0525	valine-tRNA ligase activity
C2L64_RS05165	COG0210	DNA helicase
C2L64_RS05170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2L64_RS05175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS05180	COG2223	nitrite transmembrane transporter activity
C2L64_RS05185	COG0840	transmembrane signaling receptor activity
C2L64_RS05195	COG3328	transposase activity
C2L64_RS05200	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS05220	COG0583	DNA-binding transcription factor activity
C2L64_RS05230	COG0277	FAD linked oxidase domain protein
C2L64_RS05245	COG1295	ribonuclease BN
C2L64_RS05275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2L64_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS05320	COG0251	oxidation-reduction process
C2L64_RS05325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2L64_RS05335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2L64_RS05340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2L64_RS05345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2L64_RS05355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2L64_RS05365	COG0776	regulation of translation
C2L64_RS05390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2L64_RS05395	COG1275	C4-dicarboxylate transporter malic acid transport protein
C2L64_RS05400	COG0625	glutathione transferase activity
C2L64_RS05405	COG3511	phospholipase C
C2L64_RS05430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2L64_RS05450	COG1309	transcriptional regulator
C2L64_RS05460	COG0493	'glutamate synthase
C2L64_RS05470	COG1953	Uracil, thiamine, allantoin
C2L64_RS05480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS05485	COG0765	amino acid transport
C2L64_RS05490	COG1126	abc transporter atp-binding protein
C2L64_RS05505	COG5295	Hep Hag repeat protein
C2L64_RS05520	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2L64_RS05535	COG1620	l-lactate permease
C2L64_RS05550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2L64_RS05565	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L64_RS05565	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS05575	COG5510	response to toxic substance
C2L64_RS05580	COG4585	Histidine kinase
C2L64_RS05600	COG2197	response regulator
C2L64_RS05605	COG2197	response regulator
C2L64_RS05610	COG2814	Major facilitator Superfamily
C2L64_RS05615	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2L64_RS05620	COG3842	ATPase activity
C2L64_RS05630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2L64_RS05635	COG1840	ABC-type Fe3 transport system, periplasmic component
C2L64_RS05640	COG1609	Transcriptional regulator
C2L64_RS05680	COG2026	Addiction module toxin, RelE StbE family
C2L64_RS05700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L64_RS05725	COG0477	Major facilitator Superfamily
C2L64_RS05730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2L64_RS05735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2L64_RS05735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2L64_RS05740	COG1643	Atp-dependent helicase
C2L64_RS05770	COG1546	Belongs to the CinA family
C2L64_RS05770	COG1058	Belongs to the CinA family
C2L64_RS05780	COG0174	glutamine synthetase
C2L64_RS05785	COG3852	Histidine kinase
C2L64_RS05805	COG1794	racemase activity, acting on amino acids and derivatives
C2L64_RS05810	COG0402	S-adenosylhomocysteine deaminase activity
C2L64_RS05815	COG0339	signal peptide processing
C2L64_RS05825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2L64_RS05840	COG3064	Membrane
C2L64_RS05845	COG4566	intracellular signal transduction
C2L64_RS05855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2L64_RS05860	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L64_RS05865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L64_RS05870	COG3415	Transposase
C2L64_RS05870	COG2801	Transposase and inactivated derivatives
C2L64_RS05890	COG1414	Transcriptional regulator
C2L64_RS05915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2L64_RS05925	COG1104	cysteine desulfurase activity
C2L64_RS05940	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2L64_RS05945	COG0443	Heat shock 70 kDa protein
C2L64_RS05950	COG0633	Ferredoxin
C2L64_RS05955	COG2975	iron-sulfur cluster assembly
C2L64_RS05965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2L64_RS05980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2L64_RS06000	COG1136	(ABC) transporter
C2L64_RS06005	COG0084	hydrolase, TatD family'
C2L64_RS06020	COG0504	CTP synthase activity
C2L64_RS06025	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2L64_RS06030	COG0148	phosphopyruvate hydratase activity
C2L64_RS06035	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2L64_RS06045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2L64_RS06055	COG2833	Protein of unknown function (DUF455)
C2L64_RS06065	COG0613	PHP domain protein
C2L64_RS06070	COG0009	L-threonylcarbamoyladenylate synthase
C2L64_RS06075	COG1994	Peptidase M50
C2L64_RS06080	COG0180	Tryptophanyl-tRNA synthetase
C2L64_RS06090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS06095	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2L64_RS06100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2L64_RS06105	COG0670	Belongs to the BI1 family
C2L64_RS06110	COG0105	UTP biosynthetic process
C2L64_RS06115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2L64_RS06125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2L64_RS06130	COG0124	histidyl-tRNA synthetase
C2L64_RS06140	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2L64_RS06150	COG1160	GTP binding
C2L64_RS06155	COG1923	regulation of RNA biosynthetic process
C2L64_RS06160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2L64_RS06165	COG0330	HflC and HflK could
C2L64_RS06175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C2L64_RS06180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2L64_RS06185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2L64_RS06190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C2L64_RS06195	COG3158	transport of potassium into the cell
C2L64_RS06200	COG2183	response to ionizing radiation
C2L64_RS06215	COG1199	ATP-dependent helicase activity
C2L64_RS06230	COG2850	peptidyl-arginine hydroxylation
C2L64_RS06245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2L64_RS06250	COG0477	Major facilitator Superfamily
C2L64_RS06255	COG0483	inositol monophosphate 1-phosphatase activity
C2L64_RS06265	COG1045	serine acetyltransferase
C2L64_RS06270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2L64_RS06275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2L64_RS06280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2L64_RS06290	COG0215	cysteine-tRNA ligase activity
C2L64_RS06300	COG0825	malonyl-CoA metabolic process
C2L64_RS06305	COG0037	tRNA processing
C2L64_RS06310	COG0527	aspartate kinase activity
C2L64_RS06330	COG4166	transmembrane transport
C2L64_RS06335	COG4174	ABC transporter (Permease)
C2L64_RS06340	COG4239	(ABC) transporter, permease
C2L64_RS06345	COG4172	Belongs to the ABC transporter superfamily
C2L64_RS06350	COG0791	NLP P60 protein
C2L64_RS06355	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2L64_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2L64_RS06400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS06410	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2L64_RS06420	COG0583	DNA-binding transcription factor activity
C2L64_RS06430	COG2224	Isocitrate lyase
C2L64_RS06440	COG0513	Belongs to the DEAD box helicase family
C2L64_RS06450	COG1214	PFAM Peptidase M22, glycoprotease
C2L64_RS06460	COG1573	uracil-dna glycosylase
C2L64_RS06470	COG0351	phosphomethylpyrimidine kinase
C2L64_RS06475	COG0477	Major facilitator Superfamily
C2L64_RS06480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2L64_RS06495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS06500	COG0488	(ABC) transporter
C2L64_RS06505	COG0386	Belongs to the glutathione peroxidase family
C2L64_RS06515	COG2890	protein-(glutamine-N5) methyltransferase activity
C2L64_RS06520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2L64_RS06525	COG1393	Belongs to the ArsC family
C2L64_RS06530	COG2171	N-acyltransferase activity
C2L64_RS06560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2L64_RS06565	COG0242	peptide deformylase activity
C2L64_RS06570	COG1187	pseudouridine synthase activity
C2L64_RS06590	COG0052	Belongs to the universal ribosomal protein uS2 family
C2L64_RS06595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2L64_RS06600	COG0528	UMP kinase activity
C2L64_RS06605	COG0233	cytoplasmic translational termination
C2L64_RS06610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2L64_RS06620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2L64_RS06625	COG0750	zinc metalloprotease
C2L64_RS06640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2L64_RS06650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2L64_RS06655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2L64_RS06660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2L64_RS06665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2L64_RS06670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2L64_RS06695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2L64_RS06705	COG2914	Belongs to the UPF0125 (RnfH) family
C2L64_RS06710	COG0697	spore germination
C2L64_RS06730	COG0519	Catalyzes the synthesis of GMP from XMP
C2L64_RS06730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2L64_RS06745	COG1573	uracil-dna glycosylase
C2L64_RS06760	COG0531	amino acid
C2L64_RS06790	COG0590	tRNA wobble adenosine to inosine editing
C2L64_RS06795	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2L64_RS06800	COG1802	Transcriptional regulator
C2L64_RS06805	COG1953	Uracil, thiamine, allantoin
C2L64_RS06820	COG3648	Uricase
C2L64_RS06820	COG3195	allantoin biosynthetic process
C2L64_RS06825	COG4266	Belongs to the allantoicase family
C2L64_RS06845	COG2351	hydroxyisourate hydrolase activity
C2L64_RS06865	COG3845	ABC transporter
C2L64_RS06870	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS06875	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS06885	COG3360	Dodecin
C2L64_RS06895	COG0488	(ABC) transporter
C2L64_RS06905	COG2070	2-Nitropropane dioxygenase
C2L64_RS06910	COG3047	cAMP biosynthetic process
C2L64_RS06925	COG1914	H( )-stimulated, divalent metal cation uptake system
C2L64_RS06930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2L64_RS06935	COG3842	ATPase activity
C2L64_RS06940	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS06945	COG1177	transmembrane transport
C2L64_RS06950	COG0840	transmembrane signaling receptor activity
C2L64_RS06995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS07000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS07010	COG0662	Cupin 2, conserved barrel domain protein
C2L64_RS07035	COG0038	chloride channel
C2L64_RS07045	COG2855	membrane
C2L64_RS07060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L64_RS07070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS07075	COG1609	Transcriptional regulator
C2L64_RS07080	COG4377	Putative membrane peptidase family (DUF2324)
C2L64_RS07100	COG0583	DNA-binding transcription factor activity
C2L64_RS07120	COG4691	Plasmid stability protein
C2L64_RS07135	COG0598	Magnesium transport protein CorA
C2L64_RS07140	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS07145	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS07150	COG1129	ABC transporter
C2L64_RS07155	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS07160	COG1609	Transcriptional regulator
C2L64_RS07165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L64_RS07170	COG0840	transmembrane signaling receptor activity
C2L64_RS07190	COG2766	serine protein kinase
C2L64_RS07195	COG2718	Belongs to the UPF0229 family
C2L64_RS07200	COG2719	SpoVR family
C2L64_RS07205	COG0477	Major facilitator Superfamily
C2L64_RS07210	COG1216	Glycosyl transferase, family 2
C2L64_RS07230	COG2814	Major facilitator Superfamily
C2L64_RS07235	COG0668	transmembrane transport
C2L64_RS07250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2L64_RS07260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS07280	COG2116	formate transmembrane transporter activity
C2L64_RS07305	COG4566	intracellular signal transduction
C2L64_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS07315	COG0154	amidase activity
C2L64_RS07335	COG4191	Histidine kinase
C2L64_RS07365	COG0604	alcohol dehydrogenase
C2L64_RS07425	COG1070	Carbohydrate kinase
C2L64_RS07435	COG3038	cytochrome b561
C2L64_RS07455	COG2203	Gaf domain
C2L64_RS07455	COG3706	GGDEF domain
C2L64_RS07455	COG4251	negative regulation of phosphorylation
C2L64_RS07455	COG5001	Diguanylate cyclase
C2L64_RS07480	COG1649	PFAM Uncharacterised BCR, COG1649
C2L64_RS07480	COG0726	polysaccharide deacetylase
C2L64_RS07485	COG1215	transferase activity, transferring glycosyl groups
C2L64_RS07495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L64_RS07540	COG0642	Histidine kinase
C2L64_RS07570	COG3394	polysaccharide catabolic process
C2L64_RS07580	COG0735	belongs to the Fur family
C2L64_RS07590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS07610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2L64_RS07615	COG2962	Rard protein
C2L64_RS07630	COG1201	RNA secondary structure unwinding
C2L64_RS07635	COG0477	Major facilitator Superfamily
C2L64_RS07675	COG0583	DNA-binding transcription factor activity
C2L64_RS07685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS07705	COG2814	Major facilitator Superfamily
C2L64_RS07715	COG2814	Major facilitator Superfamily
C2L64_RS07720	COG0667	Aldo Keto reductase
C2L64_RS07735	COG2271	Major facilitator Superfamily
C2L64_RS07745	COG2721	sulfolactate sulfo-lyase activity
C2L64_RS07760	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS07785	COG0148	phosphopyruvate hydratase activity
C2L64_RS07795	COG0840	transmembrane signaling receptor activity
C2L64_RS07805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L64_RS07810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS07815	COG0583	DNA-binding transcription factor activity
C2L64_RS07820	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS07835	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS07850	COG1609	Transcriptional regulator
C2L64_RS07860	COG2271	Major facilitator Superfamily
C2L64_RS07865	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS07875	COG3038	cytochrome b561
C2L64_RS07880	COG0583	DNA-binding transcription factor activity
C2L64_RS07885	COG1301	dicarboxylic acid transport
C2L64_RS07900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2L64_RS07915	COG1881	PFAM PEBP family protein
C2L64_RS07920	COG1278	Cold shock
C2L64_RS07925	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS07955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2L64_RS07970	COG0513	Belongs to the DEAD box helicase family
C2L64_RS07985	COG0765	amino acid transport
C2L64_RS07990	COG0765	amino acid transport
C2L64_RS07995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS08045	COG1309	transcriptional regulator
C2L64_RS08050	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS08060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS08075	COG2271	Major facilitator Superfamily
C2L64_RS08105	COG2814	Major facilitator Superfamily
C2L64_RS08110	COG0583	DNA-binding transcription factor activity
C2L64_RS08115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L64_RS08120	COG0246	Mannitol dehydrogenase
C2L64_RS08125	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS08135	COG1063	alcohol dehydrogenase
C2L64_RS08140	COG2271	Major facilitator Superfamily
C2L64_RS08145	COG1802	Transcriptional regulator
C2L64_RS08160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS08185	COG2010	Cytochrome c
C2L64_RS08185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS08190	COG2080	2 iron, 2 sulfur cluster binding
C2L64_RS08195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS08195	COG2010	Cytochrome c
C2L64_RS08200	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS08210	COG0583	DNA-binding transcription factor activity
C2L64_RS08230	COG0667	Aldo Keto reductase
C2L64_RS08260	COG1733	regulation of RNA biosynthetic process
C2L64_RS08265	COG3328	transposase activity
C2L64_RS08285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS08315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2L64_RS08350	COG0154	amidase activity
C2L64_RS08365	COG0765	amino acid transport
C2L64_RS08370	COG0765	amino acid transport
C2L64_RS08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS08415	COG2801	Transposase and inactivated derivatives
C2L64_RS08425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS08430	COG1082	Xylose isomerase domain protein TIM barrel
C2L64_RS08430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2L64_RS08435	COG3246	L-lysine catabolic process to acetate
C2L64_RS08440	COG1414	Transcriptional regulator
C2L64_RS08450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2L64_RS08460	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS08485	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2L64_RS08490	COG3550	peptidyl-serine autophosphorylation
C2L64_RS08495	COG1396	sequence-specific DNA binding
C2L64_RS08500	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS08505	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS08525	COG0489	protein tyrosine kinase activity
C2L64_RS08525	COG3206	protein involved in exopolysaccharide biosynthesis
C2L64_RS08530	COG1596	polysaccharide export
C2L64_RS08545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2L64_RS08580	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS08605	COG0084	hydrolase, TatD family'
C2L64_RS08610	COG1247	-acetyltransferase
C2L64_RS08620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2L64_RS08625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2L64_RS08630	COG0354	folic acid binding
C2L64_RS08650	COG2130	NADP-dependent
C2L64_RS08690	COG0183	Belongs to the thiolase family
C2L64_RS08695	COG1335	isochorismatase
C2L64_RS08700	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS08700	COG1024	Enoyl-CoA hydratase
C2L64_RS08705	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS08710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2L64_RS08715	COG2917	probably involved in intracellular septation
C2L64_RS08725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L64_RS08730	COG0047	phosphoribosylformylglycinamidine synthase activity
C2L64_RS08730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2L64_RS08735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS08745	COG0166	Belongs to the GPI family
C2L64_RS08750	COG4181	ATPase activity
C2L64_RS08785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2L64_RS08790	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2L64_RS08795	COG0740	serine-type endopeptidase activity
C2L64_RS08800	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2L64_RS08805	COG1929	Belongs to the glycerate kinase type-1 family
C2L64_RS08850	COG0450	alkyl hydroperoxide reductase
C2L64_RS08855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS08860	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2L64_RS08860	COG2755	lipolytic protein G-D-S-L family
C2L64_RS08865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2L64_RS08870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2L64_RS08875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2L64_RS08895	COG1970	mechanosensitive ion channel activity
C2L64_RS08900	COG5002	protein histidine kinase activity
C2L64_RS08905	COG3437	response regulator, receiver
C2L64_RS08910	COG4251	negative regulation of phosphorylation
C2L64_RS08920	COG2982	Protein involved in outer membrane biogenesis
C2L64_RS08925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2L64_RS08930	COG0390	transport system, permease component
C2L64_RS08945	COG0583	DNA-binding transcription factor activity
C2L64_RS08965	COG2124	cytochrome p450
C2L64_RS08970	COG5434	Belongs to the glycosyl hydrolase 28 family
C2L64_RS08975	COG0560	Phosphoserine phosphatase
C2L64_RS08980	COG0626	cystathionine gamma-synthase activity
C2L64_RS08990	COG0183	Belongs to the thiolase family
C2L64_RS08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L64_RS09000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2L64_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS09025	COG0183	Belongs to the thiolase family
C2L64_RS09030	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2L64_RS09035	COG1496	oxidoreductase activity
C2L64_RS09040	COG0564	pseudouridine synthase activity
C2L64_RS09050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2L64_RS09075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2L64_RS09080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2L64_RS09085	COG0604	alcohol dehydrogenase
C2L64_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS09085	COG3321	synthase
C2L64_RS09090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS09105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS09110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2L64_RS09115	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2L64_RS09135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2L64_RS09140	COG0789	Transcriptional regulator
C2L64_RS09150	COG0254	rRNA binding
C2L64_RS09160	COG0534	Mate efflux family protein
C2L64_RS09175	COG2373	Large extracellular alpha-helical protein
C2L64_RS09180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2L64_RS09190	COG3753	Protein conserved in bacteria
C2L64_RS09195	COG0542	response to heat
C2L64_RS09200	COG1959	2 iron, 2 sulfur cluster binding
C2L64_RS09210	COG0314	molybdopterin synthase activity
C2L64_RS09215	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2L64_RS09235	COG0436	Aminotransferase
C2L64_RS09270	COG2076	Multidrug Resistance protein
C2L64_RS09275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2L64_RS09280	COG0463	Glycosyl transferase, family 2
C2L64_RS09295	COG0726	polysaccharide deacetylase
C2L64_RS09300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2L64_RS09305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2L64_RS09310	COG0791	NLP P60 protein
C2L64_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS09320	COG0306	phosphate transporter
C2L64_RS09335	COG0359	binds to the 23S rRNA
C2L64_RS09340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2L64_RS09350	COG0360	Binds together with S18 to 16S ribosomal RNA
C2L64_RS09360	COG1595	DNA-templated transcription, initiation
C2L64_RS09375	COG0583	DNA-binding transcription factor activity
C2L64_RS09380	COG3960	tartronate-semialdehyde synthase activity
C2L64_RS09385	COG3622	Belongs to the hyi family
C2L64_RS09390	COG2084	Dehydrogenase
C2L64_RS09400	COG2863	cytochrome
C2L64_RS09410	COG0252	asparaginase activity
C2L64_RS09415	COG0583	DNA-binding transcription factor activity
C2L64_RS09420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2L64_RS09425	COG4208	sulfate ABC transporter
C2L64_RS09430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2L64_RS09435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2L64_RS09440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2L64_RS09460	COG1131	(ABC) transporter
C2L64_RS09475	COG0701	Predicted permease
C2L64_RS09480	COG0667	Aldo Keto reductase
C2L64_RS09485	COG0477	Major facilitator Superfamily
C2L64_RS09490	COG3530	Putative quorum-sensing-regulated virulence factor
C2L64_RS09515	COG1598	PFAM Uncharacterised protein family UPF0150
C2L64_RS09540	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2L64_RS09540	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2L64_RS09560	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2L64_RS09605	COG1396	sequence-specific DNA binding
C2L64_RS09710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2L64_RS09740	COG1116	anion transmembrane transporter activity
C2L64_RS09745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS09750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS09805	COG4702	Belongs to the UPF0303 family
C2L64_RS09820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2L64_RS09825	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2L64_RS09830	COG0167	dihydroorotate dehydrogenase activity
C2L64_RS09840	COG0673	inositol 2-dehydrogenase activity
C2L64_RS09885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2L64_RS09890	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2L64_RS09895	COG3328	transposase activity
C2L64_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2L64_RS09905	COG0557	exoribonuclease II activity
C2L64_RS09925	COG2814	Major facilitator Superfamily
C2L64_RS09935	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS09955	COG0183	Belongs to the thiolase family
C2L64_RS09960	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS09995	COG1923	regulation of RNA biosynthetic process
C2L64_RS10010	COG3604	Transcriptional regulator
C2L64_RS10030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2L64_RS10035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L64_RS10040	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L64_RS10045	COG0567	Dehydrogenase, E1 component
C2L64_RS10065	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS10070	COG2814	Major facilitator Superfamily
C2L64_RS10080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2L64_RS10095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2L64_RS10100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2L64_RS10105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2L64_RS10110	COG0195	Participates in both transcription termination and antitermination
C2L64_RS10110	COG2251	uridine kinase activity
C2L64_RS10115	COG0779	Required for maturation of 30S ribosomal subunits
C2L64_RS10120	COG1187	pseudouridine synthase activity
C2L64_RS10125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2L64_RS10130	COG0436	Aminotransferase
C2L64_RS10135	COG0583	DNA-binding transcription factor activity
C2L64_RS10175	COG2200	EAL domain
C2L64_RS10190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2L64_RS10195	COG1074	ATP-dependent DNA helicase activity
C2L64_RS10200	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2L64_RS10215	COG1522	sequence-specific DNA binding
C2L64_RS10230	COG0668	transmembrane transport
C2L64_RS10240	COG1959	2 iron, 2 sulfur cluster binding
C2L64_RS10255	COG0693	protein deglycase activity
C2L64_RS10265	COG4251	negative regulation of phosphorylation
C2L64_RS10275	COG0004	ammonium transporteR
C2L64_RS10280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2L64_RS10325	COG0129	dihydroxy-acid dehydratase activity
C2L64_RS10330	COG0683	leucine binding
C2L64_RS10335	COG0583	DNA-binding transcription factor activity
C2L64_RS10345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2L64_RS10350	COG3622	Belongs to the hyi family
C2L64_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS10365	COG1733	regulation of RNA biosynthetic process
C2L64_RS10375	COG0625	glutathione transferase activity
C2L64_RS10395	COG3938	Belongs to the proline racemase family
C2L64_RS10425	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2L64_RS10450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS10460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS10475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2L64_RS10490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2L64_RS10500	COG0641	radical SAM
C2L64_RS10505	COG3119	arylsulfatase activity
C2L64_RS10525	COG1538	Outer membrane efflux protein
C2L64_RS10530	COG2988	succinylglutamate desuccinylase activity
C2L64_RS10535	COG3724	N-succinylarginine dihydrolase activity
C2L64_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS10555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2L64_RS10560	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS10580	COG4215	(ABC) transporter
C2L64_RS10585	COG4106	trans-aconitate 2-methyltransferase activity
C2L64_RS10590	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2L64_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS10610	COG0596	Alpha beta hydrolase
C2L64_RS10615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2L64_RS10630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C2L64_RS10670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS10680	COG3300	MHYT domain
C2L64_RS10680	COG5001	Diguanylate cyclase
C2L64_RS10690	COG0840	transmembrane signaling receptor activity
C2L64_RS10720	COG2197	response regulator
C2L64_RS10745	COG1228	amidohydrolase
C2L64_RS10755	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2L64_RS10765	COG2986	histidine ammonia-lyase
C2L64_RS10820	COG2252	PERMEase
C2L64_RS10835	COG3415	Transposase
C2L64_RS10835	COG2801	Transposase and inactivated derivatives
C2L64_RS10845	COG1473	amidohydrolase
C2L64_RS10865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS10875	COG0583	DNA-binding transcription factor activity
C2L64_RS10880	COG1252	NADH dehydrogenase
C2L64_RS10940	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS10945	COG1683	Conserved Protein
C2L64_RS10985	COG1522	sequence-specific DNA binding
C2L64_RS10990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS10995	COG1285	pathogenesis
C2L64_RS11015	COG3493	citrate carrier protein
C2L64_RS11020	COG2031	fatty acid transporter
C2L64_RS11050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS11060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS11090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2L64_RS11105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C2L64_RS11145	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2L64_RS11155	COG0672	)-iron permease
C2L64_RS11160	COG4633	Protein conserved in bacteria
C2L64_RS11170	COG0556	nucleotide-excision repair
C2L64_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS11190	COG0667	Aldo Keto reductase
C2L64_RS11195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2L64_RS11215	COG0789	Transcriptional regulator
C2L64_RS11230	COG0587	DNA-directed DNA polymerase activity
C2L64_RS11270	COG0628	permease
C2L64_RS11295	COG2866	Carboxypeptidase
C2L64_RS11300	COG3022	response to hydroperoxide
C2L64_RS11310	COG0436	Aminotransferase
C2L64_RS11315	COG0625	glutathione transferase activity
C2L64_RS11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS11325	COG1024	Enoyl-CoA hydratase
C2L64_RS11340	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS11345	COG0625	glutathione transferase activity
C2L64_RS11355	COG2030	dehydratase
C2L64_RS11360	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS11365	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS11385	COG1007	ATP synthesis coupled electron transport
C2L64_RS11400	COG0713	ATP synthesis coupled electron transport
C2L64_RS11410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L64_RS11415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2L64_RS11420	COG1034	ATP synthesis coupled electron transport
C2L64_RS11430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2L64_RS11435	COG0649	NAD binding
C2L64_RS11440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L64_RS11445	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L64_RS11450	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L64_RS11465	COG0149	triose-phosphate isomerase activity
C2L64_RS11470	COG0604	alcohol dehydrogenase
C2L64_RS11470	COG4221	oxidoreductase activity
C2L64_RS11470	COG3321	synthase
C2L64_RS11470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L64_RS11475	COG1185	polyribonucleotide nucleotidyltransferase activity
C2L64_RS11480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2L64_RS11485	COG0683	leucine binding
C2L64_RS11495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS11500	COG1183	phosphatidylcholine synthase activity
C2L64_RS11505	COG0688	phosphatidylethanolamine metabolic process
C2L64_RS11510	COG3344	reverse transcriptase
C2L64_RS11515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2L64_RS11525	COG0028	Belongs to the TPP enzyme family
C2L64_RS11560	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS11575	COG2801	Transposase and inactivated derivatives
C2L64_RS11575	COG3415	Transposase
C2L64_RS11580	COG1309	transcriptional regulator
C2L64_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS11600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2L64_RS11620	COG2076	Multidrug Resistance protein
C2L64_RS11625	COG0745	RESPONSE REGULATOR receiver
C2L64_RS11630	COG2205	protein histidine kinase activity
C2L64_RS11635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C2L64_RS11640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2L64_RS11645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2L64_RS11670	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS11675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2L64_RS11680	COG0217	transcriptional regulatory protein
C2L64_RS11690	COG0151	Belongs to the GarS family
C2L64_RS11695	COG0408	coproporphyrinogen oxidase activity
C2L64_RS11700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2L64_RS11705	COG0799	negative regulation of ribosome biogenesis
C2L64_RS11710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2L64_RS11715	COG0424	maF-like protein
C2L64_RS11720	COG1530	ribonuclease E activity
C2L64_RS11740	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS11765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2L64_RS11770	COG0513	Belongs to the DEAD box helicase family
C2L64_RS11780	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS11800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2L64_RS11810	COG1674	ftsk spoiiie
C2L64_RS11810	COG1674	ftsk spoiiie
C2L64_RS11815	COG2706	6-phosphogluconolactonase activity
C2L64_RS11830	COG3387	PFAM Glycoside hydrolase 15-related
C2L64_RS11840	COG1309	transcriptional regulator
C2L64_RS11845	COG2878	Part of a membrane complex involved in electron transport
C2L64_RS11850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2L64_RS11880	COG3135	benzoate transporter
C2L64_RS11885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2L64_RS11920	COG3161	chorismate lyase activity
C2L64_RS11930	COG0326	Molecular chaperone. Has ATPase activity
C2L64_RS11945	COG0697	spore germination
C2L64_RS11950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS11960	COG0384	phenazine biosynthesis protein PhzF
C2L64_RS11970	COG2059	Chromate
C2L64_RS11995	COG0488	(ABC) transporter
C2L64_RS12010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2L64_RS12040	COG1881	PFAM PEBP family protein
C2L64_RS12045	COG2814	Major facilitator Superfamily
C2L64_RS12085	COG2204	response regulator
C2L64_RS12100	COG2204	response regulator
C2L64_RS12115	COG1116	anion transmembrane transporter activity
C2L64_RS12150	COG1741	Belongs to the pirin family
C2L64_RS12155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS12195	COG2827	Endonuclease containing a URI domain
C2L64_RS12205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2L64_RS12210	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS12220	COG2271	Major facilitator Superfamily
C2L64_RS12225	COG3415	Transposase
C2L64_RS12225	COG2801	Transposase and inactivated derivatives
C2L64_RS12240	COG0181	hydroxymethylbilane synthase activity
C2L64_RS12250	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2L64_RS12255	COG2226	methyltransferase
C2L64_RS12265	COG0165	Argininosuccinate lyase
C2L64_RS12270	COG3781	membrane
C2L64_RS12300	COG0717	Belongs to the dCTP deaminase family
C2L64_RS12310	COG0489	protein tyrosine kinase activity
C2L64_RS12315	COG2885	chlorophyll binding
C2L64_RS12320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2L64_RS12320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2L64_RS12325	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
C2L64_RS12350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2L64_RS12355	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2L64_RS12375	COG1492	cobalamin metabolic process
C2L64_RS12385	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C2L64_RS12395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2L64_RS12405	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C2L64_RS12410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C2L64_RS12415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C2L64_RS12420	COG4139	cobalamin transport
C2L64_RS12425	COG4206	TonB-dependent receptor
C2L64_RS12455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2L64_RS12460	COG0583	DNA-binding transcription factor activity
C2L64_RS12485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2L64_RS12515	COG2895	sulfate adenylyltransferase (ATP) activity
C2L64_RS12525	COG0175	sulfate reduction
C2L64_RS12540	COG0583	DNA-binding transcription factor activity
C2L64_RS12560	COG0673	inositol 2-dehydrogenase activity
C2L64_RS12570	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS12575	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS12580	COG1129	ABC transporter
C2L64_RS12585	COG1609	Transcriptional regulator
C2L64_RS12590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2L64_RS12620	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS12630	COG1129	ABC transporter
C2L64_RS12650	COG0829	nickel cation binding
C2L64_RS12660	COG0831	urea catabolic process
C2L64_RS12665	COG0832	Belongs to the urease beta subunit family
C2L64_RS12670	COG0804	urea catabolic process
C2L64_RS12680	COG0675	Transposase, IS605 OrfB family
C2L64_RS12685	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C2L64_RS12690	COG0830	nickel cation binding
C2L64_RS12695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C2L64_RS12730	COG1196	nuclear chromosome segregation
C2L64_RS12730	COG0739	heme binding
C2L64_RS12730	COG0741	lytic transglycosylase activity
C2L64_RS12750	COG0154	amidase activity
C2L64_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS12790	COG3246	L-lysine catabolic process to acetate
C2L64_RS12805	COG0628	permease
C2L64_RS12820	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C2L64_RS12825	COG0288	reversible hydration of carbon dioxide
C2L64_RS12830	COG2995	paraquat-inducible protein a
C2L64_RS12875	COG1595	DNA-templated transcription, initiation
C2L64_RS12885	COG3220	belongs to the UPF0276 family
C2L64_RS12950	COG0625	glutathione transferase activity
C2L64_RS12975	COG3220	belongs to the UPF0276 family
C2L64_RS12995	COG5002	protein histidine kinase activity
C2L64_RS13000	COG0745	RESPONSE REGULATOR receiver
C2L64_RS13015	COG1252	NADH dehydrogenase
C2L64_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS13040	COG3321	synthase
C2L64_RS13040	COG0604	alcohol dehydrogenase
C2L64_RS13045	COG0288	reversible hydration of carbon dioxide
C2L64_RS13120	COG0628	permease
C2L64_RS13195	COG2801	Transposase and inactivated derivatives
C2L64_RS13210	COG3415	Transposase
C2L64_RS13250	COG1733	regulation of RNA biosynthetic process
C2L64_RS13315	COG3511	phospholipase C
C2L64_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS13365	COG1944	ATP diphosphatase activity
C2L64_RS13370	COG0488	(ABC) transporter
C2L64_RS13510	COG4191	Histidine kinase
C2L64_RS13590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2L64_RS13640	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS13780	COG0840	transmembrane signaling receptor activity
C2L64_RS13845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2L64_RS13875	COG3039	Transposase
C2L64_RS13905	COG0463	Glycosyl transferase, family 2
C2L64_RS13915	COG3958	Transketolase
C2L64_RS13920	COG3959	Transketolase, thiamine diphosphate binding domain
C2L64_RS13950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2L64_RS13970	COG2226	methyltransferase
C2L64_RS14005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS14010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2L64_RS14020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2L64_RS14030	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2L64_RS14035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2L64_RS14045	COG1678	Uncharacterized ACR, COG1678
C2L64_RS14055	COG1773	rubredoxin
C2L64_RS14065	COG0529	Catalyzes the synthesis of activated sulfate
C2L64_RS14070	COG0459	protein refolding
C2L64_RS14075	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2L64_RS14130	COG3344	reverse transcriptase
C2L64_RS14140	COG1484	DNA-dependent DNA replication
C2L64_RS14145	COG4584	PFAM Integrase catalytic
C2L64_RS14175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS14225	COG2223	nitrite transmembrane transporter activity
C2L64_RS14235	COG4214	carbohydrate transport
C2L64_RS14240	COG1129	ABC transporter
C2L64_RS14245	COG4213	ABC transporter substrate-binding protein
C2L64_RS14250	COG2115	Belongs to the xylose isomerase family
C2L64_RS14260	COG1609	Transcriptional regulator
C2L64_RS14260	COG2207	Transcriptional regulator
C2L64_RS14265	COG2017	converts alpha-aldose to the beta-anomer
C2L64_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS14285	COG1309	transcriptional regulator
C2L64_RS14295	COG0395	ABC-type sugar transport system, permease component
C2L64_RS14330	COG0789	Transcriptional regulator
C2L64_RS14340	COG4191	Histidine kinase
C2L64_RS14340	COG0784	Response regulator, receiver
C2L64_RS14350	COG0667	Aldo Keto reductase
C2L64_RS14355	COG1881	PFAM PEBP family protein
C2L64_RS14375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2L64_RS14390	COG2205	protein histidine kinase activity
C2L64_RS14420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS14425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS14435	COG2962	Rard protein
C2L64_RS14445	COG0730	response to heat
C2L64_RS14460	COG2823	Periplasmic or secreted lipoprotein
C2L64_RS14485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS14500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L64_RS14515	COG0583	DNA-binding transcription factor activity
C2L64_RS14520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS14530	COG1024	Enoyl-CoA hydratase
C2L64_RS14535	COG2814	Major facilitator Superfamily
C2L64_RS14570	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS14580	COG0450	alkyl hydroperoxide reductase
C2L64_RS14605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2L64_RS14615	COG4221	oxidoreductase activity
C2L64_RS14620	COG0824	Thioesterase
C2L64_RS14640	COG0823	Involved in the tonB-independent uptake of proteins
C2L64_RS14660	COG1596	polysaccharide export
C2L64_RS14665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS14690	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS14695	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS14710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2L64_RS14725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2L64_RS14735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L64_RS14740	COG5433	transposase activity
C2L64_RS14755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2L64_RS14755	COG2755	lipolytic protein G-D-S-L family
C2L64_RS14760	COG1073	alpha beta
C2L64_RS14760	COG2226	methyltransferase
C2L64_RS14790	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS14820	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS14840	COG0297	glycogen (starch) synthase activity
C2L64_RS14845	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS14850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS14855	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C2L64_RS14860	COG0489	protein tyrosine kinase activity
C2L64_RS14860	COG3206	protein involved in exopolysaccharide biosynthesis
C2L64_RS14865	COG1596	polysaccharide export
C2L64_RS14895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2L64_RS14905	COG0477	Major facilitator Superfamily
C2L64_RS14920	COG0586	Pfam SNARE associated Golgi protein
C2L64_RS14925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2L64_RS14930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2L64_RS14935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2L64_RS14940	COG0628	permease
C2L64_RS14945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2L64_RS14955	COG0617	tRNA 3'-terminal CCA addition
C2L64_RS14960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2L64_RS14970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2L64_RS14980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2L64_RS14980	COG0512	Glutamine amidotransferase of anthranilate synthase
C2L64_RS14985	COG0484	heat shock protein binding
C2L64_RS14990	COG0443	Heat shock 70 kDa protein
C2L64_RS15000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2L64_RS15010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2L64_RS15015	COG1420	regulation of RNA biosynthetic process
C2L64_RS15020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2L64_RS15025	COG0497	DNA recombination
C2L64_RS15030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2L64_RS15040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2L64_RS15045	COG0312	modulator of DNA gyrase
C2L64_RS15050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2L64_RS15060	COG2096	Adenosyltransferase
C2L64_RS15065	COG0277	FAD linked oxidase domain protein
C2L64_RS15070	COG0277	FAD linked oxidase domain protein
C2L64_RS15080	COG0277	FAD linked oxidase domain protein
C2L64_RS15085	COG0247	lactate metabolic process
C2L64_RS15100	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C2L64_RS15105	COG0783	Belongs to the Dps family
C2L64_RS15115	COG0753	catalase activity
C2L64_RS15130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2L64_RS15135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2L64_RS15140	COG0343	queuine tRNA-ribosyltransferase activity
C2L64_RS15145	COG1862	Preprotein translocase
C2L64_RS15155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2L64_RS15170	COG2353	YceI-like domain
C2L64_RS15175	COG2353	YceI-like domain
C2L64_RS15180	COG3038	cytochrome b561
C2L64_RS15190	COG2995	paraquat-inducible protein a
C2L64_RS15195	COG3008	intermembrane lipid transfer
C2L64_RS15240	COG0482	sulfurtransferase activity
C2L64_RS15245	COG0069	glutamate synthase activity
C2L64_RS15250	COG0501	Belongs to the peptidase M48B family
C2L64_RS15255	COG0625	glutathione transferase activity
C2L64_RS15265	COG0006	proline dipeptidase activity
C2L64_RS15270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS15280	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C2L64_RS15285	COG0138	bifunctional purine biosynthesis protein purh
C2L64_RS15290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2L64_RS15300	COG0632	four-way junction helicase activity
C2L64_RS15305	COG2255	four-way junction helicase activity
C2L64_RS15310	COG0406	alpha-ribazole phosphatase activity
C2L64_RS15315	COG1490	D-aminoacyl-tRNA deacylase activity
C2L64_RS15325	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C2L64_RS15330	COG0316	Belongs to the HesB IscA family
C2L64_RS15335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2L64_RS15340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2L64_RS15360	COG0418	dihydroorotase activity
C2L64_RS15365	COG0121	glutamine amidotransferase
C2L64_RS15375	COG1126	abc transporter atp-binding protein
C2L64_RS15380	COG0765	amino acid transport
C2L64_RS15385	COG0765	amino acid transport
C2L64_RS15395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2L64_RS15400	COG0583	DNA-binding transcription factor activity
C2L64_RS15410	COG3265	gluconokinase activity
C2L64_RS15420	COG0800	Aldolase
C2L64_RS15435	COG5295	Hep Hag repeat protein
C2L64_RS15440	COG1981	membrane
C2L64_RS15445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2L64_RS15460	COG0495	leucyl-tRNA aminoacylation
C2L64_RS15475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2L64_RS15480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2L64_RS15485	COG0735	belongs to the Fur family
C2L64_RS15495	COG4266	Belongs to the allantoicase family
C2L64_RS15500	COG1301	dicarboxylic acid transport
C2L64_RS15510	COG3415	Transposase
C2L64_RS15510	COG2801	Transposase and inactivated derivatives
C2L64_RS15515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2L64_RS15520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2L64_RS15530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2L64_RS15540	COG4290	ribonuclease
C2L64_RS15545	COG3344	reverse transcriptase
C2L64_RS15560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2L64_RS15565	COG1546	Belongs to the CinA family
C2L64_RS15575	COG0284	orotidine-5'-phosphate decarboxylase activity
C2L64_RS15600	COG1129	ABC transporter
C2L64_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS15625	COG1414	Transcriptional regulator
C2L64_RS15635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2L64_RS15640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS15645	COG0557	exoribonuclease II activity
C2L64_RS15650	COG3150	esterase
C2L64_RS15655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2L64_RS15665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2L64_RS15670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2L64_RS15675	COG0511	ligase activity, forming carbon-carbon bonds
C2L64_RS15680	COG0439	Biotin carboxylase
C2L64_RS15685	COG2264	protein methyltransferase activity
C2L64_RS15695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2L64_RS15700	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2L64_RS15700	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2L64_RS15725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2L64_RS15725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2L64_RS15740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L64_RS15745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2L64_RS15750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2L64_RS15755	COG2095	MarC family integral membrane protein
C2L64_RS15760	COG0442	prolyl-tRNA aminoacylation
C2L64_RS15770	COG0494	nUDIX hydrolase
C2L64_RS15780	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2L64_RS15785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2L64_RS15790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2L64_RS15795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2L64_RS15800	COG0142	geranyltranstransferase activity
C2L64_RS15810	COG4536	flavin adenine dinucleotide binding
C2L64_RS15825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2L64_RS15835	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2L64_RS15840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C2L64_RS15845	COG0494	nUDIX hydrolase
C2L64_RS15860	COG0653	protein targeting
C2L64_RS15870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2L64_RS15875	COG0678	peroxiredoxin activity
C2L64_RS15895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2L64_RS15900	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2L64_RS15905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2L64_RS15910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2L64_RS15920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2L64_RS15925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2L64_RS15930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2L64_RS15935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2L64_RS15945	COG3116	cell division
C2L64_RS15950	COG0275	rRNA processing
C2L64_RS15960	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C2L64_RS15965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS15970	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS15980	COG0582	viral genome integration into host DNA
C2L64_RS15985	COG4974	Belongs to the 'phage' integrase family
C2L64_RS15990	COG0243	molybdopterin cofactor binding
C2L64_RS15995	COG1473	amidohydrolase
C2L64_RS16025	COG1024	Enoyl-CoA hydratase
C2L64_RS16035	COG0183	Belongs to the thiolase family
C2L64_RS16040	COG1024	Enoyl-CoA hydratase
C2L64_RS16045	COG2050	protein possibly involved in aromatic compounds catabolism
C2L64_RS16055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2L64_RS16060	COG2967	ApaG domain
C2L64_RS16070	COG0546	phosphoglycolate phosphatase activity
C2L64_RS16085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2L64_RS16090	COG0134	indole-3-glycerol-phosphate synthase activity
C2L64_RS16100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2L64_RS16105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS16115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2L64_RS16120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS16125	COG0012	GTP binding
C2L64_RS16145	COG0395	ABC-type sugar transport system, permease component
C2L64_RS16150	COG3842	ATPase activity
C2L64_RS16160	COG0488	(ABC) transporter
C2L64_RS16175	COG1335	isochorismatase
C2L64_RS16180	COG0006	proline dipeptidase activity
C2L64_RS16195	COG3344	reverse transcriptase
C2L64_RS16200	COG0745	RESPONSE REGULATOR receiver
C2L64_RS16205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2L64_RS16210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2L64_RS16215	COG2890	protein-(glutamine-N5) methyltransferase activity
C2L64_RS16220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2L64_RS16230	COG3384	dioxygenase
C2L64_RS16235	COG3344	reverse transcriptase
C2L64_RS16245	COG0531	amino acid
C2L64_RS16250	COG1278	Cold shock
C2L64_RS16255	COG0443	Heat shock 70 kDa protein
C2L64_RS16260	COG0477	Major facilitator Superfamily
C2L64_RS16300	COG2271	Major facilitator Superfamily
C2L64_RS16305	COG2721	sulfolactate sulfo-lyase activity
C2L64_RS16320	COG2813	Specifically methylates the guanine in position
C2L64_RS16330	COG2969	positive regulation of protein catabolic process
C2L64_RS16335	COG0625	glutathione transferase activity
C2L64_RS16340	COG2857	Cytochrome c1
C2L64_RS16345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2L64_RS16350	COG0723	plastoquinol--plastocyanin reductase activity
C2L64_RS16355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2L64_RS16360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS16365	COG0805	protein transport
C2L64_RS16370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2L64_RS16375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2L64_RS16390	COG0140	phosphoribosyl-ATP diphosphatase activity
C2L64_RS16395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2L64_RS16400	COG0107	imidazoleglycerol-phosphate synthase activity
C2L64_RS16405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2L64_RS16415	COG2095	MarC family integral membrane protein
C2L64_RS16420	COG0131	Imidazoleglycerol-phosphate dehydratase
C2L64_RS16425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2L64_RS16440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2L64_RS16450	COG0842	Transport permease protein
C2L64_RS16455	COG1131	(ABC) transporter
C2L64_RS16470	COG2853	Lipoprotein
C2L64_RS16475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L64_RS16480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2L64_RS16485	COG1127	ABC transporter
C2L64_RS16510	COG4178	(ABC) transporter
C2L64_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS16535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C2L64_RS16575	COG2814	Major facilitator Superfamily
C2L64_RS16580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS16600	COG0067	glutamate synthase
C2L64_RS16600	COG0069	glutamate synthase activity
C2L64_RS16600	COG0070	glutamate synthase
C2L64_RS16620	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C2L64_RS16625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2L64_RS16660	COG1965	Belongs to the frataxin family
C2L64_RS16670	COG0019	diaminopimelate decarboxylase activity
C2L64_RS16675	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2L64_RS16680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L64_RS16685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L64_RS16690	COG1333	cytochrome c biogenesis protein
C2L64_RS16700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2L64_RS16710	COG4232	protein-disulfide reductase activity
C2L64_RS16720	COG0203	ribosomal protein L17
C2L64_RS16725	COG0202	RNA polymerase activity
C2L64_RS16730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2L64_RS16735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2L64_RS16740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2L64_RS16755	COG0201	protein transport
C2L64_RS16760	COG0200	Binds to the 23S rRNA
C2L64_RS16770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2L64_RS16775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2L64_RS16780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2L64_RS16785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2L64_RS16790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2L64_RS16795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2L64_RS16800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2L64_RS16805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2L64_RS16815	COG0255	Belongs to the universal ribosomal protein uL29 family
C2L64_RS16820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2L64_RS16825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2L64_RS16830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2L64_RS16835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2L64_RS16840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2L64_RS16845	COG0089	rRNA binding
C2L64_RS16850	COG0088	Forms part of the polypeptide exit tunnel
C2L64_RS16855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2L64_RS16860	COG0051	transcription antitermination factor activity, RNA binding
C2L64_RS16865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2L64_RS16870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2L64_RS16875	COG0049	tRNA binding
C2L64_RS16880	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2L64_RS16885	COG0514	ATP-dependent DNA helicase (RecQ)
C2L64_RS16890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2L64_RS16895	COG0085	RNA polymerase activity
C2L64_RS16900	COG0222	ribosome binding
C2L64_RS16905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2L64_RS16910	COG0081	regulation of translation
C2L64_RS16915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2L64_RS16925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2L64_RS16935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2L64_RS16985	COG3396	Phenylacetate-CoA oxygenase
C2L64_RS16990	COG3460	Phenylacetate-CoA oxygenase
C2L64_RS16995	COG3396	Phenylacetate-CoA oxygenase
C2L64_RS17000	COG2151	metal-sulfur cluster biosynthetic enzyme
C2L64_RS17005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS17025	COG1522	sequence-specific DNA binding
C2L64_RS17045	COG0281	malic enzyme
C2L64_RS17045	COG0280	phosphate acetyltransferase
C2L64_RS17050	COG2814	Major facilitator Superfamily
C2L64_RS17055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2L64_RS17065	COG1881	PFAM PEBP family protein
C2L64_RS17075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2L64_RS17090	COG3047	cAMP biosynthetic process
C2L64_RS17095	COG0583	DNA-binding transcription factor activity
C2L64_RS17100	COG2814	Major facilitator Superfamily
C2L64_RS17105	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS17110	COG2084	Dehydrogenase
C2L64_RS17150	COG5001	Diguanylate cyclase
C2L64_RS17150	COG4251	negative regulation of phosphorylation
C2L64_RS17150	COG3706	GGDEF domain
C2L64_RS17150	COG2203	Gaf domain
C2L64_RS17170	COG0673	inositol 2-dehydrogenase activity
C2L64_RS17180	COG2226	methyltransferase
C2L64_RS17185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2L64_RS17190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2L64_RS17195	COG0037	tRNA processing
C2L64_RS17205	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS17220	COG0617	tRNA 3'-terminal CCA addition
C2L64_RS17235	COG0741	lytic transglycosylase activity
C2L64_RS17240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2L64_RS17255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2L64_RS17260	COG1984	allophanate hydrolase subunit 2
C2L64_RS17265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2L64_RS17290	COG4608	Belongs to the ABC transporter superfamily
C2L64_RS17295	COG0444	Belongs to the ABC transporter superfamily
C2L64_RS17300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS17305	COG0601	transmembrane transport
C2L64_RS17310	COG0747	negative chemotaxis
C2L64_RS17315	COG0747	negative chemotaxis
C2L64_RS17320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2L64_RS17325	COG1950	PFAM Membrane protein of
C2L64_RS17330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2L64_RS17335	COG1215	transferase activity, transferring glycosyl groups
C2L64_RS17345	COG1380	Effector of murein hydrolase LrgA
C2L64_RS17350	COG0583	DNA-binding transcription factor activity
C2L64_RS17365	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS17375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2L64_RS17390	COG1516	flagellar protein fliS
C2L64_RS17415	COG1157	protein secretion by the type III secretion system
C2L64_RS17445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2L64_RS17455	COG1338	Plays a role in the flagellum-specific transport system
C2L64_RS17475	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS17480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2L64_RS17485	COG1256	bacterial-type flagellum assembly
C2L64_RS17495	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2L64_RS17505	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2L64_RS17505	COG3951	Flagellar rod assembly protein muramidase FlgJ
C2L64_RS17510	COG1706	bacterial-type flagellum-dependent cell motility
C2L64_RS17525	COG4787	bacterial-type flagellum-dependent cell motility
C2L64_RS17530	COG1749	Flagellar hook protein flgE
C2L64_RS17535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2L64_RS17540	COG1558	bacterial-type flagellum-dependent cell motility
C2L64_RS17565	COG1191	sigma factor activity
C2L64_RS17580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2L64_RS17585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2L64_RS17600	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS17605	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2L64_RS17610	COG0745	RESPONSE REGULATOR receiver
C2L64_RS17615	COG2201	protein-glutamate methylesterase activity
C2L64_RS17620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2L64_RS17630	COG0840	transmembrane signaling receptor activity
C2L64_RS17645	COG2201	protein-glutamate methylesterase activity
C2L64_RS17650	COG1360	Flagellar Motor Protein
C2L64_RS17670	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS17680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2L64_RS17690	COG0561	phosphatase activity
C2L64_RS17700	COG2818	Glycosylase
C2L64_RS17710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2L64_RS17715	COG0667	Aldo Keto reductase
C2L64_RS17745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2L64_RS17780	COG0210	DNA helicase
C2L64_RS17785	COG0673	inositol 2-dehydrogenase activity
C2L64_RS17795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2L64_RS17800	COG0509	glycine decarboxylation via glycine cleavage system
C2L64_RS17805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2L64_RS17805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2L64_RS17810	COG4106	trans-aconitate 2-methyltransferase activity
C2L64_RS17820	COG2089	acid synthase
C2L64_RS17825	COG1083	cytidylyl-transferase
C2L64_RS17830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2L64_RS17835	COG1086	Polysaccharide biosynthesis protein
C2L64_RS17855	COG1760	l-serine dehydratase
C2L64_RS17860	COG0028	Belongs to the TPP enzyme family
C2L64_RS17865	COG0683	leucine binding
C2L64_RS17870	COG0506	proline dehydrogenase activity
C2L64_RS17870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2L64_RS17870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2L64_RS17880	COG2855	membrane
C2L64_RS17885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2L64_RS17890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2L64_RS17905	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS17910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2L64_RS17920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2L64_RS17925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2L64_RS17930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2L64_RS17935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2L64_RS17945	COG0356	it plays a direct role in the translocation of protons across the membrane
C2L64_RS17955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2L64_RS17960	COG1475	DNA binding
C2L64_RS17965	COG1192	Involved in chromosome partitioning
C2L64_RS17970	COG0357	Ribosomal RNA small subunit methyltransferase G
C2L64_RS17975	COG0445	tRNA wobble uridine modification
C2L64_RS17995	COG0683	leucine binding
C2L64_RS18030	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2L64_RS18040	COG0583	DNA-binding transcription factor activity
C2L64_RS18055	COG3186	Phenylalanine-4-hydroxylase
C2L64_RS18060	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2L64_RS18075	COG0642	Histidine kinase
C2L64_RS18085	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS18090	COG2258	MOSC domain
C2L64_RS18095	COG0505	Belongs to the CarA family
C2L64_RS18105	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C2L64_RS18120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2L64_RS18120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS18130	COG0523	cobalamin synthesis protein
C2L64_RS18165	COG2165	general secretion pathway protein
C2L64_RS18230	COG2169	Transcriptional regulator
C2L64_RS18230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2L64_RS18255	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS18270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2L64_RS18280	COG0706	membrane insertase activity
C2L64_RS18285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2L64_RS18290	COG0594	ribonuclease P activity
C2L64_RS18315	COG1393	Belongs to the ArsC family
C2L64_RS18320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS18325	COG3813	Protein conserved in bacteria
C2L64_RS18345	COG3437	response regulator, receiver
C2L64_RS18365	COG1562	ergosterol biosynthetic process
C2L64_RS18370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2L64_RS18375	COG1657	PFAM Prenyltransferase squalene oxidase
C2L64_RS18390	COG2853	Lipoprotein
C2L64_RS18405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2L64_RS18430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS18435	COG1254	Belongs to the acylphosphatase family
C2L64_RS18440	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C2L64_RS18460	COG0859	PFAM glycosyl transferase family 9
C2L64_RS18460	COG0457	Tetratricopeptide repeat
C2L64_RS18480	COG1592	Rubrerythrin
C2L64_RS18485	COG0247	lactate metabolic process
C2L64_RS18515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS18520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2L64_RS18535	COG0435	Glutathione S-transferase
C2L64_RS18540	COG0583	DNA-binding transcription factor activity
C2L64_RS18545	COG3038	cytochrome b561
C2L64_RS18565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS18575	COG3795	YCII-related domain
C2L64_RS18580	COG3795	YCII-related domain
C2L64_RS18590	COG4941	Belongs to the sigma-70 factor family
C2L64_RS18600	COG1063	alcohol dehydrogenase
C2L64_RS18615	COG2207	Transcriptional regulator
C2L64_RS18675	COG2336	PFAM SpoVT AbrB
C2L64_RS18700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L64_RS18745	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS18750	COG1024	Enoyl-CoA hydratase
C2L64_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS18770	COG2814	Major facilitator Superfamily
C2L64_RS18775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS18795	COG4774	siderophore transport
C2L64_RS18800	COG3712	iron ion homeostasis
C2L64_RS18805	COG1595	DNA-templated transcription, initiation
C2L64_RS18825	COG0583	DNA-binding transcription factor activity
C2L64_RS18830	COG0183	Belongs to the thiolase family
C2L64_RS18835	COG0477	Major facilitator Superfamily
C2L64_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS18845	COG1024	Enoyl-CoA hydratase
C2L64_RS18850	COG0583	DNA-binding transcription factor activity
C2L64_RS18855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS18865	COG2207	Transcriptional regulator
C2L64_RS18865	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS18910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS18915	COG0395	ABC-type sugar transport system, permease component
C2L64_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS18940	COG1737	Transcriptional regulator
C2L64_RS18985	COG2175	clavaminate synthase activity
C2L64_RS18990	COG1120	ATPase activity
C2L64_RS19030	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C2L64_RS19035	COG4774	siderophore transport
C2L64_RS19045	COG1522	sequence-specific DNA binding
C2L64_RS19050	COG1953	Uracil, thiamine, allantoin
C2L64_RS19060	COG1959	2 iron, 2 sulfur cluster binding
C2L64_RS19065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS19120	COG1846	Transcriptional regulator
C2L64_RS19125	COG1846	Transcriptional regulator
C2L64_RS19135	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS19140	COG2814	Major facilitator Superfamily
C2L64_RS19170	COG2823	Periplasmic or secreted lipoprotein
C2L64_RS19185	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS19190	COG1053	succinate dehydrogenase
C2L64_RS19210	COG0444	Belongs to the ABC transporter superfamily
C2L64_RS19215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS19220	COG0601	transmembrane transport
C2L64_RS19230	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C2L64_RS19240	COG0753	catalase activity
C2L64_RS19245	COG0583	DNA-binding transcription factor activity
C2L64_RS19250	COG1956	GAF domain-containing protein
C2L64_RS19265	COG0730	response to heat
C2L64_RS19280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2L64_RS19285	COG0745	RESPONSE REGULATOR receiver
C2L64_RS19295	COG0840	transmembrane signaling receptor activity
C2L64_RS19315	COG0545	Peptidyl-prolyl cis-trans isomerase
C2L64_RS19340	COG0432	Pfam Uncharacterised protein family UPF0047
C2L64_RS19350	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS19360	COG0251	oxidation-reduction process
C2L64_RS19365	COG3133	Outer membrane lipoprotein
C2L64_RS19380	COG4770	biotin carboxylase activity
C2L64_RS19395	COG1116	anion transmembrane transporter activity
C2L64_RS19410	COG0583	DNA-binding transcription factor activity
C2L64_RS19415	COG0477	Major facilitator Superfamily
C2L64_RS19440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2L64_RS19465	COG0735	belongs to the Fur family
C2L64_RS19475	COG0642	Histidine kinase
C2L64_RS19490	COG0569	domain protein
C2L64_RS19490	COG2985	domain, Protein
C2L64_RS19495	COG3300	MHYT domain
C2L64_RS19495	COG5001	Diguanylate cyclase
C2L64_RS19500	COG1522	sequence-specific DNA binding
C2L64_RS19510	COG2186	Transcriptional regulator
C2L64_RS19515	COG2084	Dehydrogenase
C2L64_RS19520	COG3395	kinase activity
C2L64_RS19525	COG0235	Class ii aldolase
C2L64_RS19530	COG2271	Major facilitator Superfamily
C2L64_RS19535	COG3622	Belongs to the hyi family
C2L64_RS19540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS19550	COG2207	Transcriptional regulator
C2L64_RS19585	COG0523	cobalamin synthesis protein
C2L64_RS19590	COG0252	asparaginase activity
C2L64_RS19600	COG1301	dicarboxylic acid transport
C2L64_RS19605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2L64_RS19615	COG1301	dicarboxylic acid transport
C2L64_RS19630	COG0583	DNA-binding transcription factor activity
C2L64_RS19635	COG0517	IMP dehydrogenase activity
C2L64_RS19650	COG1301	dicarboxylic acid transport
C2L64_RS19655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2L64_RS19660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS19665	COG0589	response to stress
C2L64_RS19670	COG2186	Transcriptional regulator
C2L64_RS19675	COG0477	Major facilitator Superfamily
C2L64_RS19715	COG3842	ATPase activity
C2L64_RS19720	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS19755	COG1045	serine acetyltransferase
C2L64_RS19770	COG0302	gtp cyclohydrolase
C2L64_RS19790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2L64_RS19800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS19805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS19840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2L64_RS19845	COG0436	Aminotransferase
C2L64_RS19880	COG0346	lactoylglutathione lyase activity
C2L64_RS19900	COG3706	GGDEF domain
C2L64_RS19900	COG2203	Gaf domain
C2L64_RS19900	COG5001	Diguanylate cyclase
C2L64_RS19900	COG4251	negative regulation of phosphorylation
C2L64_RS19905	COG0583	DNA-binding transcription factor activity
C2L64_RS19910	COG0625	glutathione transferase activity
C2L64_RS19915	COG1017	nitric oxide dioxygenase activity
C2L64_RS19915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS19925	COG1595	DNA-templated transcription, initiation
C2L64_RS19950	COG3620	sequence-specific DNA binding
C2L64_RS19950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2L64_RS19950	COG0617	tRNA 3'-terminal CCA addition
C2L64_RS19995	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS20010	COG0183	Belongs to the thiolase family
C2L64_RS20015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS20035	COG0444	Belongs to the ABC transporter superfamily
C2L64_RS20040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS20045	COG0601	transmembrane transport
C2L64_RS20050	COG4166	transmembrane transport
C2L64_RS20065	COG3104	oligopeptide transport
C2L64_RS20085	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS20090	COG2308	Evidence 4 Homologs of previously reported genes of
C2L64_RS20110	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS20115	COG1295	ribonuclease BN
C2L64_RS20120	COG0243	molybdopterin cofactor binding
C2L64_RS20120	COG3383	formate dehydrogenase (NAD+) activity
C2L64_RS20125	COG3383	formate dehydrogenase (NAD+) activity
C2L64_RS20125	COG0243	molybdopterin cofactor binding
C2L64_RS20130	COG0437	4 iron, 4 sulfur cluster binding
C2L64_RS20135	COG2864	formate dehydrogenase
C2L64_RS20145	COG1921	L-seryl-tRNASec selenium transferase activity
C2L64_RS20150	COG3276	selenocysteine insertion sequence binding
C2L64_RS20205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2L64_RS20345	COG0741	lytic transglycosylase activity
C2L64_RS20365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2L64_RS20480	COG1063	alcohol dehydrogenase
C2L64_RS20490	COG0523	cobalamin synthesis protein
C2L64_RS20505	COG3350	monooxygenase activity
C2L64_RS20510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS20535	COG0459	protein refolding
C2L64_RS20545	COG1914	H( )-stimulated, divalent metal cation uptake system
C2L64_RS20610	COG3328	transposase activity
C2L64_RS20615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS20625	COG0174	glutamine synthetase
C2L64_RS20635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2L64_RS20685	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2L64_RS20715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2L64_RS20755	COG2186	Transcriptional regulator
C2L64_RS20765	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS20770	COG4213	ABC transporter substrate-binding protein
C2L64_RS20780	COG1063	alcohol dehydrogenase
C2L64_RS20800	COG0702	epimerase
C2L64_RS20845	COG0596	Alpha beta hydrolase
C2L64_RS20855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS20865	COG0583	DNA-binding transcription factor activity
C2L64_RS20870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS20875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS20880	COG0765	amino acid transport
C2L64_RS20885	COG0765	amino acid transport
C2L64_RS20890	COG1126	abc transporter atp-binding protein
C2L64_RS20920	COG1063	alcohol dehydrogenase
C2L64_RS20930	COG3842	ATPase activity
C2L64_RS20945	COG0395	ABC-type sugar transport system, permease component
C2L64_RS20950	COG1874	Beta-galactosidase
C2L64_RS20975	COG1414	Transcriptional regulator
C2L64_RS20980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2L64_RS20985	COG0066	3-isopropylmalate dehydratase activity
C2L64_RS20990	COG0473	3-isopropylmalate dehydrogenase activity
C2L64_RS21005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS21015	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS21020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS21040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS21045	COG2188	Transcriptional regulator
C2L64_RS21075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2L64_RS21080	COG0066	3-isopropylmalate dehydratase activity
C2L64_RS21095	COG1335	isochorismatase
C2L64_RS21105	COG2721	sulfolactate sulfo-lyase activity
C2L64_RS21125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS21130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS21135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS21140	COG0372	Belongs to the citrate synthase family
C2L64_RS21145	COG2814	Major facilitator Superfamily
C2L64_RS21145	COG0477	Major facilitator Superfamily
C2L64_RS21175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS21185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2L64_RS21215	COG3052	prosthetic group binding
C2L64_RS21220	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C2L64_RS21230	COG0243	molybdopterin cofactor binding
C2L64_RS21235	COG0437	4 iron, 4 sulfur cluster binding
C2L64_RS21240	COG3302	dmso reductase anchor subunit
C2L64_RS21250	COG1231	oxidoreductase activity
C2L64_RS21255	COG1966	Carbon starvation protein
C2L64_RS21285	COG1764	response to oxidative stress
C2L64_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS21320	COG0583	DNA-binding transcription factor activity
C2L64_RS21345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS21360	COG3454	Phosphonate metabolism
C2L64_RS21365	COG4778	phosphonate C-P lyase system protein PhnL
C2L64_RS21370	COG4107	phosphonate C-P lyase system protein PhnK
C2L64_RS21375	COG3627	carbon phosphorus lyase activity
C2L64_RS21380	COG3626	phosphonate metabolism
C2L64_RS21385	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C2L64_RS21390	COG3624	Phosphonate C-P lyase system protein PhnG
C2L64_RS21395	COG2188	Transcriptional regulator
C2L64_RS21405	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2L64_RS21410	COG1473	amidohydrolase
C2L64_RS21415	COG1414	Transcriptional regulator
C2L64_RS21435	COG2378	regulation of single-species biofilm formation
C2L64_RS21440	COG3284	Transcriptional regulator
C2L64_RS21445	COG3199	ATP-NAD kinase
C2L64_RS21450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2L64_RS21455	COG0022	dehydrogenase e1 component
C2L64_RS21465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2L64_RS21475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2L64_RS21490	COG3639	organic phosphonate transmembrane transporter activity
C2L64_RS21495	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2L64_RS21500	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2L64_RS21510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS21510	COG2226	methyltransferase
C2L64_RS21510	COG0596	Alpha beta hydrolase
C2L64_RS21545	COG2902	Dehydrogenase
C2L64_RS21570	COG0583	DNA-binding transcription factor activity
C2L64_RS21580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS21595	COG1914	H( )-stimulated, divalent metal cation uptake system
C2L64_RS21610	COG2391	methyltransferase activity
C2L64_RS21640	COG2197	response regulator
C2L64_RS21645	COG1396	sequence-specific DNA binding
C2L64_RS21665	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L64_RS21665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2L64_RS21675	COG0174	glutamine synthetase
C2L64_RS21680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2L64_RS21685	COG2218	PFAM glutamate synthase alpha subunit domain protein
C2L64_RS21690	COG0069	glutamate synthase activity
C2L64_RS21695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2L64_RS21700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2L64_RS21700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2L64_RS21710	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2L64_RS21715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2L64_RS21720	COG0045	succinate-CoA ligase (ADP-forming) activity
C2L64_RS21725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS21730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L64_RS21735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2L64_RS21750	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
C2L64_RS21755	COG1229	Formylmethanofuran dehydrogenase subunit A
C2L64_RS21800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2L64_RS21815	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
C2L64_RS21820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2L64_RS21825	COG0702	epimerase
C2L64_RS21835	COG0583	DNA-binding transcription factor activity
C2L64_RS21845	COG3954	Phosphoribulokinase
C2L64_RS21850	COG0546	phosphoglycolate phosphatase activity
C2L64_RS21855	COG3284	Transcriptional regulator
C2L64_RS21860	COG2197	response regulator
C2L64_RS21880	COG0247	lactate metabolic process
C2L64_RS21880	COG2181	nitrate reductase activity
C2L64_RS21890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2L64_RS21915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS21920	COG3850	Histidine kinase
C2L64_RS21940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2L64_RS21955	COG0531	amino acid
C2L64_RS21970	COG0454	-acetyltransferase
C2L64_RS21970	COG0456	acetyltransferase
C2L64_RS22015	COG1024	Enoyl-CoA hydratase
C2L64_RS22025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS22050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS22055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS22065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS22070	COG1609	Transcriptional regulator
C2L64_RS22075	COG1414	Transcriptional regulator
C2L64_RS22085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2L64_RS22090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2L64_RS22095	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS22105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L64_RS22110	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS22115	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS22130	COG1349	DNA-binding transcription factor activity
C2L64_RS22135	COG2259	Doxx family
C2L64_RS22150	COG0477	Major facilitator Superfamily
C2L64_RS22160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS22165	COG3938	Belongs to the proline racemase family
C2L64_RS22205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2L64_RS22215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS22225	COG1940	carbohydrate kinase activity
C2L64_RS22255	COG0840	transmembrane signaling receptor activity
C2L64_RS22265	COG0745	RESPONSE REGULATOR receiver
C2L64_RS22285	COG0583	DNA-binding transcription factor activity
C2L64_RS22290	COG0477	Major facilitator Superfamily
C2L64_RS22295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS22310	COG3588	fructose-bisphosphate aldolase
C2L64_RS22315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2L64_RS22335	COG0659	secondary active sulfate transmembrane transporter activity
C2L64_RS22340	COG2271	Major facilitator Superfamily
C2L64_RS22350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS22355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS22365	COG1177	transmembrane transport
C2L64_RS22370	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS22375	COG3842	ATPase activity
C2L64_RS22390	COG0174	glutamine synthetase
C2L64_RS22395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2L64_RS22395	COG0519	Catalyzes the synthesis of GMP from XMP
C2L64_RS22405	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS22405	COG1396	sequence-specific DNA binding
C2L64_RS22410	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS22435	COG0583	DNA-binding transcription factor activity
C2L64_RS22450	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS22455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2L64_RS22460	COG1024	Enoyl-CoA hydratase
C2L64_RS22475	COG0859	PFAM glycosyl transferase family 9
C2L64_RS22485	COG2134	cdp-diacylglycerol pyrophosphatase
C2L64_RS22505	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2L64_RS22515	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS22520	COG2271	Major facilitator Superfamily
C2L64_RS22525	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS22530	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS22535	COG0583	DNA-binding transcription factor activity
C2L64_RS22540	COG3254	rhamnose metabolic process
C2L64_RS22545	COG3618	amidohydrolase
C2L64_RS22550	COG1129	ABC transporter
C2L64_RS22555	COG4211	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS22565	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS22570	COG2197	response regulator
C2L64_RS22610	COG1116	anion transmembrane transporter activity
C2L64_RS22610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS22615	COG3707	response regulator
C2L64_RS22620	COG2807	transmembrane transport
C2L64_RS22630	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2L64_RS22665	COG0583	DNA-binding transcription factor activity
C2L64_RS22675	COG0840	transmembrane signaling receptor activity
C2L64_RS22715	COG3284	Transcriptional regulator
C2L64_RS22730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS22735	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2L64_RS22740	COG2080	2 iron, 2 sulfur cluster binding
C2L64_RS22745	COG0540	Belongs to the ATCase OTCase family
C2L64_RS22750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS22755	COG0739	heme binding
C2L64_RS22800	COG2974	May be involved in recombination
C2L64_RS22810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS22835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS22860	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS22890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS22905	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS22915	COG0058	SHG alpha-glucan phosphorylase activity
C2L64_RS22935	COG1175	transmembrane transport
C2L64_RS22940	COG0395	ABC-type sugar transport system, permease component
C2L64_RS22950	COG3842	ATPase activity
C2L64_RS22960	COG1461	Dihydroxyacetone kinase
C2L64_RS22965	COG2376	Dihydroxyacetone kinase
C2L64_RS22975	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS22985	COG3842	ATPase activity
C2L64_RS22995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L64_RS23005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L64_RS23015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C2L64_RS23060	COG4977	sequence-specific DNA binding
C2L64_RS23070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2L64_RS23080	COG0477	Major facilitator Superfamily
C2L64_RS23120	COG0642	Histidine kinase
C2L64_RS23150	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2L64_RS23160	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS23165	COG1129	ABC transporter
C2L64_RS23170	COG2814	Major facilitator Superfamily
C2L64_RS23180	COG1695	Transcriptional regulator
C2L64_RS23215	COG4191	Histidine kinase
C2L64_RS23225	COG4566	intracellular signal transduction
C2L64_RS23235	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L64_RS23260	COG0596	Alpha beta hydrolase
C2L64_RS23280	COG0583	DNA-binding transcription factor activity
C2L64_RS23290	COG4566	intracellular signal transduction
C2L64_RS23325	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS23445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS23455	COG1802	Transcriptional regulator
C2L64_RS23465	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS23495	COG1846	Transcriptional regulator
C2L64_RS23505	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS23515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L64_RS23520	COG2223	nitrite transmembrane transporter activity
C2L64_RS23540	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS23545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS23550	COG0778	Nitroreductase
C2L64_RS23585	COG0583	DNA-binding transcription factor activity
C2L64_RS23590	COG0583	DNA-binding transcription factor activity
C2L64_RS23600	COG1741	Belongs to the pirin family
C2L64_RS23605	COG2259	Doxx family
C2L64_RS23635	COG1053	succinate dehydrogenase
C2L64_RS23645	COG1846	Transcriptional regulator
C2L64_RS23655	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2L64_RS23705	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS23730	COG1846	Transcriptional regulator
C2L64_RS23755	COG1414	Transcriptional regulator
C2L64_RS23760	COG1414	Transcriptional regulator
C2L64_RS23785	COG1129	ABC transporter
C2L64_RS23790	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS23810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2L64_RS23815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS23820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS23830	COG0346	lactoylglutathione lyase activity
C2L64_RS23835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS23840	COG0697	spore germination
C2L64_RS23855	COG2207	Transcriptional regulator
C2L64_RS23860	COG2814	Major facilitator Superfamily
C2L64_RS23865	COG0400	carboxylic ester hydrolase activity
C2L64_RS23870	COG1077	Cell shape determining protein MreB Mrl
C2L64_RS23885	COG0372	Belongs to the citrate synthase family
C2L64_RS23890	COG2801	Transposase and inactivated derivatives
C2L64_RS23890	COG3415	Transposase
C2L64_RS23915	COG1802	Transcriptional regulator
C2L64_RS23920	COG0745	RESPONSE REGULATOR receiver
C2L64_RS23935	COG0745	RESPONSE REGULATOR receiver
C2L64_RS23980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS23985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS24010	COG0583	DNA-binding transcription factor activity
C2L64_RS24030	COG0477	Major facilitator Superfamily
C2L64_RS24040	COG1538	Outer membrane efflux protein
C2L64_RS24050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS24060	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2L64_RS24090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2L64_RS24105	COG1764	response to oxidative stress
C2L64_RS24140	COG1132	(ABC) transporter
C2L64_RS24145	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2L64_RS24150	COG2030	dehydratase
C2L64_RS24160	COG3246	L-lysine catabolic process to acetate
C2L64_RS24175	COG2175	clavaminate synthase activity
C2L64_RS24185	COG2146	nitrite reductase [NAD(P)H] activity
C2L64_RS24200	COG2823	Periplasmic or secreted lipoprotein
C2L64_RS24205	COG3447	MASE1 domain protein
C2L64_RS24205	COG5002	protein histidine kinase activity
C2L64_RS24205	COG5001	Diguanylate cyclase
C2L64_RS24210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2L64_RS24235	COG3064	Membrane
C2L64_RS24240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS24245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2L64_RS24250	COG3064	Membrane
C2L64_RS24270	COG0668	transmembrane transport
C2L64_RS24285	COG3485	protocatechuate 3,4-dioxygenase
C2L64_RS24295	COG2084	Dehydrogenase
C2L64_RS24300	COG1063	alcohol dehydrogenase
C2L64_RS24310	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS24315	COG1129	ABC transporter
C2L64_RS24320	COG4213	ABC transporter substrate-binding protein
C2L64_RS24330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C2L64_RS24335	COG0656	L-ascorbic acid biosynthetic process
C2L64_RS24340	COG1017	nitric oxide dioxygenase activity
C2L64_RS24340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS24350	COG0628	permease
C2L64_RS24360	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS24385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS24390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2L64_RS24400	COG0384	phenazine biosynthesis protein PhzF
C2L64_RS24415	COG2319	Wd-40 repeat
C2L64_RS24415	COG4249	Peptidase C14 caspase catalytic subunit p20
C2L64_RS24435	COG1802	Transcriptional regulator
C2L64_RS24440	COG1802	Transcriptional regulator
C2L64_RS24445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS24455	COG4160	amino acid transport
C2L64_RS24465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2L64_RS24480	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS24485	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS24495	COG0583	DNA-binding transcription factor activity
C2L64_RS24505	COG2130	NADP-dependent
C2L64_RS24515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS24535	COG1024	Enoyl-CoA hydratase
C2L64_RS24575	COG1301	dicarboxylic acid transport
C2L64_RS24585	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C2L64_RS24595	COG0583	DNA-binding transcription factor activity
C2L64_RS24610	COG1017	nitric oxide dioxygenase activity
C2L64_RS24610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS24645	COG0477	Major facilitator Superfamily
C2L64_RS24655	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS24665	COG1733	regulation of RNA biosynthetic process
C2L64_RS24670	COG0596	Alpha beta hydrolase
C2L64_RS24680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2L64_RS24685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2L64_RS24690	COG1024	Enoyl-CoA hydratase
C2L64_RS24695	COG5001	Diguanylate cyclase
C2L64_RS24705	COG1201	RNA secondary structure unwinding
C2L64_RS24710	COG0667	Aldo Keto reductase
C2L64_RS24810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2L64_RS24830	COG3209	COG3209 Rhs family protein
C2L64_RS24850	COG3209	COG3209 Rhs family protein
C2L64_RS24865	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS24880	COG0477	Major facilitator Superfamily
C2L64_RS24900	COG0668	transmembrane transport
C2L64_RS24910	COG0477	Major facilitator Superfamily
C2L64_RS24945	COG4964	Belongs to the GSP D family
C2L64_RS25020	COG0745	RESPONSE REGULATOR receiver
C2L64_RS25025	COG5002	protein histidine kinase activity
C2L64_RS25025	COG2198	Histidine kinase
C2L64_RS25025	COG0784	Response regulator, receiver
C2L64_RS25030	COG0784	Response regulator, receiver
C2L64_RS25035	COG4251	negative regulation of phosphorylation
C2L64_RS25045	COG0297	glycogen (starch) synthase activity
C2L64_RS25055	COG0745	RESPONSE REGULATOR receiver
C2L64_RS25060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2L64_RS25070	COG3511	phospholipase C
C2L64_RS25090	COG2197	response regulator
C2L64_RS25095	COG0628	permease
C2L64_RS25110	COG4221	oxidoreductase activity
C2L64_RS25115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS25125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L64_RS25130	COG2181	nitrate reductase activity
C2L64_RS25135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2L64_RS25140	COG1140	nitrate reductase beta subunit
C2L64_RS25145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2L64_RS25150	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS25160	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS25160	COG4977	sequence-specific DNA binding
C2L64_RS25170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2L64_RS25190	COG3132	Protein of unknown function, DUF480
C2L64_RS25235	COG3842	ATPase activity
C2L64_RS25240	COG3842	ATPase activity
C2L64_RS25265	COG4774	siderophore transport
C2L64_RS25270	COG3128	pkhd-type hydroxylase
C2L64_RS25285	COG1620	l-lactate permease
C2L64_RS25290	COG1139	Iron-sulfur cluster binding protein
C2L64_RS25300	COG0247	lactate metabolic process
C2L64_RS25305	COG2186	Transcriptional regulator
C2L64_RS25310	COG0840	transmembrane signaling receptor activity
C2L64_RS25320	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS25340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS25350	COG1609	Transcriptional regulator
C2L64_RS25375	COG4251	negative regulation of phosphorylation
C2L64_RS25375	COG5001	Diguanylate cyclase
C2L64_RS25375	COG2203	Gaf domain
C2L64_RS25375	COG3706	GGDEF domain
C2L64_RS25405	COG0840	transmembrane signaling receptor activity
C2L64_RS25410	COG0477	Major facilitator Superfamily
C2L64_RS25415	COG0745	RESPONSE REGULATOR receiver
C2L64_RS25425	COG0583	DNA-binding transcription factor activity
C2L64_RS25460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS25470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS25475	COG2271	Major facilitator Superfamily
C2L64_RS25480	COG3622	Belongs to the hyi family
C2L64_RS25495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2L64_RS25500	COG1522	sequence-specific DNA binding
C2L64_RS25505	COG4191	Histidine kinase
C2L64_RS25505	COG0784	Response regulator, receiver
C2L64_RS25540	COG1309	transcriptional regulator
C2L64_RS25550	COG0251	oxidation-reduction process
C2L64_RS25560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2L64_RS25570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2L64_RS25575	COG0745	RESPONSE REGULATOR receiver
C2L64_RS25580	COG5002	protein histidine kinase activity
C2L64_RS25590	COG3300	MHYT domain
C2L64_RS25590	COG5001	Diguanylate cyclase
C2L64_RS25605	COG2723	6-phospho-beta-galactosidase activity
C2L64_RS25615	COG1175	transmembrane transport
C2L64_RS25625	COG3842	ATPase activity
C2L64_RS25630	COG1609	Transcriptional regulator
C2L64_RS25640	COG2801	Transposase and inactivated derivatives
C2L64_RS25640	COG3415	Transposase
C2L64_RS25670	COG3118	belongs to the thioredoxin family
C2L64_RS25685	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS25690	COG0583	DNA-binding transcription factor activity
C2L64_RS25695	COG1448	Aminotransferase
C2L64_RS25705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS25710	COG2124	cytochrome p450
C2L64_RS25720	COG5265	(ABC) transporter
C2L64_RS25725	COG1562	ergosterol biosynthetic process
C2L64_RS25770	COG0596	Alpha beta hydrolase
C2L64_RS25780	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS25800	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2L64_RS25805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS25815	COG0154	amidase activity
C2L64_RS25850	COG0583	DNA-binding transcription factor activity
C2L64_RS25860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2L64_RS25865	COG0583	DNA-binding transcription factor activity
C2L64_RS25875	COG1309	transcriptional regulator
C2L64_RS25910	COG1366	Belongs to the anti-sigma-factor antagonist family
C2L64_RS25930	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS25935	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS25940	COG1129	ABC transporter
C2L64_RS25945	COG1869	D-ribose catabolic process
C2L64_RS25950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2L64_RS26000	COG0604	alcohol dehydrogenase
C2L64_RS26005	COG1733	regulation of RNA biosynthetic process
C2L64_RS26025	COG1024	Enoyl-CoA hydratase
C2L64_RS26030	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C2L64_RS26060	COG3038	cytochrome b561
C2L64_RS26070	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS26075	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2L64_RS26085	COG0137	argininosuccinate synthase activity
C2L64_RS26100	COG0628	permease
C2L64_RS26110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS26125	COG3008	intermembrane lipid transfer
C2L64_RS26125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L64_RS26155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2L64_RS26175	COG2207	Transcriptional regulator
C2L64_RS26180	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS26185	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS26190	COG1129	ABC transporter
C2L64_RS26195	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS26205	COG1253	flavin adenine dinucleotide binding
C2L64_RS26220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2L64_RS26230	COG4689	acetoacetate decarboxylase
C2L64_RS26235	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS26255	COG3550	peptidyl-serine autophosphorylation
C2L64_RS26280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS26300	COG0443	Heat shock 70 kDa protein
C2L64_RS26305	COG0443	Heat shock 70 kDa protein
C2L64_RS26335	COG1403	HNH endonuclease
C2L64_RS26345	COG0583	DNA-binding transcription factor activity
C2L64_RS26370	COG0642	Histidine kinase
C2L64_RS26400	COG0484	heat shock protein binding
C2L64_RS26420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2L64_RS26425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS26435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2L64_RS26455	COG1501	Belongs to the glycosyl hydrolase 31 family
C2L64_RS26460	COG2271	Major facilitator Superfamily
C2L64_RS26500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS26515	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
C2L64_RS26565	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C2L64_RS26605	COG0778	Nitroreductase
C2L64_RS26635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2L64_RS26640	COG0517	IMP dehydrogenase activity
C2L64_RS26650	COG2094	Belongs to the DNA glycosylase MPG family
C2L64_RS26660	COG0387	Pfam Sodium calcium exchanger
C2L64_RS26665	COG0583	DNA-binding transcription factor activity
C2L64_RS26670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS26675	COG0765	amino acid transport
C2L64_RS26680	COG0765	amino acid transport
C2L64_RS26700	COG0457	Tetratricopeptide repeat
C2L64_RS26705	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2L64_RS26710	COG1215	transferase activity, transferring glycosyl groups
C2L64_RS26715	COG1215	transferase activity, transferring glycosyl groups
C2L64_RS26720	COG2894	cell division
C2L64_RS26745	COG4942	peptidase
C2L64_RS26745	COG1388	LysM domain
C2L64_RS26755	COG1349	DNA-binding transcription factor activity
C2L64_RS26760	COG0494	nUDIX hydrolase
C2L64_RS26765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS26775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2L64_RS26795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2L64_RS26795	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS26810	COG2244	polysaccharide biosynthetic process
C2L64_RS26815	COG3206	protein involved in exopolysaccharide biosynthesis
C2L64_RS26815	COG0489	protein tyrosine kinase activity
C2L64_RS26825	COG1596	polysaccharide export
C2L64_RS26845	COG0657	acetylesterase activity
C2L64_RS26850	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS26850	COG0824	Thioesterase
C2L64_RS26855	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS26860	COG3246	L-lysine catabolic process to acetate
C2L64_RS26875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS26885	COG3119	arylsulfatase activity
C2L64_RS26915	COG4638	Rieske (2fe-2S)
C2L64_RS26925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2L64_RS26930	COG2181	nitrate reductase activity
C2L64_RS26930	COG0247	lactate metabolic process
C2L64_RS26935	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L64_RS26935	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS26980	COG1309	transcriptional regulator
C2L64_RS26985	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS26990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2L64_RS27000	COG0477	Major facilitator Superfamily
C2L64_RS27010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2L64_RS27015	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2L64_RS27025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS27070	COG0786	glutamate:sodium symporter activity
C2L64_RS27085	COG3008	intermembrane lipid transfer
C2L64_RS27085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2L64_RS27090	COG2995	paraquat-inducible protein a
C2L64_RS27130	COG4566	intracellular signal transduction
C2L64_RS27135	COG4191	Histidine kinase
C2L64_RS27150	COG4689	acetoacetate decarboxylase
C2L64_RS27215	COG3447	MASE1 domain protein
C2L64_RS27215	COG5001	Diguanylate cyclase
C2L64_RS27215	COG5002	protein histidine kinase activity
C2L64_RS27230	COG2207	Transcriptional regulator
C2L64_RS27235	COG1064	alcohol dehydrogenase
C2L64_RS27240	COG0583	DNA-binding transcription factor activity
C2L64_RS27265	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L64_RS27265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2L64_RS27280	COG1760	l-serine dehydratase
C2L64_RS27310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2L64_RS27340	COG5002	protein histidine kinase activity
C2L64_RS27340	COG0784	Response regulator, receiver
C2L64_RS27365	COG0625	glutathione transferase activity
C2L64_RS27370	COG0735	belongs to the Fur family
C2L64_RS27415	COG1309	transcriptional regulator
C2L64_RS27445	COG4413	Urea transporter
C2L64_RS27450	COG0235	Class ii aldolase
C2L64_RS27455	COG1942	4-Oxalocrotonate Tautomerase
C2L64_RS27460	COG1271	oxidase subunit
C2L64_RS27465	COG1294	oxidase, subunit
C2L64_RS27470	COG2197	response regulator
C2L64_RS27480	COG2205	protein histidine kinase activity
C2L64_RS27480	COG0784	Response regulator, receiver
C2L64_RS27495	COG0277	FAD linked oxidase domain protein
C2L64_RS27505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS27515	COG0765	amino acid transport
C2L64_RS27530	COG2188	Transcriptional regulator
C2L64_RS27535	COG2986	histidine ammonia-lyase
C2L64_RS27575	COG0028	Belongs to the TPP enzyme family
C2L64_RS27585	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2L64_RS27600	COG0583	DNA-binding transcription factor activity
C2L64_RS27610	COG2814	Major facilitator Superfamily
C2L64_RS27630	COG3052	prosthetic group binding
C2L64_RS27650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2L64_RS27670	COG1408	metallophosphoesterase
C2L64_RS27675	COG0427	acetyl-CoA hydrolase
C2L64_RS27690	COG0583	DNA-binding transcription factor activity
C2L64_RS27725	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS27760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L64_RS27765	COG1349	DNA-binding transcription factor activity
C2L64_RS27770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2L64_RS27820	COG1742	UPF0060 membrane protein
C2L64_RS27830	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS27865	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS27875	COG0642	Histidine kinase
C2L64_RS27895	COG1464	Belongs to the NlpA lipoprotein family
C2L64_RS27900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS27910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L64_RS27920	COG0129	dihydroxy-acid dehydratase activity
C2L64_RS27930	COG0596	Alpha beta hydrolase
C2L64_RS27940	COG2207	Transcriptional regulator
C2L64_RS27960	COG0154	amidase activity
C2L64_RS27975	COG4566	intracellular signal transduction
C2L64_RS27980	COG4566	intracellular signal transduction
C2L64_RS27985	COG4191	Histidine kinase
C2L64_RS27990	COG0596	Alpha beta hydrolase
C2L64_RS27995	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS28000	COG0596	Alpha beta hydrolase
C2L64_RS28010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2L64_RS28010	COG0785	Cytochrome C biogenesis protein
C2L64_RS28025	COG1064	alcohol dehydrogenase
C2L64_RS28040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS28045	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2L64_RS28050	COG2080	2 iron, 2 sulfur cluster binding
C2L64_RS28060	COG1024	Enoyl-CoA hydratase
C2L64_RS28065	COG1024	Enoyl-CoA hydratase
C2L64_RS28080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2L64_RS28085	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS28100	COG0330	HflC and HflK could
C2L64_RS28110	COG2252	PERMEase
C2L64_RS28115	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS28145	COG3158	transport of potassium into the cell
C2L64_RS28185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2L64_RS28210	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS28215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS28235	COG0726	polysaccharide deacetylase
C2L64_RS28240	COG2261	transglycosylase associated protein
C2L64_RS28275	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS28280	COG0583	DNA-binding transcription factor activity
C2L64_RS28305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS28310	COG0045	succinate-CoA ligase (ADP-forming) activity
C2L64_RS28320	COG1802	Transcriptional regulator
C2L64_RS28330	COG2223	nitrite transmembrane transporter activity
C2L64_RS28340	COG2205	protein histidine kinase activity
C2L64_RS28345	COG0842	Transport permease protein
C2L64_RS28350	COG1131	(ABC) transporter
C2L64_RS28360	COG3485	protocatechuate 3,4-dioxygenase
C2L64_RS28370	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS28385	COG0583	DNA-binding transcription factor activity
C2L64_RS28410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2L64_RS28410	COG1793	dna ligase
C2L64_RS28415	COG1793	dna ligase
C2L64_RS28445	COG0477	Major facilitator Superfamily
C2L64_RS28465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS28480	COG2175	clavaminate synthase activity
C2L64_RS28490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS28510	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS28525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS28535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS28545	COG4191	Histidine kinase
C2L64_RS28555	COG0028	Belongs to the TPP enzyme family
C2L64_RS28560	COG1802	Transcriptional regulator
C2L64_RS28575	COG1802	Transcriptional regulator
C2L64_RS28590	COG5507	3-demethylubiquinone-9 3-methyltransferase
C2L64_RS28610	COG0668	transmembrane transport
C2L64_RS28615	COG1136	(ABC) transporter
C2L64_RS28680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2L64_RS28690	COG0683	leucine binding
C2L64_RS28695	COG3634	alkyl hydroperoxide reductase activity
C2L64_RS28705	COG0417	DNA replication proofreading
C2L64_RS28710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS28730	COG0659	secondary active sulfate transmembrane transporter activity
C2L64_RS28735	COG0288	reversible hydration of carbon dioxide
C2L64_RS28750	COG0583	DNA-binding transcription factor activity
C2L64_RS28760	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2L64_RS28770	COG1285	pathogenesis
C2L64_RS28820	COG0393	Putative heavy-metal-binding
C2L64_RS28835	COG1414	Transcriptional regulator
C2L64_RS28840	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS28860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2L64_RS28885	COG0778	Nitroreductase
C2L64_RS28890	COG0583	DNA-binding transcription factor activity
C2L64_RS28920	COG0129	dihydroxy-acid dehydratase activity
C2L64_RS28925	COG1609	Transcriptional regulator
C2L64_RS28935	COG4797	methyltransferase
C2L64_RS28935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2L64_RS28965	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2L64_RS28975	COG0625	glutathione transferase activity
C2L64_RS29005	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS29010	COG0583	DNA-binding transcription factor activity
C2L64_RS29015	COG3795	YCII-related domain
C2L64_RS29030	COG0577	efflux transmembrane transporter activity
C2L64_RS29030	COG1136	(ABC) transporter
C2L64_RS29040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2L64_RS29080	COG1802	Transcriptional regulator
C2L64_RS29085	COG2271	Major facilitator Superfamily
C2L64_RS29095	COG0583	DNA-binding transcription factor activity
C2L64_RS29105	COG0596	Alpha beta hydrolase
C2L64_RS29105	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2L64_RS29120	COG2816	NAD+ diphosphatase activity
C2L64_RS29130	COG0583	DNA-binding transcription factor activity
C2L64_RS29135	COG0583	DNA-binding transcription factor activity
C2L64_RS29170	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS29220	COG1349	DNA-binding transcription factor activity
C2L64_RS29225	COG2223	nitrite transmembrane transporter activity
C2L64_RS29230	COG0598	Magnesium transport protein CorA
C2L64_RS29245	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C2L64_RS29255	COG4221	oxidoreductase activity
C2L64_RS29270	COG1278	Cold shock
C2L64_RS29280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS29300	COG0583	DNA-binding transcription factor activity
C2L64_RS29305	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2L64_RS29340	COG0431	NADPH-dependent FMN reductase
C2L64_RS29345	COG3384	dioxygenase
C2L64_RS29350	COG2159	amidohydrolase
C2L64_RS29370	COG3246	L-lysine catabolic process to acetate
C2L64_RS29375	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS29390	COG1024	Enoyl-CoA hydratase
C2L64_RS29395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS29400	COG2271	Major facilitator Superfamily
C2L64_RS29410	COG4221	oxidoreductase activity
C2L64_RS29415	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS29420	COG4221	oxidoreductase activity
C2L64_RS29425	COG2207	Transcriptional regulator
C2L64_RS29435	COG1538	Outer membrane efflux protein
C2L64_RS29445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS29455	COG0583	DNA-binding transcription factor activity
C2L64_RS29465	COG2072	flavoprotein involved in K transport
C2L64_RS29490	COG1126	abc transporter atp-binding protein
C2L64_RS29500	COG4215	(ABC) transporter
C2L64_RS29505	COG0765	amino acid transport
C2L64_RS29510	COG0789	Transcriptional regulator
C2L64_RS29525	COG0601	transmembrane transport
C2L64_RS29530	COG0747	negative chemotaxis
C2L64_RS29535	COG2011	ABC-type metal ion transport system permease component
C2L64_RS29540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2L64_RS29545	COG1464	Belongs to the NlpA lipoprotein family
C2L64_RS29565	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2L64_RS29585	COG1301	dicarboxylic acid transport
C2L64_RS29600	COG0477	Major facilitator Superfamily
C2L64_RS29610	COG0583	DNA-binding transcription factor activity
C2L64_RS29615	COG2186	Transcriptional regulator
C2L64_RS29625	COG1850	ribulose-bisphosphate carboxylase activity
C2L64_RS29640	COG1278	Cold shock
C2L64_RS29685	COG0300	oxidoreductase activity
C2L64_RS29705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2L64_RS29720	COG4172	Belongs to the ABC transporter superfamily
C2L64_RS29730	COG0601	transmembrane transport
C2L64_RS29735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS29750	COG0753	catalase activity
C2L64_RS29760	COG3220	belongs to the UPF0276 family
C2L64_RS29785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2L64_RS29795	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L64_RS29800	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2L64_RS29805	COG2814	Major facilitator Superfamily
C2L64_RS29825	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS29850	COG0583	DNA-binding transcription factor activity
C2L64_RS29855	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS29860	COG4829	muconolactone delta-isomerase
C2L64_RS29865	COG3135	benzoate transporter
C2L64_RS29900	COG1278	Cold shock
C2L64_RS29960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS29970	COG1278	Cold shock
C2L64_RS30035	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS30040	COG2186	Transcriptional regulator
C2L64_RS30055	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS30075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS30090	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS30100	COG0583	DNA-binding transcription factor activity
C2L64_RS30135	COG1946	Acyl-CoA thioesterase
C2L64_RS30140	COG0633	Ferredoxin
C2L64_RS30150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS30155	COG1024	Enoyl-CoA hydratase
C2L64_RS30160	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS30165	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS30175	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS30185	COG2271	Major facilitator Superfamily
C2L64_RS30205	COG2814	Major facilitator Superfamily
C2L64_RS30245	COG0058	SHG alpha-glucan phosphorylase activity
C2L64_RS30255	COG2814	Major facilitator Superfamily
C2L64_RS30260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2L64_RS30295	COG0714	Associated with various cellular activities
C2L64_RS30330	COG1733	regulation of RNA biosynthetic process
C2L64_RS30350	COG0596	Alpha beta hydrolase
C2L64_RS30365	COG0583	DNA-binding transcription factor activity
C2L64_RS30370	COG2814	Major facilitator Superfamily
C2L64_RS30375	COG1461	Dihydroxyacetone kinase
C2L64_RS30380	COG2376	Dihydroxyacetone kinase
C2L64_RS30385	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS30390	COG1129	ABC transporter
C2L64_RS30395	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS30400	COG0235	Class ii aldolase
C2L64_RS30405	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2L64_RS30410	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2L64_RS30415	COG2188	Transcriptional regulator
C2L64_RS30435	COG1175	transmembrane transport
C2L64_RS30455	COG1063	alcohol dehydrogenase
C2L64_RS30460	COG1063	alcohol dehydrogenase
C2L64_RS30485	COG0235	Class ii aldolase
C2L64_RS30510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS30515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS30520	COG4221	oxidoreductase activity
C2L64_RS30525	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS30550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS30555	COG0583	DNA-binding transcription factor activity
C2L64_RS30575	COG2837	iron assimilation
C2L64_RS30590	COG3842	ATPase activity
C2L64_RS30605	COG0745	RESPONSE REGULATOR receiver
C2L64_RS30610	COG0642	Histidine kinase
C2L64_RS30635	COG2267	carboxylic ester hydrolase activity
C2L64_RS30640	COG2353	YceI-like domain
C2L64_RS30650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS30655	COG0583	DNA-binding transcription factor activity
C2L64_RS30720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2L64_RS30740	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS30750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L64_RS30755	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
C2L64_RS30755	COG0028	Belongs to the TPP enzyme family
C2L64_RS30775	COG0840	transmembrane signaling receptor activity
C2L64_RS30815	COG2204	response regulator
C2L64_RS30825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2L64_RS30860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2L64_RS30860	COG0515	serine threonine protein kinase
C2L64_RS30865	COG2815	serine threonine protein kinase
C2L64_RS30865	COG0515	serine threonine protein kinase
C2L64_RS30880	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2L64_RS30995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS31000	COG3162	membrane
C2L64_RS31005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2L64_RS31020	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2L64_RS31070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2L64_RS31090	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS31105	COG0589	response to stress
C2L64_RS31135	COG1739	Uncharacterized protein family UPF0029
C2L64_RS31145	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS31150	COG2271	Major facilitator Superfamily
C2L64_RS31155	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS31165	COG0586	Pfam SNARE associated Golgi protein
C2L64_RS31180	COG3706	GGDEF domain
C2L64_RS31190	COG0306	phosphate transporter
C2L64_RS31215	COG0477	Major facilitator Superfamily
C2L64_RS31245	COG0537	adenosine 5'-monophosphoramidase activity
C2L64_RS31255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS31275	COG1115	amino acid carrier protein
C2L64_RS31285	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS31305	COG0583	DNA-binding transcription factor activity
C2L64_RS31310	COG3485	protocatechuate 3,4-dioxygenase
C2L64_RS31315	COG3485	protocatechuate 3,4-dioxygenase
C2L64_RS31320	COG0235	Class ii aldolase
C2L64_RS31330	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS31340	COG1801	Protein of unknown function DUF72
C2L64_RS31355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2L64_RS31370	COG0583	DNA-binding transcription factor activity
C2L64_RS31375	COG1741	Belongs to the pirin family
C2L64_RS31380	COG2259	Doxx family
C2L64_RS31435	COG0625	glutathione transferase activity
C2L64_RS31450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS31485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C2L64_RS31510	COG2205	protein histidine kinase activity
C2L64_RS31515	COG0745	RESPONSE REGULATOR receiver
C2L64_RS31540	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS31560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2L64_RS31575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2L64_RS31580	COG2081	HI0933 family
C2L64_RS31585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2L64_RS31590	COG1469	GTP cyclohydrolase I activity
C2L64_RS31595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2L64_RS31600	COG0142	geranyltranstransferase activity
C2L64_RS31605	COG1722	exodeoxyribonuclease VII activity
C2L64_RS31620	COG0412	Dienelactone hydrolase
C2L64_RS31625	COG1252	NADH dehydrogenase
C2L64_RS31635	COG1611	Belongs to the LOG family
C2L64_RS31640	COG0583	DNA-binding transcription factor activity
C2L64_RS31655	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS31660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2L64_RS31670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2L64_RS31680	COG1846	Transcriptional regulator
C2L64_RS31685	COG1764	response to oxidative stress
C2L64_RS31690	COG0415	Belongs to the DNA photolyase family
C2L64_RS31715	COG4149	molybdate abc transporter
C2L64_RS31720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C2L64_RS31730	COG1942	4-Oxalocrotonate Tautomerase
C2L64_RS31735	COG0583	DNA-binding transcription factor activity
C2L64_RS31745	COG5642	Protein of unknown function (DUF2384)
C2L64_RS31750	COG5654	RES domain protein
C2L64_RS31755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2L64_RS31780	COG0366	Alpha amylase catalytic
C2L64_RS31785	COG0366	Alpha amylase catalytic
C2L64_RS31790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2L64_RS31800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2L64_RS31805	COG1640	4-alpha-glucanotransferase
C2L64_RS31815	COG1253	flavin adenine dinucleotide binding
C2L64_RS31820	COG2202	Pas domain
C2L64_RS31820	COG2205	protein histidine kinase activity
C2L64_RS31855	COG0285	dihydrofolate synthase activity
C2L64_RS31860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2L64_RS31865	COG0159	tryptophan synthase activity
C2L64_RS31875	COG0133	tryptophan synthase activity
C2L64_RS31880	COG0135	phosphoribosylanthranilate isomerase activity
C2L64_RS31885	COG0101	tRNA pseudouridine synthase activity
C2L64_RS31900	COG0473	3-isopropylmalate dehydrogenase activity
C2L64_RS31905	COG0066	3-isopropylmalate dehydratase activity
C2L64_RS31910	COG5510	response to toxic substance
C2L64_RS31915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2L64_RS31925	COG0372	Belongs to the citrate synthase family
C2L64_RS31930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2L64_RS31935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2L64_RS31940	COG1053	succinate dehydrogenase
C2L64_RS31955	COG2188	Transcriptional regulator
C2L64_RS31960	COG0039	L-malate dehydrogenase activity
C2L64_RS31990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2L64_RS32000	COG0739	heme binding
C2L64_RS32000	COG0741	lytic transglycosylase activity
C2L64_RS32000	COG1196	nuclear chromosome segregation
C2L64_RS32030	COG4964	Belongs to the GSP D family
C2L64_RS32065	COG5295	Hep Hag repeat protein
C2L64_RS32065	COG5295	Hep Hag repeat protein
C2L64_RS32065	COG5295	Hep Hag repeat protein
C2L64_RS32080	COG2197	response regulator
C2L64_RS32105	COG1309	transcriptional regulator
C2L64_RS32115	COG1131	(ABC) transporter
C2L64_RS32120	COG0842	Transport permease protein
C2L64_RS32140	COG1177	transmembrane transport
C2L64_RS32145	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS32155	COG3842	ATPase activity
C2L64_RS32165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2L64_RS32185	COG2217	Heavy metal translocating P-type atpase
C2L64_RS32190	COG0840	transmembrane signaling receptor activity
C2L64_RS32205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L64_RS32210	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS32225	COG1285	pathogenesis
C2L64_RS32235	COG0840	transmembrane signaling receptor activity
C2L64_RS32250	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS32255	COG3618	amidohydrolase
C2L64_RS32265	COG2721	sulfolactate sulfo-lyase activity
C2L64_RS32275	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS32280	COG1129	ABC transporter
C2L64_RS32300	COG0045	succinate-CoA ligase (ADP-forming) activity
C2L64_RS32300	COG1042	CoA-binding domain protein
C2L64_RS32300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2L64_RS32310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2L64_RS32320	COG3188	usher protein
C2L64_RS32325	COG3121	Chaperone
C2L64_RS32340	COG3188	usher protein
C2L64_RS32345	COG3121	Chaperone
C2L64_RS32350	COG3539	Fimbrial protein
C2L64_RS32355	COG0477	Major facilitator Superfamily
C2L64_RS32365	COG0667	Aldo Keto reductase
C2L64_RS32370	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
C2L64_RS32375	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L64_RS32405	COG2610	gluconate transmembrane transporter activity
C2L64_RS32440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS32445	COG0840	transmembrane signaling receptor activity
C2L64_RS32450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2L64_RS32465	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS32475	COG3214	Protein conserved in bacteria
C2L64_RS32495	COG0697	spore germination
C2L64_RS32510	COG0247	lactate metabolic process
C2L64_RS32520	COG2271	Major facilitator Superfamily
C2L64_RS32525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2L64_RS32530	COG1802	Transcriptional regulator
C2L64_RS32540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS32545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS32550	COG0583	DNA-binding transcription factor activity
C2L64_RS32570	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS32575	COG0477	Major facilitator Superfamily
C2L64_RS32590	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS32600	COG3960	tartronate-semialdehyde synthase activity
C2L64_RS32605	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS32610	COG1414	Transcriptional regulator
C2L64_RS32615	COG2226	methyltransferase
C2L64_RS32615	COG1073	alpha beta
C2L64_RS32625	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS32650	COG1414	Transcriptional regulator
C2L64_RS32670	COG2885	chlorophyll binding
C2L64_RS32760	COG1446	asparaginase
C2L64_RS32765	COG4172	Belongs to the ABC transporter superfamily
C2L64_RS32770	COG0747	negative chemotaxis
C2L64_RS32780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS32845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2L64_RS32865	COG3177	Filamentation induced by cAMP protein fic
C2L64_RS32875	COG1360	Flagellar Motor Protein
C2L64_RS32895	COG4221	oxidoreductase activity
C2L64_RS32905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS32910	COG0583	DNA-binding transcription factor activity
C2L64_RS32935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS32985	COG2353	YceI-like domain
C2L64_RS33005	COG2366	antibiotic biosynthetic process
C2L64_RS33030	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2L64_RS33045	COG2814	Major facilitator Superfamily
C2L64_RS33055	COG1032	radical SAM domain protein
C2L64_RS33080	COG5002	protein histidine kinase activity
C2L64_RS33085	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS33085	COG3321	synthase
C2L64_RS33085	COG0604	alcohol dehydrogenase
C2L64_RS33090	COG0583	DNA-binding transcription factor activity
C2L64_RS33110	COG2353	YceI-like domain
C2L64_RS33115	COG1063	alcohol dehydrogenase
C2L64_RS33120	COG0156	8-amino-7-oxononanoate synthase activity
C2L64_RS33175	COG2733	membrane
C2L64_RS33195	COG2818	Glycosylase
C2L64_RS33240	COG3284	Transcriptional regulator
C2L64_RS33245	COG0596	Alpha beta hydrolase
C2L64_RS33280	COG0671	phosphoesterase, PA-phosphatase related
C2L64_RS33295	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS33315	COG0204	Acyl-transferase
C2L64_RS33345	COG1773	rubredoxin
C2L64_RS33380	COG2070	2-Nitropropane dioxygenase
C2L64_RS33385	COG2258	MOSC domain
C2L64_RS33395	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS33400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS33405	COG3162	membrane
C2L64_RS33410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS33420	COG2070	2-Nitropropane dioxygenase
C2L64_RS33425	COG2271	Major facilitator Superfamily
C2L64_RS33435	COG1609	Transcriptional regulator
C2L64_RS33455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS33460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS33465	COG3976	FMN-binding domain protein
C2L64_RS33465	COG1053	succinate dehydrogenase
C2L64_RS33470	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS33475	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS33485	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS33495	COG0673	inositol 2-dehydrogenase activity
C2L64_RS33500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS33505	COG1053	succinate dehydrogenase
C2L64_RS33545	COG0840	transmembrane signaling receptor activity
C2L64_RS33550	COG2814	Major facilitator Superfamily
C2L64_RS33565	COG0583	DNA-binding transcription factor activity
C2L64_RS33570	COG0686	Belongs to the AlaDH PNT family
C2L64_RS33575	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS33585	COG1840	ABC-type Fe3 transport system, periplasmic component
C2L64_RS33590	COG3842	ATPase activity
C2L64_RS33605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS33630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2L64_RS33685	COG0010	Belongs to the arginase family
C2L64_RS33705	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS33710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2L64_RS33760	COG0506	proline dehydrogenase activity
C2L64_RS33805	COG0583	DNA-binding transcription factor activity
C2L64_RS33810	COG4221	oxidoreductase activity
C2L64_RS33835	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS33920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS33985	COG0477	Major facilitator Superfamily
C2L64_RS34000	COG0583	DNA-binding transcription factor activity
C2L64_RS34010	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS34010	COG2207	Transcriptional regulator
C2L64_RS34015	COG0028	Belongs to the TPP enzyme family
C2L64_RS34025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2L64_RS34035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS34040	COG0567	Dehydrogenase, E1 component
C2L64_RS34045	COG0583	DNA-binding transcription factor activity
C2L64_RS34065	COG2188	Transcriptional regulator
C2L64_RS34070	COG2814	Major facilitator Superfamily
C2L64_RS34090	COG2814	Major facilitator Superfamily
C2L64_RS34095	COG0583	DNA-binding transcription factor activity
C2L64_RS34110	COG2814	Major facilitator Superfamily
C2L64_RS34115	COG0583	DNA-binding transcription factor activity
C2L64_RS34120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS34150	COG0784	Response regulator, receiver
C2L64_RS34150	COG4191	Histidine kinase
C2L64_RS34180	COG0596	Alpha beta hydrolase
C2L64_RS34275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS34280	COG1301	dicarboxylic acid transport
C2L64_RS34290	COG1301	dicarboxylic acid transport
C2L64_RS34355	COG0840	transmembrane signaling receptor activity
C2L64_RS34360	COG0583	DNA-binding transcription factor activity
C2L64_RS34395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS34400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS34405	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS34415	COG1129	ABC transporter
C2L64_RS34425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS34430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2L64_RS34435	COG1126	abc transporter atp-binding protein
C2L64_RS34465	COG1126	abc transporter atp-binding protein
C2L64_RS34480	COG1609	Transcriptional regulator
C2L64_RS34485	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS34490	COG1129	ABC transporter
C2L64_RS34495	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS34565	COG3459	Glycosyltransferase 36 associated
C2L64_RS34625	COG1201	RNA secondary structure unwinding
C2L64_RS34630	COG3706	GGDEF domain
C2L64_RS34635	COG0583	DNA-binding transcription factor activity
C2L64_RS34640	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2L64_RS34645	COG2031	fatty acid transporter
C2L64_RS34650	COG0840	transmembrane signaling receptor activity
C2L64_RS34680	COG1024	Enoyl-CoA hydratase
C2L64_RS34685	COG4191	Histidine kinase
C2L64_RS34690	COG0583	DNA-binding transcription factor activity
C2L64_RS34695	COG0596	Alpha beta hydrolase
C2L64_RS34700	COG4566	intracellular signal transduction
C2L64_RS34720	COG2186	Transcriptional regulator
C2L64_RS34740	COG0583	DNA-binding transcription factor activity
C2L64_RS34745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2L64_RS34750	COG0583	DNA-binding transcription factor activity
C2L64_RS34755	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2L64_RS34760	COG1024	Enoyl-CoA hydratase
C2L64_RS34790	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS34815	COG2814	Major facilitator Superfamily
C2L64_RS34820	COG2271	Major facilitator Superfamily
C2L64_RS34825	COG0840	transmembrane signaling receptor activity
C2L64_RS34830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2L64_RS34835	COG0583	DNA-binding transcription factor activity
C2L64_RS34850	COG0346	lactoylglutathione lyase activity
C2L64_RS34855	COG0667	Aldo Keto reductase
C2L64_RS34860	COG4566	intracellular signal transduction
C2L64_RS34865	COG4191	Histidine kinase
C2L64_RS34870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS34890	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS34905	COG0583	DNA-binding transcription factor activity
C2L64_RS34910	COG0303	'Molybdopterin
C2L64_RS34915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2L64_RS34920	COG1294	oxidase, subunit
C2L64_RS34925	COG1271	oxidase subunit
C2L64_RS34930	COG0243	molybdopterin cofactor binding
C2L64_RS34945	COG0583	DNA-binding transcription factor activity
C2L64_RS34970	COG4176	ABC-type proline glycine betaine transport system permease component
C2L64_RS34975	COG2113	Glycine betaine
C2L64_RS34980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2L64_RS34985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS34995	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS35005	COG0583	DNA-binding transcription factor activity
C2L64_RS35030	COG4638	Rieske (2fe-2S)
C2L64_RS35040	COG0006	proline dipeptidase activity
C2L64_RS35050	COG0583	DNA-binding transcription factor activity
C2L64_RS35060	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS35075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS35080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS35095	COG0789	Transcriptional regulator
C2L64_RS35120	COG0154	amidase activity
C2L64_RS35125	COG1335	isochorismatase
C2L64_RS35135	COG3845	ABC transporter
C2L64_RS35140	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS35145	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS35155	COG3833	ABC-type maltose transport systems, permease component
C2L64_RS35160	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS35170	COG3842	ATPase activity
C2L64_RS35185	COG1802	Transcriptional regulator
C2L64_RS35190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2L64_RS35195	COG3608	succinylglutamate desuccinylase aspartoacylase
C2L64_RS35205	COG0747	negative chemotaxis
C2L64_RS35225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS35230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS35240	COG1422	Protein of unknown function (DUF1090)
C2L64_RS35275	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS35280	COG3842	ATPase activity
C2L64_RS35285	COG0395	ABC-type sugar transport system, permease component
C2L64_RS35290	COG1175	transmembrane transport
C2L64_RS35300	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS35305	COG1024	Enoyl-CoA hydratase
C2L64_RS35315	COG0673	inositol 2-dehydrogenase activity
C2L64_RS35320	COG1609	Transcriptional regulator
C2L64_RS35325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS35345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2L64_RS35350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS35380	COG2814	Major facilitator Superfamily
C2L64_RS35425	COG0543	2 iron, 2 sulfur cluster binding
C2L64_RS35430	COG0167	dihydroorotate dehydrogenase activity
C2L64_RS35440	COG0252	asparaginase activity
C2L64_RS35455	COG1473	amidohydrolase
C2L64_RS35460	COG1473	amidohydrolase
C2L64_RS35475	COG1473	amidohydrolase
C2L64_RS35485	COG4638	Rieske (2fe-2S)
C2L64_RS35500	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS35530	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS35545	COG2423	ornithine cyclodeaminase activity
C2L64_RS35550	COG1522	sequence-specific DNA binding
C2L64_RS35570	COG2186	Transcriptional regulator
C2L64_RS35575	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS35580	COG1129	ABC transporter
C2L64_RS35585	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS35590	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS35615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2L64_RS35640	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C2L64_RS35660	COG0023	Translation Initiation Factor
C2L64_RS35685	COG4191	Histidine kinase
C2L64_RS35750	COG4977	sequence-specific DNA binding
C2L64_RS35770	COG1301	dicarboxylic acid transport
C2L64_RS35790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS35795	COG1301	dicarboxylic acid transport
C2L64_RS35800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS35805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS35830	COG0683	leucine binding
C2L64_RS35860	COG0583	DNA-binding transcription factor activity
C2L64_RS35880	COG1454	alcohol dehydrogenase
C2L64_RS35885	COG2271	Major facilitator Superfamily
C2L64_RS35890	COG1304	FMN binding
C2L64_RS35895	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS35965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2L64_RS35985	COG0651	ATP synthesis coupled electron transport
C2L64_RS35990	COG0650	Formate hydrogenlyase subunit 4
C2L64_RS36000	COG0651	ATP synthesis coupled electron transport
C2L64_RS36005	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C2L64_RS36005	COG3261	NADH dehydrogenase
C2L64_RS36010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2L64_RS36035	COG2203	Gaf domain
C2L64_RS36035	COG3706	GGDEF domain
C2L64_RS36035	COG4251	negative regulation of phosphorylation
C2L64_RS36035	COG5001	Diguanylate cyclase
C2L64_RS36055	COG2391	methyltransferase activity
C2L64_RS36060	COG0640	Transcriptional regulator
C2L64_RS36125	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS36175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2L64_RS36200	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS36245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS36255	COG1120	ATPase activity
C2L64_RS36260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2L64_RS36285	COG1858	cytochrome C peroxidase
C2L64_RS36295	COG0038	chloride channel
C2L64_RS36300	COG0840	transmembrane signaling receptor activity
C2L64_RS36310	COG2271	Major facilitator Superfamily
C2L64_RS36405	COG4941	Belongs to the sigma-70 factor family
C2L64_RS36435	COG2271	Major facilitator Superfamily
C2L64_RS36455	COG0784	Response regulator, receiver
C2L64_RS36455	COG2205	protein histidine kinase activity
C2L64_RS36455	COG5002	protein histidine kinase activity
C2L64_RS36460	COG3706	GGDEF domain
C2L64_RS36460	COG2203	Gaf domain
C2L64_RS36460	COG4251	negative regulation of phosphorylation
C2L64_RS36460	COG5001	Diguanylate cyclase
C2L64_RS36465	COG0583	DNA-binding transcription factor activity
C2L64_RS36470	COG0444	Belongs to the ABC transporter superfamily
C2L64_RS36475	COG4608	Belongs to the ABC transporter superfamily
C2L64_RS36485	COG0601	transmembrane transport
C2L64_RS36490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS36500	COG2201	protein-glutamate methylesterase activity
C2L64_RS36505	COG0583	DNA-binding transcription factor activity
C2L64_RS36510	COG2851	Citrate transporter
C2L64_RS36535	COG0667	Aldo Keto reductase
C2L64_RS36540	COG3437	response regulator, receiver
C2L64_RS36545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS36550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS36565	COG1595	DNA-templated transcription, initiation
C2L64_RS36605	COG1764	response to oxidative stress
C2L64_RS36620	COG3842	ATPase activity
C2L64_RS36630	COG1177	transmembrane transport
C2L64_RS36655	COG0450	alkyl hydroperoxide reductase
C2L64_RS36660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS36670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS36675	COG1113	amino acid transport
C2L64_RS36695	COG0596	Alpha beta hydrolase
C2L64_RS36730	COG0583	DNA-binding transcription factor activity
C2L64_RS36735	COG0477	Major facilitator Superfamily
C2L64_RS36745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS36750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS36755	COG0477	Major facilitator Superfamily
C2L64_RS36760	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2L64_RS36765	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2L64_RS36780	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS36785	COG3384	dioxygenase
C2L64_RS36795	COG3971	2-oxopent-4-enoate hydratase activity
C2L64_RS36820	COG2313	pseudouridylate synthase activity
C2L64_RS36840	COG1214	PFAM Peptidase M22, glycoprotease
C2L64_RS36840	COG0456	acetyltransferase
C2L64_RS36845	COG2271	Major facilitator Superfamily
C2L64_RS36855	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS36865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS36875	COG0601	transmembrane transport
C2L64_RS36880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2L64_RS36910	COG0583	DNA-binding transcription factor activity
C2L64_RS36915	COG3842	ATPase activity
C2L64_RS36925	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C2L64_RS36930	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS36945	COG1598	PFAM Uncharacterised protein family UPF0150
C2L64_RS36970	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS36975	COG0473	3-isopropylmalate dehydrogenase activity
C2L64_RS36980	COG0583	DNA-binding transcription factor activity
C2L64_RS36985	COG1522	sequence-specific DNA binding
C2L64_RS36995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L64_RS37000	COG0456	acetyltransferase
C2L64_RS37035	COG2197	response regulator
C2L64_RS37050	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS37055	COG0583	DNA-binding transcription factor activity
C2L64_RS37075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS37100	COG0436	Aminotransferase
C2L64_RS37120	COG3047	cAMP biosynthetic process
C2L64_RS37135	COG0583	DNA-binding transcription factor activity
C2L64_RS37155	COG4702	Belongs to the UPF0303 family
C2L64_RS37175	COG2814	Major facilitator Superfamily
C2L64_RS37185	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS37190	COG0583	DNA-binding transcription factor activity
C2L64_RS37200	COG0723	plastoquinol--plastocyanin reductase activity
C2L64_RS37215	COG2814	Major facilitator Superfamily
C2L64_RS37245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2L64_RS37250	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS37255	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS37260	COG0583	DNA-binding transcription factor activity
C2L64_RS37285	COG0596	Alpha beta hydrolase
C2L64_RS37305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS37310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37350	COG1116	anion transmembrane transporter activity
C2L64_RS37355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS37390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2L64_RS37395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS37400	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2L64_RS37405	COG4521	taurine ABC transporter
C2L64_RS37415	COG2188	Transcriptional regulator
C2L64_RS37485	COG0583	DNA-binding transcription factor activity
C2L64_RS37595	COG0277	FAD linked oxidase domain protein
C2L64_RS37600	COG0583	DNA-binding transcription factor activity
C2L64_RS37610	COG1301	dicarboxylic acid transport
C2L64_RS37625	COG2188	Transcriptional regulator
C2L64_RS37635	COG1301	dicarboxylic acid transport
C2L64_RS37660	COG2205	protein histidine kinase activity
C2L64_RS37665	COG1294	oxidase, subunit
C2L64_RS37705	COG0667	Aldo Keto reductase
C2L64_RS37805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2L64_RS37810	COG2376	Dihydroxyacetone kinase
C2L64_RS37815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37830	COG1116	anion transmembrane transporter activity
C2L64_RS37840	COG4191	Histidine kinase
C2L64_RS37860	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS37865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37870	COG0583	DNA-binding transcription factor activity
C2L64_RS37890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS37910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS37915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS37930	COG2188	Transcriptional regulator
C2L64_RS37940	COG3415	Transposase
C2L64_RS37940	COG2801	Transposase and inactivated derivatives
C2L64_RS37960	COG2084	Dehydrogenase
C2L64_RS37965	COG3836	Belongs to the HpcH HpaI aldolase family
C2L64_RS37985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2L64_RS37985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2L64_RS37990	COG3706	GGDEF domain
C2L64_RS38005	COG2267	carboxylic ester hydrolase activity
C2L64_RS38015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS38020	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS38045	COG3842	ATPase activity
C2L64_RS38080	COG2031	fatty acid transporter
C2L64_RS38095	COG1183	phosphatidylcholine synthase activity
C2L64_RS38110	COG1538	Outer membrane efflux protein
C2L64_RS38155	COG0535	radical SAM domain protein
C2L64_RS38170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2L64_RS38180	COG2218	PFAM glutamate synthase alpha subunit domain protein
C2L64_RS38185	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
C2L64_RS38190	COG1229	Formylmethanofuran dehydrogenase subunit A
C2L64_RS38255	COG3954	Phosphoribulokinase
C2L64_RS38270	COG3284	Transcriptional regulator
C2L64_RS38285	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
C2L64_RS38300	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
C2L64_RS38310	COG0702	epimerase
C2L64_RS38320	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2L64_RS38330	COG2010	Cytochrome c
C2L64_RS38345	COG0583	DNA-binding transcription factor activity
C2L64_RS38350	COG2879	small protein
C2L64_RS38355	COG1966	Carbon starvation protein
C2L64_RS38370	COG2824	Alkylphosphonate utilization operon protein PhnA
C2L64_RS38400	COG0604	alcohol dehydrogenase
C2L64_RS38400	COG4221	oxidoreductase activity
C2L64_RS38400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L64_RS38400	COG3321	synthase
C2L64_RS38440	COG0583	DNA-binding transcription factor activity
C2L64_RS38445	COG2814	Major facilitator Superfamily
C2L64_RS38450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS38455	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS38460	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C2L64_RS38535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2L64_RS38545	COG4772	TonB-dependent receptor
C2L64_RS38550	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2L64_RS38555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L64_RS38585	COG5001	Diguanylate cyclase
C2L64_RS38590	COG0251	oxidation-reduction process
C2L64_RS38640	COG3123	guanosine phosphorylase activity
C2L64_RS38650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS38665	COG0477	Major facilitator Superfamily
C2L64_RS38670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS38680	COG1764	response to oxidative stress
C2L64_RS38700	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C2L64_RS38715	COG1024	Enoyl-CoA hydratase
C2L64_RS38720	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2L64_RS38740	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2L64_RS38755	COG1921	L-seryl-tRNASec selenium transferase activity
C2L64_RS38780	COG0778	Nitroreductase
C2L64_RS38790	COG2200	EAL domain
C2L64_RS38800	COG2175	clavaminate synthase activity
C2L64_RS38825	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2L64_RS38835	COG4175	Glycine betaine
C2L64_RS38845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2L64_RS38850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS38855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2L64_RS38860	COG1045	serine acetyltransferase
C2L64_RS38870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS38875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2L64_RS38880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS38885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS38890	COG1116	anion transmembrane transporter activity
C2L64_RS38925	COG3852	Histidine kinase
C2L64_RS38955	COG0515	serine threonine protein kinase
C2L64_RS38975	COG0631	protein serine/threonine phosphatase activity
C2L64_RS39080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS39085	COG0765	amino acid transport
C2L64_RS39090	COG1126	abc transporter atp-binding protein
C2L64_RS39095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS39100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2L64_RS39115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS39125	COG1686	Belongs to the peptidase S11 family
C2L64_RS39140	COG1278	Cold shock
C2L64_RS39195	COG1278	Cold shock
C2L64_RS39250	COG1615	UPF0182 protein
C2L64_RS39270	COG4977	sequence-specific DNA binding
C2L64_RS39350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS39355	COG2159	amidohydrolase
C2L64_RS39370	COG0583	DNA-binding transcription factor activity
C2L64_RS39380	COG0163	prenyltransferase activity
C2L64_RS39405	COG1024	Enoyl-CoA hydratase
C2L64_RS39415	COG0477	Major facilitator Superfamily
C2L64_RS39420	COG0583	DNA-binding transcription factor activity
C2L64_RS39430	COG3842	ATPase activity
C2L64_RS39445	COG0395	ABC-type sugar transport system, permease component
C2L64_RS39460	COG0583	DNA-binding transcription factor activity
C2L64_RS39465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS39470	COG1126	abc transporter atp-binding protein
C2L64_RS39475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS39480	COG0765	amino acid transport
C2L64_RS39495	COG0583	DNA-binding transcription factor activity
C2L64_RS39510	COG0840	transmembrane signaling receptor activity
C2L64_RS39515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS39520	COG0765	amino acid transport
C2L64_RS39525	COG0765	amino acid transport
C2L64_RS39530	COG1126	abc transporter atp-binding protein
C2L64_RS39555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS39560	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2L64_RS39565	COG4521	taurine ABC transporter
C2L64_RS39575	COG0583	DNA-binding transcription factor activity
C2L64_RS39585	COG0235	Class ii aldolase
C2L64_RS39595	COG2205	protein histidine kinase activity
C2L64_RS39595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS39600	COG1349	DNA-binding transcription factor activity
C2L64_RS39605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2L64_RS39610	COG3395	kinase activity
C2L64_RS39620	COG0583	DNA-binding transcription factor activity
C2L64_RS39630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS39635	COG2271	Major facilitator Superfamily
C2L64_RS39645	COG0583	DNA-binding transcription factor activity
C2L64_RS39650	COG0596	Alpha beta hydrolase
C2L64_RS39665	COG1595	DNA-templated transcription, initiation
C2L64_RS39680	COG0753	catalase activity
C2L64_RS39725	COG1301	dicarboxylic acid transport
C2L64_RS39730	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS39735	COG0583	DNA-binding transcription factor activity
C2L64_RS39775	COG3179	chitinase
C2L64_RS39780	COG0604	alcohol dehydrogenase
C2L64_RS39780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2L64_RS39780	COG3321	synthase
C2L64_RS39780	COG4221	oxidoreductase activity
C2L64_RS39790	COG0625	glutathione transferase activity
C2L64_RS39795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2L64_RS39795	COG0617	tRNA 3'-terminal CCA addition
C2L64_RS39795	COG0517	IMP dehydrogenase activity
C2L64_RS39800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2L64_RS39815	COG2207	Transcriptional regulator
C2L64_RS39860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2L64_RS39865	COG4789	Type iii secretion
C2L64_RS39880	COG4790	Type iii secretion
C2L64_RS39930	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS39945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2L64_RS39950	COG1845	cytochrome c oxidase, subunit III
C2L64_RS39955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L64_RS39960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2L64_RS39965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS39975	COG2721	sulfolactate sulfo-lyase activity
C2L64_RS39980	COG2186	Transcriptional regulator
C2L64_RS39990	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS39990	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS40000	COG2072	flavoprotein involved in K transport
C2L64_RS40015	COG2144	transferase activity, transferring acyl groups
C2L64_RS40040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS40045	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40050	COG0517	IMP dehydrogenase activity
C2L64_RS40065	COG1063	alcohol dehydrogenase
C2L64_RS40080	COG3851	Histidine kinase
C2L64_RS40085	COG2197	response regulator
C2L64_RS40095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS40135	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2L64_RS40165	COG1802	Transcriptional regulator
C2L64_RS40190	COG0477	Major facilitator Superfamily
C2L64_RS40195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS40225	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40235	COG2814	Major facilitator Superfamily
C2L64_RS40240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS40245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2L64_RS40260	COG1309	transcriptional regulator
C2L64_RS40270	COG0583	DNA-binding transcription factor activity
C2L64_RS40295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS40310	COG0583	DNA-binding transcription factor activity
C2L64_RS40315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS40400	COG0596	Alpha beta hydrolase
C2L64_RS40450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS40455	COG3665	Urea carboxylase-associated protein
C2L64_RS40460	COG3665	Urea carboxylase-associated protein
C2L64_RS40465	COG0765	amino acid transport
C2L64_RS40470	COG0765	amino acid transport
C2L64_RS40480	COG3665	Urea carboxylase-associated protein
C2L64_RS40510	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40515	COG2358	TRAP transporter, solute receptor (TAXI family
C2L64_RS40530	COG0778	Nitroreductase
C2L64_RS40535	COG0196	riboflavin kinase activity
C2L64_RS40545	COG3485	protocatechuate 3,4-dioxygenase
C2L64_RS40570	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2L64_RS40570	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS40575	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40605	COG1959	2 iron, 2 sulfur cluster binding
C2L64_RS40610	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS40625	COG0686	Belongs to the AlaDH PNT family
C2L64_RS40670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS40680	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS40685	COG0583	DNA-binding transcription factor activity
C2L64_RS40690	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C2L64_RS40695	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS40710	COG2301	Belongs to the HpcH HpaI aldolase family
C2L64_RS40715	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS40730	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2L64_RS40740	COG0411	ABC transporter
C2L64_RS40755	COG0683	leucine binding
C2L64_RS40760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2L64_RS40770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2L64_RS40780	COG0583	DNA-binding transcription factor activity
C2L64_RS40785	COG1414	Transcriptional regulator
C2L64_RS40790	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40795	COG2271	Major facilitator Superfamily
C2L64_RS40800	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40815	COG2814	Major facilitator Superfamily
C2L64_RS40825	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2L64_RS40830	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS40840	COG0583	DNA-binding transcription factor activity
C2L64_RS40855	COG0066	3-isopropylmalate dehydratase activity
C2L64_RS40860	COG1301	dicarboxylic acid transport
C2L64_RS40900	COG1335	isochorismatase
C2L64_RS40920	COG4977	sequence-specific DNA binding
C2L64_RS40920	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS40925	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS40945	COG0583	DNA-binding transcription factor activity
C2L64_RS40960	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS40965	COG1418	mRNA catabolic process
C2L64_RS40970	COG0583	DNA-binding transcription factor activity
C2L64_RS40980	COG0243	molybdopterin cofactor binding
C2L64_RS40985	COG1271	oxidase subunit
C2L64_RS40990	COG1294	oxidase, subunit
C2L64_RS40995	COG0783	Belongs to the Dps family
C2L64_RS41005	COG0583	DNA-binding transcription factor activity
C2L64_RS41020	COG4566	intracellular signal transduction
C2L64_RS41025	COG4191	Histidine kinase
C2L64_RS41055	COG0583	DNA-binding transcription factor activity
C2L64_RS41075	COG0596	Alpha beta hydrolase
C2L64_RS41085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2L64_RS41110	COG3220	belongs to the UPF0276 family
C2L64_RS41125	COG1764	response to oxidative stress
C2L64_RS41175	COG2205	protein histidine kinase activity
C2L64_RS41175	COG0784	Response regulator, receiver
C2L64_RS41175	COG2198	Histidine kinase
C2L64_RS41175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS41190	COG2271	Major facilitator Superfamily
C2L64_RS41200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS41215	COG0300	oxidoreductase activity
C2L64_RS41220	COG0583	DNA-binding transcription factor activity
C2L64_RS41230	COG5001	Diguanylate cyclase
C2L64_RS41230	COG1716	ATPase activity
C2L64_RS41250	COG0583	DNA-binding transcription factor activity
C2L64_RS41255	COG2204	response regulator
C2L64_RS41260	COG4191	Histidine kinase
C2L64_RS41265	COG3493	citrate carrier protein
C2L64_RS41275	COG1764	response to oxidative stress
C2L64_RS41285	COG1846	Transcriptional regulator
C2L64_RS41290	COG0243	molybdopterin cofactor binding
C2L64_RS41295	COG2146	nitrite reductase [NAD(P)H] activity
C2L64_RS41300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2L64_RS41320	COG0583	DNA-binding transcription factor activity
C2L64_RS41350	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS41360	COG2186	Transcriptional regulator
C2L64_RS41365	COG0277	FAD linked oxidase domain protein
C2L64_RS41370	COG0277	FAD linked oxidase domain protein
C2L64_RS41375	COG0247	lactate metabolic process
C2L64_RS41380	COG3550	peptidyl-serine autophosphorylation
C2L64_RS41390	COG0784	Response regulator, receiver
C2L64_RS41390	COG0835	chemotaxis
C2L64_RS41400	COG2733	membrane
C2L64_RS41425	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS41430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS41435	COG0235	Class ii aldolase
C2L64_RS41440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS41450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS41455	COG2814	Major facilitator Superfamily
C2L64_RS41460	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS41480	COG0583	DNA-binding transcription factor activity
C2L64_RS41500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2L64_RS41510	COG4191	Histidine kinase
C2L64_RS41515	COG4191	Histidine kinase
C2L64_RS41520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2L64_RS41530	COG1538	Outer membrane efflux protein
C2L64_RS41535	COG1289	transmembrane transporter activity
C2L64_RS41540	COG1566	PFAM secretion protein HlyD family protein
C2L64_RS41550	COG4566	intracellular signal transduction
C2L64_RS41555	COG4566	intracellular signal transduction
C2L64_RS41595	COG4566	intracellular signal transduction
C2L64_RS41600	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS41605	COG2271	Major facilitator Superfamily
C2L64_RS41610	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS41610	COG1024	Enoyl-CoA hydratase
C2L64_RS41620	COG1137	ATPase activity
C2L64_RS41625	COG1137	ATPase activity
C2L64_RS41660	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS41685	COG1137	ATPase activity
C2L64_RS41690	COG4177	L-phenylalanine transmembrane transporter activity
C2L64_RS41710	COG4336	lyase activity
C2L64_RS41715	COG2814	Major facilitator Superfamily
C2L64_RS41735	COG0583	DNA-binding transcription factor activity
C2L64_RS41740	COG0625	glutathione transferase activity
C2L64_RS41745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS41770	COG2146	nitrite reductase [NAD(P)H] activity
C2L64_RS41775	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2L64_RS41780	COG4638	Rieske (2fe-2S)
C2L64_RS41815	COG2814	Major facilitator Superfamily
C2L64_RS41820	COG0583	DNA-binding transcription factor activity
C2L64_RS41825	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2L64_RS41840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS41845	COG1024	Enoyl-CoA hydratase
C2L64_RS41850	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS41855	COG1960	acyl-CoA dehydrogenase activity
C2L64_RS41860	COG0183	Belongs to the thiolase family
C2L64_RS41865	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS41865	COG1024	Enoyl-CoA hydratase
C2L64_RS41875	COG1309	transcriptional regulator
C2L64_RS41905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2L64_RS41920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS41920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS41925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS41925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C2L64_RS41930	COG1024	Enoyl-CoA hydratase
C2L64_RS41935	COG1414	Transcriptional regulator
C2L64_RS41940	COG2814	Major facilitator Superfamily
C2L64_RS41945	COG3618	amidohydrolase
C2L64_RS41985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2L64_RS42000	COG0477	Major facilitator Superfamily
C2L64_RS42025	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS42040	COG2814	Major facilitator Superfamily
C2L64_RS42050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS42065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS42095	COG0163	prenyltransferase activity
C2L64_RS42105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS42110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2L64_RS42115	COG1309	transcriptional regulator
C2L64_RS42125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS42130	COG2864	formate dehydrogenase
C2L64_RS42135	COG0437	4 iron, 4 sulfur cluster binding
C2L64_RS42145	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42160	COG2823	Periplasmic or secreted lipoprotein
C2L64_RS42195	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42200	COG2094	Belongs to the DNA glycosylase MPG family
C2L64_RS42210	COG2814	Major facilitator Superfamily
C2L64_RS42230	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2L64_RS42250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2L64_RS42270	COG2072	flavoprotein involved in K transport
C2L64_RS42275	COG0583	DNA-binding transcription factor activity
C2L64_RS42285	COG3842	ATPase activity
C2L64_RS42295	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS42310	COG1017	nitric oxide dioxygenase activity
C2L64_RS42310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS42330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS42340	COG0477	Major facilitator Superfamily
C2L64_RS42360	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS42385	COG4670	ketone body catabolic process
C2L64_RS42390	COG2030	dehydratase
C2L64_RS42395	COG1609	Transcriptional regulator
C2L64_RS42420	COG0583	DNA-binding transcription factor activity
C2L64_RS42455	COG3179	chitinase
C2L64_RS42485	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2L64_RS42505	COG1802	Transcriptional regulator
C2L64_RS42510	COG1126	abc transporter atp-binding protein
C2L64_RS42540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS42550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2L64_RS42560	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS42565	COG0583	DNA-binding transcription factor activity
C2L64_RS42570	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42585	COG1024	Enoyl-CoA hydratase
C2L64_RS42595	COG2081	HI0933 family
C2L64_RS42600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS42615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS42620	COG2204	response regulator
C2L64_RS42700	COG0739	heme binding
C2L64_RS42700	COG0741	lytic transglycosylase activity
C2L64_RS42700	COG1196	nuclear chromosome segregation
C2L64_RS42745	COG0477	Major facilitator Superfamily
C2L64_RS42750	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS42765	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42770	COG0583	DNA-binding transcription factor activity
C2L64_RS42780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS42785	COG0596	Alpha beta hydrolase
C2L64_RS42790	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS42795	COG0583	DNA-binding transcription factor activity
C2L64_RS42800	COG0583	DNA-binding transcription factor activity
C2L64_RS42805	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42810	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS42820	COG0583	DNA-binding transcription factor activity
C2L64_RS42825	COG1335	isochorismatase
C2L64_RS42830	COG0625	glutathione transferase activity
C2L64_RS42840	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42850	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42855	COG0625	glutathione transferase activity
C2L64_RS42860	COG3829	transcription factor binding
C2L64_RS42885	COG0625	glutathione transferase activity
C2L64_RS42935	COG5265	(ABC) transporter
C2L64_RS42945	COG0583	DNA-binding transcription factor activity
C2L64_RS42950	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS42955	COG2271	Major facilitator Superfamily
C2L64_RS42960	COG3959	Transketolase, thiamine diphosphate binding domain
C2L64_RS42965	COG3958	Transketolase
C2L64_RS42970	COG0583	DNA-binding transcription factor activity
C2L64_RS42980	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS42995	COG2207	Transcriptional regulator
C2L64_RS43000	COG0300	oxidoreductase activity
C2L64_RS43005	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS43010	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS43020	COG3246	L-lysine catabolic process to acetate
C2L64_RS43035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2L64_RS43040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS43070	COG2165	general secretion pathway protein
C2L64_RS43110	COG2165	general secretion pathway protein
C2L64_RS43115	COG3250	beta-galactosidase activity
C2L64_RS43120	COG0673	inositol 2-dehydrogenase activity
C2L64_RS43125	COG3321	synthase
C2L64_RS43125	COG0604	alcohol dehydrogenase
C2L64_RS43130	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS43155	COG1764	response to oxidative stress
C2L64_RS43170	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS43180	COG1129	ABC transporter
C2L64_RS43185	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS43205	COG0596	Alpha beta hydrolase
C2L64_RS43215	COG2271	Major facilitator Superfamily
C2L64_RS43220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS43235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2L64_RS43250	COG0583	DNA-binding transcription factor activity
C2L64_RS43260	COG2814	Major facilitator Superfamily
C2L64_RS43270	COG0590	tRNA wobble adenosine to inosine editing
C2L64_RS43275	COG0840	transmembrane signaling receptor activity
C2L64_RS43290	COG0667	Aldo Keto reductase
C2L64_RS43295	COG0596	Alpha beta hydrolase
C2L64_RS43315	COG0583	DNA-binding transcription factor activity
C2L64_RS43330	COG0840	transmembrane signaling receptor activity
C2L64_RS43335	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2L64_RS43340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2L64_RS43345	COG1053	succinate dehydrogenase
C2L64_RS43365	COG3039	Transposase
C2L64_RS43375	COG4221	oxidoreductase activity
C2L64_RS43395	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS43415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2L64_RS43430	COG1063	alcohol dehydrogenase
C2L64_RS43440	COG1280	lysine exporter protein (LysE YggA)
C2L64_RS43445	COG0583	DNA-binding transcription factor activity
C2L64_RS43460	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2L64_RS43485	COG4993	Dehydrogenase
C2L64_RS43490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS43500	COG0477	Major facilitator Superfamily
C2L64_RS43510	COG0656	L-ascorbic acid biosynthetic process
C2L64_RS43535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS43540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS43555	COG1764	response to oxidative stress
C2L64_RS43590	COG0583	DNA-binding transcription factor activity
C2L64_RS43615	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS43620	COG0583	DNA-binding transcription factor activity
C2L64_RS43625	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS43635	COG1252	NADH dehydrogenase
C2L64_RS43640	COG0583	DNA-binding transcription factor activity
C2L64_RS43645	COG2814	Major facilitator Superfamily
C2L64_RS43655	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS43665	COG0028	Belongs to the TPP enzyme family
C2L64_RS43675	COG0477	Major facilitator Superfamily
C2L64_RS43695	COG2207	Transcriptional regulator
C2L64_RS43705	COG2814	Major facilitator Superfamily
C2L64_RS43730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS43740	COG0840	transmembrane signaling receptor activity
C2L64_RS43745	COG1309	transcriptional regulator
C2L64_RS43750	COG3180	Ammonia monooxygenase
C2L64_RS43760	COG0625	glutathione transferase activity
C2L64_RS43765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2L64_RS43765	COG1017	nitric oxide dioxygenase activity
C2L64_RS43785	COG3713	MltA-interacting MipA family protein
C2L64_RS43850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L64_RS43855	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2L64_RS43860	COG1595	DNA-templated transcription, initiation
C2L64_RS43875	COG2271	Major facilitator Superfamily
C2L64_RS43880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2L64_RS43895	COG0431	NADPH-dependent FMN reductase
C2L64_RS43900	COG0798	PFAM Bile acid sodium symporter
C2L64_RS43905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2L64_RS43925	COG1278	Cold shock
C2L64_RS43960	COG0583	DNA-binding transcription factor activity
C2L64_RS43965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2L64_RS43970	COG2271	Major facilitator Superfamily
C2L64_RS43975	COG0583	DNA-binding transcription factor activity
C2L64_RS44010	COG0235	Class ii aldolase
C2L64_RS44015	COG0477	Major facilitator Superfamily
C2L64_RS44020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS44030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2L64_RS44035	COG1620	l-lactate permease
C2L64_RS44045	COG2226	methyltransferase
C2L64_RS44060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS44070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2L64_RS44075	COG2010	Cytochrome c
C2L64_RS44080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2L64_RS44085	COG0765	amino acid transport
C2L64_RS44090	COG0765	amino acid transport
C2L64_RS44095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2L64_RS44110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS44115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS44125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS44130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS44155	COG1473	amidohydrolase
C2L64_RS44165	COG1522	sequence-specific DNA binding
C2L64_RS44170	COG0683	leucine binding
C2L64_RS44190	COG2205	protein histidine kinase activity
C2L64_RS44200	COG0745	RESPONSE REGULATOR receiver
C2L64_RS44215	COG1024	Enoyl-CoA hydratase
C2L64_RS44215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS44220	COG0583	DNA-binding transcription factor activity
C2L64_RS44225	COG1764	response to oxidative stress
C2L64_RS44235	COG0596	Alpha beta hydrolase
C2L64_RS44255	COG0025	NhaP-type Na H and K H
C2L64_RS44300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS44315	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2L64_RS44325	COG2204	response regulator
C2L64_RS44350	COG3504	Conjugal transfer protein
C2L64_RS44465	COG0629	single-stranded DNA binding
C2L64_RS44860	COG0210	DNA helicase
C2L64_RS44895	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2L64_RS44905	COG3360	Dodecin
C2L64_RS44915	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2L64_RS44940	COG0583	DNA-binding transcription factor activity
C2L64_RS44960	COG2204	response regulator
C2L64_RS45005	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS45050	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS45080	COG4251	negative regulation of phosphorylation
C2L64_RS45080	COG5001	Diguanylate cyclase
C2L64_RS45080	COG3706	GGDEF domain
C2L64_RS45080	COG2203	Gaf domain
C2L64_RS45105	COG0671	phosphoesterase, PA-phosphatase related
C2L64_RS45110	COG2814	Major facilitator Superfamily
C2L64_RS45125	COG2217	Heavy metal translocating P-type atpase
C2L64_RS45145	COG1704	LemA family
C2L64_RS45150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2L64_RS45165	COG1484	DNA-dependent DNA replication
C2L64_RS45170	COG2390	Transcriptional regulator
C2L64_RS45170	COG4584	PFAM Integrase catalytic
C2L64_RS45245	COG0484	heat shock protein binding
C2L64_RS45305	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS45380	COG4191	Histidine kinase
C2L64_RS45380	COG0784	Response regulator, receiver
C2L64_RS45470	COG1484	DNA-dependent DNA replication
C2L64_RS45480	COG4974	Belongs to the 'phage' integrase family
C2L64_RS45485	COG0582	viral genome integration into host DNA
C2L64_RS45490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L64_RS45505	COG3415	Transposase
C2L64_RS45515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2L64_RS45570	COG4977	sequence-specific DNA binding
C2L64_RS45570	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS45580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS45580	COG2010	Cytochrome c
C2L64_RS45585	COG2080	2 iron, 2 sulfur cluster binding
C2L64_RS45590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2L64_RS45590	COG2010	Cytochrome c
C2L64_RS45595	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS45600	COG2814	Major facilitator Superfamily
C2L64_RS45605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2L64_RS45615	COG0783	Belongs to the Dps family
C2L64_RS45670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2L64_RS45695	COG3415	Transposase
C2L64_RS45705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2L64_RS45725	COG0583	DNA-binding transcription factor activity
C2L64_RS45735	COG0679	Auxin Efflux Carrier
C2L64_RS45770	COG1252	NADH dehydrogenase
C2L64_RS45785	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2L64_RS45800	COG0840	transmembrane signaling receptor activity
C2L64_RS45820	COG0583	DNA-binding transcription factor activity
C2L64_RS45835	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS45835	COG4977	sequence-specific DNA binding
C2L64_RS45855	COG0784	Response regulator, receiver
C2L64_RS45855	COG2205	protein histidine kinase activity
C2L64_RS45855	COG2198	Histidine kinase
C2L64_RS45870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2L64_RS45875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2L64_RS45880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS45895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2L64_RS45920	COG4191	Histidine kinase
C2L64_RS45920	COG0784	Response regulator, receiver
C2L64_RS45930	COG1278	Cold shock
C2L64_RS46015	COG3609	addiction module antidote protein, CC2985 family
C2L64_RS46020	COG4974	Belongs to the 'phage' integrase family
C2L64_RS46075	COG3318	Belongs to the UPF0149 family
C2L64_RS46075	COG3012	SEC-C Motif Domain Protein
C2L64_RS46115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2L64_RS46120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2L64_RS46210	COG1074	ATP-dependent DNA helicase activity
C2L64_RS46270	COG0420	3'-5' exonuclease activity
C2L64_RS46285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2L64_RS46290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C2L64_RS46295	COG1074	ATP-dependent DNA helicase activity
C2L64_RS46300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2L64_RS46350	COG1160	GTP binding
C2L64_RS46360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2L64_RS46370	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2L64_RS46395	COG1686	Belongs to the peptidase S11 family
C2L64_RS46405	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L64_RS46410	COG1278	Cold shock
C2L64_RS46455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2L64_RS46470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2L64_RS46505	COG0642	Histidine kinase
C2L64_RS46550	COG2801	Transposase and inactivated derivatives
C2L64_RS46590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS46600	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS46725	COG2336	PFAM SpoVT AbrB
C2L64_RS46730	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2L64_RS46745	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS46780	COG1484	DNA-dependent DNA replication
C2L64_RS46790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L64_RS46795	COG0582	viral genome integration into host DNA
C2L64_RS46800	COG4974	Belongs to the 'phage' integrase family
C2L64_RS46815	COG3415	Transposase
C2L64_RS46870	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2L64_RS46885	COG0473	3-isopropylmalate dehydrogenase activity
C2L64_RS46895	COG2801	Transposase and inactivated derivatives
C2L64_RS46915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2L64_RS47010	COG0438	transferase activity, transferring glycosyl groups
C2L64_RS47075	COG4993	Dehydrogenase
C2L64_RS47080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS47115	COG1278	Cold shock
C2L64_RS47120	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L64_RS47205	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS47245	COG2197	response regulator
C2L64_RS47255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2L64_RS47305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS47310	COG2814	Major facilitator Superfamily
C2L64_RS47320	COG1024	Enoyl-CoA hydratase
C2L64_RS47325	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS47340	COG0517	IMP dehydrogenase activity
C2L64_RS47345	COG4974	Belongs to the 'phage' integrase family
C2L64_RS47350	COG0582	viral genome integration into host DNA
C2L64_RS47355	COG0582	viral genome integration into host DNA
C2L64_RS47360	COG4974	Belongs to the 'phage' integrase family
C2L64_RS47370	COG4974	Belongs to the 'phage' integrase family
C2L64_RS47375	COG0582	viral genome integration into host DNA
C2L64_RS47380	COG4974	Belongs to the 'phage' integrase family
C2L64_RS47430	COG2205	protein histidine kinase activity
C2L64_RS47430	COG5002	protein histidine kinase activity
C2L64_RS47430	COG0784	Response regulator, receiver
C2L64_RS47435	COG2197	response regulator
C2L64_RS47470	COG2826	transposase and inactivated derivatives, IS30 family
C2L64_RS47510	COG0745	RESPONSE REGULATOR receiver
C2L64_RS47550	COG3609	addiction module antidote protein, CC2985 family
C2L64_RS47565	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2L64_RS47575	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS47580	COG0183	Belongs to the thiolase family
C2L64_RS47660	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L64_RS47690	COG4191	Histidine kinase
C2L64_RS47710	COG0181	hydroxymethylbilane synthase activity
C2L64_RS47725	COG0778	Nitroreductase
C2L64_RS47740	COG2165	general secretion pathway protein
C2L64_RS47805	COG4566	intracellular signal transduction
C2L64_RS47820	COG4566	intracellular signal transduction
C2L64_RS47830	COG4566	intracellular signal transduction
C2L64_RS47860	COG2986	histidine ammonia-lyase
C2L64_RS47865	COG2423	ornithine cyclodeaminase activity
C2L64_RS47885	COG3220	belongs to the UPF0276 family
C2L64_RS47890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS47920	COG0625	glutathione transferase activity
C2L64_RS47930	COG2200	EAL domain
C2L64_RS47950	COG4191	Histidine kinase
C2L64_RS47950	COG2205	protein histidine kinase activity
C2L64_RS47950	COG0745	RESPONSE REGULATOR receiver
C2L64_RS47975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L64_RS47990	COG1333	cytochrome c biogenesis protein
C2L64_RS48010	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS48040	COG2814	Major facilitator Superfamily
C2L64_RS48055	COG3088	subunit of a heme lyase
C2L64_RS48065	COG1138	Cytochrome C-type biogenesis protein
C2L64_RS48070	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2L64_RS48090	COG4133	protoheme IX ABC transporter activity
C2L64_RS48120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L64_RS48180	COG4191	Histidine kinase
C2L64_RS48185	COG4566	intracellular signal transduction
C2L64_RS48210	COG2801	Transposase and inactivated derivatives
C2L64_RS48225	COG0583	DNA-binding transcription factor activity
C2L64_RS48250	COG4566	intracellular signal transduction
C2L64_RS48255	COG4191	Histidine kinase
C2L64_RS48270	COG0492	ferredoxin-NADP+ reductase activity
C2L64_RS48290	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS48305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2L64_RS48315	COG4977	sequence-specific DNA binding
C2L64_RS48315	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS48330	COG0625	glutathione transferase activity
C2L64_RS48350	COG2169	Transcriptional regulator
C2L64_RS48350	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS48385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS48390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2L64_RS48495	COG0408	coproporphyrinogen oxidase activity
C2L64_RS48510	COG0840	transmembrane signaling receptor activity
C2L64_RS48515	COG0251	oxidation-reduction process
C2L64_RS48520	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS48545	COG0583	DNA-binding transcription factor activity
C2L64_RS48550	COG4829	muconolactone delta-isomerase
C2L64_RS48555	COG3135	benzoate transporter
C2L64_RS48575	COG4566	intracellular signal transduction
C2L64_RS48790	COG1475	DNA binding
C2L64_RS48795	COG1192	Involved in chromosome partitioning
C2L64_RS48890	COG4372	Transposase
C2L64_RS48910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2L64_RS48915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2L64_RS48925	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS48930	COG4977	sequence-specific DNA binding
C2L64_RS48930	COG1917	Cupin 2, conserved barrel domain protein
C2L64_RS48945	COG0625	glutathione transferase activity
C2L64_RS48960	COG0410	ABC transporter
C2L64_RS48995	COG0431	NADPH-dependent FMN reductase
C2L64_RS49045	COG1113	amino acid transport
C2L64_RS49050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2L64_RS49070	COG0596	Alpha beta hydrolase
C2L64_RS49080	COG2186	Transcriptional regulator
C2L64_RS49085	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS49105	COG0625	glutathione transferase activity
C2L64_RS49135	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS49145	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS49150	COG2814	Major facilitator Superfamily
C2L64_RS49155	COG1879	ABC-type sugar transport system periplasmic component
C2L64_RS49160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2L64_RS49165	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS49170	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS49185	COG1902	pentaerythritol trinitrate reductase activity
C2L64_RS49190	COG1129	ABC transporter
C2L64_RS49195	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2L64_RS49200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49220	COG1053	succinate dehydrogenase
C2L64_RS49235	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS49260	COG2084	Dehydrogenase
C2L64_RS49305	COG0411	ABC transporter
C2L64_RS49325	COG0840	transmembrane signaling receptor activity
C2L64_RS49345	COG0583	DNA-binding transcription factor activity
C2L64_RS49390	COG2814	Major facilitator Superfamily
C2L64_RS49395	COG3038	cytochrome b561
C2L64_RS49405	COG2353	YceI-like domain
C2L64_RS49410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49415	COG0840	transmembrane signaling receptor activity
C2L64_RS49440	COG1846	Transcriptional regulator
C2L64_RS49445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2L64_RS49485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2L64_RS49490	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS49495	COG2814	Major facilitator Superfamily
C2L64_RS49505	COG1234	tRNA 3'-trailer cleavage
C2L64_RS49515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49550	COG0840	transmembrane signaling receptor activity
C2L64_RS49555	COG0840	transmembrane signaling receptor activity
C2L64_RS49590	COG2271	Major facilitator Superfamily
C2L64_RS49595	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS49635	COG1309	transcriptional regulator
C2L64_RS49640	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS49645	COG3842	ATPase activity
C2L64_RS49655	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2L64_RS49660	COG1177	transmembrane transport
C2L64_RS49665	COG0506	proline dehydrogenase activity
C2L64_RS49665	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2L64_RS49665	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2L64_RS49695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS49715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS49735	COG1113	amino acid transport
C2L64_RS49745	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS49750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2L64_RS49835	COG2207	Transcriptional regulator
C2L64_RS49835	COG1609	Transcriptional regulator
C2L64_RS49845	COG1335	isochorismatase
C2L64_RS49925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2L64_RS49965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2L64_RS49975	COG3609	addiction module antidote protein, CC2985 family
C2L64_RS50160	COG3685	Protein conserved in bacteria
C2L64_RS50200	COG4191	Histidine kinase
C2L64_RS50200	COG0784	Response regulator, receiver
C2L64_RS50240	COG1546	Belongs to the CinA family
C2L64_RS50240	COG1058	Belongs to the CinA family
C2L64_RS50245	COG0243	molybdopterin cofactor binding
C2L64_RS50250	COG1295	ribonuclease BN
C2L64_RS50265	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS50310	COG3546	catalase activity
C2L64_RS50320	COG3685	Protein conserved in bacteria
C2L64_RS50325	COG1914	H( )-stimulated, divalent metal cation uptake system
C2L64_RS50405	COG0604	alcohol dehydrogenase
C2L64_RS50410	COG0300	oxidoreductase activity
C2L64_RS50420	COG3540	Alkaline phosphatase
C2L64_RS50450	COG5001	Diguanylate cyclase
C2L64_RS50450	COG4251	negative regulation of phosphorylation
C2L64_RS50450	COG2203	Gaf domain
C2L64_RS50450	COG3706	GGDEF domain
C2L64_RS50515	COG0784	Response regulator, receiver
C2L64_RS50515	COG2198	Histidine kinase
C2L64_RS50515	COG5002	protein histidine kinase activity
C2L64_RS50520	COG2197	response regulator
C2L64_RS50580	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C2L64_RS50660	COG1012	belongs to the aldehyde dehydrogenase family
C2L64_RS50675	COG4974	Belongs to the 'phage' integrase family
C2L64_RS50790	COG1845	cytochrome c oxidase, subunit III
C2L64_RS50795	COG1845	cytochrome c oxidase, subunit III
C2L64_RS50800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2L64_RS50805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2L64_RS50840	COG1331	Highly conserved protein containing a thioredoxin domain
C2L64_RS50855	COG1690	Belongs to the RtcB family
C2L64_RS50865	COG1881	PFAM PEBP family protein
C2L64_RS50920	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS50970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2L64_RS51045	COG2146	nitrite reductase [NAD(P)H] activity
C2L64_RS51050	COG2151	metal-sulfur cluster biosynthetic enzyme
C2L64_RS51055	COG0822	iron-sulfur transferase activity
C2L64_RS51065	COG0719	Fe-S assembly protein
C2L64_RS51070	COG0396	ATPase activity
C2L64_RS51075	COG0719	Fe-S assembly protein
C2L64_RS51080	COG1959	2 iron, 2 sulfur cluster binding
C2L64_RS51140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2L64_RS51255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2L64_RS51270	COG1923	regulation of RNA biosynthetic process
C2L64_RS51290	COG1278	Cold shock
C2L64_RS51295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2L64_RS51315	COG0776	regulation of translation
C2L64_RS51345	COG0653	protein targeting
C2L64_RS51350	COG3318	Belongs to the UPF0149 family
C2L64_RS51350	COG3012	SEC-C Motif Domain Protein
C2L64_RS51385	COG2200	EAL domain
C2L64_RS51390	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS51410	COG1254	Belongs to the acylphosphatase family
C2L64_RS51435	COG0745	RESPONSE REGULATOR receiver
C2L64_RS51455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2L64_RS51475	COG4191	Histidine kinase
C2L64_RS51560	COG3345	alpha-galactosidase
C2L64_RS51575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2L64_RS51600	COG1024	Enoyl-CoA hydratase
C2L64_RS51605	COG4670	ketone body catabolic process
C2L64_RS51610	COG1309	transcriptional regulator
C2L64_RS51630	COG3547	Transposase (IS116 IS110 IS902 family)
C2L64_RS51640	COG3360	Dodecin
C2L64_RS51720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2L64_RS51775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2L64_RS51775	COG4651	solute:proton antiporter activity
C2L64_RS51880	COG0477	Major facilitator Superfamily
C2L64_RS51885	COG1024	Enoyl-CoA hydratase
C2L64_RS51895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2L64_RS51900	COG0583	DNA-binding transcription factor activity
C2L64_RS51965	COG5002	protein histidine kinase activity
C2L64_RS51985	COG0741	lytic transglycosylase activity
C2L64_RS51985	COG1196	nuclear chromosome segregation
C2L64_RS51985	COG0739	heme binding
C2L64_RS52045	COG1672	PFAM Archaeal ATPase
C2L64_RS52045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C2L64_RS52075	COG1024	Enoyl-CoA hydratase
C2L64_RS52080	COG1309	transcriptional regulator
C2L64_RS52095	COG3047	cAMP biosynthetic process
C2L64_RS52105	COG0318	PFAM AMP-dependent synthetase and ligase
C2L64_RS52130	COG1538	Outer membrane efflux protein
C2L64_RS52135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2L64_RS52200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2L64_RS52215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2L64_RS52225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2L64_RS52240	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS52245	COG0604	alcohol dehydrogenase
C2L64_RS52250	COG1028	Short-chain dehydrogenase reductase Sdr
C2L64_RS52270	COG0300	oxidoreductase activity
C2L64_RS52300	COG4948	Mandelate Racemase Muconate Lactonizing
C2L64_RS52330	COG0626	cystathionine gamma-synthase activity
C2L64_RS52360	COG3505	Type IV secretory pathway VirD4
C2L64_RS52450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2L64_RS52495	COG1192	Involved in chromosome partitioning
C2L64_RS52585	COG0183	Belongs to the thiolase family
C2L64_RS52605	COG1414	Transcriptional regulator
C2L64_RS52610	COG1024	Enoyl-CoA hydratase
C2L64_RS52685	COG3250	beta-galactosidase activity
C2L64_RS52705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2L64_RS52730	COG2916	Histone family protein nucleoid-structuring protein H-NS
C2L64_RS52775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2L64_RS52830	COG0358	DNA primase activity
C2L64_RS52850	COG0551	DNA topoisomerase type I activity
C2L64_RS52850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone